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Career Summary

Biography

Hubert Hondermarck is Professor of Medical Biochemistry. He obtained a PhD in neurobiochemistry at the University in Lille (1990, France) and was a post-doc at the University of California Irvine (1990-1993) where he investigated the mechanisms of neuronal cell differentiation using proteomics. He was appointed on an academic position at the University of Lille (1993) to work on signaling of breast cancer cell growth and metastasis. He became full Professor in 1998 and a member of the "Institut Universitaire de France" (Chair of cancer proteomics) in 2002. He founded a research unit of the French Institute of Health and Medical Research (U908 INSERM, growth factor signaling and functional proteomics in breast cancer) and directed it for 10 years. In 2011, he moved to the University of Newcastle to start a new program on the function of neurotrophic growth factors and the impact of the nervous system in cancer initiation and progression.

Hbert Hondermarck is an elected member of the Board of Directors of the Human Proteome Organization (HUPO). He is also in the following Editorial Boards: Molecular and Cellular Proteomics (ASBMB), Proteomics Clinical Applications (Wiley), Open Cancer Journal (Bentham) and Frontiers in Endocrinology (Frontiers Media). He was President of the French proteomics Society (SFEAP)  from 2005 to 2007.

Qualifications

  • PhD (Life Sciences & Health), University of Lille - France, 19/12/1990

Research

Research keywords

  • Growth factors
  • Proteomics
  • Translational cancer research

Research expertise

Hubert Hondermarck's group works on the crosstalk between nerves and cancer cells, and its impact on tumour progression. Until recently it was thought that neurons were not actively involved in cancer. However, recent evidence in prostate and breast cancers, including from our group (Pundavela et al Am J Pathol. 2014, Pundavela et al Mol Oncol 2015, Jobling et al Cancer Res. 2015), have shown that nerves promote tumour progression and that denervation can suppress both the development of the primary tumor and the outburst of metastases. The objective of our research is to identify the molecular mediators of the crosstalk between nerves and cancer cells that may constitute new and innovative biomarkers and therapeutic targets. Our methodologies include the analysis of human tumour samples, cell cultures, in vivo experiments, proteomics and mass spectrometry analysis. We work in collaboration with neurobiologists, pathologists, clinicians and private companies to translate the results of our research into practical outcomes in oncology.

Scientific production: 84 PubMed referenced articles on cancer cell biology and proteomics http://www.ncbi.nlm.nih.gov/pubmed?term=hondermarck, and 2 internationally issued patents in collaboration with biopharmaceutical companies.

Most recent publications:

Pundavela J, Roselli S, Faulkner S, Attia J, Scott RJ, Thorne RF, Bradshaw RA, Walker MM, Jobling P, Hondermarck H. Nerve fibers infiltrate the tumor microenvironment and are associated with nerve growth factor production and lymph node invasion in breast cancer. Molecular Oncol. In press.

Roselli S, Pundavela J, Demont Y, Faulkner S, Sheridan K, AttiaJ, Jiang CC, Zhang XD, Walker MM, Hondermarck H. Sortilin is associated with breast cancer aggressiveness and contributes to tumour cell adhesion and invasion. Oncotarget 2015, Epub ahead of print 18 March.

Faulkner, S., Dun, M.D., Hondermarck, H. Proteogenomics: emergence and promise. Cell Mol Life Sci. 2015 72(:953-7.

Jobling P, Pundavela J, Oliverira SMR, Roselli S, Walker MM, Hondermarck H. Nerve-cancer cell crosstalk: a novel promoter of tumor progression. Cancer Res. 2015, 75, 1-5.

Pundavela J, Demont Y, Jobling P, Lincz LF, Roselli S, Thorne RF, Bond D, Bradshaw RA, Walker MM, Hondermarck H. ProNGF correlates with Gleason score and is a potential driver of nerve infiltration in prostate cancer. Am J Pathol. 2014. 184, 3156-62.

Fields of Research

CodeDescriptionPercentage
111201Cancer Cell Biology60
110106Medical Biochemistry: Proteins And Peptides (Incl. Medical Proteomics)40

Administrative

Administrative expertise

Head of the Discipline of Medical Biochemistry (Faculty of Health and Medicine).

Teaching

Teaching keywords

  • Cancer biology
  • Cellular and molecular biology

Teaching expertise

Biochemistry, proteomics, cancer biology, bioinformatics.

