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Emeritus Professor Leonie Ashman

Conjoint Professor

School of Biomedical Sciences and Pharmacy (Medical Biochemistry)

Career Summary

Biography

Professor Ashman is a NHMRC Principal Research Fellow and Gladys Brawn Professorial Fellow. She came to the University of Newcastle in 2002 from the Hanson Centre for Cancer Research and the University of Adelaide. In her career spanning 35 years she has published 150 papers in refereed international journals and conference proceedings. Career highlights include identification at the protein level of the receptor tyrosine kinase c-KIT, publication of the first monoclonal antibody to it, and the first description of c-KIT expression by haemopoietic progenitor cells in bone marrow. She has an ongoing interest in the role of mutant c-KIT in acute myeloid leukaemia and other cancers and in new drugs that target this receptor. Prof Ashman's group also identified a novel tetraspanin protein, CD151, cloned the gene, and generated the first CD151 knock-out mice. Work in this and other laboratories has shown that the CD151 protein modifies cell adhesion and migration and plays an important role in the spread (metastasis) of cancer.

Research Expertise

I was trained as a biochemist but worked for many years in immunology. In now consider myself as a cell and molecular biologist. The underlying theme of my research has always been cancer, its cellular and molecular biology and development of novel approaches to diagnosis and treatment. Major themes have been haemopoiesis and leukaemia, regulation of cellular behaviour by cell surface receptors, cellular signalling and development of novel targetted therapeutics.

Teaching Expertise
While I have always been employed in "Research Only" positions I have contributed extensively to teaching both at the University of Adelaide and the University of Newcastle. Currently I teach into the B Biomed Sci program in my areas of research expertise (Cancer biology and novel drug development).

Administrative Expertise
Initiated and coordinated B Health Sci (Hons) program in Experimental Medicine at Adelaide University, Member, Graduate Studies Committee and Board of Research Education and Development at Adelaide University Elected Staff Representative, Hanson Centre Executive Member, Hanson Institute Strategic Advisory Committee Member, NHMRC Research Fellowships Advisory Panel, 2001, 2002. Member NHMRC Grant Review panel, 2005, 2006. At University of Newcastle: Member, Faculty of Health Research Management Committee (2002, 2003). Research Portfolio Committee, 2004 (casual vacancy) Member of multiple appointments committess and grant review panels. 


Qualifications

  • PhD, University of Adelaide
  • Bachelor of Science (Honours), Flinders University

Keywords

  • Cancer Biology
  • Cell and Molecular biology of cancer

Fields of Research

CodeDescriptionPercentage
110199Medical Biochemistry and Metabolomics not elsewhere classified10
111299Oncology and Carcinogenesis not elsewhere classified30
060199Biochemistry and Cell Biology not elsewhere classified60

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2011 - 31/12/2011Senior Brawn Research FellowUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

DatesTitleOrganisation / Department
1/01/2006 - 1/12/2011FellowUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/2004 - 1/12/2008Joint ConvenorHunter Medical Research Institute International Conferences on Translational Cancer Research
Australia
1/04/1993 - 1/12/2001Affiliate Associate ProfessorThe University of Adelaide
Department of Medicine
Australia
1/10/1992 - 1/12/2001NHMRC Principal Research Fellow
Haematology
Institute of Medical and Veterinary Science, Adelaide
Hanson Centre for Cancer Research
Australia

Membership

DatesTitleOrganisation / Department
1/01/2005 - 1/12/2006Member - Grant Review Panel - Cell BiologyNHMRC (National Health & Medical Research Council)
Australia
1/01/2001 - 1/12/2002Member - Research Fellowship Advisory Panel ANHMRC (National Health & Medical Research Council)
Australia

Invitations

Participant

YearTitle / Rationale
2004Summer Research Conference: tetraspanins
Organisation: Federation of American Societies of Experimental Biology Description: I was invited speaker and session chair at all three biennial conferences in this field (2002, 2004, 2006). This is the most important international conference in this specialist field.
2001Glivec Solid Tumour Advisory Board
Organisation: Novartis Pharma Description: Expert consultant/ member of this select panel to adivse on the cell biology and potential clinical applications of an new protein kinase inhibitory drug.
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

YearCitationAltmetricsLink
2013Ashman LK, Zoller M, 'Tetraspanins in Cancer', Tetraspanins, Springer, Dordrecht 257-298 (2013) [B1]
DOI10.1007/978-94-007-6070-7_11Author URL

Journal article (186 outputs)

YearCitationAltmetricsLink
2014Mashkani B, Griffith R, Ashman L, 'Differences in growth promotion, drug response and intracellular protein trafficking of FLT3 mutants', Iranian Journal of Basic Medical Sciences, 17 867-873 (2014) [C1]
Author URL
2014Roselli S, Kahl RGS, Copeland BT, Naylor MJ, Weidenhofer J, Muller WJ, Ashman LK, 'Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model', BMC Cancer, 14 (2014) [C1]

Background: Tetraspanins are transmembrane proteins that serve as scaffolds for multiprotein complexes containing, for example, integrins, growth factor receptors and matrix metal... [more]

Background: Tetraspanins are transmembrane proteins that serve as scaffolds for multiprotein complexes containing, for example, integrins, growth factor receptors and matrix metalloproteases, and modify their functions in cell adhesion, migration and transmembrane signaling. CD151 is part of the tetraspanin family and it forms tight complexes with ß1 and ß4 integrins, both of which have been shown to be required for tumorigenesis and/or metastasis in transgenic mouse models of breast cancer. High levels of the tetraspanin CD151 have been linked to poor patient outcome in several human cancers including breast cancer. In addition, CD151 has been implicated as a promoter of tumor angiogenesis and metastasis in various model systems.Methods: Here we investigated the effect of Cd151 deletion on mammary tumorigenesis by crossing Cd151-deficient mice with a spontaneously metastasising transgenic model of breast cancer induced by the polyoma middle T antigen (PyMT) driven by the murine mammary tumor virus promoter (MMTV).Results: Cd151 deletion did not affect the normal development and differentiation of the mammary gland. While there was a trend towards delayed tumor onset in Cd151 -/- PyMT mice compared to Cd151 +/+ PyMT littermate controls, this result was only approaching significance (Log-rank test P-value =0.0536). Interestingly, Cd151 deletion resulted in significantly reduced numbers and size of primary tumors but did not appear to affect the number or size of metastases in the MMTV/PyMT mice. Intriguingly, no differences in the expression of markers of cell proliferation, apoptosis and blood vessel density was observed in the primary tumors.Conclusion: The findings from this study provide additional evidence that CD151 acts to enhance tumor formation initiated by a range of oncogenes and strongly support its relevance as a potential therapeutic target to delay breast cancer progression. © 2014 Roselli et al.; licensee BioMed Central Ltd.

DOI10.1186/1471-2407-14-509
Co-authorsJudith Weidenhofer
2013Copeland BT, Bowman MJ, Boucheix C, Ashman LK, 'Knockout of the tetraspanin Cd9 in the TRAMP model of de novo prostate cancer increases spontaneous metastases in an organ-specific manner', International Journal of Cancer, 133 1803-1812 (2013) [C1]

Prostate cancer is an extremely heterogeneous disease; patients that do progress to late-stage metastatic prostate cancer have limited treatment options, mostly palliative. Molecu... [more]

Prostate cancer is an extremely heterogeneous disease; patients that do progress to late-stage metastatic prostate cancer have limited treatment options, mostly palliative. Molecules involved in the metastatic cascade may prove beneficial in stratifying patients to assign appropriate treatment modalities and may also prove to be therapeutic antimetastatic targets. The tetraspanin group of molecules are integral membrane proteins that associate with motility-related proteins such as integrins. Clinical studies have mostly shown that reduced expression levels of the tetraspanin CD9 are correlated with tumour progression in a range of cancers. Furthermore, functional studies have shown CD9 to be involved in cell motility and adhesion and that it may influence metastasis. The effects of endogenous CD9 on prostate cancer initiation and progression were analysed by crossing a Cd9-/- (KO) murine model with a model of de novo developing and spontaneously metastasising prostate cancer, namely the transgenic adenocarcinoma of mouse prostate model. Our study demonstrates for the first time that ablation of Cd9 had no detectable effect on de novo primary tumour onset, but did significantly increase metastasis to the liver but not the lungs. What's new? The ability to distinguish between prostate tumors that are more or less likely to spread could facilitate decisions regarding treatment options for patients. A promising marker for such distinction is the tetraspanin protein CD9, which in experimental studies has been linked to metastasis. Here, Cd9 genetic ablation in the well-characterized transgenic adenocarcinoma of mouse prostate (TRAMP) model reveals an association between loss of Cd9 expression and increased incidence of metastases to the liver but not the lung. In contrast, Cd9 ablation did not affect primary prostate tumor initiation. The findings suggest that Cd9 acts as a suppressor of metastasis. Copyright © 2013 UICC.

