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Career Summary

Qualifications

  • PhD (Biochemistry and Molecular Genetics), University of New South Wales, 31/12/1997
  • Bachelor of Science (Honours), University of New South Wales, 31/12/1991

Research

Research keywords

  • Bioinformatics
  • Epigenetics
  • Genetics
  • Genomics
  • Neural development
  • Regulation of gene expression
  • Schizophrenia
  • Synaptic plasticity
  • Systems biology
  • microRNA
  • non-coding RNA

Research expertise

Molecular and cellular biology. High throughput genomics, bioinformatics and systems biology. Biology of non-coding RNA and post transcriptional gene regulation.

Expertise in these areas was developed to investigate mechanisms for gene regulation in neurodevelopment and their role in complex neuropsychiatric disorders.

Languages

  • English

Fields of Research

CodeDescriptionPercentage
110900Neurosciences40
060100Biochemistry And Cell Biology30
060400Genetics30

Teaching

Teaching expertise

Expertise in teaching biochemistry and molecular genetics.

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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
1999Cairns MJ, Hopkins TM, Witherington C, Wang L, Sun LQ, 'Target site selection for an RNA-cleaving catalytic DNA.', Nature biotechnology, 17 480-486 (1999)
2008Beveridge NJ, Tooney PA, Carroll AP, Gardiner EJ, Bowden NA, Scott R, et al., 'Dysregulation of miRNA 181b in the temporal cortex in schizophrenia', Human Molecular Genetics, 17 1156-1168 (2008) [C1]
2011Santarelli DMF, Beveridge NJ, Tooney PA, Cairns MJ, 'Upregulation of dicer and MicroRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia', Biological Psychiatry, 69 180-187 (2011) [C1]
2010Beveridge NJ, Gardiner EJ, Carroll AP, Tooney PA, Cairns MJ, 'Schizophrenia is associated with an increase in cortical microRNA biogenesis', Molecular Psychiatry, 15 1176-1189 (2010) [C1]
2012Gardiner EJ, Beveridge NJ, Wu JQ, Carr VJ, Scott R, Tooney PA, Cairns MJ, 'Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells', Molecular Psychiatry, 17 827-840 (2012) [C1]
2013Wang X, Cairns MJ, 'Gene set enrichment analysis of RNA-Seq data: integrating differential expression and splicing', BMC BIOINFORMATICS, 14 (2013) [C1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Chapter (5 outputs)

YearCitationAltmetricsLink
2013Liu B, Liu L, Tsykin A, Goodall GJ, Cairns MJ, Li J, 'Discovering Functional microRNA-mRNA Regulatory Modules in Heterogeneous Data', MicroRNA Cancer Regulation, Springer, Amsterdam 267-290 (2013) [B1]
2007Carroll AP, Wong JP, Cairns MJ, 'Designs and antiviral activity of gene-based drugs', Communicating Current Research and Educational Topics and Trends in Applied Microbiology, Formatex, Badajoz, Spain 902-914 (2007) [B1]
2007Cairns MJ, 'Combating the Threat of Pandemic Influenza', 126-147 (2007) [B1]
2004Cairns MJ, Sun L-Q, 'Target site selection for the 10-23 DNAzyme', Ribozymes and siRNA protocols, Humana Press, Totowa, New Jersey, USA 267-277 (2004) [B1]
2004Cairns MJ, Sun L-Q, 'Nucleic acid sequence analysis using DNAzymes', Ribozymes and siRNA protocol, Humana Press, Totowa, New York, USA 291-302 (2004) [B1]
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Journal article (67 outputs)

