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Laureate Professor John Aitken

Pro Vice-Chancellor

Office of the PVC Health and Medicine (Biological Sciences)

Giving birth to a better world

Laureate Professor John Aitken believes creating better methods of contraception and curing infertility are the two single most important issues facing the world - and this global authority on reproductive biology is leading the charge to achieve both. 

Professor Aitken, who arrived from the University of Edinburgh to take up a Chair in Biological Sciences at the University of Newcastle in 1999, is now a leader of a 50-strong research team studying fertility and contraception, which has attracted almost $50 million in funding.

"Each year the reproductive needs of some 120 million couples worldwide go unmet. I believe that finding more effective ways to control fertility is a critical global issue while, at an individual level, we should never forget the large number of couples seeking safe, effective solutions to their infertility," Professor Aitken, Director of the University of Newcastle's Priority Research Centre for Reproductive Science said.

"Essentially, all the world's problems are, one way or the other, connected to sustainable world population growth. If we get control of populations numbers, we can solve many of the difficulties facing mankind."

The 2012 New South Wales Scientist of the Year says the 'urgent need' to develop better contraception is demonstrated by the 46 million abortions performed worldwide every year due to people falling pregnant unintentionally. In Australia one in five pregnancies are aborted each year, equalling around 70,000 terminations, many in the under 19 or over 40 age groups.

"I regard abortion not as a moral failure but a contraception failure. We just don't have the right methods to empower women to control their own fertility," he said.

"If you think about human contraception it hasn't actually moved on since the contraceptive pill was introduced in 1960 and that was based on the biochemistry of the 1930s. When you think of all the miracles of modern medicine that have transformed healthcare in the last century here is something that touches all of our lives and it has been totally neglected."

A world-first female contraception developed by Professor Aitken's research group that simultaneously paralyses sperm and protects from sexually-transmitted diseases is currently undergoing safety trials.

Professor Aitken said the compound, which may eventually take the form of a sponge or vaginal ring, to be inserted two to three days before sexual intercourse, is activated only when in contact with semen.

"The invention is ground-breaking in that the compound does not kill sperm but targets their ability to swim, and is therefore much safer for women. If the chemical succeeds in both animal and human trials, it will be the first major advance in contraception since the pill was introduced more than five decades ago."

Professor Aitken said the discovery had the potential to address the global pandemic in sexually transmitted diseases. 

In addition to this potentially revolutionary contraception for women, Professor Aitken and his research team are chasing the holy grail – a male contraceptive pill.

"Male reproduction is much more complicated. You're not trying to stop the ovulation of one egg a month. You're trying to stop the production of a thousand sperm a second," he said.

"Our reproductive science group covers everything from conception, sperm and egg meeting one another and fertilising the egg and the very early stages of development all the way through to parturition and at both ends of the reproductive process there are pathological problems that we're interested in trying to solve."

Laureate Professor John Aitken in a research lab

Some of Professor Aitken's most notable achievements have been at the opposite end of the reproductive spectrum: assisting those with fertility issues. His speciality is the largely neglected field of male reproduction. 

While working at the University of Edinburgh in the late 1980s Professor Aitken uncovered a major cause of male infertility; molecules generated by smoking, obesity and age, known as free radicals, could attack sperm DNA. Today, thousands of men with infertility problems take antioxidants – the treatment against free-radical generation.

More recently he has developed a method for selecting the best sperm from ejaculate, which makes the process of sperm separation for in vitro fertilisation faster and more accurate.

"In assisted conception, the best sperm needs to be selected because it will impact the development potential of the embryo," he explains.

His research led to the development of a separating device called the CS10, manufactured in conjunction with life sciences company NuSep. Set for a commercial launch in 2015, it has the potential to snare a substantial share of the world market estimated to be worth more than $100 million a year.
Currently in Australia, one in 30 children is the product of Assisted Reproductive Technology (ART), however this achievement raises some issues.

By starting families later in life, Professor Aitken said people risk miscarriage and chromosomal diseases in their offspring.

"We live in strange times in having this strange dichotomy between people who are desperate to have pregnancies and those who are aborting their pregnancies," he said.

As the 2012 NSW Scientist of the Year Professor Aitken is urging a renewed focus on the development of 21st century methods of female contraception, more attention on the causes of male infertility and frank discussions about the increased use of ART as women delay having babies.

"We need to understand this headlong rush into ART is going to have a long-term impact on the health and well-being of future generations."

During the 40 years Professor Aitken has been working to uncover the intricacies of the union between sperm and egg he has published over 480 research articles, given more than 350 invited lectures and filed 12 patents. His work has been cited >16,000 times (h-index of 70), the highest citation index in his field.

Since arriving in Newcastle he has generated more than $37 million in research income and has been continuously funded by both the Australian Research Council (ARC) and the National Health and Medical Research Council (NHMRC). He has been elected a Fellow of both the Royal Society of Edinburgh and the Australian Academy of Science and is currently President of the International Society of Andrology.

The world-renowned reproductive biologist has worked and studied at some of the world's most prestigious research institutes including Cambridge and the World Health Organisation, but says there is no place he would rather be than Newcastle.

"The University of Newcastle is less than 50 years old and it's already in the top 3 per cent of the world's universities. That achievement is amazing and should be recognised as such. Universities are not bricks and mortar - universities are people and there are some fantastic people in this university and I'm very proud to be a member of that community.

"This is a very exciting time to be in Newcastle. It's changing very dramatically and the University will be a major force in driving the future development of the region."

Learn more about John and his work:

Meet other UON global leaders

Professor John Aitken

Giving birth to a better world

Laureate Professor John Aitken believes creating better methods of contraception and curing infertility are the two single most important issues facing the world - and this global authority on reproductive biology is leading the charge to achieve both. Professor Aitken,…

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A fertile mind

Finding better ways to regulate fertility has been a career crusade for Professor John Aitken.

It may have been the promise of better weather that first lured Laureate Professor John Aitken to Newcastle, but it is the intellectual challenge that has kept him here.

Aitken, a global authority on reproductive biology, arrived from the University of Edinburgh to take up a Chair in Biological Sciences in 1999. He is now a leader of a 150-strong research team studying fertility and contraception, which has attracted nearly $50 million in funding in that time.

"On a world scale, a team of 150 people working solely on reproductive science is significant. It is an enormous commitment by the University to the area, " says Aitken, a co-director of the University's Centre for Reproductive Science.

Reproduction has always fascinated Aitken. As an undergraduate in London studying zoology, he was intrigued by the "amazing process of how we start from a single cell and develop into an entire organism ".

Postgraduate studies in reproductive biology followed and by the age of 25 he was working with the World Health Organisation (WHO), overseeing a multi-million-dollar series of research projects into fertility regulation. It was a defining period in his career.

"The problems ailing our species – poverty, pestilence, war, famine – all have their root cause in unsustainable population growth, " the widely cited academic says.

"I concluded that the most pressing challenge for biologists is to determine how to control population growth. "

While the WHO experience gave him an insight into the need for more accessible and effective forms of contraception, some of Aitken's most notable achievements have been at the opposite end of the reproductive spectrum: assisting those who have problems with fertility. His speciality is the largely neglected field of the male reproduction.

"Our understanding of the male reproductive system is approximately 20 years behind our understanding of the female system. One in 20 men is infertile, yet we do not have a medical specialty in male reproduction, " he says.

Aitken, a recent inductee to the select group of Fellows of the Australian Academy of Science, has made some significant breakthroughs in the understanding of male fertility with his team at the centre.

He has developed a method of selecting the best sperm from ejaculate which makes the process of sperm separation for in vitro fertilisation faster and more accurate.

"In assisted conception, the best sperm needs to be selected because it will impact the development potential of the embryo, " he explains.Laureate Professor John Aitken speaking to researchers

"Our research found that the best sperm also carry the highest net negative charge. In our process, the sperm cells are placed in an electric field and those that move towards the anode (the positively charged electrode) are the 'good guys'.

"This separating process achieves in approximately five minutes a task that takes conventional technology about 45 minutes to complete."

The research led to the development of a separating device called the CS10, manufactured in conjunction with life sciences company NuSep. It is set for a commercial launch in 2012, following clinical trials, and has the potential to snare a substantial share of a world market estimated to be worth $100 million annually.

In another research project, he collaborated with colleague Dr Brett Nixon to discover that sterility in some men could be related to the absence of a 'chaperone' protein which is needed to allow sperm to recognise an egg cell.

"Biologically, sperm-egg union is a miracle; 200 million sperm cells are released into the female tract and they have to find one other cell in the body," Aitken says.

"The sperm-egg recognition process is akin to a gunslinger in the Wild West – the sperm keep their receptors for the egg in their 'holster' and only transport them to the surface as they hone in on the egg."

The process is orchestrated by the 'chaperone' proteins.  Among infertile men, the corralling of the receptors and their presentation on the surface of the cell does not occur due to the absence of chaperone proteins.

"Our research is trying to find out why these molecular proteins are missing, which will hopefully lead us back to the origins of the infertility."

In the area of fertility control, Aitken has received a donation from The Bill and Melinda Gates Foundation to research the development of a novel drug for use in developing countries that would both provide both contraception and protection against sexually transmitted diseases.

"I think better methods of fertility regulation and curing infertility are the two single most important issues facing the world," Aitken says.

"Every year the reproductive needs of 400 million couples go unmet. It is up to scientists working in public sector institutions such as Newcastle to make the breakthroughs that will lead to those new methods."

Laureate Professor John Aitken researches in collaboration with the Hunter Medical Research Institute's (HMRI) Pregnancy and Reproduction Program. HMRI is a partnership between the University, Hunter New England Local Health District and the community.

Visit the Centre for Reproductive Science website

Visit the HMRI website

Meet other UON global leaders

John Aitken

A fertile mind

Finding better ways to regulate fertility has been a career crusade for Professor John Aitken.

Read more

Career Summary

Biography

Laureate Professor Aitken’s research career began with a PhD in reproductive biology from the University of Cambridge. Following post-doctoral positions at the Institute of Animal Genetics, University of Edinburgh and the University of Bordeaux, he accepted an invitation to join the World Health Organization in Geneva, where he managed two WHO task forces within the Human Reproduction Unit. In 1977, he joined the Medical Research Council’s Reproductive Biology Unit, University of Edinburgh, to establish a research group in gamete biology with clinical outreach into male infertility. In 1992, John was awarded an Honorary Professorship within the Faculty of Medicine of Edinburgh University and 1998 he received an ScD degree from the University of Cambridge in recognition of his research contributions to gamete biology. In the same year he moved to the University of Newcastle, NSW, as Chair of Biological Sciences and, later, Director of the ARC Centre of Excellence in Biotechnology and Development. John has published over 480 research articles, given more than 350 invited lectures and filed 12 patents. His work has been cited >16,000 times (h-index of 69), the highest citation index in his field. Since arriving in Newcastle he has generated >$37 million in research income and has been continuously funded by both the ARC and the NHMRC. Examples of professional awards include the Walpole prize (Society for the Study of Fertility) in consecutive years (1986,1987), the Puvan Memorial Lecture (Royal Malaysian College of Obstetrics and Gynaecology) Bruce Stewart Memorial Lecture (American Society of Reproductive Medicine) the Amoroso lecture (the most prestigious award offered by the Society for the Study of Fertility) the Jennifer Hallam Memorial Lecture (Family Planning Association of the United Kingdom) and the MJ Edwards lecture (Australian Birth Defects Society). In 2003 he gave the Lloyd Cox Memorial oration to the University of Adelaide, and in 2004 delivered the Founders Lecture (the most prestigious award offered by the Society for Reproductive Biology) at a combined meeting of the SRB and the Endocrine Society of Australia in Sydney. In 2005 he received the ST Huang-Chan Memorial Medal from the University of Hong Kong, was appointed a Laureate Professor by the University of Newcastle and received the 2005 Scientist-of-the-Year award from the Hunter Medical Research Institute. In 2006 he delivered the Keynote Address to the American Society of Andrology meeting in Chicago and a Plenary Lecture to the Fertility Society of Australia. He also presented a Keynote Address at the 2007 Frontiers in Bioscience Symposium, to celebrate the 120th anniversary of the Faculty of Medicine, University of Hong Kong. In 2009 he delivered the Inaugural Dame Anne McLaren Memorial Lecture at the Fertility 2009 Congress in Edinburgh and in 2010 was selected to present ‘The Yanagamachi Lecture’ to the University of Hawaii and the ‘IJA lecture’ (the most prestigious ward offered by the European Academy of Andrology) to the European Congress of Andrology in Athens. In 2012 he received the Simmet Prize, the highest honour bestowed by the International Congress on Animal Reproduction, at the ICAR meeting in Vancouver, presented the Ian Johnston Memorial lecture on behalf of the Fertility Society of Australia at their annual meeting in October and was named as the NSW Scientist-of-the-year. At an international meeting in Okinawa last year he was also elected Chairman and convenor of the 12th International Symposium of Spermatology, which will be held in Newcastle in 2014. He has also been elected a Fellow of both the Royal Society of Edinburgh and the Australian Academy of Science and is currently President of the International Society of Andrology. John Aitken is on the Editorial Boards of 8 journals at the present time and he is also Chairman of two Scientific Advisory Boards in the healthcare sector.

Research Expertise
My area of expertise is cell biology and biotechnology with particular emphasis on reproductive science. I am Director of the PRC for Reproductive Science as well as the ARC Centre of Excellence in Biotechnology and Development. In recent years my focus has been on the cell biology of mammalian germ cells, particularly the male. This interest extends from the fundamental molecular mechanisms that regulate the differentiation of male germ cells in the testes to the development of clinical improvements in our capacity to diagnose and treat male infertility. My laboratory has pioneered the proteomic analyses of spermatozoa and oocytes and has just released the first inventory of proteins comprising the human sperm proteome into the public domain. We have also been instrumental in developing techniques for the identification of spermatogonial stem cells and in defining key elements of the developmental niches that both preserve these cells stem cell status and drive some of their daughter cells to differentiation and the ultimate morphogenesis of spermatozoa. The functional maturation of spermatozoa in the epididymis and their subsequent capacitation in the female tract have also been a key point of interest for our laboratory. In the course of these studies we have proposed novel models for the control of mammalian sperm function based on the selective the partitioning of key proteins into lipid rafts on the sperm plasma membrane. Clinically, we have pioneered the notion that oxidative stress plays a key role in the aetiology of defective sperm function as well as DNA damage in the male germ line. These studies have lead to new developments in the treatment of such patients that are now beginning to enter clinical practice.

Teaching Expertise
The emphasis of my teaching activities has been in the area of postgraduate teaching particularly with respect to the supervision of Honours, MSc and PhD students. I am co-ordinator for the MSc-by-research degree offered by the Faculty of Science and IT. I have also participated in the teaching of biological sciences at 1st, 2nd and 3rd year levels. Currently, I lecture to first year biology students and assist in the delivery of a 3rd year course on Reproductive Physiology.

Administrative Expertise
I am Director of the ARC Centre of Excellence in Biotechnology and Development, Co-Director of the Priority Research Centre in Reproductive Science and Professor of Biological Sciences at the University of Newcastle. I am a member of the University of Newcastle Research Portfolio Committee, the Biomedical Research Fund Committee, the Faculty of Science and IT Research Committee and the Executive of the School of Environmental and Life Sciences.

Collaborations
Collaborating colleagues outside of the University of Newcastle with whom we share reagents and expertise include: Prof Lois Salmonsen, Dr Pater Stanton, Prof Rob McLachlan (Prince Henry’s Research Institute, Melbourne) Prof Moira O’Bryan (Monash University ) Prof Sarah Robertson, Prof Rob Norman (University of Adelaide) Prof Mike Holland (University of Queensland) Prof Peter Koopman (University of Queensland) Prof Ken Beagley (Queensland University of Technology) Prof Susan Suarez (Cornell University) Prof Steven Ward, Prof Monica Ward (University of Hawaii) Prof Joel Drevet (University Blaise Pascal) Prof B. Gadella (University of Utrecht) Prof Nuch Tanphaichitr (University of Ottawa) Current collaborating agencies include: NuSep: a biotechnology company based in Sydney who are commercializing an electrophoretic sperm isolation device developed by John for assisted conception purposes in man an animals IVF companies: IVF Australia, Fertility First, Hunter IVF and Westmead Fertility Centre, partners in the development of novel approaches for the diagnosis and treatment of male infertility Bayer-Schering-Pharma: this company has developed Sptrx KO mice (sperm specific thioredoxins) which are now being analysed by John’s research group. Bayer Healthcare: John is Chairman of the Menevit Scientific Advisory Board and advises the company on the development of antioxidant therapy for male infertility CellOxess, New Jersey: collaborating on the development of antioxidant formulations for treating equine infertility Hunter Valley Equine Research Centre are partnering the Aitken laboratory in a research initiative designed to develop novel methods for the diagnosis of infertility in Thoroughbred stallions. Harness racing Australia are partnering the Aitken laboratory in a research initiative designed to deliver improved methods of extending and cryopreserving semen from Standardbred stallions. CONRAD (Contraceptive Research and Development Branch of the US Agency for International Development): partnering the Aitken laboratory in the area of contraceptive development Bill and Melinda Gates Foundation: partners in the development of novel approaches to contraception and the control of sexually transmitted disease.


Qualifications

  • Doctor of Science, University of Cambridge - UK
  • Bachelor of Science, University of London
  • PhD, University of Cambridge - UK
  • Master of Science, University of Wales

Keywords

  • Biotechnology
  • Cell Biology
  • Fertility regulation
  • Gamete Biology
  • Infertility
  • Reproductive Biology
  • Reproductive Sciences

Fields of Research

CodeDescriptionPercentage
060699Physiology not elsewhere classified15
060199Biochemistry and Cell Biology not elsewhere classified35
111499Paediatrics and Reproductive Medicine not elsewhere classified50

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2014 - ProfessorUniversity of Newcastle
School of Environmental and Life Sciences
Australia

Academic appointment

DatesTitleOrganisation / Department
Scientific Advisory Board - CSIRO /CRC for the Biological Control of Pest Animal Species CSIRO /CRC for the Biological Control of Pest Animal Species
Australia
Scientific Advisory Board - Hunter Medical Research InstituteHunter Medical Research Institute (HMRI)
Australia
Scientific Advisory Board - Andrology AustraliaAndrology Australia
Australia
1/01/2013 - PresidentInternational Society of Andrology
Australia
1/01/2013 - Editorial Board - Reproductive Biomedicine Online Journal Reproductive Biomedicine Online Journal
Australia
1/01/2013 - Editorial Board - Andrology JournalAndrology Journal
Australia
1/01/2012 - Fellow - Society for Reproductive Biology Society for Reproductive Biology
Australia
1/01/2011 - Editorial Board - Spermatogenesis Journal Spermatogenesis Journal
Australia
1/01/2010 - Editorial Board - Asian Journal of AndrologyAsian Journal of Andrology
Australia
1/01/2007 - 31/12/2013Editorial Board - Journal of AndrologyJournal of Andrology
Australia
1/01/2007 - Editorial Board - Reproduction JournalReproduction Journal
Australia
1/05/2005 - Laureate ProfessorUniversity of Newcastle
Australia
1/01/2005 - Editorial Board - Molecular Human Reproduction JournalMolecular Human Reproduction Journal
Australia
1/01/2003 - 31/12/2010Editor - ARC Centre of Excellence in Biotechnology and DevelopmentARC Centre of Excellence in Biotechnology and Development
Australia
1/01/2003 - 1/12/2010Director, ARC Centre of ExcellenceUniversity of Newcastle
School of Environmental and Life Sciences
Australia
1/01/1999 - 1/01/2002Head of SchoolUniversity of Newcastle
School of Environmental and Life Sciences
Australia
1/09/1998 - Professor of Biological SciencesUniversity of Newcastle
Australia
1/01/1995 - Fellow - Royal Society of EdinburghRoyal Society of Edinburgh
United Kingdom
1/01/1987 - 1/09/1998Special AppointmentMedical Research Council of the United Kingdom
MRC Reproductive Biology Unit
United Kingdom

Membership

DatesTitleOrganisation / Department
Co-Director - Priority Research Centre in Reproductive SciencePriority Research Centre in Reproductive Science
Australia
Co-Director - Mothers and Babies Research GroupMothers and Babies Research Group
Australia
1/01/2010 - 31/12/2013Membership - Project Grant CommitteeNHMRC (National Health & Medical Research Council)
Australia

Awards

Honours

YearAward
2007The Jennifer Hallum Memorial Lecture
Family Planning Association
2007Honorary Professorship
University of Edinburgh
2006The 2006 Keynote Address to the American Society of Andrology, Chicago. From proteomics to peroxidat
American Society of Andrology
2005ST Huang-Chan Memorial Lecture and Medal
The University of Hong Kong
2005The 2005 Monash Industry Engagement Award
Monash University
20052005 Scientist-of-the-year
Hunter Medical Research Institute
2004Founder's Lecture
Society for Reproductive Biology
2003Lloyd Cox Oration
University of Adelaide
1999M.J. Edwards Lecture
Australian Birth Defects Society
1998Amoroso Lecture
Society for Reproduction and Fertility
1990The Puvan Memorial Lecture
Obstetrical and Gynaecological Society of Malaysia (OGSM)
1989University of Catania Prize
University of Catania

Recognition

YearAward
2013NSW Scientist of the year
Office of the NSW Chief Scientist and Engineer

Research Award

YearAward
2011Excellence in Innovation
Newcastle Innovation
2006 2006 Faculty Award for Research Excellence
University of Newcastle
1987Walpole Prize
Society for Reproduction and Fertility
1986Walpole Prize
Society for Reproduction and Fertility

Invitations

Keynote Speaker

YearTitle / Rationale
2013Keynote Address to Frontiers in Bioscience Symposium
Organisation: University of Hong Kong Description: Keynote Address. Frontiers in Bioscience Symposium to celebrate the 120th anniversary of the Faculty of Medicine, University of Hong Kong
2013The Ian Johnston Memorial Lecture
Organisation: Fertility Society of Australia Description: The Ian Johnston Memorial Lecture, Fertility Society of Australia, Aukland. Moat prestigious award by the Fertility Society of Australia.
2013Keynote Speaker
Organisation: Canberra Health Annual Research Annual Meeting (CHARM) Description: Keynote speaker. Canberra Health Annual Research Annual Meeting (CHARM) Canberra Hospital Auditorium, Canberra
2013Keynote Speaker
Organisation: Centre for Reproduction and Genomics 5th Annual Colloquium, University of Otago Description: Keynote speaker. Centre for Reproduction and Genomics 5th Annual Colloquium, University of Otago, New Zealand.
2011The 2011 International Plenary lecturer.
Organisation: Physiology Society of Southern Africa Description: The 2011 International Plenary lecturer. Physiology Society of Southern Africa. 39th Annual Conference, Cape Town
2010The Yanagimachi Lecture
Organisation: University of Hawaii Description: The Yanagimachi Lecture. Lives in the balance: apoptosis, prosurvival factors and DNA damage in the male germ line. An annual lecture delivered to the University of Hawaii in honour of Professor Yanagimachi. University of Hawaii.
2010Keynote lecture
Organisation: Australian Medical Students Association Description: Australian Medical Students Annual Congress, Convertion Centre, Hobart, Tasmania.
2010The IJA Lecture
Organisation: European Academy of Andrology Description: The IJA Lecture. Most prestigious award given by European Academy of Andrology as a biannual lecture. Plenary lecture to European Congress of Andrology meeting in Athens., Greece
2009Graeme Clark Outcomes Forum
Organisation: Australian Research Council Description: Graeme Clark Outcomes Forum celebrating ARC funded technology. Parliament House Canberra.
2009The Inaugural Anne McLaren Memorial Lecture
Organisation: British Fertility Society Description: The Inaugural Anne McLaren Memorial Lecture. Advances in sperm cell biology. International Congress ‘Fertility 2009’, Edinburgh International Conference Centre, UK
2009The 2009 Merck Serono Plenary lecture
Organisation: WA Endocrine Society Description: The 2009 Merck Serono Plenary lecture. Assisted conception in the treatment of male infertility – a healthy start to life? The WA Endocrine and Reproductive Sciences Symposium. QE11 Medical Centre, Perth, WA.
2006The American Andrology Society Keynote Lecture
Organisation: American Andrology Society Description: The American Andrology Society Keynote Lecture. ASA Annual Meeting Chicago
2005 Plenary Lecture
Organisation: Australian Society for Medical Research Description: 2005 Plenary Lecture to the Australian Society for Medical Research, Adelaide. ‘’The loneliness of the long distance runner’.
2004The Founders Lecture
Organisation: Society for Reproductive Biology Description: The 2004 Founder’s Lecture. Most prestigious annual lecture awarded by the Society for Reproductive Biology. Presented at the Joint Annual Scientific Conference with the Endocrine Society of Australia, Darling Harbour Convention Centre, Sydney. Fruits of Creation Seeds of Doubt
2003Plenary Lecture, Endocrine Society of Australia
Organisation: Endocrine Society of Australia Description: Plenary Lecture. The human testes; engine of evolution and progenitor of disease. Endocrine Society of Australia, Annual Meeting, Noosa, QLD.
2003The 2003 Lloyd Cox Memorial Lecture
Organisation: University of Adelaide Description: The 2003 Lloyd Cox Memorial Lecture. Annual Oration to the Faculty of Medicine, University of Adelaide. The male germ line and its part in our downfall.
2002Plenary Lecture, IXth World Congress on Human Reproduction
Organisation: IXth World Congress on Human Reproduction Description: Plenary Lecture. Global trends in male fertility. IXth World Congress on Human Reporoduction, Montreal, Canada.
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Book (6 outputs)

YearCitationAltmetricsLink
2012Agarwal A, Aitken RJ, Alvarez JG, Studies on Men's Health and Fertility, Springer, New York, 671 (2012) [A3]
2010Habenicht U-F, Aitken RJ, Fertility Control, Springer, Heidelberg, Germany, 263 (2010) [A3]
2004Aitken RJ, Hinton BT, Orgebin-Crist M-C, Male Contraception: A Choice on the Horizon, Elsevier, Amsterdam, 94 (2004) [A3]
1992unknown, World Health Organization Laboratory Manual for the Examination of Human Semen, Cambridge University Press, Cambridge (1992)
1987Aitken RJ, World Health Organization Laboratory Manual for the Examination of Human Semen, Cambridge University Press, Cambridge (1987)
1987Aitken RJ, World Health Organization Laboratory Manual for the Examination of Human Semen, Cambridge University Press, Cambridge (1987)
Show 3 more books

Chapter (81 outputs)

YearCitationAltmetricsLink
2013Baker MA, Aitken RJ, 'Mass Spectrometry proteomics and the study of sperm cell biology', Human Gametes and Preimplantation Embryos, Springer, New York, NY 193-203 (2013) [B1]
DOI10.1007/978-1-4614-6651-2_18
Co-authorsMark Baker
2012Perreault SD, Aitken RJ, Gordon Baker HW, Evenson DP, 'Integrating new tests of sperm genetic integrity into semen analysis: Breakout group discussion', Advances in Male Mediated Developmental Toxicity, Springer, New York, USA 253-268 (2012)
2012De Iuliis GN, King BV, Aitken RJ, 'Electromagnetic radiation and oxidative stress in the male germ line', Studies on Men's Health and Fertility, Springer, New York 3-20 (2012) [B1]
Co-authorsGeoffry DeiuliIs, Bruce King
2012Alvarez JG, Aitken RJ, 'Lipid peroxidation in human spermatozoa', Studies on Men's Health and Fertility, Springer, New York 119-130 (2012) [B1]
2012Aitken RJ, De Iuliis GN, Baker MA, 'Direct methods for the detection of reactive oxygen species in human semen samples', Studies on Men's Health and Fertility, Springer, New York 275-299 (2012) [B1]
Co-authorsGeoffry DeiuliIs, Mark Baker
2012Redgrove KA, Aitken RJ, Nixon B, 'More than a simple lock and key mechanism: unraveling the intricacies of sperm-oocyte interactions', Binding Protein, InTech, Rijeka, Croatia 73-122 (2012) [B1]
DOI10.5772/2897
Co-authorsBrett Nixon
2011Aitken RJ, 'Sperm selection for assisted conception', How to Improve Your ART Success Rates: An Evidence-Based Review of Adjuncts to IVF, Cambridge University Press, Cambridge 127-132 (2011) [B1]
2011Aitken RJ, De Iuliis GN, 'Role of oxidative stress in the etiology of sperm DNA damage.', Sperm Chromatin: biological and clinical applications in male infertility, Springer, New York, USA 277-294 (2011) [B2]
2011Fleming S, Aitken RJ, 'Electrophoretic sperm separation', Sperm Chromatin, Springer, New York, USA 423-430 (2011) [B2]
2011Aitken RJ, 'Foreword: A healthy start to life', Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction, Springer, New York, USA (2011)
2011Aitken RJ, Curry BJ, 'Life and death in the germ line: Apoptosis and the origins of dna damage in human spermatozoa', Principles and Practice of Fertility Preservation, Cambridge University Press 101-113 (2011) [B2]

Introduction apoptosis and DNA damage in human spermatozoa Apoptosis, a physiological process for the controlled deletion of cells, is critical for the regulation of cell numbers, the management of morphogenesis during embryonic development and the orchestration of many cellular processes in the adult. Spermatogenesis, the production of functional spermatozoa from spermatogonial stem cells is no exception. It appears that a functional apoptotic pathway is necessary for normal spermatogenesis to develop and without it infertility ensues. Apoptosis also plays a crucial role in the maintenance of the testis and its response to external toxicants as well as in the programmed senescence of terminally differentiated spermatozoa. This chapter will focus specifically on how apoptosis affects sperm quality and function, and the implications of this process for both embryonic development and the health and well-being of the offspring. A great deal of data has accumulated in recent years suggesting that human spermatozoa can exhibit some of the hallmarks of apoptosis including activation of caspases 1, 3, 8 and 9 [1, 2], annexin-V binding [3, 4], mitochondrial generation of reactive oxygen species (ROS) [5] and DNA fragmentation [6¿8]. The latter is potentially extremely important because DNA damage in the male germ line has been associated with a wide variety of adverse biological and clinical outcomes. Thus DNA damage in human spermatozoa has been correlated with poor fertilization and impaired embryonic development to the blastocyst stage [9, 10] as well as with the incidence of subsequent miscarriage [11¿13].

