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Emeritus Professor Leonie Ashman

Conjoint Professor

School of Biomedical Sciences and Pharmacy (Medical Biochemistry)

Career Summary

Biography

Professor Ashman is a NHMRC Principal Research Fellow and Gladys Brawn Professorial Fellow. She came to the University of Newcastle in 2002 from the Hanson Centre for Cancer Research and the University of Adelaide. In her career spanning 35 years she has published 150 papers in refereed international journals and conference proceedings. Career highlights include identification at the protein level of the receptor tyrosine kinase c-KIT, publication of the first monoclonal antibody to it, and the first description of c-KIT expression by haemopoietic progenitor cells in bone marrow. She has an ongoing interest in the role of mutant c-KIT in acute myeloid leukaemia and other cancers and in new drugs that target this receptor. Prof Ashman's group also identified a novel tetraspanin protein, CD151, cloned the gene, and generated the first CD151 knock-out mice. Work in this and other laboratories has shown that the CD151 protein modifies cell adhesion and migration and plays an important role in the spread (metastasis) of cancer.

Research Expertise

I was trained as a biochemist but worked for many years in immunology. In now consider myself as a cell and molecular biologist. The underlying theme of my research has always been cancer, its cellular and molecular biology and development of novel approaches to diagnosis and treatment. Major themes have been haemopoiesis and leukaemia, regulation of cellular behaviour by cell surface receptors, cellular signalling and development of novel targetted therapeutics.

Teaching Expertise
While I have always been employed in "Research Only" positions I have contributed extensively to teaching both at the University of Adelaide and the University of Newcastle. Currently I teach into the B Biomed Sci program in my areas of research expertise (Cancer biology and novel drug development).

Administrative Expertise
Initiated and coordinated B Health Sci (Hons) program in Experimental Medicine at Adelaide University, Member, Graduate Studies Committee and Board of Research Education and Development at Adelaide University Elected Staff Representative, Hanson Centre Executive Member, Hanson Institute Strategic Advisory Committee Member, NHMRC Research Fellowships Advisory Panel, 2001, 2002. Member NHMRC Grant Review panel, 2005, 2006. At University of Newcastle: Member, Faculty of Health Research Management Committee (2002, 2003). Research Portfolio Committee, 2004 (casual vacancy) Member of multiple appointments committess and grant review panels. 


Qualifications

  • PhD, University of Adelaide
  • Bachelor of Science (Honours), Flinders University

Keywords

  • Cancer Biology
  • Cell and Molecular biology of cancer

Fields of Research

Code Description Percentage
110199 Medical Biochemistry and Metabolomics not elsewhere classified 10
111299 Oncology and Carcinogenesis not elsewhere classified 30
060199 Biochemistry and Cell Biology not elsewhere classified 60

Professional Experience

Academic appointment

Dates Title Organisation / Department
1/01/2006 - 1/12/2011 Fellow University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/2004 - 1/12/2008 Joint Convenor Hunter Medical Research Institute International Conferences on Translational Cancer Research
Australia
1/04/1993 - 1/12/2001 Affiliate Associate Professor The University of Adelaide
Department of Medicine
Australia
1/10/1992 - 1/12/2001 NHMRC Principal Research Fellow

Haematology

Institute of Medical and Veterinary Science, Adelaide
Hanson Centre for Cancer Research
Australia

Membership

Dates Title Organisation / Department
1/01/2005 - 1/12/2006 Member - Grant Review Panel - Cell Biology NHMRC (National Health & Medical Research Council)
Australia
1/01/2001 - 1/12/2002 Member - Research Fellowship Advisory Panel A NHMRC (National Health & Medical Research Council)
Australia

Invitations

Participant

Year Title / Rationale
2004 Summer Research Conference: tetraspanins
Organisation: Federation of American Societies of Experimental Biology Description: I was invited speaker and session chair at all three biennial conferences in this field (2002, 2004, 2006). This is the most important international conference in this specialist field.
2001 Glivec Solid Tumour Advisory Board
Organisation: Novartis Pharma Description: Expert consultant/ member of this select panel to adivse on the cell biology and potential clinical applications of an new protein kinase inhibitory drug.
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

Year Citation Altmetrics Link
2013 Ashman LK, Zoller M, 'Tetraspanins in Cancer', Tetraspanins, Springer, Dordrecht 257-298 (2013) [B1]
DOI 10.1007/978-94-007-6070-7_11

Journal article (186 outputs)

Year Citation Altmetrics Link
2014 Mashkani B, Griffith R, Ashman L, 'Differences in growth promotion, drug response and intracellular protein trafficking of FLT3 mutants', Iranian Journal of Basic Medical Sciences, 17 867-873 (2014) [C1]
2014 Roselli S, Kahl RGS, Copeland BT, Naylor MJ, Weidenhofer J, Muller WJ, Ashman LK, 'Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model', BMC Cancer, 14 (2014) [C1]

Background: Tetraspanins are transmembrane proteins that serve as scaffolds for multiprotein complexes containing, for example, integrins, growth factor receptors and matrix metal... [more]

Background: Tetraspanins are transmembrane proteins that serve as scaffolds for multiprotein complexes containing, for example, integrins, growth factor receptors and matrix metalloproteases, and modify their functions in cell adhesion, migration and transmembrane signaling. CD151 is part of the tetraspanin family and it forms tight complexes with ß1 and ß4 integrins, both of which have been shown to be required for tumorigenesis and/or metastasis in transgenic mouse models of breast cancer. High levels of the tetraspanin CD151 have been linked to poor patient outcome in several human cancers including breast cancer. In addition, CD151 has been implicated as a promoter of tumor angiogenesis and metastasis in various model systems.Methods: Here we investigated the effect of Cd151 deletion on mammary tumorigenesis by crossing Cd151-deficient mice with a spontaneously metastasising transgenic model of breast cancer induced by the polyoma middle T antigen (PyMT) driven by the murine mammary tumor virus promoter (MMTV).Results: Cd151 deletion did not affect the normal development and differentiation of the mammary gland. While there was a trend towards delayed tumor onset in Cd151 -/- PyMT mice compared to Cd151 +/+ PyMT littermate controls, this result was only approaching significance (Log-rank test P-value =0.0536). Interestingly, Cd151 deletion resulted in significantly reduced numbers and size of primary tumors but did not appear to affect the number or size of metastases in the MMTV/PyMT mice. Intriguingly, no differences in the expression of markers of cell proliferation, apoptosis and blood vessel density was observed in the primary tumors.Conclusion: The findings from this study provide additional evidence that CD151 acts to enhance tumor formation initiated by a range of oncogenes and strongly support its relevance as a potential therapeutic target to delay breast cancer progression. © 2014 Roselli et al.; licensee BioMed Central Ltd.

DOI 10.1186/1471-2407-14-509
Citations Scopus - 1
Co-authors Judith Weidenhofer
2013 Copeland BT, Bowman MJ, Boucheix C, Ashman LK, 'Knockout of the tetraspanin Cd9 in the TRAMP model of de novo prostate cancer increases spontaneous metastases in an organ-specific manner', International Journal of Cancer, 133 1803-1812 (2013) [C1]

Prostate cancer is an extremely heterogeneous disease; patients that do progress to late-stage metastatic prostate cancer have limited treatment options, mostly palliative. Molecu... [more]

Prostate cancer is an extremely heterogeneous disease; patients that do progress to late-stage metastatic prostate cancer have limited treatment options, mostly palliative. Molecules involved in the metastatic cascade may prove beneficial in stratifying patients to assign appropriate treatment modalities and may also prove to be therapeutic antimetastatic targets. The tetraspanin group of molecules are integral membrane proteins that associate with motility-related proteins such as integrins. Clinical studies have mostly shown that reduced expression levels of the tetraspanin CD9 are correlated with tumour progression in a range of cancers. Furthermore, functional studies have shown CD9 to be involved in cell motility and adhesion and that it may influence metastasis. The effects of endogenous CD9 on prostate cancer initiation and progression were analysed by crossing a Cd9-/- (KO) murine model with a model of de novo developing and spontaneously metastasising prostate cancer, namely the transgenic adenocarcinoma of mouse prostate model. Our study demonstrates for the first time that ablation of Cd9 had no detectable effect on de novo primary tumour onset, but did significantly increase metastasis to the liver but not the lungs. What's new? The ability to distinguish between prostate tumors that are more or less likely to spread could facilitate decisions regarding treatment options for patients. A promising marker for such distinction is the tetraspanin protein CD9, which in experimental studies has been linked to metastasis. Here, Cd9 genetic ablation in the well-characterized transgenic adenocarcinoma of mouse prostate (TRAMP) model reveals an association between loss of Cd9 expression and increased incidence of metastases to the liver but not the lung. In contrast, Cd9 ablation did not affect primary prostate tumor initiation. The findings suggest that Cd9 acts as a suppressor of metastasis. Copyright © 2013 UICC.