YearCitationAltmetricsLink
2014Goldie BJ, Dun MD, Lin M, Smith ND, Verrills NM, Dayas CV, Cairns MJ, 'Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons.', Nucleic Acids Research, 42 9195-9208 (2014) [C1]
2014Oldmeadow C, Mossman D, Evans TJ, Holliday EG, Tooney PA, Cairns MJ, et al., 'Combined analysis of exon splicing and genome wide polymorphism data predict schizophrenia risk loci.', J Psychiatr Res, 52 44-49 (2014) [C1]
2014McCarthy-Jones S, Green MJ, Scott RJ, Tooney PA, Cairns MJ, Wu JQ, et al., 'Preliminary evidence of an interaction between the FOXP2 gene and childhood emotional abuse predicting likelihood of auditory verbal hallucinations in schizophrenia', JOURNAL OF PSYCHIATRIC RESEARCH, 50 66-72 (2014) [C1]
2014Hollins SL, Goldie BJ, Carroll AP, Mason EA, Walker FR, Eyles DW, Cairns MJ, 'Ontogeny of small RNA in the regulation of mammalian brain development.', BMC Genomics, 15 777 (2014)
2014Walker FR, Beynon SB, Jones KA, Zhao Z, Kongsui R, Cairns M, Nilsson M, 'Dynamic structural remodelling of microglia in health and disease: a review of the models, the signals and the mechanisms.', Brain Behav Immun, 37 1-14 (2014)
2014Gupta P, Cairns MJ, Saksena NK, 'Regulation of gene expression by microRNA in HCV infection and HCV-mediated hepatocellular carcinoma', Virology Journal, 11 (2014)
2014Gupta P, Liu B, Wu JQ, Soriano V, Vispo E, Carroll AP, et al., 'Genome-wide mRNA and miRNA analysis of peripheral blood mononuclear cells (PBMC) reveals different miRNAs regulating HIV/HCV co-infection', Virology, 450-451 336-349 (2014)
2014Barry G, Briggs JA, Vanichkina DP, Poth EM, Beveridge NJ, Ratnu VS, et al., 'The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing', Molecular Psychiatry, 19 486-494 (2014)
2014Hollins SL, Zavitsanou K, Walker FR, Cairns MJ, 'Alteration of imprinted Dlk1-Dio3 miRNA cluster expression in the entorhinal cortex induced by maternal immune activation and adolescent cannabinoid exposure.', Transl Psychiatry, 4 e452 (2014)
2014Iseme RA, McEvoy M, Kelly B, Agnew L, Attia J, Walker FR, 'Autoantibodies and depression: evidence for a causal link?', Neurosci Biobehav Rev, 40 62-79 (2014)
2014Gardiner E, Carroll A, Tooney PA, Cairns MJ, 'Antipsychotic drug-associated gene-miRNA interaction in T-lymphocytes', International Journal of Neuropsychopharmacology, 17 929-943 (2014)
2014Wang X, Cairns MJ, 'SeqGSEA: a Bioconductor package for gene set enrichment analysis of RNA-Seq data integrating differential expression and splicing.', Bioinformatics, 30 1777-1779 (2014)
2014Green MJ, Chia T-Y, Cairns MJ, Wu J, Tooney PA, Scott RJ, Carr VJ, 'Catechol-O-methyltransferase (COMT) genotype moderates the effects of childhood trauma on cognition and symptoms in schizophrenia', JOURNAL OF PSYCHIATRIC RESEARCH, 49 43-50 (2014)
2014Liu B, Li J, Cairns MJ, 'Identifying miRNAs, targets and functions', Briefings in Bioinformatics, 15 1-19 (2014)
2014Wang X, Cairns MJ, 'Understanding complex transcriptome dynamics in schizophrenia and other neurological diseases using RNA sequencing', International Review of Neurobiology, 116 127-152 (2014)
2013Santarelli DM, Liu B, Duncan CE, Beveridge NJ, Tooney PA, Schofield PR, Cairns MJ, 'Gene-microRNA interactions associated with antipsychotic mechanisms and the metabolic side effects of olanzapine', PSYCHOPHARMACOLOGY, 227 67-78 (2013) [C1]
2013Green MJ, Cairns MJ, Wu J, Dragovic M, Jablensky A, Tooney PA, et al., 'Genome-wide supported variant MIR137 and severe negative symptoms predict membership of an impaired cognitive subtype of schizophrenia', MOLECULAR PSYCHIATRY, 18 774-780 (2013) [C1]
2013Wong J, Duncan CE, Beveridge NJ, Webster MJ, Cairns MJ, Weickert CS, 'Expression of NPAS3 in the Human Cortex and Evidence of Its Posttranscriptional Regulation by miR-17 During Development, With Implications for Schizophrenia', SCHIZOPHRENIA BULLETIN, 39 396-406 (2013) [C1]
2013Scarr E, Craig JM, Cairns MJ, Seo MS, Galati JC, Beveridge NJ, et al., 'Decreased cortical muscarinic M1 receptors in schizophrenia are associated with changes in gene promoter methylation, mRNA and gene targeting microRNA', TRANSLATIONAL PSYCHIATRY, 3 (2013) [C1]
2013Carroll AP, Tooney PA, Cairns MJ, 'Context-specific microRNA function in developmental complexity', Journal of Molecular Cell Biology, 5 73-84 (2013) [C1]
2013Wang X, Cairns MJ, 'Gene set enrichment analysis of RNA-Seq data: integrating differential expression and splicing', BMC BIOINFORMATICS, 14 (2013) [C1]
2013Carroll AP, Tooney PA, Cairns MJ, 'Design and interpretation of microRNA-reporter gene activity', Analytical Biochemistry, 437 164-171 (2013) [C1]
2013Gardiner EJ, Cairns MJ, Liu B, Beveridge NJ, Carr V, Kelly B, et al., 'Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells', JOURNAL OF PSYCHIATRIC RESEARCH, 47 425-437 (2013) [C1]
2013Fillman SG, Cloonan N, Catts VS, Miller LC, Wong J, McCrossin T, et al., 'Increased inflammatory markers identified in the dorsolateral prefrontal cortex of individuals with schizophrenia', MOLECULAR PSYCHIATRY, 18 206-214 (2013) [C1]
2013Cairns MJ, Kocerha J, 'Advances in non-coding RNA profiling for neurological diseases', Frontiers in Genetics, 4 (2013) [C3]
2013Barry G, Vanichkina DP, Taft RJ, Briggs JA, Nayler SP, Wolvetang EJ, et al., 'The long non-coding RNA Gomafu is acutely regulated in response to neuronal activation and involved in schizophrenia-associated alternative splicing', Molecular Psychiatry, (2013)
2012Beveridge NJ, Cairns MJ, 'MicroRNA dysregulation in schizophrenia', Neurobiology of Disease, 46 263-271 (2012) [C1]
2012Goldie BJ, Cairns MJ, 'Post-transcriptional trafficking and regulation of neuronal gene expression', Molecular Neurobiology, 45 99-108 (2012) [C1]
2012Gardiner EJ, Beveridge NJ, Wu JQ, Carr VJ, Scott R, Tooney PA, Cairns MJ, 'Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells', Molecular Psychiatry, 17 827-840 (2012) [C1]
2012Kim K-T, Carroll AP, Mashkani B, Cairns MJ, Small D, Scott R, 'MicroRNA-16 Is down-regulated in mutated FLT3 expressing murine myeloid FDC-P1 cells and interacts with Pim-1', PLOS One, 7 e44546 (2012) [C1]

