Dr Simon Keely

Dr Simon Keely

Senior Lecturer

School of Biomedical Sciences and Pharmacy (Immunology and Microbiology)

Career Summary

Biography

Dr. Keely graduated with a Ph.D. from University College Dublin. He undertook postdoctoral research training at the Mucosal Inflammation Program in University of Colorado Denver before being promoted to junior faculty positions (Instructor and Senior Instructor) in the School of Medicine and receiving a prestigious fellowship from the Crohn's and Colitis Foundation of America. Dr. Keely is chief investigator of the Hunter Medical Research Institute (HMRI) Gastrointestinal Research Group. The group's current research examines molecular mechanisms of disease in the gastrointestinal tract. Dr. Keely is particularly interested in how the mucosal tissues function and repair with reduced oxygen availability during inflammation. Dr. Keely is also interested in the changes that occur with microbial interactions during inflammation and how these interactions influence the progression and resolution of mucosal diseases. The ultimate goal of this research is understanding how these factors may be pharmacologically manipulated for therapeutic benefit.

Research Expertise
The Gastrointestinal Research Group is focused on studying the cellular processes of digestive disease and infection. The group is particularly interested in mucosal inflammation and how tissues adapt to conditions of oxygen deficiency (hypoxia) in inflamed tissue. This is particularly relevant to chronic inflammatory diseases such as the inflammatory bowel diseases (IBD); Crohn's disease & ulcerative colitis. To achieve this, we study cellular mechanisms of inflammation and adaption to inflammation in vitro. We give our findings physiological context by applying them to in vivo models of IBD and then, through our collaborators at John Hunter Hospital, examine human context in patient samples. With this approach, we hope to identify strategies for new therapeutic approaches to treating IBD. Our current, ongoing research: 1) Investigates how wound healing is regulated in the intestine during the inflammation associated with Crohn's disease. 2) Examines the mechanisms leading to IBD-related disease that occurs outside of the gastrointestinal tract. 3) Explores how a new experimental drug, which promotes accelerated remission, regulates the immune system in models of IBD. 4) Examines how pain is regulated in the intestines in chronic IBD.

Teaching Expertise
My teaching covers topics of Immunology, Microbiology and Scientific Skills and Development across a range of degree courses and modules. For 2012 I teach into the following Biomedical Science courses: http://www.newcastle.edu.au/course/HUBS1404.html HUBS1404 Biomedical Science 2 http://www.newcastle.edu.au/course/HUBS1416.html HUBS1416 Advanced Human Bioscience http://www.newcastle.edu.au/course/HUBS2601.html HUBS2601 Human Infection and Immunity 1 http://www.newcastle.edu.au/course/HUBS3602.html HUBS3602 Human Infection and Immunity 2 http://www.newcastle.edu.au/course/HUBS3204.html HUBS3204 Advanced Professional Skills in Biomedical Science In addition I present courses into: http://www.newcastle.edu.au/course/MEDI1015.html MEDI1015 Medical Science 1 http://www.newcastle.edu.au/course/MEDI2014.html MEDI2014 Medical Science 2 http://www.newcastle.edu.au/course/MEDI3018.html MEDI3018 Medical Science 3

Administrative Expertise
Broad expertise and experience in administration and committee panels. Served on international conference and workshop review committees, school and faculty executives and focus group panels. Member of Institutional Biosafety Committee Course Co-ordinator for HUBS3204 NHMRC Grant Review Panel Member 2012

Collaborations
Professor Phil Hansbro, University of Newcastle Professor Alan Baird, University College Dublin, Ireland Professor Sean Colgan, University of Colorado Denver, Colorado, USA Professor Robert Callister, University of Newcastle Dr. Jay Horvat, University of Newcastle


Keywords

  • Cell Biology
  • Crohn's Disease
  • Epithelial Biology
  • HIF Biology
  • Hypoxia
  • Immunology
  • Infection
  • Inflammatory Bowel Disease
  • Microbiology
  • Molecular Biology
  • Mucosal Inflammation
  • Ulcerative Colitis
  • clinical science
  • host-pathogen interactions
  • microbiome

Languages

  • Irish (Fluent)

Fields of Research

Code Description Percentage
060199 Biochemistry and Cell Biology not elsewhere classified 35
110307 Gastroenterology and Hepatology 35
110799 Immunology not elsewhere classified 30

Professional Experience

UON Appointment

Title Organisation / Department
Senior Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
1/01/2012 -  Membership - NHMRC GRP NHMRC GRP
Australia
1/01/2011 -  Membership - Australian Society for Immunology Australian Society for Immunology
Australia
1/01/2011 -  Membership - Gastroenterological Society of Australia Gastroenterological Society of Australia
1/01/2010 - 1/02/2011 Senior Instructor University of Colorado, Denver
Mucosal Inflammation Program
United States
1/12/2009 - 1/02/2011 Senior Instructor

Crohn's & Colitis Foundation of America Research Fellow

University of Colorado, Denver
United States
1/12/2008 - 1/12/2009 Instructor University of Colorado, Denver
United States
1/11/2008 - 1/01/2010 Instructor

Junior Faculty

University of Colorado, Denver
Mucosal Inflammation Program
United States
1/07/2006 - 1/11/2008 Postdoctoral Research Fellow University of Colorado, Denver
Mucosal Inflammation Program
United States
1/10/2005 - 1/07/2006 Postdoctoral Research Fellow University College Dublin
School of Veterinary Medicine
Ireland

