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Dr Steven Maltby

Postdoctoral Research Fellow

School of Biomedical Sciences and Pharmacy

Career Summary

Biography

My current research focus is aimed at characterizing changes in the bone marrow during disease and infection. During a virus infection, an immune response is rapidly induced. This immune response is required to kill the virus and infected cells.  However, the immune response often also causes a lot of the damage and pathology that is observed.

The aim of our studies is to characterise what happens when a virus is first detected by the immune system, including systemic changes in the bone marrow. The bone marrow houses immune cell progentors that give rise to mature immune cells, as well as structural cells that are important for maintaining mineral bone. Our second aim is to identify key molecules involved in feedback from sites of infection/inflammation to the bone marrow and the impacts of blocking these molecules on disease pathology.

I completed my PhD studies with Dr Kelly McNagny at The Biomedical Research Centre, University of British Columbia in Vancouver, BC, Canada. My research focused on the role of CD34 (and the related molecule podocalyxin) in immune responses, using mouse models of disease. Those studies identified the importance of CD34 for efficient eosinophil and mast cell migration to sites of inflammation during disease. Further, I demonstrated that loss of CD34 expression (using transgenic Cd34-/- animals) resulted in reduced disease severity in mouse models of asthma and ulcerative colitis.

Research Expertise
Main Research Focus Areas: Bone Marrow Responses MicroRNA Regulation Immune Cell Activation and Migration Virus Infections

Teaching Expertise
Immunology


Qualifications

  • PhD, University of British Columbia - Canada
  • Bachelor of Science, University of British Columbia - Canada

Keywords

  • Asthma
  • Bone Marrow
  • Disease Models
  • Hematopoiesis
  • Immunology
  • Infection
  • Virus

Languages

  • English (Fluent)

Fields of Research

Code Description Percentage
110309 Infectious Diseases 30
110316 Pathology (excl. Oral Pathology) 20
110799 Immunology not elsewhere classified 50

Professional Experience

Academic appointment

Dates Title Organisation / Department
1/01/2012 - 1/12/2015 Fellow UON

UoN Research Fellowship

University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/07/2010 - 1/09/2011 Post-doctoral fellow University of British Columbia
The Biomedical Research Centre
Canada

Awards

Research Award

Year Award
2012 Postdoctoral Research Fellowship
Canadian Institutes of Health Research
2012 Postdoctoral Research Fellowship
University of Newcastle
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (6 outputs)

Year Citation Altmetrics Link
2015 Maltby S, Plank M, Ptaschinski C, Mattes J, Foster PS, 'Microrna function in mast cell biology: protocols to characterize and modulate microrna expression', , Humana Press Inc. 287-304 (2015)

MicroRNAs (miRNAs) are small noncoding RNA molecules that can modulate mRNA levels through RNA-induced silencing complex (RISC)-mediated degradation. Recognition of target mRNAs o... [more]

MicroRNAs (miRNAs) are small noncoding RNA molecules that can modulate mRNA levels through RNA-induced silencing complex (RISC)-mediated degradation. Recognition of target mRNAs occurs through imperfect base pairing between an miRNA and its target, meaning that each miRNA can target a number of different mRNAs to modulate gene expression. miRNAs have been proposed as novel therapeutic targets and many studies are aimed at characterizing miRNA expression patterns and functions within a range of cell types. To date, limited research has focused on the function of miRNAs specifi cally in mast cells; however, this is an emerging fi eld. In this chapter, we will briefl y overview miRNA synthesis and function and the current understanding of miRNAs in hematopoietic development and immune function, emphasizing studies related to mast cell biology. The chapter will conclude with fundamental techniques used in miRNA studies, including RNA isolation, real-time PCR and microarray approaches for quantifi cation of miRNA expression levels, and antagomir design to interfere with miRNA function.

DOI 10.1007/978-1-4939-1568-2_18,
Co-authors Paul Foster, Joerg Mattes
2015 Maltby S, Plank M, Ptaschinski C, Mattes J, Foster PS, 'Microrna function in mast cell biology: protocols to characterize and modulate microrna expression', , Humana Press Inc. 287-304 (2015)
DOI 10.1007/978-1-4939-1568-2_18,
Co-authors Paul Foster, Joerg Mattes
2015 Maltby S, Plank M, Ptaschinski C, Mattes J, Foster PS, 'MicroRNA function in mast cell biology: protocols to characterize and modulate microRNA expression', 287-304 (2015)

MicroRNAs (miRNAs) are small noncoding RNA molecules that can modulate mRNA levels through RNA-induced silencing complex (RISC)-mediated degradation. Recognition of target mRNAs o... [more]