Co-authors: Rodney Scott

2012Tynan R, Weidenhofer JC, Hinwood M, Cairns MJ, Day TA, Walker FR, 'A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia', Brain Behavior and Immunity, 26 469-479 (2012) [C1]
2012Wu JQ, Wang X, Beveridge NJ, Tooney PA, Scott R, Carr VJ, Cairns MJ, 'Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia', PLoS One, 7 e36351 (2012) [C1]
2012Carroll AP, Tran N, Tooney PA, Cairns MJ, 'Alternative mRNA fates identified in microRNA-associated transcriptome analysis', BMC Genomics, 13 1-19 (2012) [C1]

Co-authors: Paul Tooney

2012Zhou L, Pupo GM, Gupta P, Liu B, Tran SL, Rahme R, et al., 'A parallel genome-wide mRNA and microRNA profiling of the frontal cortex of HIV patients with and without HIV-associated dementia shows the role of axon guidance and downstream pathways in HIV-mediated neurodegeneration', BMC Genomics, 13 677 (2012) [C1]
2011Santarelli DMF, Beveridge NJ, Tooney PA, Cairns MJ, 'Upregulation of dicer and MicroRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia', Biological Psychiatry, 69 180-187 (2011) [C1]
2010Cox MB, Cairns MJ, Gandhi KS, Carroll AP, Moscovis CC, Stewart GJ, et al., 'MicroRNAs miR-17 and miR-20a inhibit T cell activation genes and are under-expressed in MS whole blood', Plos One, 5 e12132 (2010) [C1]
2010Saravolac EG, Wong JP, Cairns MJ, 'Recent patents in antiviral siRNAs', Recent Patents on Anti-Infective Drug Discovery, 5 44-57 (2010) [C1]
2010Beveridge NJ, Gardiner EJ, Carroll AP, Tooney PA, Cairns MJ, 'Schizophrenia is associated with an increase in cortical microRNA biogenesis', Molecular Psychiatry, 15 1176-1189 (2010) [C1]
2010Wong JP, Christopher ME, Salazar AM, Sun L-Q, Viswanathan S, Wang M, et al., 'Broad-spectrum and virus-specific nucleic acid-based antivirals against influenza', Frontiers in Bioscience, 1 791-800 (2010) [C1]
2010Carland M, Grannas MJ, Cairns MJ, Roknic V, Denny WA, McFadyen WD, Murray V, 'Substituted 9-aminoacridine-4-carboxamides tethered to platinum(II)diamine complexes: Chemistry, cytotoxicity and DNA sequence selectivity', Journal of Inorganic Biochemistry, 104 815-819 (2010) [C1]
2009Lai A, Cairns MJ, Tran N, Zhang H-P, Cullen L, Arndt GM, 'RNA modulators of complex phenotypes in mammalian cells', PLoS ONE, 4 e4758 (2009) [C1]
2009Beveridge NJ, Tooney PA, Carroll AP, Tran N, Cairns MJ, 'Down-regulation of miR-17 family expression in response to retinoic acid induced neuronal differentiation', Cellular Signalling, 21 1837-1845 (2009) [C1]
2009Zhang X, Cairns MJ, Rose B, O'Brien C, Shannon K, Clark J, et al., 'Alterations in miRNA processing and expression in pleomorphic adenomas of the salivary gland', International Journal of Cancer, 124 2855-2863 (2009) [C1]
2009Cairns MJ, Thomas T, Beltran CE, Tillett D, 'Primer fabrication using polymerase mediated oligonucleotide synthesis', BMC Genomics, 10 1-10 (2009) [C1]
2009Cairns MJ, Carland M, David Mcfadyen W, Denny WA, Murray V, 'The DNA sequence selectivity of maltolato-containing cisplatin analogues in purified plasmid DNA and in intact human cells', Journal of Inorganic Biochemistry, 103 1151-1155 (2009) [C1]
2008Beveridge NJ, Tooney PA, Carroll AP, Gardiner EJ, Bowden NA, Scott R, et al., 'Dysregulation of miRNA 181b in the temporal cortex in schizophrenia', Human Molecular Genetics, 17 1156-1168 (2008) [C1]
2008Cairns MJ, 'Small interfering RNAs and their therapeutic applications in mitigation of virus replication and pathological effects in the respiratory tract', Anti-Inflammatory and Anti-Allergy Agents in Medicinal Chemistry, 7 116-121 (2008) [C1]
2007Bhindi R, Fahmy RG, Lowe HC, Chesterman CN, Dass CR, Cairns MJ, et al., 'Brothers in arms: DNA enzymes, short interfering RNA, and the emerging wave of small-molecule nucleic acid-based gene-silencing strategies', American Journal of Pathology, 171 1079-1088 (2007) [C1]
2007Wong JP, Christopher ME, Cairns M, Sun L, Dale RMK, Salazar AM, 'Current Status on Development of Nucleic Acid-Based Antiviral Drugs Against Influenza Virus Infection 126-147 (2007)
2004Cairns MJ, Turner R, Sun L-Q, 'Homogeneous real-time detection and quantification of nucleic acid amplification using restriction enzyme digestion', Biochemical and Biophysical Research Communications, 318 684-690 (2004) [C1]
2003Kim Y, Cairns MJ, Marouga R, Sun L-Q, 'E6AP gene suppression and characterization with in vitro selected hammerhead ribozymes', Cancer Gene Therapy, 10 707-716 (2003) [C1]
2003Tran N, Cairns MJ, Dawes IW, Arndt GM, 'Expressing functional siRNAs in mammalian cells using convergent transcription', BMC Biotechnology, 3 0-0 (2003) [C1]
2003Cairns MJ, King A, Sun L-Q, 'Optimisation of the 10±23 DNAzyme±substrate pairing interactions enhanced RNA cleavage activity at purine±cytosine target sites', Nucleic Acids Research, 31 2883-2889 (2003) [C1]
2002Cairns MJ, Saravolac EG, Sun LQ, 'Catalytic DNA: A novel tool for gene suppression', Current Drug Targets, 3 269-279 (2002)
2000Cairns MJ, Hopkins TM, Witherington C, Sun L-Q, 'The influence of arm length asymmetry and base substitution on the activity of the 10-23 DNA enzyme', Antisense and Nucleic Acid Drug Development, 10 323-332 (2000)
2000Sun L-Q, Cairns MJ, Saravolac EG, Baker A, Gerlach WL, 'Catalytic nucleic acids: From lab to applications', Pharmacological Reviews, 52 325-347 (2000)
2000Cairns MJ, King A, Sun LQ, 'Nucleic acid mutation analysis using catalytic DNA.', Nucleic acids research, 28 (2000)
1999Cairns MJ, Hopkins TM, Witherington C, Wang L, Sun LQ, 'Target site selection for an RNA-cleaving catalytic DNA.', Nature biotechnology, 17 480-486 (1999)
1999Sun LQ, Cairns MJ, Gerlach WL, Witherington C, Wang L, King A, 'Suppression of smooth muscle cell proliferation by a c-myc RNA-cleaving deoxyribozyme.', The Journal of biological chemistry, 274 17236-17241 (1999)
1999Temple MD, Cairns MJ, Kim A, Murray V, 'Protein-DNA footprinting of the human e-globin promoter in human intact cells using nitrogen mustard analogues and other DNA-damaging agents', Biochimica et Biophysica Acta - Gene Structure and Expression, 1445 245-256 (1999)
1998Cairns MJ, Murray V, 'The DNA sequence specificity of hedamycin damage determined by ligation-mediated PCR and linear amplification', Biochemistry and Molecular Biology International, 46 267-275 (1998)
1998Cairns MJ, 'Detection of protein-DNA interactions at ß-globin gene cluster in intact human cells utilizing hedamycin as DNA-damaging agent', DNA and Cell Biology, 17 325-333 (1998)
1997Temple MD, Cairns MJ, Denny WA, Murray V, 'Protein-DNA interactions in the human ß-globin locus control region hypersensitive site-2 as revealed by four nitrogen mustards', Nucleic Acids Research, 25 3255-3260 (1997)
1996Cairns MJ, Murray V, 'Influence of chromatin structure on bleomycin-DNA interactions at base pair resolution in the human ß-globin gene cluster', Biochemistry, 35 8753-8760 (1996)
1994Cairns MJ, Murray V, 'Dideoxy genomic sequencing of a single-copy mammalian gene using more than two hundred cycles of linear amplification', BioTechniques, 17 910-913+914 (1994)
1994Cairns MJ, Murray V, 'Comparison of the sequence specificity of cis-diamminedichloroplatinum (II) damage in guanine- and 7-deazaguanine-containing DNA', Biochimica et Biophysica Acta - Gene Structure and Expression, 1218 315-321 (1994)
1993Murray V, Monchawin C, Cairns MJ, England PR, Leigh D, McDonald BL, 'Detection of polymorphisms using thermal cycling with a single oligonucleotide on a DNA sequencing gel', Human Mutation, 2 118-122 (1993)
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Conference (45 outputs)