DOI10.1002/ijc.28204
CitationsScopus - 5Web of Science - 3
2013Ashman LK, 'Renal disease as a potential compounding factor in carcinogenesis experiments with Cd151-null mice', ONCOGENE, 32 4457-4457 (2013) [C3]
DOI10.1038/onc.2013.73Author URL
CitationsScopus - 1Web of Science - 1
2013Mashkani B, Odell AF, Byrnes EM, Griffith R, Ashman LK, 'Expression of biologically active human colony stimulating factor-1 in Pichia pastoris', Protein Expression and Purification, 88 93-97 (2013) [C1]
DOI10.1016/j.pep.2012.11.017Author URL
CitationsScopus - 1Web of Science - 1
2013Ashman LK, Griffith R, 'Therapeutic targeting of c-KIT in cancer', EXPERT OPINION ON INVESTIGATIONAL DRUGS, 22 103-115 (2013) [C1]
DOI10.1517/13543784.2013.740010Author URL
CitationsScopus - 24Web of Science - 25
2013Copeland BT, Bowman MJ, Ashman LK, 'Genetic Ablation of the Tetraspanin CD151 Reduces Spontaneous Metastatic Spread of Prostate Cancer in the TRAMP Model', MOLECULAR CANCER RESEARCH, 11 95-105 (2013) [C1]
DOI10.1158/1541-7786.MCR-12-0468Author URL
CitationsScopus - 10Web of Science - 11
2011Ashman LK, 'Cell line models identify different sensitivity of mutant forms of c-KIT to kinase inhibitory drugs and predict the response of patients to therapy', Molecular Cancer Therapeutics, 10 2032-2033 (2011) [C3]
DOI10.1158/1535-7163.MCT-11-0706
2011Vilain RE, Dudding TE, Braye SG, Groombridge C, Meldrum C, Spigelman AD, et al., 'Can a familial gastrointestinal tumour syndrome be allelic with Waardenburg syndrome?', Clinical Genetics, 79 554-560 (2011) [C3]
DOI10.1111/j.1399-0004.2010.01489.x
CitationsScopus - 4Web of Science - 2
Co-authorsStephen Ackland, Rodney Scott
2010Roberts KG, Smith AM, McDougall FK, Carpenter HC, Horan MP, Neviani P, et al., 'Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers', Cancer Research, 70 5438-5447 (2010) [C1]
DOI10.1158/0008-5472.CAN-09-2544
CitationsScopus - 56Web of Science - 52
Co-authorsNikki Verrills, Alistair Sim
2010Mashkani B, Griffith R, Ashman LK, 'Colony stimulating factor-1 receptor as a target for small molecule inhibitors', Bioorganic & Medicinal Chemistry, 18 1789-1797 (2010) [C1]
DOI10.1016/j.bmc.2010.01.056
CitationsScopus - 14Web of Science - 13
2010Ang J, Fang B-L, Ashman LK, Frauman AG, 'The migration and invasion of human prostate cancer cell lines involves CD151 expression', Oncology Reports, 24 1593-1597 (2010) [C1]
DOI10.3892/or_00001022
CitationsScopus - 11Web of Science - 12
2009Orlowski E, Chand R, Yip J, Wong C, Goschnick MW, Wright MD, et al., 'A platelet tetraspanin superfamily member, CD151, is required for regulation of thrombus growth and stability in vivo', Journal of Thrombosis and Haemostasis, 7 2074-2084 (2009) [C1]
DOI10.1111/j.1538-7836.2009.03612.x
CitationsScopus - 20Web of Science - 17
2009Weidenhofer JC, Ashman LK, 'CD151 (CD151 molecule (Raph blood group))', Atlas of Genetics and Cytogenetics in Oncology and Haematology, - - (2009) [C1]
Co-authorsJudith Weidenhofer
2009Sheng K-C, Van Spriel AB, Gartlan KH, Sofi M, Apostolopoulos V, Ashman LK, Wright MD, 'Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC', European Journal of Immunology, 39 50-55 (2009) [C1]
DOI10.1002/eji.200838798
CitationsScopus - 26Web of Science - 24
2009Protty MB, Watkins NA, Colombo D, Thomas SG, Heath VL, Herbert JMJ, et al., 'Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains', Biochemical Journal, 417 391-400 (2009) [C1]
DOI10.1042/bj20081126
CitationsScopus - 21Web of Science - 21
2008Baleato R, Guthrie PL, Gubler M-C, Ashman LK, Roselli SM, 'Deletion of Cd151 results in a strain-dependent glomerular disease due to severe alterations of the glomerular basement membrane', American Journal of Pathology, 173 927-937 (2008) [C1]
DOI10.2353/ajpath.2008.071149
CitationsScopus - 51Web of Science - 47
2008Foster RC, Byrnes EM, Meldrum C, Griffith R, Ross G, Upjohn E, et al., 'Association of paediatric mastocytosis with a polymorphism resulting in an amino acid substitution (M541L) in the transmembrane domain of c-KIT', British Journal of Dermatology, 159 1160-1169 (2008) [C1]
DOI10.1111/j.1365-2133.2008.08827.x
CitationsScopus - 26Web of Science - 22
Co-authorsRodney Scott
2008Geary SM, Cowin AJ, Copeland BT, Baleato R, Miyazaki K, Ashman LK, 'The role of the tetraspanin CD151 in primary keratinocyte and fibroblast functions: Implications for wound healing', Experimental Cell Research, 314 2165-2175 (2008) [C1]
DOI10.1016/j.yexcr.2008.04.011
CitationsScopus - 17Web of Science - 15
2008Baldwin G, Novitskaya V, Sadej R, Pochec E, Litynska A, Hartmann C, et al., 'Tetraspanin CD151 regulates glycosylation of alpha 3 beta 1 integrin', Journal of Biological Chemistry, 283 35445-35454 (2008) [C1]
DOI10.1074/jbc.m806394200
CitationsScopus - 31Web of Science - 28
2008Yamada M, Tamura Y, Sanzen N, Sato-Nishiuchi R, Hasegawa H, Ashman LK, et al., 'Probing the interaction of tetraspanin CD151 with integrin alpha 3 beta 1 using a panel of monoclonal antibodies with distinct reactivities toward the CD151-integrin alpha 3 beta 1 complex', Biochemical Journal, 415 417-427 (2008) [C1]
DOI10.1042/bj20071625
CitationsScopus - 10Web of Science - 10
2007Young SM, Cambareri AC, Odell AF, Geary SM, Ashman LK, 'Early myeloid cells expressing c-KIT isoforms differ in signal transduction, survival and chemotactic responses to Stem Cell Factor', Cellular Signalling, 19 2572-2581 (2007) [C1]
DOI10.1016/j.cellsig.2007.08.004
CitationsScopus - 9Web of Science - 10
2007Roberts KG, Odell AF, Byrnes EM, Baleato R, Griffith R, Lyons AB, Ashman LK, 'Resistance to c-KIT kinase inhibitors conferred by V654A mutation', Molecular Cancer Therapeutics, 6 1159-1166 (2007) [C1]
DOI10.1158/1535-7163.mct-06-0641
CitationsScopus - 47Web of Science - 46
2006Cowin AJ, Adams D, Geary SM, Wright MD, Jones JCR, Ashman LK, 'Wound healing is defective in mice lacking tetraspanin CD151', Journal of Investigative Dermatology, 126 680-689 (2006) [C1]
DOI10.1038/sj.jid.5700142
CitationsScopus - 54Web of Science - 51
2006Young SM, Cambareri AC, Ashman LK, 'Role of c-KIT expression level and phosphatidylinositol 3-kinase activation in survival and proliferative responses of early myeloid cells', Cellular Signalling, 18 608-620 (2006) [C1]
DOI10.1016/j.cellsig.2005.06.005
CitationsScopus - 13Web of Science - 13
2006Griffith R, Brown MN, McCluskey A, Ashman LK, 'Small molecule inhibitors of protein kinases in cancer - How to overcome resistance', Mini-Reviews in Medicinal Chemistry, 6 1101-1110 (2006) [C1]
DOI10.2174/138955706778560184
CitationsScopus - 5Web of Science - 4
Co-authorsAdam Mccluskey
2006Winterwood NE, Varzavand A, Meland MN, Ashman LK, Stipp CS, 'A critical role for tetraspanin CD151 in alpha 381 and alpha 684 integrin-dependent tumor cell functions on Laminin-5', Molecular Biology of the Cell, 17 2707-2721 (2006) [C1]
DOI10.1091/mbc.E05-11-1042
CitationsScopus - 81Web of Science - 79
2005Nixon B, Paul JW, Spiller CM, Attwell-Heap AG, Ashman LK, Aitken RJ, 'Evidence for the involvement of PECAM-1 in a receptor mediated signal-transduction pathway regulating capacitation-associated tyrosine phosphorylation in human spermatozoa', Journal of Cell Science, 118 4865-4877 (2005) [C1]
DOI10.1242/jcs.02604
CitationsScopus - 13Web of Science - 13
Co-authorsJohn Aitken, Jonathan Paul, Brett Nixon
2005Ang J, Lijovic M, Frauman AG, Ashman LK, Kan K, 'Low grade primary prostate cancer (vol 13, pg 1717, 2004)', CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 14 553-553 (2005)
Author URL
CitationsWeb of Science - 1
2005Ang J, Lijovic M, Frauman AG, Ashman LK, Kahn K, 'Erratum: CD151 protein expression predicts the clinical outcome of low-grade primary prostate cancer better than histologic grading: A new prognostic indicator? (Cancer Epidemiology Biomarkers and Prevention (November 2004) 13, 11 (1717-1721))', Cancer Epidemiology Biomarkers and Prevention, 14 553-553 (2005)
2005Gesierich S, Paret C, Hildebrand D, Weitz J, Zgraggen K, Schmitz-Winnenthal FH, et al., 'Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: Impact on cell motility', Clinical Cancer Research, 11 2840-2852 (2005) [C1]
DOI10.1158/1078-0432.CCR-04-1935
CitationsScopus - 69Web of Science - 64
2004Lau L-M, Wee JL, Wright MD, Moseley GW, Hogarth PM, Ashman LK, Jackson DE, 'The tetraspanin superfamily member CD151 regulates outside-in integrin alpha IIb Beta 3 signaling and platelet function', Blood, 104 2368-2375 (2004) [C1]
DOI10.1182/blood-2003-12-4430
CitationsWeb of Science - 64
2004Moseley GW, Lau L-M, Sheng K-C, Apostolopoulos V, Stanley EG, Jackson DE, et al., 'Characterization of Mice Lacking the Tetraspanin Superfamily Member CD151', Molecular and Cellular Biology, 24 5978-5988 (2004) [C1]
DOI10.1128/MCB.24.13.5978-5988.2004
CitationsScopus - 106Web of Science - 102
2004Ang J, Lijovic M, Ashman LK, Kan K, Frauman A, 'CD151 Protein Expression Predicts the Clinical Outcome of Low-Grade Primary Prostate Cancer Better than Histologic Grading: A New Prognostic Indicator?', Cancer Epidemiology, Biomarkers & Prevention, 13 1717-1721 (2004) [C1]
CitationsScopus - 70Web of Science - 65
2004Foster RC, Griffith R, Ferrao PT, Ashman LK, 'Molecular basis of the constitutive activity and STI571 resistance of Asp816Val mutant KIT receptor tyrosine kinase', Journal of Molecular Graphics and Modelling, 23 139-152 (2004) [C1]
DOI10.1016/j.jmgm.2004.04.003
CitationsScopus - 35Web of Science - 32
2003Charrin S, Manie S, Billard M, Ashman LK, Gerlier D, Boucheix C, Rubinstein E, 'Multiple levels of interactions within the tetraspanin web', Biochemical and Biophysical Research Communications, 304 107-112 (2003) [C1]
DOI10.1016/S0006-291X(03)00545-X
CitationsWeb of Science - 75
2003Thai LM, Ashman LK, Harbour SN, Hogarth M, Jackson D, 'Physical proximity and functional interplay of PECAM-1 with the Fc receptor FcyRIIa on the platelet plasma membrane', Blood, 102 3637-3645 (2003) [C1]
DOI10.1182/blood-2003-02-0496
CitationsWeb of Science - 23
2003Ferrao PT, Frost MJ, Siah SP, Ashman LK, 'Overexpression of P-glycoprotein in K562 cells does not confer resistance to the growth inhibitory effects of imatinib (STI571) in vitro', Blood, 102 4499-4503 (2003) [C1]
DOI10.1182/blood-2003-01-0083
CitationsScopus - 70Web of Science - 59
2003Voytyuk O, Lennartsson J, Mogi A, Caruana G, Courtneidge S, Ashman LK, Ronnstrand L, 'Src Family Kinases Are Involved in the Differential Signaling from Two Splice Forms of c-Kit', The Journal of Biological Chemistry, 278 9159-9166 (2003) [C1]
DOI10.1074/jbc.M211726200
CitationsScopus - 55Web of Science - 53
2003Chattopadhyay N, Wang Z, Ashman LK, Brady-Kalnay SM, Kreidberg JA, 'Alpha3 beta1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTPu expression and cell-cell adhesion', The Journal of Cell Biology, 163 1351-1362 (2003) [C1]
DOI10.1083/jcb.200306067
CitationsScopus - 96Web of Science - 93
2003Ferrao PT, Gonda T, Ashman LK, 'Constitutively active mutant D816VKit induces megakayocyte and mast cell differentiation of early haemopoietic cells from murine foetal liver', Leukemia Research, 27 547-555 (2003) [C1]
DOI10.1016/S0145-2126(02)00272-2
CitationsScopus - 21Web of Science - 23
2003To LB, Bashford J, Durrant S, Macmillan J, Schwarer AP, Prince HM, et al., 'Successful mobilisation of peripheral blood stem cell after addition of ancestim (stem cell factor) in patients who had failed a prior mobilisation with filgrastim (granulocyte colony stimulating factor) alone or with chemotherapy plus filgrastim', Bone Marrow Transplantation, 31 371-378 (2003) [C1]
DOI10.1038/sj.bmt.1703860
CitationsWeb of Science - 33
2002Ashman LK, 'CD151', Journal of Biological Regulators and Homeostatic Agents, 16 223-226 (2002) [C1]
CitationsScopus - 11Web of Science - 10
2002Frost MJ, Ferrao PT, Hughes T, Ashman LK, 'Juxtamembrane Mutant V560GKit Is more Sensitive to Imatinib (ST1571) Compared with Wild-Type c-Kit Whereas the Kinase Domain Mutant D816VKit is Resistant', Molecular Cancer Therapeutics, 1 1115-1124 (2002) [C1]
CitationsScopus - 193Web of Science - 177