DOI 10.1002/ijc.28204
Citations Scopus - 5Web of Science - 4
2013 Ashman LK, 'Renal disease as a potential compounding factor in carcinogenesis experiments with Cd151-null mice', ONCOGENE, 32 4457-4457 (2013) [C3]
DOI 10.1038/onc.2013.73
Citations Scopus - 1Web of Science - 1
2013 Mashkani B, Odell AF, Byrnes EM, Griffith R, Ashman LK, 'Expression of biologically active human colony stimulating factor-1 in Pichia pastoris', Protein Expression and Purification, 88 93-97 (2013) [C1]
DOI 10.1016/j.pep.2012.11.017
Citations Scopus - 1Web of Science - 1
2013 Ashman LK, Griffith R, 'Therapeutic targeting of c-KIT in cancer', EXPERT OPINION ON INVESTIGATIONAL DRUGS, 22 103-115 (2013) [C1]
DOI 10.1517/13543784.2013.740010
Citations Scopus - 28Web of Science - 26
2013 Copeland BT, Bowman MJ, Ashman LK, 'Genetic Ablation of the Tetraspanin CD151 Reduces Spontaneous Metastatic Spread of Prostate Cancer in the TRAMP Model', MOLECULAR CANCER RESEARCH, 11 95-105 (2013) [C1]
DOI 10.1158/1541-7786.MCR-12-0468
Citations Scopus - 12Web of Science - 11
2011 Ashman LK, 'Cell line models identify different sensitivity of mutant forms of c-KIT to kinase inhibitory drugs and predict the response of patients to therapy', Molecular Cancer Therapeutics, 10 2032-2033 (2011) [C3]
DOI 10.1158/1535-7163.MCT-11-0706
2011 Vilain RE, Dudding TE, Braye SG, Groombridge C, Meldrum C, Spigelman AD, et al., 'Can a familial gastrointestinal tumour syndrome be allelic with Waardenburg syndrome?', Clinical Genetics, 79 554-560 (2011) [C3]
DOI 10.1111/j.1399-0004.2010.01489.x
Citations Scopus - 4Web of Science - 2
Co-authors Stephen Ackland, Rodney Scott
2010 Roberts KG, Smith AM, McDougall FK, Carpenter HC, Horan MP, Neviani P, et al., 'Essential requirement for PP2A inhibition by the oncogenic receptor c-KIT suggests PP2A reactivation as a strategy to treat c-KIT+ cancers', Cancer Research, 70 5438-5447 (2010) [C1]
DOI 10.1158/0008-5472.CAN-09-2544
Citations Scopus - 57Web of Science - 52
Co-authors Nikki Verrills, Alistair Sim
2010 Mashkani B, Griffith R, Ashman LK, 'Colony stimulating factor-1 receptor as a target for small molecule inhibitors', Bioorganic & Medicinal Chemistry, 18 1789-1797 (2010) [C1]
DOI 10.1016/j.bmc.2010.01.056
Citations Scopus - 14Web of Science - 13
2010 Ang J, Fang B-L, Ashman LK, Frauman AG, 'The migration and invasion of human prostate cancer cell lines involves CD151 expression', Oncology Reports, 24 1593-1597 (2010) [C1]
DOI 10.3892/or_00001022
Citations Scopus - 12Web of Science - 12
2009 Orlowski E, Chand R, Yip J, Wong C, Goschnick MW, Wright MD, et al., 'A platelet tetraspanin superfamily member, CD151, is required for regulation of thrombus growth and stability in vivo', Journal of Thrombosis and Haemostasis, 7 2074-2084 (2009) [C1]
DOI 10.1111/j.1538-7836.2009.03612.x
Citations Scopus - 20Web of Science - 17
2009 Weidenhofer JC, Ashman LK, 'CD151 (CD151 molecule (Raph blood group))', Atlas of Genetics and Cytogenetics in Oncology and Haematology, - - (2009) [C1]
Co-authors Judith Weidenhofer
2009 Sheng K-C, Van Spriel AB, Gartlan KH, Sofi M, Apostolopoulos V, Ashman LK, Wright MD, 'Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC', European Journal of Immunology, 39 50-55 (2009) [C1]
DOI 10.1002/eji.200838798
Citations Scopus - 28Web of Science - 24
2009 Protty MB, Watkins NA, Colombo D, Thomas SG, Heath VL, Herbert JMJ, et al., 'Identification of Tspan9 as a novel platelet tetraspanin and the collagen receptor GPVI as a component of tetraspanin microdomains', Biochemical Journal, 417 391-400 (2009) [C1]
DOI 10.1042/bj20081126
Citations Scopus - 21Web of Science - 21
2008 Baleato R, Guthrie PL, Gubler M-C, Ashman LK, Roselli SM, 'Deletion of Cd151 results in a strain-dependent glomerular disease due to severe alterations of the glomerular basement membrane', American Journal of Pathology, 173 927-937 (2008) [C1]
DOI 10.2353/ajpath.2008.071149
Citations Scopus - 51Web of Science - 47
2008 Foster RC, Byrnes EM, Meldrum C, Griffith R, Ross G, Upjohn E, et al., 'Association of paediatric mastocytosis with a polymorphism resulting in an amino acid substitution (M541L) in the transmembrane domain of c-KIT', British Journal of Dermatology, 159 1160-1169 (2008) [C1]
DOI 10.1111/j.1365-2133.2008.08827.x
Citations Scopus - 27Web of Science - 23
Co-authors Rodney Scott
2008 Geary SM, Cowin AJ, Copeland BT, Baleato R, Miyazaki K, Ashman LK, 'The role of the tetraspanin CD151 in primary keratinocyte and fibroblast functions: Implications for wound healing', Experimental Cell Research, 314 2165-2175 (2008) [C1]
DOI 10.1016/j.yexcr.2008.04.011
Citations Scopus - 18Web of Science - 15
2008 Baldwin G, Novitskaya V, Sadej R, Pochec E, Litynska A, Hartmann C, et al., 'Tetraspanin CD151 regulates glycosylation of alpha 3 beta 1 integrin', Journal of Biological Chemistry, 283 35445-35454 (2008) [C1]
DOI 10.1074/jbc.m806394200
Citations Scopus - 31Web of Science - 28
2008 Yamada M, Tamura Y, Sanzen N, Sato-Nishiuchi R, Hasegawa H, Ashman LK, et al., 'Probing the interaction of tetraspanin CD151 with integrin alpha 3 beta 1 using a panel of monoclonal antibodies with distinct reactivities toward the CD151-integrin alpha 3 beta 1 complex', Biochemical Journal, 415 417-427 (2008) [C1]
DOI 10.1042/bj20071625
Citations Scopus - 10Web of Science - 10
2007 Young SM, Cambareri AC, Odell AF, Geary SM, Ashman LK, 'Early myeloid cells expressing c-KIT isoforms differ in signal transduction, survival and chemotactic responses to Stem Cell Factor', Cellular Signalling, 19 2572-2581 (2007) [C1]
DOI 10.1016/j.cellsig.2007.08.004
Citations Scopus - 9Web of Science - 10
2007 Roberts KG, Odell AF, Byrnes EM, Baleato R, Griffith R, Lyons AB, Ashman LK, 'Resistance to c-KIT kinase inhibitors conferred by V654A mutation', Molecular Cancer Therapeutics, 6 1159-1166 (2007) [C1]
DOI 10.1158/1535-7163.mct-06-0641
Citations Scopus - 47Web of Science - 46
2006 Cowin AJ, Adams D, Geary SM, Wright MD, Jones JCR, Ashman LK, 'Wound healing is defective in mice lacking tetraspanin CD151', Journal of Investigative Dermatology, 126 680-689 (2006) [C1]
DOI 10.1038/sj.jid.5700142
Citations Scopus - 55Web of Science - 53
2006 Young SM, Cambareri AC, Ashman LK, 'Role of c-KIT expression level and phosphatidylinositol 3-kinase activation in survival and proliferative responses of early myeloid cells', Cellular Signalling, 18 608-620 (2006) [C1]
DOI 10.1016/j.cellsig.2005.06.005
Citations Scopus - 13Web of Science - 13
2006 Griffith R, Brown MN, McCluskey A, Ashman LK, 'Small molecule inhibitors of protein kinases in cancer - How to overcome resistance', Mini-Reviews in Medicinal Chemistry, 6 1101-1110 (2006) [C1]
DOI 10.2174/138955706778560184
Citations Scopus - 5Web of Science - 4
Co-authors Adam Mccluskey
2006 Winterwood NE, Varzavand A, Meland MN, Ashman LK, Stipp CS, 'A critical role for tetraspanin CD151 in alpha 381 and alpha 684 integrin-dependent tumor cell functions on Laminin-5', Molecular Biology of the Cell, 17 2707-2721 (2006) [C1]
DOI 10.1091/mbc.E05-11-1042
Citations Scopus - 82Web of Science - 81
2005 Nixon B, Paul JW, Spiller CM, Attwell-Heap AG, Ashman LK, Aitken RJ, 'Evidence for the involvement of PECAM-1 in a receptor mediated signal-transduction pathway regulating capacitation-associated tyrosine phosphorylation in human spermatozoa', Journal of Cell Science, 118 4865-4877 (2005) [C1]
DOI 10.1242/jcs.02604
Citations Scopus - 13Web of Science - 13
Co-authors John Aitken, Jonathan Paul, Brett Nixon
2005 Ang J, Lijovic M, Frauman AG, Ashman LK, Kan K, 'Low grade primary prostate cancer (vol 13, pg 1717, 2004)', CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 14 553-553 (2005)
Citations Web of Science - 1
2005 Ang J, Lijovic M, Frauman AG, Ashman LK, Kahn K, 'Erratum: CD151 protein expression predicts the clinical outcome of low-grade primary prostate cancer better than histologic grading: A new prognostic indicator? (Cancer Epidemiology Biomarkers and Prevention (November 2004) 13, 11 (1717-1721))', Cancer Epidemiology Biomarkers and Prevention, 14 553-553 (2005)
2005 Gesierich S, Paret C, Hildebrand D, Weitz J, Zgraggen K, Schmitz-Winnenthal FH, et al., 'Colocalization of the tetraspanins, CO-029 and CD151, with integrins in human pancreatic adenocarcinoma: Impact on cell motility', Clinical Cancer Research, 11 2840-2852 (2005) [C1]
DOI 10.1158/1078-0432.CCR-04-1935
Citations Scopus - 70Web of Science - 64
2004 Lau L-M, Wee JL, Wright MD, Moseley GW, Hogarth PM, Ashman LK, Jackson DE, 'The tetraspanin superfamily member CD151 regulates outside-in integrin alpha IIb Beta 3 signaling and platelet function', Blood, 104 2368-2375 (2004) [C1]
DOI 10.1182/blood-2003-12-4430
Citations Web of Science - 64
2004 Moseley GW, Lau L-M, Sheng K-C, Apostolopoulos V, Stanley EG, Jackson DE, et al., 'Characterization of Mice Lacking the Tetraspanin Superfamily Member CD151', Molecular and Cellular Biology, 24 5978-5988 (2004) [C1]
DOI 10.1128/MCB.24.13.5978-5988.2004
Citations Scopus - 107Web of Science - 105
2004 Ang J, Lijovic M, Ashman LK, Kan K, Frauman A, 'CD151 Protein Expression Predicts the Clinical Outcome of Low-Grade Primary Prostate Cancer Better than Histologic Grading: A New Prognostic Indicator?', Cancer Epidemiology, Biomarkers & Prevention, 13 1717-1721 (2004) [C1]
Citations Scopus - 70Web of Science - 65
2004 Foster RC, Griffith R, Ferrao PT, Ashman LK, 'Molecular basis of the constitutive activity and STI571 resistance of Asp816Val mutant KIT receptor tyrosine kinase', Journal of Molecular Graphics and Modelling, 23 139-152 (2004) [C1]
DOI 10.1016/j.jmgm.2004.04.003
Citations Scopus - 36Web of Science - 33
2003 Charrin S, Manie S, Billard M, Ashman LK, Gerlier D, Boucheix C, Rubinstein E, 'Multiple levels of interactions within the tetraspanin web', Biochemical and Biophysical Research Communications, 304 107-112 (2003) [C1]
DOI 10.1016/S0006-291X(03)00545-X
Citations Web of Science - 76
2003 Thai LM, Ashman LK, Harbour SN, Hogarth M, Jackson D, 'Physical proximity and functional interplay of PECAM-1 with the Fc receptor FcyRIIa on the platelet plasma membrane', Blood, 102 3637-3645 (2003) [C1]
DOI 10.1182/blood-2003-02-0496
Citations Web of Science - 23
2003 Ferrao PT, Frost MJ, Siah SP, Ashman LK, 'Overexpression of P-glycoprotein in K562 cells does not confer resistance to the growth inhibitory effects of imatinib (STI571) in vitro', Blood, 102 4499-4503 (2003) [C1]
DOI 10.1182/blood-2003-01-0083
Citations Scopus - 70Web of Science - 59
2003 Voytyuk O, Lennartsson J, Mogi A, Caruana G, Courtneidge S, Ashman LK, Ronnstrand L, 'Src Family Kinases Are Involved in the Differential Signaling from Two Splice Forms of c-Kit', The Journal of Biological Chemistry, 278 9159-9166 (2003) [C1]
DOI 10.1074/jbc.M211726200
Citations Scopus - 55Web of Science - 53
2003 Chattopadhyay N, Wang Z, Ashman LK, Brady-Kalnay SM, Kreidberg JA, 'Alpha3 beta1 integrin-CD151, a component of the cadherin-catenin complex, regulates PTPu expression and cell-cell adhesion', The Journal of Cell Biology, 163 1351-1362 (2003) [C1]
DOI 10.1083/jcb.200306067
Citations Scopus - 96Web of Science - 94
2003 Ferrao PT, Gonda T, Ashman LK, 'Constitutively active mutant D816VKit induces megakayocyte and mast cell differentiation of early haemopoietic cells from murine foetal liver', Leukemia Research, 27 547-555 (2003) [C1]
DOI 10.1016/S0145-2126(02)00272-2
Citations Scopus - 21Web of Science - 23
2003 To LB, Bashford J, Durrant S, Macmillan J, Schwarer AP, Prince HM, et al., 'Successful mobilisation of peripheral blood stem cell after addition of ancestim (stem cell factor) in patients who had failed a prior mobilisation with filgrastim (granulocyte colony stimulating factor) alone or with chemotherapy plus filgrastim', Bone Marrow Transplantation, 31 371-378 (2003) [C1]
DOI 10.1038/sj.bmt.1703860
Citations Web of Science - 33
2002 Ashman LK, 'CD151', Journal of Biological Regulators and Homeostatic Agents, 16 223-226 (2002) [C1]
