Staff Profile

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Career Summary

Biography

Dr. Keely graduated with a Ph.D. from University College Dublin. He undertook postdoctoral research training at the Mucosal Inflammation Program in University of Colorado Denver before being promoted to junior faculty positions (Instructor and Senior Instructor) in the School of Medicine and receiving a prestigious fellowship from the Crohn's and Colitis Foundation of America.

Dr. Keely is chief investigator of the Hunter Medical Research Institute (HMRI) Gastrointestinal Research Group. The group's current research examines molecular mechanisms of disease in the gastrointestinal tract. Dr. Keely is particularly interested in how the mucosal tissues function and repair with reduced oxygen availability during inflammation. Dr. Keely is also interested in the changes that occur with microbial interactions during inflammation and how these interactions influence the progression and resolution of mucosal diseases. The ultimate goal of this research is understanding how these factors may be pharmacologically manipulated for therapeutic benefit.

Research

Research keywords

  • Crohn's Disease
  • Epithelial Biology
  • Hypoxia
  • Immunology
  • Infection
  • Inflammatory Bowel Disease
  • Mucosal Inflammation
  • Ulcerative Colitis

Research expertise

The Gastrointestinal Research Group is focused on studying the cellular processes of digestive disease and infection.

The group is particularly interested in mucosal inflammation and how tissues adapt to conditions of oxygen deficiency (hypoxia) in inflamed tissue. This is particularly relevant to chronic inflammatory diseases such as the inflammatory bowel diseases (IBD); Crohn's disease & ulcerative colitis.

To achieve this, we study cellular mechanisms of inflammation and adaption to inflammation in vitro. We give our findings physiological context by applying them to in vivo models of IBD and then, through our collaborators at John Hunter Hospital, examine human context in patient samples. With this approach, we hope to identify strategies for new therapeutic approaches to treating IBD.

Our current, ongoing research:

1) Investigates how wound healing is regulated in the intestine during the inflammation associated with Crohn's disease.

2) Examines the mechanisms leading to IBD-related disease that occurs outside of the gastrointestinal tract.

3) Explores how a new experimental drug, which promotes accelerated remission, regulates the immune system in models of IBD.

4) Examines how pain is regulated in the intestines in chronic IBD.

Languages

  • English
  • Irish

Fields of Research

CodeDescriptionPercentage
060199Biochemistry And Cell Biology Not Elsewhere Classified35
110307Gastroenterology And Hepatology35
110799Immunology Not Elsewhere Classified30

Memberships

Body relevant to professional practice.

  • Member - Australian Society for Immunology
  • Member - Gastroenterological Society of Australia

NHMRC Committee

  • Member - NHMRC GRP

Appointments

Senior Instructor
University of Colorado, Denver, USA (United States)
01/12/2009 - 01/02/2011
Instructor
University of Colorado, Denver, USA (United States)
01/12/2008 - 01/12/2009

Awards

Research Award.

2009Research Fellowship
Crohn's & Colitis Foundation of America (United States)
Support for IBD related research

Collaboration

Professor Phil Hansbro, University of Newcastle

Professor Alan Baird, University College Dublin, Ireland

Professor Sean Colgan, University of Colorado Denver, Colorado, USA

Professor Robert Callister, University of Newcastle

Dr. Jay Horvat, University of Newcastle

Administrative

Administrative expertise

Broad expertise and experience in administration and committee panels. Served on international conference and workshop review committees, school and faculty executives and focus group panels.

Member of Institutional Biosafety Committee

Course Co-ordinator for HUBS3204

NHMRC Grant Review Panel Member 2012

Teaching

Teaching keywords

  • Cell Biology
  • Immunology
  • Microbiology
  • Molecular Biology

Teaching expertise

My teaching covers topics of Immunology, Microbiology and Scientific Skills and Development across a range of degree courses and modules.

