Staff Profile
Career Summary
Biography
Hubert Hondermarck is Professor of Medical Biochemistry. He obtained a PhD in neurobiochemistry and was a post-doctoral fellow at the University of California Irvine where he investigated growth factor signalling in neuronal cells using proteomics. He took an academic position at the University of Lille (France) in 1993 and started working on breast cancer cell growth and metastasis. He became full Professor in 1998 and a member of the "Institut Universitaire de France" in 2002. He created and directed for 10 years a research unit of the French Institute of Health and Medical Research (INSERM) studying breast cancer cell signalling. In 2011, he moved to the University of Newcastle Australia, to start a new group investigating the role of neurotrophic factors in various tumours, with a particular interest for their clinical utility as biomarkers and therapeutic targets. His long-term interest is in the relationship between the nervous system and cancer.
Hubert Hondermarck has published 78 PubMed referenced articles on cancer cell biology and cancer proteomics http://www.ncbi.nlm.nih.gov/pubmed?term=hondermarck. He has edited a book on biomedical and pharmaceutical applications of proteomics http://www.springerlink.com/content/978-1-4020-2322-4/. He has two internationally issued patents and several collaborations and research contracts with biopharmaceutical companies.
Hubert Hondermarck is on the Editorial Board of: Molecular and Cellular Proteomics (ASBMB), Proteomics Clinical Applications (Wiley), Recent Patent on Anti-Cancer Drug Discovery (Bentham), Open Cancer Journal (Bentham) and Frontiers in Molecular and Cellular Endocrinology (Frontiers Media). He is a member of the Board of Directors of the Human Proteome Organization (HUPO) since 2006.
Qualifications
- PhD (Life Sciences & Health), University of Lille - France, 19/12/1990
Research
Research keywords
- Cancer Biology and Translational Cancer Research
- Proteomics
Research expertise
Tumor cell growth and metastasis / Growth Factor Signalling / Cancer proteomics / Neurotrophins and their receptors / Breast cancer.
Recent selected publications by Hubert Hondermarck:
Demont Y, Corbet C, Page A, Ataman-Önal Y, Choquet-Kastylevsky G, Fliniaux I, Le Bourhis X, Toillon RA, Bradshaw RA, Hondermarck H. Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein. J Biol Chem. 2012;287:1923-31.
Vanhecke E, Adriaenssens E, Verbeke S, Meignan S, Germain E, Berteaux N, Nurcombe V, Le Bourhis X, Hondermarck H.Brain-derived neurotrophic factor and neurotrophin-4/5 are expressed in breast cancer and can be targeted to inhibit tumor cell survival. Clin Cancer Res. 2011;17:1741-52.
Joubel A, Chalkley RJ, Medzihradszky KF, Hondermarck H, Burlingame AL. Identification of new p53 acetylation sites in COS-1 cells. Mol Cell Proteomics. 2009;8:1167-73.
Adriaenssens E, Vanhecke E, Saule P, Mougel A, Page A, Romon R, Nurcombe V, Le Bourhis X, Hondermarck H.Nerve growth factor is a potential therapeutic target in breast cancer. Cancer Res. 2008;68:346-51.
Hondermarck H, Tastet C, El Yazidi-Belkoura I, Toillon RA, Le Bourhis X. Proteomics of breast cancer: the quest for markers and therapeutic targets. J Proteome Res 2008;7:1403-11.
Fields of Research
| Code | Description | Percentage |
|---|---|---|
| 111201 | Cancer Cell Biology | 60 |
| 110106 | Medical Biochemistry: Proteins And Peptides (Incl. Medical Proteomics) | 40 |
Teaching
Teaching keywords
- Biochemistry
- Cancer Cell Biology
Teaching expertise
Head of discipline for Medical Biochemistry.
Grants and Funding
Summary
| Number of grants | 8 |
|---|---|
| Total funding | $855,790 |
For project grants received where the lead institution is other than the University of Newcastle, details are shown in italics.
Click on a grant title below to expand the full details for that specific grant.
