Staff Profile

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Career Summary

Biography

I undertook my Bachelor of Science (Hons I) studies at the University of Newcastle. I then completed my PhD through the University of Sydney, Faculty of Medicine where I established a novel proteomic initiative with the specific aim of using proteomics as a tool to answer clinically relevant questions. Using this approach I identified unique markers of pancreatic and bile duct cancer by creating powerful new diagnostic models for the improved diagnosis of pancreatico-biliary malignancies. I then continued my interest in pancreatic cancer research by joining the Pancreatic Cancer Research Group at the Garvan Institute of Medical Research in 2007. In my early post-doctoral years, I was awarded an NHMRC Postdoctoral Training Fellowship (Peter Doherty) and was funded as a Cancer Institute NSW Early Career Development Fellow at the Garvan Institute. My research interests primarily focussed on signalling pathways in pancreatic cancer to identify novel therapeutic and chemopreventative strategies, as well as defining the role of bone marrow derived cells in the development of the normal pancreas, pancreatic injury and regeneration, and pancreatic cancer. Recognition of these contributions included a feature article in the CINSW Cancer Research Achievement Report 2008; A celebration of the outstanding contributions made to cancer research in NSW. I am also is a Cancer Institute NSW Career Development Fellow investigating novel therapeutic approaches to pancreatic cancer, and was awarding the Cancer Research Network Innovation Award (Sydney Cancer Conference 2010). I am also investigating the personalised treatment of metastatic pancreatic cancer based on genomic sequence data acquired through the Australian Pancreatic Cancer Genome Initiative, as part of the International Cancer Genome Consortium. I moved to the University of Newcastle in early 2012 to take a position within the School of Environmental and Life Sciences,and am now driving a research program investigating aberrations in nutrient-gene interactions to define clinically relevant phenotypes of pancreatic cancer, as well as examining the efficacy of bioactive compounds as novel therapeutics in the treatment of pancreatic cancer.

Qualifications

  • PhD, University of Sydney, 06/12/2007
  • Bachelor of Science (Honours), University of Newcastle, 11/07/2000
  • Bachelor of Science, University of Newcastle, 05/07/1999

Research

Research keywords

  • Carcinogenesis
  • Metastases
  • Mouse Models
  • Novel Therapeutics
  • Pancreatic Cancer

Research expertise

My research interests have primarily focused on signalling pathways in pancreatic cancer to identify novel therapeutic and chemopreventative strategies, as well as defining the role of bone marrow derived cells in the development of the normal pancreas, pancreatic injury and regeneration, and pancreatic cancer. I am also investigating novel therapeutic approaches to pancreatic cancer in addition to investigating personalised treatment of metastatic pancreatic cancer based on genomic sequence data acquired through the Australian Pancreatic Cancer Genome Initiative, as part of the International Cancer Genome Consortium (ICGC). Upon my move to the University of Newcastle, School of Environmental and Life Sciences, I have been investigating aberrations in nutrient-gene interactions to define clinically relevant phenotypes of pancreatic cancer, as well as examining the efficacy of bioactive compounds as novel therapeutics in the treatment of pancreatic cancer.

Languages

  • English

Fields of Research

CodeDescriptionPercentage
111200Oncology And Carcinogenesis60
111201Cancer Cell Biology20
111204Cancer Therapy (Excl. Chemotherapy And Radiation Therapy)20

Collaboration

I am an Associate Investigator for the Australian Pancreatic Cancer Network, based at the Garvan Institute of Medical Research, which provides direct links to the clinical management of patients facilitating rapid translation of scientific discoveries to patient care, providing a unique opportunity for translational research efforts in pancreatic cancer in Australia. I am also contributing to the Australian Pancreatic Cancer Genome Initiative (APGI), which aims to sequence ~400 individual pancreatic cancers as part of the International Cancer Genome Consortium (ICGC). I have been awarded project grant funding through the Priority-driven Collaborative Cancer Research Scheme, co-funded by Cancer Australia and the Cure Cancer Australia Foundation (CIA; 2012-1013). I am also a Co-Investigator on a successful NHMRC program grant ($11,128,320; 2009-2013), and a Co-Chief Investigator on successful project grants through the NHMRC (CI-B; 2011-2013) and The Cancer Council NSW (CI-C; 2010-2012) in collaboration with Dr Tao Liu at the Children’s Cancer Institute Australia.