DOI10.1017/CBO9780511921896.012
Co-authorsBen Curry
2010Aitken RJ, Baker MA, De Iuliis GN, Nixon B, 'New insights into sperm physiology and pathology', Fertility Control, Springer, Berlin 99-115 (2010) [B1]
CitationsScopus - 23
Co-authorsMark Baker, Brett Nixon, Geoffry DeiuliIs
2010Dun MD, Mitchell LA, Aitken RJ, Nixon B, 'Sperm-zona pellucida interaction: Molecular mechanisms and the potential for contraceptive intervention', Fertility Control, Springer, Berlin 139-178 (2010) [B1]
CitationsScopus - 4
Co-authorsMatt Dun, Brett Nixon
2008Aitken RJ, Roman SD, 'Antioxidant systems and oxidative stress in the testes', Molecular Mechanisms in Spermatogenesis, Landes Bioscience, Austin, Texas 154-171 (2008) [B1]
CitationsWeb of Science - 25
Co-authorsShaun Roman
2007Aitken RJ, Bennetts LE, 'Reactive oxygen species and their impact on fertility', Male Infertility: Diagnosis and Treatment, Informa, Zug, Switzerland 255-268 (2007) [B1]
2007Aitken RJ, Roman SD, Baker MA, De Iuliis GN, 'Redox regulation of DNA damage in the male germ line', Male-Mediated Developmental Toxicity, Royal Society of Chemistry, London, United Kingdom 197-209 (2007) [B1]
CitationsWeb of Science - 2
Co-authorsShaun Roman, Mark Baker, Geoffry DeiuliIs
2006Aitken RJ, Bennetts LE, 'Reactive oxygen species: friend or foe', The Sperm Cell: Production, Maturation, Fertilization, Regeneration, Cambridge University Press, Cambridge 170-193 (2006) [B1]
CitationsScopus - 6
2004Aitken RJ, 'Laboratory assessment of the infertile man', Good Clinical Practice in Assisted Reproduction, Cambridge University Press, Cambridge, UK 59-85 (2004) [B1]
2002Aitken RJ, 'Active oxygen in spermatozoa during epididymal transit', The Epididymis from molecules to clinical practice., Klewer Academic / Plenum Publishers, New York 435-449 (2002) [B1]
2002Aitken RJ, Sawyer DE, 'The human spermatozoon: Not waving but drowning', Advances in Male Mediated Developmental Toxicity, Kulwer Academic, New York 85-98 (2002) [B1]
CitationsScopus - 57Web of Science - 1
2002Perreault SD, Aitken RJ, Baker HWG, Evenson DP, Huszar G, Irvine DS, et al., 'Integrating new tests of sperm genetic integrity into semen analysis: Breakout group discussion', Advances in Male Mediated Developmental Toxicity, Kulwer Academic, New York 253-268 (2002) [B1]
CitationsScopus - 77
2002Aitken RJ, 'Tests of male fertility', Asisted Reproductive Technology, Cambridge University Press, Cambridge, UK 255-271 (2002) [B1]
2001Aitken RJ, 'Fertility: Immunological Control', Encyclopedia of Life Sciences, John Wiley & Sons, online 0-0 (2001)
DOI10.1038/npg.els.0000515
2000Jeffries DJ, Aitken RJ, 'SPERMICIDES AND VIRUCIDES', CONDOMS, BMJ PUBLISHING GROUP, LONDON WCIH 9JR 85-96 (2000) [B1]
1999Aitken RJ, 'Production and effects of reactive oxygen species by spermatozoa. In: Reactive Oxygen Species in Biological Systems: An Interdisciplinary Approach', Reactive Oxygen Species in Biological Systems: An Interdisciplinary Approach, Plenum Publishing Corporation, New York, USA 527-541 (1999)
1998Aitken RJ, 'Assessment of semen quality. In: Treatment of Infertility : the New Frontiers', Treatment of Infertility : the New Frontiers, Communications media for Education Inc., unknown 0-0 (1998)
1997Aitken RJ, 'Leukocytospermia, oxidative stress and sperm function. In Male Infertility and Sexual Dysfunction', Male Infertility and Sexual Dysfunction, Springer Verlag, Heidelberg 100-109 (1997)
1996Irvine DS, Aitken RJ, 'Reactive oxygen species in the context of diagnostic andrology.', Spermatozoa in Assisted Conception, Parthenon Press, London 265-275 (1996)
1996gomez E, Irvine D, Aitken RJ, 'Diagnostico de la funcion espermatica', Reproduccion Humana, McGraw Hill Interamericana, Madrid 101-119 (1996)
1996Aitken RJ, 'Fertilisation and Early Embryogenesis', Scientific essentials of reproductive medicine, Saunders, London 219-229 (1996)
1996Aitken RJ, 'Sperm maturation and oocyte interaction. In: Manual of Assisted Conception', Manual of Assisted Conception, Springer, Verlag, Heidelberg 3-11 (1996)
1995Paterson M, Kerr L, Aitken RJ, 'Progress in characterization of zona pellucida antigens as candidates for birth control vaccine', Immunology of human reproduction, BIOS Scientific Publishers, Oxford 485-501 (1995)
1995Aitken RJ, 'Cell biology of human spermatozoa', The Spermatozoon, Cambridge Reviews in Human Reproduction, Cambridge University Press, Cambridge 206-237 (1995)
1995Aitken RJ, 'Mechanisms and prevention of lipid peroxidation in human spermatozoa', The acrosome reaction, physiological and pharmacological induction and transduction pathways, John Libbey Eurotext Ltd, Montrouge, France 339-353 (1995)
1995Paterson M, Aitken RJ, 'The zona pellucida', The Oocyte, Cambridge Reviews in Human Reproduction, Cambridge University Press, Cambridge 357-375 (1995)
1995Aitken RJ, 'Reactive oxygen species and sperm function. In Oxidative Stress in Male Infertility', Oxidative Stress in Male Infertility, CRC PressI Llc, St Augustin 41-56 (1995)
1995Aitken RJ, Saxty B, Paterson M, Kerr L, 'Anti-gamete antibodies', Immunocontraception, Serono Symposia Series, unknown 137-150 (1995)
1994Aitken RJ, 'The biochemistry and physiology of human spermatozoa, consequences for fertility and sterility', The Biological Basis of Early Human Reproductive Failure, Oxford University Press, USA, Oxford 252-282 (1994)
1994Aitken RJ, 'New methods for the diagnosis of defective sperm function and implications for treatment', Clinical Practice in Andrology, Springer Verlag, Berlin, New York 75-104 (1994)
1994Van Duin M, Thillai Koothan P, Paterson M, Aitken RJ, 'Immunocontraception by vaccination with the zona pellucida glycoprotein ZP3, from antigen identification and gene cloning towards vaccine development', Contraception Research and Development, Wiley Eastern Ltd, Bombay 221-235 (1994)
1993Richardson DW, Aitken RJ, 'Techniques for examining the fertilizing capacity of semen', Donor Insemination, Cambridge University Press, Cambridge 50-70 (1993)
1993Aitken RJ, 'Semen analysis and sperm function', Approach to clinical andrology (An), Serono Symposia Review No. 29, Rome 23-30 (1993)
1993Buntschoten H, Hepp E, Aitken RJ, 'Anti-sperm monoclonal antibodies useful in the development of an immunocontraceptive vaccine, their specificities and in vitro contraceptive activity', Modern Approaches to New Vaccines Including Prevention of AIDS, Cold Spring Laboratory Press, New York, USA 31-36 (1993)
1993Aitken RJ, Paterson M, Thillai K, 'Risks and benefits of immunological contraception', Spermatogenesis, fertilization contraception. Molecular, cellular and endocrine events in male reproduction, Springer Verlag, Berlin, New York 461-476 (1993)
1992Aitken RJ, 'Diagnosis of male infertility', Infertility. Royal College of Obstetricians and Gynaecologists Study Group, Springer Verlag, Berlin 81-101 (1992)
1991Aitken RJ, 'Future prospects for family planning', Handbook of Family Planning, Churchill Livingstone, Edinburgh 435-450 (1991)
1991Aitken RJ, 'Reactive oxygen species and human sperm function', Comparative spermatology 20 years after, Raven Pr, New York 787-792 (1991)
1991Aitken RJ, 'Evaluation of the 50 Hz PAL Version of the Hamilton Thorn motility analyser', Comparative spermatology 20 years after, Raven Press, New York 781-786 (1991)
1990Aitken RJ, 'Cell biology of the human spermatozoon', Proceedings of 7th Renier de Graaf Symposium, Ovulation to Implantation, Elsevier, Amsterdam 167-176 (1990)
1990Aitken RJ, 'Reactive oxygen species and human sperm function', NATO Advanced Workshop on Mechanisms of Fertilization, Plants to Humans. Nato series of cell biology, Springer-Verlag, Berlin 179-188 (1990)
1990Aitken RJ, 'Motility Parameters and Fertility', Controls of Sperm Motility, CRC Press, Boca Raton, Florida 285-302 (1990)
1989Aitken RJ, 'La Fecondance du sperme, donnees physiologiques', Aspects masculines des procreations medicalement assistees, Doin Press, Paris 17-30 (1989)
1989Aitken RJ, 'Assessment of human sperm function', The testes, 2nd edition, Raven Press, New York 441-474 (1989)
1988Wu FCW, Aitken RJ, 'Suppression of sperm function in steroid male contraception', The Molecular and Cellular Endocrinology of the Testis, Raven Press, New York 225-230 (1988)
1988Aitken RJ, 'The role of reactive oxygen species in the aetiology of male infertility', The Molecular and Cellular Endocrinology of the Testis, Raven Press, New York 193-202 (1988)
1988Aitken RJ, Irvine DS, Clarkson JS, Richardson DW, 'Development of in vitro systems for the diagnosis of human sperm function', Advances in Clinical Andrology, Mtp Press, Lancaster 99-112 (1988)
1987Aitken RJ, Clarkson JS, 'Generation of reactive oxygen species by human spermatozoa', Free Radicals, Recent Developments in Lipid Chemistry, Experimental Pathology and Medicine, Richelieu Press, London 333-355 (1987)
1987Aitken RJ, Clarkson JS, Huang GF, Irvine DS, 'Cell Biology of Defective Sperm Function', Recent Advances in Spermatology, Japanese Scientific Societies Press, Tokyo 75-90 (1987)
1986White DR, Aitken RJ, 'Sulphasalazine as a male contraceptive agent', Male Contraception, Advances and Future Prospects, HarperCollins Publishers, New York 227-237 (1986)
1986Aitken RJ, Irvine S, Clarkson JS, Richardson DW, 'Predictive value of in vitro sperm function tests', Male Contraception, Advances and Future Prospects, HarperCollins Publishers, New York 138-151 (1986)
1986Aitken RJ, 'A review of the molecular and cellular biology of fertilization', Advances in experimental medicine and biology, Plenum Press, New York 634-634 (1986)
1986Aitken RJ, 'Andrology and semen preparation for IVF', In Vitro Fertilization, Past, Present and Future, IRL Press, Oxford 89-106 (1986)
1986Aitken RJ, 'Use of sperm-ova penetration tests to evaluate the infertile couple', Male sexual dysfunction. Diagnosis and management of hypogonadism, infertility and impotence, Marcel Dekker Inc., New York 267-294 (1986)
1986Aitken RJ, 'A review of Development Biology', Manipulation of mammalian development, Plenum Pub Corp, New York 0-0 (1986)
1985Aitken RJ, Richardson DW, Clarkson DW, 'Assessment of the fertilizing capacity of human spermatozoa', In Vitro Fertilization and Donor Insemination, Royal College of Obstetricians and Gynaecologists, London 275-284 (1985)
1985Aitken RJ, 'Measurement and manipulation of human sperm function, biological and immunological aspects', La fecondation humaine in vitro. Problems actuels et perspectives, Elsevier Press, Amsterdam 123-134 (1985)
1984Aitken RJ, Richardson DW, Hulme MJ, 'Immunological interference with the properties of the zona pellucida', Immunological aspects of reproduction in mammals, Butterworth-Heinemann, London 305-325 (1984)
1984Aitken RJ, 'Clinical assessment of human sperm function', Human in vitro fertilization and early human development, CIC Press, Rome 103-112 (1984)
1983Aitken RJ, Templeton A, Schats R, Best F, 'Methods for assessing the functional capacity of human spermatozoa; their role in the selection of patients for in vitro fertilication', Fertilization of the Human Egg in Vitro, Springer Verlag, Berlin 147-165 (1983)
1983Aitken RJ, 'The zona free hamster egg penetration test', Male Infertility Clinical Practice in Urology, Springer-Verlag, Berlin 75-86 (1983)
1983Aitken RJ, Best FSM, Templeton AA, 'Fertilizing capacity of human spermatozoa, a study of oligozoospermia and unexplained infertility', Recent Advances in Male Reproduction, Molecular Basis and Clinical Applications, Raven Press, New York 13-25 (1983)
1983Aitken RJ, 'New techniques in contraception, gossypol, vaccines and GnRH analogues', Developments in Human Reproduction and Their Eugenic, Ethical Implications, Academic Press, London 1-18 (1983)
1983Aitken RJ, 'Attributes and applications of the zona free hamster egg penetration test', In vitro fertilization and embryo transfer, Academic Press, London 167-193 (1983)
1982Aitken RJ, 'The contraceptive potential of antisperm antibodies', Progress Towards a Male Contraceptive, Wiley & Sons, Chichester 109-134 (1982)
1981Aitken RJ, 'The control of blastocyst activity', Proteins and steroids in early pregnancy, Springer-Verlag, Berlin 223-244 (1981)
1980Aitken RJ, 'Interactive events in early pregnancy', Animal Models in Human Reproduction, Raven Press (ID), New York 299-317 (1980)
1980Aitken RJ, Richardson DW, 'Immunization against zona pellucida antigens', Immunological aspects of reproduction and fertility control, Springer London, Lancaster 173-201 (1980)
1979Aitken RJ, Beaconsfield R, Ginsburg V, 'Origin and formation of the placenta', Placenta - a neglected experimental animal, Pergamon Press, Oxford 152-163 (1979)
1979Aitken RJ, 'Uterine proteins', Oxford Reviews of Reproductive Biology, Oxford University Press, Oxford 351-382 (1979)
1978Aitken RJ, Bonnin M, Canivenc R, 'Lethargie et activation du blastocyste', L'implantation de loeuf, Masson, Paris 255-272 (1978)
1977Aitken RJ, 'Embryonic diapause', Development in mammals, Elsevier Press, Amsterdam 307-360 (1977)
Show 78 more chapters

Journal article (433 outputs)

YearCitationAltmetricsLink
2015Lord T, Martin JH, Aitken RJ, 'Accumulation of Electrophilic Aldehydes During Postovulatory Aging of Mouse Oocytes Causes Reduced Fertility, Oxidative Stress, and Apoptosis', BIOLOGY OF REPRODUCTION, 92 (2015)
DOI10.1095/biolreprod.114.122820Author URL
2015Kongmanas K, Kruevaisayawan H, Saewu A, Sugeng C, Fernandes J, Souda P, et al., 'Proteomic Characterization of Pig Sperm Anterior Head Plasma Membrane Reveals Roles of Acrosomal Proteins in ZP3 Binding', JOURNAL OF CELLULAR PHYSIOLOGY, 230 449-463 (2015)
DOI10.1002/jcp.24728Author URL
CitationsScopus - 1Web of Science - 1
Co-authorsMark Baker
2015Varner DD, Gibb Z, Aitken RJ, 'Stallion fertility: A focus on the spermatozoon', Equine Veterinary Journal, 47 16-24 (2015)

Stallion fertility is a vast subject, with a wide array of permutations that can impact reproductive performance in either positive or negative ways. This review is intended to address a mere segment of the male fertility issue, but the very essence of the male contribution to fertilisation, that of the spermatozoon. Spermatozoal ultrastructure and form-to-function are detailed and spermatozoal metabolism is discussed, with specific reference to distinctive characteristics of stallion spermatozoa. Lastly, methods for assessment of spermatozoal function are considered, with emphasis on spermatozoal motility, the acrosome reaction and spermatozoon-oocyte interactions. Closing comments address the need for development and standardisation of molecular-based assays for use with spermatozoa of stallions whose subfertility cannot be explained with conventional tests.

DOI10.1111/evj.12308
2015Varner DD, Gibb Z, Aitken RJ, 'Stallion fertility: A focus on the spermatozoon', Equine Veterinary Journal, 47 16-24 (2015)
DOI10.1111/evj.12308
2015Swegen A, Curry BJ, Gibb Z, Lambourne SR, Smith ND, Aitken RJ, 'Investigation of the stallion sperm proteome by mass spectrometry', Reproduction, 149 235-244 (2015)

Stallion spermatozoa continue to present scientific and clinical challenges with regard to the biological mechanisms responsible for their survival and function. In particular, deeper understanding of sperm energy metabolism, defence against oxidative damage and cell-cell interactions should improve fertility assessment and the application of advanced reproductive technologies in the equine species. In this study, we used highly sensitive LC-MS/MS technology and sequence database analysis to identify and characterise the proteome of Percoll-isolated ejaculated equine spermatozoa, with the aim offurthering our understanding of this cell's complex biological machinery. We were able to identify 9883 peptides comprising 1030 proteins, which were subsequently attributed to 975 gene products. Gene ontology analysis for molecular and cellular processes revealed new information about the metabolism, antioxidant defences and receptors of stallion spermatozoa. Mitochondrial proteins and those involved in catabolic processes constituted dominant categories. Several enzymes specific to ß-oxidation of fatty acids were identified, and further experiments were carried out to ascertain their functional significance. Inhibition of carnitine palmitoyl transferase 1, a rate-limiting enzyme of ß-oxidation, reduced motility parameters, indicating that b-oxidation contributes to maintenance of motility in stallion spermatozoa.

DOI10.1530/REP-14-0500
Co-authorsBen Curry
2015Purdey MS, Connaughton HS, Whiting S, Schartner EP, Monro TM, Thompson JG, et al., 'Boronate probes for the detection of hydrogen peroxide release from human spermatozoa', Free Radical Biology and Medicine, 81 69-76 (2015)

Human spermatozoa are compromised by production of reactive oxygen species (ROS), and detection of ROS in spermatozoa is important for the diagnosis of male infertility. The probes 2',7'-dichlorohydrofluorescein diacetate (DCFH), dihydroethidium (DHE), and MitoSOX red (MSR) are commonly used for detecting ROS by flow cytometry; however, these probes lack sensitivity to hydrogen peroxide (H2O2), which is particularly damaging to mammalian sperm cells. This study reports the synthesis and use of three aryl boronate probes, peroxyfluor-1 (PF1), carboxyperoxyfluor-1, and a novel probe, 2-(2-ethoxyethoxy)ethoxyperoxyfluor-1 (EEPF1), in human spermatozoa. PF1 and EEPF1 were effective at detecting H2O2 and peroxynitrite (ONOO-) produced by spermatozoa when stimulated with menadione or 4-hydroxynonenal. EEPF1 was more effective at detection of ROS in spermatozoa than DCFH, DHE, or MSR; furthermore it distinguished poorly motile sperm as shown by greater ROS production. EEPF1 should therefore have a significant role in the diagnosis of oxidative stress in male infertility, cryopreservation, age, lifestyle, and exposure to environmental toxicants.

DOI10.1016/j.freeradbiomed.2015.01.015
2015Maiti K, Aitken J, Smith R, 'The Human Placenta at 41 Weeks of Gestation Shows Evidence of Aging With Shortened Telomeres, DNA Oxidation and Changes in IGFR2, Autophagy and the mTOR', REPRODUCTIVE SCIENCES, 22 191A-191A (2015)
Author URL
2015Nixon B, Bromfield EG, Dun MD, Redgrove KA, McLaughlin EA, Aitken RJ, 'The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition.', Asian J Androl, 17 568-573 (2015)
DOI10.4103/1008-682X.151395Author URL
Co-authorsEileen Mclaughlin, Brett Nixon, Matt Dun
2015Aitken JB, Naumovski N, Curry B, Grupen CG, Gibb Z, Aitken RJ, 'Characterization of an L-amino Acid oxidase in equine spermatozoa.', Biol Reprod, 92 125 (2015)
DOI10.1095/biolreprod.114.126052Author URL
2015Aitken RJ, Cummins JM, Nixon B, 'The 12 (th) International Symposium on Spermatology.', Asian J Androl, 17 519-520 (2015)
DOI10.4103/1008-682X.153852Author URL
Co-authorsBrett Nixon
2015Aitken RJ, Baker MA, Nixon B, 'Are sperm capacitation and apoptosis the opposite ends of a continuum driven by oxidative stress?', Asian J Androl, 17 633-639 (2015)
DOI10.4103/1008-682X.153850Author URL
Co-authorsBrett Nixon, Mark Baker
2015Reid AT, Anderson AL, Roman SD, McLaughlin EA, McCluskey A, Robinson PJ, et al., 'Glycogen synthase kinase 3 regulates acrosomal exocytosis in mouse spermatozoa via dynamin phosphorylation.', FASEB J, 29 2872-2882 (2015)
DOI10.1096/fj.14-265553Author URL
Co-authorsEileen Mclaughlin, Brett Nixon, Shaun Roman, Adam Mccluskey
2015Moazamian R, Polhemus A, Connaughton H, Fraser B, Whiting S, Gharagozloo P, Aitken RJ, 'Oxidative stress and human spermatozoa: diagnostic and functional significance of aldehydes generated as a result of lipid peroxidation.', Mol Hum Reprod, 21 502-515 (2015)
DOI10.1093/molehr/gav014Author URL
2015Houston B, Curry B, Aitken RJ, 'Human spermatozoa possess an IL4I1 l-amino acid oxidase with a potential role in sperm function.', Reproduction, 149 587-596 (2015)
DOI10.1530/REP-14-0621Author URL
Co-authorsBen Curry
2014Swegen A, Aitken RJ, 'Prospects for immunocontraception in feral horse population control: exploring novel targets for an equine fertility vaccine.', Reprod Fertil Dev, (2014)
DOI10.1071/RD14280Author URL
2014Gibb Z, Lambourne SR, Aitken RJ, 'The paradoxical relationship between stallion fertility and oxidative stress.', Biology of Reproduction, 91 1-10 (2014) [C1]
DOI10.1095/biolreprod.114.118539
CitationsScopus - 3Web of Science - 2
2014McPherson NO, Fullston T, Aitken RJ, Lane M, 'Paternal obesity, interventions, and mechanistic pathways to impaired health in offspring', Annals of Nutrition and Metabolism, 64 231-238 (2014) [C1]

Background: The global rates of male overweight/obesity are rising, approaching 70% of the total adult population in Western nations. Overweight/obesity increases the risk of chronic diseases; however, there is increasing awareness that male obesity negatively impacts fertility, subsequent pregnancy, and the offspring health burden. Developmental programming is well defined in mothers; however, it is becoming increasingly evident that developmental programming can be paternally initiated and mediated through paternal obesity.

DOI10.1159/000365026
CitationsScopus - 1Web of Science - 1
2014Aitken RJ, Finnie JM, Muscio L, Whiting S, Connaughton HS, Kuczera L, et al., 'Potential importance of transition metals in the induction of DNA damage by sperm preparation media', Human Reproduction, 29 2136-2147 (2014) [C1]

STUDY QUESTION: What are the mechanisms by which the preparation of spermatozoa on discontinuous density gradients leads to an increase in oxidative DNA damage? SUMMARY ANSWER: The colloidal silicon solutions that are commonly used to prepare human spermatozoa for assisted reproduction technology (ART) purposes contain metals in concentrations that promote free radical-mediated DNA damage. WHAT IS KNOWN ALREADY: Sporadic reports have already appeared indicating that the use of colloidal silicon-based discontinuous density gradients for sperm preparation is occasionally associated with the induction of oxidative DNA damage. The cause of this damage is however unknown. STUDY DESIGN, SIZE, DURATION: This study comprised a series of experiments designed to: (i) confirm the induction of oxidativeDNA damage in spermatozoa prepared on commercially available colloidal silicon gradients, (ii) compare the levels of damage observed with alterative sperm preparation techniques including an electrophoretic approach and (iii) determine the cause of the oxidative DNA damage and develop strategies for its prevention. The semen samples employed for this analysis involved a cohort of >50 unselected donors and at least three independent samples were used for each component of the analysis. PARTICIPANTS/MATERIALS, SETTING, METHODS: The setting was a University biomedical science laboratory. The major techniques employed were: (i) flow cytometry to study reactive oxygen species generation, lipid peroxidation and DNA damage, (ii) computeraided sperm analysis to measure spermmovement and (iii) inductively coupled mass spectrometry to determine the elemental composition of sperm preparation media. MAIN RESULTS AND THE ROLE OF CHANCE: Oxidative DNA damage is induced in spermatozoa prepared on PureSperm® discontinuous colloidal silicon gradients (P < 0.001 versus repeated centrifugation) because this medium contains metals, particularly Fe, Al and Cu, which are known to promote free radical generation in the immediate vicinity of DNA. This damage can be significantly accentuated by reducing agents, such as ascorbate (P < 0.001) and inhibited by selective chelation (P < 0.001). This problem is not confined to PureSperm®; analysis of additional commercial sperm preparation media revealed that metal contamination is a relatively constant feature of such products. LIMITATIONS, REASONS FOR CAUTION: While the presence of metals, particularly transition metals, may exacerbate the levels of oxidative DNA damage seen in human spermatozoa, the significance of such damage has not yet been tested in suitably powered clinical trials. WIDER IMPLICATIONS OF THE FINDINGS: The results explain why the preparation of spermatozoa on discontinuous colloidal silicon gradients can result in oxidative DNA damage. The results are of immediate relevance to the development of safe, effective protocols for the preparation of spermatozoa for ART purposes. STUDY FUNDING/COMPETING INTEREST(S): The studywas funded by the Australian Health and Medical ResearchCouncil. One of the authors (R.J.A.) has had a consultantship with a biotechnology company, NuSep, interested in the development of electrophoretic methods of sperm preparation. He has no current financial interest in this area. None of the other authors have a conflict of interest to declare.

DOI10.1093/humrep/deu204
CitationsWeb of Science - 1
Co-authorsGeoffry DeiuliIs, Tony Rothkirch
2014Aitken RJ, Lambourne S, Gibb Z, 'The John Hughes Memorial Lecture: Aspects of Sperm Physiology-Oxidative Stress and the Functionality of Stallion Spermatozoa', JOURNAL OF EQUINE VETERINARY SCIENCE, 34 17-27 (2014) [C1]
DOI10.1016/j.jevs.2013.10.120Author URL
CitationsScopus - 1Web of Science - 1
2014Aitken RJ, Smith TB, Jobling MS, Baker MA, De Iuliis GN, 'Oxidative stress and male reproductive health', Asian Journal of Andrology, 16 31-38 (2014) [C1]

One of the major causes of defective sperm function is oxidative stress, which not only disrupts the integrity of sperm DNA but also limits the fertilizing potential of these cells as a result of collateral damage to proteins and lipids in the sperm plasma membrane. The origins of such oxidative stress appear to involve the sperm mitochondria, which have a tendency to generate high levels of superoxide anion as a prelude to entering the intrinsic apoptotic cascade. Unfortunately, these cells have very little capacity to respond to such an attack because they only possess the first enzyme in the base excision repair (BER) pathway, 8-oxoguanine glycosylase 1 (OGG1). The latter successfully creates an abasic site, but the spermatozoa cannot process the oxidative lesion further because they lack the downstream proteins (APE1, XRCC1) needed to complete the repair process. It is the responsibility of the oocyte to continue the BER pathway prior to initiation of S-phase of the first mitotic division. If a mistake is made by the oocyte at this stage of development, a mutation will be created that will be represented in every cell in the body. Such mechanisms may explain the increase in childhood cancers and other diseases observed in the offspring of males who have suffered oxidative stress in their germ line as a consequence of age, environmental or lifestyle factors. The high prevalence of oxidative DNA damage in the spermatozoa of male infertility patients may have implications for the health of children conceivedin vitro and serves as a driver for current research into the origins of free radical generation in the germ line. © 2014 AJA, SIMM & SJTU. All rights reserved.