For 2012 I teach into the following Biomedical Science courses:

http://www.newcastle.edu.au/course/HUBS1404.html HUBS1404 Biomedical Science 2

http://www.newcastle.edu.au/course/HUBS1416.html HUBS1416 Advanced Human Bioscience

http://www.newcastle.edu.au/course/HUBS2601.html HUBS2601 Human Infection and Immunity 1

http://www.newcastle.edu.au/course/HUBS3602.html HUBS3602 Human Infection and Immunity 2

http://www.newcastle.edu.au/course/HUBS3204.html HUBS3204 Advanced Professional Skills in Biomedical Science

In addition I present courses into:

http://www.newcastle.edu.au/course/MEDI1015.html MEDI1015 Medical Science 1

http://www.newcastle.edu.au/course/MEDI2014.html MEDI2014 Medical Science 2

http://www.newcastle.edu.au/course/MEDI3018.html MEDI3018 Medical Science 3

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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2014Keely S, Campbell EL, Baird AW, Hansbro PM, Shalwitz RA, Kotsakis A, et al., 'Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis', MUCOSAL IMMUNOLOGY, 7 114-123 (2014)
2009Keely S, Glover L, Macmanus C, Campbell E, Scully M, Furuta G, Colgan S, 'Selective induction of integrin beta1 by hypoxia-inducible factor: implications for wound healing.', The FASEB Journal, 23 1338-1346 (2009) [C1]
2008Robinson A, Keely S, Karhausen J, Gerich M, Furuta G, Colgan S, 'Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition.', Gastroenterology, 134 346-348 (2008) [C1]
2010Keely S, Glover L, Weissmueller T, Macmanus C, Fillon S, Fennimore B, Colgan S, 'Hypoxia-inducible factor-dependent regulation of platelet-activating factor receptor as a route for gram-positive bacterial translocation across epithelia', Molecular Biology of the Cell, 21 538-546 (2010) [C1]
2012Keely S, Talley NJ, Hansbro PM, 'Pulmonary-intestinal cross-talk in mucosal inflammatory disease', Mucosal Immunology, 5 7-18 (2012) [C1]
2005Keely S, Atvinder R, Wilson C, Carmichael A, Carrington S, Corfield A, et al., 'In vitro and ex vivo intestinal tissue models to measure mucoadhesion of poly (methacrylate) and N-trimethylated chitosan polymers.', Pharmaceutical Research, 22 38-49 (2005) [C1]
2009Keely S, Ryan S, Haddleton D, Limer A, Mantovani G, Murphy E, Brayden D, 'Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers.', Journal of Controlled Release, 135 35-43 (2009) [C1]
2011Kominsky D, Keely S, Macmanus C, Glover L, Scully M, Collins C, et al., 'An Endogenously Anti-Inflammatory Role for Methylation in Mucosal Inflammation Identified through Metabolite Profiling.', Journal of Immunology, 186 6505-6514 (2011) [C1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (24 outputs)

