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Dr Steven Maltby

Postdoctoral Research Fellow

School of Biomedical Sciences and Pharmacy

Career Summary

Biography

My current research focus is aimed at characterizing changes in the bone marrow during disease and infection. During a virus infection, an immune response is rapidly induced. This immune response is required to kill the virus and infected cells.  However, the immune response often also causes a lot of the damage and pathology that is observed.

The aim of our studies is to characterise what happens when a virus is first detected by the immune system, including systemic changes in the bone marrow. The bone marrow houses immune cell progentors that give rise to mature immune cells, as well as structural cells that are important for maintaining mineral bone. Our second aim is to identify key molecules involved in feedback from sites of infection/inflammation to the bone marrow and the impacts of blocking these molecules on disease pathology.

I completed my PhD studies with Dr Kelly McNagny at The Biomedical Research Centre, University of British Columbia in Vancouver, BC, Canada. My research focused on the role of CD34 (and the related molecule podocalyxin) in immune responses, using mouse models of disease. Those studies identified the importance of CD34 for efficient eosinophil and mast cell migration to sites of inflammation during disease. Further, I demonstrated that loss of CD34 expression (using transgenic Cd34-/- animals) resulted in reduced disease severity in mouse models of asthma and ulcerative colitis.

Research Expertise
Main Research Focus Areas: Bone Marrow Responses MicroRNA Regulation Immune Cell Activation and Migration Virus Infections

Teaching Expertise
Immunology


Qualifications

  • PhD, University of British Columbia - Canada
  • Bachelor of Science, University of British Columbia - Canada

Keywords

  • Asthma
  • Bone Marrow
  • Disease Models
  • Hematopoiesis
  • Immunology
  • Infection
  • Virus

Languages

  • English (Fluent)

Fields of Research

CodeDescriptionPercentage
110309Infectious Diseases30
110316Pathology (excl. Oral Pathology)20
110799Immunology not elsewhere classified50

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
2/03/2015 - 10/07/2015Postdoctoral Research FellowUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
20/03/2012 - 20/03/2012Sessional AcademicUniversity of Newcastle
Centre for Teaching and Learning
Australia

Academic appointment

DatesTitleOrganisation / Department
1/01/2012 - 1/12/2015Fellow UON
UoN Research Fellowship
University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/07/2010 - 1/09/2011Post-doctoral fellowUniversity of British Columbia
The Biomedical Research Centre
Canada

Awards

Research Award

YearAward
2012Postdoctoral Research Fellowship
Canadian Institutes of Health Research
2012Postdoctoral Research Fellowship
University of Newcastle
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (4 outputs)

YearCitationAltmetricsLink
2015Maltby S, Plank M, Ptaschinski C, Mattes J, Foster PS, 'Microrna function in mast cell biology: protocols to characterize and modulate microrna expression', , Humana Press Inc. 287-304 (2015)

MicroRNAs (miRNAs) are small noncoding RNA molecules that can modulate mRNA levels through RNA-induced silencing complex (RISC)-mediated degradation. Recognition of target mRNAs o... [more]

MicroRNAs (miRNAs) are small noncoding RNA molecules that can modulate mRNA levels through RNA-induced silencing complex (RISC)-mediated degradation. Recognition of target mRNAs occurs through imperfect base pairing between an miRNA and its target, meaning that each miRNA can target a number of different mRNAs to modulate gene expression. miRNAs have been proposed as novel therapeutic targets and many studies are aimed at characterizing miRNA expression patterns and functions within a range of cell types. To date, limited research has focused on the function of miRNAs specifi cally in mast cells; however, this is an emerging fi eld. In this chapter, we will briefl y overview miRNA synthesis and function and the current understanding of miRNAs in hematopoietic development and immune function, emphasizing studies related to mast cell biology. The chapter will conclude with fundamental techniques used in miRNA studies, including RNA isolation, real-time PCR and microarray approaches for quantifi cation of miRNA expression levels, and antagomir design to interfere with miRNA function.