Professional appointment

Dates Title Organisation / Department
8/10/2015 -  Gastrointestinal Research Group Leader Hunter Medical Research Institute (HMRI)
Viruses, Infection/Immunity, Vaccines and Asthma Program
Australia
1/01/2014 -  Scientific Advisory Board Aetheria Therapeutics
United States
1/01/2013 - 1/12/2014 Scientific Consultant Janssen Cilag Pty Ltd

Awards

Prize

Year Award
2014 John Forte GI/Liver Plenary Award for Distinguished Abstract
American Physiological Society
2011 Outstanding Paper Award - GI Response to Injury
American Gastroenterological Association
2009 Outstanding Paper Award, Advances in IBD
Crohn's and Colitis Foundation of America

Research Award

Year Award
2009 Research Fellowship
Crohn's and Colitis Foundation of America

Thesis Examinations

Year Level Discipline Thesis
2015 PHD Health Immunology and IBD
2015 PHD Health Immunology and IBD
2015 PHD Health Immunology and IBD

Grant Reviews

Year Grant Amount
2013 Project Grant GRP
Aust Competitive - Commonwealth - 1CS, Aust Competitive - Commonwealth - 1CS
$0
2012 Project Grant GRP
Aust Competitive - Commonwealth - 1CS, Aust Competitive - Commonwealth - 1CS
$0
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (35 outputs)

Year Citation Altmetrics Link
2016 Farrell KE, Rank MM, Keely S, Brichta AM, Graham BA, Callister RJ, 'In vivo characterization of colorectal and cutaneous inputs to lumbosacral dorsal horn neurons in the mouse spinal cord', Neuroscience, 316 13-25 (2016) [C1]

© 2015 IBRO.Chronic abdominal pain is a common symptom of inflammatory bowel disease and often persists in the absence of gut inflammation. Although the mechanisms responsible fo... [more]

© 2015 IBRO.Chronic abdominal pain is a common symptom of inflammatory bowel disease and often persists in the absence of gut inflammation. Although the mechanisms responsible for ongoing pain are unknown, clinical and preclinical evidence suggests lumbosacral spinal cord dorsal horn neurons contribute to these symptoms. At present, we know little about the intrinsic and synaptic properties of this population of neurons in either normal or inflammed conditions. Therefore, we developed an in vivo preparation to make patch-clamp recordings from superficial dorsal horn (SDH) neurons receiving colonic inputs in naïve male mice. Recordings were made in the lumbosacral spinal cord (L6-S1) under isoflurane anesthesia. Noxious colorectal distension (CRD) was used to determine whether SDH neurons received inputs from mechanical stimulation/distension of the colon. Responses to hind paw/tail cutaneous stimulation and intrinsic and synaptic properties were also assessed, as well as action potential discharge properties. Approximately 11% of lumbosacral SDH neurons in the cohort of neurons sampled responded to CRD and a majority of these responses were subthreshold. Most CRD-responsive neurons (80%) also responded to cutaneous stimuli, compared with <50% of CRD-non-responsive neurons. Furthermore, CRD-responsive neurons had more hyperpolarized resting membrane potentials, larger rheobase currents, and reduced levels of excitatory drive, compared to CRD-non-responsive neurons. Our results demonstrate that CRD-responsive neurons can be distinguished from CRD-non-responsive neurons by several differences in their membrane properties and excitatory synaptic inputs. We also demonstrate that SDH neurons with colonic inputs show predominately subthreshold responses to CRD and exhibit a high degree of viscerosomatic convergence.

DOI 10.1016/j.neuroscience.2015.12.023
Co-authors Michelle Rank, Alan Brichta, Robert Callister, Brett Graham
2016 Cuív P, Begun J, Keely S, Lewindon PJ, Morrison M, 'Towards an integrated understanding of the therapeutic utility of exclusive enteral nutrition in the treatment of Crohn's disease', Food and Function, 7 1741-1751 (2016) [C1]

© 2016 The Royal Society of Chemistry.Crohn's disease (CD) is a chronic disease characterized by episodic and disabling inflammation of the gastrointestinal tract in genetically ... [more]

© 2016 The Royal Society of Chemistry.Crohn's disease (CD) is a chronic disease characterized by episodic and disabling inflammation of the gastrointestinal tract in genetically susceptible individuals. The incidence and prevalence of CD is rising rapidly across the world emphasising that disease risk is also influenced by environmental and lifestyle factors, as well as the microbial community resident in the gut. Childhood-onset CD is associated with an aggressive disease course that can adversely impact patient growth and development. There is no cure for CD however new onset and recurrent cases of paediatric CD are often responsive to exclusive enteral nutrition (EEN) treatment. EEN treatment involves the exclusive consumption of an elemental or polymeric formula for several weeks and it is well established as a primary intervention strategy. EEN treatments typically achieve remission rates of over 80% and importantly they are associated with a high rate of mucosal healing, far superior to steroids, which is prognostic of improved long-term health outcomes. Furthermore, they are safe, have few side effects, and improve nutritional status and linear growth. Surprisingly, despite the utility of EEN our understanding of the host-microbe-diet interactions that underpin clinical remission and mucosal healing are limited. Here, we review the current state of knowledge and propose that the induction of autophagy, in addition to modulation of the microbiota and coordinated effects on inflammation and epithelial cell biology, may be critical for the therapeutic effects associated with EEN. A better understanding of EEN treatment will provide new opportunities to restore gut homeostasis and prolong periods of remission, as well as provide new insights into the factors that trigger and perhaps prevent CD.