DOI10.4103/1008-682X.122203
CitationsScopus - 19Web of Science - 19
Co-authorsMark Baker, Geoffry DeiuliIs
2014Aitken RJ, 'Age, the environment and our reproductive future: bonking baby boomers and the future of sex', REPRODUCTION, 147 S1-S11 (2014) [C1]
DOI10.1530/REP-13-0399Author URL
CitationsWeb of Science - 4
2014Aitken RJ, 'Age, the environment and our reproductive future: bonking baby boomers and the future of sex', REPRODUCTION, 147 S1-S11 (2014) [C1]
DOI10.1530/REP-13-0399Author URL
CitationsWeb of Science - 4
2014Bromfield EG, Aitken RJ, Gibb Z, Lambourne SR, Nixon B, 'Capacitation in the presence of methyl-beta-cyclodextrin results in enhanced zona pellucida-binding ability of stallion spermatozoa', REPRODUCTION, 147 153-166 (2014) [C1]
DOI10.1530/REP-13-0393Author URL
CitationsScopus - 2Web of Science - 2
Co-authorsBrett Nixon
2014Gibb Z, Lambourne SR, Aitken RJ, 'The paradoxical relationship between stallion fertility and oxidative stress.', Biol Reprod, 91 77 (2014)
DOI10.1095/biolreprod.114.118539Author URL
2013Aitken RJ, 'Human spermatozoa: Revelations on the road to conception', F1000Prime Reports, 5 (2013) [C2]

Human spermatozoa are highly complex specialized cells designed to survive a long and perilous journey from the site of insemination to the upper reaches of the female reproductive tract where fertilization occurs. During this journey, these cells have to run the gauntlet laid down by the female immune system and time their physiological maturation so that as soon as an egg appears in the Fallopian tube, they are equipped to recognize this cell and participate in a remarkable cascade of cellular interactions culminating in fertilization. Despite their high level of specialization, human spermatozoa are notoriously inadequate and appear to be major contributors to the poor fertility that characterizes our species. Defective spermatozoa are also known to have a major impact on the progress of pregnancy and the health trajectory of the offspring, resulting in paternally mediated increases in miscarriage rate and a range of diseases in the progeny, including dominant genetic diseases and cancer. The causes of defective sperm function are complex and involve both genetic and environmental impacts, aswell as paternal age.Where genetic factors are involved, there is a concern that the widespread use of assisted conception technologies will serve to enhance the retention of poor fertility genes in the population such that the more we use assisted reproductive technologies in one generation the more we shall need them in the next. These observations may have important implications for the health and well-being of children and for the provision of reproductive healthcare services for future generations. © 2013 Faculty of 1000 Ltd.

DOI10.12703/P5-39
CitationsScopus - 1
2013Lord T, Nixon B, Jones KT, Aitken RJ, 'Melatonin Prevents Postovulatory Oocyte Aging in the Mouse and Extends the Window for Optimal Fertilization In Vitro', Biology of Reproduction, 88 1-9 (2013) [C1]
DOI10.1095/biolreprod.112.106450Author URL
CitationsScopus - 8Web of Science - 6
Co-authorsBrett Nixon, Keith Jones
2013Smith TB, Dun MD, Smith ND, Curry BJ, Connaughton HS, Aitken RJ, 'The presence of a truncated base excision repair pathway in human spermatozoa that is mediated by OGG1', JOURNAL OF CELL SCIENCE, 126 1488-1497 (2013) [C1]
DOI10.1242/jcs.121657Author URL
CitationsScopus - 14Web of Science - 11
Co-authorsMatt Dun, Ben Curry
2013Smith R, Maiti K, Aitken RJ, 'Unexplained antepartum stillbirth: A consequence of placental aging?', PLACENTA, 34 310-313 (2013) [C3]
DOI10.1016/j.placenta.2013.01.015Author URL
CitationsScopus - 3Web of Science - 3
Co-authorsRoger Smith
2013Aitken RJ, Baker MA, 'Oxidative stress, spermatozoa and leukocytic infiltration: Relationships forged by the opposing forces of microbial invasion and the search for perfection', Journal of Reproductive Immunology, 100 11-19 (2013) [C1]
DOI10.1016/j.jri.2013.06.005
CitationsScopus - 6Web of Science - 5
Co-authorsMark Baker
2013Aitken RJ, Baker MA, 'Causes and consequences of apoptosis in spermatozoa; contributions to infertility and impacts on development', International Journal of Developmental Biology, 57 265-272 (2013) [C1]

During early development, apoptosis plays a major role in the ontogeny of the germ line as a means of regulating the germ cell:Sertoli cell ratio. In the adult, apoptosis fulfils another function in removing damaged germ cells from the seminiferous epithelium in response to a wide range of physiological and environmental triggers. These include various forms of electromagnetic radiation, chemotherapeutic agents and commonly encountered toxicants such as phthalate es-ters, bisphenol A and cadmium. This form of apoptosis can lead to spermatogenic arrest and is predominantly mediated by the Fas/FasL system. In addition, senescent mature spermatozoa can undergo a truncated form of apoptosis in order to ensure their efficient phagocytosis within the male and female reproductive tracts. This apoptotic cascade appears to be triggered by oxidative stress and lipid peroxidation, which leads to activation of mitochondrial reactive oxygen species (ROS) generation in a self-perpetuating redox cycle. The electrophilic aldehydes generated as a result of lipid peroxidation also lead to a rapid loss of sperm motility followed some hours later by caspase activation and phosphatidylserine exposure on the sperm surface. The nuclear DNA suffers oxidative damage during this process but there is no immediate DNA cleavage by endonucleases as there is in somatic cells. The reasons for this deviation from the normal pattern of apoptosis involve the unusual physical architecture of spermatozoa and the limited capacity these cells possess for base-excision repair. These findings have practical implications for the approaches that might be used to detect and prevent DNA damage in spermatozoa. © 2013 UBC Press.