MicroRNAs (miRNAs) are small noncoding RNA molecules that can modulate mRNA levels through RNA-induced silencing complex (RISC)-mediated degradation. Recognition of target mRNAs occurs through imperfect base pairing between an miRNA and its target, meaning that each miRNA can target a number of different mRNAs to modulate gene expression. miRNAs have been proposed as novel therapeutic targets and many studies are aimed at characterizing miRNA expression patterns and functions within a range of cell types. To date, limited research has focused on the function of miRNAs specifically in mast cells; however, this is an emerging field. In this chapter, we will briefly overview miRNA synthesis and function and the current understanding of miRNAs in hematopoietic development and immune function, emphasizing studies related to mast cell biology. The chapter will conclude with fundamental techniques used in miRNA studies, including RNA isolation, real-time PCR and microarray approaches for quantification of miRNA expression levels, and antagomir design to interfere with miRNA function.

DOI 10.1007/978-1-4939-1568-2_18
Co-authors Joerg Mattes, Paul Foster
2015 Maltby S, Plank M, Ptaschinski C, Mattes J, Foster PS, 'MicroRNA function in mast cell biology: protocols to characterize and modulate microRNA expression', 287-304 (2015)

MicroRNAs (miRNAs) are small noncoding RNA molecules that can modulate mRNA levels through RNA-induced silencing complex (RISC)-mediated degradation. Recognition of target mRNAs o... [more]

MicroRNAs (miRNAs) are small noncoding RNA molecules that can modulate mRNA levels through RNA-induced silencing complex (RISC)-mediated degradation. Recognition of target mRNAs occurs through imperfect base pairing between an miRNA and its target, meaning that each miRNA can target a number of different mRNAs to modulate gene expression. miRNAs have been proposed as novel therapeutic targets and many studies are aimed at characterizing miRNA expression patterns and functions within a range of cell types. To date, limited research has focused on the function of miRNAs specifically in mast cells; however, this is an emerging field. In this chapter, we will briefly overview miRNA synthesis and function and the current understanding of miRNAs in hematopoietic development and immune function, emphasizing studies related to mast cell biology. The chapter will conclude with fundamental techniques used in miRNA studies, including RNA isolation, real-time PCR and microarray approaches for quantification of miRNA expression levels, and antagomir design to interfere with miRNA function.

DOI 10.1007/978-1-4939-1568-2_18
Co-authors Paul Foster, Joerg Mattes
2015 Maltby S, Plank M, Ptaschinski C, Mattes J, Foster PS, 'MicroRNA function in mast cell biology: protocols to characterize and modulate microRNA expression.', 287-304 (2015)
DOI 10.1007/978-1-4939-1568-2_18
Co-authors Joerg Mattes, Paul Foster
2013 Maltby S, McNagny KM, Ackerman SJ, Du J, Mori Y, Iwasaki H, et al., 'Eosinophilopoiesis', Eosinophils in Health and Disease, Elsevier Inc. 73-119 (2013) [B2]
DOI 10.1016/B978-0-12-394385-9.00005-5
Show 3 more chapters

Journal article (11 outputs)