YearCitationAltmetricsLink
2013Bond D, Cairns M, Ashman L, Weidenhofer J, 'Post-transcriptional regulation of CD151 & CD9 by miRNAs in prostate cancer', BJU INTERNATIONAL (2013) [E3]
2012Carroll AP, Tooney PA, Cairns MJ, 'Biological investigation of schizophrenia-associated miRNA dysregulation', Abstract Book. Biological Psychiatry Australia Scientific Meeting, Parkville, Vic (2012) [E3]

Co-authors: Paul Tooney

2012Cairns MJ, Santarelli DMF, Carroll AP, Beveridge NJ, Hollins SL, Goldie BJ, Gardiner EJ, 'miRNA: There importance for brain function and neuropsychiatry', Abstract Book. Biological Psychiatry Australia Scientific Meeting, Parkville, Vic (2012) [E3]
2012Goldie BJ, Cairns MJ, 'Integration of subcellular miRNA and mRNA responses to differentiation and depolarisation in neuronal cells', Gene Silencing by Small RNAs. Keystone Symposia on Molecular and Cellular Biology, Vancouver, Canada (2012) [E3]
2012Bond DR, Cairns MJ, Ashman LK, Weidenhofer JC, 'Investigating micro-RNA regulation of tetraspanins CD151 and CD9 in prostate cancer', Febs Journal, Seville, Spain (2012) [E3]
2012Dayas CV, Quinn RK, Goldie BJ, Brown AM, Levi EM, Smith DW, Cairns MJ, 'Association of miRNAs with addiction-relevant synaptic plasticity genes', Abstract Book. Biological Psychiatry Australia Scientific Meeting, Parkville, Vic (2012) [E3]
2012Goldie BJ, Cairns MJ, 'mRNA-miRNA responses to depolarization in neuronal cells', 45th Annual Winter Conference on Brain Research, Snowbird, Utah (2012) [E3]
2012Cairns MJ, 'Genetic and epigenetic regulation of schizophrenia associated microrna', Presentation Abstracts. XXth World Congress of Psychiatric Genetics, Hamburg, Germany (2012) [E3]
2012Cairns MJ, 'MicroRNA in schizophrenia and developmental disorders', European Neuropsychopharmacology, Vienna, Austria (2012) [E3]
2012Gardiner EJ, Cairns MJ, Beveridge NJ, Liu B, Mossman D, Carr VJ, et al., 'Differential gene expression in peripheral blood mononuclear cells from a large cohort of participants with schizophrenia', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
2012Hollins SL, Goldie BJ, Carroll AP, Mason EA, Cairns MJ, Eyles D, 'Dynamic changes in microRNA expression during mammalian brain development coincides with forebrain maturation', Abstract Book. Biological Psychiatry Australia Scientific Meeting, Parkville, Vic (2012) [E3]
2011Milward AE, Hollins SL, Graham R, Trinder D, Van Balen M, Olynyk J, et al., 'Iron and the biogenesis of melanin and melanosomes in the retina', Program Book: Fourth Congress of the International BioIron Society (IBIS), Vancouver, Canada (2011) [E3]

