Staff Profile

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Career Summary

Biography

I am a post-doctoral researcher based at the HMRI. My work focuses on regulation of cell death and inflammation, in particular in the brain. I completed my PhD in cell biology/neuroscience at the University of Cambridge, UK, in 2008 and have subsequently held post-doctoral positions at the Beatson Institute for Cancer Research, Glasgow, UK and at the University of Cambridge. I joined Professor Phil Hansbro's group at the University of Newcastle in 2012, and am currently examining the role of mast cells in causing various types of inflammatory disease pathology.

Qualifications

  • PhD, University of Cambridge - UK, 19/07/2008

Research

Research keywords

  • Apoptosis
  • Cachexia
  • Efferocytosis
  • Mast Cell
  • Microglia
  • Muscle
  • Necrosis
  • Neurodegeneration
  • Neuroinflammation

Research expertise

Research expertise in:

Molecular analysis of cell death pathways including apoptosis, necrosis, necroptosis, phagoptosis, phagocytosis.

Primary culture of neurons and glial cells.

Mechanisms of neurodegeneration and neuroprotection.

Mechanisms of inflammatory neurodegeneration involving microglia.

Mast cells and their role in disease.

Study of muscle and fat wastage in chronic inflammatory diseases.

Fields of Research

CodeDescriptionPercentage
110203Respiratory Diseases50
060100Biochemistry And Cell Biology25
110900Neurosciences25

Teaching

Teaching keywords

  • Biochemistry
  • Cell Biology
  • Human Disease
  • Molecular Biology

Teaching expertise

Teaching expertise:

Extensive experience in leading small group tutorials covering a broad range of basic biochemical and genetic topics and their relation to disease.

Extensive experience assisting and leading laboratory based undergraduate practical classes and facilitating results analysis and discussion in large and small teaching groups.

Extensive experience in day-to-day and overall project supervision of laboratory based masters and PhD students.

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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2012Fricker M, Neher J, Zhao J-W, Thery C, Tolkovsky A, Brown G, 'MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation', The Journal of Neuroscience, 32 2657-2666 (2012) [C1]
2010Fricker M, O'Prey J, Tolkovsky A, Ryan K, 'Phosphorylation of Puma modulates its apoptotic function by regulating protein stability', Cell Death and Disease, 1 e59-e59 (2010) [C1]
2010Fricker M, Leveille F, Papadia S, Bell K, Soriano F, Martel M-A, et al., 'Suppression of the intrinsic apoptosis pathway by synaptic activity', The Journal of Neuroscience, 30 2623-2635 (2010) [C1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Chapter (1 outputs)

YearCitationAltmetricsLink
2011Fricker M, Tolkovsky A, 'Necrosis, Apoptosis, and Autophagy: Mechanisms of Neuronal and Glial Cell Death', Cell Culture Techniques, Neuromethods, Springer, London, UK 305-330 (2011) [B1]

Journal article (11 outputs)

YearCitationAltmetricsLink
2013Fricker M, Vilalta A, Tolkovsky AM, Brown GC, 'Caspase Inhibitors Protect Neurons by Enabling Selective Necroptosis of Inflamed Microglia', JOURNAL OF BIOLOGICAL CHEMISTRY, 288 9145-9152 (2013)
2013Neher JJ, Emmrich JV, Fricker M, Mander PK, Brown GC, Théry C, 'Phagocytosis executes delayed neuronal death after focal brain ischemia', Proceedings of the National Academy of Sciences of the United States of America, 110 (2013)
2012Fricker M, Neher J, Zhao J-W, Thery C, Tolkovsky A, Brown G, 'MFG-E8 Mediates Primary Phagocytosis of Viable Neurons during Neuroinflammation', The Journal of Neuroscience, 32 2657-2666 (2012) [C1]
2012Fricker M, Oliva-Martin MJ, Brown G, 'Primary phagocytosis of viable neurons by microglia activated with LPS or Abeta is dependent on calreticulin/LRP phagocytic signalling.', Journal of Neuroinflammation, 9 196-e196 (2012) [C1]
2010Fricker M, O'Prey J, Tolkovsky A, Ryan K, 'Phosphorylation of Puma modulates its apoptotic function by regulating protein stability', Cell Death and Disease, 1 e59-e59 (2010) [C1]
2010Fricker M, Leveille F, Papadia S, Bell K, Soriano F, Martel M-A, et al., 'Suppression of the intrinsic apoptosis pathway by synaptic activity', The Journal of Neuroscience, 30 2623-2635 (2010) [C1]
2010Fricker M, Papadia S, Hardingham G, Tolkovsky A, 'Implication of TAp73 in the p53-independent pathway of Puma induction and Puma-dependent apoptosis in primary cortical neurons', Journal of Neurochemistry, 114 772-783 (2010) [C1]
2009Wilkinson S, O'Prey J, Fricker M, Ryan K, 'Hypoxia-selective macroautophagy and cell survival signaled by autocrine PDGFR activity', Genes and Development, 23 1283-1288 (2009) [C1]
2005Fricker M, Lograsso P, Ellis S, Wilkie N, Hunt P, Pollack S, 'Substituting c-Jun N-terminal kinase-3 (JNK3) ATP-binding site amino acid residues with their p38 counterparts affects binding of JNK-and p38-selective inhibitors', Archives of Biochemistry and Biophysics, 438 195-205 (2005) [C1]
2005Fricker M, Wong HK, Wyttenbach A, Villunger A, Michalak E, Strasser A, Tolkovsky A, 'Mutually exclusive subsets of BH3-only proteins are activated by the p53 and c-Jun N-terminal kinase/c-Jun signaling pathways during cortical neuron apoptosis induced by arsenite', Molecular and Cellular Biology, 25 8732-8747 (2005) [C1]
2003Beher D, Fricker M, Nadin A, Clarke E, Wrigley J, Li Y-M, et al., 'In vitro characterization of the presenilin-dependent y-secretase complex using a novel affinity ligand', Biochemistry, 42 8133-8142 (2003) [C1]
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Grants and Funding

Summary

Number of grants3
Total funding$33,000

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2013 (1 grants)

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Mr Andrew Jarnicki, Doctor Michael Fricker
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020132013
GNo:G1201186

2012 (2 grants)

Elucidation of mechanisms of cachexia in COPD$10,000
Funding Body: University of Newcastle

Project Team
Doctor Michael Fricker
SchemeRole
Early Career Researcher GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00020122012
GNo:G1200889

Investigating the role of MIC-1 in causing cachexia associated with chronic obstructive pulmonary disease$3,000
Funding Body: University of Newcastle

Project Team
Doctor Michael Fricker
SchemeRole
New Staff GrantChief Investigator
Total AmountFunding StartFunding Finish
$3,00020122012
GNo:G1200869
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Research Supervision

Number of current supervisions0

No Supervisions.

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Dr Michael Fricker

Work Phone(02) 4042 0207
Email
PositionResearch Associate
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Office
2408 ,
Hunter Medical Research Institute
URL:www.newcastle.edu.au/profile/michael-fricker