DOI 10.1039/c5fo01196e
2016 Mateer SW, Cardona J, Marks E, Goggin BJ, Hua S, Keely S, 'Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease.', J Vis Exp, e53250 (2016)
DOI 10.3791/53250
Co-authors Susan Hua
2015 Mateer SW, Maltby S, Marks E, Foster PS, Horvat JC, Hansbro PM, Keely S, 'Potential mechanisms regulating pulmonary pathology in inflammatory bowel disease.', J Leukoc Biol, 98 727-737 (2015) [C1]
DOI 10.1189/jlb.3RU1114-563R
Co-authors Paul Foster, Philip Hansbro, Steven Maltby, Jay Horvat
2015 Hua S, Marks E, Schneider JJ, Keely S, 'Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: selective targeting to diseased versus healthy tissue.', Nanomedicine, 11 1117-1132 (2015) [C1]
DOI 10.1016/j.nano.2015.02.018
Citations Scopus - 13
Co-authors Jennifer Schneider, Susan Hua
2015 Kim RY, Horvat JC, Pinkerton JW, Starkey MR, Essilfie AT, Mayall JR, et al., 'MicroRNA-21 drives severe, steroid-insensitive experimental asthma by amplifying phosphoinositide 3-kinase-mediated suppression of histone deacetylase 2', Journal of Allergy and Clinical Immunology, (2015)

© 2016 American Academy of Allergy, Asthma & Immunology.Background: Severe steroid-insensitive asthma is a substantial clinical problem. Effective treatments are urgently require... [more]

© 2016 American Academy of Allergy, Asthma & Immunology.Background: Severe steroid-insensitive asthma is a substantial clinical problem. Effective treatments are urgently required, however, their development is hampered by a lack of understanding of the mechanisms of disease pathogenesis. Steroid-insensitive asthma is associated with respiratory tract infections and noneosinophilic endotypes, including neutrophilic forms of disease. However, steroid-insensitive patients with eosinophil-enriched inflammation have also been described. The mechanisms that underpin infection-induced, severe steroid-insensitive asthma can be elucidated by using mouse models of disease. Objective: We sought to develop representative mouse models of severe, steroid-insensitive asthma and to use them to identify pathogenic mechanisms and investigate new treatment approaches. Methods: Novel mouse models of . Chlamydia, . Haemophilus influenzae, influenza, and respiratory syncytial virus respiratory tract infections and ovalbumin-induced, severe, steroid-insensitive allergic airway disease (SSIAAD) in BALB/c mice were developed and interrogated. Results: Infection induced increases in the levels of microRNA (miRNA)-21 (miR-21) expression in the lung during SSIAAD, whereas expression of the miR-21 target phosphatase and tensin homolog was reduced. This was associated with an increase in levels of phosphorylated Akt, an indicator of phosphoinositide 3-kinase (PI3K) activity, and decreased nuclear histone deacetylase (HDAC)2 levels. Treatment with an miR-21-specific antagomir (Ant-21) increased phosphatase and tensin homolog levels. Treatment with Ant-21, or the pan-PI3K inhibitor LY294002, reduced PI3K activity and restored HDAC2 levels. This led to suppression of airway hyperresponsiveness and restored steroid sensitivity to allergic airway disease. These observations were replicated with SSIAAD associated with 4 different pathogens. Conclusion: We identify a previously unrecognized role for an miR-21/PI3K/HDAC2 axis in SSIAAD. Our data highlight miR-21 as a novel therapeutic target for the treatment of this form of asthma.

DOI 10.1016/j.jaci.2016.04.038
Co-authors Philip Hansbro, Malcolm Starkey, Paul Foster, Joerg Mattes, Jay Horvat
2015 Keely S, Walker MM, Marks E, Talley NJ, 'Immune dysregulation in the functional gastrointestinal disorders', European Journal of Clinical Investigation, 45 1350-1359 (2015) [C1]
DOI 10.1111/eci.12548
Citations Scopus - 1Web of Science - 2
Co-authors Nicholas Talley, Marjorie Walker
2015 Keely S, Veysey M, Walker MM, Talley NJ, 'Letter: oxidative stress, cause or consequence of constipation-associated colorectal cancer?', Aliment Pharmacol Ther, 42 941-942 (2015) [C3]
DOI 10.1111/apt.13349
Co-authors Marjorie Walker, Martin Veysey, Nicholas Talley
2015 Marks E, Goggins BJ, Cardona J, Cole S, Minahan K, Mateer S, et al., 'Oral Delivery of Prolyl Hydroxylase Inhibitor: AKB-4924 Promotes Localized Mucosal Healing in a Mouse Model of Colitis.', Inflammatory bowel diseases, 21 267-275 (2015) [C1]
DOI 10.1097/mib.0000000000000277
Citations Scopus - 4Web of Science - 2
Co-authors Marjorie Walker
2015 Keely S, Foster PS, 'Stop Press: Eosinophils Drafted to Join the Th17 Team', IMMUNITY, 43 7-9 (2015) [C3]
DOI 10.1016/j.immuni.2015.07.010
Citations Scopus - 1
Co-authors Paul Foster
2014 Keely S, Hansbro PM, 'Lung-Gut Cross Talk A Potential Mechanism for Intestinal Dysfunction in Patients With COPD', CHEST, 145 199-200 (2014) [C3]
DOI 10.1378/chest.13-2077
Citations Scopus - 7Web of Science - 4
Co-authors Philip Hansbro
2014 Ward JBJ, Keely SJ, Keely SJ, 'Oxygen in the regulation of intestinal epithelial transport', Journal of Physiology, 592 2473-2489 (2014) [C1]