Co-authors: Liz Milward

2011Cairns MJ, Beveridge NJ, Schaefer A, Kenny P, 'MicroRNA in brain development, function, and pathology', Forty-Fourth Annual Winter Conference on Brain Research, Keystone, Colorado (2011) [E3]
2011Cairns MJ, 'Repression of maternally expressed microRNA clustered on 14q32 is associated with schizophrenia', 75th Anniversary Scientific Symposium: Research for a Healthy Future. Symposium Handbook, Canberra, ACT (2011) [E3]
2011Acikyol B, Johnstone DM, Trinder D, Cairns MJ, Milward AE, 'Gene expression changes relating to key brain functions and neuropsychiatric disorders in the TFR2 mutant mouse', Program Book: Fourth Congress of the International BioIron Society (IBIS), Vancouver, Canada (2011) [E3]
2011Hollins SL, Mason EA, Cairns MJ, Eyles D, 'Genome-wide analysis of microRNA and gene expression in the developing rat brain', The Proceedings of the First Scientific Meeting of Biological Psychiatry Australia, Melbourne, VIC (2011) [E3]
2011Cairns MJ, Wu JQ, Tooney PA, Wang X, 'RNA-seq reveals significant alteration of cortical promoter usage and splicing in schizophrenia', The Proceedings of the First Scientific Meeting of Biological Psychiatry Australia, Melbourne, VIC (2011) [E3]

Co-authors: Paul Tooney

2011Beveridge NJ, Santarelli DMF, Tooney PA, Webster MJ, Weickert CS, Cairns MJ, 'Maturation of the human dorsolateral prefrontal cortex coincides with a dynamic shift in microRNA expression', The Proceedings of the First Scientific Meeting of Biological Psychiatry Australia, Melbourne, VIC (2011) [E3]

Co-authors: Paul Tooney

2011Mossman D, Tooney PA, Cairns MJ, Kelly BJ, Carr V, Scott R, 'Identification of alternatively spliced gene variants in schizophrenia', Schizophrenia Bulletin, Colorado Springs, CO (2011) [E3]
2011Mason EA, McGrath JJ, Cairns MJ, Eyles D, 'In silico mirna candidates regulating dopaminergic neuron development', Posters. Australian Neuroscience Society 31st Annual Meeting, Auckland, New Zealand (2011) [E3]
2011Gupta P, Liu B, Wu JQ, Dyer WB, Dwyer DE, Wang B, et al., 'Parallel miRNA and mRNA profiling in HCV-infected peripheral blood cells (PBMC) and tumor/non-tumor liver tissue from patients with hepatocellular carcinoma (HCC) show correlation with cancer pathways', Global Antiviral Journal, Kauai, Hawaii (2011) [E3]
2011Gupta P, Liu B, Wu JQ, Soriano V, Rodes B, Dyer WB, et al., 'Genome-wide mRNA and miRNA profiling from HCV, HIV and HIV+HCV co-infected peripheral blood mononuclear cells (PBMC) reveal distinct micro-RNAs regulating HIV+HCV co-infection', Global Antiviral Journal, Kauai, Hawaii (2011) [E3]
2011Gardiner EJ, Beveridge NJ, Liu B, Carr VJ, Scott R, Tooney PA, Cairns MJ, 'Gene expression profiling in peripheral blood mononuclear cells in schizophrenia', The Proceedings of the First Scientific Meeting of Biological Psychiatry Australia, Melbourne, VIC (2011) [E3]
2011Saksena NK, Gupta P, Liu B, Wu JQ, Soriano V, Rodes B, et al., 'Human microRNA (hsa-miR-21): A novel marker for HIV+HCV co-infection', Global Antiviral Journal, Kauai, Hawaii (2011) [E3]
2011Wu J, Tooney PA, Wang X, Cairns MJ, 'Quantitative transcriptome sequencing reveals altered presynaptic vesicle trafficking and myelination in the temporal cortex in schizophrenia', Presentation Abstracts: XIXth World Congress of Psychiatric Genetics, Washington, DC (2011) [E3]

Co-authors: Paul Tooney

2011Sams M, Beveridge NJ, Newburn E, Cairns MJ, Hyde T, Kleinman J, Lipska B, 'MicroRNA expression in the prefrontal cortex during the human lifespan', Forty-Fourth Annual Winter Conference on Brain Research, Keystone, Colorado (2011) [E3]
2010Beveridge NJ, Tooney PA, Webster M, Weickert CS, Cairns MJ, 'Microrna expression throughout postnatal development if the human dorsolateral prefrontal cortex', Australian & New Zealand Journal of Psychiatry, Sydney, Australia (2010) [E3]