2002Fletcher J, Fletcher C, Rubin B, Ashman LK, Corless C, Heinrich M, 'KIT Gene Mutations in Gastrointestinal Stromal Tumors - More Complex than Previously Recognized?', American Journal of Pathology, 161, No 2 737-738 (2002) [C3]
CitationsWeb of Science - 15
2001Geary SM, Cambaren AC, Fitter S, Ashman LK, 'Differential tissue expression of epitopes of the tetraspanin CD151 recognised by monoclonal antibodies', Tissue Antigens, 58 142-153 (2001) [C1]
CitationsWeb of Science - 28
2001Chian RJ, Young S, Danilkovitch-Miagkova A, Ronnstrand L, Leonard E, Ferrao P, et al., 'Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant', BLOOD, 98 1365-1373 (2001)
DOI10.1182/blood.V98.5.1365Author URL
CitationsWeb of Science - 89
2001Chian R, Young SM, Danilkovitch-Miagkova A, Ronnstrand L, Leonard E, Ferrao P, et al., 'PI3-kinase mediates transformation of hematopoietic cells by the V816 c-Kit mutant', Blood, 98 1365-1373 (2001) [C1]
2001Berditchevski F, Gilbert E, Griffiths MR, Fitter S, Ashman L, Jenner SJ, 'Analysis of the CD151 center dot alpha(3)beta(1) integrin and CD151 center dot tetraspanin interactions by mutagenesis.', JOURNAL OF BIOLOGICAL CHEMISTRY, 276 41165-41174 (2001)
DOI10.1074/jbc.M104041200Author URL
CitationsWeb of Science - 73
2001Berditchevksi F, Gilbert E, Griffiths MR, Fitter S, Ashman L, Jenner SJ, 'Analysis of the CD151-a3b1 integrin and CD151-tetraspanin interactions by mutagenesis 41165-41174 (2001) [C1]
2001Ferrao P, Sincock P, Cole S, Ashman L, 'Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukaemia', LEUKEMIA RESEARCH, 25 395-405 (2001)
DOI10.1016/S0145-2126(00)00156-9Author URL
CitationsWeb of Science - 37
2001Ferrao P, Sincock P, Cole S, Ashman L, 'Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukaemia (vol 25, pg 395, 2001)', LEUKEMIA RESEARCH, 25 827-827 (2001)
DOI10.1016/S0145-2126(01)00120-5Author URL
CitationsWeb of Science - 2
2001Ferrao PT, Frost MJ, Coles CJ, Domaschenz RM, Hughes TP, Ashman LK, 'Activated mutant D816VKit confers resistance to chemotherapeutic drugs, irradiation and STI 571.', CLINICAL CANCER RESEARCH, 7 3742S-3742S (2001)
Author URL
2000Linnekin D, Young S, Danilkovitch-Miagkova A, Ronnstrand L, Leonard E, Ferrao P, et al., 'PI3 kinase mediates transformation of hematopoietic cells by THF V816 c-Kit mutant.', BLOOD, 96 498A-498A (2000)
Author URL
2000Chian R, Young S, Danilkovitch-Miagkova A, Ronnstrand L, Leonard E, Ferrao P, et al., 'P13 kinase mediates transformation of hematopoietic cells by the V816 c-Kit mutant', EXPERIMENTAL HEMATOLOGY, 28 1491-1491 (2000)
DOI10.1016/S0301-472X(00)00562-2Author URL
CitationsWeb of Science - 5
2000Ashman LK, Ferrao P, Cole SR, Cambareri AC, 'Effects of mutant c-Kit in early myeloid cells (vol 34, pg 451, 1997)', LEUKEMIA & LYMPHOMA, 37 233-243 (2000)
DOI10.3109/10428190009057652Author URL
CitationsWeb of Science - 15
1999Heberlein C, Friel J, Laker C, von Laer D, Bergholz U, Bogel M, et al., 'Downregulation of c-kit (stem cell factor receptor) in transformed hematopoietic precursor cells by stroma cells', BLOOD, 93 554-563 (1999)
Author URL
CitationsWeb of Science - 5
1999Brach MA, Buhring HJ, Gruss HJ, Ashman LK, Ludwig WD, Mertelsmann RH, Herrmann F, 'Functional expression of c-kit by acute myelogenous leukemia blasts is enhanced by tumor necrosis factor-alpha through posttranscriptional mRNA stabilization by a labile protein (Retraction of vol 80, pg 1224, 1992)', BLOOD, 93 3573-3573 (1999)
Author URL
1999Brach MA, Herrmann F, Kufe DW, 'Activation of the AP-1 transcription factor by arabinofuranosylcytosine in myeloid leukemia cells (Retraction of vol 79, pg 728, 1992)', BLOOD, 93 3573-3573 (1999)
Author URL
1999Gibson MA, Leavesley DI, Ashman LK, 'Microfibril-associated glycoprotein-2 specifically interacts with a range of bovine and human cell types via alpha(v)beta(3) integrin', JOURNAL OF BIOLOGICAL CHEMISTRY, 274 13060-13065 (1999)
DOI10.1074/jbc.274.19.13060Author URL
CitationsWeb of Science - 47
1999Sincock PM, Fitter S, Parton RG, Berndt MC, Gamble JR, Ashman LK, 'PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function', JOURNAL OF CELL SCIENCE, 112 833-844 (1999)
Author URL
CitationsWeb of Science - 125
1999Fitter S, Sincock PM, Jolliffe CN, Ashman LK, 'Transmembrane 4 superfamily protein CD151 (PETA-3) associates with beta(1) and alpha(IIb)beta(3) integrins in haemopoietic cell lines and modulates cell-cell adhesion', BIOCHEMICAL JOURNAL, 338 61-70 (1999)
DOI10.1042/0264-6021:3380061Author URL
CitationsWeb of Science - 85
1999Linnekin D, Ashman L, Ferrao P, Chian R, Keller J, 'Signaling mechanisms of an oncogenic form of c-Kit in hematopoietic cells', EXPERIMENTAL HEMATOLOGY, 27 56-56 (1999)
Author URL
1999Caruana G, Cambareri AC, Ashman LK, 'Isoforms of c-KIT differ in activation of signalling pathways and transformation of NIH3T3 fibroblasts', ONCOGENE, 18 5573-5581 (1999)
DOI10.1038/sj.onc.1202939Author URL
CitationsWeb of Science - 65
1999Ashman LK, Ferrao P, Cole SR, Cambareri AC, 'Effects of mutant c-Kit in early myeloid cells', LEUKEMIA & LYMPHOMA, 34 451-461 (1999)
Author URL
CitationsWeb of Science - 22
1999Ashman LK, 'The biology of stem cell factor and its receptor C-kit', INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 31 1037-1051 (1999)
DOI10.1016/S1357-2725(99)00076-XAuthor URL
CitationsWeb of Science - 331
1998Okayama Y, Kobayashi H, Ashman LK, Dobashi K, Nakazawa T, Holgate ST, et al., 'Human lung mast cells are enriched in the capacity to produce granulocyte-macrophage colony-stimulating factor in response to IgE-dependent stimulation', EUROPEAN JOURNAL OF IMMUNOLOGY, 28 708-715 (1998)
DOI10.1002/(SICI)1521-4141(199802)28:02<708::AID-IMMU708>3.0.CO;2-AAuthor URL
CitationsWeb of Science - 27
1998Yanez-Mo M, Alfranca A, Cabanas C, Marazuela M, Tejedor R, Ursa MA, et al., 'Regulation of endothelial cell motility by complexes of tetraspan molecules CD81/TAPA-1 and CD151/PETA-3 with alpha 3 beta 1 integrin localized at endothelial lateral junctions', JOURNAL OF CELL BIOLOGY, 141 791-804 (1998)
DOI10.1083/jcb.141.3.791Author URL
CitationsWeb of Science - 192
1998Fitter S, Seldin MF, Ashman LK, 'Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms', BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1398 75-85 (1998)
DOI10.1016/S0167-4781(98)00034-7Author URL
CitationsWeb of Science - 12
1998Afonja O, Amorosi E, Ashman L, Takeshita K, 'Multilineage involvement and erythropoietin-"independent" erythroid progenitor cells in a patient with systemic mastocytosis', ANNALS OF HEMATOLOGY, 77 183-186 (1998)
DOI10.1007/s002770050439Author URL
CitationsWeb of Science - 21
1998Caruana G, Cambareri AC, Gonda TJ, Ashman LK, 'Transformation of NIH3T3 fibroblasts by the c-Kit receptor tyrosine kinase: effect of receptor density and ligand-requirement', ONCOGENE, 16 179-190 (1998)
DOI10.1038/sj.onc.1201494Author URL
CitationsWeb of Science - 23
1997Ferrao P, Gonda TJ, Ashman LK, 'Expression of constitutively activated human c-Kit in myb transformed early myeloid cells leads to factor independence, histiocytic differentiation, and tumorigenicity', BLOOD, 90 4539-4552 (1997)
Author URL
CitationsWeb of Science - 35
1997Sincock PM, Mayrhofer G, Ashman LK, 'Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: Comparison with CD9, CD63, and alpha 5 beta 1 integrin', JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 45 515-525 (1997)
Author URL
CitationsWeb of Science - 130
1997Atkins GJ, Qiao M, Coombe DR, Gowans EJ, Ashman LK, 'Hepatitis B virus binding to leucocyte plasma membranes utilizes a different region of the preS1 domain to the hepatocyte receptor binding site and does not require receptors for opsonins', IMMUNOLOGY AND CELL BIOLOGY, 75 259-266 (1997)
DOI10.1038/icb.1997.40Author URL
CitationsWeb of Science - 1
1997Sincock PM, Ashman LK, 'Expression of c-Kit and functional drug efflux are correlated in de novo acute myeloid leukaemia', LEUKEMIA, 11 1850-1857 (1997)
DOI10.1038/sj.leu.2400823Author URL
CitationsWeb of Science - 19
1997Zannettino ACW, Aylett GW, Leavesley DI, Pietsch T, Chang DG, Simmons PJ, Ashman LK, 'Specificity and functional effects of antibodies to human stem cell factor', GROWTH FACTORS, 14 67-79 (1997)
DOI10.3109/08977199709021511Author URL
CitationsWeb of Science - 2
1996Kurosawa K, Miyazawa K, Gotoh A, Katagiri T, Nishimaki J, Ashman LK, Toyama K, 'Immobilized anti-KIT monoclonal antibody induces ligand-independent dimerization and activation of steel factor receptor: Biologic similarity with membrane-bound form of steel factor rather than its soluble form', BLOOD, 87 2235-2243 (1996)
Author URL
CitationsWeb of Science - 25
1996Geary SM, Ashman LK, 'HL-60 myeloid leukaemia cells acquire immunostimulatory capability upon treatment with retinoic acid: Analysis of the responding population and mechanism of cytotoxic lymphocyte activation', IMMUNOLOGY, 88 428-440 (1996)
DOI10.1046/j.1365-2567.1996.d01-668.xAuthor URL
CitationsWeb of Science - 8
1996Zannettino ACW, Rayner JR, Ashman LK, Gonda TJ, Simmons PJ, 'A powerful new technique for isolating genes encoding cell surface antigens using retroviral expression cloning', JOURNAL OF IMMUNOLOGY, 156 611-620 (1996)
Author URL
CitationsWeb of Science - 41
1996Shimizu YJ, Ashman LK, Du ZM, Schwartz LB, 'Internalization of Kit together with stem cell factor on human fetal liver-derived mast cells - New protein and RNA synthesis is required for reappearance of Kit', JOURNAL OF IMMUNOLOGY, 156 3443-3449 (1996)
Author URL
CitationsWeb of Science - 35
1996Baghestanian M, Agis H, Bevec D, Bankl HC, Hofbauer R, Kress HG, et al., 'Stem cell factor-induced downregulation of c-kit in human lung mast cells and HMC-1 mast cells', EXPERIMENTAL HEMATOLOGY, 24 1377-1386 (1996)
Author URL
CitationsWeb of Science - 32
1996Cole SR, Aylett GW, Casey G, Harvey NL, Cambareri AC, Ashman LK, 'Increased expression of c-Kit or its ligand Steel Factor is not a common feature of adult acute myeloid leukaemia', LEUKEMIA, 10 288-296 (1996)
Author URL
CitationsWeb of Science - 32
1996Gattei V, Aldinucci D, Quinn JMW, Degan M, Cozzi M, Perin V, et al., 'Human osteoclasts and preosteoclast cells (FLG 29.1) express functional c-kit receptors and interact with osteoblast and stromal cells via membrane-bound stem cell factor', CELL GROWTH & DIFFERENTIATION, 7 753-763 (1996)
Author URL
CitationsWeb of Science - 35
1995KEES UR, ASHMAN LK, 'SYNERGISTIC ACTION OF INTERLEUKIN-2 AND STEEL FACTOR (SLF) ON A HUMAN T-LYMPHOBLASTOID CELL-LINE', LEUKEMIA, 9 1046-1050 (1995)
Author URL
CitationsWeb of Science - 10
1995SHIMIZU Y, ASHMAN L, SCHWARTZ LB, 'REGULATION OF KIT DURING STEM-CELL FACTOR (SCF)-DEPENDENT DEVELOPMENT OF FETAL LIVER-DERIVED HUMAN MAST-CELLS', FASEB JOURNAL, 9 A200-A200 (1995)
Author URL
1995FERRAO P, MACMILLAN EM, ASHMAN LK, GONDA TJ, 'ENFORCED EXPRESSION OF FULL-LENGTH C-MYB LEADS TO DENSITY-DEPENDENT TRANSFORMATION OF MURINE HEMATOPOIETIC-CELLS', ONCOGENE, 11 1631-1638 (1995)
Author URL
CitationsWeb of Science - 43
1995SHIMIZU Y, IRANI AMA, BROWN EJ, ASHMAN LK, SCHWARTZ LB, 'HUMAN MAST-CELLS DERIVED FROM FETAL LIVER-CELLS CULTURED WITH STEM-CELL FACTOR EXPRESS A FUNCTIONAL CD51/CD61 (ALPHA-V-BETA-3) INTEGRIN', BLOOD, 86 930-939 (1995)
Author URL
CitationsWeb of Science - 32
1995FITTER S, TETAZ TJ, BERNDT MC, ASHMAN LK, 'MOLECULAR-CLONING OF CDNA-ENCODING A NOVEL PLATELET-ENDOTHELIAL CELL TETRA-SPAN ANTIGEN, PETA-3', BLOOD, 86 1348-1355 (1995)
Author URL
CitationsWeb of Science - 79
1995Gattei V, Aldinucci D, Quinn JMW, Degan M, Cozzi M, Perin V, et al., 'Human primary osteoclasts and preosteoclast cells (FLG 29.1) express functional c-kit receptors and interact with osteoblast and stromal cells via membrane-bound stem cell factor (mb-SCF)', BLOOD, 86 79-79 (1995)
Author URL
1995Ashman LK, Sincock PM, Cole SR, 'Functional drug efflux P-glycoprotein and c-Kit expression in acute myeloid leukemia.', BLOOD, 86 2048-2048 (1995)
Author URL
1995Zannettino ACW, Buhring HJ, Niutta S, Ashman LK, Kanz L, Simmons PJ, 'Identification and functional cloning of MGC-24, a mucin-like molecule expressed by haemopoietic progenitors and bone marrow stromal cells: A negative regulator of haemopoiesis', BLOOD, 86 2350-2350 (1995)