DOI10.1387/ijdb.130146ja
CitationsScopus - 13Web of Science - 12
Co-authorsMark Baker
2013Barzideh J, Scott RJ, Aitken RJ, 'Analysis of the global methylation status of human spermatozoa and its association with the tendency of these cells to enter apoptosis', ANDROLOGIA, 45 424-429 (2013) [C1]
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CitationsScopus - 5Web of Science - 2
Co-authorsRodney Scott
2013Smith TB, Baker MA, Connaughton HS, Habenicht U, Aitken RJ, 'Functional deletion of Txndc2 and Txndc3 increases the susceptibility of spermatozoa to age-related oxidative stress', Free Radical Biology and Medicine, 65 872-881 (2013) [C1]
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CitationsScopus - 6Web of Science - 4
Co-authorsMark Baker
2013Aitken RJ, 'Falling sperm counts twenty years on: where are we now?', ASIAN JOURNAL OF ANDROLOGY, 15 204-207 (2013) [C3]
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CitationsScopus - 4Web of Science - 2
2013Redgrove KA, Anderson AL, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B, 'Investigation of the mechanisms by which the molecular chaperone HSPA2 regulates the expression of sperm surface receptors involved in human spermoocyte recognition', MOLECULAR HUMAN REPRODUCTION, 19 120-135 (2013) [C1]
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CitationsScopus - 15Web of Science - 15
Co-authorsEileen Mclaughlin, Brett Nixon
2013Aitken RJ, Bronson R, Smith TB, De Iuliis GN, 'The source and significance of DNA damage in human spermatozoa; a commentary on diagnostic strategies and straw man fallacies', Molecular Human Reproduction, 19 475-485 (2013) [C1]
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CitationsScopus - 10Web of Science - 11
Co-authorsGeoffry DeiuliIs
2013Aitken RJ, Nixon B, 'Sperm capacitation: a distant landscape glimpsed but unexplored', Molecular Human Reproduction, 19 785-793 (2013) [C1]
DOI10.1093/molehr/gat067Author URL
CitationsScopus - 10Web of Science - 8
Co-authorsBrett Nixon
2013Smith TB, De Iuliis GN, Lord T, Aitken RJ, 'The senescence-accelerated mouse prone 8 as a model for oxidative stress and impaired DNA repair in the male germ line', Reproduction, 146 253-262 (2013) [C1]
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CitationsScopus - 10Web of Science - 6
Co-authorsGeoffry DeiuliIs
2013Lord T, Aitken RJ, 'Oxidative stress and ageing of the post-ovulatory oocyte', Reproduction, 146 217-227 (2013) [C1]
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CitationsScopus - 7Web of Science - 7
2013Lewis SEM, Aitken RJ, Conner SJ, De Iuliis G, Evenson DP, Henkel R, et al., 'The impact of sperm DNA damage in assisted conception and beyond: Recent advances in diagnosis and treatment', Reproductive BioMedicine Online, 27 325-337 (2013) [C1]
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CitationsScopus - 14Web of Science - 12
Co-authorsGeoffry DeiuliIs
2013Aitken RJ, 'Can spermatozoa respond to changes in their redox status with the selective activation of gene transcription?', Antioxidants and Redox Signaling, 18 184-185 (2013) [C3]
DOI10.1089/ars.2012.4715
CitationsScopus - 1Web of Science - 1
2013Baker MA, Weinberg AS, Hetherington L, Velkov T, Aitken RJ, 'Post-ejaculatory changes in the metabolic status of rat spermatozoa as measured by GC-MS', Metabolomics, 9 708-721 (2013) [C1]
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Co-authorsMark Baker
2013Baker MA, Naumovski N, Hetherington L, Weinberg A, Velkov T, Aitken RJ, 'Head and flagella subcompartmental proteomic analysis of human spermatozoa', Proteomics, 13 61-74 (2013) [C1]
DOI10.1002/pmic.201200350Author URL
CitationsScopus - 29Web of Science - 29
Co-authorsMark Baker
2013Jrad-Lamine A, Henry-Berger J, Damon-Soubeyrand C, Saez F, Kocer A, Janny L, et al., 'Indoleamine 2,3-Dioxygenase 1 (Ido1) Is Involved in the Control of Mouse Caput Epididymis Immune Environment', PLOS ONE, 8 (2013) [C1]
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CitationsScopus - 2Web of Science - 1
2013Aitken RJ, Smith TB, Lord T, Kuczera L, Koppers AJ, Naumovski N, et al., 'On methods for the detection of reactive oxygen species generation by human spermatozoa: analysis of the cellular responses to catechol oestrogen, lipid aldehyde, menadione and arachidonic acid', Andrology, 1 192-205 (2013) [C1]
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CitationsScopus - 11Web of Science - 11
Co-authorsMark Baker, Geoffry DeiuliIs
2012Aitken RJ, Gibb Z, Mitchell LA, Lambourne SR, Connaughton HS, De Iuliis GN, 'Sperm motility is lost in vitro as a consequence of mitochondrial free radical production and the generation of electrophilic aldehydes but can be significantly rescued by the presence of nucleophilic thiols', Biology of Reproduction, 87 1-11 (2012) [C1]
CitationsScopus - 22Web of Science - 14
Co-authorsGeoffry DeiuliIs
2012Aitken RJ, Whiting SJ, De Iuliis GN, McClymont SL, Mitchell LA, Baker MA, 'Electrophilic aldehydes generated by sperm metabolism activate mitochondrial reactive oxygen species generation and apoptosis by targeting succinate dehydrogenase', Journal of Biological Chemistry, 287 33048-33060 (2012) [C1]
DOI10.1074/jbc.M112.366690
CitationsScopus - 29Web of Science - 26
Co-authorsMark Baker, Geoffry DeiuliIs
2012Reid AT, Lord T, Stanger SJ, Roman SD, McCluskey A, Robinson PJ, et al., 'Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa', Journal of Biological Chemistry, 287 37659-37672 (2012) [C1]
CitationsScopus - 10Web of Science - 9
Co-authorsShaun Roman, Adam Mccluskey, Brett Nixon
2012Dun MD, Anderson AL, Bromfield EG, Asquith KL, Emmett BJ, McLaughlin EA, et al., 'Investigation of the expression and functional significance of the novel mouse sperm protein, a disintegrin and metalloprotease with thrombospondin type 1 motifs number 10 (ADAMTS10)', International Journal of Andrology, 35 572-589 (2012) [C1]
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CitationsScopus - 6Web of Science - 5
Co-authorsMatt Dun, Eileen Mclaughlin, Brett Nixon
2012Jones KT, Robertson SA, Aitken RJ, 'Reactive oxygen species and sperm function-in sickness and in health', Journal of Andrology, 33 1096-1106 (2012) [C1]
CitationsScopus - 35Web of Science - 29
Co-authorsKeith Jones
2012Aitken RJ, De Iuliis GN, Gibb Z, Baker MA, 'The Simmet lecture: New horizons on an old landscape - oxidative stress, DNA damage and apoptosis in the male germ line', Reproduction in Domestic Animals, 47 7-14 (2012) [C2]
CitationsScopus - 10Web of Science - 10
Co-authorsGeoffry DeiuliIs, Mark Baker
2012Dun MD, Aitken RJ, Nixon B, 'The role of molecular chaperones in spermatogenesis and the post-testicular maturation of mammalian spermatozoa', Human Reproduction Update, 18 420-435 (2012) [C1]
DOI10.1093/humupd/dms009
CitationsScopus - 10Web of Science - 10
Co-authorsMatt Dun, Brett Nixon
2012Baker MA, Hetherington L, Weinberg AS, Naumovski N, Velkov T, Pelzing M, et al., 'Analysis of phosphopeptide changes as spermatozoa acquire functional competence in the epididymis demonstrates changes in the post-translational modification of Izumo1', Journal of Proteome Research, 11 5252-5264 (2012) [C1]
DOI10.1021/pr300468m
CitationsScopus - 5Web of Science - 5
Co-authorsMark Baker
2012Lo JCY, Jamsai D, O'Connor AE, Borg C, Clark BJ, Whisstock JC, et al., 'RAB-Like 2 has an essential role in male fertility, sperm intra-flagellar transport, and tail assembly', PLOS Genetics, 8 e1002969 (2012) [C1]
CitationsScopus - 14Web of Science - 15
2012Redgrove KA, Nixon B, Baker MA, Hetherington L, Baker G, Liu D-Y, Aitken RJ, 'The molecular chaperone HSPA2 plays a key role in regulating the expression of sperm surface receptors that mediate sperm-egg recognition', Plos One, 7 1-16 (2012) [C1]
CitationsScopus - 20Web of Science - 19
Co-authorsBrett Nixon, Mark Baker
2012Baker MA, Nixon B, Naumovski N, Aitken RJ, 'Proteomic insights into the maturation and capacitation of mammalian spermatozoa', Systems Biology in Reproductive Medicine, 58 211-217 (2012) [C1]
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CitationsScopus - 22Web of Science - 20
Co-authorsMark Baker, Brett Nixon
2011Aitken RJ, Curry BJ, 'Redox regulation of human sperm function: From the physiological control of sperm capacitation to the etiology of infertility and DNA damage in the germ line', Antioxidants & Redox Signaling, 14 367-381 (2011) [C1]
DOI10.1089/ars.2010.3186
CitationsScopus - 62Web of Science - 58
Co-authorsBen Curry
2011Baker MA, Smith ND, Hetherington L, Pelzing M, Condina MR, Aitken RJ, 'Use of titanium dioxide to find phosphopeptide and total protein changes during epididymal sperm maturation', Journal of Proteome Research, 10 1004-1017 (2011) [C1]
DOI10.1021/pr1007224
CitationsScopus - 21Web of Science - 17
Co-authorsMark Baker
2011Aitken RJ, 'The capacitation-apoptosis highway: Oxysterols and mammalian sperm function', Biology of Reproduction, 85 9-12 (2011) [C3]
DOI10.1095/biolreprod.111.092528
CitationsScopus - 18Web of Science - 18
2011Redgrove KA, Anderson AL, Dun MD, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B, 'Involvement of multimeric protein complexes in mediating the capacitation-dependent binding of human spermatozoa to homologous zonae pellucidae', Developmental Biology, 356 460-474 (2011) [C1]
DOI10.1016/j.ydbio.2011.05.674
CitationsScopus - 20Web of Science - 22
Co-authorsMatt Dun, Eileen Mclaughlin, Brett Nixon
2011Jrad-Lamine A, Henry-Berger J, Gourbeyre P, Damon-Soubeyrand C, Lenoir A, Combaret L, et al., 'Deficient tryptophan catabolism along the kynurenine pathway reveals that the epididymis is in a unique tolerogenic state', Journal of Biological Chemistry, 286 8030-8042 (2011) [C1]
DOI10.1074/jbc.M110.172114
CitationsScopus - 15Web of Science - 16
2011Dun MD, Smith ND, Baker MA, Lin M, Aitken RJ, Nixon B, 'The chaperonin containing TCP1 complex (CCT/TRiC) is involved in mediating sperm-oocyte interaction', Journal of Biological Chemistry, 286 36875-36887 (2011) [C1]
DOI10.1074/jbc.m110.188888
CitationsScopus - 19Web of Science - 17
Co-authorsBrett Nixon, Mark Baker, Minjie Lin, Matt Dun
2011Nixon B, Mitchell LA, Anderson AL, McLaughlin EA, O'Bryan MK, Aitken RJ, 'Proteomic and functional analysis of human sperm detergent resistant membranes', Journal of Cellular Physiology, 226 2651-2665 (2011) [C1]
DOI10.1002/jcp.22615
CitationsScopus - 31Web of Science - 28
Co-authorsEileen Mclaughlin, Brett Nixon
2011Ainsworth CJ, Nixon B, Aitken RJ, 'The electrophoretic separation of spermatozoa: An analysis of genotype, surface carbohydrate composition and potential for capacitation', International Journal of Andrology, 34 e422-e434 (2011) [C1]
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CitationsScopus - 9Web of Science - 3
Co-authorsBrett Nixon
2011Aitken RJ, Carey AJ, Beagley KW, 'Dual purpose contraceptives: targeting fertility and sexually transmitted disease', Journal of Reproductive Immunology, 88 228-232 (2011) [C1]
DOI10.1016/j.jri.2010.12.001
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2011Koppers AJ, Mitchell LA, Wang JP, Lin M, Aitken RJ, 'Phosphoinositide 3-kinase signalling pathway involvement in a truncated apoptotic cascade associated with motility loss and oxidative DNA damage in human spermatozoa', Biochemical Journal, 436 687-698 (2011) [C1]
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Co-authorsMinjie Lin
2011Aitken RJ, Mitchell L, De Iuliis GN, 'Reply: M540 bodies interfere with TUNEL analyses in human semen samples', HUMAN REPRODUCTION, 26 729-730 (2011) [C3]
DOI10.1093/humrep/deq371Author URL
Co-authorsGeoffry DeiuliIs
2011Aitken RJ, Hanson AR, Kuczera LH, 'Electrophoretic sperm isolation: Optimization of electrophoresis conditions and impact on oxidative stress', Human Reproduction, 26 1955-1964 (2011) [C1]
DOI10.1093/humrep/der162
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2011Gharagozloo P, Aitken RJ, 'The role of sperm oxidative stress in male infertility and the significance of oral antioxidant therapy', Human Reproduction, 26 1628-1640 (2011) [C1]
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2011McLaughlin EA, Aitken RJ, 'Is there a role for immunocontraception?', Molecular and Cellular Endocrinology, 335 78-88 (2011) [C1]
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Co-authorsEileen Mclaughlin
2011Aitken RJ, Henkel R, 'Special Edition of the Asian Journal of Andrology on The Cell Biology and Genetics of Spermatozoa', Asian Journal of Andrology, 13 3-5 (2011) [C6]
2011Aitken RJ, Koppers AJ, 'Apoptosis and DNA damage in human spermatozoa', Asian Journal of Andrology, 13 36-42 (2011) [C1]
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2011Aitken RJ, Henkel RR, 'Sperm cell biology: current perspectives and future prospects', Asian Journal of Andrology, 13 3-5 (2011) [C3]
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2011Gattellari M, Goumas C, Aitken RJ, Worthington JM, 'Outcomes for patients with ischaemic stroke and atrial fibrillation: The PRISM Study (A Program of Research Informing Stroke Management)', Cerebrovascular Diseases, 32 370-382 (2011) [C1]
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2011Aitken RJ, Baker MA, 'Cell biology of human spermatozoa: Lessons from the Proteome', Australian Biochemist, 42 12-15 (2011) [C3]
Co-authorsMark Baker
2011Aitken RJ, Findlay JK, Hutt KJ, Kerr JB, 'Apoptosis in the germ line', Reproduction, 141 139-150 (2011) [C1]
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2011Aitken RJ, Henkel R, 'Special Edition of the Asian Journal of Andrology on The Cell Biology and Genetics of Spermatozoa', Asian Journal of Andrology, 13 3-5 (2011) [C6]
2010Baker MA, Smith ND, Hetherington L, Taubman K, Graham ME, Robinson PJ, Aitken RJ, 'Label-free quantitation of phosphopeptide changes during rat sperm capacitation', Journal of Proteome Research, 9 718-729 (2010) [C1]
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Co-authorsMark Baker
2010Baker MA, Reeves GM, Hetherington L, Aitken RJ, 'Analysis of proteomic changes associated with sperm capacitation through the combined use of IPG-strip pre-fractionation followed by RP chromatography LC-MS/MS analysis', Proteomics, 10 482-495 (2010) [C1]
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Co-authorsMark Baker
2010Shokri S, Aitken RJ, Abdolvahhabi M, Abolhasani F, Ghasemi FM, Kashani I, et al., 'Exercise and supraphysiological dose of nandrolone deconoate increase apoptosis in spermatogenic cells', Basic & Clinical Pharmacology & Toxicology, 106 324-330 (2010) [C1]
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2010Pujianto DA, Curry BJ, Aitken RJ, 'Prolactin exerts a prosurvival effect on human spermatozoa via mechanisms that involve the stimulation of Akt phosphorylation and suppression of caspase activation and capacitation', Endocrinology, 151 1269-1279 (2010) [C1]
DOI10.1210/en.2009-0964
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Co-authorsBen Curry
2010Naraghi MA, Abolhasani F, Kashani I, Anarkooli IJ, Hemadi M, Azami A, et al., 'The effects of swimming exercise and supraphysiological doses of nandrolone decanoate on the testis in adult male rats: A transmission electron microscope study', Folia Morphologica, 69 138-146 (2010) [C1]
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2010Mitchell LA, De Iuliis GN, Aitken RJ, 'The TUNEL assay consistently underestimates DNA damage in human spermatozoa and is influenced by DNA compaction and cell vitality: Development of an improved methodology', International Journal of Andrology, 34 2-13 (2010) [C1]
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Co-authorsGeoffry DeiuliIs
2010Barratt CLR, Aitken RJ, Bjorndahl L, Carrell DT, De Boer P, Kvist U, et al., 'Sperm DNA: Organization, protection and vulnerability: From basic science to clinical applications - A position report', Human Reproduction, 25 824-838 (2010) [C1]
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2010Aitken RJ, De Iuliis GN, Finnie JM, Hedges A, McLachlan RI, 'Analysis of the relationships between oxidative stress, DNA damage and sperm vitality in a patient population: Development of diagnostic criteria', Human Reproduction, 25 2415-2426 (2010) [C1]
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Co-authorsGeoffry DeiuliIs
2010Koppers AJ, Garg ML, Aitken RJ, 'Stimulation of mitochondrial reactive oxygen species production by unesterified, unsaturated fatty acids in defective human spermatozoa', Free Radical Biology and Medicine, 48 112-119 (2010) [C1]
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Co-authorsManohar Garg
2010Aitken RJ, 'Whither must spermatozoa wander? The future of laboratory seminology', Asian Journal of Andrology, 12 99-103 (2010) [C3]
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2010Reid AT, Redgrove KA, Aitken RJ, Nixon B, 'Cellular mechanisms regulating sperm-zona pellucida interaction', Asian Journal of Andrology, 13 88-96 (2010) [C1]
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Co-authorsBrett Nixon
2010Nixon B, Bielanowicz AJ, Anderson AL, Walsh AK, Hall TE, McCloghry AK, Aitken RJ, 'Elucidation of the signaling pathways that underpin capacitation-associated surface phosphotyrosine expression in mouse spermatozoa', Journal of Cellular Physiology, 224 71-83 (2010) [C1]
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Co-authorsBrett Nixon
2010Aitken RJ, De Iuliis GN, 'On the possible origins of DNA damage in human spermatozoa', Molecular Human Reproduction, 16 3-13 (2010) [C1]
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Co-authorsGeoffry DeiuliIs
2009Baker MA, Aitken RJ, 'Proteomic insights into spermatozoa: Critiques, comments and concerns', Expert Review of Proteomics, 6 691-705 (2009) [C1]
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Co-authorsMark Baker
2009Ewen KA, Baker MA, Wilhelm D, Aitken RJ, Koopman P, 'Global survey of protein expression during gonadal sex determination in mice', Molecular & Cellular Proteomics, 8 2624-2641 (2009) [C1]
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CitationsScopus - 8Web of Science - 7
Co-authorsMark Baker
2009De Iuliis GN, Newey RJ, King BV, Aitken RJ, 'Mobile phone radiation induces reactive oxygen species production and DNA damage in human spermatozoa in vitro', PLoS ONE, 4 e6446 (2009) [C1]
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Co-authorsGeoffry DeiuliIs, Bruce King
2009Nixon B, Aitken RJ, 'Proteomics of human spermatozoa 3-12 (2009)
DOI10.1007/978-3-642-01379-9
Co-authorsBrett Nixon
2009De Iuliis GN, Thomson LK, Mitchell LA, Read JM, Koppers AJ, Hedges A, et al., 'DNA damage in human spermatozoa is highly correlated with the efficiency of chromatin remodeling and the formation of 8-hydroxy-2'-deoxyguanosine, a marker of oxidative stress', Biology of Reproduction, 81 517-524 (2009) [C1]
DOI10.1095/biolreprod.109.076836
CitationsScopus - 116Web of Science - 110
Co-authorsBrett Nixon, Geoffry DeiuliIs
2009Baker MA, Hetherington L, Curry BJ, Aitken RJ, 'Phosphorylation and consequent stimulation of the tyrosine kinase c-Abl by PKA in mouse spermatozoa: Its implications during capacitation', Developmental Biology, 333 57-66 (2009) [C1]
DOI10.1016/j.ydbio.2009.06.022
CitationsScopus - 25Web of Science - 24
Co-authorsBen Curry, Mark Baker
2009Nixon B, Bielanowicz AJ, McLaughlin EA, Tanphaichitr N, Ensslin MA, Aitken RJ, 'Composition and significance of detergent resistant membranes in mouse spermatozoa', Journal of Cellular Physiology, 218 122-134 (2009) [C1]
DOI10.1002/jcp.21575
CitationsScopus - 60Web of Science - 54
Co-authorsBrett Nixon, Eileen Mclaughlin
2009Aitken RJ, 'Gpx5 protects the family jewels', Journal of Clinical Investigation, 119 1849-1851 (2009) [C1]
DOI10.1172/jci39688
CitationsScopus - 10Web of Science - 9
2009Bennetts LE, De Iuliis GN, Nixon B, Kime M, Zelski K, McVicar CM, et al., 'Impact of estrogenic compounds on DNA integrity in human spermatozoa: Evidence for cross-linking and redox cycling activities', Journal of Urology, 181 914-915 (2009) [C3]
DOI10.1016/j.mrfmmm.2008.02.002
CitationsScopus - 44
Co-authorsBrett Nixon, Geoffry DeiuliIs
2009Hughes LM, Griffith R, Carey A, Butler TA, Donne SW, Beagley KW, Aitken RJ, 'The spermostatic and microbicidal actions of quinones and maleimides: Toward a dual-purpose contraceptive agent', Molecular Pharmacology, 76 113-124 (2009) [C1]
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CitationsScopus - 15Web of Science - 16
Co-authorsScott Donne
2009Aitken RJ, De Iuliis GN, McLachlan RI, 'Biological and clinical significance of DNA damage in the male germ line', International Journal of Andrology, 32 46-56 (2009) [C1]
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CitationsScopus - 135Web of Science - 122
Co-authorsGeoffry DeiuliIs
2009Nixon B, Aitken RJ, 'The biological significance of detergent-resistant membranes in spermatozoa', Journal of Reproductive Immunology, 83 8-13 (2009) [C1]
DOI10.1016/j.jri.2009.06.258
CitationsScopus - 24Web of Science - 21
Co-authorsBrett Nixon
2009Thomson LK, Fleming SD, Aitken RJ, De Iuliis GN, Zieschang JA, Clark AM, 'Cryopreservation-induced human sperm DNA damage is predominantly mediated by oxidative stress rather than apoptosis', Human Reproduction, 24 2061-2070 (2009) [C1]
DOI10.1093/humrep/dep214
CitationsScopus - 94Web of Science - 98
Co-authorsGeoffry DeiuliIs
2008Mitchell LA, Nixon B, Baker MA, Aitken RJ, 'Investigation of the role of SRC in capacitation-associated tyrosine phosphorylation of human spermatozoa', Molecular Human Reproduction, 14 235-243 (2008) [C1]
DOI10.1093/molehr/gan007
CitationsScopus - 46Web of Science - 44
Co-authorsBrett Nixon, Mark Baker
2008Bennetts LE, De Iuliis GN, Nixon B, Kime M, Nixon K, McVicar CM, et al., 'Impact of estrogenic compounds on DNA integrity in human spermatozoa: Evidence for cross-linking and redox cycling activities', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 641 1-11 (2008) [C1]
DOI10.1016/j.mrfmmm.2008.02.002
CitationsWeb of Science - 42
Co-authorsGeoffry DeiuliIs, Brett Nixon
2008Baker MA, Hetherington L, Reeves GM, Muller J, Aitken RJ, 'The rat sperm proteome characterized via IPG strip prefractionation and LC-MS/MS identification', Proteomics, 8 2312-2321 (2008) [C1]
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CitationsScopus - 88Web of Science - 64
Co-authorsMark Baker
2008Baker MA, Hetherington L, Reeves GM, Aitken RJ, 'The mouse sperm proteome characterized via IPG strip prefractionation and LC-MS/MS identification', Proteomics, 8 1720-1730 (2008) [C1]
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CitationsScopus - 10Web of Science - 76
Co-authorsMark Baker
2008Aitken RJ, 'Just how safe is assisted reproductive technology for treating, male factor infertility?', Expert Review of Obstetrics and Gynecology, 3 267-271 (2008) [C1]
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2008Aitken RJ, Roman SD, 'Antioxidant systems and oxidative stress in the testes (Reprinted from Molecular Mechanisms in Spermatogenesis, 2007)', OXIDATIVE MEDICINE AND CELLULAR LONGEVITY, 1 15-24 (2008) [C3]
Author URL
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Co-authorsShaun Roman
2008Walsh AK, Whelan D, Bielanowicz AJ, Skinner BL, Aitken RJ, O'Bryan MK, Nixon B, 'Identification of the molecular chaperone, heat shock protein 1 (chaperonin 10), in the reproductive tract and in capacitating spermatozoa in the male mouse', Biology of Reproduction, 78 983-993 (2008) [C1]
DOI10.1095/biolreprod.107.066860
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Co-authorsBrett Nixon
2008Aitken RJ, Hughes LM, Griffith R, Baker MA, 'Bridging the gap between male and female fertility control; contraception-on-demand', Contraception, 78 S28-S35 (2008) [C1]
DOI10.1016/j.contraception.2008.03.020
CitationsScopus - 8Web of Science - 4
Co-authorsMark Baker
2008McLachlan RI, Aitken RJ, Cram D, Krausz C, O'Bryan M, 'Need for standardization and confirmation of STS deletions on the Y chromosome', Fertility and Sterility, 90 463-464 (2008) [C3]
DOI10.1016/j.fertnstert.2008.05.083
CitationsScopus - 1Web of Science - 2
2008Koppers AJ, De Iuliis GN, Read JM, McLaughlin EA, Aitken RJ, 'Significance of mitochondrial reactive oxygen species in the generation of oxidative stress in spermatozoa', Journal of Clinical Endocrinology & Metabolism, 93 3199-3207 (2008) [C1]
DOI10.1210/jc.2007-2616
CitationsScopus - 143Web of Science - 146
Co-authorsEileen Mclaughlin, Geoffry DeiuliIs
2008Aitken RJ, Baker MA, Doncel GF, Matzuk MM, Mauck CK, Harper MJK, 'As the world grows: Contraception in the 21st century', Journal of Clinical Investigation, 118 1330-1343 (2008) [C1]
DOI10.1172/jci33873
CitationsScopus - 40Web of Science - 28
Co-authorsMark Baker
2008Aitken RJ, Baker MA, 'The role of proteomics in understanding sperm cell biology', International Journal of Andrology, 31 295-302 (2008) [C1]
DOI10.1111/j.1365-2605.2007.00851.x
CitationsScopus - 61Web of Science - 59
Co-authorsMark Baker
2008Fleming SD, Ilad RS, Griffin AMG, Wu Y, Ong KJ, Smith HC, Aitken RJ, 'Prospective controlled trial of an electrophoretic method of sperm preparation for assisted reproduction: Comparison with density gradient centrifugation', Human Reproduction, 23 2646-2651 (2008) [C1]
DOI10.1093/humrep/den330
CitationsScopus - 27Web of Science - 21
2007Hughes LM, Griffith R, Aitken RJ, 'The search for a topical dual action spermicide/microbicide', Current Medicinal Chemistry, 14 775-786 (2007) [C1]
DOI10.2174/092986707780090972
CitationsScopus - 24Web of Science - 19
2007Aitken RJ, Nixon B, Lin M, Koppers AJ, Lee YH, Baker MA, 'Proteomic changes in mammalian spermatozoa during epididymal maturation', Asian Journal of Andrology, 9 554-564 (2007) [C1]
DOI10.1111/j.1745-7262.2007.00280.x
CitationsScopus - 70Web of Science - 62
Co-authorsBrett Nixon, Minjie Lin, Mark Baker
2007Mitchell LA, Nixon B, Aitken RJ, 'Analysis of chaperone proteins associated with human spermatozoa during capacitation', Molecular Human Reproduction, 13 605-613 (2007) [C1]
DOI10.1093/molehr/gam043
CitationsScopus - 38Web of Science - 34
Co-authorsBrett Nixon
2007Aitken RJ, Wingate JK, De Iuliis GN, McLaughlin EA, 'Analysis of lipid peroxidation in human spermatozoa using BODIPY C11', Molecular Human Reproduction, 13 203-211 (2007) [C1]
DOI10.1093/molehr/gal119
CitationsScopus - 59Web of Science - 62
Co-authorsGeoffry DeiuliIs, Eileen Mclaughlin
2007Nixon B, Aitken RJ, McLaughlin EA, 'New insights into the molecular mechanisms of sperm-egg interaction', Cellular and Molecular Life Sciences, 64 1805-1823 (2007) [C1]
DOI10.1007/s00018-007-6552-x
Co-authorsBrett Nixon, Eileen Mclaughlin
2007Baker MA, Reeves GE, Hetherington L, Muller J, Baur I, Aitken RJ, 'Identification of gene products present in Triton X-100 soluble and insoluble fractions of human spermatozoa lysates using LC-MS/MS analysis', Proteomics Clinical Applications, 1 524-532 (2007) [C1]
DOI10.1002/prca.200601013
CitationsScopus - 98Web of Science - 93
Co-authorsMark Baker
2007Hughes L, Wingate JK, Griffith R, Aitken RJ, 'Modelling and measuring redox cycling and cytotoxicity of quinones', Drug Metabolism Letters, 1 245-253 (2007) [C2]
2007Aitken RJ, De Iuliis GN, 'Value of DNA integrity assays for fertility evaluation', Society for Reproduction and Fertility Supplement, 65 81-92 (2007) [C1]
CitationsScopus - 50
Co-authorsGeoffry DeiuliIs
2007Aitken RJ, McLaughlin EA, 'Molecular mechanisms of sperm capacitation: progesterone-induced secondary calcium oscillations reflect the attainment of a capacitated state', Society of Reproduction and Fertility Supplement, 63 273-293 (2007) [C1]
CitationsScopus - 25
Co-authorsEileen Mclaughlin
2007Aitken RJ, De Iuliis GN, 'Origins and consequences of DNA damage in male germ cells', Reproductive Biomedicine Online, 14 727-733 (2007) [C1]
DOI10.1016/S1472-6483(10)60676-1
CitationsScopus - 164Web of Science - 163
Co-authorsGeoffry DeiuliIs
2007Gibbs GM, Bianco DM, Jamsai D, Herlihy A, Ristevski S, Aitken RJ, et al., 'Cysteine-rich secretory protein 2 binds to mitogen-activated protein kinase kinase kinase 11 in mouse sperm', Biology of Reproduction, 77 108-114 (2007) [C1]
DOI10.1095/biolreprod.106.057166
CitationsScopus - 19Web of Science - 19
2007Wathes DC, Abayasekara DRE, Aitken RJ, 'Polyunsaturated fatty acids in male and female reproduction', Biology of Reproduction, 77 190-201 (2007) [C1]
DOI10.1095/biolreprod.107.060558
CitationsScopus - 199Web of Science - 172
2007Ainsworth CJ, Nixon B, Jansen RPS, Aitken RJ, 'First recorded pregnancy and normal birth after ICSI using electrophoretically isolated spermatozoa', Human Reproduction, 22 197-200 (2007) [C1]
DOI10.1093/humrep/del351
CitationsScopus - 39Web of Science - 35
Co-authorsBrett Nixon
2006Baker MA, Hetherington L, Aitken RJ, 'Identification of SRC as a key PKA-stimulated tyrosine kinase involved in the capacitation-associated hyperactivation of murine spermatozoa', Journal of Cell Science, 119 3182-3192 (2006) [C1]
DOI10.1242/jcs.03055
CitationsScopus - 99Web of Science - 98
Co-authorsMark Baker
2006De Iuliis GN, Wingate JK, Koppers AJ, McLaughlin EA, Aitken RJ, 'Definitive evidence for the nonmitochondrial production of superoxide anion by human spermatozoa', Journal of Clinical Endocrinology and Metabolism, 91 1968-1975 (2006) [C1]
DOI10.1210/jc.2005-2711
CitationsScopus - 61Web of Science - 48
Co-authorsEileen Mclaughlin, Geoffry DeiuliIs
2006Aitken RJ, Wingate JK, De Iuliis GN, Koppers AJ, McLaughlin EA, 'Cis-unsaturated Fatty acids stimulate reactive oxygen species generation and lipid peroxidation in human spermatozoa', Journal of Clinical Endocrinology and Metabolism, 91 4154-4163 (2006) [C1]
DOI10.1210/jc.2006-1309
CitationsScopus - 75Web of Science - 72
Co-authorsGeoffry DeiuliIs, Eileen Mclaughlin
2006Holt JE, Roman SD, Aitken RJ, McLaughlin EA, 'Identification and characterization of a novel Mt-retrotransposon highly represented in the female mouse germline', Genomics, 87 490-499 (2006) [C1]
DOI10.1016/j.ygeno.2005.08.015
CitationsScopus - 3Web of Science - 3
Co-authorsShaun Roman, Eileen Mclaughlin, Janet Holt
2006Curry BJ, Holt JE, McLaughlin EA, Aitken RJ, 'Characterization of structure and expression of the Dzip1 gene in the rat and mouse', Genomics, 87 275-285 (2006) [C1]
DOI10.1016/j.ygeno.2005.10.007
CitationsScopus - 2Web of Science - 2
Co-authorsEileen Mclaughlin, Ben Curry, Janet Holt
2006Aitken RJ, Skakkebaek NE, Roman SD, 'Male reproductive health and the environment (Editorial)', Medical Journal of Australia, 185 414-415 (2006) [C3]
CitationsScopus - 14Web of Science - 14
Co-authorsShaun Roman
2006Holt JE, Jackson A, Roman SD, Aitken RJ, Koopman PA, McLaughlin EA, 'CXCR4/SDF1 interaction inhibits the primordial to primary follicle transition in the neonatal mouse ovary', Developmental Biology, 293 449-460 (2006) [C1]
DOI10.1016/j.ydbio.2006.02.012
CitationsScopus - 47Web of Science - 44
Co-authorsShaun Roman, Janet Holt, Eileen Mclaughlin
2006Habenicht UF, Harper M, Wang YF, de Kretser D, Aitken RJ, 'Round table discussion on "Public health: contribution of family planning towards public health"', MOLECULAR AND CELLULAR ENDOCRINOLOGY, 250 212-213 (2006)
DOI10.1016/j.mce.2005.12.048Author URL
2006Aitken RJ, Baker MA, 'Oxidative stress, sperm survival and fertility control', Molecular and Cellular Endocrinology, 250 66-69 (2006) [C1]
DOI10.1016/j.mce.2005.12.026
CitationsScopus - 177Web of Science - 158
Co-authorsMark Baker
2006Habenicht UF, Harper M, Wang YF, De Kretser D, Aitken RJ, 'Public health: contribution of family planning towards public health (Round table discussion)', Molecular and Cellular Endocrinology, 250 212-213 (2006) [C2]
2006Gasanov U, Koina CA, Beagley KW, Aitken RJ, Hansbro PM, 'Identification of the insulin-like growth factor II receptor as a novel receptor for binding and invasion by Listeria monocytogenes', Infection and Immunity, 74 566-577 (2006) [C1]
DOI10.1128/IAI.74.1.566-577.2006
CitationsScopus - 6Web of Science - 5
Co-authorsPhilip Hansbro
2006Aitken RJ, 'Sperm function tests and fertility', International Journal of Andrology, 29 69-74 (2006) [C1]
DOI10.1111/j.1365-2605.2005.00630.x
CitationsScopus - 117Web of Science - 100
2006Nixon B, Macintyre DA, Mitchell LA, Gibbs GM, O'Bryan M, Aitken RJ, 'The identification of mouse sperm-surface-associated proteins and characterization of their ability to act as decapacitation factors', Biology of Reproduction, 74 275-287 (2006) [C1]
DOI10.1095/biolreprod.105.044644
CitationsScopus - 69Web of Science - 70
Co-authorsBrett Nixon
2006Lin M, Lee YH, Xu W, Baker MA, Aitken RJ, 'Ontogeny of tyrosine phosphorylation-signaling pathways during spermatogenesis and epididymal maturation in the mouse', Biology of Reproduction, 75 588-597 (2006) [C1]
DOI10.1095/biolreprod.106.052712
CitationsScopus - 16Web of Science - 15
Co-authorsMinjie Lin, Mark Baker
2005Nixon B, Paul JW, Spiller CM, Attwell-Heap AG, Ashman LK, Aitken RJ, 'Evidence for the involvement of PECAM-1 in a receptor mediated signal-transduction pathway regulating capacitation-associated tyrosine phosphorylation in human spermatozoa', Journal of Cell Science, 118 4865-4877 (2005) [C1]
DOI10.1242/jcs.02604
CitationsScopus - 13Web of Science - 13
Co-authorsLeonie Ashman, Brett Nixon
2005Lewis SEM, Aitken RJ, 'DNA damage to spermatozoa has impacts on fertilization and pregnancy', Cell and Tissue Research, 322 33-41 (2005) [C1]
DOI10.1007/s00441-005-1097-5
CitationsScopus - 194Web of Science - 177
2005Nixon B, Asquith KL, Aitken RJ, 'The role of molecular chaperones in mouse sperm-egg interactions', Molecular and Cellular Endocrinology, 240 1-10 (2005) [C1]
DOI10.1016/j.mce.2005.06.004
CitationsScopus - 20Web of Science - 16
Co-authorsBrett Nixon
2005Ewen KA, Wilhelm D, Aitken RJ, Koopman PA, 'Identification and characterisation of proteins influencing mammalian germ cell differentiation', MECHANISMS OF DEVELOPMENT, 122 S119-S119 (2005)
Author URL
2005Roman SD, Baleato RM, Aitken RJ, 'Interaction between BMP4 and retinoid signaling in mouse spermatogenesis', MECHANISMS OF DEVELOPMENT, 122 S126-S126 (2005)
Author URL
Co-authorsShaun Roman
2005Bennetts LE, Aitken RJ, 'A comparative study of oxidative DNA damage in mammalian spermatozoa', Molecular Reproduction and Development, 71 77-87 (2005) [C1]
DOI10.1002/mrd.20285
CitationsScopus - 78Web of Science - 65
2005Aitken RJ, Bennetts LE, Sawyer D, Wiklendt AM, King BV, 'Impact of radio frequency electromagnetic radiation on DNA integrity in the male germline', International Journal of Andrology, 28 171-179 (2005) [C1]
DOI10.1111/j.1365-2605.2005.00531.x
CitationsScopus - 129Web of Science - 101
Co-authorsBruce King
2005Baker MA, Aitken RJ, 'Reactive oxygen species in spermatozoa: methods for monitoring and significance for the origins of genetic disease and infertility', Reproductive Biology and Endocrinology, 3 9 (2005) [C1]
DOI10.1186/1477-7827-3-67
CitationsScopus - 95Web of Science - 82
Co-authorsMark Baker
2005Baker MA, Krutskikh A, Curry BJ, Hetherington L, Aitken RJ, 'Identification of cytochrome-b5 reductase as the enzyme responsible for NADH-dependent lucigenin chemiluminescence in human spermatozoa', Biology of Reproduction, 73 334-342 (2005) [C1]
DOI10.1095/biolreprod.104.037960
CitationsScopus - 25Web of Science - 25
Co-authorsBen Curry, Mark Baker
2005Baker MA, Witherdin RF, Hetherington L, Cunningham KA, Aitken RJ, 'Identification of post-translational modifications that occur during sperm maturation using difference in two-dimensional gel electrophoresis', Proteomics, 5 1003-1012 (2005) [C1]
DOI10.1002/pmic.200401100
CitationsScopus - 71Web of Science - 68
Co-authorsMark Baker
2004Blackmore DG, Baillie LR, Holt JE, Dierkx LM, Aitken RJ, McLaughlin EA, 'Biosynthesis of the Canine Zona Pellucida Requires the Integrated Participation of Both Oocytes and Granulosa Cells', Biology of Reproduction, 71 661-668 (2004) [C1]
DOI10.1095/biolreprod.104.028779
CitationsScopus - 25Web of Science - 24
Co-authorsEileen Mclaughlin, Janet Holt
2004Baker MA, Krutskikh A, Curry BJ, McLaughlin EA, Aitken RJ, 'Identification of Cytochrome P450-Reductase as the Enzyme Responsible for NADPH-Dependent Lucigenin and Tetrazolium Salt Reduction in Rat Epididymal Sperm Preparations', Biology of Reproduction, 71 307-318 (2004) [C1]
DOI10.1095/biolreprod.104.027748
CitationsScopus - 35Web of Science - 34
Co-authorsEileen Mclaughlin, Ben Curry, Mark Baker
2004Ecroyd HW, Asquith KL, Jones RC, Aitken RJ, 'The development of signal transduction pathways during epididymal maturation is calcium dependent', Developmental Biology, 268 53-63 (2004) [C1]
DOI10.1016/j.ydbio.2003.12.015
CitationsScopus - 31Web of Science - 29
2004Baker MA, Hetherington L, Ecroyd HW, Roman SD, Aitken RJ, 'Analysis of the mechanism by which calcium negatively regulates the tyrosine phoshorylation cascade associated with sperm capacitation', Journal of Cell Science, 117 211-222 (2004) [C1]
DOI10.1242/jcs.00842
Co-authorsMark Baker, Shaun Roman
2004Asquith KL, Baleato R, McLaughlin EA, Nixon B, Aitken RJ, 'Tyrosine phosphorylation activates surface chaperones facilitating sperm-zona recognition', Journal of Cell Science, 117 3645-3657 (2004) [C1]
DOI10.1242/jcs.01214
CitationsScopus - 104Web of Science - 94
Co-authorsBrett Nixon, Eileen Mclaughlin
2004Aitken RJ, Koopman P, Lewis SEM, 'Seeds of concern', Nature, 432 48-52 (2004) [C1]
DOI10.1038/432048a
CitationsScopus - 174Web of Science - 157
2004Aitken RJ, Baker MA, O'Bryan M, 'Shedding Light on Chemiluminescence: The Application of Chemiluminescence in Diagnostic Andrology', Journal of Andrology, 25 455-465 (2004) [C1]
CitationsScopus - 31Web of Science - 34
Co-authorsMark Baker
2004Baker MA, Aitken RJ, 'The importance of redox regulated pathways in sperm cell biology', Molecular and Cellular Endocrinology, 216 47-54 (2004) [C1]
DOI10.1016/j.mce.2003.10.068
CitationsScopus - 90Web of Science - 83
Co-authorsMark Baker
2004Vernet P, Aitken RJ, Drevet JR, 'Antioxidant strategies in the epididymis', Molecular and Cellular Endocrinology, 216 31-39 (2004) [C1]
DOI10.1016/j.mce.2003.10.069
CitationsScopus - 159Web of Science - 151
2004Curry BJ, Su H, Law EG, McLaughlin EA, Nixon B, Aitken RJ, 'Identification of RARhoGAP, a novel putative RhoGAP gene expressed in male germ cells', Genomics, 84 406-418 (2004) [C1]
DOI10.1016/j.ygeno.2004.03.004
CitationsScopus - 9Web of Science - 10
Co-authorsBrett Nixon, Eileen Mclaughlin, Ben Curry
2004Curry BJ, Roman SD, Wallace C, Scott RJ, Miriami E, Aitken RJ, 'Identification and characterisation of a novel splice variant of mouse and rat cytochrome b5/cytochrome b5 reductase', Genomics, 83 425-438 (2004) [C1]
DOI10.1016/j.ygeno.2003.08.020
CitationsScopus - 5Web of Science - 5
Co-authorsShaun Roman, Ben Curry
2004Aitken RJ, Ryan AL, Baker MA, McLaughlin EA, 'Redox activity associated with the maturation and capacitation of mammalian spermatozoa', Free Radical Biology and Medicine, 36 994-1010 (2004) [C1]
DOI10.1016/j.freeradbiomed.2004.01.017
CitationsScopus - 73Web of Science - 64
Co-authorsMark Baker, Eileen Mclaughlin
2004Aitken RJ, 'The Founder's Lecture: Human spermatozoa, fruits of creation, seeds of doubt', Reproduction Fertility and Development, 16 655-664 (2004) [C1]
DOI10.1071/RD04083
CitationsScopus - 43Web of Science - 39
2004Aitken RJ, Baker MA, 'Oxidative stress and male reproductive biology', Reproduction, Fertility and Development, 16 581-588 (2004) [C1]
DOI10.1071/RD03089
CitationsScopus - 130Web of Science - 121
Co-authorsMark Baker
2004Sidhu KS, Mate KE, Gunasekera T, Veal D, Hetherington L, Baker MA, et al., 'A flow cytometric assay for global estimation of tyrosine phosphorylation associated with capacitation of spermatozoa from two marsupial species, the tammar wallaby (Macropus eugenii) and the brushtail possum (Trichosurus vulpecula)', Reproduction, 127 95-103 (2004) [C1]
DOI10.1530/rep.1.00073
CitationsScopus - 18Web of Science - 19
Co-authorsKaren Mate, John Rodger, Mark Baker
2004Bennetts LE, Lin M, Aitken RJ, 'Cyclic AMP-Dependent Tyrosine Phosphorylation in Tammar Wallaby (Macropus eugenii) Spermatozoa', Journal of Experimental Zoology. Part A: Comparative Experimental Zoology, 301A 118-130 (2004) [C1]
DOI10.1002/jez.a.20020
CitationsScopus - 10Web of Science - 9
Co-authorsMinjie Lin
2003Aitken RJ, Ryan AL, Curry BJ, Baker MA, 'Multiple forms of redox activity in populations of human spermatozoa', Molecular Human Reproduction, 9 645-661 (2003) [C1]
DOI10.1093/molehr/gag086
CitationsScopus - 57Web of Science - 53
Co-authorsMark Baker, Ben Curry
2003Sawyer DE, Mercer BG, Wiklendt AM, Aitken RJ, 'Quantitative analysis of gene-specific DNA damage in human spermatozoa', Mutation Research, 21-34 (2003) [C1]
DOI10.1016/S0027-5107(03)00101-5
CitationsScopus - 61Web of Science - 59
2003Wade MA, Jones RC, Murdoch RN, Aitken RJ, 'Motility activation and second messenger signalling in spermatozoa from rat cauda epididymidis', Reproduction, 175-183 (2003) [C1]
DOI10.1530/reprod/125.2.175
CitationsScopus - 18Web of Science - 16
2003McLaughlin EA, Holland MK, Aitken RJ, 'Contraceptive vaccines', Expert Opinion on Biological Therapy, 3 829-841 (2003) [C1]
DOI10.1517/14712598.3.5.829
CitationsScopus - 11Web of Science - 8
Co-authorsEileen Mclaughlin
2003Aitken RJ, Baker MA, Sawyer DE, 'Oxidative stress in the male germ line and its role in the aetiology of male infertility and genetic disease', Reproductive BioMedicine, 7 65-70 (2003) [C1]
CitationsScopus - 133
Co-authorsMark Baker
2003Ecroyd HW, Jones RC, Aitken RJ, 'Tyrosine Phosphorylation of HSP-90 During Mammalian Sperm Capacitation', Biology of Reproduction, 1801-1807 (2003) [C1]
DOI10.1095/biolreprod.103.017350
CitationsScopus - 58Web of Science - 48
2003Ecroyd HW, Jones RC, Aitken RJ, 'Endogenous Redox Activity in Mouse Spermatozoa and Its Role in Regulating the Tyrosine Phosphorylation Events Associated with Sperm Capacitation', Biology of Reproduction, 347-354 (2003) [C1]
DOI10.1095/biolreprod.102.012716
CitationsScopus - 38Web of Science - 37
2003Baker MA, Krutskikh A, Aitken RJ, 'Biochemical entities involved in reactive oxygen species generation by human spermatozoa', Protoplasma, 145-151 (2003) [C1]
DOI10.1007/s00709-002-0057-0
CitationsScopus - 25Web of Science - 24
Co-authorsMark Baker
2003Aitken RJ, 'Reactive oxygen species generation by human spermatozoa: Reply', International Journal of Andrology, 26 127 (2003) [C3]
DOI10.1046/j.1365-2605.2003.00407.x
CitationsScopus - 2Web of Science - 2
2003Wade MA, Roman SD, Jones RC, Aitken RJ, 'Adenylyl cyclase isoforms in rat testis and spermatozoa from the cauda epididymidis', Cell and Tissue Research, 314 411-419 (2003) [C1]
DOI10.1007/s00441-003-0801-6
CitationsScopus - 16Web of Science - 16
Co-authorsShaun Roman
2003Baker MA, Lewis B, Hetherington L, Aitken RJ, 'Development of the Signalling Pathways Associated With Sperm Capacitation During Epididymal Maturation', Molecular Reproduction and Development, 446-457 (2003) [C1]
DOI10.1002/mrd.10255
CitationsScopus - 24Web of Science - 23
Co-authorsMark Baker
2002Aitken RJ, Marshall Graves H, 'The future of sex', Nature, 415 963 (2002) [C1]
DOI10.1038/415963a
CitationsScopus - 68Web of Science - 52
2002Aitken RJ, Baker MA, 'Reactive oxygen species generation by human spermatozoa: a continuing enigma', International Journal of Andrology, 25 191-194 (2002) [C1]
CitationsScopus - 38Web of Science - 35
Co-authorsMark Baker
2002Aitken RJ, 'Immunocontraceptive vaccines for human use', Journal of Reproductive Immunology, 57 273-287 (2002) [C1]
DOI10.1016/S0165-0378(02)00010-4
CitationsWeb of Science - 28
2002Lin M, Hess R, Aitken RJ, 'Induction of sperm maturation in vitro in epididymal cell cultures of the tammar wallaby (Macropus eugenii): disruption of motility initiation and sperm morphogenesis by inhibition of actin polymerization', Reproduction, 124 107-117 (2002) [C1]
CitationsScopus - 16Web of Science - 16
Co-authorsMinjie Lin
2002Paterson M, Jennings ZA, Wilson MR, Aitken RJ, 'the contraceptive potential of ZP3 and ZP3 peptides in a primate model.', Journal of Reproductive Immunology, 53 99-107 (2002)
2001Brown GK, Martin A, Roberts TK, Aitken RJ, 'Detection of Ehrlichia platys in dogs in Australia', Australian Veterinary Journal, 79 23-27 (2001) [C1]
CitationsScopus - 34Web of Science - 33
Co-authorsTim Roberts
2001Lewis B, Aitken RJ, 'Impact of epididymal maturation on the tyrosine phosphorylation patterns exhibited by rat spermatozoa', Biology of Reproduction, 64 1545-1556 (2001) [C1]
CitationsScopus - 38Web of Science - 36
2001Vernet P, Fulton N, Wallace C, Aitken RJ, 'Analysis of reactive oxygen species generating systems in rat epididymal spermatozoa', Biology of Reproduction, 65 1102-1113 (2001) [C1]
CitationsScopus - 76Web of Science - 68
2001Scarlett CJ, Lin M, Aitken RJ, 'Actin polymerisation during morphogenesis of the acrosome as spermatozoa undergo epididymal maturation in the tammar wallaby (Macropus eugenii)', Journal of Anatomy, 198 93-101 (2001) [C1]
DOI10.1017/S0021878200007299
CitationsScopus - 9Web of Science - 8
Co-authorsMinjie Lin, C Scarlett
2001Lewis B, Aitken RJ, 'A redox-regulated tyrosine phosphorylation cascade in rat spermatozoa', Journal of Andrology, 22 No. 4 611-622 (2001) [C1]
CitationsScopus - 63Web of Science - 62
2001Aitken RJ, Krausz C, 'Oxidative stress, DNA damage and the Y chromosome', Reproduction, 122 497-506 (2001) [C1]
CitationsWeb of Science - 322
2001Sawyer DE, Roman SD, Aitken RJ, 'Relative susceptibilities of mitochondrial and nuclear DNA to damage induced by hydrogen peroxide in two mouse germ cell lines', Redox Report, 6 No. 3 182-184 (2001) [C1]
DOI10.1179/135100001101536157
CitationsScopus - 31Web of Science - 33
Co-authorsShaun Roman
2000Eidne KA, Henery CC, Aitken RJ, 'Selection of peptides targeting the human sperm surface using random peptide phage display identify ligands homologous to ZP3', BIOLOGY OF REPRODUCTION, 63 1396-1402 (2000) [C1]
CitationsWeb of Science - 13
2000Kervancioglu ME, Saridogan E, Aitken RJ, Djahanbakhch O, 'Importance of sperm-to-epithelial cell contact for the capacitation of human spermatozoa in fallopian tube epithelial cell cocultures', FERTILITY AND STERILITY, 74 NO. 4 780-784 (2000) [C1]
DOI10.1016/S0015-0282(00)01514-4
CitationsScopus - 26Web of Science - 25
2000Aitken RJ, Buckingham DW, Richardson D, Gardiner JC, Irvine DS, 'Impact of deep saturation dive on semen quality', INTERNATIONAL JOURNAL OF ANDROLOGY, 23 116-120 (2000) [C1]
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2000Aitken RJ, Buckingham D, Richardson D, Gardiner JC, Irvine DS, 'Impact of a deep saturation dive on semen quality (vol 23, pg 116, 2000)', INTERNATIONAL JOURNAL OF ANDROLOGY, 23 253-253 (2000)
Author URL
2000Aitken RJ, 'Possible redox regulation of sperm motility activation', JOURNAL OF ANDROLOGY, 21, NO. 4 491-496 (2000) [C1]
CitationsScopus - 20Web of Science - 18
2000Irvine DS, Twigg JP, Gordon EL, Fulton N, Milne PA, Aitken RJ, 'DNA integrity in human spermatozoa: Relationships with semen quality', JOURNAL OF ANDROLOGY, 21 33-44 (2000)
Author URL
CitationsWeb of Science - 373
2000De S, Aitken RJ, 'Male-mediated developmental defects and childhood disease', Reproductive Medicine Review, 8 107-126 (2000)