YearCitationAltmetricsLink
2014Farrell KE, Keely S, Graham BA, Callister R, Callister RJ, 'A Systematic Review of the Evidence for Central Nervous System Plasticity in Animal Models of Inflammatory-mediated Gastrointestinal Pain', INFLAMMATORY BOWEL DISEASES, 20 176-195 (2014) [C1]
2014Ward JBJ, Keely SJ, Keely SJ, 'O2 in the regulation of intestinal epithelial transport', The Journal of Physiology, (2014)
2014Keely S, Campbell EL, Baird AW, Hansbro PM, Shalwitz RA, Kotsakis A, et al., 'Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis', MUCOSAL IMMUNOLOGY, 7 114-123 (2014)
2014Keely S, Hansbro PM, 'Lung-gut cross talk : A potential mechanism for intestinal dysfunction in patients with COPD', Chest, 145 199-200 (2014)
2014Farrell KE, Callister RJ, Keely S, 'Understanding and targeting centrally mediated visceral pain in inflammatory bowel disease', Frontiers in Pharmacology, 5 (2014)
2013Goggins BJ, Chaney C, Radford-Smith GL, Horvat JC, Keely S, 'Hypoxia and Integrin-Mediated Epithelial Restitution during Mucosal Inflammation.', Front Immunol, 4 272 (2013) [C1]
2013Beckett EL, Stevens RL, Jarnicki AG, Kim RY, Hanish I, Hansbro NG, et al., 'A new short-term mouse model of chronic obstructive pulmonary disease identifies a role for mast cell tryptase in pathogenesis', The Journal of Allergy and Clinical Immunology, 131 752-762 (2013) [C1]
2012Keely S, Kelly CJ, Weissmueller T, Burgess A, Wagner BD, Robertson CE, et al., 'Activated fluid transport regulates bacterial-epithelial interactions and significantly shifts the murine colonic microbiome', Gut Microbes, 3 1-11 (2012) [C1]
2012Keely S, Talley NJ, Hansbro PM, 'Pulmonary-intestinal cross-talk in mucosal inflammatory disease', Mucosal Immunology, 5 7-18 (2012) [C1]
2011Kominsky D, Keely S, Macmanus C, Glover L, Scully M, Collins C, et al., 'An Endogenously Anti-Inflammatory Role for Methylation in Mucosal Inflammation Identified through Metabolite Profiling.', Journal of Immunology, 186 6505-6514 (2011) [C1]
2011Keely S, Feighery L, Campion DP, O'Brien L, Brayden DJ, Baird AW, 'Chloride-led disruption of the intestinal mucous layer impedes salmonella invasion: Evidence for an 'enteric tear' mechanism', Cellular Physiology and Biochemistry, 28 743-752 (2011) [C1]
2011Macmanus C, Campbell E, Keely S, Adrienne B, Kominsky D, Colgan S, 'Anti-inflammatory actions of adrenomedullin through fine tuning of HIF stabilization', The FASEB Journal, 25 1856-1864 (2011) [C1]
2010Keely S, Glover L, Weissmueller T, Macmanus C, Fillon S, Fennimore B, Colgan S, 'Hypoxia-inducible factor-dependent regulation of platelet-activating factor receptor as a route for gram-positive bacterial translocation across epithelia', Molecular Biology of the Cell, 21 538-546 (2010) [C1]
2010Campbell E, Macmanus C, Kominsky D, Keely S, Glover L, Scully M, et al., 'Resolvin E1-induced Intestinal Alkaline Phosphatase Promotes Resolution of Inflammation through LPS detoxification.', Proceedings of the National Academy of Sciences of USA, 107 4298-4303 (2010) [C1]
2009Keely S, Ryan S, Haddleton D, Limer A, Mantovani G, Murphy E, Brayden D, 'Dexamethasone-pDMAEMA polymeric conjugates reduce inflammatory biomarkers in human intestinal epithelial monolayers.', Journal of Controlled Release, 135 35-43 (2009) [C1]
2009Keely S, Glover L, Macmanus C, Campbell E, Scully M, Furuta G, Colgan S, 'Selective induction of integrin beta1 by hypoxia-inducible factor: implications for wound healing.', The FASEB Journal, 23 1338-1346 (2009) [C1]
2008Feighery L, Smyth A, Keely S, Baird A, O'Connor W, Callanan J, Brayden D, 'Increased intestinal permeability in rats subjected to traumatic frontal lobe percussion brain injury.', Journal of Trauma: Injury Infection and Critical Care, 64 131-137 (2008) [C1]
2008Boland T, Hayes L, Sweeney T, Callanan J, Baird A, Keely S, Crosby T, 'The effects of cobalt and iodine supplementation of the pregnant ewe diet on immunoglobulin G, vitamin E, T-3 and T-4 levels in the progeny.', Animal: the international journal of animal biosciences, 2 197-206 (2008) [C1]
2008Keely S, Rawlinson L-A, Haddleton D, Brayden D, 'Tertiary Amino-Containing Polymethacrylate Polymer Protects Mucus-Covered Intestinal Epithelial Monolayers Against Pathogenic Challenge', Pharmaceutical Research, 25 1193-1201 (2008) [C1]
2008Robinson A, Keely S, Karhausen J, Gerich M, Furuta G, Colgan S, 'Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition.', Gastroenterology, 134 346-348 (2008) [C1]
2008Keely S, Rawlinson L-AB, Haddleton DM, Brayden DJ, 'A tertiary amino-containing polymethacrylate polymer protects mucus-covered intestinal epithelial monolayers against pathogenic challenge', PHARMACEUTICAL RESEARCH, 25 1193-1201 (2008) [C1]
2008Fanning R, Campion D, Collins C, Keely S, Briggs L, O'Connor J, Carey M, 'A comparison of the inhibitory effects of bupivacaine and levobupivacaine on isolated human pregnant myometrium contractility.', Anesthesia and Analgesia, 107 1303-1307 (2008) [C1]
2006Limer A, Attvinder R, San Miguel V, Peinado C, Keely S, Fitzpatrick E, et al., 'Fluorescently tagged star polymers by living radical polymerisation for mucoadhesion and bioadhesion.', Reactive and Functional Polymers, 66 51-64 (2006) [C1]
2005Keely S, Atvinder R, Wilson C, Carmichael A, Carrington S, Corfield A, et al., 'In vitro and ex vivo intestinal tissue models to measure mucoadhesion of poly (methacrylate) and N-trimethylated chitosan polymers.', Pharmaceutical Research, 22 38-49 (2005) [C1]
Show 21 more