The transport of fluid, nutrients and electrolytes to and from the intestinal lumen is a primary function of epithelial cells. Normally, the intestine absorbs approximately 9 l of... [more]

The transport of fluid, nutrients and electrolytes to and from the intestinal lumen is a primary function of epithelial cells. Normally, the intestine absorbs approximately 9 l of fluid and 1 kg of nutrients daily, driven by epithelial transport processes that consume large amounts of cellular energy and O2. The epithelium exists at the interface of the richly vascularised mucosa, and the anoxic luminal environment and this steep O2 gradient play a key role in determining the expression pattern of proteins involved in fluid, nutrient and electrolyte transport. However, the dynamic nature of the splanchnic circulation necessitates that the epithelium can evoke co-ordinated responses to fluctuations in O2 availability, which occur either as a part of the normal digestive process or as a consequence of several pathophysiological conditions. While it is known that hypoxia-responsive signals, such as reactive oxygen species, AMP-activated kinase, hypoxia-inducible factors, and prolyl hydroxylases are all important in regulating epithelial responses to altered O2 supply, our understanding of the molecular mechanisms involved is still limited. Here, we aim to review the current literature regarding the role that O2 plays in regulating intestinal transport processes and to highlight areas of research that still need to be addressed. © 2014 The Physiological Society.

DOI 10.1113/jphysiol.2013.270249
Citations Scopus - 3
2014 Farrell KE, Keely S, Graham BA, Callister R, Callister RJ, 'A Systematic Review of the Evidence for Central Nervous System Plasticity in Animal Models of Inflammatory-mediated Gastrointestinal Pain', INFLAMMATORY BOWEL DISEASES, 20 176-195 (2014) [C1]
DOI 10.1097/01.MIB.0000437499.52922.b1
Citations Scopus - 6Web of Science - 5
Co-authors Brett Graham, Robin Callister, Robert Callister
2014 Farrell KE, Callister RJ, Keely S, 'Understanding and targeting centrally mediated visceral pain in inflammatory bowel disease', Frontiers in Pharmacology, 5 1-4 (2014) [C3]
DOI 10.3389/fphar.2014.00027
Citations Scopus - 1
Co-authors Robert Callister
2014 Keely S, Campbell EL, Baird AW, Hansbro PM, Shalwitz RA, Kotsakis A, et al., 'Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis', Mucosal Immunology, 7 114-123 (2014) [C1]

Pharmacological stabilization of hypoxia-inducible factor (HIF) through prolyl hydroxylase (PHD) inhibition limits mucosal damage associated with models of murine colitis. However... [more]

Pharmacological stabilization of hypoxia-inducible factor (HIF) through prolyl hydroxylase (PHD) inhibition limits mucosal damage associated with models of murine colitis. However, little is known about how PHD inhibitors (PHDi) influence systemic immune function during mucosal inflammation or the relative importance of immunological changes to mucosal protection. We hypothesized that PHDi enhances systemic innate immune responses to colitis-associated bacteremia. Mice with colitis induced by trinitrobenzene sulfonic acid were treated with AKB-4924, a new HIF-1 isoform-predominant PHDi, and clinical, immunological, and biochemical endpoints were assessed. Administration of AKB-4924 led to significantly reduced weight loss and disease activity compared with vehicle controls. Treated groups were pyrexic but did not become subsequently hypothermic. PHDi treatment augmented epithelial barrier function and led to an approximately 50-fold reduction in serum endotoxin during colitis. AKB-4924 also decreased cytokines involved in pyrogenesis and hypothermia, significantly reducing serum levels of interleukin (IL)-1ß, IL-6, and tumor necrosis factor (TNF)-a while increasing IL-10. Treatment offered no protection against colitis in epithelial-specific HIF-1a-deficient mice, strongly implicating epithelial HIF-1a as the tissue target for AKB-4924-mediated protection. Taken together, these results indicate that inhibition of prolyl hydroxylase with AKB-4924 enhances innate immunity and identifies that the epithelium is a central site of inflammatory protection afforded by PHDi in murine colitis. © 2014 Society for Mucosal Immunology.

