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Hubert Hondermarck is Professor of Medical Biochemistry. He obtained a PhD in neurobiochemistry at the University in Lille (1990, France) and was a post-doc at the University of California Irvine (1990-1993) where he investigated the mechanisms of neuronal cell differentiation using proteomics. He was appointed on an academic position at the University of Lille (1993) to work on signaling of breast cancer cell growth and metastasis. He became full Professor in 1998 and a member of the "Institut Universitaire de France" (Chair of cancer proteomics) in 2002. He founded a research unit of the French Institute of Health and Medical Research (U908 INSERM, growth factor signaling and functional proteomics in breast cancer) and directed it for 10 years. In 2011, he moved to the University of Newcastle to start a new program on the function of neurotrophic growth factors and the impact of the nervous system in cancer initiation and progression.

Scientific production. 83 PubMed referenced articles on cancer cell biology and proteomics and  2 internationally issued patents in collaboration with biopharmaceutical companies.

Committees and Boards. President of the French Proteomics Society (SFEAP, 2005-2007) and current member of the Board of Directors of the Human Proteome Organization (HUPO). Member of the following Editorial Boards: Molecular and Cellular Proteomics (ASBMB), Proteomics Clinical Applications (Wiley), Open Cancer Journal (Bentham) and Frontiers in Endocrinology (Frontiers Media).

Research. Hubert Hondermarck's group works on the crosstalk between nerves and cancer cells (Figure below), and its impact on tumour progression. Until recently it was thought that neurons were not actively involved in cancer. However, recent evidence in prostate and breast cancers, including from our group (Pundavela et al Am J Pathol. 2014, Jobling et al Cancer Res. 2015), have shown that nerves promotes tumour progression and that denervation can suppress both the development of the primary tumor and the outburst of metastases. The objective of our research is to identify the molecular mediators of the crosstalk between nerve and cancer cells, which constitute new and innovative biomarkers and therapeutic targets.

 Nerve-cancer cell crosstalk. Nerves infiltrate the tumor microenvironment and stimulate cancer cell growth and metastasis through the secretion of neurotransmitters (such as catecholamines, acetylcholine and neuropeptides) initiating signaling pathways for growth and invasion in cancer cells after binding to neurotransmitter receptors (NTRs). Conversely, nerve infiltration in the tumor is mediated through the liberation of neurotrophic growth factors (such as NGF) by cancer cells, resulting in neuron outgrowth (axonogenesis or neo-neurogenesis), as well as autocrine stimulation of cancer cells via the stimulation of corresponding receptor tyrosine kinases (RTKs). This reciprocal interaction fuels tumor development and also impacts the microenvironment, as the liberated neurotransmitters and growth factors can also act on endothelial and immune cells, then contributing to tumor inflammation and neo-angiogenesis. Cancer-induced pain can also be a consequence of tumor innervation. PLCγ, phospholipase C gamma; cAMP, cyclic adenosine monophosphate; STAT, signal transducer activator of transcription; PKC, protein kinase C; MAPK, mitogen-activated protein kinases. From Jobling et al. Cancer Research 2015 75(8);1-5.

Our methodologies include analysis of human tumour samples, cell cultures, in vivo experiments, proteomics and mass spectrometry analysis. We work in collaboration with neurobiologists, pathologists, clinicians and private companies to translate the results of our research into practical outcomes in oncology.

Most recent publications

Roselli S, Pundavela J, Demont Y, Faulkner S, Sheridan K, AttiaJ, Jiang CC, Zhang XD, Walker MM, Hondermarck H. Sortilin is associated with breast cancer aggressiveness and contributes to tumour cell adhesion and invasion. Oncotarget 2015, Epub ahead of print 18 March.

Faulkner, S., Dun, M.D., Hondermarck, H. Proteogenomics: emergence and promise. Cellular and Molecular Life Sciences. 2015 72(:953-7.

Jobling P, Pundavela J, Oliverira SMR, Roselli S, Walker MM, Hondermarck H. Nerve-cancer cell crosstalk: a novel promoter of tumor progression. Cancer Res. 2015, 75, 1-5.