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Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (24 outputs)

YearCitationAltmetricsLink
2015Faulkner S, Dun MD, Hondermarck H, 'Proteogenomics: emergence and promise.', Cell Mol Life Sci, 72 953-957 (2015)
2015Bradshaw RA, Pundavela J, Biarc J, Chalkley RJ, Burlingame AL, Hondermarck H, 'NGF and ProNGF: Regulation of neuronal and neoplastic responses through receptor signaling', Advances in Biological Regulation, 58 16-27 (2015)
2015Blanckaert V, Kerviel V, Lépinay A, Joubert-Durigneux V, Hondermarck H, Chénais B, 'Docosahexaenoic acid inhibits the invasion of MDA-MB-231 breast cancer cells through upregulation of cytokeratin-1.', Int J Oncol, 46 2649-2655 (2015)
2015Jobling P, Pundavela J, Oliveira SM, Roselli S, Walker MM, Hondermarck H, 'Nerve-Cancer Cell Cross-talk: A Novel Promoter of Tumor Progression.', Cancer Res, 75 1777-1781 (2015)
2015Faulkner S, Dun MD, Hondermarck H, 'Proteogenomics: Emergence and promise', Cellular and Molecular Life Sciences, 72 953-957 (2015)
2015Roselli S, Pundavela J, Demont Y, Faulkner S, Keene S, Attia J, et al., 'Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion.', Oncotarget, 6 10473-10486 (2015)
2014Pundavela J, Demont Y, Jobling P, Lincz LF, Roselli S, Thorne RF, et al., 'ProNGF correlates with Gleason score and is a potential driver of nerve infiltration in prostate cancer', American Journal of Pathology, 184 3156-3162 (2014) [C1]
2014Bradshaw RA, Pundavela J, Biarc J, Chalkley RJ, Burlingame AL, Hondermarck H, 'NGF and ProNGF: Regulation of neuronal and neoplastic responses through receptor signaling', Advances in Biological Regulation, (2014)
2013Bailly F, Toillon R-A, Tomavo O, Jouy N, Hondermarck H, Cotelle P, 'Antiproliferative and apoptotic effects of the oxidative dimerization product of methyl caffeate on human breast cancer cells', BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 23 574-578 (2013) [C1]
2012Demont Y, Corbet C, Page A, Ataman-Onal Y, Choquet-Kastylevsky G, Fliniaux I, et al., 'Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein', Journal of Biological Chemistry, 287 1923-1931 (2012) [C1]
2011Vanhecke E, Adriaenssens E, Verbeke S, Meignan S, Germain E, Berteaux N, et al., 'Brain-derived neurotrophic factor and neurotrophin-4/5 are expressed in breast cancer and can be targeted to inhibit tumor cell survival', Clinical Cancer Research, 17 1741-1752 (2011) [C1]
2011Wilmet J-P, Tastet C, Desruelles E, Ziental-Gelus N, Blanckaert V, Hondermarck H, Le Bourhis X, 'Proteome changes induced by overexpression of the p75 neurotrophin receptor (p75(NTR)) in breast cancer cells', INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY, 55 801-809 (2011) [C1]
2010Le Bourhis X, Romon R, Hondermarck H, 'Role of endothelial progenitor cells in breast cancer angiogenesis: From fundamental research to clinical ramifications', Breast Cancer Research and Treatment, 120 17-24 (2010) [C1]
2010Lagadec C, Romon R, Tastet C, Meignan S, Com E, Page A, et al., 'Ku86 is important for TrkA overexpression-induced breast cancer cell invasion', Proteomics - Clinical Applications, 4 580-590 (2010) [C1]
2010Romon R, Adriaenssens E, Lagadec C, Germain E, Hondermarck H, Le Bourhis X, 'Nerve growth factor promotes breast cancer angiogenesis by activating multiple pathways', Molecular Cancer, 9 (2010) [C1]
2010Verbeke S, Meignan S, Lagadec C, Germain E, Hondermarck H, Adriaenssens E, Le Bourhis X, 'Overexpression of p75NTR increases survival of breast cancer cells through p21waf1 ', Cellular Signalling, 22 1864-1873 (2010) [C1]
2009Lagadec C, Meignan S, Adriaenssens E, Foveau B, Vanhecke E, Romon R, et al., 'TrkA overexpression enhances growth and metastasis of breast cancer cells', Oncogene, 28 1960-1970 (2009) [C1]
2009Joubel A, Chalkley RJ, Medzihradszky KF, Hondermarck H, Burlingame AL, 'Identification of new p53 acetylation sites in COS-1 cells', Molecular and Cellular Proteomics, 8 1167-1173 (2009) [C1]
2009Strande V, Canelle L, Tastet C, Burlet-Schiltz O, Monsarrat B, Hondermarck H, 'The proteome of the human breast cancer cell line MDA-MB-231: Analysis by LTQ-Orbitrap mass spectrometry', Proteomics - Clinical Applications, 3 41-50 (2009) [C1]
2009Collins BC, Lau TYK, O'Connor DP, Hondermarck H, 'Cancer proteomics - An evolving battlefield: Conference on cancer proteomics 2009: Mechanistic insights, technological advances & molecular medicine', EMBO Reports, 10 1202-1205 (2009) [E3]
2008Hondermarck H, Tastet C, Yazidi-Belkoura IE, Toillon R-A, Bourhis XL, 'Proteomics of breast cancer: The quest for markers and therapeutic targets', Journal of Proteome Research, 7 1403-1411 (2008) [C1]
2008Adriaenssens E, Vanhecke E, Saule P, Mougel A, Page A, Romon R, et al., 'Nerve growth factor is a potential therapeutic target in breast cancer', Cancer Research, 68 346-351 (2008) [C1]
2008Berteaux N, Aptel N, Cathala G, Genton C, Coll J, Daccache A, et al., 'A novel H19 antisense RNA overexpressed in breast cancer contributes to paternal IGF2 expression', Molecular and Cellular Biology, 28 6731-6745 (2008) [C1]
2008Hondermarck H, 'Nerve Growth Factor: The Dark Side of the Icon', The American Journal of Pathology, 172 865-867 (2008) [C3]
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Review (1 outputs)