DOI 10.1038/mi.2013.29
Citations Scopus - 25Web of Science - 21
Co-authors Philip Hansbro
2014 Goggins B, Minahan K, Kostakis A, Shalwitz R, Horvat J, Keely S, 'Stabilisation of epithelial hypoxia-inducible factor reverses colitis through accelerated restitution', FASEB JOURNAL, 28 (2014)
Co-authors Jay Horvat
2013 Goggins BJ, Chaney C, Radford-Smith GL, Horvat JC, Keely S, 'Hypoxia and Integrin-Mediated Epithelial Restitution during Mucosal Inflammation.', Front Immunol, 4 272 (2013) [C1]
DOI 10.3389/fimmu.2013.00272
Citations Scopus - 14Web of Science - 12
Co-authors Jay Horvat
2013 Hansbro P, Beckett E, Stevens R, Jarnicki A, Wark P, Foster P, 'A short-term model of COPD identifies a role for mast cell tryptase', EUROPEAN RESPIRATORY JOURNAL, 42 (2013)
Co-authors Philip Hansbro, Paul Foster, Peter Wark, Jay Horvat
2013 Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, et al., 'A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis', The Journal of Allergy and Clinical Immunology, 131 752-762 (2013) [C1]
Citations Scopus - 50Web of Science - 50
Co-authors Philip Hansbro, Nicole Hansbro, Paul Foster, Jay Horvat, Peter Wark, Ming Yang
2012 Keely S, Kelly C, Weissmueller T, Burgess A, Wagner B, Robertson CE, et al., 'Activated fluid transport regulates bacterial-epithelial interactions and significantly shifts the murine colonic microbiome', Gut Microbes, 3 250-260 (2012) [C1]
DOI 10.4161/gmic.20529
Citations Scopus - 18
2012 Keely S, Talley NJ, Hansbro PM, 'Pulmonary-intestinal cross-talk in mucosal inflammatory disease', Mucosal Immunology, 5 7-18 (2012) [C1]
Citations Scopus - 49Web of Science - 42
Co-authors Nicholas Talley, Philip Hansbro
2011 Macmanus C, Campbell E, Keely S, Adrienne B, Kominsky D, Colgan S, 'Anti-inflammatory actions of adrenomedullin through fine tuning of HIF stabilization', The FASEB Journal, 25 1856-1864 (2011) [C1]
DOI 10.1096/fj.10-170316
Citations Scopus - 24Web of Science - 23
2011 Keely S, Feighery L, Campion DP, O'Brien L, Brayden DJ, Baird AW, 'Chloride-led disruption of the intestinal mucous layer impedes salmonella invasion: Evidence for an 'enteric tear' mechanism', Cellular Physiology and Biochemistry, 28 743-752 (2011) [C1]
Citations Scopus - 6Web of Science - 5
2011 Kominsky D, Keely S, Macmanus C, Glover L, Scully M, Collins C, et al., 'An Endogenously Anti-Inflammatory Role for Methylation in Mucosal Inflammation Identified through Metabolite Profiling.', Journal of Immunology, 186 6505-6514 (2011) [C1]
DOI 10.4049/jimmunol.1002805
Citations Scopus - 25Web of Science - 21
2010 Campbell E, Macmanus C, Kominsky D, Keely S, Glover L, Scully M, et al., 'Resolvin E1-induced Intestinal Alkaline Phosphatase Promotes Resolution of Inflammation through LPS detoxification.', Proceedings of the National Academy of Sciences of USA, 107 4298-4303 (2010) [C1]
DOI 10.1073/pnas.0914730107
Citations Scopus - 62Web of Science - 53
2010 Keely S, Glover L, Weissmueller T, Macmanus C, Fillon S, Fennimore B, Colgan S, 'Hypoxia-inducible factor-dependent regulation of platelet-activating factor receptor as a route for gram-positive bacterial translocation across epithelia', Molecular Biology of the Cell, 21 538-546 (2010) [C1]
DOI 10.1091/mbc.E09-07-0573
Citations Scopus - 26Web of Science - 24
2009 Keely S, Ryan S, Haddleton D, Limer A, Mantovani G, Murphy E, Brayden D, 'Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers.', Journal of Controlled Release, 135 35-43 (2009) [C1]
DOI 10.1016/j.jconrel.2008.12.001
Citations Scopus - 21Web of Science - 23
2009 Keely S, Glover L, Macmanus C, Campbell E, Scully M, Furuta G, Colgan S, 'Selective induction of integrin beta1 by hypoxia-inducible factor: implications for wound healing.', The FASEB Journal, 23 1338-1346 (2009) [C1]
DOI 10.1096/fj.08-125344
Citations Scopus - 36
2008 Robinson A, Keely S, Karhausen J, Gerich M, Furuta G, Colgan S, 'Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition.', Gastroenterology, 134 346-348 (2008) [C1]
DOI 10.1053/j.gastro.2007.09.033
Citations Scopus - 178Web of Science - 170
2008 Feighery L, Smyth A, Keely S, Baird A, O'Connor W, Callanan J, Brayden D, 'Increased intestinal permeability in rats subjected to traumatic frontal lobe percussion brain injury.', Journal of Trauma: Injury Infection and Critical Care, 64 131-137 (2008) [C1]
DOI 10.1097/TA.0b013e3181568d9f
Citations Scopus - 17Web of Science - 17
2008 Boland T, Hayes L, Sweeney T, Callanan J, Baird A, Keely S, Crosby T, 'The effects of cobalt and iodine supplementation of the pregnant ewe diet on immunoglobulin G, vitamin E, T-3 and T-4 levels in the progeny.', Animal: the international journal of animal biosciences, 2 197-206 (2008) [C1]
DOI 10.1017/S175173110700105X
Citations Scopus - 11Web of Science - 11
2008 Fanning R, Campion D, Collins C, Keely S, Briggs L, O'Connor J, Carey M, 'A comparison of the inhibitory effects of bupivacaine and levobupivacaine on isolated human pregnant myometrium contractility.', Anesthesia and Analgesia, 107 1303-1307 (2008) [C1]
DOI 10.1213/ane.0b013e3181804245
Citations Scopus - 6Web of Science - 4
2008 Keely S, Rawlinson L-AB, Haddleton DM, Brayden DJ, 'A tertiary amino-containing polymethacrylate polymer protects mucus-covered intestinal epithelial monolayers against pathogenic challenge', Pharmaceutical Research, 25 1193-1201 (2008) [C1]
DOI 10.1007/s11095-007-9501-3
Citations Scopus - 11Web of Science - 10
2006 Limer A, Attvinder R, San Miguel V, Peinado C, Keely S, Fitzpatrick E, et al., 'Fluorescently tagged star polymers by living radical polymerisation for mucoadhesion and bioadhesion.', Reactive and Functional Polymers, 66 51-64 (2006) [C1]
DOI 10.1016/j.reactfunctpolym.2005.07.024
2005 Keely S, Atvinder R, Wilson C, Carmichael A, Carrington S, Corfield A, et al., 'In vitro and ex vivo intestinal tissue models to measure mucoadhesion of poly (methacrylate) and N-trimethylated chitosan polymers.', Pharmaceutical Research, 22 38-49 (2005) [C1]
DOI 10.1007/s11095-004-9007-1
Show 32 more journal articles