Pundavela, J., Demont, Y., Jobling, P., Lincz, L.F., Roselli, S., Thorne, R., Bond, D., Bradshaw, R.A., Walker, M.M., Hondermarck, H. ProNGF correlates with Gleason score and is a potential driver of nerve infiltration in prostate cancer. Am J Pathol. 2014. 184, 3156-62.

Teaching. Biochemistry, proteomics, cancer biology, bioinformatics.

Administrative responsabilities. Head of the Discipline of Medical Biochemistry (Faculty of Health and Medicine).


  • PhD (Life Sciences & Health), University of Lille - France, 19/12/1990


Research keywords

  • -

Research expertise

Fields of Research

111201Cancer Cell Biology60
110106Medical Biochemistry: Proteins And Peptides (Incl. Medical Proteomics)40


For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (21 outputs)

2015Faulkner S, Dun MD, Hondermarck H, 'Proteogenomics: emergence and promise.', Cell Mol Life Sci, 72 953-957 (2015)
2015Blanckaert V, Kerviel V, Lépinay A, Joubert-Durigneux V, Hondermarck H, Chénais B, 'Docosahexaenoic acid inhibits the invasion of MDA-MB-231 breast cancer cells through upregulation of cytokeratin-1.', Int J Oncol, (2015)
2015Jobling P, Pundavela J, Oliveira SM, Roselli S, Walker MM, Hondermarck H, 'Nerve-Cancer Cell Cross-talk: A Novel Promoter of Tumor Progression.', Cancer Res, (2015)
2014Pundavela J, Demont Y, Jobling P, Lincz LF, Roselli S, Thorne RF, et al., 'ProNGF correlates with Gleason score and is a potential driver of nerve infiltration in prostate cancer', American Journal of Pathology, 184 3156-3162 (2014) [C1]
2014Bradshaw RA, Pundavela J, Biarc J, Chalkley RJ, Burlingame AL, Hondermarck H, 'NGF and ProNGF: Regulation of neuronal and neoplastic responses through receptor signaling', Advances in Biological Regulation, (2014)
2013Bailly F, Toillon R-A, Tomavo O, Jouy N, Hondermarck H, Cotelle P, 'Antiproliferative and apoptotic effects of the oxidative dimerization product of methyl caffeate on human breast cancer cells', BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 23 574-578 (2013) [C1]
2012Demont Y, Corbet C, Page A, Ataman-Onal Y, Choquet-Kastylevsky G, Fliniaux I, et al., 'Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein', Journal of Biological Chemistry, 287 1923-1931 (2012) [C1]
2011Wilmet J-P, Tastet C, Desruelles E, Ziental-Gelus N, Blanckaert V, Hondermarck H, Le Bourhis X, 'Proteome changes induced by overexpression of the p75 neurotrophin receptor (p75(NTR)) in breast cancer cells', INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 55 801-809 (2011) [C1]
2011Vanhecke E, Adriaenssens E, Verbeke S, Meignan S, Germain E, Berteaux N, et al., 'Brain-derived neurotrophic factor and neurotrophin-4/5 are expressed in breast cancer and can be targeted to inhibit tumor cell survival', Clinical Cancer Research, 17 1741-1752 (2011) [C1]
2010Le Bourhis X, Romon R, Hondermarck H, 'Role of endothelial progenitor cells in breast cancer angiogenesis: From fundamental research to clinical ramifications', Breast Cancer Research and Treatment, 120 17-24 (2010) [C1]
2010Verbeke S, Meignan S, Lagadec C, Germain E, Hondermarck H, Adriaenssens E, Le Bourhis X, 'Overexpression of p75NTR increases survival of breast cancer cells through p21waf1 ', Cellular Signalling, 22 1864-1873 (2010) [C1]
2010Lagadec C, Romon R, Tastet C, Meignan S, Com E, Page A, et al., 'Ku86 is important for TrkA overexpression-induced breast cancer cell invasion', Proteomics - Clinical Applications, 4 580-590 (2010) [C1]
2010Romon R, Adriaenssens E, Lagadec C, Germain E, Hondermarck H, Le Bourhis X, 'Nerve growth factor promotes breast cancer angiogenesis by activating multiple pathways', Molecular Cancer, 9 (2010) [C1]
2009Lagadec C, Meignan S, Adriaenssens E, Foveau B, Vanhecke E, Romon R, et al., 'TrkA overexpression enhances growth and metastasis of breast cancer cells', Oncogene, 28 1960-1970 (2009) [C1]
2009Joubel A, Chalkley RJ, Medzihradszky KF, Hondermarck H, Burlingame AL, 'Identification of new p53 acetylation sites in COS-1 cells', Molecular and Cellular Proteomics, 8 1167-1173 (2009) [C1]
2009Strande V, Canelle L, Tastet C, Burlet-Schiltz O, Monsarrat B, Hondermarck H, 'The proteome of the human breast cancer cell line MDA-MB-231: Analysis by LTQ-Orbitrap mass spectrometry', Proteomics - Clinical Applications, 3 41-50 (2009) [C1]
2009Collins BC, Lau TYK, O'Connor DP, Hondermarck H, 'Cancer proteomics - An evolving battlefield: Conference on cancer proteomics 2009: Mechanistic insights, technological advances & molecular medicine', EMBO Reports, 10 1202-1205 (2009) [E3]
2008Hondermarck H, Tastet C, Yazidi-Belkoura IE, Toillon R-A, Bourhis XL, 'Proteomics of breast cancer: The quest for markers and therapeutic targets', Journal of Proteome Research, 7 1403-1411 (2008) [C1]
2008Adriaenssens E, Vanhecke E, Saule P, Mougel A, Page A, Romon R, et al., 'Nerve growth factor is a potential therapeutic target in breast cancer', Cancer Research, 68 346-351 (2008) [C1]
2008Berteaux N, Aptel N, Cathala G, Genton C, Coll J, Daccache A, et al., 'A novel H19 antisense RNA overexpressed in breast cancer contributes to paternal IGF2 expression', Molecular and Cellular Biology, 28 6731-6745 (2008) [C1]
2008Hondermarck H, 'Nerve Growth Factor: The Dark Side of the Icon', The American Journal of Pathology, 172 865-867 (2008) [C3]
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Review (1 outputs)

