Staff Profile

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Career Summary

Biography

I completed my PhD investigating the molecular and cellular role of the amygdala in the aetiology of schizophrenia in 2006 at the University of Newcastle. Following a post-doctoral position at the Children's Oncology Unit at the Children's Hospital at Westmead investigating the role of TPD52 in breast development and breast cancer I returned to the University of Newcastle in 2008. Whilst this position was as a teaching focused academic, I initiated my own research direction under the supervision of Prof. Leonie Ashman which resulted in successful funding from the Prostate Cancer Foundation of Australia. Since 2011 I have lead my own research group investigating the regulation of the expression of tetraspanin proteins in breast and prostate cancers as well as the role of CD151 in glomerular disease.

Qualifications

  • Doctor of Philosophy, University of Newcastle, 06/06/2006

Research

Research keywords

  • Breast Cancer
  • Cancer Cell Biology
  • Gene & Protein expression regulation
  • Molecular Biology
  • Prostate Cancer
  • Tetraspanin proteins

Research expertise

My current research focus is on understanding the role of three tetraspanin proteins, CD151, CD9 and CD82 in breast and prostate cancers. These proteins show de-regulated expression in these cancers which is consistent with their proposed roles as tumour and metastasis enhancers (CD151) or suppressors (CD9 & CD82). Our aim is to identify the molecular mechanisms underlying their altered expression in cancer with a current focus on the role of miRNA and the ubiquitin system. We hope that by improving our understanding of how the expression of these proteins is controlled we can gain valuable insight into how they can be used as both prognostic indicators as well as novel therapeutic targets, particularly for metastatic disease.

In addition we are investigating the role that CD151 plays in the development and maintenance of the glomerular filtration barrier in the kidney. In particular we aim to identify biomarkers of glomerular disease through analysing mice in which CD151 expression has been lost and identifying the mechanisms involved in the development of and susceptibility to disease.

Fields of Research

CodeDescriptionPercentage
111200Oncology And Carcinogenesis50
060802Animal Cell And Molecular Biology25
060405Gene Expression (Incl. Microarray And Other Genome-Wide Approaches)25

Memberships

Committee/Associations (relevant to research).

  • Member - Australian Society of Biochemistry and Molecular Biology
  • Member - Australian Society of Medical Research

Appointments

NSW State Representative
Australian Society of Biochemistry and Molecular Biology (Australia)
01/03/2012

Invitations

Role and regulation of tetraspanins CD151 and CD9 in breast and prostate cancers
Institut Andre Lwoff, France (Invited Presenter)
2012

Administrative

Administrative expertise

I have been on the organising committe for several symposiums and research seminar series as well as other research related events. I am currently the NSW State representative for the Australian Society for Biochemistry and Molecular Biology (ASBMB). In a teaching capacity I have co-ordinated several courses at the University of Newcastle.

Teaching

Teaching keywords

  • Bioinformatics
  • Genetics
  • Molecular Biology
  • Protein biochemistry

Teaching expertise

My current teaching focus is on genetics, bioinformatics and cancer cell biology. I also have experience in DNA, transcription, translation, protein synthesis and function, protein analysis and molecular biology. I have experience teaching B.Biomed Sci, M. Pharmacy and B. Medicine.

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Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Chapter (1 outputs)

YearCitationAltmetricsLink
2009Weidenhofer J, Byrne JA, 'Isolation of nucleic acids from hard tissues', Handbook of Nucleic Acid Purification, CRC PressI Llc, United States 427-448 (2009)

Journal article (12 outputs)

YearCitationAltmetricsLink
2014Roselli S, Kahl RG, Copeland BT, Naylor MJ, Weidenhofer J, Muller WJ, Ashman LK, 'Deletion of Cd151 reduces mammary tumorigenesis in the MMTV/PyMT mouse model.', BMC Cancer, 14 509 (2014)
2014Mate K, Riveros C, Weidenhofer J, Goldie B, Scott J, Moscato P, et al., 'Strategies for Enhancing Communication between Students, Academics and Researchers participating in Large-Scale Undergraduate Research Projects', International Journal of Innovation in Science and Mathematics Education, [In Press] (2014)

Co-authors: Karen Mate, Liz Milward

2013Mate K, Sim A, Weidenhofer J, Milward L, Scott J, 'Investigation of the human disease osteogenesis imperfecta: A research-based introduction to concepts and skills in biomolecular analysis', Biochemistry & Molecular Biology Education, 41 103-109 (2013) [C1]
2012Tynan R, Weidenhofer JC, Hinwood M, Cairns MJ, Day TA, Walker FR, 'A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia', Brain Behavior and Immunity, 26 469-479 (2012) [C1]
2009Weidenhofer JC, Ashman LK, 'CD151 (CD151 molecule (Raph blood group))', Atlas of Genetics and Cytogenetics in Oncology and Haematology, - (2009) [C1]