Teaching

Teaching keywords

  • Biochemistry
  • Microbiology
  • Research Methods

Teaching expertise

I have been involved in coordinating and teaching core courses for the Bachelor of Food Science and Human Nutrition Program, in particular BIOL2011 - Fundamentals of Biology and Biochemistry; and FSHN2100 - Microbiology, Food Safety and Immunology.

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Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Chapter (1 outputs)

YearCitationAltmetricsLink
2013Vuong QV, Scarlett CJ, Roach PD, 'Green tea and pancreatic cancer chemoprevention', Green Tea: Varieties, Production and Health Benefits, Nova Science Publishers, New York 75-90 (2013) [B1]

Co-authors: Paul Roach

Journal article (42 outputs)

YearCitationAltmetricsLink
2014Colyin EK, Scarlett CJ, 'A historical perspective of pancreatic cancer mouse models', SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 27 96-105 (2014) [C1]
2014Sun Y, Liu PY, Scarlett CJ, Malyukova A, Liu B, Marshall GM, et al., 'Histone deacetylase 5 blocks neuroblastoma cell differentiation by forming a protein complex with N-Myc and repressing target gene transcription', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 34 S132-S132 (2014)
2014Morran DC, Mrowinska A, Kalna G, Karim SA, Au AYM, Pajak MZ, et al., 'Targeting mTOR dependency in pancreatic cancer', Gut, (2014)
2014Vuong QV, Hirun S, Chuen TLK, Goldsmith CD, Bowyer MC, Chalmers AC, et al., 'Physicochemical composition, antioxidant and anti-proliferative capacity of a lilly pilly (Syzygium paniculatum) extract', Journal of Herbal Medicine, 4 134-140 (2014)
2014Hirun S, Utama-ang N, Vuong QV, Scarlett CJ, 'Investigating the Commercial Microwave Vacuum Drying Conditions on Physicochemical Properties and Radical Scavenging Ability of Thai Green Tea', DRYING TECHNOLOGY, 32 47-54 (2014)
2014Sun Y, Liu PY, Scarlett CJ, Malyukova A, Liu B, Marshall GM, et al., 'Histone deacetylase 5 blocks neuroblastoma cell differentiation by interacting with N-Myc', Oncogene, 33 2987-2994 (2014)
2014Shahbazi J, Scarlett CJ, Norris MD, Liu B, Haber M, Tee AE, et al., 'Histone Deacetylase 2 and N-Myc reduce p53 protein phosphorylation at serine 46 by repressing gene transcription of tumor protein 53-induced nuclear protein 1', ONCOTARGET, 5 4257-4268 (2014)
2014Nagrial AM, Chang DK, Nguyen NQ, Johns AL, Chantrill LA, Humphris JL, et al., 'Adjuvant chemotherapy in elderly patients with pancreatic cancer', British Journal of Cancer, 110 313-319 (2014)
2014Vuong QV, Hirun S, Chuen TL, Goldsmith CD, Murchie S, Bowyer MC, et al., 'Antioxidant and anticancer capacity of saponin-enriched Carica papaya leaf extracts', International Journal of Food Science and Technology, (2014)
2014Vuong QV, Hirun S, Chuen TLK, Bowyer MC, Goldsmith CD, Scarlett CJ, Phillips PA, 'Fruit-derived phenolic compounds and pancreatic cancer: Perspectives from Australian native fruits', Journal of Ethnopharmacology, (2014)
2014Morran DC, Wu J, Jamieson NB, Mrowinska A, Kalna G, Karim SA, et al., 'Targeting mTOR dependency in pancreatic cancer', Gut, 63 1481-1489 (2014)
2013Liu PY, Xu N, Malyukova A, Scarlett CJ, Sun YT, Zhang XD, et al., 'The histone deacetylase SIRT2 stabilizes Myc oncoproteins', CELL DEATH AND DIFFERENTIATION, 20 503-514 (2013) [C1]