2012Hondermarck H, 'Neurotrophins and their receptors in breast cancer', Cytokine & Growth Factor Reviews (2012) [C1]

Conference (6 outputs)

2014Dun MD, Chalkley RJ, Keene S, Bradshaw RA, Hondermarck H, 'Proteomics versus Transcriptomics for the Identification of Cancer Biomarkers: the Case of Brain-derived Metastatic Breast Cancer Cells', MOLECULAR & CELLULAR PROTEOMICS (2014) [E3]

Author URL

Co-authors: MATT DUN

2013Ahmed AF, De Bock CE, Sontag E, Hondermarck H, Thorne RF, 'The functional role of Fat1 cadherin in the differentiation and proliferation of SH-SY5Y neuroblastoma cells', -, Pokolbin, NSW, Australia (2013) [E3]
2012Roselli SM, Moscato PA, Scott R, Hondermarck H, 'Breast cancer proteomics: Integrating the data with genomics and histology towards clinical applications', 18th Proteomics Symposium. Delegate Handbook, Lorne, Vic (2012) [E3]
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Grants and Funding


Number of grants10
Total funding$1,158,404

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Click on a grant title below to expand the full details for that specific grant.

2014 (2 grants)

High Throughput Image Capture Platform for Translational Cancer Research$282,614
Funding Body: Cancer Institute NSW

Project Team
Conjoint Professor Stephen Ackland, Professor Rodney Scott, Professor John Forbes, Professor Xu Dong Zhang, Professor Marjorie Walker, Professor Hubert Hondermarck, Doctor Craig Gedye, Doctor Rick Thorne, Mr Loui Rassam, Doctor Stephen Braye
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish

Prostate Cancer: A new protein for improving diagnosis, prognosis and treatment$20,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Severine Roselli, Professor Hubert Hondermarck
Project GrantInvestigator
Total AmountFunding StartFunding Finish

2013 (4 grants)

Triple Quadrupole Mass Spectrometer with nano-infusion for targeted protein quantification$300,000
Funding Body: University of Newcastle