Germline mutations have a tremendous impact on public health, since such damage is heritable, and thus transcends generations, as opposed to somatic mutations, which are confined to the individual (Figure 3). As recently as the mid-1980s, the prevailing view was that the male parent was an unlikely source of developmental defects. In the past decade, however, this notion has been seriously challenged. Several epidemiological studies demonstrate that paternal exposures can lead to germline mutations and a variety of developmental pathologies in offspring including spontaneous abortion, birth defects and childhood cancer. Currently, there is increasing concern regarding the declining health of the human male reproductive system, and the possibility of environmental toxicants as a major culprit. There is evidence that suggests a progressive decline in overall semen quality in recent decades, at least in Northern Europe. Sperm counts appear to be falling, and abnormal morphology is increasingly common. Other reproductive pathologies such as testicular cancer, hypospadias and cryptorchidism have risen with alarming rates in many highly industrialized areas, while cancers of the female reproductive tract (cervix, uterus, and ovarian) have remained relatively constant. In particular, men who work and live in heavily polluted areas have a greater tendency to sire offspring that die in utero, who are malformed, or who are at increased risk of developing childhood cancers. Moreover, sperm chromosome abnormalities, pregnancy loss and birth defects occur with much higher frequency in humans than in other species (Table 2). Because the severity of these pathologies appears to have increased within the last few decades, environmental factors are believed to be primarily responsible. Whether germline mutations in males are also increasing remains to be seen. The majority of birth defects (60-70%) are of unknown aetiology, and most human conceptions do not proceed to term. Smoking, poor semen quality (increased ROS levels from abnormal sperm and leukocytes), varicocele, infection, etc. can cause oxidative DNA damage in germ cells, and may be the 'missing link' in the aetiology of male germline mutations and paternally mediated developmental toxicity. The mechanisms by which environmental factors might stimulate mutations in the male germ line are not currently understood. However an exciting possibility that is consistent with our current understanding of the pathophysiology of male infertility is that oxidative stress is a key factor in the aetiology of such damage. ROS are clearly generated in excessive amounts by the spermatozoa of male patients, particularly those exhibiting a defective semen profile. This increase in free radical generation is associated with lipid peroxidation, oxidative base damage and DNA fragmentation, characterized by single- and double-strand breaks. It is known that spermatozoa exhibiting significant levels of oxidatively induced DNA fragmentation are capable of fertilization, and even severe levels of DNA fragmentation can be tolerated when ICSI is used to achieve conception. It is possible that the DNA fragmentation induced by oxidative stress can lead to a variety of human pathologies from early onset cancers to the induction of infertility itself. A correlation between DNA fragmentation in the male germline and childhood cancer in the offspring has already been observed in smokers. In addition, DNA fragmentation in spermatozoa may be the cause of the Y-chromosome deletions that are currently thought to underpin around 14% of all cases of severe oligo- or azoospermia. This hypothesis raises a large number of fundamental questions concerning the mechanisms responsible for creating oxidative stress in the male germline, the impact of such stress on the integrity of DNA in spermatozoa and the repair of such damage during early embryonic development. The clinical consequences of such damage in terms of the aetio...

DOI10.1017/S0962279900000211
CitationsScopus - 11
2000Paterson M, Jennings ZA, van Duin M, Aitken RJ, 'Immunocontraception with zone pellucida proteins', CELLS TISSUES ORGANS, 166 228-232 (2000)
DOI10.1159/000016735Author URL
CitationsWeb of Science - 18
2000Lin M, Zhang X, Murdoch RN, Aitken RJ, 'In vitro culture of brushtail possum (Trichosurus vulpecula) epididymal epithelium and induction of epididymal sperm maturation in co-culture', Journal of Reproduction and Fertility, 119 1-14 (2000) [C1]
CitationsWeb of Science - 9
Co-authorsMinjie Lin
1999Lewis BA, Aitken RJ, 'The regulation of tyrosine phosphorylation in rat epididymal spermatozoa by calcium', BIOLOGY OF REPRODUCTION, 60 146-147 (1999)
Author URL
1999Vernet P, Fulton N, Aitken RJ, 'Identification of two independent O(2)(- center dot)generating systems in rat epididymal spermatozoa.', BIOLOGY OF REPRODUCTION, 60 206-206 (1999)
Author URL
1999Young IE, Nawroz IM, Aitken RJ, 'Phaeochromocytoma of the spermatic cord', JOURNAL OF CLINICAL PATHOLOGY, 52 305-306 (1999)
Author URL
CitationsScopus - 5Web of Science - 5
1999Aitken RJ, 'The Amoroso Lecture - The human spermatozoon - a cell in crisis?', JOURNAL OF REPRODUCTION AND FERTILITY, 115 1-7 (1999)
Author URL
CitationsWeb of Science - 219
1999Scobie GA, Kerr LE, MacDuff P, Aitken RJ, 'Cloning, sequencing and site of origin of the rat sperm receptor protein, ZP3', ZYGOTE, 7 27-+ (1999)
DOI10.1017/S0967199499000362Author URL
CitationsWeb of Science - 4
1999Paterson M, Wilson MR, Jennings ZA, van Duin M, Aitken RJ, 'Design and evaluation of a ZP3 peptide vaccine in a homologous primate model.', Mol Hum Reprod, 5 342-352 (1999)
Author URL
1998Aitken RJ, Harkiss D, Knox W, Paterson M, Irvine S, 'On the cellular mechanisms by which the bicarbonate ion mediates the extragenomic action of progesterone on human spermatozoa', BIOLOGY OF REPRODUCTION, 58 186-196 (1998)
DOI10.1095/biolreprod58.1.186Author URL
CitationsWeb of Science - 41
1998Aitken RJ, Gordon E, Harkiss D, Twigg JP, Milne P, Jennings Z, Irvine DS, 'Relative impact of oxidative stress on the functional competence and genomic integrity of human spermatozoa', BIOLOGY OF REPRODUCTION, 59 1037-1046 (1998)
DOI10.1095/biolreprod59.5.1037Author URL
CitationsWeb of Science - 390
1998Aitken RJ, Harkiss D, Knox W, Paterson M, Irvine DS, 'A novel signal transduction cascade in capacitating human spermatozoa characterised by a redox-regulated, cAMP-mediated induction of tyrosine phosphorylation', JOURNAL OF CELL SCIENCE, 111 645-656 (1998)
Author URL
CitationsWeb of Science - 211
1998Aitken RJ, Vernet P, 'Maturation of redox regulatory mechanisms in the epididymis', JOURNAL OF REPRODUCTION AND FERTILITY, 109-118 (1998)
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CitationsScopus - 40
1998Gomez E, Irvine DS, Aitken RJ, 'Evaluation of a spectrophotometric assay for the measurement of malondialdehyde and 4-hydroxyalkenals in human spermatozoa: relationships with semen quality and sperm function', INTERNATIONAL JOURNAL OF ANDROLOGY, 21 81-94 (1998)
Author URL
CitationsWeb of Science - 95
1998Kerr LE, Paterson M, Aitken RJ, 'Molecular basis of sperm-egg interaction and the prospects for immunocontraception', JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 40 103-118 (1998)
DOI10.1016/S0165-0378(98)00039-4Author URL
CitationsWeb of Science - 8
1998Twigg JP, Irvine DS, Aitken RJ, 'Oxidative damage to DNA in human spermatozoa does not preclude pronucleus formation at intracytoplasmic sperm injection', HUMAN REPRODUCTION, 13 1864-1871 (1998)
DOI10.1093/humrep/13.7.1864Author URL
CitationsWeb of Science - 215
1998Twigg J, Fulton N, Gomez E, Irvine DS, Aitken RJ, 'Analysis of the impact of intracellular reactive oxygen species generation on the structural and functional integrity of human spermatozoa: lipid peroxidation, DNA fragmentation and effectiveness of antioxidants', HUMAN REPRODUCTION, 13 1429-1436 (1998)
DOI10.1093/humrep/13.6.1429Author URL
CitationsWeb of Science - 197
1998Twigg J, Irvine DS, Houston P, Fulton N, Michael L, Aitken RJ, 'Iatrogenic DNA damage induced in human spermatozoa during sperm preparation: protective significance of seminal plasma', MOLECULAR HUMAN REPRODUCTION, 4 439-445 (1998)
DOI10.1093/molehr/4.5.439Author URL
CitationsWeb of Science - 100
1998Paterson M, Wilson MR, Morris KD, van Duin M, Aitken RJ, 'Evaluation of the contraceptive potential of recombinant human ZP3 and human ZP3 peptides in a primate model: Their safety and efficacy', AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 40 198-209 (1998)
Author URL
CitationsWeb of Science - 54
1998Kerr LE, Paterson M, Aitken RJ, 'Review: Molecular basis of sperm-egg interaction and the prospects', Journal of Reproductive Immunology, 40 103-118 (1998)
1997Aitken RJ, 'Molecular mechanisms regulating human sperm function', MOLECULAR HUMAN REPRODUCTION, 3 169-173 (1997)
DOI10.1093/molehr/3.3.169Author URL
CitationsWeb of Science - 110
1997Sakka E, 'Protein kinase C- and Ca2+ ionophore-stimulated production of reactive oxygen species in mechanically dispersed isolated bovine luteal cells', Biology of Reproduction, 57 428-435 (1997)
DOI10.1095/biolreprod57.2.428
1997Allan IW, Irvine DS, Macnamee M, Aitken RJ, 'Field trial of a diluent for the transportation of human semen at ambient temperatures', FERTILITY AND STERILITY, 67 348-354 (1997)
DOI10.1016/S0015-0282(97)81922-XAuthor URL
CitationsWeb of Science - 10
1997Aitken RJ, 'Need: A special medline - For prior to 1966 - Reply', FERTILITY AND STERILITY, 68 181-181 (1997)
Author URL
1997Fisher HM, Aitken RJ, 'Comparative analysis of the ability of precursor germ cells and epididymal spermatozoa to generate reactive oxygen metabolites', JOURNAL OF EXPERIMENTAL ZOOLOGY, 277 390-400 (1997)
DOI10.1002/(SICI)1097-010X(19970401)277:5<390::AID-JEZ5>3.0.CO;2-KAuthor URL
CitationsWeb of Science - 81
1997Flaherty SP, Michalowska J, Swann NJ, Dmowski WP, Matthews CD, Aitken RJ, 'Albumin gradients do not enrich Y-bearing human spermatozoa', HUMAN REPRODUCTION, 12 938-942 (1997)
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CitationsWeb of Science - 15
1997Aitken RJ, 'The extragenomic action of progesterone on human spermatozoa', HUMAN REPRODUCTION, 12 38-42 (1997)
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CitationsWeb of Science - 9
1997Aitken RJ, 'Sex steroids and fertilization', HUMAN REPRODUCTION, 12 S5-S5 (1997)
Author URL
1997Aitken RJ, 'Free oxygen radicals and human sperm function', HUMAN REPRODUCTION, 12 O27-O27 (1997)
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1997Twigg JP, Irvine DS, Aitken RJ, 'Exposure of human spermatozoa to reactive oxygen species enhances chromatin cross-linking and stimulates DNA strand breakage', HUMAN REPRODUCTION, 12 O118-O118 (1997)
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1997Aitken RJ, 'How to select viable spermatozoa for ICSI', HUMAN REPRODUCTION, 12 O129-O129 (1997)
Author URL
1997Paterson M, Wilson MR, vanDuin M, Aitken RJ, 'Evaluation of the contraceptive potential of antibodies to an immunodominant marmoset ZP3 peptide which recognize human zona pellucida', HUMAN REPRODUCTION, 12 P129-P129 (1997)
Author URL
1997Kerr LE, Brindle JP, Saxty BA, vanDuin M, Aitken RJ, 'Identification of novel sperm antigens with potential as immunocontraceptives', HUMAN REPRODUCTION, 12 P130-P130 (1997)
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1997MacDuff PE, Kerr LE, Aitken RJ, 'Molecular characterization of the zona pellucida glycoproteins ZP1, ZP2 and ZP3 in the rat', HUMAN REPRODUCTION, 12 P163-P163 (1997)
Author URL
1997Knox W, Harkiss HDJ, Irvine DS, Aitken RJ, 'Impact of tyrosine phosphorylation status on the generation of calcium transients in human spermatozoa following exposure to progesterone', HUMAN REPRODUCTION, 12 P164-P164 (1997)
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1997Fulton N, Fisher H, Paterson M, Irvine DS, Aitken RJ, 'Purification and characterization of NADPH oxidase in human spermatozoa', HUMAN REPRODUCTION, 12 P165-P165 (1997)
Author URL
1997vanDuin M, Grootenhuis A, Bunschoten H, Aitken RJ, 'Production and characterization of monoclonal antibodies against human ZP3 that inhibit human sperm-zona pellucida binding', HUMAN REPRODUCTION, 12 R127-R127 (1997)
Author URL
1997Rossi AG, Aitken RJ, 'Interactions between leukocytes and the male reproductive system: The unanswered questions', FATE OF THE MALE GERM CELL, 424 245-252 (1997)
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CitationsScopus - 6Web of Science - 8
1997Aitken RJ, 'The cell biology of fertilization', FATE OF THE MALE GERM CELL, 424 291-299 (1997)
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CitationsWeb of Science - 6
1997Saxty B, Aitken J, 'Sperm surface antigens and the prospects for contraceptive vaccine development', Reproductive Medicine Review, 6 81-81 (1997)
DOI10.1017/S0962279900001435
1997Aitken RJ, Fisher HM, Fulton N, Gomez E, Knox W, Lewis B, Irvine S, 'Reactive oxygen species generation by human spermatozoa is induced by exogenous NADPH and inhibited by the flavoprotein inhibitors diphenylene iodonium and quinacrine', MOLECULAR REPRODUCTION AND DEVELOPMENT, 47 468-482 (1997)
DOI10.1002/(SICI)1098-2795(199708)47:4<468::AID-MRD14>3.0.CO;2-SAuthor URL
CitationsWeb of Science - 159
1996Aitken RJ, Buckingham DW, Irvine DS, 'The extragenomic action of progesterone on human spermatozoa: Evidence for a ubiquitous response that is rapidly down-regulated', ENDOCRINOLOGY, 137 3999-4009 (1996)
DOI10.1210/en.137.9.3999Author URL
CitationsWeb of Science - 56
1996Baker HWG, Brindle J, Irvine DS, Aitken RJ, 'Protective effect of antioxidants on the impairment of sperm motility by activated polymorphonuclear leukocytes', FERTILITY AND STERILITY, 65 411-419 (1996)
Author URL
CitationsWeb of Science - 115
1996Aitken RJ, Irvine DS, 'Reproductive biology - Fertilization without sperm', NATURE, 379 493-& (1996)
DOI10.1038/379493a0Author URL
CitationsWeb of Science - 12
1996Gomez E, Buckingham DW, Brindle J, Lanzafame F, Irvine DS, Aitken RJ, 'Development of an image analysis system to monitor the retention of residual cytoplasm by human spermatozoa: Correlation with biochemical markers of the cytoplasmic space, oxidative stress, and sperm function', JOURNAL OF ANDROLOGY, 17 276-287 (1996)
Author URL
CitationsWeb of Science - 182
1996Sukcharoen N, Keith J, Irvine DS, Aitken RJ, 'Prediction of the in-vitro fertilization (IVF) potential of human spermatozoa using sperm function tests: The effect of the delay between testing and IVF', HUMAN REPRODUCTION, 11 1030-1034 (1996)
Author URL
CitationsScopus - 71Web of Science - 67
1996Aitken RJ, Allan IW, Irvine DS, Macnamee M, 'Studies on the development of diluents for the transportation and storage of human semen at ambient temperature', HUMAN REPRODUCTION, 11 2186-2196 (1996)
Author URL
CitationsWeb of Science - 12
1996Aitken RJ, Buckingham DW, Harkiss D, Paterson M, Fisher H, Irvine DS, 'The extragenomic action of progesterone on human spermatozoa is influenced by redox regulated changes in tyrosine phosphorylation during capacitation', MOLECULAR AND CELLULAR ENDOCRINOLOGY, 117 83-93 (1996)
DOI10.1016/0303-7207(95)03733-0Author URL
CitationsWeb of Science - 94
1996Paterson M, Wilson MR, vanDuin M, Aitken RJ, 'Evaluation of zona pellucida antigens as potential candidates for immunocontraception', ZONA PELLUCIDA GLYCOPROTEINS AND IMMUNOCONTRACEPTION, 175-182 (1996)
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CitationsScopus - 30
1996Aitken RJ, Buckingham DW, Carreras A, Irvine DS, 'Superoxide dismutase in human sperm suspensions: Relationship with cellular composition, oxidative stress, and sperm function', FREE RADICAL BIOLOGY AND MEDICINE, 21 495-504 (1996)
DOI10.1016/0891-5849(96)00119-0Author URL
CitationsWeb of Science - 61
1996Aitken RJ, Paterson M, vanDuin M, 'The potential of the zona pellucida as a target for immunocontraception', AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 35 175-180 (1996)
Author URL
CitationsWeb of Science - 27
1996Aitken RJ, Buckingham DW, West K, Brindle J, 'On the use of paramagnetic beads and ferrofluids to assess and eliminate the leukocytic contribution to oxygen radical generation by human sperm suspensions', AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 35 541-551 (1996)
Author URL
CitationsWeb of Science - 52
1996Irvine S, Cawood E, Richardson D, MacDonald E, Aitken RJ, 'Evidence of deteriorating semen quality in the United Kingdom: birth cohort study in 577 men in Scotland over 11 years', British Medical Journal, 312 467-471 (1996)
1996Gomez E, Aitken RJ, 'Impact of IVF-ET culture media on peroxidative damage to human spermatozoa.', Fertility and sterility, 65 880-882 (1996)
1995Aitken RJ, 'The bioassay of sperm function', Fertility and Sterility, 63 1134-1134 (1995)
1995Aitken RJ, 'Male infertility, prognostic value of old and new tests', Reviews in Assisted Conception, 5 26-31 (1995)
1995WHITE DR, CLARKSON JS, RATNASOORIYA WD, AITKEN RJ, 'COMPLEMENTARY EFFECTS OF PROPRANOLOL AND NONOXYNOL-9 UPON HUMAN SPERM MOTILITY', CONTRACEPTION, 52 241-247 (1995)
DOI10.1016/0010-7824(95)00190-LAuthor URL
CitationsWeb of Science - 11
1995AITKEN RJ, 'FUTURE OF THE HAMSTER OOCYTE PENETRATION ASSAY - REPLY', FERTILITY AND STERILITY, 63 1134-1135 (1995)
Author URL
1995SUKCHAROEN N, KEITH J, IRVINE DS, AITKEN RJ, 'PREDICTING THE FERTILIZING POTENTIAL OF HUMAN SPERM SUSPENSIONS IN-VITRO - IMPORTANCE OF SPERM MORPHOLOGY AND LEUKOCYTE CONTAMINATION', FERTILITY AND STERILITY, 63 1293-1300 (1995)
Author URL
CitationsWeb of Science - 100
1995AITKEN RJ, PATERSON M, FISHER H, BUCKINGHAM DW, VANDUIN M, 'REDOX REGULATION OF TYROSINE PHOSPHORYLATION IN HUMAN SPERMATOZOA AND ITS ROLE IN THE CONTROL OF HUMAN SPERM FUNCTION', JOURNAL OF CELL SCIENCE, 108 2017-2025 (1995)
Author URL
CitationsWeb of Science - 277
1995AITKEN RJ, 'THE COMPLEXITIES OF CONCEPTION', SCIENCE, 269 39-40 (1995)
DOI10.1126/science.7604276Author URL
CitationsWeb of Science - 17
1995AITKEN RJ, BAKER HWG, IRVINE DS, 'ON THE NATURE OF SEMEN QUALITY AND INFERTILITY', HUMAN REPRODUCTION, 10 248-249 (1995)
Author URL
CitationsWeb of Science - 21
1995AITKEN RJ, BAKER HWG, 'SEMINAL LEUKOCYTES - PASSENGERS, TERRORISTS OR GOOD-SAMARITANS', HUMAN REPRODUCTION, 10 1736-1739 (1995)
Author URL
CitationsScopus - 119Web of Science - 101
1995AITKEN RJ, BUCKINGHAM DW, BRINDLE J, GOMEZ E, BAKER HWG, IRVINE DS, 'ANALYSIS OF SPERM MOVEMENT IN RELATION TO THE OXIDATIVE STRESS CREATED BY LEUKOCYTES IN WASHED SPERM PREPARATIONS AND SEMINAL PLASMA', HUMAN REPRODUCTION, 10 2061-2071 (1995)
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CitationsWeb of Science - 120
1995IRVINE DS, CAWOOD EHH, RICHARDSON DW, MACDONALD E, AITKEN RJ, 'A SURVEY OF SEMEN DONATION - PHASE-II THE VIEW OF THE DONORS', HUMAN REPRODUCTION, 10 2752-2753 (1995)
Author URL
CitationsWeb of Science - 2
1995Sukcharoen N, Keith J, Irvine DS, Aitken RJ, 'Definition of the optimal criteria for identifying hyperactivated human spermatozoa at 25 Hz using in-vitro fertilization as a functional end-point', HUMAN REPRODUCTION, 10 2928-2937 (1995)
Author URL
CitationsScopus - 47Web of Science - 44
1994VANDUIN M, POLMAN JEM, DEBREET ITM, VANGINNEKEN K, BUNSCHOTEN H, GROOTENHUIS A, et al., 'RECOMBINANT HUMAN ZONA-PELLUCIDA PROTEIN ZP3 PRODUCED BY CHINESE-HAMSTER OVARY CELLS INDUCES THE HUMAN SPERM ACROSOME REACTION AND PROMOTES SPERM-EGG FUSION', BIOLOGY OF REPRODUCTION, 51 607-617 (1994)
DOI10.1095/biolreprod51.4.607Author URL
CitationsWeb of Science - 127
1994HOKKE CH, DAMM JBL, PENNINKHOF B, AITKEN RJ, KAMERLING JP, VLIEGENTHART JFG, 'STRUCTURE OF THE O-LINKED CARBOHYDRATE CHAINS OF PORCINE ZONA-PELLUCIDA GLYCOPROTEINS', EUROPEAN JOURNAL OF BIOCHEMISTRY, 221 491-512 (1994)
DOI10.1111/j.1432-1033.1994.tb18762.xAuthor URL
CitationsWeb of Science - 81
1994KERVANCIOGLU ME, DJAHANBAKHCH O, AITKEN RJ, 'EPITHELIAL-CELL COCULTURE AND THE INDUCTION OF SPERM CAPACITATION', FERTILITY AND STERILITY, 61 1103-1108 (1994)
Author URL
CitationsWeb of Science - 59
1994KRAUSZ C, MILLS C, ROGERS S, TAN SL, AITKEN RJ, 'STIMULATION OF OXIDANT GENERATION BY HUMAN SPERM SUSPENSIONS USING PHORBOL ESTERS AND FORMYL PEPTIDES - RELATIONSHIPS WITH MOTILITY AND FERTILIZATION IN-VITRO', FERTILITY AND STERILITY, 62 599-605 (1994)
Author URL
CitationsWeb of Science - 76
1994AITKEN RJ, WEST K, BUCKINGHAM D, 'LEUKOCYTIC INFILTRATION INTO THE HUMAN EJACULATE AND ITS ASSOCIATION WITH SEMEN QUALITY, OXIDATIVE STRESS, AND SPERM FUNCTION', JOURNAL OF ANDROLOGY, 15 343-352 (1994)
Author URL
CitationsWeb of Science - 125
1994IRVINE DS, AITKEN RJ, 'SEMINAL FLUID ANALYSIS AND SPERM FUNCTION TESTING', ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA, 23 725-748 (1994)
Author URL
CitationsWeb of Science - 27
1994AITKEN RJ, 'A FREE-RADICAL THEORY OF MALE-INFERTILITY', REPRODUCTION FERTILITY AND DEVELOPMENT, 6 19-24 (1994)
DOI10.1071/RD9940019Author URL
CitationsScopus - 208Web of Science - 186
1994AITKEN RJ, 'PATHOPHYSIOLOGY OF HUMAN SPERMATOZOA', CURRENT OPINION IN OBSTETRICS & GYNECOLOGY, 6 128-135 (1994)
Author URL
CitationsWeb of Science - 33
1994Irvine DS, Aitken RJ, 'Falling sperm quality', BMJ: British Medical Journal, 309 476-476 (1994)
1994Aitken RJ, Fisher H, 'Reactive oxygen species generation and human spermatozoa, the balance of benefit and risk', BioEssays, 16 259-268 (1994)
1994Aitken RJ, 'The future of the hamster oocyte penetration assay', Fertility and Sterility, 62 17-19 (1994)
1994Aitken RJ, buckingham D, Harkiss D, 'Analysis of the extent to which sperm movement can predict the results of ionophore-enhanced functional assays of the acrosome reaction and sperm-oocyte fusion', Human Reproduction, 9 1867-1874 (1994)
1994Aitken RJ, Krausz C, Buckingham DW, 'Relationships between biochemical markers for residual sperm cytoplasm, reactive oxygen species generation and the presence of leucocytes and precursor germ cells in human sperm suspensions', Molecular Reproduction and Development, 39 268-279 (1994)
1993AITKEN RJ, PATERSON M, KOOTHAN PT, 'CONTRACEPTIVE VACCINES', BRITISH MEDICAL BULLETIN, 49 88-99 (1993)
Author URL
CitationsScopus - 11Web of Science - 16
1993AITKEN RJ, BUCKINGHAM D, HARKISS D, 'USE OF A XANTHINE-OXIDASE FREE-RADICAL GENERATING-SYSTEM TO INVESTIGATE THE CYTOTOXIC EFFECTS OF REACTIVE OXYGEN SPECIES ON HUMAN SPERMATOZOA', JOURNAL OF REPRODUCTION AND FERTILITY, 97 441-450 (1993)
Author URL
CitationsWeb of Science - 209
1993AITKEN RJ, HARKISS D, BUCKINGHAM D, 'RELATIONSHIP BETWEEN IRON-CATALYZED LIPID-PEROXIDATION POTENTIAL AND HUMAN SPERM FUNCTION', JOURNAL OF REPRODUCTION AND FERTILITY, 98 257-265 (1993)
Author URL
CitationsWeb of Science - 166
1993AITKEN RJ, BUCKINGHAM DW, FANG HG, 'ANALYSIS OF THE RESPONSES OF HUMAN SPERMATOZOA TO A23187 EMPLOYING A NOVEL TECHNIQUE FOR ASSESSING THE ACROSOME REACTION', JOURNAL OF ANDROLOGY, 14 132-141 (1993)
Author URL
CitationsWeb of Science - 102
1993AITKEN RJ, BRINDLE JP, 'ANALYSIS OF THE ABILITY OF 3 PROBES TARGETING THE OUTER ACROSOMAL MEMBRANE OR ACROSOMAL CONTENTS TO DETECT THE ACROSOME REACTION IN HUMAN SPERMATOZOA', HUMAN REPRODUCTION, 8 1663-1669 (1993)
Author URL
CitationsWeb of Science - 37
1993Thillai-Koothan P, van Duin M, Aitken RJ, 'Cloning, sequencing and oocyte-specific expression of the marmoset sperm receptor protein, ZP3', ZYGOTE, 1 93-101 (1993)
Author URL
CitationsScopus - 21Web of Science - 27
1993AITKEN RJ, HARKISS D, BUCKINGHAM DW, 'ANALYSIS OF LIPID-PEROXIDATION MECHANISMS IN HUMAN SPERMATOZOA', MOLECULAR REPRODUCTION AND DEVELOPMENT, 35 302-315 (1993)
DOI10.1002/mrd.1080350313Author URL
CitationsWeb of Science - 184
1993Van Duin M, Polman JEM, Verkoelen CEH, Aitken RJ, 'Cloning and characterization of the human sperm receptor ligand ZP3, evidence for a second polymorphic allele with a different frequency in the Caucasian and Japanese populations', Genomics, 14 1064-1070 (1993)
1992AITKEN RJ, 'CRITERIA FOR THE DIAGNOSIS OF INFERTILITY - REPLY', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 166 264-265 (1992)
Author URL
CitationsWeb of Science - 1
1992PATERSON M, KOOTHAN PT, MORRIS KD, OBYRNE KT, BRAUDE P, WILLIAMS A, AITKEN RJ, 'ANALYSIS OF THE CONTRACEPTIVE POTENTIAL OF ANTIBODIES AGAINST NATIVE AND DEGLYCOSYLATED PORCINE ZP3 INVIVO AND INVITRO', BIOLOGY OF REPRODUCTION, 46 523-534 (1992)
DOI10.1095/biolreprod46.4.523Author URL
CitationsScopus - 73Web of Science - 91
1992AITKEN RJ, FORREST APM, CHETTY U, ROBERTS MM, HUGGINS A, MACDONALD HL, et al., 'ASSESSMENT OF NONPALPABLE MAMMOGRAPHIC ABNORMALITIES - COMPARISON BETWEEN SCREENING AND SYMPTOMATIC CLINICS', BRITISH JOURNAL OF SURGERY, 79 925-927 (1992)
DOI10.1002/bjs.1800790923Author URL
CitationsWeb of Science - 3
1992WU FCW, AITKEN RJ, 'SPERM MORPHOLOGY - PREDICTIVE VALUE - REPLY', FERTILITY AND STERILITY, 57 942-943 (1992)
Author URL
1992KRAUSZ C, WEST K, BUCKINGHAM D, AITKEN RJ, 'DEVELOPMENT OF A TECHNIQUE FOR MONITORING THE CONTAMINATION OF HUMAN SEMEN SAMPLES WITH LEUKOCYTES', FERTILITY AND STERILITY, 57 1317-1325 (1992)
Author URL
CitationsWeb of Science - 73
1992AITKEN RJ, BUCKINGHAM DW, WEST KM, 'REACTIVE OXYGEN SPECIES AND HUMAN SPERMATOZOA - ANALYSIS OF THE CELLULAR MECHANISMS INVOLVED IN LUMINOL-DEPENDENT AND LUCIGENIN-DEPENDENT CHEMILUMINESCENCE', JOURNAL OF CELLULAR PHYSIOLOGY, 151 466-477 (1992)
DOI10.1002/jcp.1041510305Author URL
CitationsWeb of Science - 159
1992AITKEN RJ, BUCKINGHAM D, WEST K, WU FC, ZIKOPOULOS K, RICHARDSON DW, 'DIFFERENTIAL CONTRIBUTION OF LEUKOCYTES AND SPERMATOZOA TO THE GENERATION OF REACTIVE OXYGEN SPECIES IN THE EJACULATES OF OLIGOZOOSPERMIC PATIENTS AND FERTILE DONORS', JOURNAL OF REPRODUCTION AND FERTILITY, 94 451-462 (1992)
Author URL
CitationsWeb of Science - 204
1992AITKEN RJ, BUCKINGHAM D, 'ENHANCED DETECTION OF REACTIVE OXYGEN SPECIES PRODUCED BY HUMAN SPERMATOZOA WITH 7-DIMETHYL AMINO-NAPHTHALIN-1, 2-DICARBONIC ACID HYDRAZIDE', INTERNATIONAL JOURNAL OF ANDROLOGY, 15 211-219 (1992)
DOI10.1111/j.1365-2605.1992.tb01341.xAuthor URL
CitationsWeb of Science - 17
1992WALLACE EM, AITKEN RJ, WU FCW, 'RESIDUAL SPERM FUNCTION IN OLIGOZOOSPERMIA INDUCED BY TESTOSTERONE ENANTHATE ADMINISTERED AS A POTENTIAL STEROID MALE CONTRACEPTIVE', INTERNATIONAL JOURNAL OF ANDROLOGY, 15 416-424 (1992)
DOI10.1111/j.1365-2605.1992.tb01356.xAuthor URL
CitationsWeb of Science - 19
1992AITKEN RJ, BOWIE H, BUCKINGHAM D, HARKISS D, RICHARDSON DW, WEST KM, 'SPERM PENETRATION INTO A HYALURONIC-ACID POLYMER AS A MEANS OF MONITORING FUNCTIONAL COMPETENCE', JOURNAL OF ANDROLOGY, 13 44-54 (1992)
Author URL
CitationsWeb of Science - 58
1992VANDUIN M, POLMAN JEM, VERKOELEN CCEH, BUNSCHOTEN H, MEYERINK JH, OLIJVE W, AITKEN RJ, 'CLONING AND CHARACTERIZATION OF THE HUMAN SPERM RECEPTOR LIGAND ZP3 - EVIDENCE FOR A 2ND POLYMORPHIC ALLELE WITH A DIFFERENT FREQUENCY IN THE CAUCASIAN AND JAPANESE POPULATIONS', GENOMICS, 14 1064-1070 (1992)
DOI10.1016/S0888-7543(05)80130-2Author URL
CitationsScopus - 18Web of Science - 27
1992Aitken RJ, 'A family of fusion proteins', Nature, 196-197 (1992)
1991AITKEN RJ, IRVINE DS, WU FC, 'PROSPECTIVE ANALYSIS OF SPERM-OOCYTE FUSION AND REACTIVE OXYGEN SPECIES GENERATION AS CRITERIA FOR THE DIAGNOSIS OF INFERTILITY', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 164 542-551 (1991)
Author URL
CitationsWeb of Science - 253
1991Aitken RJ, 'The 17th Jennifer Hallam Memorial Lecture: Immunocontraception', British Journal of Family Planning, 16 3-7 (1991)
1991SANCHEZ R, TOEPFERPETERSEN E, AITKEN RJ, SCHILL WB, 'A NEW METHOD FOR EVALUATION OF THE ACROSOME REACTION IN VIABLE HUMAN SPERMATOZOA', ANDROLOGIA, 23 197-203 (1991) [C1]
Author URL
CitationsWeb of Science - 30
1991Aitken RJ, 'Human spermatozoa in assisted reproduction', International Journal of Andrology, 14 75-75 (1991)
DOI10.1111/j.1365-2605.1991
1991Aitken RJ, 'Do sperm find eggs attractive?', Nature, 19-20 (1991)
1991Aitken RJ, 'A clue to Kartageners', Nature, 306-306 (1991)
1990AITKEN RJ, 'EVALUATION OF HUMAN SPERM FUNCTION', BRITISH MEDICAL BULLETIN, 46 654-674 (1990)
Author URL
CitationsScopus - 12Web of Science - 17
1990AITKEN RJ, 'CONTRACEPTIVE VACCINE DEVELOPMENT', EUROPEAN JOURNAL OF PHARMACOLOGY, 183 13-13 (1990)
DOI10.1016/0014-2999(90)91256-BAuthor URL
1990AITKEN RJ, KERR L, BOLTON V, HARGREAVE T, 'ANALYSIS OF SPERM FUNCTION IN GLOBOZOOSPERMIA - IMPLICATIONS FOR THE MECHANISM OF SPERM-ZONA INTERACTION', FERTILITY AND STERILITY, 54 701-707 (1990)
Author URL
CitationsWeb of Science - 42
1990WU FCW, AITKEN RJ, FERGUSON A, 'EFFECT OF SULFASALAZINE ON SPERMATOGENESIS - REPLY', FERTILITY AND STERILITY, 54 747-748 (1990)
Author URL
1990AITKEN RJ, WEST KM, 'ANALYSIS OF THE RELATIONSHIP BETWEEN REACTIVE OXYGEN SPECIES PRODUCTION AND LEUKOCYTE INFILTRATION IN FRACTIONS OF HUMAN SEMEN SEPARATED ON PERCOLL GRADIENTS', INTERNATIONAL JOURNAL OF ANDROLOGY, 13 433-451 (1990)
DOI10.1111/j.1365-2605.1990.tb01051.xAuthor URL
CitationsWeb of Science - 193
1990NASRESFAHANI M, JOHNSON MH, AITKEN RJ, 'THE EFFECT OF IRON AND IRON CHELATORS ON THE INVITRO BLOCK TO DEVELOPMENT OF THE MOUSE PREIMPLANTATION EMBRYO - BAT6 A NEW MEDIUM FOR IMPROVED CULTURE OF MOUSE EMBRYOS INVITRO', HUMAN REPRODUCTION, 5 997-1003 (1990)
Author URL
CitationsScopus - 69Web of Science - 100
1990Aitken RJ, 'Cell biology of defective sperm function', Cell Biology International Reports, 33 (1990)
1990AITKEN RJ, 'DEVELOPMENT OF INVITRO TESTS OF HUMAN SPERM FUNCTION - A DIAGNOSTIC-TOOL AND MODEL SYSTEM FOR TOXICOLOGICAL ANALYSES', TOXICOLOGY IN VITRO, 4 560-569 (1990)
DOI10.1016/0887-2333(90)90116-BAuthor URL
CitationsScopus - 14Web of Science - 15
1990PATERSON M, AITKEN RJ, 'DEVELOPMENT OF VACCINES TARGETING THE ZONA-PELLUCIDA', CURRENT OPINION IN IMMUNOLOGY, 2 743-747 (1990)
DOI10.1016/0952-7915(90)90043-GAuthor URL
CitationsScopus - 5Web of Science - 11
1990BRAUDE P, JOHNSON MH, AITKEN RJ, 'HUMAN FERTILIZATION AND EMBRYOLOGY BILL GOES TO REPORT STAGE', BRITISH MEDICAL JOURNAL, 300 1410-1412 (1990)
Author URL
CitationsWeb of Science - 12
1990Braude P, Johnson MH, Aitken RJ, 'Human Fertilisation and Embryology Bill goes to report stage. Donor anonymity to go? Is GIFT included?', British Medical Journal, 300 1410-1412 (1990)
CitationsScopus - 5
1990Paterson M, Aitken RJ, 'Development of vaccines targeting the zona pellucida', Current Opinions in immunology, 743-747 (1990)
1990Nasr-Esfahani M, Aitken RJ, 'The measurement of H202 levels in preimplantation embryos from blocking and non-blocking strains of mice', Development, 501-507 (1990)
1990Aitken RJ, 'Viable offspring', Nature, 588-588 (1990)
1989AITKEN RJ, CLARKSON JS, FISHEL S, 'GENERATION OF REACTIVE OXYGEN SPECIES, LIPID-PEROXIDATION, AND HUMAN-SPERM FUNCTION', BIOLOGY OF REPRODUCTION, 41 183-197 (1989)
DOI10.1095/biolreprod41.1.183Author URL
CitationsScopus - 613Web of Science - 362
1989WU FCW, AITKEN RJ, FERGUSON A, 'INFLAMMATORY BOWEL-DISEASE AND MALE-INFERTILITY - EFFECTS OF SULFASALAZINE AND 5-AMINOSALICYLIC ACID ON SPERM-FERTILIZING CAPACITY AND REACTIVE OXYGEN SPECIES GENERATION', FERTILITY AND STERILITY, 52 842-845 (1989)
Author URL
CitationsScopus - 15Web of Science - 19
1989WU FCW, AITKEN RJ, 'SUPPRESSION OF SPERM FUNCTION BY DEPOT MEDROXYPROGESTERONE ACETATE AND TESTOSTERONE ENANTHATE IN STEROID MALE CONTRACEPTION', FERTILITY AND STERILITY, 51 691-698 (1989)
Author URL
CitationsScopus - 44Web of Science - 54
1989AITKEN RJ, GAZE MN, RODGER A, CHETTY U, FORREST APM, 'ARM MORBIDITY WITHIN A TRIAL OF MASTECTOMY AND EITHER NODAL SAMPLE WITH SELECTIVE RADIOTHERAPY OR AXILLARY CLEARANCE', SURGERY, 106 A13-A16 (1989)
Author URL
1989WHITE DR, AITKEN RJ, 'INFLUENCE OF EPIDIDYMAL MATURATION ON CYCLIC-AMP LEVELS IN HAMSTER SPERMATOZOA', INTERNATIONAL JOURNAL OF ANDROLOGY, 12 29-43 (1989)
DOI10.1111/j.1365-2605.1989.tb01283.xAuthor URL
CitationsScopus - 7Web of Science - 7
1989AITKEN RJ, 'THE ROLE OF FREE OXYGEN RADICALS AND SPERM FUNCTION', INTERNATIONAL JOURNAL OF ANDROLOGY, 12 95-97 (1989)
DOI10.1111/j.1365-2605.1989.tb01290.xAuthor URL
CitationsWeb of Science - 79
1989Aitken RJ, 'The roe of free oxygen radicals and sperm function', International Journal of Andrology, 12 95-97 (1989)