Author URL
CitationsWeb of Science - 1
1995ROBERTS JJ, RODGERS SE, DRURY J, ASHMAN LK, LLOYD JV, 'PLATELET ACTIVATION-INDUCED BY A MURINE MONOCLONAL-ANTIBODY DIRECTED AGAINST A NOVEL TETRA-SPAN ANTIGEN', BRITISH JOURNAL OF HAEMATOLOGY, 89 853-860 (1995) [C1]
Author URL
CitationsScopus - 35Web of Science - 36
1995IRANI AA, NILSSON G, ASHMAN LK, SCHWARTZ LB, 'DEXAMETHASONE INHIBITS THE DEVELOPMENT OF MAST-CELLS FROM DISPERSED HUMAN FETAL LIVER-CELLS CULTURED IN THE PRESENCE OF RECOMBINANT HUMAN STEM-CELL FACTOR', IMMUNOLOGY, 84 72-78 (1995)
Author URL
CitationsWeb of Science - 23
1995ASHMAN LK, AYLETT GW, CAMBARERI AC, LEVESQUE JP, SIMMONS PJ, 'STEEL FACTOR AND ITS RECEPTOR C-KIT MEDIATE CELL-CELL INTERACTIONS', JOURNAL OF INVESTIGATIVE DERMATOLOGY, 105 2-2 (1995)
Author URL
1994NILSSON G, MIETTINEN U, ISHIZAKA T, ASHMAN LK, IRANI AM, SCHWARTZ LB, 'INTERLEUKIN-4 INHIBITS THE EXPRESSION OF KIT AND TRYPTASE DURING STEM-CELL FACTOR-DEPENDENT DEVELOPMENT OF HUMAN MAST-CELLS FROM FETAL LIVER-CELLS', BLOOD, 84 1519-1527 (1994)
Author URL
CitationsWeb of Science - 57
1994TO LB, HAYLOCK DN, DOWSE T, SIMMONS PJ, TRIMBOLI S, ASHMAN LK, JUTTNER CA, 'A COMPARATIVE-STUDY OF THE PHENOTYPE AND PROLIFERATIVE CAPACITY OF PERIPHERAL-BLOOD (PB) CD34(+) CELLS MOBILIZED BY 4 DIFFERENT PROTOCOLS AND THOSE OF STEADY-PHASE PB AND BONE-MARROW CD34(+) CELLS', BLOOD, 84 2930-2939 (1994)
Author URL
CitationsWeb of Science - 202
1994KUROSAWA K, MIYAZAWA K, GOTOH A, NISHIMAKI J, ASHMAN LK, TOYAMA K, 'IMMOBILIZED YB5.B8 MONOCLONAL-ANTIBODY INDUCES LIGAND-INDEPENDENT DIMERIZATION AND ACTIVATION OF C-KIT ENCODED PROTEIN - BIOLOGICAL SIMILARITY WITH MEMBRANE-BOUND FORM OF STEEL FACTOR RATHER THAN ITS SOLUBLE FORM', BLOOD, 84 A123-A123 (1994)
Author URL
1994ASHMAN LK, FITTER S, TETAZ T, BERNDT MC, 'MOLECULAR-CLONING OF CDNA-ENCODING A NOVEL PLATELET ENDOTHELIAL-CELL TETRASPAN ANTIGEN', BLOOD, 84 A243-A243 (1994)
Author URL
1994ASHMAN LK, BUHRING HJ, AYLETT GW, BROUDY VC, MULLER C, 'EPITOPE MAPPING AND FUNCTIONAL-STUDIES WITH 3 MONOCLONAL-ANTIBODIES TO THE C-KIT RECEPTOR TYROSINE KINASE, YB5.B8, 17F11, AND SR-1', JOURNAL OF CELLULAR PHYSIOLOGY, 158 545-554 (1994)
DOI10.1002/jcp.1041580321Author URL
CitationsWeb of Science - 26
1994OKAYAMA Y, HUNT TC, KASSEL O, ASHMAN LK, CHURCH MK, 'ASSESSMENT OF THE ANTI-C-KIT MONOCLONAL-ANTIBODY YB5.B8 IN AFFINITY MAGNETIC ENRICHMENT OF HUMAN LUNG MAST-CELLS', JOURNAL OF IMMUNOLOGICAL METHODS, 169 153-161 (1994)
DOI10.1016/0022-1759(94)90259-3Author URL
CitationsWeb of Science - 57
1994GRABBE J, WELKER P, MOLLER A, DIPPEL E, ASHMAN LK, CZARNETZKI BM, 'COMPARATIVE CYTOKINE RELEASE FROM HUMAN MONOCYTES, MONOCYTE-DERIVED IMMATURE MAST-CELLS, AND A HUMAN MAST-CELL LINE (HMC-1)', JOURNAL OF INVESTIGATIVE DERMATOLOGY, 103 504-508 (1994)
DOI10.1111/1523-1747.ep12395649Author URL
CitationsWeb of Science - 55
1994SIMMONS PJ, AYLETT GW, NIUTTA S, TO LB, JUTTNER CA, ASHMAN LK, 'C-KIT IS EXPRESSED BY PRIMITIVE HUMAN HEMATOPOIETIC-CELLS THAT GIVE RISE TO COLONY-FORMING CELLS IN STROMA-DEPENDENT CYTOKINE-SUPPLEMENTED CULTURE', EXPERIMENTAL HEMATOLOGY, 22 157-165 (1994)
Author URL
CitationsWeb of Science - 72
1994OKAYAMA Y, HUNT TC, KASSEL O, ASHMAN L, CHURCH MK, 'ASSESSMENT OF THE ANTI-C-KIT MONOCLONAL-ANTIBODY - YB5,B8 IN MAGNETIC AFFINITY ENRICHMENT OF HUMAN MAST-CELLS PREPARATIONS', CLINICAL AND EXPERIMENTAL ALLERGY, 24 179-179 (1994)
Author URL
1994SIMMONS PJ, LEAVESLEY DI, LEVESQUE JP, SWART BW, HAYLOCK DN, TO LB, et al., 'THE MOBILIZATION OF PRIMITIVE HEMATOPOIETIC PROGENITORS INTO THE PERIPHERAL-BLOOD', STEM CELLS, 12 187-202 (1994)
Author URL
CitationsWeb of Science - 42
1993TO LB, HAYLOCK DN, DOWSE T, SIMMONS PJ, ASHMAN LK, JUTTNER CA, 'PHENOTYPE AND PROLIFERATIVE CAPACITY OF PERIPHERAL-BLOOD CD34+ CELLS MOBILIZED BY 4 DIFFERENT PROTOCOLS', BLOOD, 82 A493-A493 (1993)
Author URL
CitationsWeb of Science - 1
1993LLOYD JV, ROBERTS JJ, RODGERS SE, ASHMAN LK, 'PLATELET ACTIVATION BY THE MURINE MONOCLONAL ANTIBODY-14A2.H1', BLOOD, 82 A609-A609 (1993)
Author URL
1993NILSSON G, FORSBERG K, BODGER MP, ASHMAN LK, ZSEBO KM, ISHIZAKA T, et al., 'PHENOTYPIC CHARACTERIZATION OF STEM-CELL FACTOR-DEPENDENT HUMAN FETAL LIVER-DERIVED MAST-CELLS', IMMUNOLOGY, 79 325-330 (1993)
Author URL
CitationsWeb of Science - 50
1993TOHDA S, YANG GS, ASHMAN LK, MCCULLOCH EA, MINDEN MD, 'RELATIONSHIP BETWEEN C-KIT EXPRESSION AND PROLIFERATION IN ACUTE MYELOBLASTIC-LEUKEMIA CELL-LINES', JOURNAL OF CELLULAR PHYSIOLOGY, 154 410-418 (1993)
DOI10.1002/jcp.1041540225Author URL
CitationsWeb of Science - 29
1993FURITSU T, TSUJIMURA T, TONO T, IKEDA H, KITAYAMA H, KOSHIMIZU U, et al., 'IDENTIFICATION OF MUTATIONS IN THE CODING SEQUENCE OF THE PROTOONCOGENE C-KIT IN A HUMAN MAST-CELL LEUKEMIA-CELL LINE CAUSING LIGAND-INDEPENDENT ACTIVATION OF C-KIT PRODUCT', JOURNAL OF CLINICAL INVESTIGATION, 92 1736-1744 (1993)
DOI10.1172/JCI116761Author URL
CitationsWeb of Science - 604
1993MATOS ME, SCHNIER GS, BEECHER MS, ASHMAN LK, WILLIAMS DE, CALIGIURI MA, 'EXPRESSION OF A FUNCTIONAL C-KIT RECEPTOR ON A SUBSET OF NATURAL-KILLER-CELLS', JOURNAL OF EXPERIMENTAL MEDICINE, 178 1079-1084 (1993)
DOI10.1084/jem.178.3.1079Author URL
CitationsWeb of Science - 113
1993ASANO Y, BRACH MA, AHLERS A, DEVOS S, BUTTERFIELD JH, ASHMAN LK, et al., 'PHORBOL ESTER 12-O-TETRADECANOYLPHORBOL-13-ACETATE DOWN-REGULATES EXPRESSION OF THE C-KIT PROTOONCOGENE PRODUCT', JOURNAL OF IMMUNOLOGY, 151 2345-2354 (1993)
Author URL
CitationsWeb of Science - 14
1993MAZE R, HORIE M, HENDRIE P, VADHANRAJ S, TRICOT G, GORDON M, et al., 'DIFFERENTIAL RESPONSES OF MYELOID PROGENITOR CELLS FROM PATIENTS WITH MYELOID-LEUKEMIA AND MYELODYSPLASIA TO THE COSTIMULATING EFFECTS OF STEEL FACTOR IN-VITRO', EXPERIMENTAL HEMATOLOGY, 21 545-551 (1993)
Author URL
CitationsWeb of Science - 15
1993CARUANA G, ASHMAN LK, FUJITA J, GONDA TJ, 'RESPONSES OF THE MURINE MYELOID CELL-LINE FDC-P1 TO SOLUBLE AND MEMBRANE-BOUND FORMS OF STEEL FACTOR (SLF)', EXPERIMENTAL HEMATOLOGY, 21 761-768 (1993)
Author URL
CitationsWeb of Science - 37
1993ATKINS GJ, GOWANS EJ, ASHMAN LK, 'HEPATITIS-B VIRUS RECEPTORS ON HEMATOPOIETIC-CELLS', JOURNAL OF LEUKOCYTE BIOLOGY, 46-46 (1993)
Author URL
1993GEARY SM, ASHMAN LK, 'IMMUNOSTIMULATORY NATURE OF A HUMAN LEUKEMIC-CELL LINE, HL-60, AFTER TREATMENT WITH RETINOIC ACID', JOURNAL OF LEUKOCYTE BIOLOGY, 89-89 (1993)
Author URL
1993ZANNETTINO ACW, RAYNER J, ASHMAN LK, GONDA TJ, SIMMONS PJ, 'USE OF A RETROVIRAL CDNA EXPRESSION LIBRARY TO CLONE GENES ENCODING NOVEL HUMAN STROMAL CELL ANTIGENS', JOURNAL OF LEUKOCYTE BIOLOGY, 103-103 (1993)
Author URL
1993FITTER S, BERNDT MC, ZANNETTINO ACW, ASHMAN LK, 'MOLECULAR-CLONING OF CDNA-ENCODING A NOVEL HUMAN PLATELET MEGAKARYOCYTE SURFACE-ANTIGEN', JOURNAL OF LEUKOCYTE BIOLOGY, 103-103 (1993)
Author URL
1993TOHDA S, ASHMAN LK, MINDEN MD, 'THE ROLE OF STROMA CELLS ON THE PROLIFERATION AND C-KIT EXPRESSION OF ACUTE MYELOBLASTIC-LEUKEMIA CELLS', INTERNATIONAL JOURNAL OF ONCOLOGY, 3 1141-1147 (1993)
Author URL
1992CICUTTINI FM, MARTIN M, SALVARIS E, ASHMAN L, BEGLEY CG, NOVOTNY J, et al., 'SUPPORT OF HUMAN CORD BLOOD PROGENITOR CELLS ON HUMAN STROMAL CELL-LINES TRANSFORMED BY SV(40) LARGE T-ANTIGEN UNDER THE INFLUENCE OF AN INDUCIBLE (METALLOTHIONEIN) PROMOTER', BLOOD, 80 102-112 (1992)
Author URL
CitationsWeb of Science - 37
1992BRACH MA, BUHRING HJ, GRUSS HJ, ASHMAN LK, LUDWIG WD, MERTELSMANN RH, HERRMANN F, 'FUNCTIONAL EXPRESSION OF C-KIT BY ACUTE MYELOGENOUS LEUKEMIA BLASTS IS ENHANCED BY TUMOR-NECROSIS-FACTOR-ALPHA THROUGH POSTTRANSCRIPTIONAL MESSENGER-RNA STABILIZATION BY A LABILE PROTEIN (RETRACTED ARTICLE. SEE VOL 93, PG. 3573, 1999)', BLOOD, 80 1224-1230 (1992)
Author URL
CitationsWeb of Science - 28
1992IRANI AMA, NILSSON G, MIETTINEN U, CRAIG SS, ASHMAN LK, ISHIZAKA T, et al., 'RECOMBINANT HUMAN STEM-CELL FACTOR STIMULATES DIFFERENTIATION OF MAST-CELLS FROM DISPERSED HUMAN FETAL LIVER-CELLS', BLOOD, 80 3009-3021 (1992)
Author URL
CitationsWeb of Science - 209
1992JACOBSON MR, BENTLEY AM, CUMBERWORTH V, SCHWARTZ LB, IRANI AM, ASHMAN LK, et al., 'IMMUNOHISTOLOGY OF THE NASAL-MUCOSA IN SEASONAL ALLERGIC RHINITIS - INCREASES IN ACTIVATED EOSINOPHILS AND EPITHELIAL MAST-CELLS', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 89 216-216 (1992)
Author URL
CitationsWeb of Science - 1
1992HUNT TC, HEUSSER C, MUELLER R, BULLOCK G, OKAYAMA Y, ASHMAN LK, CHURCH MK, 'HUMAN LUNG MAST-CELLS PRODUCE INTERLEUKIN-4', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 89 245-245 (1992)
Author URL
CitationsWeb of Science - 4
1992MAZE R, HORIE M, HENDRIE PC, VADHANRAJ S, TRICOT G, ASHMAN LK, BROXMEYER HE, 'HETEROGENEOUS RESPONSIVENESS INVITRO OF MYELOID PROGENITOR CELLS FROM PATIENTS WITH MYELOID-LEUKEMIA TO THE CO-STIMULATING EFFECTS OF STEEL FACTOR', EXPERIMENTAL HEMATOLOGY, 20 761-761 (1992)
Author URL
1992SIMMONS PJ, NIUTTA S, ASHMAN LK, BERNDT MC, JUTTNER CA, 'PRIMITIVE HUMAN BONE-MARROW PROGENITORS EXPRESS L-SELECTIN AND PECAM-1(CD31)', EXPERIMENTAL HEMATOLOGY, 20 829-829 (1992)
Author URL
CitationsWeb of Science - 2
1991ASHMAN LK, AYLETT GW, CAMBARERI AC, COLE S, 'DIFFERENT EPITOPES OF THE CD31 ANTIGEN IDENTIFIED BY MONOCLONAL-ANTIBODIES - CELL TYPE-SPECIFIC PATTERNS OF EXPRESSION', TISSUE ANTIGENS, 38 199-207 (1991)
DOI10.1111/j.1399-0039.1991.tb01898.xAuthor URL
CitationsWeb of Science - 26
1991ASHMAN LK, AYLETT GW, 'EXPRESSION OF CD31-EPITOPES ON HUMAN-LYMPHOCYTES - CD31-MONOCLONAL ANTIBODIES DIFFERENTIATE BETWEEN NAIVE (CD45RA+) AND MEMORY (CD45RA-) CD4-POSITIVE T-CELLS', TISSUE ANTIGENS, 38 208-212 (1991)
DOI10.1111/j.1399-0039.1991.tb01899.xAuthor URL
CitationsWeb of Science - 34
1991LERNER NB, NOCKA KH, COLE S, QIU FH, STRIFE A, ASHMAN LK, BESMER P, 'MONOCLONAL ANTIBODY-YB5.B8 IDENTIFIES THE HUMAN C-KIT PROTEIN PRODUCT', BLOOD, 77 1876-1883 (1991)
Author URL
CitationsWeb of Science - 166
1991ASHMAN LK, CAMBARERI AC, TO LB, LEVINSKY RJ, JUTTNER CA, 'EXPRESSION OF THE YB5.B8 ANTIGEN (C-KIT PROTOONCOGENE PRODUCT) IN NORMAL HUMAN BONE-MARROW', BLOOD, 78 30-37 (1991)
Author URL
CitationsWeb of Science - 180
1991ASHMAN LK, AYLETT GW, MEHRABANI PA, BENDALL LJ, NIUTTA S, CAMBARERI AC, et al., 'THE MURINE MONOCLONAL-ANTIBODY, 14A2.H1, IDENTIFIES A NOVEL PLATELET SURFACE-ANTIGEN', BRITISH JOURNAL OF HAEMATOLOGY, 79 263-270 (1991)
DOI10.1111/j.1365-2141.1991.tb04531.xAuthor URL
CitationsWeb of Science - 23
1991SILLABER C, STROBL H, BEVEC D, ASHMAN LK, BUTTERFIELD JH, LECHNER K, et al., 'IL-4 REGULATES C-KIT PROTOONCOGENE PRODUCT EXPRESSION IN HUMAN MAST AND MYELOID PROGENITOR CELLS', JOURNAL OF IMMUNOLOGY, 147 4224-4228 (1991)
Author URL
CitationsWeb of Science - 121
1991MIYAZAWA K, HENDRIE PC, MANTEL C, WOOD K, ASHMAN LK, BROXMEYER HE, 'COMPARATIVE-ANALYSIS OF SIGNALING PATHWAYS BETWEEN MAST-CELL GROWTH-FACTOR (C-KIT LIGAND) AND GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN A HUMAN FACTOR-DEPENDENT MYELOID CELL-LINE INVOLVES PHOSPHORYLATION OF RAF-1, GTPASE-ACTIVATING PROTEIN AND MITOGEN-ACTIVATED PROTEIN-KINASE', EXPERIMENTAL HEMATOLOGY, 19 1110-1123 (1991)
Author URL
CitationsWeb of Science - 134
1990ASHMAN LK, CAMBARERI AC, EGLINTON JM, 'A MONOCLONAL-ANTIBODY THAT INHIBITS THE ACTION OF GM-CSF ON NORMAL BUT NOT LEUKEMIC PROGENITORS', LEUKEMIA RESEARCH, 14 637-644 (1990)
DOI10.1016/0145-2126(90)90019-6Author URL
CitationsWeb of Science - 9
1989VALENT P, ASHMAN LK, HINTERBERGER W, ECKERSBERGER F, MAJDIC O, LECHNER K, BETTELHEIM P, 'MAST-CELL TYPING - DEMONSTRATION OF A DISTINCT HEMATOPOIETIC-CELL TYPE AND EVIDENCE FOR IMMUNOPHENOTYPIC RELATIONSHIP TO MONONUCLEAR PHAGOCYTES', BLOOD, 73 1778-1785 (1989)
Author URL
CitationsWeb of Science - 201
1989COLE S, KRIEK GW, HOPE RM, ASHMAN LK, 'TRANSFECTION OF GENES FOR HUMAN CELL-SURFACE ANTIGENS IDENTIFIED BY MONOCLONAL-ANTIBODIES', IMMUNOLOGY AND CELL BIOLOGY, 67 377-384 (1989)
DOI10.1038/icb.1989.54Author URL
CitationsWeb of Science - 5
1988LYONS AB, COOPER SJ, COLE S, ASHMAN LK, 'HUMAN MYELOID DIFFERENTIATION ANTIGENS IDENTIFIED BY MONOCLONAL-ANTIBODIES TO THE MYELOMONOCYTIC LEUKEMIA-CELL LINE RC-2A', PATHOLOGY, 20 137-146 (1988)
Author URL
CitationsWeb of Science - 16