2013 (4 grants)
Triple Quadrupole Mass Spectrometer with nano-infusion for targeted protein quantification$300,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Doctor Mark Baker, Laureate Professor John Aitken, Professor Bogdan Dlugogorski, Professor Hubert Hondermarck | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $300,000 | 2013 | 2013 |
| GNo:G1200137 | ||
Leica TP 1020 Automatic Tissue Processor for histology applications$35,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Doctor Pradeep Tanwar, Professor Eileen McLaughlin, Professor Xu Dong Zhang, Professor Robert Callister, Associate Professor Phillip Dickson, Professor Hubert Hondermarck, Doctor Jean-Marie Sontag, Professor Dirk Van Helden, Doctor Doug Smith, Doctor Phil Jobling, Associate Professor Estelle Sontag, Associate Professor Paul Tooney, Doctor Susan Hua, Doctor Janet Holt, Doctor Jay Horvat, Associate Professor Liz Milward, Professor Adam McCluskey, Associate Professor Brett Nixon, Doctor Rebecca Lim, Associate Professor Alan Brichta | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $35,000 | 2013 | 2013 |
| GNo:G1201185 | ||
Ultra-Low Temperature Cryogenic Freezer$24,596
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Doctor Jude Weidenhofer, Doctor Rick Thorne, Doctor Kathryn Skelding, Doctor Nikki Verrills, Doctor Pradeep Tanwar, Associate Professor Phillip Dickson, Doctor Murray Cairns, Professor Hubert Hondermarck, Professor Xu Dong Zhang, Associate Professor Estelle Sontag, Doctor Chen Chen Jiang, Associate Professor Liz Milward, Doctor Jean-Marie Sontag, Associate Professor Paul Tooney, Doctor Severine Roselli, Doctor Matt Dun, Doctor Chris Dayas, Doctor Lin Kooi Ong, Professor Dirk Van Helden, Mr Ben Copeland, Ms Gabrielle Briggs, Conjoint Professor Leonie Ashman, Professor John Rostas | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $24,596 | 2013 | 2013 |
| GNo:G1201189 | ||
12th World Congress of the Human Proteome Organization (HUPO), Yokohama Japan, 14 - 18 September 2013$1,500
Funding Body: University of Newcastle - Faculty of Health
| Project Team | ||
|---|---|---|
| Professor Hubert Hondermarck | ||
| Scheme | Role | |
| Travel Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $1,500 | 2013 | 2013 |
| GNo:G1300864 | ||
2012 (4 grants)
The Hunter Cancer Biobank (HCB): Maximising community value through validation, annotation and distribution throughout NSW$292,300
Funding Body: Cancer Institute NSW
| Project Team | ||
|---|---|---|
| Professor John Forbes, Conjoint Professor Stephen Ackland, Professor Rodney Scott, Conjoint Associate Professor Barbara Young, Professor Hubert Hondermarck, Conjoint Professor Leonie Ashman, Professor Xu Dong Zhang, Doctor Kelly Kiejda, Doctor Nikki Verrills, Doctor Jennette Sakoff, Ms Janine Lombard, Doctor Jude Weidenhofer, Doctor Pradeep Tanwar | ||
| Scheme | Role | |
| Infrastructure Grants | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $292,300 | 2012 | 2014 |
| GNo:G1200798 | ||
High-Resolution Isoelectric Phosphoprotein Signalling System for Signalling Research, Biomarker Validation and Drug Development – Equipment Grant$143,394
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Rick Thorne, Professor Xu Dong Zhang, Professor Hubert Hondermarck, Conjoint Professor Stephen Ackland, Doctor Lisa Lincz, Doctor Jennette Sakoff, Conjoint Professor Leonie Ashman | ||
| Scheme | Role | |
| Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $143,394 | 2012 | 2012 |
| GNo:G1200555 | ||
Microscopic illumination system for advanced fluorescent protein technology$34,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Doctor Rick Thorne, Professor Xu Dong Zhang, Doctor Murray Cairns, Doctor Nikki Verrills, Doctor Charles De Bock, Doctor Jude Weidenhofer, Doctor Severine Roselli, Doctor Kathryn Skelding, Conjoint Professor Leonie Ashman, Professor Hubert Hondermarck | ||
| Scheme | Role | |
| Equipment Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $34,000 | 2012 | 2012 |
| GNo:G1100983 | ||
Does Ubiquitination control the altered expression of tetraspanin proteins in Breast Cancer?$25,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Jude Weidenhofer, Conjoint Professor Leonie Ashman, Professor Hubert Hondermarck | ||
| Scheme | Role | |
| Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $25,000 | 2012 | 2012 |
| GNo:G1200169 | ||
Research Supervision
| Number of current supervisions | 5 |
|---|---|
| Total current UoN PhD EFTSL | 1.55 |
For supervisions undertaken at an institution other that the University of Newcastle, details are shown in italics, and the institution name is listed below the program name.
Current Supervision
| Commenced | Proposed Completion | Program | Supervisor Type | Research Title |
|---|---|---|---|---|
| 2013 | 2017 | PhD (Medical Biochemistry) | Co-Supervisor | Identification and Targeting of Novel Biomarkers of Ovarian Cancer Stem Cells |
| 2013 | 2017 | PhD (Pharmacy) | Co-Supervisor | Multifunctional Nanomedicines Based on Albumin for Targeted Cancer Therapy |
| 2013 | 2017 | PhD (Medical Biochemistry) | Co-Supervisor | Studies on Effect of P13K Inhibitors on P13K/Akt Signaling Pathway in Akt Mutant and Wild Type Murine Models to Control Endometrial Cancer |
| 2012 | 2015 | PhD (Medical Biochemistry) | Principal Supervisor | The Precursor for Nerve Growth Factor (proNGF) as a Biomarker and Therapeutic Target in Breast Cancer |
| 2011 | 2015 | PhD (Medical Biochemistry) | Co-Supervisor | Roles of Fat in Cadherins in Neuronal Differentiation and in Progression of Neurological Malignancies |
Professor Hubert Hondermarck
| Work Phone | (02) 4921 8830 |
|---|---|
| Fax | (02) 4921 7903 |
| Hubert.Hondermarck@newcastle.edu.au | |
| Position | Professor School of Biomedical Sciences and Pharmacy Faculty of Health and Medicine |
| Focus Area | Medical Biochemistry |
| Office | LS3-35, Life Sciences, Callaghan University Drive Callaghan NSW 2308 Australia |
| URL: | www.newcastle.edu.au/profile/hubert-hondermarck |