Co-authors: Leonie Ashman

2009Weidenhofer JC, Scott R, Tooney PA, 'Investigation of the expression of genes affecting cytomatrix active zone function in the amygdala in schizophrenia: Effects of antipsychotic drugs', Journal of Psychiatric Research, 43 282-290 (2009) [C1]
2008Shehata M, Weidenhofer J, Thamotharampillai K, Byrne JA, 'Tumor protein D52 overexpression and gene amplification in cancer - from a mosaic of microarrays', Critical Reviews in Oncogenesis, 14 33-55 (2008) [C1]
2008Shehata M, Bieche I, Boutros R, Weidenhofer J, Fanayan S, Spalding L, et al., 'Nonredundant Functions for Tumor Protein D52-Like Proteins Support Specific Targeting of TPD52', Clinical Cancer Research, 14 5050-5060 (2008) [C1]
2006Weidenhofer JC, Yip JR, Zavitsanou K, Huang XF, Chahl LA, Tooney PA, 'Immunohistochemical localisation of the NK1 receptor in the human amygdala: Preliminary investigation in schizophrenia', Progress in Neuro-Psychopharmacology and Biological Psychiatry, 30 1313-1321 (2006) [C1]
2006Bowden NA, Weidenhofer JC, Scott R, Schall U, Todd J, Michie PT, Tooney PA, 'Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophrenia', Schizophrenia Research, 82 175-183 (2006) [C1]
2006Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Altered gene expression in the amygdala in schizophrenia: Up-regulation of genes located in the cytomatrix active zone', Molecular and Cellular Neuroscience, 31 243-250 (2006) [C1]
2006Weidenhofer J, Bowden NA, Scott RJ, Tooney PA, 'Dysfunction of genes regulating membrane exocytosis in schizophrenia', AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 40 A129-A129 (2006)
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Review (1 outputs)

YearCitationAltmetricsLink
2014Bond DB, Brzozowski J, Skelding KA, Roselli SR, Weidenhofer J, 'Use of tetraspanins CD151 and CD9 as biomarkers for breast cancer', Breast Cancer Management (2014)

Conference (11 outputs)

YearCitationAltmetricsLink
2013Weidenhofer J, Bond D, Copeland B, Ashman L, 'Tetraspanin protein turnover rates vary in prostate cancer cell lines', BJU INTERNATIONAL (2013) [E3]
2013Bond D, Cairns M, Ashman L, Weidenhofer J, 'Post-transcriptional regulation of CD151 & CD9 by miRNAs in prostate cancer', BJU INTERNATIONAL (2013) [E3]
2012Bond DR, Cairns MJ, Ashman LK, Weidenhofer JC, 'Investigating micro-RNA regulation of tetraspanins CD151 and CD9 in prostate cancer', Febs Journal, Seville, Spain (2012) [E3]
2011Naudin C, Weidenhofer JC, Scott R, Ashman LK, Roselli SM, 'Induction of mindin expression is associated with glomerular basement membrane damage in Cd151(-/-) mice', Nephrology, Adelaide, SA (2011) [E3]
2006Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Dysfunction of genes regulating membrane exocytosis in schizophrenia (Poster presentation)', Australian and New Zealand Journal of Psychiatry (Vol 40, noS2), Fremantle, Western Australia (2006) [E3]
2005Bowden NA, Weidenhofer JC, Scott R, Schall UA, Todd J, Michie PT, Tooney PA, 'Classification of schizophrenia using differential gene expression in peripheral blood lymphocytes', Human Genetics Society of Australasia, Newcastle (2005) [E3]
2004Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Gene Profiling in the Amygdala in Schizophrenia', American Journal of Medical Genetics, Ireland (2004) [E3]
2004Bowden NA, Weidenhofer JC, Scott R, Todd J, Case V, Schall UA, Tooney PA, 'Differental Gene Expression in Peripheral Blood Lymphocytes in Schizophrenia', Proceedings of the Australian Neuroscience Society, Melbourne (2004) [E3]
2004Bowden NA, Weidenhofer JC, Scott R, Todd J, Case V, Schall UA, Tooney PA, 'Altered Expression of Brain Related Genes in Lymphocytes in Schizophrenia', American Journal of Medical Genetics, Ireland (2004) [E3]
2004Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Altered Gene Expression Profiles in the Amygdala in Schizophrenia', Proceedings of the Australian Neuroscience Society, Melbourne (2004) [E3]
2004Bowden NA, Weidenhofer JC, Scott R, Todd J, Case V, Schall UA, Tooney PA, 'Distinct Gene Expression Profiles due to Age in Schizophrenia', Proceedings of the Australian Neuroscience Society, Melbourne (2004) [E3]
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Grants and Funding

Summary

Number of grants10
Total funding$1,124,146

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (1 grants)