1988LYONS AB, ASHMAN LK, 'THE EFFECT OF RECOMBINANT CYTOKINES ON THE PROLIFERATIVE POTENTIAL AND PHENOTYPE OF CELLS OF THE HUMAN MYELOMONOCYTIC LEUKEMIA LINE, RC-2A', LEUKEMIA RESEARCH, 12 659-666 (1988)
DOI10.1016/0145-2126(88)90100-2Author URL
CitationsWeb of Science - 3
1988ASHMAN LK, ROBERTS MM, GADD SJ, COOPER SJ, JUTTNER CA, 'EXPRESSION OF A 150-KD CELL-SURFACE ANTIGEN IDENTIFIED BY MONOCLONAL-ANTIBODY YB5.B8 IS ASSOCIATED WITH POOR PROGNOSIS IN ACUTE NON-LYMPHOBLASTIC LEUKEMIA', LEUKEMIA RESEARCH, 12 923-928 (1988)
DOI10.1016/0145-2126(88)90020-3Author URL
CitationsWeb of Science - 72
1988CAMBARERI AC, ASHMAN LK, COLE S, LYONS AB, 'A MONOCLONAL-ANTIBODY TO A HUMAN MAST-CELL MYELOID LEUKEMIA-SPECIFIC ANTIGEN BINDS TO NORMAL HEMATOPOIETIC PROGENITOR CELLS AND INHIBITS COLONY FORMATION INVITRO', LEUKEMIA RESEARCH, 12 929-& (1988)
DOI10.1016/0145-2126(88)90021-5Author URL
CitationsWeb of Science - 27
1987VALENT P, STAIN C, ASHMAN LK, BRANTSCHEN S, STADLER BM, HINTERBERGER W, et al., 'THE PHENOTYPE OF HUMAN CONNECTIVE-TISSUE TYPE (CTMC) AND MUCOSAL MAST-CELLS (MMC)', BLUT, 55 360-360 (1987)
Author URL
1987WHITE DL, ASHMAN LK, DART GW, ZOLA H, TOOGOOD IRG, KIMBER RJ, 'THE EXPRESSION OF MATURE MYELOID CELL-DIFFERENTIATION MARKERS IN ACUTE-LEUKEMIA', PATHOLOGY, 19 137-142 (1987)
Author URL
CitationsWeb of Science - 12
1987ASHMAN L, ROBERTS M, GADD S, COOPER S, JUTTNER C, 'A SUBGROUP OF ANLL WITH POOR RESPONSE TO STANDARD CHEMOTHERAPY IDENTIFIED BY A MONOCLONAL-ANTIBODY', MEDICAL AND PEDIATRIC ONCOLOGY, 15 152-152 (1987)
Author URL
1987ASHMAN LK, WHITE D, ZOLA H, DART GW, 'EXPRESSION OF THE NON-T ALL-ASSOCIATED P24 ANTIGEN ON LEUKEMIC BLASTS FROM PATIENTS WITH ANLL', LEUKEMIA RESEARCH, 11 97-& (1987)
DOI10.1016/0145-2126(87)90109-3Author URL
CitationsWeb of Science - 8
1987LYONS AB, ASHMAN LK, 'STUDIES ON THE DIFFERENTIATION OF THE HUMAN MYELOMONOCYTIC CELL-LINE RC-2A IN RESPONSE TO LYMPHOCYTE-DERIVED FACTORS', LEUKEMIA RESEARCH, 11 797-& (1987)
DOI10.1016/0145-2126(87)90064-6Author URL
CitationsWeb of Science - 3
1987COLE S, ASHMAN LK, EY PL, 'BIOTINYLATION - AN ALTERNATIVE TO RADIOIODINATION FOR THE IDENTIFICATION OF CELL-SURFACE ANTIGENS IN IMMUNOPRECIPITATES', MOLECULAR IMMUNOLOGY, 24 699-705 (1987)
DOI10.1016/0161-5890(87)90051-4Author URL
CitationsWeb of Science - 166
1987ASHMAN LK, KRIEK GW, COOPER SJ, OKEEFE DE, 'REQUIREMENTS FOR THE STIMULATION OF ALLOGENEIC LYMPHOCYTES-T BY ACUTE NONLYMPHOBLASTIC LEUKEMIA-CELLS', CANCER IMMUNOLOGY IMMUNOTHERAPY, 25 250-256 (1987)
Author URL
CitationsWeb of Science - 3
1987ASHMAN LK, DREW PA, TOOGOOD IRG, JUTTNER CA, 'IMMUNOLOGICAL COMPETENCE OF PATIENTS IN REMISSION FROM ACUTE-LEUKEMIA - APPARENTLY NORMAL T-CELL FUNCTION BUT DEFECTIVE POKEWEED MITOGEN-DRIVEN IMMUNOGLOBULIN-SYNTHESIS', IMMUNOLOGY AND CELL BIOLOGY, 65 201-210 (1987)
DOI10.1038/icb.1987.22Author URL
1987MAYRHOFER G, GADD SJ, SPARGO LDJ, ASHMAN LK, 'SPECIFICITY OF A MOUSE MONOCLONAL-ANTIBODY RAISED AGAINST ACUTE MYELOID-LEUKEMIA CELLS FOR MAST-CELLS IN HUMAN MUCOSAL AND CONNECTIVE TISSUES', IMMUNOLOGY AND CELL BIOLOGY, 65 241-250 (1987)
DOI10.1038/icb.1987.27Author URL
CitationsWeb of Science - 92
1987ASHMAN LK, 'THE IMMUNOGENICITY OF TUMOR-CELLS', IMMUNOLOGY AND CELL BIOLOGY, 65 271-277 (1987)
DOI10.1038/icb.1987.31Author URL
CitationsWeb of Science - 6
1986WHITE DL, ASHMAN LK, DART GW, ZOLA H, KIMBER RJ, 'THE SELECTION OF A PANEL OF LOCALLY PRODUCED MONOCLONAL-ANTIBODIES FOR THE CLASSIFICATION OF ACUTE LEUKEMIAS', AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 16 124-124 (1986)
Author URL
1986EY PL, ASHMAN LK, 'THE USE OF ALKALINE PHOSPHATASE-CONJUGATED ANTIIMMUNOGLOBULIN WITH IMMUNOBLOTS FOR DETERMINING THE SPECIFICITY OF MONOCLONAL-ANTIBODIES TO PROTEIN MIXTURES', METHODS IN ENZYMOLOGY, 121 497-509 (1986)
Author URL
CitationsWeb of Science - 107
1986ASHMAN LK, OKEEFE DE, JUTTNER CA, TOOGOOD IRG, RICE MS, 'AUTOLOGOUS RESPONSES TO HUMAN-LEUKEMIC CELLS IN MIXED LEUKOCYTE-CULTURE', CANCER IMMUNOLOGY IMMUNOTHERAPY, 22 95-99 (1986)
Author URL
CitationsWeb of Science - 7
1985GADD SJ, BROGAN MP, ASHMAN LK, 'SPECIFICITY OF THE PASSIVE ANTIBODY-INDUCED SUPPRESSION OF THE HUMORAL IMMUNE-RESPONSE OF MICE TO SURFACE-ANTIGENS ON HUMAN-CELLS', IMMUNOLOGY, 54 223-231 (1985)
Author URL
CitationsWeb of Science - 5
1985GESCHE AH, ASHMAN LK, 'VARIATIONS IN ANTIGEN EXPRESSION DURING THE CELL-CYCLE OF A HUMAN B-LYMPHOBLASTOID CELL-LINE', LEUKEMIA RESEARCH, 9 147-& (1985)
DOI10.1016/0145-2126(85)90028-1Author URL
CitationsWeb of Science - 6
1985ASHMAN LK, GESCHE AH, 'SURFACE-ANTIGEN EXPRESSION BY A HUMAN B-LYMPHOBLASTOID CELL-LINE TREATED WITH DIFFERENTIATION INDUCERS, DIMETHYSULFOXIDE AND TETRADECANOYLPHORBOL ACETATE', LEUKEMIA RESEARCH, 9 157-& (1985)
DOI10.1016/0145-2126(85)90029-3Author URL
CitationsWeb of Science - 7
1985GADD SJ, ASHMAN LK, 'A MURINE MONOCLONAL-ANTIBODY SPECIFIC FOR A CELL-SURFACE ANTIGEN EXPRESSED BY A SUBGROUP OF HUMAN MYELOID LEUKEMIAS', LEUKEMIA RESEARCH, 9 1329-1336 (1985)
DOI10.1016/0145-2126(85)90119-5Author URL
CitationsWeb of Science - 70
1985LYONS AB, ASHMAN LK, 'THE ROSE-BENGAL ASSAY FOR MONOCLONAL-ANTIBODIES TO CELL-SURFACE ANTIGENS - COMPARISONS WITH COMMON HYBRIDOMA SCREENING METHODS', JOURNAL OF IMMUNOASSAY, 6 325-345 (1985)
DOI10.1080/01971528508063037Author URL
CitationsWeb of Science - 5
1984ASHMAN LK, 'PROLIFERATIVE RESPONSE OF NORMAL AND ACTIVATED HUMAN-LYMPHOCYTES TO TETRADECANOYL PHORBOL ACETATE', CELLULAR IMMUNOLOGY, 87 613-625 (1984)
DOI10.1016/0008-8749(84)90029-7Author URL
CitationsWeb of Science - 18
1983GADD SJ, ASHMAN LK, 'BINDING OF MOUSE MONOCLONAL-ANTIBODIES TO HUMAN-LEUKEMIC CELLS VIA THE FC RECEPTOR - A POSSIBLE SOURCE OF FALSE POSITIVE REACTIONS IN SPECIFICITY SCREENING', CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 54 811-818 (1983)
Author URL
CitationsWeb of Science - 39
1983ASHMAN LK, 'IMMUNE-RESPONSES TO HUMAN-LEUKEMIC CELLS-INVITRO', MEDICAL AND PEDIATRIC ONCOLOGY, 11 197-197 (1983)
Author URL
1983ASHMAN LK, 'STIMULATORY ABILITY OF HUMAN-LEUKEMIC CELLS IN THE ALLOGENEIC MIXED LEUKOCYTE REACTION', AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 61 477-488 (1983)
DOI10.1038/icb.1983.45Author URL
CitationsWeb of Science - 4
1982OKEEFE D, ASHMAN L, 'PEANUT AGGLUTININ - A MARKER FOR NORMAL AND LEUKEMIC-CELLS OF THE MONOCYTE LINEAGE', CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 48 329-338 (1982)
Author URL
CitationsWeb of Science - 29
1982OKEEFE D, ASHMAN L, 'VARIATION IN ACCESSORY CELL REQUIREMENTS IN HUMAN MIXED LYMPHOCYTE-RESPONSE TO LEUKEMIC-CELL LINES', IMMUNOLOGY, 47 633-641 (1982)
Author URL
CitationsWeb of Science - 17
1982OCONNOR CG, ASHMAN LK, 'APPLICATION OF THE NITROCELLULOSE TRANSFER TECHNIQUE AND ALKALINE-PHOSPHATASE CONJUGATED ANTI-IMMUNOGLOBULIN FOR DETERMINATION OF THE SPECIFICITY OF MONOCLONAL-ANTIBODIES TO PROTEIN MIXTURES', JOURNAL OF IMMUNOLOGICAL METHODS, 54 267-271 (1982)
DOI10.1016/0022-1759(82)90068-0Author URL
CitationsWeb of Science - 109
1982ASHMAN LK, MURRAY AW, COOK MG, KOTLARSKI I, '2-STAGE SKIN CARCINOGENESIS IN SENSITIVE AND RESISTANT MOUSE STRAINS', CARCINOGENESIS, 3 99-102 (1982)
DOI10.1093/carcin/3.1.99Author URL
CitationsWeb of Science - 25
1980VINGELIS V, ASHMAN LK, KOTLARSKI I, 'FACTORS AFFECTING THE ABILITY OF VARIOUS STRAINS OF ENTEROBACTERIACEAE TO INDUCE TUMOR RESISTANCE IN MICE', AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 58 123-131 (1980)
DOI10.1038/icb.1980.12Author URL
CitationsWeb of Science - 4
1980ASHMAN LK, GOH DHB, KOTLARSKI I, 'INVOLVEMENT OF DONOR LYMPHORETICULAR CELLS IN THE REJECTION OF B-16 MELANOMA BY ALLOGENEIC MICE', AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 58 159-166 (1980)
DOI10.1038/icb.1980.16Author URL
CitationsWeb of Science - 11
1980DEYOUNG NJ, ASHMAN LK, LUDBROOK J, MARSHALL VR, 'COMPARISON OF 3 BLOOD-TESTS FOR CANCER', SURGERY GYNECOLOGY & OBSTETRICS, 150 12-16 (1980)
Author URL
CitationsWeb of Science - 6
1979DEYOUNG NJ, ASHMAN LK, LUDBROOK J, MARSHALL VR, 'CANCER DISCRIMINATORY ABILITY OF THE CARCINOEMBRYONIC ANTIGEN-ASSAY, PHOSPHOHEXOSE ISOMERASE ACTIVITY AND ERYTHROCYTE SEDIMENTATION-RATE', AUSTRALIAN AND NEW ZEALAND JOURNAL OF SURGERY, 49 145-146 (1979)
Author URL
1979ASHMAN LK, KOTLARSKI I, 'INHIBITION OF THE GROWTH OF LEWIS LUNG-CARCINOMA IN SYNGENEIC MICE BY SALMONELLA ANTIGENS', AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 57 637-639 (1979)
DOI10.1038/icb.1979.67Author URL
CitationsWeb of Science - 1
1979ASHMAN LK, COOK MG, KOTLARSKI I, 'PROTECTIVE EFFECT OF ORAL SALMONELLA-ENTERITIDIS 11RX INFECTION AGAINST COLON-TUMOR INDUCTION BY 1,2-DIMETHYLHYDRAZINE IN MICE', CANCER RESEARCH, 39 2768-2771 (1979)
Author URL
CitationsWeb of Science - 5
1978DEYOUNG NJ, ASHMAN LK, 'PHYSICOCHEMICAL AND IMMUNOCHEMICAL PROPERTIES OF CARCINOEMBRYONIC ANTIGEN (CEA) FROM DIFFERENT TUMOR SOURCES', AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 56 321-331 (1978)
DOI10.1038/icb.1978.34Author URL
CitationsWeb of Science - 14
1978ASHMAN LK, KOTLARSKI I, 'EFFECT OF SALMONELLA-ENTERITIDIS 11RX INFECTION ON 2-STAGE SKIN CARCINOGENESIS IN MICE', AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 56 695-701 (1978)
DOI10.1038/icb.1978.76Author URL
CitationsWeb of Science - 11
1977ASHMAN LK, LUDBROOK J, MARSHALL VR, 'COMPARISON OF WHOLE PLASMA AND PERCHLORIC ACID-EXTRACTED PLASMA ASSAYS FOR CARCINOEMBRYONIC ANTIGEN', CLINICA CHIMICA ACTA, 74 77-84 (1977)
DOI10.1016/0009-8981(77)90390-4Author URL
CitationsWeb of Science - 9
1977ASHMAN LK, DEYOUNG NJ, 'IMMUNOADSORBENT PURIFICATION OF CARCINOEMBRYONIC ANTIGEN', IMMUNOCHEMISTRY, 14 329-336 (1977)
DOI10.1016/0019-2791(77)90232-4Author URL
CitationsWeb of Science - 7
1975ASHMAN LK, DEYOUNG NJ, GEARY D, LUDBROOK J, 'CARCINOEMBRYONIC ANTIGEN LEVELS IN PLASMA OF CANCER-PATIENTS AND OF CANCER-FREE HOSPITAL INPATIENTS', AUSTRALIAN AND NEW ZEALAND JOURNAL OF SURGERY, 45 109-109 (1975)
Author URL
1975ASHMAN LK, KEECH DB, 'KINETIC APPROACH TO DEFINING ROLE OF CHEMICALLY MODIFIABLE RESIDUES AT ACTIVE-SITES OF ENZYMES', AUSTRALIAN JOURNAL OF BIOLOGICAL SCIENCES, 28 379-387 (1975)
Author URL
CitationsWeb of Science - 2
1975ASHMAN LK, KEECH DB, 'SHEEP KIDNEY PYRUVATE-CARBOXYLASE - STUDIES ON COUPLING OF ADENOSINE-TRIPHOSPHATE HYDROLYSIS AND CO2 FIXATION', JOURNAL OF BIOLOGICAL CHEMISTRY, 250 14-21 (1975)
Author URL
CitationsWeb of Science - 52
1975ASHMAN LK, DEYOUNG NJ, 'IMMUNOADSORBENT PURIFICATION OF A GLYCOPROTEIN FROM HUMAN TUMOR TISSUE', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 8 40-40 (1975)
Author URL
1975ASHMAN LK, 'PURIFICATION OF CARCINOEMBRYONIC ANTIGEN BY AFFINITY CHROMATOGRAPHY USING IMMOBILIZED ANTIBODIES', CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2 82-82 (1975)
Author URL
1975ASHMAN LK, LUDBROOK J, MARSHALL VR, 'PROBABILISTIC APPLICATION OF PLASMA CARCINOEMBRYONIC ANTIGEN ASSAY IN CANCER-PATIENTS', BRITISH MEDICAL JOURNAL, 2 721-724 (1975)
Author URL
CitationsWeb of Science - 12
1974ASHMAN LK, KEECH DB, 'ANALOG STUDIES OF PYRUVATE-CARBOXYLASE REACTION-MECHANISM', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 7 18-18 (1974)
Author URL
1973ASHMAN LK, WALLACE JC, KEECH DB, 'DESENSITIZATION OF PYRUVATE CARBOXYLASE AGAINST ACETYL COA STIMULATION BY CHEMICAL MODIFICATION', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 51 924-931 (1973)
DOI10.1016/0006-291X(73)90015-6Author URL
CitationsWeb of Science - 23
1973ASHMAN LK, KEECH DB, 'DESENSITIZATION OF ALLOSTERIC ACTIVATION OF PYRUVATE CARBOXYLASE', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 6 12-12 (1973)
Author URL
1972ASHMAN LK, ATWELL JL, 'AMP DEAMINASE FROM RABBIT SKELETAL-MUSCLE - EFFECT OF MONOVALENT CATIONS ON CATALYTIC ACTIVITY AND MOLECULAR-WEIGHT', BIOCHIMICA ET BIOPHYSICA ACTA, 258 618-& (1972)
DOI10.1016/0005-2744(72)90253-7Author URL
CitationsWeb of Science - 33
1972ASHMAN LK, WALLACE JC, KEECH DB, NIELSEN J, 'SHEEP KIDNEY PYRUVATE CARBOXYLASE - STUDIES ON ITS ACTIVATION BY ACETYL COENZYME-A AND CHARACTERISTICS OF ITS ACETYL COENZYME-A INDEPENDENT REACTION', JOURNAL OF BIOLOGICAL CHEMISTRY, 247 5818-& (1972)
Author URL
CitationsWeb of Science - 60
Show 183 more journal articles