Co-authors: Paul Tooney

2010Wu JQ, Cairns MJ, Scott R, Carr V, Mowry B, Jablensky A, et al., 'Genome wide analysis of DNA copy number in schizophrenia reveals loss of heterozygosity on chromosome 6P22.1 and 16P11.2-11.1', Australian & New Zealand Journal of Psychiatry, Sydney, Australia (2010) [E3]
2010Cairns MJ, Beveridge NJ, Scarr E, Dean B, 'Potential role for gene directed micrornas in the pathophysiology of muscarinic receptor deficit schizophrenia', Australian & New Zealand Journal of Psychiatry, Sydney, Australia (2010) [E3]
2010Santarelli DMF, Beveridge NJ, Tooney PA, Cairns MJ, 'Upregulation of dicer and microrna expression in the dorsolateral prefrontal cortex (Brodmann's Area 46) in schizophrenia', Australian & New Zealand Journal of Psychiatry, Sydney, Australia (2010) [E3]

Co-authors: Paul Tooney

2010Gardiner EJ, Beveridge NJ, Santarelli DMF, Wu JQ, Carr V, Scott R, et al., 'Mirna expression profiling in patients with schizophrenia', Australian & New Zealand Journal of Psychiatry, Sydney, NSW (2010) [E3]
2010Weickert CS, Duncan C, Beveridge NJ, Wong J, Webster MJ, Cairns MJ, 'Regulation of psychosis gene NPAS3 by microrna during postnatal development and in schizophrenia', Schizophrenia Research, Florence, Italy (2010) [E3]
2010Gardiner E, Beveridge NJ, Santarelli D, Wu J, Carr V, Scott RJ, et al., 'MIRNA EXPRESSION PROFILING IN PATIENTS WITH SCHIZOPHRENIA', AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY (2010) [E3]
2009Cairns MJ, Beveridge NJ, Carroll AP, Tooney PA, Gardiner EJ, Santarelli DMF, 'Alteration of microRNA biogenesis in schizophrenia and its implications for synaptic structure and function', Schizophrenia Bulletin, San Diego, CA (2009) [E3]
2009Beveridge NJ, Carroll AP, Tooney PA, Cairns MJ, 'MicroRNA changes in the prefrontal and temporal cortices in schizophrenia', Schizophrenia Bulletin, San Diego, CA (2009) [E3]
2009Cairns MJ, Beveridge NJ, Carroll AP, Gardiner EJ, Tooney PA, Santarelli DMF, 'Alteration of cortical microRNA biogenesis in schizophrenia and its influence on gene expression', XVIIth World Congress on Psychiatric Genetics: Abstract Book, San Diego, CA (2009) [E3]

Co-authors: Paul Tooney

2008Cairns MJ, 'MiRNA and post-transcriptional regulation in schizophrenia', XVIth World Congress on Psychiatric Genetics: Abstract, Osaka, Japan (2008) [E3]
2008Beveridge NJ, Tooney PA, Carroll AP, Cairns MJ, 'MicroRNA changes in the cerebral cortex in schizophrenia', Proceedings of the Australian Society for Biochemistry and Molecular Biology, Canberra, ACT (2008) [E3]

Co-authors: Paul Tooney

2008Beveridge NJ, Carroll AP, Gardiner EJ, Tooney PA, Cairns MJ, 'MicroRNA changes in the prefrontal and temporal cortices in schizophrenia', Australian and New Zealand Journal of Psychiatry, Newcastle, NSW (2008) [E3]

Co-authors: Paul Tooney

2008Gardiner EJ, Carroll AP, Beveridge NJ, Tooney PA, Cairns MJ, 'Investigation of miRNA influence on RGS4 and NRG1 gene expression in schizophrenia', Australian and New Zealand Journal of Psychiatry, Newcastle, NSW (2008) [E3]

Co-authors: Paul Tooney

2008Beveridge NJ, Carroll AP, Tooney PA, Cairns MJ, 'Dysregulation of miRNA 181b in the temporal cortex in schizophrenia', 2008 Lorne Genome Conference Delegate Handbook, Lorne, VIC (2008) [E3]

Co-authors: Paul Tooney

2008Carroll AP, Beveridge NJ, Gardiner EJ, Tooney PA, Cairns MJ, 'Identification of biologically relevant, schizophrenia-associated MicroRNA targets', Australian and New Zealand Journal of Psychiatry, Newcastle, NSW (2008) [E3]

Co-authors: Paul Tooney

2008Carroll AP, Beveridge NJ, Tooney PA, Cairns MJ, 'Identification of biologically relevant miRNA targets through the bidirectional modulation of miRNA expression', 2008 Lorne Genome Conference Delegate Handbook, Lorne, VIC (2008) [E3]

Co-authors: Paul Tooney

2007Tooney PA, Scott R, Cairns MJ, Bowden NA, 'Altered gene expression in the superior temporial gyrus in schizophrenia', Schizophrenia Bulletin (Abstracts of the 11th International Congress on Schizophrenia Research), Colorado Springs, Colorado (2007) [E3]
2007Cairns MJ, Beveridge NJ, Carroll A, Scott R, Tooney PA, 'Investigation of post transcriptional gene silencing in schizophrenia', Schizophrenia Bulletin (Abstracts of the 11th International Congress on Schizophrenia Research), Colorado Springs, Colorado (2007) [E3]
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Grants and Funding

Summary

Number of grants27
Total funding$4,850,492

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (2 grants)

Modelling schizophrenia-associated changes in mir-137 expression$567,044
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Associate Professor Murray Cairns, Doctor Frederick Walker
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$567,04420142017
GNo:G1300360

Genetic and Environmental Determinants of Depressive Symptoms: Trajectory and Outcomes in a Longitudinal Population Data Set$30,000
Funding Body: Hunter Medical Research Institute

Project Team
Professor Brian Kelly, Associate Professor Paul Tooney, Professor Rodney Scott, Professor John Attia, Conjoint Associate Professor Murray Cairns, Professor Vaughan Carr
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$30,00020142014
GNo:G1400594

2013 (6 grants)