Year Citation Altmetrics Link
2015 Tay HL, Kaiko GE, Plank M, Li J, Maltby S, Essilfie AT, et al., 'Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung.', PLoS pathogens, 11 e1004549 (2015)
DOI 10.1371/journal.ppat.1004549
Co-authors Joerg Mattes, Paul Foster, Philip Hansbro
2015 Tay HL, Kaiko GE, Plank M, Li J, Maltby S, Essilfie AT, et al., 'Correction: Antagonism of miR-328 Increases the Antimicrobial Function of Macrophages and Neutrophils and Rapid Clearance of Non-typeable Haemophilus Influenzae (NTHi) from Infected Lung.', PLoS Pathog, 11 e1004956 (2015)
DOI 10.1371/journal.ppat.1004956
2015 Li JJ, Tay HL, Maltby S, Xiang Y, Eyers F, Hatchwell L, et al., 'MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity.', J Allergy Clin Immunol, 136 462-473 (2015)
DOI 10.1016/j.jaci.2014.11.044
Co-authors Paul Foster, Joerg Mattes
2014 Maltby S, Hansbro NG, Tay HL, Stewart J, Plank M, Donges B, et al., 'Production and differentiation of myeloid cells driven by proinflammatory cytokines in response to acute pneumovirus infection in mice.', J Immunol, 193 4072-4082 (2014) [C1]
DOI 10.4049/jimmunol.1400669
Co-authors Paul Foster, Nicole Hansbro
2012 Maltby SJ, Debruin EJ, Bennett J, Gold MJ, Tunis MC, Jian Z, et al., 'IL-7Ra and L-selectin, but not CD103 or CD34, are required for murine peanut-induced anaphylaxis', Allergy Asthma and Clinical Immunology, 8 15-25 (2012) [C1]
DOI 10.1186/1710-1492-8-15
Citations Scopus - 1Web of Science - 1
2011 Maltby SJ, Freeman S, Gold MJ, Baker JH, Minchinton AI, Gold MR, et al., 'Opposing Roles for CD34 in B16 Melanoma Tumor Growth Alter Early Stage Vasculature and Late Stage Immune Cell Infiltration', PLoS One, 6 (2011) [C1]
DOI 10.1371/journal.pone.0018160
Citations Scopus - 10Web of Science - 8
2010 Maltby SJ, Wohlfarth C, Gold M, Zbytnuik L, Hughes MR, McNagny KM, 'CD34 is required for infiltration of eosinophils into the colon and pathology associated with DSS-induced ulcerative colitis', American Journal of Pathology, 177 1244-1254 (2010) [C1]
DOI 10.2353/ajpath.2010.100191
Citations Scopus - 16Web of Science - 14
2010 Blanchet M-R, Gold M, Maltby SJ, Bennett J, Petri B, Kubes P, et al., 'Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability', Journal of Immunology, 184 1292-1299 (2010) [C1]
DOI 10.4049/?jimmunol.0900808
Citations Scopus - 13Web of Science - 15
2010 Maltby SJ, Wong J, Berberovic Z, Birkenmeier CS, Haddon DJ, Garcha K, et al., 'A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe, hemolytic hereditary spherocytosis', Experimental Hematology, 39 601-610 (2010) [C1]
DOI 10.1016/j.exphem.2010.12.009
Citations Scopus - 13Web of Science - 10
2009 Maltby SJ, Hughes MR, Zbytnuik L, Paulson RF, McNagny KM, 'Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery', Experimental Hematology, 37 10-18 (2009) [C1]
DOI 10.1016/j.exphem.2008.09.006
Citations Scopus - 4Web of Science - 4
2007 Blanchet M-R, Maltby SJ, Haddon DJ, Merkens H, Zbytnuik L, McNagny KM, 'CD34 facilitates the development of allergic asthma', Blood, 110 2005-2012 (2007) [C1]
Citations Scopus - 38Web of Science - 38
Show 8 more journal articles

Review (3 outputs)

Year Citation Altmetrics Link
2013 Plank M, Maltby S, Mattes J, Foster PS, 'Targeting translational control as a novel way to treat inflammatory disease: The emerging role of MicroRNAs', Clinical and Experimental Allergy (2013) [C1]

Chronic inflammatory diseases (e.g. asthma and chronic obstructive pulmonary disease) are leading causes of morbidity and mortality world-wide and effective treatments are limited... [more]

Chronic inflammatory diseases (e.g. asthma and chronic obstructive pulmonary disease) are leading causes of morbidity and mortality world-wide and effective treatments are limited. These disorders can often be attributed to abnormal immune responses to environmental stimuli and infections. Mechanisms leading to inflammation are complex, resulting from interactions of structural cells and activation of both the adaptive and innate arms of the immune system. The activation of structural and immune cells involves both temporary and permanent changes in gene expression in these cells, which underpin chronic inflammation and tissue dysfunction. miRNAs are small non-coding RNAs increasingly being recognized to play important roles in the post-transcriptional regulation of gene expression in mammalian cells by regulating translation. Individual miRNAs can exert their effects by directly inhibiting the translation or stability of multiple mRNAs simultaneously. Thus, the expression or blockade of function of a single miRNA (miR) can result in pronounced alterations in protein expression within a given cell. Dysregulation of miRNA expression may subsequently alter cellular function, and in certain situations predispose to disease. Our current understanding of the role of miRNA in the regulation of inflammatory disease (e.g. allergic diseases) remains limited. In this review, we provide an overview of the current understanding of miRNA biogenesis and function, the roles miRNA play in the regulation of immune cell function and their potential contribution to inflammatory diseases. We also highlight strategies to alter miRNA function for experimental or therapeutic gain, and discuss the potential utility and limitations of targeting these molecules as anti-inflammatory strategies. © 2013 John Wiley & Sons Ltd.

DOI 10.1111/cea.12135
Citations Scopus - 8Web of Science - 6
Co-authors Joerg Mattes, Paul Foster
2013 Plank M, Maltby S, Mattes J, Foster PS, 'Targeting translational control as a novel way to treat inflammatory disease: the emerging role of microRNAs.', Clinical and Experimental Allergy (2013) [C1]
DOI 10.1111/cea.12170
Co-authors Joerg Mattes, Paul Foster
2009 Maltby SJ, Khash K, McNagny KM, 'Mast cells in tumor growth: angiogenesis, tissue remodeling and immune-modulation', Biochimica et biophysica acta - Reviews on Cancer (2009) [D1]
Citations Scopus - 119Web of Science - 102

Conference (7 outputs)