Project Team
Doctor Mark Baker, Laureate Professor John Aitken, Conjoint Professor Bogdan Dlugogorski, Professor Hubert Hondermarck
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish

Leica TP 1020 Automatic Tissue Processor for histology applications$35,000
Funding Body: NHMRC (National Health & Medical Research Council)

Ultra-Low Temperature Cryogenic Freezer$24,596
Funding Body: NHMRC (National Health & Medical Research Council)

12th World Congress of the Human Proteome Organization (HUPO), Yokohama Japan, 14 - 18 September 2013$1,500
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Professor Hubert Hondermarck
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish

2012 (4 grants)

The Hunter Cancer Biobank (HCB): Maximising community value through validation, annotation and distribution throughout NSW$292,300
Funding Body: Cancer Institute NSW

Project Team
Professor John Forbes, Conjoint Professor Stephen Ackland, Professor Rodney Scott, Conjoint Associate Professor Barbara Young, Professor Hubert Hondermarck, Emeritus Professor Leonie Ashman, Professor Xu Dong Zhang, Doctor Kelly Kiejda, Doctor Nikki Verrills, Doctor Jennette Sakoff, Ms Janine Lombard, Doctor Jude Weidenhofer, Doctor Pradeep Tanwar
Infrastructure GrantsInvestigator
Total AmountFunding StartFunding Finish

High-Resolution Isoelectric Phosphoprotein Signalling System for Signalling Research, Biomarker Validation and Drug Development – Equipment Grant$143,394
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Rick Thorne, Professor Xu Dong Zhang, Professor Hubert Hondermarck, Conjoint Professor Stephen Ackland, Doctor Lisa Lincz, Doctor Jennette Sakoff, Emeritus Professor Leonie Ashman
Project GrantInvestigator
Total AmountFunding StartFunding Finish

Microscopic illumination system for advanced fluorescent protein technology$34,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Rick Thorne, Professor Xu Dong Zhang, Conjoint Associate Professor Murray Cairns, Doctor Nikki Verrills, Doctor Charles De Bock, Doctor Jude Weidenhofer, Doctor Severine Roselli, Doctor Kathryn Skelding, Emeritus Professor Leonie Ashman, Professor Hubert Hondermarck
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish

Does Ubiquitination control the altered expression of tetraspanin proteins in Breast Cancer?$25,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jude Weidenhofer, Emeritus Professor Leonie Ashman, Professor Hubert Hondermarck
Project GrantInvestigator
Total AmountFunding StartFunding Finish

Research Supervision

Number of current supervisions9
Total current UoN PhD EFTSL2.55

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

ProgramSupervisor TypeResearch Title
20142018PhD (Medical Biochemistry)Co-SupervisorTo Investigate the Interaction of Bone Marrow Derived Endothelial Progenitor Cells (EPCs) with Ovarian Cancer Stem Cells (CSCs) in Tumor Angiogenesis Invasion
20142018PhD (Medical Biochemistry)Co-SupervisorWNT Signaling in Uterine Cancer
20142018PhD (Medical Biochemistry)Principal SupervisorProNGF in Pancreatic Cancer
20142016PhD (Human Physiology)Co-SupervisorTumour Innervation and Trophic Factors
20132017PhD (Medical Biochemistry)Co-SupervisorRole of Wnt Signalling in Endometrial Homeostasis and Cancer
20132017PhD (Pharmacy)Co-SupervisorMultifunctional Nanomedicines Based on Albumin for Targeted Cancer Therapy
20132017PhD (Medical Biochemistry)Co-SupervisorRole of Wnt Signalling in Testicular Morphogenesis and Carcinogenesis
20122015PhD (Medical Biochemistry)Principal SupervisorProNGF/NGF and Nerve Infiltration in Prostate and Breast Cancer
20112015PhD (Medical Biochemistry)Co-SupervisorRole of FAT1 Cadherin in Neuronal Differentiation

Professor Hubert Hondermarck

Work Phone(02) 4921 8830
Fax(02) 4921 7903
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaMedical Biochemistry
Life Sciences,
University Drive
Callaghan NSW 2308