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Career Summary

Biography

Hubert Hondermarck is Professor of Medical Biochemistry. He obtained a PhD in neurobiochemistry and was a post-doc fellow at the University of California Irvine where he investigated growth factor signalling in neuronal cells using proteomics. He took an academic position at the University of Lille (France) in 1993 to work on signaling of breast cancer cell growth and metastasis. He became full Professor in 1998 and a member of the "Institut Universitaire de France" in 2002. He created a research unit of the French Institute of Health and Medical Research (INSERM) studying breast cancer cell signalling and directed it for 10 years. In 2011, he moved to the University of Newcastle Australia, to start a new group investigating the role of neurotrophic factors in various tumours, with a particular interest for their clinical utility as biomarkers and therapeutic targets. His long-term interest is in the relationship between the nervous system and cancer.

Hubert Hondermarck has published 78 PubMed referenced articles on cancer cell biology and cancer proteomics http://www.ncbi.nlm.nih.gov/pubmed?term=hondermarck. He has edited a book on biomedical and pharmaceutical applications of proteomics and has two internationally issued patents and several collaborations and research contracts with biopharmaceutical companies.

Hubert Hondermarck is on the Editorial Board of: Molecular and Cellular Proteomics (ASBMB), Proteomics Clinical Applications (Wiley), Recent Patent on Anti-Cancer Drug Discovery (Bentham), Open Cancer Journal (Bentham) and Frontiers in Endocrinology (Frontiers Media). He is a member of the Board of Directors of the Human Proteome Organization (HUPO).

Qualifications

  • PhD (Life Sciences & Health), University of Lille - France, 19/12/1990

Research

Research keywords

  • Cancer Biology and Translational Cancer Research
  • Growth factor signaling
  • Proteomics

Research expertise

Tumor cell growth and metastasis / Growth Factor Signalling / Cancer proteomics / Neurotrophins and their receptors / Breast cancer.

Recent selected publications by Hubert Hondermarck:

Pundavela J, Demont Y, Jobling P, Lincz L, Roselli S, Thorne RF, Bond D, Bradshaw RA, Marjorie M Walker, Hondermarck H. ProNGF correlates with Gleason score and is a potential driver of nerve infiltration in prostate cancer. Am J Pathol. 2014, in press.

Bailly F, Toillon RA, Tomavo O, Jouy N, Hondermarck H, Cotelle P. Antiproliferative and apoptotic effects of the oxidative dimerization product of methyl caffeate on human breast cancer cells. Bioorg Med Chem Lett. 2013, 23(2):574-8.

Hondermarck H. Neurotrophins and their receptors in breast cancer. Cytokine & Growth Factor Rev. 2012, 23(6):357-65.

Demont Y, Corbet C, Page A, Ataman-Önal Y, Choquet-Kastylevsky G, Fliniaux I, Le Bourhis X, Toillon RA, Bradshaw RA, Hondermarck H. Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein. J Biol Chem. 2012;287:1923-31.

Vanhecke E, Adriaenssens E, Verbeke S, Meignan S, Germain E, Berteaux N, Nurcombe V, Le Bourhis X, Hondermarck H.Brain-derived neurotrophic factor and neurotrophin-4/5 are expressed in breast cancer and can be targeted to inhibit tumor cell survival. Clin Cancer Res. 2011;17:1741-52.

Joubel A, Chalkley RJ, Medzihradszky KF, Hondermarck H, Burlingame AL. Identification of new p53 acetylation sites in COS-1 cells. Mol Cell Proteomics. 2009;8:1167-73.

Languages

  • French

Fields of Research

CodeDescriptionPercentage
111201Cancer Cell Biology60
110106Medical Biochemistry: Proteins And Peptides (Incl. Medical Proteomics)40

Teaching

Teaching keywords

  • Biochemistry
  • Cancer Cell Biology

Teaching expertise

Head of discipline for Medical Biochemistry.

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Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (16 outputs)