Year Citation Altmetrics Link
2015 Tay H, Kaiko G, Plank M, Li J, Essilfie A, Maltby S, et al., 'THE ROLE OF MIR-328 IN RESPIRATORY DISEASES', RESPIROLOGY (2015)
Co-authors Joerg Mattes, Philip Hansbro
2014 Mateer S, Maltby S, Marks E, Goggins B, Horvat J, Hansbro P, Keely S, 'Immune cell mis-homing drives secondary organ inflammation in inflammatory bowel disease; a focus on the respiratory system', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Philip Hansbro, Simon Keely, Jay Horvat
2012 McNagny K, Debruin E, Gold M, Bennett J, Blanchet M-R, Maltby S, Hughes M, 'CD34 family proteins are key regulators of inflammatory cell migration and vascular integrity', JOURNAL OF IMMUNOLOGY, Boston, MA (2012) [E3]
2011 Maltby S, Gold M, Wohlfarth C, Blanchet M, McNagny KM, 'CD34 LOCALIZATION IN EOSINOPHILS AT STEADY STATE AND DURING DISEASE', EXPERIMENTAL HEMATOLOGY (2011) [E3]
2008 Blanchet M-R, Maltby S, Bennett J, McNagny K, 'Mouse models to study the role of CD34 in allergy and inflammatory diseases', FASEB JOURNAL (2008) [E3]
2007 Hughes MR, Anderson N, Maltby S, Wong J, Milenkovic Z, Wang C, et al., 'A new model of hereditary spherocytosis demonstrates profound homeostatic compensation in severely anemic mice.', BLOOD, Atlanta, GA (2007)
2007 Hughes MR, Maltby S, Zbytnuik L, Paulson R, McNagny KM, 'Podocalyxin is a selective marker of erythroid progenitors but is dispensable for anemia recovery.', BLOOD, Atlanta, GA (2007)
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Grants and Funding

Summary

Number of grants 9
Total funding $585,900

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $1,500

Keystone Symposium: Hematopoiesis, Colorado USA, 22-27 February 2015$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Steven Maltby
Scheme Travel Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1500324
Type Of Funding Internal
Category INTE
UON Y

20143 grants / $44,216

Miltenyi Biotec GentleMACS Octo Dissociator with Heaters $23,566

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Darryl Knight, Professor Dirk Van Helden, Professor Joerg Mattes, Associate Professor Jodie Simpson, Associate Professor Lisa Wood, Associate Professor Liz Milward, Dr NATHAN Bartlett, Doctor Simon Keely, Doctor Steven Maltby, Doctor Andrew Jarnicki, Doctor Malcolm Starkey, Doctor Adam Collison, Ms Shaan Gellatly
Scheme Equipment Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1500861
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Virus Infections Change the Bone Marrow: Effects on Immunity, Bone Development and Inflammatory Disease$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Steven Maltby, Mr Max Plank, Doctor Hock Tay, Laureate Professor Paul Foster
Scheme Project Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1401394
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Inaugural Future of Experimental Medicine Conference: Inflammation in Disease and Ageing, Sydney Australia, 16-19 March 2014$650

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Steven Maltby
Scheme Travel Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400166
Type Of Funding Internal
Category INTE
UON Y

20132 grants / $21,500

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
Scheme Equipment Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1201186
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

43rd Annual Scientific meeting of the Australasian Society for Immunology (ASI), Wellington New Zealand, 2 - 5 December 2013$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Steven Maltby
Scheme Travel Grant
Role Lead
Funding Start 2013
Funding Finish 2014
GNo G1300439
Type Of Funding Internal
Category INTE
UON Y

20123 grants / $518,684

2011 Research Fellowship - DVCR Strategic Appointment (PRCARD)$348,315

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Steven Maltby
Scheme Research Fellowship
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1100534
Type Of Funding Internal
Category INTE
UON Y

Post-Doctoral Research Fellowship$150,000

Funding body: Canadian Institutes of Health Research (CIHR)

Funding body Canadian Institutes of Health Research (CIHR)
Project Team
Scheme Health Research
Role Lead
Funding Start 2012
Funding Finish 2015
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Fellowship Start-up Grant$20,369

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Steven Maltby
Scheme Fellowship Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200114
Type Of Funding Internal
Category INTE
UON Y
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Research Supervision

Number of supervisions

Completed0
Current2

Total current UON EFTSL

PhD0.4

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2012 PhD Roles of Bromodomain and extra terminal (BET) proteins in Suppression of Airway Inflammation
Microbiology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD Understanding the mechanisms of airway hyper-responsiveness in a mouse model of asthma
Microbiology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
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Dr Steven Maltby

Position

Postdoctoral Research Fellow
FOSTER GROUP
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Contact Details

Email steven.maltby@newcastle.edu.au
Phone (02) 404 20173
Fax (02) 404 20025

Office

Room HMRI 2 East
Building HMRI
Location NEWCASTLE

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