Citations Scopus - 11Web of Science - 10
2002 Frost MJ, Ferrao PT, Hughes T, Ashman LK, 'Juxtamembrane Mutant V560GKit Is more Sensitive to Imatinib (ST1571) Compared with Wild-Type c-Kit Whereas the Kinase Domain Mutant D816VKit is Resistant', Molecular Cancer Therapeutics, 1 1115-1124 (2002) [C1]
Citations Scopus - 195Web of Science - 179
2002 Fletcher J, Fletcher C, Rubin B, Ashman LK, Corless C, Heinrich M, 'KIT Gene Mutations in Gastrointestinal Stromal Tumors - More Complex than Previously Recognized?', American Journal of Pathology, 161, No 2 737-738 (2002) [C3]
Citations Web of Science - 15
2001 Geary SM, Cambaren AC, Fitter S, Ashman LK, 'Differential tissue expression of epitopes of the tetraspanin CD151 recognised by monoclonal antibodies', Tissue Antigens, 58 142-153 (2001) [C1]
Citations Web of Science - 28
2001 Chian RJ, Young S, Danilkovitch-Miagkova A, Ronnstrand L, Leonard E, Ferrao P, et al., 'Phosphatidylinositol 3 kinase contributes to the transformation of hematopoietic cells by the D816V c-Kit mutant', BLOOD, 98 1365-1373 (2001)
DOI 10.1182/blood.V98.5.1365
Citations Web of Science - 89
2001 Chian R, Young SM, Danilkovitch-Miagkova A, Ronnstrand L, Leonard E, Ferrao P, et al., 'PI3-kinase mediates transformation of hematopoietic cells by the V816 c-Kit mutant', Blood, 98 1365-1373 (2001) [C1]
2001 Berditchevski F, Gilbert E, Griffiths MR, Fitter S, Ashman L, Jenner SJ, 'Analysis of the CD151 center dot alpha(3)beta(1) integrin and CD151 center dot tetraspanin interactions by mutagenesis.', JOURNAL OF BIOLOGICAL CHEMISTRY, 276 41165-41174 (2001)
DOI 10.1074/jbc.M104041200
Citations Web of Science - 73
2001 Berditchevksi F, Gilbert E, Griffiths MR, Fitter S, Ashman L, Jenner SJ, 'Analysis of the CD151-a3b1 integrin and CD151-tetraspanin interactions by mutagenesis 41165-41174 (2001) [C1]
2001 Ferrao P, Sincock P, Cole S, Ashman L, 'Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukaemia', LEUKEMIA RESEARCH, 25 395-405 (2001)
DOI 10.1016/S0145-2126(00)00156-9
Citations Web of Science - 37
2001 Ferrao P, Sincock P, Cole S, Ashman L, 'Intracellular P-gp contributes to functional drug efflux and resistance in acute myeloid leukaemia (vol 25, pg 395, 2001)', LEUKEMIA RESEARCH, 25 827-827 (2001)
DOI 10.1016/S0145-2126(01)00120-5
Citations Web of Science - 2
2001 Ferrao PT, Frost MJ, Coles CJ, Domaschenz RM, Hughes TP, Ashman LK, 'Activated mutant D816VKit confers resistance to chemotherapeutic drugs, irradiation and STI 571.', CLINICAL CANCER RESEARCH, 7 3742S-3742S (2001)
2000 Linnekin D, Young S, Danilkovitch-Miagkova A, Ronnstrand L, Leonard E, Ferrao P, et al., 'PI3 kinase mediates transformation of hematopoietic cells by THF V816 c-Kit mutant.', BLOOD, 96 498A-498A (2000)
2000 Chian R, Young S, Danilkovitch-Miagkova A, Ronnstrand L, Leonard E, Ferrao P, et al., 'P13 kinase mediates transformation of hematopoietic cells by the V816 c-Kit mutant', EXPERIMENTAL HEMATOLOGY, 28 1491-1491 (2000)
DOI 10.1016/S0301-472X(00)00562-2
Citations Web of Science - 5
2000 Ashman LK, Ferrao P, Cole SR, Cambareri AC, 'Effects of mutant c-Kit in early myeloid cells (vol 34, pg 451, 1997)', LEUKEMIA & LYMPHOMA, 37 233-243 (2000)
DOI 10.3109/10428190009057652
Citations Web of Science - 16
1999 Heberlein C, Friel J, Laker C, von Laer D, Bergholz U, Bogel M, et al., 'Downregulation of c-kit (stem cell factor receptor) in transformed hematopoietic precursor cells by stroma cells', BLOOD, 93 554-563 (1999)
Citations Web of Science - 5
1999 Brach MA, Buhring HJ, Gruss HJ, Ashman LK, Ludwig WD, Mertelsmann RH, Herrmann F, 'Functional expression of c-kit by acute myelogenous leukemia blasts is enhanced by tumor necrosis factor-alpha through posttranscriptional mRNA stabilization by a labile protein (Retraction of vol 80, pg 1224, 1992)', BLOOD, 93 3573-3573 (1999)
1999 Brach MA, Herrmann F, Kufe DW, 'Activation of the AP-1 transcription factor by arabinofuranosylcytosine in myeloid leukemia cells (Retraction of vol 79, pg 728, 1992)', BLOOD, 93 3573-3573 (1999)
1999 Gibson MA, Leavesley DI, Ashman LK, 'Microfibril-associated glycoprotein-2 specifically interacts with a range of bovine and human cell types via alpha(v)beta(3) integrin', JOURNAL OF BIOLOGICAL CHEMISTRY, 274 13060-13065 (1999)
DOI 10.1074/jbc.274.19.13060
Citations Web of Science - 47
1999 Sincock PM, Fitter S, Parton RG, Berndt MC, Gamble JR, Ashman LK, 'PETA-3/CD151, a member of the transmembrane 4 superfamily, is localised to the plasma membrane and endocytic system of endothelial cells, associates with multiple integrins and modulates cell function', JOURNAL OF CELL SCIENCE, 112 833-844 (1999)
Citations Web of Science - 126
1999 Fitter S, Sincock PM, Jolliffe CN, Ashman LK, 'Transmembrane 4 superfamily protein CD151 (PETA-3) associates with beta(1) and alpha(IIb)beta(3) integrins in haemopoietic cell lines and modulates cell-cell adhesion', BIOCHEMICAL JOURNAL, 338 61-70 (1999)
DOI 10.1042/0264-6021:3380061
Citations Web of Science - 85
1999 Linnekin D, Ashman L, Ferrao P, Chian R, Keller J, 'Signaling mechanisms of an oncogenic form of c-Kit in hematopoietic cells', EXPERIMENTAL HEMATOLOGY, 27 56-56 (1999)
1999 Caruana G, Cambareri AC, Ashman LK, 'Isoforms of c-KIT differ in activation of signalling pathways and transformation of NIH3T3 fibroblasts', ONCOGENE, 18 5573-5581 (1999)
DOI 10.1038/sj.onc.1202939
Citations Web of Science - 66
1999 Ashman LK, Ferrao P, Cole SR, Cambareri AC, 'Effects of mutant c-Kit in early myeloid cells', LEUKEMIA & LYMPHOMA, 34 451-461 (1999)
Citations Web of Science - 22
1999 Ashman LK, 'The biology of stem cell factor and its receptor C-kit', INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 31 1037-1051 (1999)
DOI 10.1016/S1357-2725(99)00076-X
Citations Web of Science - 333
1998 Okayama Y, Kobayashi H, Ashman LK, Dobashi K, Nakazawa T, Holgate ST, et al., 'Human lung mast cells are enriched in the capacity to produce granulocyte-macrophage colony-stimulating factor in response to IgE-dependent stimulation', EUROPEAN JOURNAL OF IMMUNOLOGY, 28 708-715 (1998)
DOI 10.1002/(SICI)1521-4141(199802)28:02<708::AID-IMMU708>3.0.CO;2-A
Citations Web of Science - 27
1998 Yanez-Mo M, Alfranca A, Cabanas C, Marazuela M, Tejedor R, Ursa MA, et al., 'Regulation of endothelial cell motility by complexes of tetraspan molecules CD81/TAPA-1 and CD151/PETA-3 with alpha 3 beta 1 integrin localized at endothelial lateral junctions', JOURNAL OF CELL BIOLOGY, 141 791-804 (1998)
DOI 10.1083/jcb.141.3.791
Citations Web of Science - 192
1998 Fitter S, Seldin MF, Ashman LK, 'Characterisation of the mouse homologue of CD151 (PETA-3/SFA-1); genomic structure, chromosomal localisation and identification of 2 novel splice forms', BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION, 1398 75-85 (1998)
DOI 10.1016/S0167-4781(98)00034-7
Citations Web of Science - 12
1998 Afonja O, Amorosi E, Ashman L, Takeshita K, 'Multilineage involvement and erythropoietin-"independent" erythroid progenitor cells in a patient with systemic mastocytosis', ANNALS OF HEMATOLOGY, 77 183-186 (1998)
DOI 10.1007/s002770050439
Citations Web of Science - 21
1998 Caruana G, Cambareri AC, Gonda TJ, Ashman LK, 'Transformation of NIH3T3 fibroblasts by the c-Kit receptor tyrosine kinase: effect of receptor density and ligand-requirement', ONCOGENE, 16 179-190 (1998)
DOI 10.1038/sj.onc.1201494
Citations Web of Science - 23
1997 Ferrao P, Gonda TJ, Ashman LK, 'Expression of constitutively activated human c-Kit in myb transformed early myeloid cells leads to factor independence, histiocytic differentiation, and tumorigenicity', BLOOD, 90 4539-4552 (1997)
Citations Web of Science - 35
1997 Sincock PM, Mayrhofer G, Ashman LK, 'Localization of the transmembrane 4 superfamily (TM4SF) member PETA-3 (CD151) in normal human tissues: Comparison with CD9, CD63, and alpha 5 beta 1 integrin', JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 45 515-525 (1997)
Citations Web of Science - 133
1997 Atkins GJ, Qiao M, Coombe DR, Gowans EJ, Ashman LK, 'Hepatitis B virus binding to leucocyte plasma membranes utilizes a different region of the preS1 domain to the hepatocyte receptor binding site and does not require receptors for opsonins', IMMUNOLOGY AND CELL BIOLOGY, 75 259-266 (1997)
DOI 10.1038/icb.1997.40
Citations Web of Science - 1
1997 Sincock PM, Ashman LK, 'Expression of c-Kit and functional drug efflux are correlated in de novo acute myeloid leukaemia', LEUKEMIA, 11 1850-1857 (1997)
DOI 10.1038/sj.leu.2400823
Citations Web of Science - 19
1997 Zannettino ACW, Aylett GW, Leavesley DI, Pietsch T, Chang DG, Simmons PJ, Ashman LK, 'Specificity and functional effects of antibodies to human stem cell factor', GROWTH FACTORS, 14 67-79 (1997)
DOI 10.3109/08977199709021511
Citations Web of Science - 2
1996 Kurosawa K, Miyazawa K, Gotoh A, Katagiri T, Nishimaki J, Ashman LK, Toyama K, 'Immobilized anti-KIT monoclonal antibody induces ligand-independent dimerization and activation of steel factor receptor: Biologic similarity with membrane-bound form of steel factor rather than its soluble form', BLOOD, 87 2235-2243 (1996)
Citations Web of Science - 25
1996 Geary SM, Ashman LK, 'HL-60 myeloid leukaemia cells acquire immunostimulatory capability upon treatment with retinoic acid: Analysis of the responding population and mechanism of cytotoxic lymphocyte activation', IMMUNOLOGY, 88 428-440 (1996)
DOI 10.1046/j.1365-2567.1996.d01-668.x
Citations Web of Science - 8
1996 Zannettino ACW, Rayner JR, Ashman LK, Gonda TJ, Simmons PJ, 'A powerful new technique for isolating genes encoding cell surface antigens using retroviral expression cloning', JOURNAL OF IMMUNOLOGY, 156 611-620 (1996)
Citations Web of Science - 41
1996 Shimizu YJ, Ashman LK, Du ZM, Schwartz LB, 'Internalization of Kit together with stem cell factor on human fetal liver-derived mast cells - New protein and RNA synthesis is required for reappearance of Kit', JOURNAL OF IMMUNOLOGY, 156 3443-3449 (1996)
Citations Web of Science - 36
1996 Baghestanian M, Agis H, Bevec D, Bankl HC, Hofbauer R, Kress HG, et al., 'Stem cell factor-induced downregulation of c-kit in human lung mast cells and HMC-1 mast cells', EXPERIMENTAL HEMATOLOGY, 24 1377-1386 (1996)
Citations Web of Science - 32
1996 Cole SR, Aylett GW, Casey G, Harvey NL, Cambareri AC, Ashman LK, 'Increased expression of c-Kit or its ligand Steel Factor is not a common feature of adult acute myeloid leukaemia', LEUKEMIA, 10 288-296 (1996)
Citations Web of Science - 32
1996 Gattei V, Aldinucci D, Quinn JMW, Degan M, Cozzi M, Perin V, et al., 'Human osteoclasts and preosteoclast cells (FLG 29.1) express functional c-kit receptors and interact with osteoblast and stromal cells via membrane-bound stem cell factor', CELL GROWTH & DIFFERENTIATION, 7 753-763 (1996)
Citations Web of Science - 35
1995 KEES UR, ASHMAN LK, 'SYNERGISTIC ACTION OF INTERLEUKIN-2 AND STEEL FACTOR (SLF) ON A HUMAN T-LYMPHOBLASTOID CELL-LINE', LEUKEMIA, 9 1046-1050 (1995)
Citations Web of Science - 10
1995 SHIMIZU Y, ASHMAN L, SCHWARTZ LB, 'REGULATION OF KIT DURING STEM-CELL FACTOR (SCF)-DEPENDENT DEVELOPMENT OF FETAL LIVER-DERIVED HUMAN MAST-CELLS', FASEB JOURNAL, 9 A200-A200 (1995)
1995 FERRAO P, MACMILLAN EM, ASHMAN LK, GONDA TJ, 'ENFORCED EXPRESSION OF FULL-LENGTH C-MYB LEADS TO DENSITY-DEPENDENT TRANSFORMATION OF MURINE HEMATOPOIETIC-CELLS', ONCOGENE, 11 1631-1638 (1995)
Citations Web of Science - 43
1995 SHIMIZU Y, IRANI AMA, BROWN EJ, ASHMAN LK, SCHWARTZ LB, 'HUMAN MAST-CELLS DERIVED FROM FETAL LIVER-CELLS CULTURED WITH STEM-CELL FACTOR EXPRESS A FUNCTIONAL CD51/CD61 (ALPHA-V-BETA-3) INTEGRIN', BLOOD, 86 930-939 (1995)
Citations Web of Science - 32
1995 FITTER S, TETAZ TJ, BERNDT MC, ASHMAN LK, 'MOLECULAR-CLONING OF CDNA-ENCODING A NOVEL PLATELET-ENDOTHELIAL CELL TETRA-SPAN ANTIGEN, PETA-3', BLOOD, 86 1348-1355 (1995)
Citations Web of Science - 79