2013Scarlett CJ, 'Contribution of bone marrow derived cells to the pancreatic tumor microenvironment', Frontiers in Physiology, 4 (2013) [C1]
2013Chang DK, Jamieson NB, Johns AL, Scarlett CJ, Pajic M, Chou A, et al., 'Histomolecular Phenotypes and Outcome in Adenocarcinoma of the Ampulla of Vater', JOURNAL OF CLINICAL ONCOLOGY, 31 1348-1356 (2013) [C1]
2013Vuong QV, Hirun S, Roach PD, Bowyer MC, Phillips PA, Scarlett CJ, 'Effect of extraction conditions on total phenolic compounds and antioxidant activities of Carica papaya leaf aqueous extracts', JOURNAL OF HERBAL MEDICINE, 3 104-111 (2013) [C1]
2013Sun Y, Liu PY, Malyukova A, MacKenzie KL, Scarlett CJ, Liu B, et al., 'Histone deacetylase 5 blocks neuroblastoma cell differentiation by interacting with N-Myc', Oncogene, (2013)
2013Vuong QV, Hirun S, Chuen TLK, Goldsmith CD, Bowyer MC, Scarlett CJ, et al., 'Physicochemical composition, antioxidant and anti-proliferative capacity of a lilly pilly (Syzygium paniculatum) extract', Journal of Herbal Medicine, (2013)
2012Biankin AV, Waddell N, Kassahn KS, Gingras M-C, Muthuswamy LB, Johns AL, et al., 'Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes', Nature, 491 399-405 (2012) [C1]
2012Das A, Musgrove EA, Sutherland RL, Biankin AV, Humphris JL, Chang DK, et al., 'The prognostic and predictive value of serum CA19.9 in pancreatic cancer', Annals of Oncology, 23 1713-1722 (2012) [C1]
2011Chong JJH, Chandrakanthan V, Xaymardan M, Asli NS, Li J, Ahmed I, et al., 'Adult cardiac-resident MSC-like stem cells with a proepicardial origin', Cell Stem Cell, 9 527-540 (2011) [C1]
2011Nguyen NQ, Johns AL, Gill AJ, Ring N, Chang DK, Clarkson A, et al., 'Clinical and immunohistochemical features of 34 solid pseudopapillary tumors of the pancreas', Journal of Gastroenterology and Hepatology, 26 267-274 (2011) [C1]
2011Scarlett CJ, Colvin EK, Pinese M, Chang DK, Morey AL, Musgrove EA, et al., 'Recruitment and activation of pancreatic stellate cells from the bone marrow in pancreatic cancer: A model of tumor-host interaction', PLoS One, 6 1-8 (2011) [C1]
2011Colvin EK, Susanto JM, Kench JG, Ong VN, Mawson A, Pinese M, et al., 'Retinoid signaling in pancreatic cancer, injury and regeneration', PLoS ONE, 6 e29075 (2011) [C1]
2011Marshall GM, Liu PY, Gherardi S, Scarlett CJ, Bedalov A, Xu N, et al., 'SIRT1 promotes N-Myc oncogenesis through a positive feedback loop involving the effects of MKP3 and ERK on N-Myc protein stability', PLoS Genetics, 7 (2011) [C1]
2011Kwong RA, Scarlett CJ, Kalish LH, Cole IE, Kench JG, Sum EY, et al., 'LMO4 expression in squamous cell carcinoma of the anterior tongue', Histopathology, 58 477-480 (2011) [C3]
2010Xue A, Scarlett CJ, Chung L, Butturini G, Scarpa A, Gandy R, et al., 'Discovery of serum biomarkers for pancreatic adenocarcinoma using proteomic analysis', British Journal of Cancer, 103 391-400 (2010) [C1]
2010Marshall GM, Gherardi S, Xu N, Neiron Z, Trahair T, Scarlett CJ, et al., 'Transcriptional upregulation of histone deacetylase 2 promotes Myc-induced oncogenic effects', Oncogene, 29 5957-5968 (2010) [C1]
2009Chang DK, Johns AL, Merrett ND, Gill AJ, Colvin EK, Scarlett CJ, et al., 'Margin Clearance and Outcome in Resected Pancreatic Cancer', Journal of Clinical Oncology, 27 2855-2862 (2009) [C1]