Despite the fact that defective sperm function is the largest defined cause of human infertility there are few, if any, effective treatments which address this condition. The major reason for this lack of therapeutic options, is our lack of knowledge concerning the precise biochemical nature of the lesions that are responsible for the loss of fertilizing potential. Without a knowledge of the mechanisms leading to defective sperm function, a rational approach towards the development of appropriate therapies is clearly impossible. In this context, evidence for at least one major cause of sperm dysfunction has come from a number of recent studies suggesting a possible role for lipid peroxidation in the loss of functional competence. This concept was originally put forward by Jones & Mann 1973; Jones, Mann & Sherins, 1978;1979) and has since been supported by studies focusing on the capacity of human sperm to generate the reactive oxygen species which initiate the peroxidation process (Aitken & Clarkson, 1987; Alvarez et al., 1987).

CitationsScopus - 57
1989WHITE DR, AITKEN RJ, 'RELATIONSHIP BETWEEN CALCIUM, CYCLIC-AMP, ATP, AND INTRACELLULAR PH AND THE CAPACITY OF HAMSTER SPERMATOZOA TO EXPRESS HYPERACTIVATED MOTILITY', GAMETE RESEARCH, 22 163-177 (1989)
DOI10.1002/mrd.1120220205Author URL
CitationsScopus - 130Web of Science - 154
1989RATNASOORIYA WD, AITKEN RJ, 'TRANSMEMBRANE MIGRATION TECHNIQUE - REEXAMINATION OF ITS USEFULNESS IN SPERM MOTILITY ASSESSMENTS', JOURNAL OF PHARMACOLOGICAL METHODS, 22 259-264 (1989)
DOI10.1016/0160-5402(89)90005-3Author URL
CitationsWeb of Science - 3
1989AITKEN RJ, CLARKSON JS, HARGREAVE TB, IRVINE DS, WU FCW, 'ANALYSIS OF THE RELATIONSHIP BETWEEN DEFECTIVE SPERM FUNCTION AND THE GENERATION OF REACTIVE OXYGEN SPECIES IN CASES OF OLIGOZOOSPERMIA', JOURNAL OF ANDROLOGY, 10 214-220 (1989)
Author URL
CitationsScopus - 167Web of Science - 213
1989West JD, West KM, Aitken RJ, 'Detection of Y-bearing spermatozoa by DNA-DNA in situ hybridisation', Molecular Reproduction and Development, 1 201-207 (1989)
CitationsScopus - 8
1989Braude P, Johnson MH, Aitken RJ, 'Positive benefits of IVF', Lancet, 1328-1329 (1989)
1988AITKEN RJ, PARSLOW JM, HARGREAVE TB, HENDRY WF, 'INFLUENCE OF ANTISPERM ANTIBODIES ON HUMAN-SPERM FUNCTION', BRITISH JOURNAL OF UROLOGY, 62 367-373 (1988)
DOI10.1111/j.1464-410X.1988.tb04367.xAuthor URL
CitationsScopus - 38Web of Science - 54
1988HARGREAVE TB, AITKEN RJ, ELTON RA, 'PROGNOSTIC-SIGNIFICANCE OF THE ZONA-FREE HAMSTER EGG TEST', BRITISH JOURNAL OF UROLOGY, 62 603-608 (1988)
DOI10.1111/j.1464-410X.1988.tb04436.xAuthor URL
CitationsWeb of Science - 4
1988AITKEN RJ, ELTON RA, 'POISSON-DISTRIBUTION OF SPERM AMONG OVA', FERTILITY AND STERILITY, 50 182-182 (1988)
Author URL
1988HENDERSON CJ, HULME MJ, AITKEN RJ, 'CONTRACEPTIVE POTENTIAL OF ANTIBODIES TO THE ZONA PELLUCIDA', JOURNAL OF REPRODUCTION AND FERTILITY, 83 325-343 (1988)
Author URL
CitationsScopus - 28Web of Science - 62
1988AITKEN RJ, PATERSON M, 'NEW HORIZONS IN CONTRACEPTION', NATURE, 335 492-493 (1988)
DOI10.1038/335492a0Author URL
CitationsWeb of Science - 4
1988AITKEN RJ, CLARKSON JS, HULME MJ, HENDERSON CJ, 'ANALYSIS OF CALMODULIN ACCEPTOR PROTEINS AND THE INFLUENCE OF CALMODULIN ANTAGONISTS ON HUMAN-SPERMATOZOA', GAMETE RESEARCH, 21 93-111 (1988)
DOI10.1002/mrd.1120210111Author URL
CitationsScopus - 15Web of Science - 35
1988AITKEN RJ, CLARKSON JS, 'SIGNIFICANCE OF REACTIVE OXYGEN SPECIES AND ANTIOXIDANTS IN DEFINING THE EFFICACY OF SPERM PREPARATION TECHNIQUES', JOURNAL OF ANDROLOGY, 9 367-376 (1988)
Author URL
CitationsScopus - 350Web of Science - 409
1988AITKEN RJ, 'ASSESSMENT OF SPERM FUNCTION FOR IVF', HUMAN REPRODUCTION, 3 89-95 (1988)
Author URL
CitationsScopus - 22Web of Science - 50
1987AITKEN RJ, HULME MJ, HENDERSON CJ, HARGREAVE TB, ROSS A, 'ANALYSIS OF THE SURFACE LABELING CHARACTERISTICS OF HUMAN-SPERMATOZOA AND THE INTERACTION WITH ANTISPERM ANTIBODIES', JOURNAL OF REPRODUCTION AND FERTILITY, 80 473-485 (1987)
Author URL
CitationsScopus - 22Web of Science - 35
1987AITKEN RJ, CLARKSON JS, 'CELLULAR BASIS OF DEFECTIVE SPERM FUNCTION AND ITS ASSOCIATION WITH THE GENESIS OF REACTIVE OXYGEN SPECIES BY HUMAN-SPERMATOZOA', JOURNAL OF REPRODUCTION AND FERTILITY, 81 459-469 (1987)
Author URL
CitationsScopus - 520Web of Science - 581
1987AITKEN RJ, 'SPERM SEPARATION TECHNIQUES', INTERNATIONAL JOURNAL OF ANDROLOGY, 10 643-645 (1987)
Author URL
CitationsWeb of Science - 4
1987HENDERSON CJ, HULME MJ, AITKEN RJ, 'ANALYSIS OF THE BIOLOGICAL PROPERTIES OF ANTIBODIES RAISED AGAINST INTACT AND DEGLYCOSYLATED PORCINE ZONAE PELLUCIDAE', GAMETE RESEARCH, 16 323-341 (1987)
DOI10.1002/mrd.1120160407Author URL
CitationsScopus - 20Web of Science - 43
1987HENDERSON CJ, BRAUDE P, AITKEN RJ, 'POLYCLONAL ANTIBODIES TO A 32-KDA DEGLYCOSYLATED POLYPEPTIDE FROM PORCINE ZONAE PELLUCIDAE WILL PREVENT HUMAN GAMETE INTERACTION INVITRO', GAMETE RESEARCH, 18 251-265 (1987)
DOI10.1002/mrd.1120180306Author URL
CitationsScopus - 11Web of Science - 26
1987AITKEN RJ, THATCHER S, GLASIER AF, CLARKSON JS, WU FCW, BAIRD DT, 'RELATIVE ABILITY OF MODIFIED VERSIONS OF THE HAMSTER OOCYTE PENETRATION TEST, INCORPORATING HYPEROSMOTIC MEDIUM OR THE IONOPHORE A23187, TO PREDICT IVF OUTCOME', HUMAN REPRODUCTION, 2 227-231 (1987)
Author URL
CitationsScopus - 25Web of Science - 57
1987Irvine DS, Aitken RJ, 'Predictive value of in vitro sperm function tests in the context of an AID service', Human Reproduction, 539-545 (1987)
1986AITKEN RJ, 'DIAGNOSIS OF HUMAN-SPERM FUNCTION', DEVELOPMENT GROWTH & DIFFERENTIATION, 28 9-10 (1986)
Author URL
CitationsWeb of Science - 1
1986TEMPLETON AA, VANLOOK P, ANGELL RE, AITKEN RJ, LUMSDEN MA, BAIRD DT, 'OOCYTE RECOVERY AND FERTILIZATION RATES IN WOMEN AT VARIOUS TIMES AFTER THE ADMINISTRATION OF HCG', JOURNAL OF REPRODUCTION AND FERTILITY, 76 771-778 (1986)
Author URL
CitationsScopus - 14Web of Science - 18
1986AITKEN RJ, ELTON RA, 'APPLICATION OF POISSON-DISTRIBUTION THEORY TO THE ZONA-FREE HAMSTER OOCYTE PENETRATION TEST TO ASSESS SPERM FUNCTION OF MEN WITH ASTHENOZOOSPERMIA', JOURNAL OF REPRODUCTION AND FERTILITY, 77 67-74 (1986)
Author URL
CitationsWeb of Science - 7
1986AITKEN RJ, IRVINE S, KELLY RW, 'SIGNIFICANCE OF INTRACELLULAR CALCIUM AND CYCLIC ADENOSINE-3',5'-MONOPHOSPHATE IN THE MECHANISMS BY WHICH PROSTAGLANDINS INFLUENCE HUMAN-SPERM FUNCTION', JOURNAL OF REPRODUCTION AND FERTILITY, 77 451-462 (1986)
Author URL
CitationsScopus - 18Web of Science - 26
1986AITKEN RJ, MATTEI A, IRVINE S, 'PARADOXICAL STIMULATION OF HUMAN-SPERM MOTILITY BY 2-DEOXYADENOSINE', JOURNAL OF REPRODUCTION AND FERTILITY, 78 515-527 (1986)
Author URL
CitationsScopus - 33Web of Science - 70
1986AITKEN RJ, ELTON RA, 'APPLICATION OF A POISSON-GAMMA-MODEL TO STUDY THE INFLUENCE OF GAMETE CONCENTRATION ON SPERM-OOCYTE FUSION IN THE ZONA-FREE HAMSTER EGG PENETRATION TEST', JOURNAL OF REPRODUCTION AND FERTILITY, 78 733-739 (1986)
Author URL
CitationsScopus - 2Web of Science - 9
1986AITKEN RJ, WAITES GMH, 'THE ZONA-FREE HAMSTER OOCYTE PENETRATION TEST AND THE DIAGNOSIS OF MALE-FERTILITY - PROCEEDINGS OF A WORKSHOP HELD IN BOSTON, MAY 3 1985 - PREFACE', INTERNATIONAL JOURNAL OF ANDROLOGY, 9-9 (1986)
Author URL
1986AITKEN RJ, ELTON RA, 'QUANTITATIVE-ANALYSIS OF SPERM-EGG INTERACTION IN THE ZONA-FREE HAMSTER EGG PENETRATION TEST', INTERNATIONAL JOURNAL OF ANDROLOGY, 14-30 (1986)
Author URL
CitationsScopus - 1
1986IRVINE DS, AITKEN RJ, 'CLINICAL-EVALUATION OF THE ZONA-FREE HAMSTER EGG PENETRATION TEST IN THE MANAGEMENT OF THE INFERTILE COUPLE - PROSPECTIVE AND RETROSPECTIVE STUDIES', INTERNATIONAL JOURNAL OF ANDROLOGY, 97-112 (1986)
Author URL
1986WOLF DP, AITKEN RJ, ALEXANDER N, BARROS C, BLAQUIER JA, COMHAIRE F, et al., 'THE ZONA-FREE HAMSTER OOCYTE PENETRATION TEST AND THE DIAGNOSIS OF MALE-FERTILITY - PROCEEDINGS OF A WORKSHOP HELD IN BOSTON, MAY 3 1985 - GROUP DISCUSSION', INTERNATIONAL JOURNAL OF ANDROLOGY, 145-199 (1986)
Author URL
1986unknown, 'The zona-free hamster oocyte penetration test and the diagnosis of male fertility', International Journal of Andrology, Supplement, 0-0 (1986)
1986IRVINE DS, AITKEN RJ, LEES MM, REID C, 'FAILURE OF HIGH INTRAUTERINE INSEMINATION OF HUSBANDS SEMEN', LANCET, 2 972-973 (1986)
Author URL
CitationsScopus - 8Web of Science - 19
1986IRVINE DS, AITKEN RJ, 'MEASUREMENT OF INTRACELLULAR CALCIUM IN HUMAN-SPERMATOZOA', GAMETE RESEARCH, 15 57-71 (1986)
DOI10.1002/mrd.1120150107Author URL
CitationsScopus - 16Web of Science - 35
1986AITKEN RJ, WARNER PE, REID C, 'FACTORS INFLUENCING THE SUCCESS OF SPERM CERVICAL-MUCUS INTERACTION IN PATIENTS EXHIBITING UNEXPLAINED INFERTILITY', JOURNAL OF ANDROLOGY, 7 3-10 (1986)
Author URL
CitationsScopus - 20Web of Science - 37
1986IRVINE DS, AITKEN RJ, 'PREDICTIVE VALUE OF INVITRO SPERM FUNCTION-TESTS IN THE CONTEXT OF AN AID SERVICE', HUMAN REPRODUCTION, 1 539-545 (1986)
Author URL
CitationsScopus - 33Web of Science - 56
1986Messinis IE, Templeton A, Angell R, Aitken RJ, 'A comparison of fixed regimes for obtaining human cleaving oocytes for research purposes', British Journal of Obstetrics and Gynaecology, 39-42 (1986)
1986ANGELL RR, TEMPLETON AA, AITKEN RJ, 'CHROMOSOME-STUDIES IN HUMAN INVITRO FERTILIZATION', HUMAN GENETICS, 72 333-339 (1986)
DOI10.1007/BF00290960Author URL
CitationsScopus - 36Web of Science - 69
1986unknown, 'The zona-free hamster oocyte penetration test and the diagnosis of male fertility', International Journal of Andrology, Supplement, 0-0 (1986)
1985IRVINE DS, AITKEN RJ, 'THE VALUE OF ADENOSINE-TRIPHOSPHATE (ATP) MEASUREMENTS IN ASSESSING THE FERTILIZING ABILITY OF HUMAN-SPERMATOZOA', FERTILITY AND STERILITY, 44 806-813 (1985)
Author URL
CitationsScopus - 11Web of Science - 39
1985AITKEN RJ, KELLY RW, 'ANALYSIS OF THE DIRECT EFFECTS OF PROSTAGLANDINS ON HUMAN-SPERM FUNCTION', JOURNAL OF REPRODUCTION AND FERTILITY, 73 139-146 (1985)
Author URL
CitationsScopus - 46Web of Science - 64
1985AITKEN RJ, SUTTON M, WARNER P, RICHARDSON DW, 'RELATIONSHIP BETWEEN THE MOVEMENT CHARACTERISTICS OF HUMAN-SPERMATOZOA AND THEIR ABILITY TO PENETRATE CERVICAL-MUCUS AND ZONA-FREE HAMSTER OOCYTES', JOURNAL OF REPRODUCTION AND FERTILITY, 73 441-449 (1985)
Author URL
CitationsScopus - 70Web of Science - 120
1985AITKEN RJ, 'DIAGNOSTIC-VALUE OF THE ZONA-FREE HAMSTER OOCYTE PENETRATION TEST AND SPERM MOVEMENT CHARACTERISTICS IN OLIGOZOOSPERMIA', INTERNATIONAL JOURNAL OF ANDROLOGY, 8 348-356 (1985)
DOI10.1111/j.1365-2605.1985.tb00847.xAuthor URL
CitationsScopus - 12Web of Science - 28
1985Aitken RJ, Clarkson JS, Irvine DS, Richardson DW, 'Contribution of defective sperm function to infertility', Acta Europaea Fertilitatis, 16 273-280 (1985)

The nature of significance of some biologically orientated tests of human sperm function is discussed by the authors. In particular tests for motility and the fertilizing capacity of spermatozoa are examined, motility tests and the zona-free hamster oocyte penetration test are particularly criticized. The authors affirm that hamster oocyte tests carried out in the presence of A 23187 have shown to correlate with fertility in vivo and may be of critical value in decreasing the incidence of false negative scores. The data furnished by this test will provide a logical basis for discovering the etiology of male infertility as well as devising techniques to both detect and treat these conditions.