1995 Gattei V, Aldinucci D, Quinn JMW, Degan M, Cozzi M, Perin V, et al., 'Human primary osteoclasts and preosteoclast cells (FLG 29.1) express functional c-kit receptors and interact with osteoblast and stromal cells via membrane-bound stem cell factor (mb-SCF)', BLOOD, 86 79-79 (1995)
1995 Ashman LK, Sincock PM, Cole SR, 'Functional drug efflux P-glycoprotein and c-Kit expression in acute myeloid leukemia.', BLOOD, 86 2048-2048 (1995)
1995 Zannettino ACW, Buhring HJ, Niutta S, Ashman LK, Kanz L, Simmons PJ, 'Identification and functional cloning of MGC-24, a mucin-like molecule expressed by haemopoietic progenitors and bone marrow stromal cells: A negative regulator of haemopoiesis', BLOOD, 86 2350-2350 (1995)
Citations Web of Science - 1
1995 ROBERTS JJ, RODGERS SE, DRURY J, ASHMAN LK, LLOYD JV, 'PLATELET ACTIVATION-INDUCED BY A MURINE MONOCLONAL-ANTIBODY DIRECTED AGAINST A NOVEL TETRA-SPAN ANTIGEN', BRITISH JOURNAL OF HAEMATOLOGY, 89 853-860 (1995) [C1]
Citations Scopus - 35Web of Science - 36
1995 IRANI AA, NILSSON G, ASHMAN LK, SCHWARTZ LB, 'DEXAMETHASONE INHIBITS THE DEVELOPMENT OF MAST-CELLS FROM DISPERSED HUMAN FETAL LIVER-CELLS CULTURED IN THE PRESENCE OF RECOMBINANT HUMAN STEM-CELL FACTOR', IMMUNOLOGY, 84 72-78 (1995)
Citations Web of Science - 23
1995 ASHMAN LK, AYLETT GW, CAMBARERI AC, LEVESQUE JP, SIMMONS PJ, 'STEEL FACTOR AND ITS RECEPTOR C-KIT MEDIATE CELL-CELL INTERACTIONS', JOURNAL OF INVESTIGATIVE DERMATOLOGY, 105 2-2 (1995)
1994 NILSSON G, MIETTINEN U, ISHIZAKA T, ASHMAN LK, IRANI AM, SCHWARTZ LB, 'INTERLEUKIN-4 INHIBITS THE EXPRESSION OF KIT AND TRYPTASE DURING STEM-CELL FACTOR-DEPENDENT DEVELOPMENT OF HUMAN MAST-CELLS FROM FETAL LIVER-CELLS', BLOOD, 84 1519-1527 (1994)
Citations Web of Science - 57
1994 TO LB, HAYLOCK DN, DOWSE T, SIMMONS PJ, TRIMBOLI S, ASHMAN LK, JUTTNER CA, 'A COMPARATIVE-STUDY OF THE PHENOTYPE AND PROLIFERATIVE CAPACITY OF PERIPHERAL-BLOOD (PB) CD34(+) CELLS MOBILIZED BY 4 DIFFERENT PROTOCOLS AND THOSE OF STEADY-PHASE PB AND BONE-MARROW CD34(+) CELLS', BLOOD, 84 2930-2939 (1994)
Citations Web of Science - 202
1994 KUROSAWA K, MIYAZAWA K, GOTOH A, NISHIMAKI J, ASHMAN LK, TOYAMA K, 'IMMOBILIZED YB5.B8 MONOCLONAL-ANTIBODY INDUCES LIGAND-INDEPENDENT DIMERIZATION AND ACTIVATION OF C-KIT ENCODED PROTEIN - BIOLOGICAL SIMILARITY WITH MEMBRANE-BOUND FORM OF STEEL FACTOR RATHER THAN ITS SOLUBLE FORM', BLOOD, 84 A123-A123 (1994)
1994 ASHMAN LK, FITTER S, TETAZ T, BERNDT MC, 'MOLECULAR-CLONING OF CDNA-ENCODING A NOVEL PLATELET ENDOTHELIAL-CELL TETRASPAN ANTIGEN', BLOOD, 84 A243-A243 (1994)
1994 ASHMAN LK, BUHRING HJ, AYLETT GW, BROUDY VC, MULLER C, 'EPITOPE MAPPING AND FUNCTIONAL-STUDIES WITH 3 MONOCLONAL-ANTIBODIES TO THE C-KIT RECEPTOR TYROSINE KINASE, YB5.B8, 17F11, AND SR-1', JOURNAL OF CELLULAR PHYSIOLOGY, 158 545-554 (1994)
DOI 10.1002/jcp.1041580321
Citations Web of Science - 26
1994 OKAYAMA Y, HUNT TC, KASSEL O, ASHMAN LK, CHURCH MK, 'ASSESSMENT OF THE ANTI-C-KIT MONOCLONAL-ANTIBODY YB5.B8 IN AFFINITY MAGNETIC ENRICHMENT OF HUMAN LUNG MAST-CELLS', JOURNAL OF IMMUNOLOGICAL METHODS, 169 153-161 (1994)
DOI 10.1016/0022-1759(94)90259-3
Citations Web of Science - 57
1994 GRABBE J, WELKER P, MOLLER A, DIPPEL E, ASHMAN LK, CZARNETZKI BM, 'COMPARATIVE CYTOKINE RELEASE FROM HUMAN MONOCYTES, MONOCYTE-DERIVED IMMATURE MAST-CELLS, AND A HUMAN MAST-CELL LINE (HMC-1)', JOURNAL OF INVESTIGATIVE DERMATOLOGY, 103 504-508 (1994)
DOI 10.1111/1523-1747.ep12395649
Citations Web of Science - 55
1994 SIMMONS PJ, AYLETT GW, NIUTTA S, TO LB, JUTTNER CA, ASHMAN LK, 'C-KIT IS EXPRESSED BY PRIMITIVE HUMAN HEMATOPOIETIC-CELLS THAT GIVE RISE TO COLONY-FORMING CELLS IN STROMA-DEPENDENT CYTOKINE-SUPPLEMENTED CULTURE', EXPERIMENTAL HEMATOLOGY, 22 157-165 (1994)
Citations Web of Science - 72
1994 OKAYAMA Y, HUNT TC, KASSEL O, ASHMAN L, CHURCH MK, 'ASSESSMENT OF THE ANTI-C-KIT MONOCLONAL-ANTIBODY - YB5,B8 IN MAGNETIC AFFINITY ENRICHMENT OF HUMAN MAST-CELLS PREPARATIONS', CLINICAL AND EXPERIMENTAL ALLERGY, 24 179-179 (1994)
1994 SIMMONS PJ, LEAVESLEY DI, LEVESQUE JP, SWART BW, HAYLOCK DN, TO LB, et al., 'THE MOBILIZATION OF PRIMITIVE HEMATOPOIETIC PROGENITORS INTO THE PERIPHERAL-BLOOD', STEM CELLS, 12 187-202 (1994)
Citations Web of Science - 42
1993 TO LB, HAYLOCK DN, DOWSE T, SIMMONS PJ, ASHMAN LK, JUTTNER CA, 'PHENOTYPE AND PROLIFERATIVE CAPACITY OF PERIPHERAL-BLOOD CD34+ CELLS MOBILIZED BY 4 DIFFERENT PROTOCOLS', BLOOD, 82 A493-A493 (1993)
Citations Web of Science - 1
1993 LLOYD JV, ROBERTS JJ, RODGERS SE, ASHMAN LK, 'PLATELET ACTIVATION BY THE MURINE MONOCLONAL ANTIBODY-14A2.H1', BLOOD, 82 A609-A609 (1993)
1993 NILSSON G, FORSBERG K, BODGER MP, ASHMAN LK, ZSEBO KM, ISHIZAKA T, et al., 'PHENOTYPIC CHARACTERIZATION OF STEM-CELL FACTOR-DEPENDENT HUMAN FETAL LIVER-DERIVED MAST-CELLS', IMMUNOLOGY, 79 325-330 (1993)
Citations Web of Science - 50
1993 TOHDA S, YANG GS, ASHMAN LK, MCCULLOCH EA, MINDEN MD, 'RELATIONSHIP BETWEEN C-KIT EXPRESSION AND PROLIFERATION IN ACUTE MYELOBLASTIC-LEUKEMIA CELL-LINES', JOURNAL OF CELLULAR PHYSIOLOGY, 154 410-418 (1993)
DOI 10.1002/jcp.1041540225
Citations Web of Science - 29
1993 FURITSU T, TSUJIMURA T, TONO T, IKEDA H, KITAYAMA H, KOSHIMIZU U, et al., 'IDENTIFICATION OF MUTATIONS IN THE CODING SEQUENCE OF THE PROTOONCOGENE C-KIT IN A HUMAN MAST-CELL LEUKEMIA-CELL LINE CAUSING LIGAND-INDEPENDENT ACTIVATION OF C-KIT PRODUCT', JOURNAL OF CLINICAL INVESTIGATION, 92 1736-1744 (1993)
DOI 10.1172/JCI116761
Citations Web of Science - 604
1993 MATOS ME, SCHNIER GS, BEECHER MS, ASHMAN LK, WILLIAMS DE, CALIGIURI MA, 'EXPRESSION OF A FUNCTIONAL C-KIT RECEPTOR ON A SUBSET OF NATURAL-KILLER-CELLS', JOURNAL OF EXPERIMENTAL MEDICINE, 178 1079-1084 (1993)
DOI 10.1084/jem.178.3.1079
Citations Web of Science - 115
1993 ASANO Y, BRACH MA, AHLERS A, DEVOS S, BUTTERFIELD JH, ASHMAN LK, et al., 'PHORBOL ESTER 12-O-TETRADECANOYLPHORBOL-13-ACETATE DOWN-REGULATES EXPRESSION OF THE C-KIT PROTOONCOGENE PRODUCT', JOURNAL OF IMMUNOLOGY, 151 2345-2354 (1993)
Citations Web of Science - 14
1993 MAZE R, HORIE M, HENDRIE P, VADHANRAJ S, TRICOT G, GORDON M, et al., 'DIFFERENTIAL RESPONSES OF MYELOID PROGENITOR CELLS FROM PATIENTS WITH MYELOID-LEUKEMIA AND MYELODYSPLASIA TO THE COSTIMULATING EFFECTS OF STEEL FACTOR IN-VITRO', EXPERIMENTAL HEMATOLOGY, 21 545-551 (1993)
Citations Web of Science - 15
1993 CARUANA G, ASHMAN LK, FUJITA J, GONDA TJ, 'RESPONSES OF THE MURINE MYELOID CELL-LINE FDC-P1 TO SOLUBLE AND MEMBRANE-BOUND FORMS OF STEEL FACTOR (SLF)', EXPERIMENTAL HEMATOLOGY, 21 761-768 (1993)
Citations Web of Science - 37
1993 ATKINS GJ, GOWANS EJ, ASHMAN LK, 'HEPATITIS-B VIRUS RECEPTORS ON HEMATOPOIETIC-CELLS', JOURNAL OF LEUKOCYTE BIOLOGY, 46-46 (1993)
1993 GEARY SM, ASHMAN LK, 'IMMUNOSTIMULATORY NATURE OF A HUMAN LEUKEMIC-CELL LINE, HL-60, AFTER TREATMENT WITH RETINOIC ACID', JOURNAL OF LEUKOCYTE BIOLOGY, 89-89 (1993)
1993 ZANNETTINO ACW, RAYNER J, ASHMAN LK, GONDA TJ, SIMMONS PJ, 'USE OF A RETROVIRAL CDNA EXPRESSION LIBRARY TO CLONE GENES ENCODING NOVEL HUMAN STROMAL CELL ANTIGENS', JOURNAL OF LEUKOCYTE BIOLOGY, 103-103 (1993)
1993 FITTER S, BERNDT MC, ZANNETTINO ACW, ASHMAN LK, 'MOLECULAR-CLONING OF CDNA-ENCODING A NOVEL HUMAN PLATELET MEGAKARYOCYTE SURFACE-ANTIGEN', JOURNAL OF LEUKOCYTE BIOLOGY, 103-103 (1993)
1993 TOHDA S, ASHMAN LK, MINDEN MD, 'THE ROLE OF STROMA CELLS ON THE PROLIFERATION AND C-KIT EXPRESSION OF ACUTE MYELOBLASTIC-LEUKEMIA CELLS', INTERNATIONAL JOURNAL OF ONCOLOGY, 3 1141-1147 (1993)
1992 CICUTTINI FM, MARTIN M, SALVARIS E, ASHMAN L, BEGLEY CG, NOVOTNY J, et al., 'SUPPORT OF HUMAN CORD BLOOD PROGENITOR CELLS ON HUMAN STROMAL CELL-LINES TRANSFORMED BY SV(40) LARGE T-ANTIGEN UNDER THE INFLUENCE OF AN INDUCIBLE (METALLOTHIONEIN) PROMOTER', BLOOD, 80 102-112 (1992)
Citations Web of Science - 37
1992 BRACH MA, BUHRING HJ, GRUSS HJ, ASHMAN LK, LUDWIG WD, MERTELSMANN RH, HERRMANN F, 'FUNCTIONAL EXPRESSION OF C-KIT BY ACUTE MYELOGENOUS LEUKEMIA BLASTS IS ENHANCED BY TUMOR-NECROSIS-FACTOR-ALPHA THROUGH POSTTRANSCRIPTIONAL MESSENGER-RNA STABILIZATION BY A LABILE PROTEIN (RETRACTED ARTICLE. SEE VOL 93, PG. 3573, 1999)', BLOOD, 80 1224-1230 (1992)
Citations Web of Science - 28
1992 IRANI AMA, NILSSON G, MIETTINEN U, CRAIG SS, ASHMAN LK, ISHIZAKA T, et al., 'RECOMBINANT HUMAN STEM-CELL FACTOR STIMULATES DIFFERENTIATION OF MAST-CELLS FROM DISPERSED HUMAN FETAL LIVER-CELLS', BLOOD, 80 3009-3021 (1992)
Citations Web of Science - 209
1992 JACOBSON MR, BENTLEY AM, CUMBERWORTH V, SCHWARTZ LB, IRANI AM, ASHMAN LK, et al., 'IMMUNOHISTOLOGY OF THE NASAL-MUCOSA IN SEASONAL ALLERGIC RHINITIS - INCREASES IN ACTIVATED EOSINOPHILS AND EPITHELIAL MAST-CELLS', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 89 216-216 (1992)
Citations Web of Science - 1
1992 HUNT TC, HEUSSER C, MUELLER R, BULLOCK G, OKAYAMA Y, ASHMAN LK, CHURCH MK, 'HUMAN LUNG MAST-CELLS PRODUCE INTERLEUKIN-4', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 89 245-245 (1992)
Citations Web of Science - 4
1992 MAZE R, HORIE M, HENDRIE PC, VADHANRAJ S, TRICOT G, ASHMAN LK, BROXMEYER HE, 'HETEROGENEOUS RESPONSIVENESS INVITRO OF MYELOID PROGENITOR CELLS FROM PATIENTS WITH MYELOID-LEUKEMIA TO THE CO-STIMULATING EFFECTS OF STEEL FACTOR', EXPERIMENTAL HEMATOLOGY, 20 761-761 (1992)
1992 SIMMONS PJ, NIUTTA S, ASHMAN LK, BERNDT MC, JUTTNER CA, 'PRIMITIVE HUMAN BONE-MARROW PROGENITORS EXPRESS L-SELECTIN AND PECAM-1(CD31)', EXPERIMENTAL HEMATOLOGY, 20 829-829 (1992)
Citations Web of Science - 2
1991 ASHMAN LK, AYLETT GW, CAMBARERI AC, COLE S, 'DIFFERENT EPITOPES OF THE CD31 ANTIGEN IDENTIFIED BY MONOCLONAL-ANTIBODIES - CELL TYPE-SPECIFIC PATTERNS OF EXPRESSION', TISSUE ANTIGENS, 38 199-207 (1991)
DOI 10.1111/j.1399-0039.1991.tb01898.x
Citations Web of Science - 26
1991 ASHMAN LK, AYLETT GW, 'EXPRESSION OF CD31-EPITOPES ON HUMAN-LYMPHOCYTES - CD31-MONOCLONAL ANTIBODIES DIFFERENTIATE BETWEEN NAIVE (CD45RA+) AND MEMORY (CD45RA-) CD4-POSITIVE T-CELLS', TISSUE ANTIGENS, 38 208-212 (1991)
DOI 10.1111/j.1399-0039.1991.tb01899.x
Citations Web of Science - 34
1991 LERNER NB, NOCKA KH, COLE S, QIU FH, STRIFE A, ASHMAN LK, BESMER P, 'MONOCLONAL ANTIBODY-YB5.B8 IDENTIFIES THE HUMAN C-KIT PROTEIN PRODUCT', BLOOD, 77 1876-1883 (1991)
Citations Web of Science - 166
1991 ASHMAN LK, CAMBARERI AC, TO LB, LEVINSKY RJ, JUTTNER CA, 'EXPRESSION OF THE YB5.B8 ANTIGEN (C-KIT PROTOONCOGENE PRODUCT) IN NORMAL HUMAN BONE-MARROW', BLOOD, 78 30-37 (1991)
Citations Web of Science - 180
1991 ASHMAN LK, AYLETT GW, MEHRABANI PA, BENDALL LJ, NIUTTA S, CAMBARERI AC, et al., 'THE MURINE MONOCLONAL-ANTIBODY, 14A2.H1, IDENTIFIES A NOVEL PLATELET SURFACE-ANTIGEN', BRITISH JOURNAL OF HAEMATOLOGY, 79 263-270 (1991)
DOI 10.1111/j.1365-2141.1991.tb04531.x
Citations Web of Science - 23
1991 SILLABER C, STROBL H, BEVEC D, ASHMAN LK, BUTTERFIELD JH, LECHNER K, et al., 'IL-4 REGULATES C-KIT PROTOONCOGENE PRODUCT EXPRESSION IN HUMAN MAST AND MYELOID PROGENITOR CELLS', JOURNAL OF IMMUNOLOGY, 147 4224-4228 (1991)
Citations Web of Science - 121
1991 MIYAZAWA K, HENDRIE PC, MANTEL C, WOOD K, ASHMAN LK, BROXMEYER HE, 'COMPARATIVE-ANALYSIS OF SIGNALING PATHWAYS BETWEEN MAST-CELL GROWTH-FACTOR (C-KIT LIGAND) AND GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR IN A HUMAN FACTOR-DEPENDENT MYELOID CELL-LINE INVOLVES PHOSPHORYLATION OF RAF-1, GTPASE-ACTIVATING PROTEIN AND MITOGEN-ACTIVATED PROTEIN-KINASE', EXPERIMENTAL HEMATOLOGY, 19 1110-1123 (1991)
Citations Web of Science - 134
1990 ASHMAN LK, CAMBARERI AC, EGLINTON JM, 'A MONOCLONAL-ANTIBODY THAT INHIBITS THE ACTION OF GM-CSF ON NORMAL BUT NOT LEUKEMIC PROGENITORS', LEUKEMIA RESEARCH, 14 637-644 (1990)
DOI 10.1016/0145-2126(90)90019-6
Citations Web of Science - 9
1989 VALENT P, ASHMAN LK, HINTERBERGER W, ECKERSBERGER F, MAJDIC O, LECHNER K, BETTELHEIM P, 'MAST-CELL TYPING - DEMONSTRATION OF A DISTINCT HEMATOPOIETIC-CELL TYPE AND EVIDENCE FOR IMMUNOPHENOTYPIC RELATIONSHIP TO MONONUCLEAR PHAGOCYTES', BLOOD, 73 1778-1785 (1989)
Citations Web of Science - 201
1989 COLE S, KRIEK GW, HOPE RM, ASHMAN LK, 'TRANSFECTION OF GENES FOR HUMAN CELL-SURFACE ANTIGENS IDENTIFIED BY MONOCLONAL-ANTIBODIES', IMMUNOLOGY AND CELL BIOLOGY, 67 377-384 (1989)