Conference (11 outputs)

YearCitationAltmetricsLink
2013Hansbro P, Beckett E, Stevens R, Jarnicki A, Kim R, Hanish I, et al., 'A short-term model of COPD identifies a role for mast cell tryptase', JOURNAL OF IMMUNOLOGY, Honolulu, HI (2013) [E3]
2012Keely S, Baird A, Kominsky D, McNamee EN, Hansbro PM, Shalwitz RA, Colgan SP, 'Immune modulation by prolyl hydroxylase inhibition contributes to the prevention of endotoxemia in a murine model of inflammatory bowel disease', FASEB Journal, San Diego, California (2012) [E3]

Co-authors: Philip Hansbro

2012Nolan GM, Minahan KL, Farrell KE, Chaney C, Mateer S, Talley NJ, Keely S, 'Hypoxia-inducible factor-1 a promotes mucosal protection in colitis via the IL-12 signalling pathway', Journal of Gastroenterology and Hepatology, Adelaide, S.A. (2012) [E3]

Co-authors: Nicholas Talley

2012Farrell KE, Keely S, Graham BA, Minahan KL, Madden JF, Callister RJ, 'Spinal cord signalling in a mouse model of inflammatory bowel disease', Journal of Gastroenterology and Hepatology, Adelaide, SA (2012) [E3]
2012Mateer S, Hansbro PM, Nolan GM, Chaney C, Minahan KL, Keely S, 'Development of pulmonary inflammation and altered lung function in a mouse model of colitis', Journal of Gastroenterology and Hepatology, Adelaide, S.A. (2012) [E3]

Co-authors: Philip Hansbro

2012Keely S, Baird AW, Colgan S, 'Epithelial HIF-1 a is critical to the protective action of prolyl hydroxylase inhibition in a murine model of inflammatory bowel disease', Journal of Gastroenterology and Hepatology, Adelaide, S.A. (2012) [E3]
2012Chaney C, Minahan KL, Mateer S, Nolan GM, Talley NJ, Keely S, 'Hypoxic regulation of ß1 integrin during mucosal wound healing', Journal of Gastroenterology and Hepatology, Adelaide, S.A. (2012) [E3]

Co-authors: Nicholas Talley

2011Kominsky D, Keely S, Campbell E, Christopher M, Scully M, Collins C, et al., 'A central role of methylation in mucosal inflammation', Inflammatory Bowel Diseases, Hollywood, Florida (2011) [E3]
2011Keely S, Baird A, Kominsky D, Campbell E, Burgess A, Colgan S, 'HIF prolyl hydroxylase inhibition reverses disease symptoms in established TNBS colitis', Inflammatory Bowel Diseases, Hollywood, Florida (2011) [E3]
2011Kominsky D, Keely S, Macmanus C, Glover L, Scully M, Collins C, et al., 'Cellular methylation plays an anti-inflammatory role in Mucosal Inflammation', Inflammatory Bowel Diseases, Hollywood, Florida (2011) [E3]
2011Campbell E, Macmanus C, Kominsky D, Keely S, Glover L, Bowers B, et al., 'Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification', Inflammatory Bowel Diseases, Hollywood, Florida (2011) [E3]
Show 8 more
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Grants and Funding

Summary

Number of grants13
Total funding$1,386,452

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (3 grants)

Spinal processing of sensory signals from the gut$536,226
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Robert Callister, Doctor Simon Keely, Doctor Brett Graham, Associate Professor Alan Brichta, Dr David Hughes
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$536,22620142016
GNo:G1300361