Conference (23 outputs)

Year Citation Altmetrics Link
2016 Horvat J, Kim R, Pinkerton J, Rae B, Starkey M, Essilfie A, et al., 'IDENTIFICATION OF NOVEL THERAPEUTIC TARGETS FOR STEROID-INSENSITIVE ASTHMA USING MODELS THAT REPRESENT DIFFERENT CLINICAL SUBTYPES OF DISEASE', RESPIROLOGY (2016)
Co-authors Joerg Mattes, Philip Hansbro, Jay Horvat
2016 Gellatly S, Dennis P, Jarnicki A, Lachner N, Wood D, Fricker M, et al., 'HEALTHY GUT MICROBIOTA AMELIORATES EXPERIMENTAL CHRONIC OBSTRUCTIVE PULMONARY DISEASE', RESPIROLOGY (2016)
Co-authors Philip Hansbro, Michael Fricker
2015 Kim R, Horvat J, Pinkerton J, Starkey M, Essilfie A, Mayall J, et al., 'INFECTION-INDUCED MICRORNA-21 DRIVES SEVERE, STEROID-INSENSITIVE EXPERIMENTAL ASTHMA BY AMPLIFYING PI3K-MEDIATED SUPPRESSION OF HDAC2', RESPIROLOGY (2015) [E3]
Co-authors Joerg Mattes, Philip Hansbro, Paul Foster, Malcolm Starkey, Jay Horvat
2015 Farrell K, Rank M, Keely S, Graham B, Callister R, 'In vivo electrophysiological characterisation of mouse lumbosacral dorsal horn neurons receiving visceral inputs', JOURNAL OF NEUROCHEMISTRY (2015) [E3]
Co-authors Michelle Rank, Robert Callister, Brett Graham
2015 Mateer S, Marks E, Maltby S, Goggins B, Horvat J, Hansbro P, Keely S, 'Pulmonary retention of PMN attracts primed intestinal lymphocytes in a mouse model of inflammatory bowel disease', FASEB JOURNAL (2015) [E3]
Co-authors Steven Maltby, Philip Hansbro, Jay Horvat
2015 Naudin C, Weidenhofer J, Roselli S, Keely S, 'Induction of Mindin is Associated with Pathological Changes in the Kidney of Cd151(-/-) Mice', FASEB JOURNAL (2015) [E3]
Co-authors Judith Weidenhofer
2014 Goggins B, Minahan K, Marks E, Mateer S, Cardona J, Knight D, et al., 'Hypoxia inducible factor (HIF)-1 accelerates epithelial wound healing through integrin regulation', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Darryl Knight, Jay Horvat
2014 Cardona J, Marks E, Goggins B, Mateer S, Minahan K, Horvat J, Keely S, 'The role of antibiotics in the development of food allergy', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Jay Horvat
2014 Marks E, Nolan G, Mateer S, Minahan K, Goggins B, Cardona J, Keely S, 'Hypoxia inducible factor 1 alpha (HIF-1 alpha) regulates anti-inflammatory lymphoid responses during colitis', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
2014 Mateer S, Maltby S, Marks E, Goggins B, Horvat J, Hansbro P, Keely S, 'Immune cell mis-homing drives secondary organ inflammation in inflammatory bowel disease; a focus on the respiratory system', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Steven Maltby, Jay Horvat, Philip Hansbro
2014 Farrell KE, Graham BA, Keely S, Callister RJ, 'Understanding the mechanisms underlying chronic pain in IBD: A new method for studying visceral inputs from the gastrointestinal tract', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Robert Callister, Brett Graham
2014 Fathi F, Hsu A, Parsons K, Keely S, Wood L, Wark P, 'OXIDATIVE STRESS IMPAIRS MITOCHONDRIAL FUNCTION AND LEADS TO DEFICIENT ANTIVIRAL RESPONSES IN PRIMARY BRONCHIAL EPITHELIAL CELLS', RESPIROLOGY (2014) [E3]
DOI 10.1111/resp.12263_3
Co-authors Alan Hsu, Lisa Wood, Peter Wark
2013 Hansbro P, Beckett E, Stevens R, Jarnicki A, Kim R, Hanish I, et al., 'A short-term model of COPD identifies a role for mast cell tryptase', JOURNAL OF IMMUNOLOGY (2013) [E3]
Co-authors Philip Hansbro, Nicole Hansbro, Paul Foster, Jay Horvat, Peter Wark, Ming Yang
2012 Farrell KE, Keely S, Graham BA, Minahan KL, Madden JF, Callister RJ, 'Spinal cord signalling in a mouse model of inflammatory bowel disease', Journal of Gastroenterology and Hepatology (2012) [E3]
Co-authors Brett Graham, Robert Callister
2012 Nolan GM, Minahan KL, Farrell KE, Chaney C, Mateer S, Talley NJ, Keely S, 'Hypoxia-inducible factor-1 a promotes mucosal protection in colitis via the IL-12 signalling pathway', Journal of Gastroenterology and Hepatology (2012) [E3]
Co-authors Nicholas Talley
2012 Mateer S, Hansbro PM, Nolan GM, Chaney C, Minahan KL, Keely S, 'Development of pulmonary inflammation and altered lung function in a mouse model of colitis', Journal of Gastroenterology and Hepatology (2012) [E3]
Co-authors Philip Hansbro
2012 Keely S, Baird AW, Colgan S, 'Epithelial HIF-1 a is critical to the protective action of prolyl hydroxylase inhibition in a murine model of inflammatory bowel disease', Journal of Gastroenterology and Hepatology (2012) [E3]
2012 Chaney C, Minahan KL, Mateer S, Nolan GM, Talley NJ, Keely S, 'Hypoxic regulation of ß1 integrin during mucosal wound healing', Journal of Gastroenterology and Hepatology (2012) [E3]
Co-authors Nicholas Talley
2012 Keely S, Baird A, Kominsky D, McNamee EN, Hansbro PM, Shalwitz RA, Colgan SP, 'Immune modulation by prolyl hydroxylase inhibition contributes to the prevention of endotoxemia in a murine model of inflammatory bowel disease', FASEB Journal (2012) [E3]
Co-authors Philip Hansbro
2011 Kominsky D, Keely S, Macmanus C, Glover L, Scully M, Collins C, et al., 'Cellular methylation plays an anti-inflammatory role in Mucosal Inflammation', Inflammatory Bowel Diseases (2011) [E3]
2011 Keely S, Baird A, Kominsky D, Campbell E, Burgess A, Colgan S, 'HIF prolyl hydroxylase inhibition reverses disease symptoms in established TNBS colitis', Inflammatory Bowel Diseases (2011) [E3]
2011 Campbell E, Macmanus C, Kominsky D, Keely S, Glover L, Bowers B, et al., 'Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification', Inflammatory Bowel Diseases (2011) [E3]
2011 Kominsky D, Keely S, Campbell E, Christopher M, Scully M, Collins C, et al., 'A central role of methylation in mucosal inflammation', Inflammatory Bowel Diseases (2011) [E3]
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Grants and Funding