DOI 10.1038/icb.1989.54
Citations Web of Science - 5
1988 LYONS AB, COOPER SJ, COLE S, ASHMAN LK, 'HUMAN MYELOID DIFFERENTIATION ANTIGENS IDENTIFIED BY MONOCLONAL-ANTIBODIES TO THE MYELOMONOCYTIC LEUKEMIA-CELL LINE RC-2A', PATHOLOGY, 20 137-146 (1988)
Citations Web of Science - 16
1988 LYONS AB, ASHMAN LK, 'THE EFFECT OF RECOMBINANT CYTOKINES ON THE PROLIFERATIVE POTENTIAL AND PHENOTYPE OF CELLS OF THE HUMAN MYELOMONOCYTIC LEUKEMIA LINE, RC-2A', LEUKEMIA RESEARCH, 12 659-666 (1988)
DOI 10.1016/0145-2126(88)90100-2
Citations Web of Science - 3
1988 ASHMAN LK, ROBERTS MM, GADD SJ, COOPER SJ, JUTTNER CA, 'EXPRESSION OF A 150-KD CELL-SURFACE ANTIGEN IDENTIFIED BY MONOCLONAL-ANTIBODY YB5.B8 IS ASSOCIATED WITH POOR PROGNOSIS IN ACUTE NON-LYMPHOBLASTIC LEUKEMIA', LEUKEMIA RESEARCH, 12 923-928 (1988)
DOI 10.1016/0145-2126(88)90020-3
Citations Web of Science - 72
1988 CAMBARERI AC, ASHMAN LK, COLE S, LYONS AB, 'A MONOCLONAL-ANTIBODY TO A HUMAN MAST-CELL MYELOID LEUKEMIA-SPECIFIC ANTIGEN BINDS TO NORMAL HEMATOPOIETIC PROGENITOR CELLS AND INHIBITS COLONY FORMATION INVITRO', LEUKEMIA RESEARCH, 12 929-& (1988)
DOI 10.1016/0145-2126(88)90021-5
Citations Web of Science - 27
1987 VALENT P, STAIN C, ASHMAN LK, BRANTSCHEN S, STADLER BM, HINTERBERGER W, et al., 'THE PHENOTYPE OF HUMAN CONNECTIVE-TISSUE TYPE (CTMC) AND MUCOSAL MAST-CELLS (MMC)', BLUT, 55 360-360 (1987)
1987 WHITE DL, ASHMAN LK, DART GW, ZOLA H, TOOGOOD IRG, KIMBER RJ, 'THE EXPRESSION OF MATURE MYELOID CELL-DIFFERENTIATION MARKERS IN ACUTE-LEUKEMIA', PATHOLOGY, 19 137-142 (1987)
Citations Web of Science - 12
1987 ASHMAN L, ROBERTS M, GADD S, COOPER S, JUTTNER C, 'A SUBGROUP OF ANLL WITH POOR RESPONSE TO STANDARD CHEMOTHERAPY IDENTIFIED BY A MONOCLONAL-ANTIBODY', MEDICAL AND PEDIATRIC ONCOLOGY, 15 152-152 (1987)
1987 ASHMAN LK, WHITE D, ZOLA H, DART GW, 'EXPRESSION OF THE NON-T ALL-ASSOCIATED P24 ANTIGEN ON LEUKEMIC BLASTS FROM PATIENTS WITH ANLL', LEUKEMIA RESEARCH, 11 97-& (1987)
DOI 10.1016/0145-2126(87)90109-3
Citations Web of Science - 8
1987 LYONS AB, ASHMAN LK, 'STUDIES ON THE DIFFERENTIATION OF THE HUMAN MYELOMONOCYTIC CELL-LINE RC-2A IN RESPONSE TO LYMPHOCYTE-DERIVED FACTORS', LEUKEMIA RESEARCH, 11 797-& (1987)
DOI 10.1016/0145-2126(87)90064-6
Citations Web of Science - 3
1987 COLE S, ASHMAN LK, EY PL, 'BIOTINYLATION - AN ALTERNATIVE TO RADIOIODINATION FOR THE IDENTIFICATION OF CELL-SURFACE ANTIGENS IN IMMUNOPRECIPITATES', MOLECULAR IMMUNOLOGY, 24 699-705 (1987)
DOI 10.1016/0161-5890(87)90051-4
Citations Web of Science - 166
1987 ASHMAN LK, KRIEK GW, COOPER SJ, OKEEFE DE, 'REQUIREMENTS FOR THE STIMULATION OF ALLOGENEIC LYMPHOCYTES-T BY ACUTE NONLYMPHOBLASTIC LEUKEMIA-CELLS', CANCER IMMUNOLOGY IMMUNOTHERAPY, 25 250-256 (1987)
Citations Web of Science - 3
1987 ASHMAN LK, DREW PA, TOOGOOD IRG, JUTTNER CA, 'IMMUNOLOGICAL COMPETENCE OF PATIENTS IN REMISSION FROM ACUTE-LEUKEMIA - APPARENTLY NORMAL T-CELL FUNCTION BUT DEFECTIVE POKEWEED MITOGEN-DRIVEN IMMUNOGLOBULIN-SYNTHESIS', IMMUNOLOGY AND CELL BIOLOGY, 65 201-210 (1987)
DOI 10.1038/icb.1987.22
1987 MAYRHOFER G, GADD SJ, SPARGO LDJ, ASHMAN LK, 'SPECIFICITY OF A MOUSE MONOCLONAL-ANTIBODY RAISED AGAINST ACUTE MYELOID-LEUKEMIA CELLS FOR MAST-CELLS IN HUMAN MUCOSAL AND CONNECTIVE TISSUES', IMMUNOLOGY AND CELL BIOLOGY, 65 241-250 (1987)
DOI 10.1038/icb.1987.27
Citations Web of Science - 92
1987 ASHMAN LK, 'THE IMMUNOGENICITY OF TUMOR-CELLS', IMMUNOLOGY AND CELL BIOLOGY, 65 271-277 (1987)
DOI 10.1038/icb.1987.31
Citations Web of Science - 6
1986 WHITE DL, ASHMAN LK, DART GW, ZOLA H, KIMBER RJ, 'THE SELECTION OF A PANEL OF LOCALLY PRODUCED MONOCLONAL-ANTIBODIES FOR THE CLASSIFICATION OF ACUTE LEUKEMIAS', AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 16 124-124 (1986)
1986 EY PL, ASHMAN LK, 'THE USE OF ALKALINE PHOSPHATASE-CONJUGATED ANTIIMMUNOGLOBULIN WITH IMMUNOBLOTS FOR DETERMINING THE SPECIFICITY OF MONOCLONAL-ANTIBODIES TO PROTEIN MIXTURES', METHODS IN ENZYMOLOGY, 121 497-509 (1986)
Citations Web of Science - 107
1986 ASHMAN LK, OKEEFE DE, JUTTNER CA, TOOGOOD IRG, RICE MS, 'AUTOLOGOUS RESPONSES TO HUMAN-LEUKEMIC CELLS IN MIXED LEUKOCYTE-CULTURE', CANCER IMMUNOLOGY IMMUNOTHERAPY, 22 95-99 (1986)
Citations Web of Science - 7
1985 GADD SJ, BROGAN MP, ASHMAN LK, 'SPECIFICITY OF THE PASSIVE ANTIBODY-INDUCED SUPPRESSION OF THE HUMORAL IMMUNE-RESPONSE OF MICE TO SURFACE-ANTIGENS ON HUMAN-CELLS', IMMUNOLOGY, 54 223-231 (1985)
Citations Web of Science - 5
1985 GESCHE AH, ASHMAN LK, 'VARIATIONS IN ANTIGEN EXPRESSION DURING THE CELL-CYCLE OF A HUMAN B-LYMPHOBLASTOID CELL-LINE', LEUKEMIA RESEARCH, 9 147-& (1985)
DOI 10.1016/0145-2126(85)90028-1
Citations Web of Science - 6
1985 ASHMAN LK, GESCHE AH, 'SURFACE-ANTIGEN EXPRESSION BY A HUMAN B-LYMPHOBLASTOID CELL-LINE TREATED WITH DIFFERENTIATION INDUCERS, DIMETHYSULFOXIDE AND TETRADECANOYLPHORBOL ACETATE', LEUKEMIA RESEARCH, 9 157-& (1985)
DOI 10.1016/0145-2126(85)90029-3
Citations Web of Science - 7
1985 GADD SJ, ASHMAN LK, 'A MURINE MONOCLONAL-ANTIBODY SPECIFIC FOR A CELL-SURFACE ANTIGEN EXPRESSED BY A SUBGROUP OF HUMAN MYELOID LEUKEMIAS', LEUKEMIA RESEARCH, 9 1329-1336 (1985)
DOI 10.1016/0145-2126(85)90119-5
Citations Web of Science - 70
1985 LYONS AB, ASHMAN LK, 'THE ROSE-BENGAL ASSAY FOR MONOCLONAL-ANTIBODIES TO CELL-SURFACE ANTIGENS - COMPARISONS WITH COMMON HYBRIDOMA SCREENING METHODS', JOURNAL OF IMMUNOASSAY, 6 325-345 (1985)
DOI 10.1080/01971528508063037
Citations Web of Science - 5
1984 ASHMAN LK, 'PROLIFERATIVE RESPONSE OF NORMAL AND ACTIVATED HUMAN-LYMPHOCYTES TO TETRADECANOYL PHORBOL ACETATE', CELLULAR IMMUNOLOGY, 87 613-625 (1984)
DOI 10.1016/0008-8749(84)90029-7
Citations Web of Science - 18
1983 GADD SJ, ASHMAN LK, 'BINDING OF MOUSE MONOCLONAL-ANTIBODIES TO HUMAN-LEUKEMIC CELLS VIA THE FC RECEPTOR - A POSSIBLE SOURCE OF FALSE POSITIVE REACTIONS IN SPECIFICITY SCREENING', CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 54 811-818 (1983)
Citations Web of Science - 39
1983 ASHMAN LK, 'IMMUNE-RESPONSES TO HUMAN-LEUKEMIC CELLS-INVITRO', MEDICAL AND PEDIATRIC ONCOLOGY, 11 197-197 (1983)
1983 ASHMAN LK, 'STIMULATORY ABILITY OF HUMAN-LEUKEMIC CELLS IN THE ALLOGENEIC MIXED LEUKOCYTE REACTION', AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 61 477-488 (1983)
DOI 10.1038/icb.1983.45
Citations Web of Science - 4
1982 OKEEFE D, ASHMAN L, 'PEANUT AGGLUTININ - A MARKER FOR NORMAL AND LEUKEMIC-CELLS OF THE MONOCYTE LINEAGE', CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 48 329-338 (1982)
Citations Web of Science - 29
1982 OKEEFE D, ASHMAN L, 'VARIATION IN ACCESSORY CELL REQUIREMENTS IN HUMAN MIXED LYMPHOCYTE-RESPONSE TO LEUKEMIC-CELL LINES', IMMUNOLOGY, 47 633-641 (1982)
Citations Web of Science - 17
1982 OCONNOR CG, ASHMAN LK, 'APPLICATION OF THE NITROCELLULOSE TRANSFER TECHNIQUE AND ALKALINE-PHOSPHATASE CONJUGATED ANTI-IMMUNOGLOBULIN FOR DETERMINATION OF THE SPECIFICITY OF MONOCLONAL-ANTIBODIES TO PROTEIN MIXTURES', JOURNAL OF IMMUNOLOGICAL METHODS, 54 267-271 (1982)
DOI 10.1016/0022-1759(82)90068-0
Citations Web of Science - 109
1982 ASHMAN LK, MURRAY AW, COOK MG, KOTLARSKI I, '2-STAGE SKIN CARCINOGENESIS IN SENSITIVE AND RESISTANT MOUSE STRAINS', CARCINOGENESIS, 3 99-102 (1982)
DOI 10.1093/carcin/3.1.99
Citations Web of Science - 25
1980 VINGELIS V, ASHMAN LK, KOTLARSKI I, 'FACTORS AFFECTING THE ABILITY OF VARIOUS STRAINS OF ENTEROBACTERIACEAE TO INDUCE TUMOR RESISTANCE IN MICE', AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 58 123-131 (1980)
DOI 10.1038/icb.1980.12
Citations Web of Science - 4
1980 ASHMAN LK, GOH DHB, KOTLARSKI I, 'INVOLVEMENT OF DONOR LYMPHORETICULAR CELLS IN THE REJECTION OF B-16 MELANOMA BY ALLOGENEIC MICE', AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 58 159-166 (1980)
DOI 10.1038/icb.1980.16
Citations Web of Science - 11
1980 DEYOUNG NJ, ASHMAN LK, LUDBROOK J, MARSHALL VR, 'COMPARISON OF 3 BLOOD-TESTS FOR CANCER', SURGERY GYNECOLOGY & OBSTETRICS, 150 12-16 (1980)
Citations Web of Science - 6
1979 DEYOUNG NJ, ASHMAN LK, LUDBROOK J, MARSHALL VR, 'CANCER DISCRIMINATORY ABILITY OF THE CARCINOEMBRYONIC ANTIGEN-ASSAY, PHOSPHOHEXOSE ISOMERASE ACTIVITY AND ERYTHROCYTE SEDIMENTATION-RATE', AUSTRALIAN AND NEW ZEALAND JOURNAL OF SURGERY, 49 145-146 (1979)
1979 ASHMAN LK, KOTLARSKI I, 'INHIBITION OF THE GROWTH OF LEWIS LUNG-CARCINOMA IN SYNGENEIC MICE BY SALMONELLA ANTIGENS', AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 57 637-639 (1979)
DOI 10.1038/icb.1979.67
Citations Web of Science - 1
1979 ASHMAN LK, COOK MG, KOTLARSKI I, 'PROTECTIVE EFFECT OF ORAL SALMONELLA-ENTERITIDIS 11RX INFECTION AGAINST COLON-TUMOR INDUCTION BY 1,2-DIMETHYLHYDRAZINE IN MICE', CANCER RESEARCH, 39 2768-2771 (1979)
Citations Web of Science - 5
1978 DEYOUNG NJ, ASHMAN LK, 'PHYSICOCHEMICAL AND IMMUNOCHEMICAL PROPERTIES OF CARCINOEMBRYONIC ANTIGEN (CEA) FROM DIFFERENT TUMOR SOURCES', AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 56 321-331 (1978)
DOI 10.1038/icb.1978.34
Citations Web of Science - 14
1978 ASHMAN LK, KOTLARSKI I, 'EFFECT OF SALMONELLA-ENTERITIDIS 11RX INFECTION ON 2-STAGE SKIN CARCINOGENESIS IN MICE', AUSTRALIAN JOURNAL OF EXPERIMENTAL BIOLOGY AND MEDICAL SCIENCE, 56 695-701 (1978)
DOI 10.1038/icb.1978.76
Citations Web of Science - 11
1977 ASHMAN LK, LUDBROOK J, MARSHALL VR, 'COMPARISON OF WHOLE PLASMA AND PERCHLORIC ACID-EXTRACTED PLASMA ASSAYS FOR CARCINOEMBRYONIC ANTIGEN', CLINICA CHIMICA ACTA, 74 77-84 (1977)
DOI 10.1016/0009-8981(77)90390-4
Citations Web of Science - 9
1977 ASHMAN LK, DEYOUNG NJ, 'IMMUNOADSORBENT PURIFICATION OF CARCINOEMBRYONIC ANTIGEN', IMMUNOCHEMISTRY, 14 329-336 (1977)
DOI 10.1016/0019-2791(77)90232-4
Citations Web of Science - 7
1975 ASHMAN LK, DEYOUNG NJ, GEARY D, LUDBROOK J, 'CARCINOEMBRYONIC ANTIGEN LEVELS IN PLASMA OF CANCER-PATIENTS AND OF CANCER-FREE HOSPITAL INPATIENTS', AUSTRALIAN AND NEW ZEALAND JOURNAL OF SURGERY, 45 109-109 (1975)
1975 ASHMAN LK, KEECH DB, 'KINETIC APPROACH TO DEFINING ROLE OF CHEMICALLY MODIFIABLE RESIDUES AT ACTIVE-SITES OF ENZYMES', AUSTRALIAN JOURNAL OF BIOLOGICAL SCIENCES, 28 379-387 (1975)
Citations Web of Science - 2
1975 ASHMAN LK, KEECH DB, 'SHEEP KIDNEY PYRUVATE-CARBOXYLASE - STUDIES ON COUPLING OF ADENOSINE-TRIPHOSPHATE HYDROLYSIS AND CO2 FIXATION', JOURNAL OF BIOLOGICAL CHEMISTRY, 250 14-21 (1975)
Citations Web of Science - 52
1975 ASHMAN LK, DEYOUNG NJ, 'IMMUNOADSORBENT PURIFICATION OF A GLYCOPROTEIN FROM HUMAN TUMOR TISSUE', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 8 40-40 (1975)
1975 ASHMAN LK, 'PURIFICATION OF CARCINOEMBRYONIC ANTIGEN BY AFFINITY CHROMATOGRAPHY USING IMMOBILIZED ANTIBODIES', CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2 82-82 (1975)
1975 ASHMAN LK, LUDBROOK J, MARSHALL VR, 'PROBABILISTIC APPLICATION OF PLASMA CARCINOEMBRYONIC ANTIGEN ASSAY IN CANCER-PATIENTS', BRITISH MEDICAL JOURNAL, 2 721-724 (1975)
Citations Web of Science - 12
1974 ASHMAN LK, KEECH DB, 'ANALOG STUDIES OF PYRUVATE-CARBOXYLASE REACTION-MECHANISM', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 7 18-18 (1974)
1973 ASHMAN LK, WALLACE JC, KEECH DB, 'DESENSITIZATION OF PYRUVATE CARBOXYLASE AGAINST ACETYL COA STIMULATION BY CHEMICAL MODIFICATION', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 51 924-931 (1973)
DOI 10.1016/0006-291X(73)90015-6
Citations Web of Science - 23
1973 ASHMAN LK, KEECH DB, 'DESENSITIZATION OF ALLOSTERIC ACTIVATION OF PYRUVATE CARBOXYLASE', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 6 12-12 (1973)
1972 ASHMAN LK, ATWELL JL, 'AMP DEAMINASE FROM RABBIT SKELETAL-MUSCLE - EFFECT OF MONOVALENT CATIONS ON CATALYTIC ACTIVITY AND MOLECULAR-WEIGHT', BIOCHIMICA ET BIOPHYSICA ACTA, 258 618-& (1972)
DOI 10.1016/0005-2744(72)90253-7
Citations Web of Science - 33
1972 ASHMAN LK, WALLACE JC, KEECH DB, NIELSEN J, 'SHEEP KIDNEY PYRUVATE CARBOXYLASE - STUDIES ON ITS ACTIVATION BY ACETYL COENZYME-A AND CHARACTERISTICS OF ITS ACETYL COENZYME-A INDEPENDENT REACTION', JOURNAL OF BIOLOGICAL CHEMISTRY, 247 5818-& (1972)
Citations Web of Science - 60
Show 183 more journal articles