Conference (26 outputs)

YearCitationAltmetricsLink
2014Bond DR, Passfield C, Cairns M, Ashman LK, Weidenhofer J, 'Posttranscriptional regulation of tetraspanins CD151 & CD9 in breast & prostate cancers', CANCER RESEARCH, San Diego, CA (2014) [E3]
DOI10.1158/1538-7445.AM2014-4364Author URL
Co-authorsMurray Cairns, Judith Weidenhofer
2013Weidenhofer J, Bond D, Copeland B, Ashman L, 'Tetraspanin protein turnover rates vary in prostate cancer cell lines', BJU INTERNATIONAL (2013) [E3]
Author URL
Co-authorsJudith Weidenhofer
2013Bond D, Cairns M, Ashman L, Weidenhofer J, 'Post-transcriptional regulation of CD151 & CD9 by miRNAs in prostate cancer', BJU INTERNATIONAL (2013) [E3]
Author URL
Co-authorsJudith Weidenhofer, Murray Cairns
2013Copeland B, Ashman L, 'Tetraspanins as potential biomarkers in prostate cancer', BJU INTERNATIONAL (2013) [E3]
Author URL
2012Bond DR, Cairns MJ, Ashman LK, Weidenhofer JC, 'Investigating micro-RNA regulation of tetraspanins CD151 and CD9 in prostate cancer', Febs Journal, Seville, Spain (2012) [E3]
Co-authorsJudith Weidenhofer, Murray Cairns
2011Moheimani F, Ashman LK, Wright MD, Jackson DE, 'Novel molecular association of ADP purinergic receptor, P2Y12 with tetraspanin superfamily member, CD151 in human platelets', JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2011)
Author URL
Co-authorsFatemeh Moheimani
2011Vilain R, Braye SG, Ashman LK, Scott R, 'BRAF and NRAS mutational status are prognostically important in thick and locally advanced cutaneous melanoma', Pigment Cell & Melanoma Research, Tampa, FL (2011) [E3]
DOI10.1111/j.1755-148X.2011.00909.x
Co-authorsRodney Scott
2011Mashkani B, Ashman LK, Griffith R, 'Implication of molecular docking in the study of structure-activity relationship of receptor tyrosine kinases inhibitors', Clinical Biochemistry, Mashhad, Iran (2011) [E3]
2011Naudin C, Weidenhofer JC, Scott R, Ashman LK, Roselli SM, 'Induction of mindin expression is associated with glomerular basement membrane damage in Cd151(-/-) mice', Nephrology, Adelaide, SA (2011) [E3]
Co-authorsJudith Weidenhofer, Rodney Scott
2010Vilain RE, Braye SG, Ashman LK, Scott R, 'Characterisation of KIT mutated melanomas: A step in the development of patient-tailored treatement for melanoma', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
Co-authorsRodney Scott
2010Verrills NM, Roberts KG, Smith AM, McDougall FK, Carpenter HC, Neviani P, et al., 'Targeting the tumour suppressor, PP2A, as a novel therapy for acute myeloid leukaemia', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
Co-authorsAlistair Sim, Nikki Verrills
2010Copeland BT, Vilain RE, Ashman LK, 'Biomarkers and regulatory proteins in prostate cancer', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
2010Vilain RE, Ashton KA, Bowden NA, Braye SG, Ashman LK, Scott RJ, 'Clinicopathological and gene expression profiling of advanced melanoma harbouring KIT and common kinase mutations', Melanoma 2010 Congress. Oral and Poster Abstracts, Sydney, NSW (2010) [E3]
Co-authorsNikola Bowden, Katie Ashton
2008Baleato RM, Guthrie PL, Gubler M-C, Ashman LK, Roselli S, 'CD151-DEFICIENT MICE DEVELOP A STRAIN-DEPENDENT KIDNEY DISEASE DUE TO ALTERATIONS OF THE GLOMERULAR BASEMENT MEMBRANE', NEPHROLOGY (2008) [E3]
Author URL
2008Mashkani B, Kim K-T, Griffith R, Ashman LK, 'Different behaviour of FDC-P1 cells expressing different FLT3 activating mutations', HMRI Conference on Translational Cancer Research Abstracts, Newcastle, NSW (2008) [E3]
2007Roberts KG, Ashman LK, Sim AT, Verrills NM, 'Regulation of protein phosphatase 2A (PP2A) B subunits by Bcr/Abl: Potential targets for chronic myeloid leukemia', AACR Meeting Abstracts Online (Abstracts of the 98th AACR Annual Meeting), Los Angeles (2007) [E3]
Co-authorsNikki Verrills, Alistair Sim
2007Roberts KG, Ashman LK, Sim ATR, Verrills NM, 'Altered expression of PP2A regulatory subunits in chronic myelogenous leukemia: Identifying targets for improved therapies', BLOOD, Atlanta, GA (2007)
Author URL
Co-authorsNikki Verrills
2005Foster R, Byrnes E, Ferrao P, Meldrum C, Ross G, Upjohn E, et al., 'A polymorphism in the transmembrane domain of c-KIT associated with pediatric mastocytosis', JOURNAL OF INVESTIGATIVE DERMATOLOGY, Perth, AUSTRALIA (2005)
Author URL
Co-authorsRodney Scott
2005Cowin AJ, Geary SM, Adams D, Wright MD, Ashman LK, 'Epidermal wound healing is defective in mice lacking tetraspanin CD151', JOURNAL OF INVESTIGATIVE DERMATOLOGY, Perth, AUSTRALIA (2005)
Author URL
2004Griffith R, Foster RC, Brown MN, Ashman LK, 'Design of inhibitors of the KIT receptor tyrosine kinase', EuroQSAR 2004 Proceedings, Instanbul, Turkey (2004) [E1]
2004Foster RC, Griffith R, Ferrao PT, Ashman LK, 'Molecular Modelling of c-Kit Kinase Domains', MM2004: 9th Molecular Modelling Workshop, Sydney, Australia (2004) [E3]
2004Geary SM, Cowin A, Fitter S, Wright MD, Ashman LK, 'Defective in vitro epidermal wound healing in mice lacking the tetraspanin CD151', JOURNAL OF INVESTIGATIVE DERMATOLOGY, Nice, FRANCE (2004)
Author URL
2003Ashman LK, Ferrao PT, Foster RC, Griffith R, 'Analysis of the Structure of the Kinase Domain of the Stem Cell Factor Receptor Tyrosin Kinase (c-Kit) - Constitutive Activation by a D816V Mutation and Inhibition by STI571', Fifth AFMC International Medicinal Chemistry Symposium AIMECS 03, Kyoto, Japan (2003) [E3]
1997Okayama Y, Kobayashi H, Ashman LK, Holgate ST, Church MK, Mori M, 'Activation of eosinophils with cytokines produced by lung mast cells', INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, TOKYO, JAPAN (1997)
Author URL
CitationsWeb of Science - 17
1995Laver JH, Abboud MR, Kawashima I, Leary AG, Ashman LK, Ogawa M, 'Characterization of c-kit expression by primitive hematopoietic progenitors in umbilical cord blood', EXPERIMENTAL HEMATOLOGY, DUSSELDORF, GERMANY (1995)
Author URL
CitationsWeb of Science - 30
1994KANAKURA Y, FURITSU T, TSUJIMURA T, BUTTERFIELD JH, ASHMAN LK, IKEDA H, et al., 'ACTIVATING MUTATIONS OF THE C-KIT PROTOONCOGENE IN A HUMAN MAST-CELL LEUKEMIA-CELL LINE', LEUKEMIA, MONTREAL, CANADA (1994)
Author URL
CitationsWeb of Science - 36
Show 23 more conferences
Edit