YearCitationAltmetricsLink
2013Bailly F, Toillon R-A, Tomavo O, Jouy N, Hondermarck H, Cotelle P, 'Antiproliferative and apoptotic effects of the oxidative dimerization product of methyl caffeate on human breast cancer cells', BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 23 574-578 (2013) [C1]
2012Demont Y, Corbet C, Page A, Ataman-Onal Y, Choquet-Kastylevsky G, Fliniaux I, et al., 'Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein', Journal of Biological Chemistry, 287 1923-1931 (2012) [C1]
2011Vanhecke E, Adriaenssens E, Verbeke S, Meignan S, Germain E, Le Bourhis X, et al., 'Brain-derived neurotrophic factor and neurotrophin-4/5 are expressed in breast cancer and can be targeted to inhibit tumor cell survival', Clinical Cancer Research, 17 1741-1752 (2011) [C1]
2011Wilmet J-P, Tastet C, Desruelles E, Ziental-Gelus N, Blanckaert V, Hondermarck H, Le Bourhis X, 'Proteome changes induced by overexpression of the p75 neurotrophin receptor (p75(NTR)) in breast cancer cells', INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 55 801-809 (2011) [C1]
2010Romon R, Adriaenssens E, Lagadec C, Germain E, Hondermarck H, Le Bourhis X, ' Nerve growth factor promotes breast cancer angiogenesis by activating multiple pathways', Molecular Cancer, 9 157-157 (2010) [C1]
2010Lagadec C, Romon R, Tastet C, Meignan S, Com E, Page A, et al., ' Ku86 is important for TrkA overexpression-induced breast cancer cell invasion', PROTEOMICS - Clinical Applications, 4 580-590 (2010) [C1]
2010Le Bourhis X, Romon R, Hondermarck H, ' Role of endothelial progenitor cells in breast cancer angiogenesis: from fundamental research to clinical ramifications', Breast Cancer Research and Treatment, 120 17-24 (2010) [C1]
2010Verbeke S, Meignan S, Lagadec C, Germain E, Hondermarck H, Le Bourhis X, Adriaenssens E, 'Overexpression of p75 increases survival of breast cancer cells through p21', Cellular Signalling, 22 1864-1873 (2010) [C1]
2009Strande V, Canelle L, Tastet C, Burlet-Schiltz O, Monsarrat B, Hondermarck H, ' The proteome of the human breast cancer cell line MDA-MB-231: Analysis by LTQ-Orbitrap mass spectrometry', PROTEOMICS - CLINICAL APPLICATIONS, 3 41-50 (2009) [C1]
2009Lagadec C, Meignan S, Adriaenssens E, Foveau B, Vanhecke E, Romon R, et al., ' TrkA overexpression enhances growth and metastasis of breast cancer cells', Oncogene, 28 1960-1970 (2009) [C1]
2009Joubel A, Chalkley RJ, Medzihradszky KF, Hondermarck H, Burlingame AL, ' Identification of New p53 Acetylation Sites in COS-1 Cells', Molecular & Cellular Proteomics, 8 1167-1173 (2009) [C1]
2009Collins BC, Lau TYK, O'Connor DP, Hondermarck H, 'Cancer proteomics - An evolving battlefield: Conference on cancer proteomics 2009: Mechanistic insights, technological advances & molecular medicine', EMBO Reports, 10 1202-1205 (2009) [E3]
2008Adriaenssens E, Vanhecke E, Saule P, Mougel A, Page A, Romon R, et al., ' Nerve Growth Factor Is a Potential Therapeutic Target in Breast Cancer', Cancer Research, 68 346-351 (2008) [C1]
2008Berteaux N, Aptel N, Cathala G, Genton C, Coll J, Daccache A, et al., ' A Novel H19 Antisense RNA Overexpressed in Breast Cancer Contributes to Paternal IGF2 Expression', Molecular and Cellular Biology, 28 6731-6745 (2008) [C1]
2008Hondermarck H, Tastet C, El Yazidi-Belkoura I, Toillon R-A, Le Bourhis X, ' Proteomics of Breast Cancer: The Quest for Markers and Therapeutic Targets', Journal of Proteome Research, 7 1403-1411 (2008) [C1]
2008Hondermarck H, ' Nerve Growth Factor: The Dark Side of the Icon', The American Journal of Pathology, 172 865-867 (2008) [C3]
Show 13 more

Review (1 outputs)

YearCitationAltmetricsLink
2012Hondermarck H, 'Neurotrophins and their receptors in breast cancer', Cytokine & Growth Factor Reviews (2012) [C1]

Conference (2 outputs)

YearCitationAltmetricsLink
2013Ahmed AF, De Bock CE, Sontag E, Hondermarck H, Thorne RF, 'The functional role of Fat1 cadherin in the differentiation and proliferation of SH-SY5Y neuroblastoma cells', -, Pokolbin, NSW, Australia (2013) [E3]
2012Roselli SM, Moscato PA, Scott R, Hondermarck H, 'Breast cancer proteomics: Integrating the data with genomics and histology towards clinical applications', 18th Proteomics Symposium. Delegate Handbook, Lorne, Vic (2012) [E3]
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Grants and Funding

Summary

Number of grants9
Total funding$1,138,404

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (1 grants)

High Throughput Image Capture Platform for Translational Cancer Research$282,614
Funding Body: Cancer Institute NSW

Project Team
Conjoint Professor Stephen Ackland, Professor Rodney Scott, Professor John Forbes, Professor Xu Dong Zhang, Professor Marjorie Walker, Professor Hubert Hondermarck, Doctor Craig Gedye, Doctor Rick Thorne, Mr Loui Rassam, Doctor Stephen Braye
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$282,61420142014
GNo:G1400626

2013 (4 grants)

Triple Quadrupole Mass Spectrometer with nano-infusion for targeted protein quantification$300,000
Funding Body: University of Newcastle

Project Team
Doctor Mark Baker, Laureate Professor John Aitken, Conjoint Professor Bogdan Dlugogorski, Professor Hubert Hondermarck
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$300,00020132013
GNo:G1200137