Conference (26 outputs)

Year Citation Altmetrics Link
2014 Bond DR, Passfield C, Cairns M, Ashman LK, Weidenhofer J, 'Posttranscriptional regulation of tetraspanins CD151 & CD9 in breast & prostate cancers', CANCER RESEARCH, San Diego, CA (2014) [E3]
DOI 10.1158/1538-7445.AM2014-4364
Co-authors Murray Cairns, Judith Weidenhofer
2013 Weidenhofer J, Bond D, Copeland B, Ashman L, 'Tetraspanin protein turnover rates vary in prostate cancer cell lines', BJU INTERNATIONAL (2013) [E3]
Co-authors Judith Weidenhofer
2013 Bond D, Cairns M, Ashman L, Weidenhofer J, 'Post-transcriptional regulation of CD151 & CD9 by miRNAs in prostate cancer', BJU INTERNATIONAL (2013) [E3]
Co-authors Judith Weidenhofer, Murray Cairns
2013 Copeland B, Ashman L, 'Tetraspanins as potential biomarkers in prostate cancer', BJU INTERNATIONAL (2013) [E3]
2012 Bond DR, Cairns MJ, Ashman LK, Weidenhofer JC, 'Investigating micro-RNA regulation of tetraspanins CD151 and CD9 in prostate cancer', Febs Journal, Seville, Spain (2012) [E3]
Co-authors Judith Weidenhofer, Murray Cairns
2011 Moheimani F, Ashman LK, Wright MD, Jackson DE, 'Novel molecular association of ADP purinergic receptor, P2Y12 with tetraspanin superfamily member, CD151 in human platelets', JOURNAL OF THROMBOSIS AND HAEMOSTASIS (2011)
Co-authors Fatemeh Moheimani
2011 Vilain R, Braye SG, Ashman LK, Scott R, 'BRAF and NRAS mutational status are prognostically important in thick and locally advanced cutaneous melanoma', Pigment Cell & Melanoma Research, Tampa, FL (2011) [E3]
DOI 10.1111/j.1755-148X.2011.00909.x
Co-authors Rodney Scott
2011 Mashkani B, Ashman LK, Griffith R, 'Implication of molecular docking in the study of structure-activity relationship of receptor tyrosine kinases inhibitors', Clinical Biochemistry, Mashhad, Iran (2011) [E3]
2011 Naudin C, Weidenhofer JC, Scott R, Ashman LK, Roselli SM, 'Induction of mindin expression is associated with glomerular basement membrane damage in Cd151(-/-) mice', Nephrology, Adelaide, SA (2011) [E3]
Co-authors Judith Weidenhofer, Rodney Scott
2010 Vilain RE, Braye SG, Ashman LK, Scott R, 'Characterisation of KIT mutated melanomas: A step in the development of patient-tailored treatement for melanoma', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
Co-authors Rodney Scott
2010 Verrills NM, Roberts KG, Smith AM, McDougall FK, Carpenter HC, Neviani P, et al., 'Targeting the tumour suppressor, PP2A, as a novel therapy for acute myeloid leukaemia', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
Co-authors Alistair Sim, Nikki Verrills
2010 Copeland BT, Vilain RE, Ashman LK, 'Biomarkers and regulatory proteins in prostate cancer', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
2010 Vilain RE, Ashton KA, Bowden NA, Braye SG, Ashman LK, Scott RJ, 'Clinicopathological and gene expression profiling of advanced melanoma harbouring KIT and common kinase mutations', Melanoma 2010 Congress. Oral and Poster Abstracts, Sydney, NSW (2010) [E3]
Co-authors Nikola Bowden, Katie Ashton
2008 Baleato RM, Guthrie PL, Gubler M-C, Ashman LK, Roselli S, 'CD151-DEFICIENT MICE DEVELOP A STRAIN-DEPENDENT KIDNEY DISEASE DUE TO ALTERATIONS OF THE GLOMERULAR BASEMENT MEMBRANE', NEPHROLOGY (2008) [E3]
2008 Mashkani B, Kim K-T, Griffith R, Ashman LK, 'Different behaviour of FDC-P1 cells expressing different FLT3 activating mutations', HMRI Conference on Translational Cancer Research Abstracts, Newcastle, NSW (2008) [E3]
2007 Roberts KG, Ashman LK, Sim AT, Verrills NM, 'Regulation of protein phosphatase 2A (PP2A) B subunits by Bcr/Abl: Potential targets for chronic myeloid leukemia', AACR Meeting Abstracts Online (Abstracts of the 98th AACR Annual Meeting), Los Angeles (2007) [E3]
Co-authors Nikki Verrills, Alistair Sim
2007 Roberts KG, Ashman LK, Sim ATR, Verrills NM, 'Altered expression of PP2A regulatory subunits in chronic myelogenous leukemia: Identifying targets for improved therapies', BLOOD, Atlanta, GA (2007)
Co-authors Nikki Verrills
2005 Foster R, Byrnes E, Ferrao P, Meldrum C, Ross G, Upjohn E, et al., 'A polymorphism in the transmembrane domain of c-KIT associated with pediatric mastocytosis', JOURNAL OF INVESTIGATIVE DERMATOLOGY, Perth, AUSTRALIA (2005)
Co-authors Rodney Scott
2005 Cowin AJ, Geary SM, Adams D, Wright MD, Ashman LK, 'Epidermal wound healing is defective in mice lacking tetraspanin CD151', JOURNAL OF INVESTIGATIVE DERMATOLOGY, Perth, AUSTRALIA (2005)
2004 Griffith R, Foster RC, Brown MN, Ashman LK, 'Design of inhibitors of the KIT receptor tyrosine kinase', EuroQSAR 2004 Proceedings, Instanbul, Turkey (2004) [E1]
2004 Foster RC, Griffith R, Ferrao PT, Ashman LK, 'Molecular Modelling of c-Kit Kinase Domains', MM2004: 9th Molecular Modelling Workshop, Sydney, Australia (2004) [E3]
2004 Geary SM, Cowin A, Fitter S, Wright MD, Ashman LK, 'Defective in vitro epidermal wound healing in mice lacking the tetraspanin CD151', JOURNAL OF INVESTIGATIVE DERMATOLOGY, Nice, FRANCE (2004)
2003 Ashman LK, Ferrao PT, Foster RC, Griffith R, 'Analysis of the Structure of the Kinase Domain of the Stem Cell Factor Receptor Tyrosin Kinase (c-Kit) - Constitutive Activation by a D816V Mutation and Inhibition by STI571', Fifth AFMC International Medicinal Chemistry Symposium AIMECS 03, Kyoto, Japan (2003) [E3]
1997 Okayama Y, Kobayashi H, Ashman LK, Holgate ST, Church MK, Mori M, 'Activation of eosinophils with cytokines produced by lung mast cells', INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY, TOKYO, JAPAN (1997)
Citations Web of Science - 17
1995 Laver JH, Abboud MR, Kawashima I, Leary AG, Ashman LK, Ogawa M, 'Characterization of c-kit expression by primitive hematopoietic progenitors in umbilical cord blood', EXPERIMENTAL HEMATOLOGY, DUSSELDORF, GERMANY (1995)
Citations Web of Science - 30
1994 KANAKURA Y, FURITSU T, TSUJIMURA T, BUTTERFIELD JH, ASHMAN LK, IKEDA H, et al., 'ACTIVATING MUTATIONS OF THE C-KIT PROTOONCOGENE IN A HUMAN MAST-CELL LEUKEMIA-CELL LINE', LEUKEMIA, MONTREAL, CANADA (1994)
Citations Web of Science - 36
Show 23 more conferences
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Grants and Funding