DOI10.1007/978-1-4939-1568-2_18,
Co-authorsJoerg Mattes, Paul Foster
2015Maltby S, Plank M, Ptaschinski C, Mattes J, Foster PS, 'Microrna function in mast cell biology: protocols to characterize and modulate microrna expression', , Humana Press Inc. 287-304 (2015)
DOI10.1007/978-1-4939-1568-2_18,
Co-authorsJoerg Mattes, Paul Foster
2015Maltby S, Plank M, Ptaschinski C, Mattes J, Foster PS, 'MicroRNA function in mast cell biology: protocols to characterize and modulate microRNA expression.', 287-304 (2015)
DOI10.1007/978-1-4939-1568-2_18Author URL
Co-authorsPaul Foster, Joerg Mattes
2013Maltby S, McNagny KM, Ackerman SJ, Du J, Mori Y, Iwasaki H, et al., 'Eosinophilopoiesis', Eosinophils in Health and Disease, Elsevier Inc. 73-119 (2013) [B2]
DOI10.1016/B978-0-12-394385-9.00005-5
Show 1 more chapter

Journal article (11 outputs)

YearCitationAltmetricsLink
2015Tay HL, Kaiko GE, Plank M, Li J, Maltby S, Essilfie AT, et al., 'Antagonism of miR-328 increases the antimicrobial function of macrophages and neutrophils and rapid clearance of non-typeable Haemophilus influenzae (NTHi) from infected lung.', PLoS pathogens, 11 e1004549 (2015)
DOI10.1371/journal.ppat.1004549
Co-authorsPaul Foster, Philip Hansbro
2015Tay HL, Kaiko GE, Plank M, Li J, Maltby S, Essilfie AT, et al., 'Correction: Antagonism of miR-328 Increases the Antimicrobial Function of Macrophages and Neutrophils and Rapid Clearance of Non-typeable Haemophilus Influenzae (NTHi) from Infected Lung.', PLoS Pathog, 11 e1004956 (2015)
DOI10.1371/journal.ppat.1004956Author URL
2015Li JJ, Tay HL, Maltby S, Xiang Y, Eyers F, Hatchwell L, et al., 'MicroRNA-9 regulates steroid-resistant airway hyperresponsiveness by reducing protein phosphatase 2A activity.', J Allergy Clin Immunol, (2015)
DOI10.1016/j.jaci.2014.11.044Author URL
Co-authorsPaul Foster
2014Maltby S, Hansbro NG, Tay HL, Stewart J, Plank M, Donges B, et al., 'Production and differentiation of myeloid cells driven by proinflammatory cytokines in response to acute pneumovirus infection in mice.', J Immunol, 193 4072-4082 (2014) [C1]
DOI10.4049/jimmunol.1400669Author URL
Co-authorsPaul Foster, Nicole Hansbro
2012Maltby SJ, Debruin EJ, Bennett J, Gold MJ, Tunis MC, Jian Z, et al., 'IL-7Ra and L-selectin, but not CD103 or CD34, are required for murine peanut-induced anaphylaxis', Allergy Asthma and Clinical Immunology, 8 15-25 (2012) [C1]
DOI10.1186/1710-1492-8-15
CitationsScopus - 1Web of Science - 1
2011Maltby SJ, Freeman S, Gold MJ, Baker JH, Minchinton AI, Gold MR, et al., 'Opposing Roles for CD34 in B16 Melanoma Tumor Growth Alter Early Stage Vasculature and Late Stage Immune Cell Infiltration', PLoS One, 6 (2011) [C1]
DOI10.1371/journal.pone.0018160
CitationsScopus - 10Web of Science - 8
2010Maltby SJ, Wohlfarth C, Gold M, Zbytnuik L, Hughes MR, McNagny KM, 'CD34 is required for infiltration of eosinophils into the colon and pathology associated with DSS-induced ulcerative colitis', American Journal of Pathology, 177 1244-1254 (2010) [C1]
DOI10.2353/ajpath.2010.100191
CitationsScopus - 13Web of Science - 12
2010Blanchet M-R, Gold M, Maltby SJ, Bennett J, Petri B, Kubes P, et al., 'Loss of CD34 leads to exacerbated autoimmune arthritis through increased vascular permeability', Journal of Immunology, 184 1292-1299 (2010) [C1]
DOI10.4049/?jimmunol.0900808
CitationsScopus - 13Web of Science - 15
2010Maltby SJ, Wong J, Berberovic Z, Birkenmeier CS, Haddon DJ, Garcha K, et al., 'A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe, hemolytic hereditary spherocytosis', Experimental Hematology, 39 601-610 (2010) [C1]
DOI10.1016/j.exphem.2010.12.009
CitationsScopus - 12Web of Science - 9
2009Maltby SJ, Hughes MR, Zbytnuik L, Paulson RF, McNagny KM, 'Podocalyxin selectively marks erythroid-committed progenitors during anemic stress but is dispensable for efficient recovery', Experimental Hematology, 37 10-18 (2009) [C1]
DOI10.1016/j.exphem.2008.09.006
CitationsScopus - 4Web of Science - 4
2007Blanchet M-R, Maltby SJ, Haddon DJ, Merkens H, Zbytnuik L, McNagny KM, 'CD34 facilitates the development of allergic asthma', Blood, 110 2005-2012 (2007) [C1]
CitationsScopus - 37Web of Science - 37
Show 8 more journal articles