2009Biankin AV, Kench JG, Colvin EK, Segara D, Scarlett CJ, Nguyen NQ, et al., 'Expression of S100A2 Calcium-Binding Protein Predicts Response to Pancreatectomy for Pancreatic Cancer', Gastroenterology, 137 558-568 (2009) [C1]
2009Pinese M, Scarlett CJ, Kench JG, Colvin EK, Segara D, Henshall SM, et al., 'Messina: A novel analysis tool to identify biologically relevant molecules in disease', PLoS One, 4 (2009) [C1]
2008Xue A, Scarlett CJ, Jackson CJ, Allen BJ, Smith RC, 'Prognostic significance of growth factors and the urokinase-type plasminogen activator system in pancreatic ductal adenocarcinoma', Pancreas, 36 160-167 (2008) [C1]
2008Kuo SCL, Gananadha S, Scarlett CJ, Gill A, Smith RC, 'Sporadic pancreatic polypeptide secreting tumors (PPomas) of the pancreas', World Journal of Surgery, 32 1815-1822 (2008) [C1]
2008Murphy NC, Scarlett CJ, Kench JG, Sym EYM, Segara D, Colvin EK, et al., 'Expression of LMO4 and outcome in pancreatic ductal adenocarcinoma', British Journal of Cancer, 98 537-541 (2008) [C1]
2007O'Leary MJ, Xue A, Scarlett CJ, Sevette A, Kee AJ, Smith RC, 'Parenteral versus enteral nutrition: Effect on serum cytokines and the hepatic expression of mRNA of suppressor of cytokine signaling proteins, insulin-like growth factor-1 and the growth hormone receptor in rodent sepsis', CRITICAL CARE, 11 (2007) [C1]
2007Smith R, Xue A, Gill A, Scarlett C, Saxby A, Clarkson A, Hugh T, 'High expression of plasminogen activator inhibitor-2 (PAI-2) is a predictor of improved survival in patients with pancreatic adenocarcinoma', WORLD JOURNAL OF SURGERY, 31 493-503 (2007) [C1]
2007Scarlett CJ, Samra SJ, Xue A, Baxter RC, Smith RC, 'Classification of pancreatic cystic lesions using SELDI-TOF mass spectrometry', ANZ Journal of Surgery, 77 648-653 (2007) [C1]
2006Scarlett CJ, Saxby AJ, Nielsen A, Bell C, Samra JS, Hugh T, et al., 'Proteomic profiling of cholangiocarcinoma: Diagnostic potential of SELDI-TOF MS in malignant bile duct stricture', Hepatology, 44 658-666 (2006) [C1]
2006Scarlett CJ, Smith RC, Saxby A, Nielsen A, Samra JS, Wilson SR, Baxter RC, 'Proteomic Classification of Pancreatic Adenocarcinoma Tissue Using Protein Chip Technology', Gastroenterology, 130 1670-1678 (2006) [C1]
2005Nielsen A, Scarlett CJ, Samra JS, Gill A, Li Y, Allen BJ, Smith RC, 'Significant overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma using real-time quantitative reverse transcription polymerase chain reaction', Journal of Gastroenterology and Hepatology, 20 256-263 (2005) [C1]
2005Saxby AJ, Nielsen A, Scarlett CJ, Clarkson A, Morey A, Gill A, Smith RC, 'Assessment of HER-2 status in pancreatic adenocarcinoma: Correlation of immunohistochemistry, quantitative real-time RT-PCR, and FISH with aneuploidy and survival', American Journal of Surgical Pathology, 29 1125-1134 (2005) [C1]
2004Scarlett CJ, O'Leary MJ, Kee AJ, Nielsen A, Sevette A, Baxter RC, Smith RC, 'A study of parenteral versus enteral nutrition following caecal ligation and puncture in the rat: Influence on survival and tissue protein turnover', Clinical Nutrition, 23 1135-1145 (2004) [C1]
2001Scarlett CJ, Lin M, Aitken RJ, 'Actin polymerisation during morphogenesis of the acrosome as spermatozoa undergo epididymal maturation in the tammar wallaby (Macropus eugenii)', Journal of Anatomy, 198 93-101 (2001) [C1]
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Review (3 outputs)