Summary

Number of grants 67
Total funding $12,981,258

Click on a grant title below to expand the full details for that specific grant.


20131 grants / $24,596

20124 grants / $494,694

High-Resolution Isoelectric Phosphoprotein Signalling System for Signalling Research, Biomarker Validation and Drug Development – Equipment Grant$143,394

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Rick Thorne, Professor Xu Dong Zhang, Professor Hubert Hondermarck, Conjoint Professor Stephen Ackland, Doctor Lisa Lincz, Doctor Jennette Sakoff, Emeritus Professor Leonie Ashman
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200555
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Microscopic illumination system for advanced fluorescent protein technology$34,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Rick Thorne, Professor Xu Dong Zhang, Conjoint Associate Professor Murray Cairns, Doctor Nikki Verrills, Doctor Charles De Bock, Doctor Jude Weidenhofer, Doctor Severine Roselli, Doctor Kathryn Skelding, Emeritus Professor Leonie Ashman, Professor Hubert Hondermarck
Scheme Equipment Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100983
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Does Ubiquitination control the altered expression of tetraspanin proteins in Breast Cancer?$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jude Weidenhofer, Emeritus Professor Leonie Ashman, Professor Hubert Hondermarck
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200169
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20114 grants / $2,649,144

Hunter Translational Cancer Research Unit$1,693,333

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Conjoint Professor Stephen Ackland, Emeritus Professor Leonie Ashman, Professor John Forbes, Laureate Professor Robert Sanson-Fisher, Conjoint Associate Professor Anthony Proietto, Professor Rodney Scott
Scheme Translational Cancer Research Unit
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100545
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Priority Research Centre for Cancer$555,811

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Stephen Ackland, Professor Xu Dong Zhang, Professor John Forbes, Emeritus Professor Leonie Ashman, Doctor Nikola Bowden, Professor Gordon Burns, Conjoint Professor Jim Denham, Professor Hubert Hondermarck, Doctor Lisa Lincz, Doctor Jennette Sakoff, Associate Professor Peter Stanwell, Doctor Rick Thorne, Doctor Nikki Verrills
Scheme Priority Research Centre
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1101013
Type Of Funding Internal
Category INTE
UON Y

Identifying the mechanisms underlying altered expression and mode of action of tetraspanins CD151 and CD9 in metastasis: progression to targeted treatment for prostate cancer$375,000

Funding body: Prostate Cancer Foundation of Australia

Funding body Prostate Cancer Foundation of Australia
Project Team Emeritus Professor Leonie Ashman, Doctor Jude Weidenhofer
Scheme Project Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1000863
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Investigation of the function of CD151 in the glomerular filtration barrier and identification of genetic modifiers of glomerular diseases$25,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Severine Roselli, Doctor Jude Weidenhofer, Emeritus Professor Leonie Ashman
Scheme Near Miss Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1001053
Type Of Funding Internal
Category INTE
UON Y

20104 grants / $1,103,071

HMRI MRSP Infrastructure Grant (10-11) - CANCER$504,071

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Emeritus Professor Leonie Ashman, Conjoint Professor Stephen Ackland
Scheme NSW MRSP Infrastructure Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G1100269
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Laser microdissection microscopy system for cell and development biology$350,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Laureate Professor John Aitken, Associate Professor Brett Nixon, Doctor Shaun Roman, Professor Alan Brichta, Doctor Rick Thorne, Doctor Doug Smith, Associate Professor David McCurdy, Conjoint Professor Ray Rose, Professor Christopher Grof, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Doctor Brett Graham, Associate Professor Paul Tooney, Professor Roger Smith, Laureate Professor Paul Foster, Professor Trevor Day, Professor Robert Callister
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0190369
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

ABI 7500 Real Time PCR System $34,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Rick Thorne, Doctor Nikki Verrills, Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Doctor Doug Smith, Professor Gordon Burns, Emeritus Professor Leonie Ashman, Conjoint Professor Keith Jones, Doctor Charles De Bock, Doctor Chris Dayas, Doctor Brett Graham, Doctor Martin Horan, Doctor Rebecca Lim, Doctor Severine Roselli, Doctor Larisa Bobrovskaya, Doctor Kathryn Skelding, Doctor Frederick Walker, Doctor Jude Weidenhofer, Associate Professor Philip Bolton, Professor Alan Brichta, Professor Robert Callister, Professor Trevor Day, Associate Professor Phillip Dickson, Professor Manohar Garg, Doctor Phil Jobling, Associate Professor Derek Laver, Associate Professor Eugene Nalivaiko, Emeritus Professor John Rostas
Scheme Equipment Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000055
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20099 grants / $1,669,011

Tetraspanin proteins in prostate cancer progression and prognosis$341,000

Funding body: Cancer Council NSW

Funding body Cancer Council NSW
Project Team Emeritus Professor Leonie Ashman, Doctor Nikki Verrills, Conjoint Professor Jim Denham
Scheme Research Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0188877
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

MRSP Infrastructure (09-10) Cancer$283,916

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Emeritus Professor Leonie Ashman, Conjoint Professor Stephen Ackland
Scheme NSW MRSP Infrastructure Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0900172
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Confocal Laser Scanning Microscopy for Live Cell Imaging$275,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Conjoint Professor Keith Jones, Professor Eileen McLaughlin, Laureate Professor John Aitken, Conjoint Professor Ray Rose, Emeritus Professor John Patrick, Conjoint Professor Christina Offler, Associate Professor David McCurdy, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Professor Dirk Van Helden, Doctor Nikki Verrills, Associate Professor Brett Nixon, Doctor Shaun Roman, Associate Professor Yong-Ling Ruan, Doctor Rick Thorne, Professor Mike Calford
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189038
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