Review (3 outputs)

YearCitationAltmetricsLink
2013Plank M, Maltby S, Mattes J, Foster PS, 'Targeting translational control as a novel way to treat inflammatory disease: The emerging role of MicroRNAs', Clinical and Experimental Allergy (2013) [C1]

Chronic inflammatory diseases (e.g. asthma and chronic obstructive pulmonary disease) are leading causes of morbidity and mortality world-wide and effective treatments are limited... [more]

Chronic inflammatory diseases (e.g. asthma and chronic obstructive pulmonary disease) are leading causes of morbidity and mortality world-wide and effective treatments are limited. These disorders can often be attributed to abnormal immune responses to environmental stimuli and infections. Mechanisms leading to inflammation are complex, resulting from interactions of structural cells and activation of both the adaptive and innate arms of the immune system. The activation of structural and immune cells involves both temporary and permanent changes in gene expression in these cells, which underpin chronic inflammation and tissue dysfunction. miRNAs are small non-coding RNAs increasingly being recognized to play important roles in the post-transcriptional regulation of gene expression in mammalian cells by regulating translation. Individual miRNAs can exert their effects by directly inhibiting the translation or stability of multiple mRNAs simultaneously. Thus, the expression or blockade of function of a single miRNA (miR) can result in pronounced alterations in protein expression within a given cell. Dysregulation of miRNA expression may subsequently alter cellular function, and in certain situations predispose to disease. Our current understanding of the role of miRNA in the regulation of inflammatory disease (e.g. allergic diseases) remains limited. In this review, we provide an overview of the current understanding of miRNA biogenesis and function, the roles miRNA play in the regulation of immune cell function and their potential contribution to inflammatory diseases. We also highlight strategies to alter miRNA function for experimental or therapeutic gain, and discuss the potential utility and limitations of targeting these molecules as anti-inflammatory strategies. © 2013 John Wiley & Sons Ltd.

DOI10.1111/cea.12135
CitationsScopus - 6Web of Science - 5
Co-authorsPaul Foster, Joerg Mattes
2013Plank M, Maltby S, Mattes J, Foster PS, 'Targeting translational control as a novel way to treat inflammatory disease: the emerging role of microRNAs.', Clinical and Experimental Allergy (2013) [C1]
DOI10.1111/cea.12170Author URL
Co-authorsPaul Foster, Joerg Mattes
2009Maltby SJ, Khash K, McNagny KM, 'Mast cells in tumor growth: angiogenesis, tissue remodeling and immune-modulation', Biochimica et biophysica acta - Reviews on Cancer (2009) [D1]
CitationsScopus - 113Web of Science - 100

Conference (7 outputs)