YearCitationAltmetricsLink
2011Pajic M, Scarlett CJ, Chang DK, Sutherland RL, Biankin AV, 'Preclinical strategies to define predictive biomarkers for therapeutically relevant cancer subtypes', Human Genetics (2011) [D1]
2011Scarlett CJ, Salisbury EL, Biankin AV, Kench J, 'Precursor lesions in pancreatic cancer: Morphological and molecular pathology', Pathology (2011) [D1]
2011Scarlett CJ, Biankin A, 'S100A2 (S100 calcium binding protein A2; 1q21)', Atlas of Genetics and Cytogenetics in Oncology and Haematology (2011) [D2]

Conference (1 outputs)

YearCitationAltmetricsLink
2012Chantrill L, Gill A, Johns A, Wu J, Scarlett CJ, Biankin A, Australian Pancreatic Cancer Genome Initiative, 'The outliers of pancreatic cancer: Preliminary data for timeless expression as a prognostic biomarker', Asia-Pacific Journal of Clinical Oncology: Special Issue: Medical Oncology Group of Australia Incorporated Annual Scientific Meeting, Program and Abstracts: Targeting Cancer from Diagnosis to Cure, Melbourne, Vic (2012) [E3]
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Grants and Funding

Summary

Number of grants14
Total funding$2,760,756

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (1 grants)

2013 Vice Chancellor's Award for Research Excellence - Regional$2,000
Funding Body: University of Newcastle

Project Team
Doctor Christopher Scarlett
SchemeRole
Award for Research ExcellenceChief Investigator
Total AmountFunding StartFunding Finish
$2,00020142014
GNo:G1301445

2013 (3 grants)

Gastro-pancreatic cancer research$20,050
Funding Body: Terrigal Trotters Inc. Running Club

Project Team
Doctor Christopher Scarlett
SchemeRole
Bay to Bay Running FestivalChief Investigator
Total AmountFunding StartFunding Finish
$20,05020132015
GNo:G1301010

Extraction and identification of cytotoxic compounds from Australian sea sponges as novel therapeutic agents for pancreatic cancer.$14,749
Funding Body: University of Newcastle - Faculty of Science & IT

Project Team
Doctor Christopher Scarlett, Doctor Quan Vuong
SchemeRole
Strategic Small GrantChief Investigator
Total AmountFunding StartFunding Finish
$14,74920132013
GNo:G1401071

Faculty Visiting Fellowship 2013$7,504
Funding Body: University of Newcastle - Faculty of Science & IT

Project Team
Doctor Christopher Scarlett
SchemeRole
Visiting FellowshipChief Investigator
Total AmountFunding StartFunding Finish
$7,50420132013
GNo:G1401145

2012 (5 grants)

The therapeutic potential of targeting S100A2 calcium-binding protein in pancreatic cancer$177,451
Funding Body: Cancer Australia

Project Team
Doctor Christopher Scarlett
SchemeRole
Priority-driven Collaborative Cancer Research SchemeChief Investigator
Total AmountFunding StartFunding Finish
$177,45120122014
GNo:G1200404