Tetraspanin CD9; more than just an exosome marker - A novel biomarker to target for prostate cancer$300,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jude Weidenhofer, Doctor Kathryn Skelding, Doctor Matt Dun, Ms Belinda Goldie, Miss Danielle Bond
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$300,00020142016
GNo:G1400921

2013 (1 grants)

Ultra-Low Temperature Cryogenic Freezer$24,596
Funding Body: NHMRC (National Health & Medical Research Council)

2012 (4 grants)

The Hunter Cancer Biobank (HCB): Maximising community value through validation, annotation and distribution throughout NSW$292,300
Funding Body: Cancer Institute NSW

Project Team
Professor John Forbes, Conjoint Professor Stephen Ackland, Professor Rodney Scott, Conjoint Associate Professor Barbara Young, Professor Hubert Hondermarck, Emeritus Professor Leonie Ashman, Professor Xu Dong Zhang, Doctor Kelly Kiejda, Doctor Nikki Verrills, Doctor Jennette Sakoff, Ms Janine Lombard, Doctor Jude Weidenhofer, Doctor Pradeep Tanwar
SchemeRole
Infrastructure GrantsInvestigator
Total AmountFunding StartFunding Finish
$292,30020122014
GNo:G1200798

Microscopic illumination system for advanced fluorescent protein technology$34,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Rick Thorne, Professor Xu Dong Zhang, Conjoint Associate Professor Murray Cairns, Doctor Nikki Verrills, Doctor Charles De Bock, Doctor Jude Weidenhofer, Doctor Severine Roselli, Doctor Kathryn Skelding, Emeritus Professor Leonie Ashman, Professor Hubert Hondermarck
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$34,00020122012
GNo:G1100983

Does Ubiquitination control the altered expression of tetraspanin proteins in Breast Cancer?$25,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jude Weidenhofer, Emeritus Professor Leonie Ashman, Professor Hubert Hondermarck
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$25,00020122012
GNo:G1200169

PULSE - Education Prize$4,250
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Jude Weidenhofer
SchemeRole
PULSE Education PrizeChief Investigator
Total AmountFunding StartFunding Finish
$4,25020122012
GNo:G1200157

2011 (3 grants)

Identifying the mechanisms underlying altered expression and mode of action of tetraspanins CD151 and CD9 in metastasis: progression to targeted treatment for prostate cancer$375,000
Funding Body: Prostate Cancer Foundation of Australia

Project Team
Emeritus Professor Leonie Ashman, Doctor Jude Weidenhofer
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$375,00020112013
GNo:G1000863

Investigation of the function of CD151 in the glomerular filtration barrier and identification of genetic modifiers of glomerular diseases$25,000
Funding Body: University of Newcastle

Project Team
Doctor Severine Roselli, Doctor Jude Weidenhofer, Emeritus Professor Leonie Ashman
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$25,00020112011
GNo:G1001053

IMPLEN NanoPhotometer pearl$10,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Associate Professor Alan Brichta, Emeritus Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Professor Ulli Schall, Associate Professor Phillip Dickson, Doctor Frederick Walker, Doctor Rick Thorne, Doctor Chris Dayas, Doctor Nikki Verrills, Doctor Janet Holt, Doctor Severine Roselli, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Associate Professor Liz Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Mr Dan Johnstone, Ms Belinda Goldie, Ms Natalie Beveridge
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$10,00020112011
GNo:G1100030

2010 (1 grants)

ABI 7500 Real Time PCR System $34,000
Funding Body: NHMRC (National Health & Medical Research Council)

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Research Supervision

Number of current supervisions4
Total current UoN PhD EFTSL2.7

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20142018PhD (Medical Biochemistry)Principal SupervisorIdentification of Biomarkers and Novel Targets for Prostate Cancer from Exosomes
20142018PhD (Medical Biochemistry)Principal SupervisorDeveloping Synthetic Exosomes to Target and Deliver Anti-Cancer Agents to Prostate Cancer Cells
20112015PhD (Medical Biochemistry)Principal SupervisorThe Role of CD151 in Glomerular Diseases
20112015PhD (Medical Biochemistry)Principal SupervisorAn Investigation into Micro-RNA Regulation of Tetraspanins CD151 and CD9 in Breast and Prostate Cancer Progression

Past Supervision

YearProgramSupervisor TypeResearch Title
2013PhD (Medical Biochemistry)Co-SupervisorTetraspanins as Biomarkers and Causative Proteins in Prostate Cancer
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Dr Judith (Jude) Weidenhofer

Work Phone(02) 4921 8706
Fax(02) 43494538
Email
PositionAssociate Lecturer
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaMedical Biochemistry
Office
BE136,
Health Precinct,
Ourimbah
10 Chittaway Road
Ourimbah NSW 2258
Australia
URL:www.newcastle.edu.au/profile/judith-weidenhofer