YearCitationAltmetricsLink
2015Tay H, Kaiko G, Plank M, Li J, Essilfie A, Maltby S, et al., 'THE ROLE OF MIR-328 IN RESPIRATORY DISEASES', RESPIROLOGY (2015)
Author URL
Co-authorsPhilip Hansbro
2014Mateer S, Maltby S, Marks E, Goggins B, Horvat J, Hansbro P, Keely S, 'Immune cell mis-homing drives secondary organ inflammation in inflammatory bowel disease; a focus on the respiratory system', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Author URL
Co-authorsPhilip Hansbro, Simon Keely, Jay Horvat
2012McNagny K, Debruin E, Gold M, Bennett J, Blanchet M-R, Maltby S, Hughes M, 'CD34 family proteins are key regulators of inflammatory cell migration and vascular integrity', JOURNAL OF IMMUNOLOGY, Boston, MA (2012) [E3]
Author URL
2011Maltby S, Gold M, Wohlfarth C, Blanchet M, McNagny KM, 'CD34 LOCALIZATION IN EOSINOPHILS AT STEADY STATE AND DURING DISEASE', EXPERIMENTAL HEMATOLOGY (2011) [E3]
Author URL
2008Blanchet M-R, Maltby S, Bennett J, McNagny K, 'Mouse models to study the role of CD34 in allergy and inflammatory diseases', FASEB JOURNAL (2008) [E3]
Author URL
2007Hughes MR, Anderson N, Maltby S, Wong J, Milenkovic Z, Wang C, et al., 'A new model of hereditary spherocytosis demonstrates profound homeostatic compensation in severely anemic mice.', BLOOD, Atlanta, GA (2007)
Author URL
2007Hughes MR, Maltby S, Zbytnuik L, Paulson R, McNagny KM, 'Podocalyxin is a selective marker of erythroid progenitors but is dispensable for anemia recovery.', BLOOD, Atlanta, GA (2007)
Author URL
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Grants and Funding

Summary

Number of grants8
Total funding$562,334

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $1,500

Keystone Symposium: Hematopoiesis, Colorado USA, 22-27 February 2015$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Steven Maltby
SchemeTravel Grant
RoleLead
Funding Start2015
Funding Finish2015
GNoG1500324
Type Of FundingInternal
CategoryINTE
UONY

20142 grants / $20,650

Virus Infections Change the Bone Marrow: Effects on Immunity, Bone Development and Inflammatory Disease$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Steven Maltby, Mr Max Plank, Doctor Hock Tay, Laureate Professor Paul Foster
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1401394
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Inaugural Future of Experimental Medicine Conference: Inflammation in Disease and Ageing, Sydney Australia, 16-19 March 2014$650

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Steven Maltby
SchemeTravel Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1400166
Type Of FundingInternal
CategoryINTE
UONY

20132 grants / $21,500

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Associate Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Doctor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
SchemeEquipment Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1201186
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

43rd Annual Scientific meeting of the Australasian Society for Immunology (ASI), Wellington New Zealand, 2 - 5 December 2013$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Steven Maltby
SchemeTravel Grant
RoleLead
Funding Start2013
Funding Finish2014
GNoG1300439
Type Of FundingInternal
CategoryINTE
UONY

20123 grants / $518,684

2011 Research Fellowship - DVCR Strategic Appointment (PRCARD)$348,315

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Steven Maltby
SchemeResearch Fellowship
RoleLead
Funding Start2012
Funding Finish2012
GNoG1100534
Type Of FundingInternal
CategoryINTE
UONY

Post-Doctoral Research Fellowship$150,000

Funding body: Canadian Institutes of Health Research (CIHR)

Funding bodyCanadian Institutes of Health Research (CIHR)
Project Team
SchemeHealth Research
RoleLead
Funding Start2012
Funding Finish2015
GNo
Type Of FundingInternational - Competitive
Category3IFA
UONN

Fellowship Start-up Grant$20,369

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Steven Maltby
SchemeFellowship Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200114
Type Of FundingInternal
CategoryINTE
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2012Roles of Bromodomain and extra terminal (BET) proteins in Suppression of Airway Inflammation
Microbiology, Faculty of Health and Medicine
Co-Supervisor
2012Understanding the mechanisms of airway hyper-responsiveness in a mouse model of asthma
Microbiology, Faculty of Health and Medicine
Co-Supervisor
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Dr Steven Maltby

Position

Postdoctoral Research Fellow
FOSTER GROUP
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Contact Details

Emailsteven.maltby@newcastle.edu.au
Phone(02) 404 20173
Fax(02) 404 20025

Office

RoomHMRI 2 East
BuildingHMRI
LocationNEWCASTLE

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