CitationsScopus - 1
1985Westergaard L, Byskov AG, Van Look PFA, Angell R, Aitken RJ, 'Meiosis inducing substances in human preovulatory follicular fluid related to time of follicle aspiration and to the potential of the oocyte to fertilize and cleave in vitro', Fertility and Sterility, 663-667 (1985)
1984AITKEN RJ, BEST FSM, WARNER P, TEMPLETON A, 'A PROSPECTIVE-STUDY OF THE RELATIONSHIP BETWEEN SEMEN QUALITY AND FERTILITY IN CASES OF UNEXPLAINED INFERTILITY', JOURNAL OF ANDROLOGY, 5 297-303 (1984)
Author URL
CitationsWeb of Science - 104
1984AITKEN RJ, ROSS A, HARGREAVE T, RICHARDSON D, BEST F, 'ANALYSIS OF HUMAN-SPERM FUNCTION FOLLOWING EXPOSURE TO THE IONOPHORE-A23187 - COMPARISON OF NORMOSPERMIC AND OLIGOZOOSPERMIC MEN', JOURNAL OF ANDROLOGY, 5 321-329 (1984)
Author URL
CitationsWeb of Science - 137
1984SCHATS R, AITKEN RJ, TEMPLETON AA, DJAHANBAKHCH O, 'THE ROLE OF CERVICAL-MUCUS SEMEN INTERACTION IN INFERTILITY OF UNKNOWN ETIOLOGY', BRITISH JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 91 371-376 (1984)
DOI10.1111/j.1471-0528.1984.tb05926.xAuthor URL
CitationsScopus - 12Web of Science - 50
1984Aitken RJ, 'In vitro fertilization for male infertility', Acta Europaea Fertilitatis, 15 425-429 (1984)
CitationsScopus - 1
1984AITKEN RJ, 'CLINICAL-ASSESSMENT OF HUMAN-SPERM FUNCTION', CONTRACEPTION FERTILITE SEXUALITE, 12 33-37 (1984)
Author URL
CitationsWeb of Science - 1
1984Aitken RJ, 'Clinical assessment of human sperm function', Contraception Fertilite Sexualite, 12 33-37 (1984)
1984RICHARDSON DW, AITKEN RJ, LOUDON NB, 'THE FUNCTIONAL COMPETENCE OF HUMAN-SPERMATOZOA RECOVERED AFTER VASECTOMY', JOURNAL OF REPRODUCTION AND FERTILITY, 70 575-579 (1984)
Author URL
CitationsScopus - 16Web of Science - 19
1984AITKEN RJ, ELTON RA, 'SIGNIFICANCE OF POISSON-DISTRIBUTION THEORY IN ANALYZING THE INTERACTION BETWEEN HUMAN-SPERMATOZOA AND ZONA-FREE HAMSTER OOCYTES', JOURNAL OF REPRODUCTION AND FERTILITY, 72 311-321 (1984)
Author URL
CitationsScopus - 6Web of Science - 39
1984AITKEN RJ, 'DIAGNOSTIC-VALUE OF THE HAMSTER OOCYTE PENETRATION ASSAY', INTERNATIONAL JOURNAL OF ANDROLOGY, 7 273-275 (1984)
Author URL
CitationsScopus - 2Web of Science - 5
1984TEMPLETON AA, GLASIER A, ANGELL RR, AITKEN RJ, 'WHAT POTENTIAL OVUM DONORS THINK', LANCET, 1 1081-1082 (1984)
Author URL
CitationsScopus - 4Web of Science - 6
1983AITKEN RJ, ROSS A, LEES MM, 'ANALYSIS OF SPERM FUNCTION IN KARTAGENERS SYNDROME', FERTILITY AND STERILITY, 40 696-698 (1983)
Author URL
CitationsScopus - 10Web of Science - 58
1983AITKEN RJ, BEST F, RICHARDSON DW, SCHATS R, SIMM G, 'INFLUENCE OF CAFFEINE ON MOVEMENT CHARACTERISTICS, FERTILIZING-CAPACITY AND ABILITY TO PENETRATE CERVICAL-MUCUS OF HUMAN-SPERMATOZOA', JOURNAL OF REPRODUCTION AND FERTILITY, 67 19-27 (1983)
Author URL
CitationsScopus - 28Web of Science - 69
1983KHOLKUTE SD, AITKEN RJ, LUNN SF, 'PLASMA TESTOSTERONE RESPONSE TO HCG STIMULATION IN THE MALE MARMOSET MONKEY (CALLITHRIX-JACCHUS-JACCHUS)', JOURNAL OF REPRODUCTION AND FERTILITY, 67 457-463 (1983)
Author URL
CitationsScopus - 5Web of Science - 8
1983ANGELL RR, AITKEN RJ, VANLOOK PFA, LUMSDEN MA, TEMPLETON AA, 'CHROMOSOME-ABNORMALITIES IN HUMAN-EMBRYOS AFTER INVITRO FERTILIZATION', NATURE, 303 336-338 (1983)
DOI10.1038/303336a0Author URL
CitationsScopus - 45Web of Science - 125
1983AITKEN RJ, 'REPRODUCTIVE PHYSIOLOGY OF VERTEBRATES, 2ND EDITION - VANTEINHOVEN,A', NATURE, 305 165-166 (1983)
DOI10.1038/305165b0Author URL
1983AITKEN RJ, LIU J, BEST FSM, RICHARDSON DW, 'AN ANALYSIS OF THE DIRECT EFFECTS OF GOSSYPOL ON HUMAN-SPERMATOZOA', INTERNATIONAL JOURNAL OF ANDROLOGY, 6 157-167 (1983)
DOI10.1111/j.1365-2605.1983.tb00334.xAuthor URL
CitationsWeb of Science - 30
1983AITKEN RJ, WANG YF, LIU J, BEST F, RICHARDSON DW, 'THE INFLUENCE OF MEDIUM COMPOSITION, OSMOLARITY AND ALBUMIN CONTENT ON THE ACROSOME REACTION AND FERTILIZING-CAPACITY OF HUMAN-SPERMATOZOA - DEVELOPMENT OF AN IMPROVED ZONA-FREE HAMSTER EGG PENETRATION TEST', INTERNATIONAL JOURNAL OF ANDROLOGY, 6 180-193 (1983)
DOI10.1111/j.1365-2605.1983.tb00337.xAuthor URL
CitationsScopus - 14Web of Science - 77
1983AITKEN RJ, WARNER P, BEST FSM, TEMPLETON AA, DJAHANBAKHCH O, MORTIMER D, LEES MM, 'THE PREDICTABILITY OF SUBNORMAL PENETRATING CAPACITY OF SPERM IN CASES OF UNEXPLAINED INFERTILITY', INTERNATIONAL JOURNAL OF ANDROLOGY, 6 212-220 (1983)
DOI10.1111/j.1365-2605.1983.tb00534.xAuthor URL
CitationsScopus - 4Web of Science - 26
1983Aitken RJ, Liu J, Best FSM, Richardson DW, 'An analysis of gossypol on human spermatoza', International Journal of Andrology, 6 157-167 (1983)

The direct effects of gossypol and its acetic acid adduct, on the movement and functional competence of human spermatozoa were investigated employing exposure times of 1, 5 or 15 min and concentrations of 50µm, 500µm and 100µm. These compounds markedly reduced the motility, velocity, frequency of sperm head rotation and linearity of sperm progression, the most significant effects being observed with gossypol acetic acid on populations of 'capacitated' spermatozoa. Significant direct effects of gossypol on the ability of human spermatozoa to penetrate both cervival mucus and zona-free hamster ova were also observed, which were independent of any effects on motility. These results reinforce the notion that gossypol may serve a contraceptive role in the female as a 'spermicidal' agent, and suggest that this compound may also be of scientific value as a probe for identifying and isolating functionally important components of the human spermatozoon.

CitationsScopus - 14
1983AITKEN RJ, 'CLINICAL-ASSESSMENT OF HUMAN-SPERM FUNCTION', JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 3 S48-S52 (1983)
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CitationsScopus - 2Web of Science - 2
1982AITKEN RJ, BEST FSM, RICHARDSON DW, DJAHANBAKHCH O, LEES MM, 'THE CORRELATES OF FERTILIZING-CAPACITY IN NORMAL FERTILE MEN', FERTILITY AND STERILITY, 38 68-76 (1982)
Author URL
CitationsScopus - 27Web of Science - 138
1982AITKEN RJ, BEST FSM, RICHARDSON DW, DJAHANBAKHCH O, MORTIMER D, TEMPLETON AA, LEES MM, 'AN ANALYSIS OF SPERM FUNCTION IN CASES OF UNEXPLAINED INFERTILITY - CONVENTIONAL CRITERIA, MOVEMENT CHARACTERISTICS, AND FERTILIZING-CAPACITY', FERTILITY AND STERILITY, 38 212-221 (1982)
Author URL
CitationsScopus - 69Web of Science - 178
1982AITKEN RJ, BEST FSM, RICHARDSON DW, DJAHANBAKHCH O, TEMPLETON A, LEES MM, 'AN ANALYSIS OF SEMEN QUALITY AND SPERM FUNCTION IN CASES OF OLIGOZOOSPERMIA', FERTILITY AND STERILITY, 38 705-711 (1982)
Author URL
CitationsScopus - 16Web of Science - 55
1982AITKEN RJ, HOLME E, RICHARDSON DW, HULME M, 'PROPERTIES OF INTACT AND UNIVALENT (FAB) ANTIBODIES RAISED AGAINST ISOLATED, SOLUBILIZED, MOUSE ZONAE PELLUCIDAE', JOURNAL OF REPRODUCTION AND FERTILITY, 66 327-334 (1982)
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CitationsScopus - 12Web of Science - 23
1982HARDING RD, HULME MJ, LUNN SF, HENDERSON C, AITKEN RJ, 'PLASMA PROGESTERONE LEVELS THROUGHOUT THE OVARIAN CYCLE OF THE COMMON MARMOSET (CALLITHRIX-JACCHUS)', JOURNAL OF MEDICAL PRIMATOLOGY, 11 43-51 (1982)
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CitationsScopus - 20Web of Science - 45
1982HULME MJ, AITKEN RJ, RICHARDSON DW, 'USE OF A RADIOIMMUNOASSAY TECHNIQUE TO MEASURE THE TITER OF ANTI-COW-ZONA ANTIBODIES IN MARMOSET MONKEYS', GAMETE RESEARCH, 5 271-281 (1982)
DOI10.1002/mrd.1120050307Author URL
CitationsWeb of Science - 6
1982Templeton AA, Aitken RJ, Mortimer D, Best F, 'Sperm function in patients with unexplained infertility', British Journal of Obstetrics and Gynaecology, 550-554 (1982)
1982Aitken RJ, 'A review of the development and function of reproductive organs', Biochemical Transactions, 2 (1982)
1982Aitken RJ, 'Family Planning II. Research and development in contraception', Journal of Postgraduate General Practice, 211-216 (1982)
1982Aitken RJ, 'Seminal secrets', Nature, 633-643 (1982)
1982Aitken RJ, Chisholm GD, 'The ascent of andrology', Nature, 499-499 (1982)
1981DOR J, RUDAK E, AITKEN RJ, 'ANTISPERM ANTIBODIES - THEIR EFFECT ON THE PROCESS OF FERTILIZATION STUDIED INVITRO', FERTILITY AND STERILITY, 35 535-541 (1981)
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CitationsScopus - 10Web of Science - 60
1981RUDAK E, DOR J, AITKEN RJ, DJAHANBAKHCH O, BOWMAN P, WEISSENBERG R, et al., 'CONTRIBUTION OF ABNORMAL SPERM FUNCTION TO THE ETIOLOGY OF UNEXPLAINED INFERTILITY, AS DIAGNOSED BY THE ZONA-FREE HAMSTER EGG PENETRATION TEST', ISRAEL JOURNAL OF MEDICAL SCIENCES, 17 780-780 (1981)
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1981DOR J, RUDAK E, AITKEN RJ, 'INHIBITORY EFFECT OF ANTI-SPERM ANTIBODIES ON THE FERTILIZING-CAPACITY OF HUMAN-SPERMATOZOA STUDIED INVITRO', ISRAEL JOURNAL OF MEDICAL SCIENCES, 17 780-781 (1981)
Author URL
1981AITKEN RJ, RICHARDSON DW, 'ACTIVE IMMUNIZATION OF RATS WITH CUMULUS-FREE MOUSE OVA - INDUCTION OF INFERTILITY AND ANTIBODY-TITERS', JOURNAL OF EXPERIMENTAL ZOOLOGY, 216 149-158 (1981)
DOI10.1002/jez.1402160116Author URL
CitationsWeb of Science - 10
1981COOPER DW, AITKEN RJ, 'FAILURE TO DETECT ALTERED ROSETTE INHIBITION TITERS IN HUMAN-PREGNANCY SERUM', JOURNAL OF REPRODUCTION AND FERTILITY, 61 241-245 (1981)
Author URL
CitationsScopus - 9Web of Science - 24
1981AITKEN RJ, RUDAK EA, RICHARDSON DW, DOR J, DJAHANBAHKCH O, TEMPLETON AA, 'THE INFLUENCE OF ANTI-ZONA AND ANTI-SPERM ANTIBODIES ON SPERM-EGG INTERACTIONS', JOURNAL OF REPRODUCTION AND FERTILITY, 62 597-& (1981)
Author URL
CitationsScopus - 4Web of Science - 25
1981AITKEN RJ, RICHARDSON DW, 'MEASUREMENT OF THE SPERM BINDING-CAPACITY OF THE MOUSE ZONA PELLUCIDA AND ITS USE IN THE ESTIMATION OF ANTI-ZONA ANTIBODY-TITERS', JOURNAL OF REPRODUCTION AND FERTILITY, 63 295-& (1981)
Author URL
CitationsScopus - 4Web of Science - 11
1981AITKEN RJ, RICHARDSON DW, 'MECHANISM OF SPERM-BINDING INHIBITION BY ANTI-ZONA ANTISERA', GAMETE RESEARCH, 4 41-47 (1981)
DOI10.1002/mrd.1120040107Author URL
CitationsScopus - 4Web of Science - 17
1981CANIVENC R, MAUGET C, BONNIN M, AITKEN RJ, 'DELAYED IMPLANTATION IN THE BEECH MARTEN (MARTES-FOINA)', JOURNAL OF ZOOLOGY, 193 325-332 (1981)
Author URL
CitationsWeb of Science - 7
1981Aitken RJ, 'Aspects of delayed implantation in the roe deer (Capreolus capreolus)', Journal of Reproduction and Fertility Supplement, 83-95 (1981)
1981Aitken RJ, 'A review of gamete research, archives of andrology and reproduction', Nature, 345 (1981)
1980DJAHANBAKHCH O, MCNEILLY AS, HOBSON BM, AITKEN RJ, 'APPLICATION OF RAPID LH RADIOIMMUNOASSAY FOR PREDICTION OF OVULATION', ARCHIVES OF ANDROLOGY, 5 19-19 (1980)
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CitationsWeb of Science - 1
1979AITKEN RJ, 'CONTRACEPTIVE RESEARCH AND DEVELOPMENT', BRITISH MEDICAL BULLETIN, 35 199-& (1979)
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CitationsScopus - 4Web of Science - 7
1979AITKEN RJ, 'TUBAL AND UTERINE SECRETIONS - POSSIBILITIES FOR CONTRACEPTIVE ATTACK', JOURNAL OF REPRODUCTION AND FERTILITY, 55 247-& (1979)
Author URL
CitationsWeb of Science - 23
1978MAATHUIS JB, AITKEN RJ, 'CYCLIC VARIATION IN CONCENTRATIONS OF PROTEIN AND HEXOSE IN HUMAN UTERINE FLUSHINGS COLLECTED BY AN IMPROVED TECHNIQUE', JOURNAL OF REPRODUCTION AND FERTILITY, 52 289-295 (1978)
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CitationsScopus - 5Web of Science - 14
1978AITKEN RJ, MAATHUIS JB, 'EFFECT OF HUMAN UTERINE FLUSHINGS COLLECTED AT VARIOUS STAGES OF MENSTRUAL-CYCLE ON MOUSE BLASTOCYSTS INVITRO', JOURNAL OF REPRODUCTION AND FERTILITY, 53 137-140 (1978)
Author URL
CitationsScopus - 4Web of Science - 7
1978MAATHUIS JB, AITKEN RJ, 'PROTEIN PATTERNS OF HUMAN UTERINE FLUSHINGS COLLECTED AT VARIOUS STAGES OF MENSTRUAL-CYCLE', JOURNAL OF REPRODUCTION AND FERTILITY, 53 343-& (1978)
Author URL
CitationsScopus - 9Web of Science - 17
1977AITKEN RJ, CARTER J, 'BEHAVIORAL CONSEQUENCES OF VASECTOMY IN MOUSE', EXPERIENTIA, 33 1396-1397 (1977)
DOI10.1007/BF01920203Author URL
CitationsScopus - 1Web of Science - 2
1977AITKEN RJ, BOWMAN P, GAULD I, 'EFFECT OF SYNCHRONOUS AND ASYNCHRONOUS EGG TRANSFER ON FETAL WEIGHT IN MICE SELECTED FOR LARGE AND SMALL BODY SIZE', JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY, 37 59-64 (1977)
Author URL
CitationsScopus - 6Web of Science - 16
1977AITKEN RJ, 'CULTURE OF MOUSE BLASTOCYSTS IN PRESENCE OF UTERINE FLUSHINGS COLLECTED DURING NORMAL-PREGNANCY, DELAYED IMPLANTATION AND PRO-ESTRUS', JOURNAL OF EMBRYOLOGY AND EXPERIMENTAL MORPHOLOGY, 41 295-300 (1977)
Author URL
CitationsScopus - 3Web of Science - 12
1977AITKEN RJ, 'CHANGES IN PROTEIN-CONTENT OF MOUSE UTERINE FLUSHINGS DURING NORMAL-PREGNANCY AND DELAYED IMPLANTATION, AND AFTER OVARIECTOMY AND ESTRADIOL ADMINISTRATION', JOURNAL OF REPRODUCTION AND FERTILITY, 50 29-36 (1977)
Author URL
CitationsScopus - 18Web of Science - 59
1977AITKEN RJ, 'PROTEIN-CONTENT OF MOUSE UTERINE FLUSHINGS DURING PSEUDOPREGNANCY', JOURNAL OF REPRODUCTION AND FERTILITY, 50 191-& (1977)
Author URL
CitationsScopus - 2Web of Science - 11
1977AITKEN RJ, 'INFLUENCE OF ACTINOMYCIN-D ON PROTEIN-COMPOSITION OF MOUSE UTERINE FLUSHINGS', JOURNAL OF REPRODUCTION AND FERTILITY, 50 193-195 (1977)
Author URL
CitationsWeb of Science - 6
1977Aitken RJ, Harper MJK, 'New methods for the regulation of implantation', Contraception, 227-241 (1977)
1977Bonnin M, Canivenc R, Aitken RJ, 'Seasonal variations of plasma progesterone in the beech martin, Martes foina, a species which exhibits delayed implantation', C.R. Hebd Seanc. Acad Sci. Paris D, 1479-1482 (1977)
1976AITKEN RJ, 'UTERINE SECRETION OF FRUCTOSE IN ROE DEER', JOURNAL OF REPRODUCTION AND FERTILITY, 46 439-440 (1976)
Author URL
CitationsScopus - 3Web of Science - 11
1976Snow HML, Aitken RJ, Ansell J, 'The role of the inner cell mass in controlling ovo-implantation in the mouse', Journal of Reproduction and Fertility, 403-404 (1976)
1975AITKEN RJ, 'ULTRASTRUCTURE OF BLASTOCYST AND ENDOMETRIUM OF ROE DEER (CAPREOLUS-CAPREOLUS) DURING DELAYED IMPLANTATION', JOURNAL OF ANATOMY, 119 369-384 (1975)
Author URL
CitationsWeb of Science - 29
1975Aitken RJ, 'Ultrastructure of the blastocyst and endometrium of the roe deer (Capreolus capreolus) during delayed implantation', Journal of Anatomy, 119 369-384 (1975)

Transmission electron microscopy of the trophoblast cells during diapause revealed an abundance of electron dense, membrane bound granular inclusions and a marked lack of cytoplasmic organelles. The cells also possessed a well developed covering of branched microvilli, numerous caveolae, micropinocytotic vesicles and a lamina of fine fibrillae. The progressive enlargement of the blastocyst during diapause was correlated with a decline in the height of the trophoblast cells and a reduction in the density of microvilli and caveolae associated with the outer membrane. The granular inclusions also declined in number and electron density during the delay phase, suggesting the progressive utilisation of energy reserves. Embryonic elongation was associated with the disappearance of the granular inclusions, a reduction in the amount of fibrillar material and a dramatic increase in the development of cytoplasmic organelles. During diapause, clear vesicles, apparently derived from the Golgi apparatus, gradually accumulated in the supranuclear region of each gland and non ciliated duct cell. Embryonic elongation was associated with the sudden release of these vesicles into the glandular lumen and thence into the uterine lumen. Numerous apical protrusions were also observed projecting from the luminal and ductal epithelia at this time, suggesting the formation of an apocrine secretion. Another type of secretion was produced during the early stages of placental attachment by the hypertrophied granular endoplasmic reticulum of the ductal epithelium.

CitationsScopus - 9
1975AITKEN RJ, 'CEMENTUM LAYERS AND TOOTH WEAR AS CRITERIA FOR AGING ROE DEER (CAPREOLUS-CAPREOLUS)', JOURNAL OF ZOOLOGY, 175 15-28 (1975)
Author URL
CitationsWeb of Science - 39
1974Aitken RJ, 'Delayed implantation in roe deer (Capreolus capreolus)', Journal of Reproduction and Fertility, 39 225-233 (1974)

The results presented in this paper indicate that delayed implantation in the roe deer is due to a lack of certain factors which are needed to induce and support the process of embryonic growth. These factors are eventually supplied, in the first weeks of January, as a secretion emanating from the endometrial glands. This secretion contains uterine specific and serum proteins, about 20 free amino acids, protein bound glucose and galactose and, rather surprisingly, a free ketose which appears to be fructose. Elongation of the roe deer blastocyst is also correlated with a rise in the concentration of plasma estrogens, an endocrine change that may stimulate the endometrial glands into secretory activity. However, since simultaneous changes were not observed in the ovaries, the elevated estrogen levels may be a consequence rather than a cause of embryonic growth.

CitationsScopus - 36
1974Aitken RJ, 'Calcium and zinc in the endometrium and uterine flushings of the roe deer (Capreolus capreolus) during delayed implantation', Journal of Reproduction and Fertility, 40 333-340 (1974)

The concentration of zinc in the endometrium of the roe deer was maintained at a constantly high level throughout delayed implantation and at the time of rapid embryonic growth. By contrast, the zinc content of the uterine flushings was uniformly low and often undetectable (<0.1 µg/ml). The concentration of calcium in the endometrium showed a highly significant (P<0.001) increase during delayed implantation reaching maximal levels upon the resumption of rapid embryonic growth. The calcium content of the uterine flushings showed a small but significant (P<0.001) rise in the late stages of diapause followed by a further marked increase during the rapid elongation of the blastocyst in January.

CitationsScopus - 2
1974Aitken RJ, 'Sex chromatin formation in the blastocyst of the roe deer (Capreolus capreolus) during delayed implantation', Journal of Reproduction and Fertility, 40 235-239 (1974)

This study was based upon the analysis of thirty blastocysts and five elongating embryos flushed from the uteri of thirty roe deer. Whenever possible, the diameter of blastocysts was measured at the time of recovery, before they had started to collapse. The embryos were quickly removed from the flushing medium (0.85% phosphate-buffered saline), fixed in methanol and prepared as flat mounts for staining by the Feulgen or acetoorcein technique. The frequency of sex chromatin-positive cells was assessed by scoring at least 100 cells in each embryo; all observations were confined to the trophoblast since little nuclear detail could be distinguished within the inner cell mass of flat mount preparations. The results of this investigation revealed that the embryos could be divided into two distinct groups on the basis of nuclear morphology. In one group (the presumptive females) a large chromatin condensation resembling the sex chromatin body was observed in a majority of the trophectoderm, and some trophendoderm, cell nuclei. The sex chromatin was normally spherical, U-, or V-shaped and was located adjacent to the nuclear membrane, free in the nucleoplasm or in association with the nucleoli. The mean percentage frequency of sex chromatin-positive cells for all presumptive female embryos was 77.2 ± 8.3% (mean ± S.D.). If only those nuclei possessing a sex chromatin body adjacent to the nuclear membrane were scored as positive, the average frequency would have been about 51%. The roe deer seems to be similar to the rabbit and pig, therefore, in that sex chromatin formation occurs well before implantation. These preliminary results suggest a need for further studies to establish the time at which sex chromatin first appears in this species and its relation to the onset of embryonic diapause. The possibility also arises of using the roe deer blastocyst as a model for investigating the relationship between sex chromatin formation and changes in cell number, cell density and cell division, all of which show a gradual increase during the 5 months of delayed implantation.

1973Aitken RJ, Burton J, Hawkins J, Kerr-Wilson R, Short RV, Steven DH, 'Histological and ultrastructural changes in the blastocyst and reproductive tract of the roe deer, Capreolus capreolus, during delayed implantation', Journal of Reproduction and Fertility, 34 481-493 (1973)

The ultrastructure of 4 roe deer blastocysts at different stages of embryonic development were studied. During delayed implantation, the outer surface of the trophoblast possessed numerous microvilli and periodic invaginations or caveolae. There was a marked lack of organelles such as mitochondria or endoplasmic reticulum in the cytoplasm of the trophoblast cells, though many lipid droplets, granular inclusions and a lamina of fine fibrillae were present. Elongation of the blastocyst was associated with a decrease in the size and number of the microvilli, the disappearance of lipid droplets and granular inclusions, a reduction in the amount of fibrillar material and a dramatic increase in the development of mitochondria, granular endoplasmic reticulum, ribosomes and Golgi apparatus. The histology of the ovaries and uterus was studied in 31 roe deer. No prominent changes occurred in the ovaries at any stage of development; all ovaries possessed active CL and showed signs of follicular growth and atresia. Changes in the degree of mitotic activity, epithelial cell height, endometrial vascularity and stromal edema were observed in the uterus throughout the period of delayed implantation and during the phase of rapid embryonic growth. Elongation of the embryo was associated with a marked decline in the height of the glandular epithelium and an increase in endometrial vascularity. The most important ultrastructural changes in the uteri of 6 roe deer were observed in the endometrial glands. Delayed implantation was associated with the accumulation of numerous supranuclear vesicles derived from the Golgi apparatus, while the resumption of embryonic growth was correlated with their sudden disappearance. When elongation was completed, there was a sudden decrease in the cellular activity of these endometrial glands.