The therapeutic potential of targeting S100A2 calcium-binding protein in pancreatic cancer$177,450
Funding Body: Cure Cancer Australia Foundation

SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$177,45020122013
GNo:176109815

Novel Targeted Therapies for Pancreatic Cancer$149,877
Funding Body: Cancer Institute NSW

Project Team
Doctor Christopher Scarlett
SchemeRole
Career Development FellowshipChief Investigator
Total AmountFunding StartFunding Finish
$149,87720122012
GNo:G1200531

Establishment of a pancreatic cancer research program for screening the activity and efficacy of natural bioactive compounds$74,048
Funding Body: Ramaciotti Foundations

Project Team
Doctor Christopher Scarlett
SchemeRole
Establishment GrantChief Investigator
Total AmountFunding StartFunding Finish
$74,04820122013
GNo:G1200739

Project support to develop pancreatic cancer research within the School$5,000
Funding Body: University of Newcastle

Project Team
Doctor Christopher Scarlett
SchemeRole
New Staff GrantChief Investigator
Total AmountFunding StartFunding Finish
$5,00020122012
GNo:G1200559

2011 (1 grants)

Targeting histone deacetylases for the therapy of Myc-induced malignancies$344,208
Funding Body: NHMRC (National Health & Medical Research Council)

SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$344,20820112013
GNo:176109596

2010 (2 grants)

Novel Targeted Therapies for Pancreatic Cancer$599,681
Funding Body: Cancer Institute NSW

SchemeRole
Career Development FellowshipChief Investigator
Total AmountFunding StartFunding Finish
$599,68120102012
GNo:176109650

Targeting Myc onco-protein degradation for the treatment of Myc-induced malignancies$319,500
Funding Body: Cancer Council NSW

SchemeRole
Research GrantInvestigator
Total AmountFunding StartFunding Finish
$319,50020102012
GNo:176109658

2009 (1 grants)

Continuing infrastructure support for the ACRF Genomics Facility$330,000
Funding Body: Cancer Institute NSW

SchemeRole
Infrastructure GrantsInvestigator
Total AmountFunding StartFunding Finish
$330,00020092011
GNo:176109666

2007 (1 grants)

Adult Haematopoietic Stem Cells in The Evolution of Pancreatic Cancer$539,238
Funding Body: Cancer Institute NSW

SchemeRole
Early Career FellowshipChief Investigator
Total AmountFunding StartFunding Finish
$539,23820072009
GNo:176109676
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Research Supervision

Number of current supervisions5
Total current UoN PhD EFTSL2.4

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20142018PhD (Food Science)Principal SupervisorEvaluation of Edible Coating Application on Different Fruits
20142018PhD (Food Science)Principal SupervisorNatural Products as a Source of Anti-cancer Agents for Gastro-pancreatic Malignancies
20142018PhD (Food Science)Principal SupervisorResearch on Bioactive Compounds, Antioxidant and Antigastric-Pancreatic Cancer Capacity of Two Plants Phyllanthus Amarus and Paramignya Trimera
20142018PhD (Food Science)Principal SupervisorBioactive Compounds Derived from Australia Native Plants Melaleuca alternifolia, Backhousia citriodora and Eucalyptus Globulus as the Sources of Anti-Cancer Agents for Gastro-Pancreatic Malignancies.
20132017PhD (Food Science)Principal SupervisorOlive Waste Products as a Source of Phenolic Compounds with Chemotherapeutic and Chemopreventative Efficacy Against Pancreatic Cancer
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Dr Christopher Scarlett

Work Phone(02) 4348 4680
Email
PositionSenior Lecturer
Food Science & Human Nutrition
School of Environmental and Life Sciences
Faculty of Science and Information Technology
The University of Newcastle, Australia
Focus AreaApplied Sciences
Office
SO E1.46,
Science Offices,
Ourimbah
10 Chittaway Road
Ourimbah NSW 2258
Australia
URL:www.newcastle.edu.au/profile/c-scarlett