Summary

Number of grants 22
Total funding $2,071,219

Click on a grant title below to expand the full details for that specific grant.


20161 grants / $20,000

Emlyn and Jennie Thomas Postgraduate Medical Research Scholarship$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Miss Bridie Goggins, Doctor Simon Keely, Professor Darryl Knight, Doctor Jay Horvat
Scheme Postgraduate Research Scholarship
Role Lead
Funding Start 2016
Funding Finish 2017
GNo G1600721
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20154 grants / $514,201

Chlamydia and reproductive health $475,526

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team

Kenneth Beagley

Scheme Project Grant
Role Investigator
Funding Start 2015
Funding Finish 2018
GNo
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON N

A novel model of colorectal cancer for studying personalised tumour biology, metastasis and the role of the microbiome$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Simon Keely
Scheme Project Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1501436
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Too Much of a Good Thing: Application for a triple-gas incubator to allow cell culture under normal conditions$16,675

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Craig Gedye, Professor Rodney Scott, Doctor Nikola Bowden, Doctor Simon Keely, Doctor Kathryn Skelding
Scheme Research Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1500730
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Experimental Biology 2015, Boston USA, 26 March-1 April 2015$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Simon Keely
Scheme Travel Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1500204
Type Of Funding Internal
Category INTE
UON Y

20146 grants / $628,792

Spinal processing of sensory signals from the gut$536,226

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Robert Callister, Doctor Simon Keely, Associate Professor Brett Graham, Professor Alan Brichta, Dr David Hughes
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2016
GNo G1300361
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Activating natural protective and healing responses in chronic inflammatory bowel disease$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Simon Keely, Doctor Ellen Marks, Associate Professor Martin Veysey
Scheme Research Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1401453
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Miltenyi Biotec GentleMACS Octo Dissociator with Heaters $23,566