YearCitationAltmetricsLink
2012Hondermarck H, 'Neurotrophins and their receptors in breast cancer', Cytokine & Growth Factor Reviews (2012) [C1]

Conference (6 outputs)

YearCitationAltmetricsLink
2014Dun MD, Chalkley RJ, Keene S, Bradshaw RA, Hondermarck H, 'Proteomics versus Transcriptomics for the Identification of Cancer Biomarkers: the Case of Brain-derived Metastatic Breast Cancer Cells', MOLECULAR & CELLULAR PROTEOMICS (2014) [E3]

Author URL

Co-authors: MATT DUN

2014Oliveira SMR, Roselli S, Hondermarck H, Jobling P, 'PERIPHERAL NERVES ARE ASSOCIATED WITH SOME OVARIAN TUMOURS', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
2014Shargh VH, Hondermarck H, Liang M, 'MULTIFUNCTIONAL NANOMEDICINES BASED ON ALBUMIN FOR TARGETED BREAST CANCER THERAPY', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
2014Faulkner S, Roselli S, Thorne RF, Scarlett CJ, Walker MM, Hondermarck H, 'PRONGF AND SORTILIN EXPRESSION AND FUNCTION IN PANCREATIC CANCER', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
2013Ahmed AF, De Bock CE, Sontag E, Hondermarck H, Thorne RF, 'The functional role of Fat1 cadherin in the differentiation and proliferation of SH-SY5Y neuroblastoma cells', -, Pokolbin, NSW, Australia (2013) [E3]
2012Roselli SM, Moscato PA, Scott R, Hondermarck H, 'Breast cancer proteomics: Integrating the data with genomics and histology towards clinical applications', 18th Proteomics Symposium. Delegate Handbook, Lorne, Vic (2012) [E3]
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Grants and Funding

Summary

Number of grants10
Total funding$1,158,404

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (2 grants)

High Throughput Image Capture Platform for Translational Cancer Research$282,614
Funding Body: Cancer Institute NSW

Project Team
Conjoint Professor Stephen Ackland, Professor Rodney Scott, Professor John Forbes, Professor Xu Dong Zhang, Professor Marjorie Walker, Professor Hubert Hondermarck, Doctor Craig Gedye, Doctor Rick Thorne, Mr Loui Rassam, Doctor Stephen Braye
SchemeRole
Research Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$282,61420142014
GNo:G1400626

Prostate Cancer: A new protein for improving diagnosis, prognosis and treatment$20,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Severine Roselli, Professor Hubert Hondermarck
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020142014
GNo:G1401520

2013 (4 grants)

Triple Quadrupole Mass Spectrometer with nano-infusion for targeted protein quantification$300,000
Funding Body: University of Newcastle