Grants and Funding

Summary

Number of grants66
Total funding$12,425,447

Click on a grant title below to expand the full details for that specific grant.


20131 grants / $24,596

20124 grants / $494,694

High-Resolution Isoelectric Phosphoprotein Signalling System for Signalling Research, Biomarker Validation and Drug Development – Equipment Grant$143,394

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Rick Thorne, Professor Xu Dong Zhang, Professor Hubert Hondermarck, Conjoint Professor Stephen Ackland, Doctor Lisa Lincz, Doctor Jennette Sakoff, Emeritus Professor Leonie Ashman
SchemeProject Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200555
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Microscopic illumination system for advanced fluorescent protein technology$34,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Rick Thorne, Professor Xu Dong Zhang, Conjoint Associate Professor Murray Cairns, Doctor Nikki Verrills, Doctor Charles De Bock, Doctor Jude Weidenhofer, Doctor Severine Roselli, Doctor Kathryn Skelding, Emeritus Professor Leonie Ashman, Professor Hubert Hondermarck
SchemeEquipment Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100983
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Does Ubiquitination control the altered expression of tetraspanin proteins in Breast Cancer?$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Jude Weidenhofer, Emeritus Professor Leonie Ashman, Professor Hubert Hondermarck
SchemeProject Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200169
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20113 grants / $2,093,333

Hunter Translational Cancer Research Unit$1,693,333

Funding body: Cancer Institute NSW

Funding bodyCancer Institute NSW
Project TeamConjoint Professor Stephen Ackland, Emeritus Professor Leonie Ashman, Professor John Forbes, Laureate Professor Robert Sanson-Fisher, Conjoint Associate Professor Anthony Proietto, Professor Rodney Scott
SchemeTranslational Cancer Research Unit
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100545
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Identifying the mechanisms underlying altered expression and mode of action of tetraspanins CD151 and CD9 in metastasis: progression to targeted treatment for prostate cancer$375,000

Funding body: Prostate Cancer Foundation of Australia

Funding bodyProstate Cancer Foundation of Australia
Project TeamEmeritus Professor Leonie Ashman, Doctor Jude Weidenhofer
SchemeProject Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1000863
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Investigation of the function of CD151 in the glomerular filtration barrier and identification of genetic modifiers of glomerular diseases$25,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Severine Roselli, Doctor Jude Weidenhofer, Emeritus Professor Leonie Ashman
SchemeNear Miss Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1001053
Type Of FundingInternal
CategoryINTE
UONY

20104 grants / $1,103,071

HMRI MRSP Infrastructure Grant (10-11) - CANCER$504,071

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamEmeritus Professor Leonie Ashman, Conjoint Professor Stephen Ackland
SchemeNSW MRSP Infrastructure Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG1100269
Type Of FundingOther Public Sector - State
Category2OPS
UONY

ABI 7500 Real Time PCR System $34,000

Funding body: NHMRC (National Health & Medical Research Council)

20099 grants / $1,669,011

Tetraspanin proteins in prostate cancer progression and prognosis$341,000

Funding body: Cancer Council NSW

Funding bodyCancer Council NSW
Project TeamEmeritus Professor Leonie Ashman, Doctor Nikki Verrills, Conjoint Professor Jim Denham
SchemeResearch Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0188877
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

MRSP Infrastructure (09-10) Cancer$283,916

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamEmeritus Professor Leonie Ashman, Conjoint Professor Stephen Ackland
SchemeNSW MRSP Infrastructure Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0900172
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Confocal Laser Scanning Microscopy for Live Cell Imaging$275,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamConjoint Professor Keith Jones, Professor Eileen McLaughlin, Laureate Professor John Aitken, Conjoint Professor Ray Rose, Emeritus Professor John Patrick, Conjoint Professor Christina Offler, Associate Professor David McCurdy, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Professor Dirk Van Helden, Doctor Nikki Verrills, Associate Professor Brett Nixon, Doctor Shaun Roman, Associate Professor Yong-Ling Ruan, Doctor Rick Thorne, Professor Mike Calford
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189038
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

IVIS Lumina II fluorescence and bioluminescence imager for in vivo analysis of tumour growth and metastasis in mouse models$153,200