Epistatic genetic effects on neuroanatomical subtypes of schizophrenia$194,894
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Dr Melissa Green, Conjoint Associate Professor Murray Cairns, Professor Kristin Laurens, Professor Vaughan Carr
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$194,89420132013
GNo:G1201211

Functional characterisation of schizophrenia-associated neurodevelopmental dysfunction of miR-137$25,000
Funding Body: Hunter Medical Research Institute

Project Team
Conjoint Associate Professor Murray Cairns, Doctor Frederick Walker, Associate Professor Alan Brichta, Ms Natalie Beveridge
SchemeRole
Near MissChief Investigator
Total AmountFunding StartFunding Finish
$25,00020132013
GNo:G1300801

Functional characterisation of schizophrenia-associated neurodevelopmental dysfunction of miR-137$25,000
Funding Body: University of Newcastle

Project Team
Conjoint Associate Professor Murray Cairns, Doctor Frederick Walker, Associate Professor Alan Brichta, Ms Natalie Beveridge
SchemeRole
Near Miss GrantChief Investigator
Total AmountFunding StartFunding Finish
$25,00020132013
GNo:G1300468

Ultra-Low Temperature Cryogenic Freezer$24,596
Funding Body: NHMRC (National Health & Medical Research Council)

microRNA and translation dynamics of synaptic plasticity$20,000
Funding Body: University of Newcastle

Project Team
Conjoint Associate Professor Murray Cairns, Associate Professor Alan Brichta, Doctor Frederick Walker
SchemeRole
Near Miss GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020132013
GNo:G1300463

International Congress on Schizophrenia Research, Florida 19-26 April 2013.$2,000
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Conjoint Associate Professor Murray Cairns
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,00020132013
GNo:G1300787

2012 (3 grants)

In Vivo Analysis Of The Molecular And Neural Mechanism That Underly An Association Of miRNAs With Mental Disorders$225,360
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Thomas Becker, Dr Silke Rinkwitz, Conjoint Associate Professor Murray Cairns
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$225,36020122014
GNo:G1200009

Microscopic illumination system for advanced fluorescent protein technology$34,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Rick Thorne, Professor Xu Dong Zhang, Conjoint Associate Professor Murray Cairns, Doctor Nikki Verrills, Doctor Charles De Bock, Doctor Jude Weidenhofer, Doctor Severine Roselli, Doctor Kathryn Skelding, Emeritus Professor Leonie Ashman, Professor Hubert Hondermarck
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$34,00020122012
GNo:G1100983

Roles of post-transcriptional gene silencing in the functional regulation of neuronal gene expression and plasticity in schizophrenia$19,500
Funding Body: Schizophrenia Research Institute

Project Team
Conjoint Associate Professor Murray Cairns, Ms Belinda Goldie, Doctor Chris Dayas
SchemeRole
Postgraduate Research ScholarshipChief Investigator
Total AmountFunding StartFunding Finish
$19,50020122014
GNo:G1200761

2011 (3 grants)

The potential of non-coding RNAs in saliva and urine as prostate cancer biomarkers$447,000
Funding Body: US Department of Defense

SchemeRole
Army Medical Research and Materiel Command Congressionally Directed Medical Research Programs Investigator
Total AmountFunding StartFunding Finish
$447,00020112013
GNo:182908275

Emerging Research Leaders Program 2011$15,000
Funding Body: University of Newcastle

Project Team
Conjoint Associate Professor Murray Cairns
SchemeRole
Emerging Research Leaders ProgramChief Investigator
Total AmountFunding StartFunding Finish
$15,00020112011
GNo:G1101039

IMPLEN NanoPhotometer pearl$10,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Associate Professor Alan Brichta, Emeritus Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Professor Ulli Schall, Associate Professor Phillip Dickson, Doctor Frederick Walker, Doctor Rick Thorne, Doctor Chris Dayas, Doctor Nikki Verrills, Doctor Janet Holt, Doctor Severine Roselli, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Associate Professor Liz Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Mr Dan Johnstone, Ms Belinda Goldie, Ms Natalie Beveridge
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00020112011
GNo:G1100030

2010 (4 grants)

Molecular and cellular characterisation of schizophrenia associated dysfunction in microRNA biogenesis$478,500
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Associate Professor Murray Cairns, Professor Rodney Scott, Associate Professor Paul Tooney, Emeritus Professor John Rostas, Associate Professor Alan Brichta
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$478,50020102012
GNo:G0190196

NARSAD Young Investigators Award - Neurodevelopmental model of schizophrenia-associated changes in gene silencing.$76,916
Funding Body: Brain & Behavior Research Foundation

Project Team
Conjoint Associate Professor Murray Cairns
SchemeRole
NARSAD Young Investigator GrantChief Investigator
Total AmountFunding StartFunding Finish
$76,91620102011
GNo:G0189432

ABI 7500 Real Time PCR System $34,000
Funding Body: NHMRC (National Health & Medical Research Council)

Analysis of schizophrenia-associated gene and mircoRNA signatures in purified CD4 and CD8 positive T-cells$25,000
Funding Body: Hunter Children`s Research Foundation

Project Team
Conjoint Associate Professor Murray Cairns, Doctor Jing Qin Wu, Associate Professor Paul Tooney, Professor Rodney Scott
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$25,00020102010
GNo:G0900188

2009 (1 grants)

Investigation of schizophrenia associated gene and miRNA expression in the dorsolateral prefrontal cortex$19,719
Funding Body: Schizophrenia Research Institute

Project Team
Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney
SchemeRole
Postgraduate Research ScholarshipChief Investigator
Total AmountFunding StartFunding Finish
$19,71920092011
GNo:G0190436

2008 (3 grants)

Neuro-behavioural genetics network research program$2,400,000
Funding Body: NSW Ministry of Health