Leica TP 1020 Automatic Tissue Processor for histology applications$35,000
Funding Body: NHMRC (National Health & Medical Research Council)

Ultra-Low Temperature Cryogenic Freezer$24,596
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Jude Weidenhofer, Doctor Rick Thorne, Doctor Kathryn Skelding, Doctor Nikki Verrills, Doctor Pradeep Tanwar, Associate Professor Phillip Dickson, Conjoint Associate Professor Murray Cairns, Professor Hubert Hondermarck, Professor Xu Dong Zhang, Associate Professor Estelle Sontag, Doctor Chen Chen Jiang, Associate Professor Liz Milward, Doctor Jean-Marie Sontag, Associate Professor Paul Tooney, Doctor Severine Roselli, Doctor Matt Dun, Doctor Chris Dayas, Doctor Lin Kooi Ong, Professor Dirk Van Helden, Mr Ben Copeland, Doctor Gabrielle Briggs, Emeritus Professor Leonie Ashman, Emeritus Professor John Rostas
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$24,59620132013
GNo:G1201189

12th World Congress of the Human Proteome Organization (HUPO), Yokohama Japan, 14 - 18 September 2013$1,500
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Professor Hubert Hondermarck
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,50020132013
GNo:G1300864

2012 (4 grants)

The Hunter Cancer Biobank (HCB): Maximising community value through validation, annotation and distribution throughout NSW$292,300
Funding Body: Cancer Institute NSW

Project Team
Professor John Forbes, Conjoint Professor Stephen Ackland, Professor Rodney Scott, Conjoint Associate Professor Barbara Young, Professor Hubert Hondermarck, Emeritus Professor Leonie Ashman, Professor Xu Dong Zhang, Doctor Kelly Kiejda, Doctor Nikki Verrills, Doctor Jennette Sakoff, Ms Janine Lombard, Doctor Jude Weidenhofer, Doctor Pradeep Tanwar
SchemeRole
Infrastructure GrantsInvestigator
Total AmountFunding StartFunding Finish
$292,30020122014
GNo:G1200798

High-Resolution Isoelectric Phosphoprotein Signalling System for Signalling Research, Biomarker Validation and Drug Development – Equipment Grant$143,394
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Rick Thorne, Professor Xu Dong Zhang, Professor Hubert Hondermarck, Conjoint Professor Stephen Ackland, Doctor Lisa Lincz, Doctor Jennette Sakoff, Emeritus Professor Leonie Ashman
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$143,39420122012
GNo:G1200555

Microscopic illumination system for advanced fluorescent protein technology$34,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Rick Thorne, Professor Xu Dong Zhang, Conjoint Associate Professor Murray Cairns, Doctor Nikki Verrills, Doctor Charles De Bock, Doctor Jude Weidenhofer, Doctor Severine Roselli, Doctor Kathryn Skelding, Emeritus Professor Leonie Ashman, Professor Hubert Hondermarck
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$34,00020122012
GNo:G1100983

Does Ubiquitination control the altered expression of tetraspanin proteins in Breast Cancer?$25,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jude Weidenhofer, Emeritus Professor Leonie Ashman, Professor Hubert Hondermarck
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$25,00020122012
GNo:G1200169
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Research Supervision

Number of current supervisions8
Total current UoN PhD EFTSL2.45

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20142018PhD (Medical Biochemistry)Co-SupervisorTo Investigate the Interaction of Bone Marrow Derived Endothelial Progenitor Cells (EPCs) with Ovarian Cancer Stem Cells (CSCs) in Tumor Angiogenesis Invasion
20142018PhD (Medical Biochemistry)Principal SupervisorProNGF in Pancreatic Cancer
20142016PhD (Human Physiology)Co-SupervisorTumour Innervation and Trophic Factors
20132017PhD (Medical Biochemistry)Co-SupervisorIdentification and Targeting of Novel Biomarkers of Ovarian Cancer Stem Cells
20132017PhD (Pharmacy)Co-SupervisorMultifunctional Nanomedicines Based on Albumin for Targeted Cancer Therapy
20132017PhD (Medical Biochemistry)Co-SupervisorStudies on Effect of P13K Inhibitors on P13K/Akt Signaling Pathway in Akt Mutant and Wild Type Murine Models to Control Endometrial Cancer
20122015PhD (Medical Biochemistry)Principal SupervisorThe Precursor for Nerve Growth Factor (proNGF) as a Biomarker and Therapeutic Target in Breast Cancer
20112015PhD (Medical Biochemistry)Co-SupervisorRoles of Fat in Cadherins in Neuronal Differentiation and in Progression of Neurological Malignancies
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Professor Hubert Hondermarck

Work Phone(02) 4921 8830
Fax(02) 4921 7903
Email
PositionProfessor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaMedical Biochemistry
Office
LS3-35,
Life Sciences,
Callaghan
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/hubert-hondermarck