Funding body: Cancer Institute NSW

Funding bodyCancer Institute NSW
Project TeamEmeritus Professor Leonie Ashman
SchemeResearch Equipment Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189634
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Study of c-KIT mutations in familial gastrointestinal stromal tumours and malignant melanoma$44,720

Funding body: Pfizer Australia

Funding bodyPfizer Australia
Project TeamMr Ricardo Vilain, Professor Rodney Scott, Emeritus Professor Leonie Ashman
SchemeCancer Research Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189919
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Identification of genetic modifiers of kidney disease$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Severine Roselli, Emeritus Professor Leonie Ashman, Professor Rodney Scott
SchemeProject Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189793
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

3rd European Conference on Tetraspanins, Paris, 10-11 September 2009$1,175

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Leonie Ashman
SchemeTravel Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0900245
Type Of FundingInternal
CategoryINTE
UONY

20084 grants / $1,408,790

HMRI Cancer Research Program - MRSP Infrastructure$1,031,290

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Professor Stephen Ackland, Emeritus Professor Leonie Ashman, Professor John Forbes, Conjoint Professor Jim Denham, Conjoint Professor Peter Hersey, Professor Gordon Burns, Professor Adam McCluskey, Doctor Nikki Verrills
SchemeNSW MRSP Infrastructure Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188622
Type Of FundingOther Public Sector - State
Category2OPS
UONY

PP2A: a novel target for leukaemia therapy$300,000

Funding body: Cancer Council NSW

Funding bodyCancer Council NSW
Project TeamDoctor Nikki Verrills, Emeritus Professor Leonie Ashman, Professor Alistair Sim, Associate Professor Danilo Perrotti, Assoc. Prof Timothy Hughes, Dr David Thomas
SchemeResearch Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0187694
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Role of tetraspanin proteins in human breast and prostate cancer$75,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamEmeritus Professor Leonie Ashman, Doctor Severine Roselli
SchemeMary Minto Sawyer Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188187
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

FASEB Summer Research conference $2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Leonie Ashman
SchemeTravel Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0189020
Type Of FundingInternal
CategoryINTE
UONY

20076 grants / $418,000

FACSAria - Fluorescence activated cell sorter$300,000

Funding body: Cancer Institute NSW

Funding bodyCancer Institute NSW
Project TeamDoctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
SchemeResearch Infrastructure Grants
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187666
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

HMRI Contribution toward FACSAria - Fluorescence activated cell sorter$52,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
SchemeEquipment Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188207
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Activity of kinase inhibitors on mutant forms of c-KIT in GIST and AML$27,500

Funding body: Novartis Pharmaceuticals Australia Pty Limited

Funding bodyNovartis Pharmaceuticals Australia Pty Limited
Project TeamEmeritus Professor Leonie Ashman
SchemeProject Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0188467
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Polymerase Chain Reaction (PCR) machine and Spectrophotometer$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Leonie Ashman, Professor Alistair Sim, Doctor Nikki Verrills
SchemeEquipment Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0188195
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Regulation of cancer cell behaviour by tetraspanin molecular complexes$16,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Judith Scott, Emeritus Professor Leonie Ashman
SchemeProject Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187242
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Beatson International Cancer Conference Molecular Cancer Thereapies: new challenges and horizons, Caledonian University, Glasgow, UK, 17/6/2007 - 20/6/2007$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Leonie Ashman
SchemeTravel Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187736
Type Of FundingInternal
CategoryINTE
UONY

20064 grants / $1,418,962

2006 Research Fellowship$776,824

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Leonie Ashman
SchemeResearch Fellowships
RoleLead
Funding Start2006
Funding Finish2006
GNoG0185093
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Structural studies of the binding of clinically relevant small-molecule injibitors to wildtype and mutant receptor tyrosine kinases$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Associate Professor Renate Griffith, Emeritus Professor Leonie Ashman
SchemePilot Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186710
Type Of FundingInternal
CategoryINTE
UONY

BioRad Mini-PROTEAN3 Electrophoresis system$995

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamEmeritus Professor Leonie Ashman, Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Professor Judith Scott, Professor Alistair Sim, Doctor Nikki Verrills
SchemeEquipment Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0187280
Type Of FundingNot Known
CategoryUNKN
UONY

20059 grants / $1,362,590

Role of the tetraspanin CD151 in epithelial biology and cancer$447,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Leonie Ashman
SchemeProject Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0183903
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

CD151 and functional overlap in tetraspanins$219,303

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamEmeritus Professor Leonie Ashman, Dr Mark Wright
SchemeDiscovery Projects
RoleLead
Funding Start2005
Funding Finish2005
GNoG0184421
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Protein kinase inhibitors for the treatment of acute myeloid leukaemia$217,500

Funding body: Anthony Rothe Memorial Trust

Funding bodyAnthony Rothe Memorial Trust
Project TeamEmeritus Professor Leonie Ashman
SchemeResearch Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0184574
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Mechanisms of drug resistance in acute myeloid leukaemia$156,200

Funding body: Leukaemia Foundation of NSW

Funding bodyLeukaemia Foundation of NSW
Project TeamEmeritus Professor Leonie Ashman
SchemeResearch Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0184615
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

2005 RIBG allocation$89,711

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Leonie Ashman
SchemeResearch Infrastructure Block Grant (RIBG)
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185800
Type Of FundingInternal
CategoryINTE
UONY

How the cell surface protein, CD151 promotes invasive behaviour in breast cancer$15,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamEmeritus Professor Leonie Ashman
SchemeMary Minto Sawyer Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185658
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Oolemmal receptors - the role of the tetraspanin CD151 in sperm-egg fusion$7,537

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin, Emeritus Professor Leonie Ashman
SchemeProject Grant
RoleInvestigator
Funding Start2005
Funding Finish2005
GNoG0184625
Type Of FundingInternal
CategoryINTE
UONY

International Tetraspanins mini-symposium, June 30-July 1 2005, Federation of American Societies for Experimental Biology Summer Research Conference 16-21 July 2005$2,400

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Leonie Ashman
SchemeTravel Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185496
Type Of FundingInternal
CategoryINTE
UONY

20045 grants / $233,136

Biacore3000-Expansion of Proteomics Facility$187,341

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Alistair Sim, Laureate Professor John Aitken, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Emeritus Professor Leonie Ashman, Professor Roger Smith, Professor Gordon Burns, Professor Adam McCluskey, Associate Professor Paul Tooney, Dr Fraser Ross, Conjoint Professor Ray Rose
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183030
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

New drugs targeting protein kinases$17,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamEmeritus Professor Leonie Ashman, Professor Adam McCluskey
SchemeResearch Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0183751
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Characterisation of a novel recepto-mediated signal transduction pathway in human spermatozoa.$14,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Brett Nixon, Emeritus Professor Leonie Ashman
SchemeProject Grant
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183444
Type Of FundingInternal
CategoryINTE
UONY

Is CD151 a co-receptor for human papilloma virus$12,395

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Leonie Ashman
SchemeProject Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0183418
Type Of FundingInternal
CategoryINTE
UONY

FASEB Summer Research Conference: Advances in Tetraspanin Research, 19-24 June 2004, USA$2,400

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Leonie Ashman
SchemeTravel Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0184098
Type Of FundingInternal
CategoryINTE
UONY

20033 grants / $34,900

Detection of mutations in c-kit in paediatric mastocytosis patient samples and structural analysis of the interaction between the D816VKit mutant and inhibitor$17,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamEmeritus Professor Leonie Ashman, Dr Petranel Ferrao
SchemeResearch Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182632
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Molecular basis of cellular localisation of a cell membrane protein, CD151.$15,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Leonie Ashman
SchemeProject Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182464
Type Of FundingInternal
CategoryINTE
UONY

Beatson Conference: Cell signalling and Cancer, Glasgow, Scotland 6-9 July, 2003$2,400

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Leonie Ashman
SchemeTravel Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0183163
Type Of FundingInternal
CategoryINTE
UONY

20029 grants / $1,776,206

Proteomic and Genomic Analysis Facility.$473,332

Funding body: Wellcome Trust

Funding bodyWellcome Trust
Project TeamProfessor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Professor Rodney Scott, Emeritus Professor Leonie Ashman
SchemeMajor Equipment Award
RoleInvestigator
Funding Start2002
Funding Finish2002
GNoG0181527
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

c-Kit signalling and cellular responses in haemopoietic cells$470,250

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Leonie Ashman
SchemeResearch Fellowships
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181693
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

c-Kit signalling and cellular responses in haemopoietic cells$377,024

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Leonie Ashman
SchemeProject Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181692
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Use of retroviral libraries to characterise mechanisms of drug resistance in leukaemia$240,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDr Petranel Ferrao, Emeritus Professor Leonie Ashman, Dr A Zannettino, Dr T Hughes
SchemeProject Grant
RoleInvestigator
Funding Start2002
Funding Finish2002
GNoG0181690
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Molecular determinants of subcellular localisation and function of the transmembrane 4 superfamily protein, PETA-3$107,512

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Leonie Ashman
SchemeProject Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181691
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Role of PETA-3/CD151 in epithelial cancer invasion and metastasis.$70,008

Funding body: Cancer Council NSW

Funding bodyCancer Council NSW
Project TeamEmeritus Professor Leonie Ashman
SchemeResearch Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181686
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Peltier Thermal Cycler and associated equipment essential for establishing cDNA Retroviral Libraries$21,315

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Leonie Ashman, Dr Petranel Ferrao, Professor Gordon Burns, Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Dirk Van Helden, Dr Perry Hartfield
SchemeEquipment Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181919
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

A tissue culture system for antibody production$14,265

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Leonie Ashman
SchemeNew Staff Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0182574
Type Of FundingInternal
CategoryINTE
UONY

FASEB Summer Research Conference: 2nd International Conf. on Tetraspanin Proteins Tuscan, AZ, USA, 15 - 20 June, 2002$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Leonie Ashman
SchemeTravel Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181991
Type Of FundingInternal
CategoryINTE
UONY

20015 grants / $388,158

c-KIT signalling and cellular responses in haemopoietic cells.$125,688

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeProject
RoleLead
Funding Start2001
Funding Finish2001
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

Molecular determinants of subcellular localisation and function of the transmembrane 4 superfamily protein, PETA-3.$105,162

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeProject
RoleLead
Funding Start2001
Funding Finish2001
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

c-KIT signalling and cellular responses in haemopoietic cells.$85,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeResearch Fellowships
RoleLead
Funding Start2001
Funding Finish2001
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

Role of PETA-3/CD151 in epithelial cancer invasion and metastasis.$60,308

Funding body: Cancer Council SA

Funding bodyCancer Council SA
Project Team
SchemeProject
RoleLead
Funding Start2001
Funding Finish2001
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

Use of retroviral expression libraries to characterise mechanisms of drug resistance in leukaemia, $12,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project Team
SchemeProject
RoleInvestigator
Funding Start2001
Funding Finish2001
GNo
Type Of FundingNot Known
CategoryUNKN
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2011The Tetraspanin CD151's Role in the Kidney and Mapping of Genetic Modifiers of Glomerular Diseases
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2011Post-Transcriptional Regulation of Tetraspanins CD151 and CD9 by Micro-RNA's in Prostate and Breast Cancers
Medical Science, Faculty of Health and Medicine
Co-Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2014Targeting PP2A Activation as a Novel Therapeutic Strategy for Receptor Tyrosine Kinase Driven Leukemia
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2013Tetraspanins as Biomarkers and Causative Proteins in Prostate Cancer
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2013Activating Kinase Mutations in Melanoma
Health, Faculty of Health and Medicine
Co-Supervisor
2010Regulation of the Tumour Suppressor PP2A by Oncogenic Tyrosine Kinases
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2010Small Molecule Inhibitors for Type III Receptor Tyrosine Kinases
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2009c-KIT Polymorphisms in Pediatric Mastocytosis and Comparative Analysis of Wild Type c-KIT and the Asp816Val Mutant
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2007The Role of the Tetraspanin CD151 in Integrin/Growth Factor Receptor Complexes and Its Influence on Cancer Cell Behaviour
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2005Resistance to imatinib (STI 571) conferred by point mutations of Kit and BCR/ABL
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2004Subcellular Localisation and Internalisation of the Tetraspanin, CD151: Role of the Cytoplasmic Domains
Medical Science, Faculty of Health and Medicine
Sole Supervisor
2003Molecular and Cellular Studies of Isoforms of c-KIT
Biochemistry & Cell Biology, University of Adelaide
Principal Supervisor
2002Receptor tyrosine kinase c-KIT:signal transduction and biological response
Behavioural Science N.E.C., University of Adelaide
Sole Supervisor
2001Function of the soluble c-KIT extracellular domain
Biochemistry & Cell Biology, University of Adelaide
Sole Supervisor
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Emeritus Professor Leonie Ashman

Positions

Conjoint Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Emeritus Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Medical Biochemistry

Contact Details

Emailleonie.ashman@newcastle.edu.au
Phone(08) 8376 9069
Mobile0419840829
Fax-

Office

Room-
Building-
LocationAdelaide SA

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