Project Team
Conjoint Professor Vaughan Carr, Professor Rodney Scott, Associate Professor Paul Tooney, Professor Brian Kelly, Conjoint Associate Professor Murray Cairns
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$2,400,00020082010
GNo:G0189170

A road map of schizophrenia associated with gene and miRNA expression in the dorsolateral prefrontal cortex$25,000
Funding Body: Hunter Medical Research Institute

Project Team
Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$25,00020082008
GNo:G0188461

Investigation of miRNA influence on NRG1 dysregulation in schizophrenia$16,000
Funding Body: Schizophrenia Research Institute

Project Team
Associate Professor Paul Tooney, Conjoint Associate Professor Murray Cairns
SchemeRole
Postgraduate Research ScholarshipInvestigator
Total AmountFunding StartFunding Finish
$16,00020082011
GNo:G0188594

2007 (4 grants)

Post Transcriptional Gene Silencing in Schizophrenia$59,761
Funding Body: Brain & Behavior Research Foundation

Project Team
Conjoint Associate Professor Murray Cairns
SchemeRole
NARSAD Young Investigator GrantChief Investigator
Total AmountFunding StartFunding Finish
$59,76120072009
GNo:G0186852

Gene silencing in the pathogenesis of schizophrenia$23,750
Funding Body: Schizophrenia Research Institute

Project Team
Associate Professor Paul Tooney, Conjoint Associate Professor Murray Cairns
SchemeRole
Postgraduate Research ScholarshipInvestigator
Total AmountFunding StartFunding Finish
$23,75020072010
GNo:G0187724

The functional characterization of schizophrenia-associated non-coding RNA expression$23,750
Funding Body: Schizophrenia Research Institute

Project Team
Associate Professor Paul Tooney, Conjoint Associate Professor Murray Cairns
SchemeRole
Postgraduate Research ScholarshipInvestigator
Total AmountFunding StartFunding Finish
$23,75020072010
GNo:G0187725

Investigation of Genetic and epigenetic mechanism underlying dysregulation of RGS4 in schizophrenia$8,702
Funding Body: University of Newcastle

Project Team
Associate Professor Paul Tooney, Conjoint Associate Professor Murray Cairns
SchemeRole
Pilot GrantInvestigator
Total AmountFunding StartFunding Finish
$8,70220072007
GNo:G0187862

2006 (1 grants)

Investigation of miRNAs in schizophrenia$20,000
Funding Body: University of Newcastle

Project Team
Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Professor Rodney Scott
SchemeRole
Pilot GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020062006
GNo:G0186685
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Research Supervision

Number of current supervisions11
Total current UoN PhD EFTSL3.6

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20142018PhD (Medical Biochemistry)Principal SupervisorPhenotypic Analysis of miRNA in Brain Function and Dysfunction
20142018PhD (Medical Genetics)Principal SupervisorIntegrated Systems Analysis of Schizophrenia
20122016PhD (Anatomy)Co-SupervisorRole of miRNA in Addiction Vulnerability
20122016PhD (Medical Genetics)Co-SupervisorGene Expression in Brain of Hfe-/-xTfr2mut Mouse, A Model of Human Iron Overload
20112015PhD (Medical Biochemistry)Principal SupervisorRoles of Post-Transcriptional Gene Silencing in the Functional Regulation of Neuronal Gene Expression and Plasticity
20112015PhD (Medical Biochemistry)Principal SupervisorThe Role of miRNA and Post-Transcriptional Gene Silencing in Mediating the Mammalian Brains Response to Environmental Stress During Development and Ageing
20112015PhD (Medical Biochemistry)Co-SupervisorAn Investigation into Micro-RNA Regulation of Tetraspanins CD151 and CD9 in Breast and Prostate Cancer Progression
20102013PHD Medical Science
University of Sydney
Co-SupervisorGenome-wide Gene and MicroRNA expression analysis of HIV and HCV infections in humans and biomarker development
20082008Honours Biol Sc Not Elsewhere Classifd
University of Newcastle
Principal SupervisorINVESTIGATION OF SCHIZOPHRENIA ASSOCIATED GENE AND MIRNA EXPRESSION IN THE DORSOLATERAL PREFRONTAL CORTEX
20072010PHD Medical Science
University of Newcastle
Principal SupervisorGene Silencing in the Pathogenesis of Schizophrenia
20072010PHD Medical Science
University of Newcastle
Principal SupervisorFunctional Characterisation of Schizophrenia Associated Non-coding RNA Expression.

Past Supervision

YearProgramSupervisor TypeResearch Title
2014M Philosophy (Medical Genetic)Co-SupervisorGene Expression in the Brain of Mutant Mouse Models of Human Iron Overload
2013PhD(Experimental Pharmacology)Co-SupervisorFunctional Analysis of Gene and microRNA Expression Profiling in Schizophrenia: Brain, Blood and Antipsychotics
2013PhD(Experimental Pharmacology)Principal SupervisorPost-Transcriptional Gene Regulation in Schizophrenia, Antipsychotic Drug Treatment and the Developing Brain
2013PhD(Experimental Pharmacology)Principal SupervisorGenomic Characterisation of Small RNA-Mediated Post-Transcriptional Gene Regulation
2011PhD(Experimental Pharmacology)Principal SupervisorPost-transcriptional Gene Silencing in Neuronal Differentiation, Development and Schizophrenia
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Conjoint Associate Professor Murray Cairns

Work Phone(02) 4921 8670
Fax(02) 4921 7903
Email
PositionConjoint Associate Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaPharmacy and Experimental Pharmacology
Office
MSB512,
Medical Sciences Building,
Callaghan
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/murray-cairns