The role of the microbiome in the development of food allergy$20,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Simon Keely, Doctor Jay Horvat
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020142014
GNo:G1301344

Experimental Biology 2014, San Diego USA, 26-30 April 2014$2,000
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Simon Keely
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,00020142014
GNo:G1400253

2013 (2 grants)

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020132013
GNo:G1201186

United European Gastroenterology Week, Berlin, 12 -16 October 2013$2,000
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Simon Keely
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,00020132013
GNo:G1300842

2012 (3 grants)

The Role of Hypoxia in Wound Healing During Mucosal Inflammation$312,726
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Simon Keely
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$312,72620122014
GNo:G1100095

SpectraMax M5e Multi-Mode Microplate Reader$50,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Paul Foster, Professor Phil Hansbro, Professor Joerg Mattes, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Linda Howland, Doctor Kelly Asquith
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$50,00020122012
GNo:G1100975

Experimental Biology 2012, San Diego, USA, 21 - 25 April 2012$1,500
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Simon Keely
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,50020122012
GNo:G1200426

2011 (2 grants)

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Phil Hansbro, Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$45,00020112011
GNo:G1100037

Gastrointestinal Tract: XIV: Stems Cells, Adaptation, Inflammation and Cancer, Steamboat Sprngs, Colorado, USA, 14 - 18 August 2011$1,500
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Simon Keely
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,50020112011
GNo:G1100679

2009 (2 grants)

Influence of Hypoxia and HIF Activation on Intestinal Epithelial Restitution via Integrin Signaling$175,500
Funding Body: Crohn's and Colitis Foundation of America

SchemeRole
Research FellowshipChief Investigator
Total AmountFunding StartFunding Finish
$175,50020092011
GNo:162014934

Microbiome adaption during intestinal fluid transport$160,000
Funding Body: Takeda Pharmaceuticals North America, Inc

SchemeRole
Investigator Initiated - Sponsored ResearchInvestigator
Total AmountFunding StartFunding Finish
$160,00020092011
GNo:162014922

2007 (1 grants)

Influence of intestinal fluid transport on bacterial invasion.$60,000
Funding Body: Takeda Pharmaceuticals North America, Inc

SchemeRole
Investigator Initiated - Sponsored ResearchInvestigator
Total AmountFunding StartFunding Finish
$60,00020072008
GNo:162014910
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Research Supervision

Number of current supervisions8
Total current UoN PhD EFTSL2.58

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20142018PhD (Pharmacy)Co-SupervisorPeripheral Opioid Receptor Targeting for the Relief of Pain, Inflammation and Disease Progression in Rheumatoid Arthritis
20142018PhD (Immunology & Microbiol)Principal SupervisorHypoxic Regulation of Integrin Beta1 During Mucosal Wound Healing
20132017PhD (Immunology & Microbiol)Co-SupervisorInvestigation of the pathogenesis and potential therapeutic interventions of influenza in Asthma and COPD
20112015PhD (Immunology & Microbiol)Principal SupervisorIdentifying the Mechanisms of Lung Inflammation Associated with Inflammatory Bowel Disease
20112015PhD (Immunology & Microbiol)Co-SupervisorMechanisms of Predisposition to Secondary Bacterial Pneumonia
20112015PhD (Immunology & Microbiol)Co-SupervisorThe Role of Innate Cells in Infectious Exacerbation of COPD
20112015PhD (Immunology & Microbiol)Co-SupervisorInvestigation of Pathogenesis of Chronic Obstructive Pulmonary Disease (COPD)
20112015PhD (Anatomy)Co-SupervisorSpinal Cord Signalling in a Mouse Model of IBD
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Dr Simon Keely

Work Phone(02) 4042 0229 (HMRI)
Fax(02) 4042 0026 (HMRI)
Email
PositionSenior Lecturer
Gastrointestinal Research Group
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaImmunology and Microbiology
Office
Rm 2413, Level 2 East Wing (HMRI) LS2-39 (Callaghan) ,
HMRI - Life Sciences Building (Callaghan),
Hunter Medical Research Institute and Callaghan Campus
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/