Project Team
Doctor Mark Baker, Laureate Professor John Aitken, Conjoint Professor Bogdan Dlugogorski, Professor Hubert Hondermarck
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$300,00020132013
GNo:G1200137

Leica TP 1020 Automatic Tissue Processor for histology applications$35,000
Funding Body: NHMRC (National Health & Medical Research Council)

Ultra-Low Temperature Cryogenic Freezer$24,596
Funding Body: NHMRC (National Health & Medical Research Council)

12th World Congress of the Human Proteome Organization (HUPO), Yokohama Japan, 14 - 18 September 2013$1,500
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Professor Hubert Hondermarck
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,50020132013
GNo:G1300864

2012 (4 grants)

The Hunter Cancer Biobank (HCB): Maximising community value through validation, annotation and distribution throughout NSW$292,300
Funding Body: Cancer Institute NSW

Project Team
Professor John Forbes, Conjoint Professor Stephen Ackland, Professor Rodney Scott, Conjoint Associate Professor Barbara Young, Professor Hubert Hondermarck, Emeritus Professor Leonie Ashman, Professor Xu Dong Zhang, Doctor Kelly Kiejda, Doctor Nikki Verrills, Doctor Jennette Sakoff, Ms Janine Lombard, Doctor Jude Weidenhofer, Doctor Pradeep Tanwar
SchemeRole
Research Infrastructure GrantsInvestigator
Total AmountFunding StartFunding Finish
$292,30020122014
GNo:G1200798

High-Resolution Isoelectric Phosphoprotein Signalling System for Signalling Research, Biomarker Validation and Drug Development – Equipment Grant$143,394
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Rick Thorne, Professor Xu Dong Zhang, Professor Hubert Hondermarck, Conjoint Professor Stephen Ackland, Doctor Lisa Lincz, Doctor Jennette Sakoff, Emeritus Professor Leonie Ashman
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$143,39420122012
GNo:G1200555

Microscopic illumination system for advanced fluorescent protein technology$34,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Rick Thorne, Professor Xu Dong Zhang, Conjoint Associate Professor Murray Cairns, Doctor Nikki Verrills, Doctor Charles De Bock, Doctor Jude Weidenhofer, Doctor Severine Roselli, Doctor Kathryn Skelding, Emeritus Professor Leonie Ashman, Professor Hubert Hondermarck
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$34,00020122012
GNo:G1100983

Does Ubiquitination control the altered expression of tetraspanin proteins in Breast Cancer?$25,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jude Weidenhofer, Emeritus Professor Leonie Ashman, Professor Hubert Hondermarck
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$25,00020122012
GNo:G1200169
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Research Supervision

Number of current supervisions10
Total current UoN PhD EFTSL2.65

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20152019PhD (Medical Biochemistry)Co-SupervisorBiomarkers for Circulating Ovarian Cancer Cells: A Prognostic and Therapeutic Approach
20142018PhD (Medical Biochemistry)Co-SupervisorTo Investigate the Interaction of Bone Marrow Derived Endothelial Progenitor Cells (EPCs) with Ovarian Cancer Stem Cells (CSCs) in Tumor Angiogenesis Invasion
20142018PhD (Medical Biochemistry)Co-SupervisorWNT Signaling in Uterine Cancer
20142018PhD (Medical Biochemistry)Principal SupervisorProNGF in Pancreatic Cancer
20142016PhD (Human Physiology)Co-SupervisorThe Nerve-Cancer Connection: Tumour Innervation and Trophic Factors in Ovarian Cancer
20132017PhD (Medical Biochemistry)Co-SupervisorRole of Wnt Signalling in Endometrial Homeostasis and Cancer
20132017PhD (Pharmacy)Co-SupervisorMultifunctional Nanomedicines Based on Albumin for Targeted Cancer Therapy
20132017PhD (Medical Biochemistry)Co-SupervisorRole of Wnt Signalling in Testicular Morphogenesis and Carcinogenesis
20122015PhD (Medical Biochemistry)Principal SupervisorProNGF/NGF and Nerve Infiltration in Prostate and Breast Cancer
20112015PhD (Medical Biochemistry)Co-SupervisorRole of FAT1 Cadherin in Neuronal Differentiation
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Professor Hubert Hondermarck

Work Phone(02) 4921 8830
Fax(02) 4921 7903
Email
PositionProfessor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaMedical Biochemistry
Office
LS3-35,
Life Sciences,
Callaghan
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/hubert-hondermarck