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Darryl Knight, Professor Dirk Van Helden, Professor Joerg Mattes, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Associate Professor Liz Milward, Dr NATHAN Bartlett, Doctor Simon Keely, Doctor Steven Maltby, Doctor Andrew Jarnicki, Doctor Malcolm Starkey, Doctor Adam Collison, Doctor Shaan Gellatly
Scheme Equipment Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1500861
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Hypoxia Chamber –Glovebox$22,000

Funding body: Faculty of Health, University of Newcastle

Funding body Faculty of Health, University of Newcastle
Scheme Equipment GRant
Role Lead
Funding Start 2014
Funding Finish 2015
GNo
Type Of Funding Internal
Category INTE
UON N

The role of the microbiome in the development of food allergy$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Simon Keely, Doctor Jay Horvat
Scheme Project Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1301344
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Experimental Biology 2014, San Diego USA, 26-30 April 2014$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Simon Keely
Scheme Travel Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400253
Type Of Funding Internal
Category INTE
UON Y

20132 grants / $22,000

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
Scheme Equipment Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1201186
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

United European Gastroenterology Week, Berlin, 12 -16 October 2013$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Simon Keely
Scheme Travel Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300842
Type Of Funding Internal
Category INTE
UON Y

20124 grants / $444,226

The Role of Hypoxia in Wound Healing During Mucosal Inflammation$312,726

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Simon Keely
Scheme Project Grant
Role Lead
Funding Start 2012
Funding Finish 2014
GNo G1100095
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Karl Storz, Small animal endoscopy suite$80,000

Funding body: Faculty of Health, University of Newcastle

Funding body Faculty of Health, University of Newcastle
Scheme Faculty of Health, Equipment Grant
Role Lead
Funding Start 2012
Funding Finish 2015
GNo
Type Of Funding Internal
Category INTE
UON N

SpectraMax M5e Multi-Mode Microplate Reader$50,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Linda Howland, Doctor Kelly Asquith
Scheme Equipment Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100975
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Experimental Biology 2012, San Diego, USA, 21 - 25 April 2012$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Simon Keely
Scheme Travel Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200426
Type Of Funding Internal
Category INTE
UON Y

20112 grants / $46,500

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Laureate Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100037
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Gastrointestinal Tract: XIV: Stems Cells, Adaptation, Inflammation and Cancer, Steamboat Sprngs, Colorado, USA, 14 - 18 August 2011$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Simon Keely
Scheme Travel Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1100679
Type Of Funding Internal
Category INTE
UON Y

20092 grants / $335,500

Influence of Hypoxia and HIF Activation on Intestinal Epithelial Restitution via Integrin Signaling$175,500

Funding body: Crohn's and Colitis Foundation of America

Funding body Crohn's and Colitis Foundation of America
Project Team

Simon Keely

Scheme Research Fellowship
Role Lead
Funding Start 2009
Funding Finish 2011
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Microbiome adaption during intestinal fluid transport$160,000

Funding body: Takeda Pharmaceuticals North America, Inc

Funding body Takeda Pharmaceuticals North America, Inc
Project Team

Sean Colgan

Scheme Investigator Initiated - Sponsored Research
Role Investigator
Funding Start 2009
Funding Finish 2011
GNo
Type Of Funding Not Known
Category UNKN
UON N

20071 grants / $60,000

Influence of intestinal fluid transport on bacterial invasion.$60,000

Funding body: Takeda Pharmaceuticals North America, Inc

Funding body Takeda Pharmaceuticals North America, Inc
Project Team

Sean Colgan

Scheme Investigator Initiated - Sponsored Research
Role Investigator
Funding Start 2007
Funding Finish 2008
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N
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Research Supervision

Number of supervisions

Completed1
Current7

Total current UON EFTSL

PhD2.68

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2016 PhD Modulation of Emotion by Gut Signals to the Brain
PhD (Anatomy), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Hypoxia Inducible Factor (HIF)-1 mediates epithelial wound healing through integrin regulation
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2013 PhD Investigation of the pathogenesis and potential therapeutic interventions of influenza in Asthma and COPD
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD Investigation of Visceral Sensory Processing Mechanisms in the Superficial Dorsal Horn of the Spinal Cord
PhD (Anatomy), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD Mechanisms of Predisposition to Secondary Bacterial Pneumonia
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD The Role of Innate Cells in Infectious Exacerbation of COPD
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD Mechanisms of Lung Inflammation Associated with Inflammatory Bowel Disease
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2016 PhD Investigation of Pathogenesis of Chronic Obstructive Pulmonary Disease
PhD (Immunology & Microbiol), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
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Research Opportunities

Honours Project

Immunology of Colorectal Cancer - including cell biology, animal models and microbiology

Honours

Hunter Medical Research Institute - VIVA

8/10/2015 - 30/11/2016

Contact

Doctor Simon Keely
University of Newcastle
School of Biomedical Sciences and Pharmacy
simon.keely@newcastle.edu.au

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Dr Simon Keely

Position

Senior Lecturer
Gastrointestinal Research Group
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Immunology and Microbiology

Contact Details

Email simon.keely@newcastle.edu.au
Phone (02) 4042 0229 (HMRI)
Fax (02) 4042 0026 (HMRI)

Office

Room Rm 2413, Level 2 East Wing (HMRI) LS2-39 (Callaghan)
Building HMRI - Life Sciences Building (Callaghan)
Location Hunter Medical Research Institute and Callaghan Campus
University Drive
Callaghan, NSW 2308
Australia
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