IVIS Lumina II fluorescence and bioluminescence imager for in vivo analysis of tumour growth and metastasis in mouse models$153,200

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Emeritus Professor Leonie Ashman
Scheme Research Equipment Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0189634
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Study of c-KIT mutations in familial gastrointestinal stromal tumours and malignant melanoma$44,720

Funding body: Pfizer Australia

Funding body Pfizer Australia
Project Team Mr Ricardo Vilain, Professor Rodney Scott, Emeritus Professor Leonie Ashman
Scheme Cancer Research Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189919
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Identification of genetic modifiers of kidney disease$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Severine Roselli, Emeritus Professor Leonie Ashman, Professor Rodney Scott
Scheme Project Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189793
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

3rd European Conference on Tetraspanins, Paris, 10-11 September 2009$1,175

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Leonie Ashman
Scheme Travel Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0900245
Type Of Funding Internal
Category INTE
UON Y

20084 grants / $1,408,790

HMRI Cancer Research Program - MRSP Infrastructure$1,031,290

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Stephen Ackland, Emeritus Professor Leonie Ashman, Professor John Forbes, Conjoint Professor Jim Denham, Conjoint Professor Peter Hersey, Professor Gordon Burns, Professor Adam McCluskey, Doctor Nikki Verrills
Scheme NSW MRSP Infrastructure Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188622
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

PP2A: a novel target for leukaemia therapy$300,000

Funding body: Cancer Council NSW

Funding body Cancer Council NSW
Project Team Doctor Nikki Verrills, Emeritus Professor Leonie Ashman, Professor Alistair Sim, Associate Professor Danilo Perrotti, Assoc. Prof Timothy Hughes, Dr David Thomas
Scheme Research Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0187694
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Role of tetraspanin proteins in human breast and prostate cancer$75,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Emeritus Professor Leonie Ashman, Doctor Severine Roselli
Scheme Mary Minto Sawyer Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188187
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

FASEB Summer Research conference $2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Leonie Ashman
Scheme Travel Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0189020
Type Of Funding Internal
Category INTE
UON Y

20076 grants / $418,000

FACSAria - Fluorescence activated cell sorter$300,000

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Doctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
Scheme Research Infrastructure Grants
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187666
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

HMRI Contribution toward FACSAria - Fluorescence activated cell sorter$52,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
Scheme Equipment Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188207
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Activity of kinase inhibitors on mutant forms of c-KIT in GIST and AML$27,500

Funding body: Novartis Pharmaceuticals Australia Pty Limited

Funding body Novartis Pharmaceuticals Australia Pty Limited
Project Team Emeritus Professor Leonie Ashman
Scheme Project Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0188467
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Polymerase Chain Reaction (PCR) machine and Spectrophotometer$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Leonie Ashman, Professor Alistair Sim, Doctor Nikki Verrills
Scheme Equipment Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0188195
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Regulation of cancer cell behaviour by tetraspanin molecular complexes$16,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Judith Scott, Emeritus Professor Leonie Ashman
Scheme Project Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187242
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Beatson International Cancer Conference Molecular Cancer Thereapies: new challenges and horizons, Caledonian University, Glasgow, UK, 17/6/2007 - 20/6/2007$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Leonie Ashman
Scheme Travel Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0187736
Type Of Funding Internal
Category INTE
UON Y

20064 grants / $1,418,962

2006 Research Fellowship$776,824

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Leonie Ashman
Scheme Research Fellowships
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0185093
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Structural studies of the binding of clinically relevant small-molecule injibitors to wildtype and mutant receptor tyrosine kinases$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Associate Professor Renate Griffith, Emeritus Professor Leonie Ashman
Scheme Pilot Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186710
Type Of Funding Internal
Category INTE
UON Y

BioRad Mini-PROTEAN3 Electrophoresis system$995

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Emeritus Professor Leonie Ashman, Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Professor Judith Scott, Professor Alistair Sim, Doctor Nikki Verrills
Scheme Equipment Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0187280
Type Of Funding Not Known
Category UNKN
UON Y

20059 grants / $1,362,590

Role of the tetraspanin CD151 in epithelial biology and cancer$447,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Leonie Ashman
Scheme Project Grant
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0183903
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

CD151 and functional overlap in tetraspanins$219,303

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Emeritus Professor Leonie Ashman, Dr Mark Wright
Scheme Discovery Projects
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0184421
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Protein kinase inhibitors for the treatment of acute myeloid leukaemia$217,500

Funding body: Anthony Rothe Memorial Trust

Funding body Anthony Rothe Memorial Trust
Project Team Emeritus Professor Leonie Ashman
Scheme Research Grant
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0184574
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Mechanisms of drug resistance in acute myeloid leukaemia$156,200

Funding body: Leukaemia Foundation of NSW

Funding body Leukaemia Foundation of NSW
Project Team Emeritus Professor Leonie Ashman
Scheme Research Grant
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0184615
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

2005 RIBG allocation$89,711

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Leonie Ashman
Scheme Research Infrastructure Block Grant (RIBG)
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0185800
Type Of Funding Internal
Category INTE
UON Y

How the cell surface protein, CD151 promotes invasive behaviour in breast cancer$15,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Emeritus Professor Leonie Ashman
Scheme Mary Minto Sawyer Grant
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0185658
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Oolemmal receptors - the role of the tetraspanin CD151 in sperm-egg fusion$7,537

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Eileen McLaughlin, Emeritus Professor Leonie Ashman
Scheme Project Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0184625
Type Of Funding Internal
Category INTE
UON Y

International Tetraspanins mini-symposium, June 30-July 1 2005, Federation of American Societies for Experimental Biology Summer Research Conference 16-21 July 2005$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Leonie Ashman
Scheme Travel Grant
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0185496
Type Of Funding Internal
Category INTE
UON Y

20045 grants / $233,136

Biacore3000-Expansion of Proteomics Facility$187,341

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Alistair Sim, Laureate Professor John Aitken, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Emeritus Professor Leonie Ashman, Professor Roger Smith, Professor Gordon Burns, Professor Adam McCluskey, Associate Professor Paul Tooney, Dr Fraser Ross, Conjoint Professor Ray Rose
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183030
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

New drugs targeting protein kinases$17,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Emeritus Professor Leonie Ashman, Professor Adam McCluskey
Scheme Research Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183751
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Characterisation of a novel recepto-mediated signal transduction pathway in human spermatozoa.$14,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Brett Nixon, Emeritus Professor Leonie Ashman
Scheme Project Grant
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183444
Type Of Funding Internal
Category INTE
UON Y

Is CD151 a co-receptor for human papilloma virus$12,395

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Leonie Ashman
Scheme Project Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0183418
Type Of Funding Internal
Category INTE
UON Y

FASEB Summer Research Conference: Advances in Tetraspanin Research, 19-24 June 2004, USA$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Leonie Ashman
Scheme Travel Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo G0184098
Type Of Funding Internal
Category INTE
UON Y

20033 grants / $34,900

Detection of mutations in c-kit in paediatric mastocytosis patient samples and structural analysis of the interaction between the D816VKit mutant and inhibitor$17,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Emeritus Professor Leonie Ashman, Dr Petranel Ferrao
Scheme Research Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0182632
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Molecular basis of cellular localisation of a cell membrane protein, CD151.$15,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Leonie Ashman
Scheme Project Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0182464
Type Of Funding Internal
Category INTE
UON Y

Beatson Conference: Cell signalling and Cancer, Glasgow, Scotland 6-9 July, 2003$2,400

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Leonie Ashman
Scheme Travel Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0183163
Type Of Funding Internal
Category INTE
UON Y

20029 grants / $1,776,206

Proteomic and Genomic Analysis Facility.$473,332

Funding body: Wellcome Trust

Funding body Wellcome Trust
Project Team Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Professor Rodney Scott, Emeritus Professor Leonie Ashman
Scheme Major Equipment Award
Role Investigator
Funding Start 2002
Funding Finish 2002
GNo G0181527
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

c-Kit signalling and cellular responses in haemopoietic cells$470,250

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Leonie Ashman
Scheme Research Fellowships
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0181693
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

c-Kit signalling and cellular responses in haemopoietic cells$377,024

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Leonie Ashman
Scheme Project Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0181692
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Use of retroviral libraries to characterise mechanisms of drug resistance in leukaemia$240,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Dr Petranel Ferrao, Emeritus Professor Leonie Ashman, Dr A Zannettino, Dr T Hughes
Scheme Project Grant
Role Investigator
Funding Start 2002
Funding Finish 2002
GNo G0181690
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Molecular determinants of subcellular localisation and function of the transmembrane 4 superfamily protein, PETA-3$107,512

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Leonie Ashman
Scheme Project Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0181691
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Role of PETA-3/CD151 in epithelial cancer invasion and metastasis.$70,008

Funding body: Cancer Council NSW

Funding body Cancer Council NSW
Project Team Emeritus Professor Leonie Ashman
Scheme Research Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0181686
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Peltier Thermal Cycler and associated equipment essential for establishing cDNA Retroviral Libraries$21,315

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Leonie Ashman, Dr Petranel Ferrao, Professor Gordon Burns, Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Dirk Van Helden, Dr Perry Hartfield
Scheme Equipment Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0181919
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

A tissue culture system for antibody production$14,265

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Leonie Ashman
Scheme New Staff Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0182574
Type Of Funding Internal
Category INTE
UON Y

FASEB Summer Research Conference: 2nd International Conf. on Tetraspanin Proteins Tuscan, AZ, USA, 15 - 20 June, 2002$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Leonie Ashman
Scheme Travel Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0181991
Type Of Funding Internal
Category INTE
UON Y

20015 grants / $388,158

c-KIT signalling and cellular responses in haemopoietic cells.$125,688

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team
Scheme Project
Role Lead
Funding Start 2001
Funding Finish 2001
GNo
Type Of Funding Not Known
Category UNKN
UON Y

Molecular determinants of subcellular localisation and function of the transmembrane 4 superfamily protein, PETA-3.$105,162

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team
Scheme Project
Role Lead
Funding Start 2001
Funding Finish 2001
GNo
Type Of Funding Not Known
Category UNKN
UON Y

c-KIT signalling and cellular responses in haemopoietic cells.$85,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team
Scheme Research Fellowships
Role Lead
Funding Start 2001
Funding Finish 2001
GNo
Type Of Funding Not Known
Category UNKN
UON Y

Role of PETA-3/CD151 in epithelial cancer invasion and metastasis.$60,308

Funding body: Cancer Council SA

Funding body Cancer Council SA
Project Team
Scheme Project
Role Lead
Funding Start 2001
Funding Finish 2001
GNo
Type Of Funding Not Known
Category UNKN
UON Y

Use of retroviral expression libraries to characterise mechanisms of drug resistance in leukaemia, $12,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team
Scheme Project
Role Investigator
Funding Start 2001
Funding Finish 2001
GNo
Type Of Funding Not Known
Category UNKN
UON Y
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Research Supervision

Number of supervisions

Completed13
Current1

Total current UON EFTSL

PhD0.1

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2011 PhD Post-Transcriptional Regulation of Tetraspanins CD151 and CD9 by Micro-RNA's in Prostate and Breast Cancers
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2015 PhD The Tetraspanin CD151's Role in the Kidney and Mapping of Genetic Modifiers of Glomerular Diseases
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Targeting PP2A Activation as a Novel Therapeutic Strategy for Receptor Tyrosine Kinase Driven Leukemia
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2013 PhD Tetraspanins as Biomarkers and Causative Proteins in Prostate Cancer
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2013 PhD Activating Kinase Mutations in Melanoma
Health, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2010 PhD Regulation of the Tumour Suppressor PP2A by Oncogenic Tyrosine Kinases
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2010 PhD Small Molecule Inhibitors for Type III Receptor Tyrosine Kinases
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2009 PhD c-KIT Polymorphisms in Pediatric Mastocytosis and Comparative Analysis of Wild Type c-KIT and the Asp816Val Mutant
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2007 Masters The Role of the Tetraspanin CD151 in Integrin/Growth Factor Receptor Complexes and Its Influence on Cancer Cell Behaviour
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2005 PhD Resistance to imatinib (STI 571) conferred by point mutations of Kit and BCR/ABL
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2004 PhD Subcellular Localisation and Internalisation of the Tetraspanin, CD151: Role of the Cytoplasmic Domains
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Sole Supervisor
2003 PhD Molecular and Cellular Studies of Isoforms of c-KIT
Biochemistry & Cell Biology, University of Adelaide
Principal Supervisor
2002 PhD Receptor tyrosine kinase c-KIT:signal transduction and biological response
Behavioural Science N.E.C., University of Adelaide
Sole Supervisor
2001 PhD Function of the soluble c-KIT extracellular domain
Biochemistry & Cell Biology, University of Adelaide
Sole Supervisor
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Emeritus Professor Leonie Ashman

Positions

Conjoint Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Emeritus Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Medical Biochemistry

Contact Details

Email leonie.ashman@newcastle.edu.au
Phone (08) 8376 9069
Mobile 0419840829
Fax -

Office

Room -
Building -
Location Adelaide SA

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