CitationsScopus - 16
1971Aitken RJ, Burton JHW, Steven DH, 'Ultrastructural changes in the uterine glands of the roe deer during delayed implantation', Journal of Physiology, 13-15 (1971)
Show 430 more journal articles

Review (1 outputs)

YearCitationAltmetricsLink
2007Nixon B, Aitken RJ, McLaughlin EA, 'New insights into the molecular mechanisms of sperm-egg interaction', CELLULAR AND MOLECULAR LIFE SCIENCES (2007) [D1]
DOI10.1007/s00018-007-6552-xAuthor URL
CitationsScopus - 61Web of Science - 59
Co-authorsBrett Nixon, Eileen Mclaughlin

Conference (129 outputs)

YearCitationAltmetricsLink
2014Aitken J, Clulow J, Freeman E, Metcalfe S, Fraser B, Clulow S, Mahony M, 'Biobanking spermatozoa to preserve endangered amphibian species.', 12th International Symposium on Spermatology, Newcastle, Australia (2014) [E3]
Co-authorsBrian Fraser, John Clulow, Simon Clulow
2014Lord T, Martin JH, Aitken RJ, 'ACCUMULATION OF 4-HYDROXYNONENAL DURING POST-OVULATORY AGEING OF MOUSE OOCYTES CAUSES REDUCED FERTILITY, OXIDATIVE STRESS AND APOPTOSIS.', FERTILITY AND STERILITY, Honolulu, HI (2014) [E3]
Author URL
2013Aitken RJ, Shokri S, Pujianto DA, Curry BJ, Whiting SJ, Salamonsen L, 'INSULIN AS AN IMPORTANT PROSURVIVAL FACTOR FOR HUMAN SPERMATOZOA', ANDROLOGY (2013) [E3]
Author URL
Co-authorsBen Curry
2013Baker M, Aitken J, 'ANALYSIS OF PHOSPHOPEPTIDE CHANGES AS SPERMATOZOA ACQUIRE FUNCTIONAL COMPETENCE IN THE EPIDIDYMIS DEMONSTRATES CHANGES IN THE POST-TRANSLATIONAL MODIFICATION OF IZUMO1', ANDROLOGY (2013) [E3]
Author URL
Co-authorsMark Baker
2012Maiti K, Gravina FS, Bowman M, Aitken RJ, Smith R, 'The ageing placenta and still birth', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012, Gold Coast, QLD (2012) [E3]
Co-authorsRoger Smith, Maria Bowman
2012Jobling MS, Aitken RJ, 'Oxidative stress and telomere length in human spermatozoa', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012, Gold Coast, QLD (2012) [E3]
2012Nixon B, Redgrove KA, Baker MA, Aitken RJ, 'The role of molecular chaperones in regulating human sperm-egg recognition', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012, Gold Coast, QLD (2012) [E3]
Co-authorsBrett Nixon, Mark Baker
2012Aitken RJ, Baker MA, 'Label-free proteomics as a tool for understanding the role of post-translational protein modifications in cell physiology: Insights into the regulation of sperm function.', Academic Journals, University of Western Cape, (2012) [E3]
2012Aitken RJ, 'Aetiology of defective sperm function and DNA damage in the male germ line', Journal of Reproductive Immunology, Hamburg, Germany (2012) [E3]
2012Shokri S, Aitken RJ, 'Prosurvival effects of insulin on human spermatozoa via stimulation of AKT phosphorylation, suppression of caspase activation and decreased mitochondrial ROS generation', HUMAN REPRODUCTION, Istanbul, TURKEY (2012) [E1]
Author URL
2012Aitken RJ, Nixon B, Redgrove KA, Dun M, Baker MA, 'The molecular origins of defective sperm function', HUMAN REPRODUCTION, Istanbul, TURKEY (2012) [E3]
Author URL
Co-authorsBrett Nixon, Matt Dun, Mark Baker
2012Kongmanas K, Sugeng C, Souda P, Faull K, Kitajima K, Aitken RJ, et al., 'Proteomic analysis of sperm anterior head plasma membrane: Unfolding the molecular components underlying sperm-egg interaction', Reproduction in Domestic Animals, Vancouver, Canada (2012) [E3]
Co-authorsMark Baker
2012Gibb Z, Lambourne SR, Aitken RJ, 'Do spermatozoa from fertile thoroughbred stallions live fast and die young?', Reproduction in Domestic Animals: Proceedings of the 17th International Congress on Animal Reproduction (ICAR), Vancouver, Canada (2012) [E3]
2011Dun MD, Aitken JR, Nixon B, 'The CCT/TRiC Complex Is Involved in Mediating Sperm-Oocyte Interaction', BIOLOGY OF REPRODUCTION, Portland, OR (2011) [E3]
Author URL
Co-authorsMatt Dun, Brett Nixon
2011Aitken RJ, Mitchell LA, Koppers A, Curry B, 'Sperm did a bad bad thing: Importance of pro-survival factors in preventing spermatozoa from defaulting to an apoptotic state', Journal of Andrology, Montreal (2011) [E3]
2010Aitken RJ, De Iuliis GN, 'Causes and consequences of DNA damage in spermatozoa.', ., Oknawa Japan (2010) [E2]
2010Koppers AJ, Mitchell LA, Pujianto DA, Aitken RJ, 'Evidence for a unique, truncated apoptotic pathway in human spermatozoa', Australian & New Zealand Journal of Obstetrics & Gynaecology, Adelaide, S.A. (2010) [E3]
2010Aitken RJ, 'Sperm biology for andrologists', International Journal of Andrology, Athens, Greece (2010) [E3]
2010Aitken RJ, 'Managing human population growth-utility of microbicides and spermicides', Journal of Reproductive Immunology, Palm Grove, QLD (2010) [E3]
2010Redgrove KA, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B, 'Identification and characterisation of surface protein complexes in human spermatozoa', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
Co-authorsBrett Nixon, Eileen Mclaughlin
2010Reid AT, Roman SD, Aitken RJ, Nixon B, 'Investigation of the role of dynamin in sperm surface remodelling', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
Co-authorsBrett Nixon, Shaun Roman
2010Aitken RJ, 'Origins of DNA Damage in Spermatazoa', Reproduction, Fertility and Development, Sydney (2010) [E3]
2010Redgrove KA, Nixon B, McLaughlin EA, O'Bryan MK, Aitken RJ, 'Identification and Characterisation of Surface Protein Complexes in Human Spermatozoa', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authorsBrett Nixon, Eileen Mclaughlin
2010Dun MD, Aitken RJ, Nixon B, 'The Chaperonin Containing TCP-1 (CCT/TRIC) Multisubunit Complex is Involved in Mediating Sperm-Oocyte Interactions', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authorsMatt Dun, Brett Nixon
2010Anderson AL, Mitchell LA, McLaughlin EA, O'Bryan MK, Aitken RJ, Nixon B, 'Proteomic and Functional Analysis of Human Sperm Detergent Resistant Membranes', Reproduction, Fertility and Development, Sydney (2010) [E3]
DOI10.1002/jcp.22615
Co-authorsEileen Mclaughlin, Brett Nixon
2010Tannock SJ, McLaughlin EA, Aitken RJ, Roman SD, 'SPIF - A Novel Testis-Specific Gene and its Interaction with PKA', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authorsEileen Mclaughlin, Shaun Roman
2010Reid AT, Roman SD, Aitken RJ, Nixon B, 'Characterisation of the GTPASE dynamin throughout murine sperm maturation', Reproduction, Fertility and Development, Sydney, NSW (2010) [E3]
Co-authorsBrett Nixon, Shaun Roman
2009Aitken RJ, 'The male factor in livestock reproduction', Livestock Reproduction - today and tomorrow, Gold Coast & Darwin (2009)
2009Aitken RJ, 'Early pregnancy loss', Livestock Reproduction - today and tomorrow, Gold Coast & Darwin (2009)
2009Aitken RJ, De Iuliis GN, Koppers AJ, 'OXIDATIVE STRESS AND SPERMATOZOA HEALTH', JOURNAL OF ANDROLOGY, Barcelona, SPAIN (2009) [E3]
Author URL
Co-authorsGeoffry DeiuliIs
2009de Iuliis GN, Newey RJ, King BV, Aitken RJ, 'MOBILE PHONE RADIATION INDUCES REACTIVE OXYGEN SPECIES PRODUCTION AND DNA DAMAGE IN HUMAN SPERMATOZOA IN VITRO', JOURNAL OF ANDROLOGY, Barcelona, SPAIN (2009) [E3]
Author URL
Co-authorsGeoffry DeiuliIs, Bruce King
2008De Iuliis GN, Nixon K, Aitken RJ, 'Estrogenic compounds induce oxidative stress in human spermatozoa: Implications for DNA integrity and fertilization success', Biology of Reproduction, Kailua-Kona, Hawaii (2008) [E3]
Co-authorsGeoffry DeiuliIs
2008Nixon B, Bielanowicz AJ, McLaughlin EA, Tanphaichitr N, Ensslin M, Aitken RJ, 'The composition and significance of lipid rafts in mouse spermatozoa', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction., Kailua-Kona, Hawaii (2008) [E3]
Co-authorsEileen Mclaughlin, Brett Nixon
2008Aitken RJ, De Iuliis GN, Nixon B, Roman SD, 'Causes and clinical significance of DNA damage in the male germ line', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction. "Reproductive Biology: Basic Discoveries that Affect Our Lives", Kailua-Kona, Hawaii (2008) [E3]
Co-authorsShaun Roman, Brett Nixon, Geoffry DeiuliIs
2008Baker MA, Hetherington L, Reeves GM, Smith ND, Aitken RJ, 'Comparative and phospho proteomics: Identification of protein changes during sperm maturation', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction. "Reproductive Biology: Basic Discoveries that Affect Our Lives", Kailua-Kona, Hawaii (2008) [E3]
Co-authorsMark Baker
2008Aitken R, Do Iuliis G, Nixon B, Roman S, 'Causes and clinical significance of DNA damage in the male germ line', BIOLOGY OF REPRODUCTION, Kona, HI (2008) [E3]
Author URL
Co-authorsShaun Roman, Brett Nixon
2008Mitchell LA, Nixon B, Aitken RJ, 'Investigation of the role of lipid rafts in human sperm-zona pellucida binding', Biology of Reproduction, Kailua-Kona, Hawaii (2008) [E3]
Co-authorsBrett Nixon
2007Hughes L, Wingate J, Griffith R, Aitken RJ, 'Modelling and measuring redox cycling and cytotoxicity of quinones.', Drug metabolism letters (2007) [E3]
DOI10.2174/187231207783221457
CitationsScopus - 1
Co-authorsScott Donne
2007Gunter KM, Fraser BA, Holt JE, Stanger SJ, Aitken RJ, Roman SD, McLaughlin EA, 'CXCR4/SDF1 interaction in the neonatal mouse testes', 7th Hunter Cellular Biology Meeting. Program, Hunter Valley, NSW (2007) [E3]
Co-authorsEileen Mclaughlin, Janet Holt, Shaun Roman
2007Schjenken JE, Stanger SJ, Smith V, Douglas A, De Iuliis GN, Depaz I, et al., 'Expression and activity of phase 1 detoxifying enzymes in the male sperm line of the mouse', 7th Hunter Cellular Biology Meeting. Program, Hunter Valley, NSW (2007) [E3]
Co-authorsBrett Nixon, Shaun Roman, Geoffry DeiuliIs
2007Koppers AJ, McLaughlin EA, Aitken RJ, 'Mitochondria are a significant source of reactive oxygen species in human spermatozoa', Combined Conference Abstracts - ComBio 2007 Conference, Sydney (2007) [E3]
Co-authorsEileen Mclaughlin
2007Aitken RJ, De Iuliis GN, 'Midnight's broken toll: The male germ cell and its role in the aetiology of genetic disease', Early Human Development, Perth, W.A. (2007) [E3]
Co-authorsGeoffry DeiuliIs
2007De Iuliis GN, Zelski K, Aitken RJ, 'The Impact of Estrogenic Compounds on DNA Integrity in the Male Germ Line', Endocrine Society of Australia (ESA) & Society for Reproductive Biology (SRB) Annual Scientific Meeting. Proceedings, Christchurch, New Zealand (2007) [E3]
Co-authorsGeoffry DeiuliIs
2007Aitken RJ, 'Proteomics in reproductive biology', Florence-Utah International Symposium: Genetics of Male Infertility. Program, Florence, Italy (2007) [E3]
2007Aitken RJ, 'The male contribution to infertility and genetic disease - From bad to worse?', Frontiers in Biomedical Research, HKU 2007, Hong Kong (2007) [E3]
2007Aitken RJ, 'Human spermatozoa: Imperfect beings in an imperfect world', Uroscience Forum. Program, Noosa, Qld (2007) [E3]
2007Fleming S, Ilad R, Ong K, Wu Y, Smith H, Aitken RJ, 'First prospective controlled trial of a novel membrane-based electrophoretic method of isolating spermatozoa for IVF', Australian & New Zealand Journal of Obstetrics & Gynaecology, Hobart, Tasmania (2007) [E3]
2006Baker MA, Reeves GM, Aitken RJ, 'New approaches towads the proteomic analysis of the human spermatozoon', JOURNAL OF ANDROLOGY, Chicago, IL (2006)
Author URL
Co-authorsMark Baker
2006Nixon B, Walsh A, Harman A, Aitken RJ, 'The role of molecular chaperones in sperm-oocyte interaction', JOURNAL OF ANDROLOGY, Chicago, IL (2006)
Author URL
Co-authorsBrett Nixon
2006Fraser BA, Holt JE, Andrew J, Roman SD, Stanger SJ, Aitken RJ, et al., 'CXCR4/SDF1 Interactionin the Embryonic and Neonatal Mpise Testes', Abstracts, Brisbane Convention Centre, QLD, Australia (2006) [E3]
Co-authorsEileen Mclaughlin, Shaun Roman, Janet Holt
2006McLaughlin EA, Dorey RA, Roman SD, Aitken RJ, 'Xenobiotis and Fertility: Expression Profiling of Defence Mechanisms Present in Murine Ovary', Abstract Book, Lorne, VIC, Australia (2006) [E3]
Co-authorsShaun Roman, Eileen Mclaughlin
2006Schjenken JE, Gilliam E, Borg Z, Aitken RJ, McLaughlin EA, Roman SD, 'Cytocrome P450 2E2 Mediates Acrylamide Damage to the Male Germ Line', Abstract Book, Lorne, VIC, Australia (2006) [E3]
Co-authorsShaun Roman, Eileen Mclaughlin
2006Aitken RJ, 'Advances in Sperm Cell Biology', Abstracts, Sheraton on the Park, Sydney (2006) [E3]
2006Aitken RJ, De Iuliis GN, 'Value of DNA integrity assays for fertility evaluation', Abstracts, Madrid, Spain (2006) [E3]
Co-authorsGeoffry DeiuliIs
2006Aitken RJ, 'Male infertility from bench to bedside', Abstracts, Kuala Lumpur, Malaysia (2006) [E3]
2006Aitken RJ, 'Novel therapies for the treatment of the infertile male', Abstracts, Kuala Lumpur, Malaysia (2006) [E3]
2006Aitken RJ, 'Impact of unsaturated fatty acids on human sperm function', Abstracts, Qwest Center Omaha, Omaha, Nebraska (2006) [E3]
Co-authorsEileen Mclaughlin
2006Aitken RJ, Baker MA, Lee YH, Lin M, Nixon B, 'Proteomic Changes in Mouse Spermatozoa During Epididymal Transit', Abstracts, Chatel-Guyon, Auvergne, France (2006) [E3]
Co-authorsMark Baker, Minjie Lin, Brett Nixon
2006Aitken RJ, 'The Y's and wherefores of male infertility', Book of Abstracts, Adelaide Convention Centre, Adelaide, SA (2006) [E3]
2006Aitken RJ, McLaughlin EA, 'Molecular mechanism in spem capacitation: progesterone induced secondary calcium oscillations reflect the attainment of a capacitated state', Book of Abstracts, New Delhi (2006) [E3]
Co-authorsEileen Mclaughlin
2006Baker MA, Reeves GE, Aitken RJ, 'New Approaches Towards the Proteomic Analysis of the Human Spermatozoon', Book of Abstracts, Lorne, Victoria, Australia (2006) [E3]
Co-authorsMark Baker
2006Paul JW, Aitken RJ, McLaughlin EA, 'Oolemmal Proteomics: Characterisation of Glycophosphatidylinositol Anchored Proteins Involved in Murine Fertilisation', Book of Abstracts, Lorne, Victoria, Australia (2006) [E3]
Co-authorsEileen Mclaughlin
2006Mitchell LA, Nixon B, Macintyre DA, Gibbs GM, O'Bryan M, Aitken RJ, 'The Role of Decapacitation Factors in the Regulation of Mouse Sperm Capacitation', Book of Abstracts, Lorne, Victoria, Australia (2006) [E3]
Co-authorsBrett Nixon
2006Nixon B, Paul JW, Spiller CM, Attwell-Heap AG, Aitken RJ, 'Evidence for the Involvement of Pecam-1 in a Reception Mediated Signal-Transduction Pathway regulating Capacitation-Associated Tyrosine Phosphorylation in Human Spermatozoa', Book of Abstracts, Lorne, Victoria, Australia (2006) [E3]
Co-authorsBrett Nixon
2006Walsh AK, Bielanowicz AJ, Mitchell LA, Spiller CM, Nixon B, Aitken RJ, 'Identification of a Metalloprotease, Adamts10, in Complex with Sperm Surface Molecular Chaperones', Book of Abstracts, Lorne, Victoria, Australia (2006) [E3]
Co-authorsBrett Nixon
2006Baker MA, Curry BJ, Aitken RJ, 'Inactivation of C-ABL Via PKA During Capacitation of Mouse Spermatozoa', Book of Abstracts, Lorne, Victoria, Australia (2006) [E3]
Co-authorsBen Curry, Mark Baker
2006Baker MA, Reeves GM, Aitken RJ, 'New approaches towards the proteomic analysis of the human spermatozoon', Book of Abstracts, Chicago, Illinois (2006) [E3]
Co-authorsMark Baker
2006Nixon B, Walsh AK, Bielanowicz AJ, Aitken RJ, 'The role of molecular chaperones in sperm-oocyte interaction', Book of Abstracts, Chicago, Illinois (2006) [E3]
Co-authorsBrett Nixon
2006Holt JE, Andrew J, Roman SD, Stanger SJ, Aitken RJ, Peter K, McLaughlin EA, 'CXCR4/SDF-1 interaction in the embryonic and neonatal mouse tests', Book of Abstracts, Chicago, Illinois (2006) [E3]
Co-authorsJanet Holt, Eileen Mclaughlin, Shaun Roman
2005Baker MA, Aitken RJ, 'Identification of PP60C-SRC as the enzyme responsible for tyrosine phosphorylation and consequent hyperactivation during mouse sperm capacitation', JOURNAL OF ANDROLOGY, Seattle, WA (2005)
Author URL
Co-authorsMark Baker
2005Baker MA, Aitken RJ, 'Identification of PP60C-SRC as the enzyme responsible for tyrosine phosphorylation and consequent hyperactivation during mouse sperm capacitation', JOURNAL OF ANDROLOGY, Seattle, WA (2005)
Author URL
Co-authorsMark Baker
2005Holt JE, Aitken RJ, Roman SD, McLaughlin E, 'Use of RNA interference for the functional analysis of genes involved in ovarian development', MECHANISMS OF DEVELOPMENT (2005) [E3]
Author URL
Co-authorsJanet Holt, Eileen Mclaughlin, Shaun Roman
2004Holt JE, Aitken RJ, Roman SD, McLaughlin EA, 'Expression of the Chemokine CXCL12 and its receptor CXCR4 in the activating Mammalian Ovarian follicle', Reproduction, Fertility and Development, Sydney (2004) [E3]
Co-authorsJanet Holt, Eileen Mclaughlin, Shaun Roman
2004Paul JW, McLaughlin EA, Aitken RJ, 'Oolemmal Proteomics: Identification of the Oocyte Cell Surface Protein Complexes Involved in Sperm-egg Interaction', Reproduction, Fertility and Development, Sydney (2004) [E3]
Co-authorsEileen Mclaughlin
2004Nixon B, Bielanowicz AJ, Asquith KL, Aitken RJ, 'The Molecular Basis of Epididymal Sperm Maturation', Reproduction, Fertility and Development, Sydney (2004) [E3]
Co-authorsBrett Nixon
2004Walsh AK, Asquith KL, Thomas CM, Mitchell LA, Nixon B, Aitken RJ, 'Identification of Potential Zona Pellucida-binding Sperm Proteins using Heat Shock Protein 60', Reproduction, Fertility and Development, Sydney (2004) [E3]
Co-authorsBrett Nixon
2004Baleato R, Aitken RJ, Roman SD, 'Interaction between bone morphogenetic protein 4 and retinoid signalling in mouse spermatogenesis', Reproduction, Fettility and Development, Darling Harbour, NSW, Australia (2004) [E3]
Co-authorsShaun Roman
2004Asquith KL, Nixon B, McLaughlin EA, Aitken RJ, 'Tyrosine phosphorylation of mouse sperm proteins in a prerequisite for Zona Pellucida binding: potential involvement of molecular chaperones', Biology of Reproduction 2004 Special Issue, Vancouver, Canada (2004) [E3]
Co-authorsEileen Mclaughlin, Brett Nixon
2003Asquith KL, Nixon B, Aitken RJ, 'Surface Localisation of Chaperone Proteins in Spermatozoa', 28th Annual Lorne Conference on Protein Structure & Function, Lorne, Victoria (2003) [E3]
Co-authorsBrett Nixon
2003Nixon B, Paul JW, Aitken RJ, 'Wheat germ agglutinin induced tyrosine phosphorylation of human spermatozoa', 28th Annual Lorne Conference on Protein Structure & Function, Lorne, Victoria (2003) [E3]
Co-authorsBrett Nixon
2003Holt JE, Aitken RJ, Roman SD, McLaughlin EA, 'Gene expression in the activating mammalian ovarian follicle', ComBio Combined Conference Abstracts, Melbourne (2003) [E3]
Co-authorsEileen Mclaughlin, Janet Holt, Shaun Roman
2003Baker MA, Hetherington L, Ecroyd HW, Roman SD, Aitken RJ, 'Analysis of the mechanism by which calcium negatively regulates the tyrosine phosphorylation cascade associated with sperm capacitation', ComBio Combined Conference Abstracts, Melbourne (2003) [E3]
CitationsScopus - 63Web of Science - 56
Co-authorsShaun Roman, Mark Baker
2003Baleato R, Aitken RJ, Roman SD, 'Regulation of gene expression in mouse germ cells by retinoids', ComBio Combined Conference Abstracts, Melbourne (2003) [E3]
Co-authorsShaun Roman
2003Blackmore DG, McLaughlin EA, Aitken RJ, 'Lectin expression patterns of feline and canine oogenesis', ComBio Combined Conference Abstracts, Melbourne (2003) [E3]
Co-authorsEileen Mclaughlin
2003Roman SD, Baleato R, Aitken RJ, 'Retinoid responsiveness of the murine spermatogonial cell line GC-1', Functional Genomics of Male Reproductions, Phoenix, Arizona (2003) [E3]
Co-authorsShaun Roman
2003Nixon B, Attwell-Heap AG, Paul JW, Aitken RJ, 'Wheat Germ Agglutinin Induced Tyrosine Phosphorylation of Human Spermatozoa', Reproduction, Fertility and Development, Melbourne (2003) [E3]
Co-authorsBrett Nixon
2003Asquith KL, McLaughlin EA, Nixon B, Aitken RJ, 'Localisation of Tyrosine Phosphorylated Proteins on Mouse Spermatozoa during Zona Pellucida Interaction and Characterisation of Sperm Surface Phosphoproteins', Society for Reproductive Biology Proceedings of the Thirty-fourth Annual Conference, Melbourne (2003) [E3]
Co-authorsEileen Mclaughlin, Brett Nixon
2003Aitken RJ, Baker MW, Krutskikh A, 'Oxidative Stress and Redox Regulation in the Epididymis', The Third International Conference on the Epididymis, Charlottesville, Virginia (2003) [E1]
2003Wade MA, Roman SD, Jones RC, Aitken RJ, 'Gene Expression of Adenylyl Cyclase in Rat Testis', The Third International Conference on the Epididymis, Charlottesville, Virginia (2003) [E3]
Co-authorsShaun Roman
2003Ecroyd HW, Jones RC, Aitken RJ, 'Tyrosine Phosphorylation in Murine Spermatozoa: Effect of Epididymal Maturation', The Third International Conference on the Epididymis, Charlottesville, Virginia (2003) [E3]
2003Jones RC, Knee RA, Ecroyd HW, Hansbro NG, Clulow J, Aitken RJ, Beagley KW, 'Delivery of Antibodies for Male Immunocontraception', The Third International Conference on the Epididymis, Charlottesville, Virginia (2003) [E3]
Co-authorsJohn Clulow, Nicole Hansbro
2002Asquith KL, Ecroyd HW, Aitken RJ, 'Tyrosine phosphorylation and epididymal maturation in murine spermatozoa', Proceedings of the Thirty-third Annual Conference of the Society for Reproductive Biology, Adelaide, SA (2002) [E3]
2002Sawyer DE, Aitken RJ, 'Iron is highly genotoxic toward human spermatozoa', Proceedings of the Thirty-third Annual Conference of the society for Reproductive Biology, Adelaide, SA (2002) [E3]
2002Baker MA, Krutskikh A, Aitken RJ, 'Redox regulation of sperm function', Proceedings of the Thirty-third annual Conference of the Society for Reproductive Biology, Adelaide, SA (2002) [E3]
Co-authorsMark Baker
2002Wade MA, Roman SD, Jones RC, Aitken RJ, 'Gene expression of adenylyl cyclase in rat testis and caudal epididymal sperm', Reproduction, Fertility and Development, Adelaide, SA (2002) [E3]
Co-authorsShaun Roman
2002Bennetts LE, Sawyer DE, Aitken RJ, 'Investigation of the effect of oestrogenic agents on DNA damage in the male germ line', Proceedings of the Australian Health and Medical Research Congress 2002, Melbourne, Vic (2002) [E3]
2002Aitken RJ, Baker MA, Krutskikh A, 'Oxidative stress and redox regulation in the epididymis', Epididymis III. Third International Conference on the Epididymis., Charlottesville, Virginia, USA (2002) [E3]
Co-authorsMark Baker
2002Baleato R, Aitken RJ, Roman SD, 'Retinoid Responsiveness of Adult Murine Germ Cells', Proceedings of the Australian Society for Biochemistry and Molecular Biology, Sydney, NSW (2002) [E3]
Co-authorsShaun Roman
2002Sutton KA, Wallace C, Aitken RJ, Roman SD, 'Identifying markers of the mammalian male germ line using subtractive hybridisation', Proceedings of the Australian Society for Biochemistry and Molecular Biology, Sydney, NSW (2002) [E3]
Co-authorsShaun Roman
2002Asquith KL, Ecroyd HW, Aitken RJ, 'Tyrosine phosphorylatoin and epididymal maturation in murine spermatozoa', Proceedings of the Australian Society for Biochemistry and Molecular Biology, Sydney, NSW (2002) [E3]
2002Curry BJ, Su Hua S, Law E, Aitken RJ, 'Spermatozoa cell signalling: characterization and significance of a novel GTPase activating protein (GAP) identified in mammalian spermatozoa', Proceedings of the Australian Society for Biochemistry and Molecular Biology, Sydney, NSW (2002) [E3]
Co-authorsBen Curry
2001Sawyer DE, Aitken RJ, 'Environmental pollution: Effects on male fertility and germline mutagenesis', Environmental Geotechnics, Newcastle, NSW (2001) [E1]
1998Aitken RJ, Irvine DS, 'Reliability of methods for assessing the fertilizing capacity of human spermatozoa', MODERN ART IN THE 2000S, GENK, BELGIUM (1998)
Author URL
CitationsWeb of Science - 1
1997Aitken RJ, 'Immunological contraception', CURRENT ADVANCES IN ANDROLOGY, SALZBURG, AUSTRIA (1997)
Author URL
1996Paterson M, Wilson MR, vanDuin M, Aitken RJ, 'Evaluation of zona pellucida antigens as potential candidates for immunocontraception', JOURNAL OF REPRODUCTION AND FERTILITY, NEW DELHI, INDIA (1996)
Author URL
1995Aitken RJ, 'Free radicals, lipid peroxidation and sperm function', REPRODUCTION FERTILITY AND DEVELOPMENT, CAIRNS, AUSTRALIA (1995)
DOI10.1071/RD9950659Author URL
CitationsScopus - 306Web of Science - 274
1995Mortimer D, Aitken RJ, Mortimer ST, Pacey AA, 'Workshop report: Clinical CASA - The quest for consensus', REPRODUCTION FERTILITY AND DEVELOPMENT, CAIRNS, AUSTRALIA (1995)
DOI10.1071/RD9950951Author URL
CitationsWeb of Science - 44
1995Aitken RJ, 'Oxygen radicals, IVF and male infertility', ADVANCES IN HUMAN REPRODUCTION, BALI, INDONESIA (1995)
Author URL
1995Aitken RJ, 'Sperm preparation in male factor infertility', ADVANCES IN HUMAN REPRODUCTION, BALI, INDONESIA (1995)
Author URL
1994AITKEN RJ, IRVINE DS, 'SPERM MOVEMENT ANALYSIS', MALE FACTOR IN HUMAN INFERTILITY, AMER HOSP PARIS, PARIS, FRANCE (1994)
Author URL
CitationsWeb of Science - 1
1993Aitken RJ, 'Cell biology of the oocyte', Gonadal Development and Function, Rome (1993)
1993Aitken RJ, 'Molecular basis of sperm-egg interaction', Gonadal Development and Function, Rome (1993)
1991AITKEN RJ, 'EVALUATION OF THE 50 HZ PAL VERSION OF THE HAMILTON THORN MOTILITY ANALYZER', COMPARATIVE SPERMATOLOGY 20 YEARS AFTER, SIENA, ITALY (1991)
Author URL
1991AITKEN RJ, 'REACTIVE OXYGEN SPECIES AND HUMAN SPERM FUNCTION', COMPARATIVE SPERMATOLOGY 20 YEARS AFTER, SIENA, ITALY (1991)
Author URL
CitationsWeb of Science - 4
1990AITKEN RJ, PATERSON M, BRAUDE P, KOOTHAN PT, 'EVALUATION OF GLYCOSYLATED AND DEGLYCOSYLATED PORCINE ZONA ANTIGENS FOR CONTRACEPTIVE EFFICACY INVIVO AND INVITRO', GAMETE INTERACTION, SAN CARLOS BARILOCHE, ARGENTINA (1990)
Author URL
CitationsWeb of Science - 8
1990Aitken RJ, Irvine DS, 'Molecular mechanisms that control sperm function', Gamete Physiology, USA (1990)
1990Aitken RJ, 'Cell biology of the human spermatozoon', Patrick Steptoe Memorial Symposium, unknown (1990)
1989Aitken RJ, 'Sperm-egg Interaction', Recent Advances in Andrology, Rome (1989)
1987Aitken RJ, Irvine DS, Clarkson JS, Richardson DW, 'Defective sperm function in human infertility', Annals of the New York Academy of Sciences, unknown (1987)
1986Aitken RJ, 'Immunological approaches to contraception', Advances in Fertility Regulation in the Male, unknown (1986)
1986Aitken RJ, 'Analysis of human sperm function', Advances in Fertility Regulation in the male, unknown (1986)
1986Aitken RJ, Lincoln DW, 'Human embryo research, the case for contraception', Human Embryo Research, Yes or No, unknown (1986)
1985Aitken RJ, Best FSM, Richardson DW, 'In vitro assessment of human sperm function', WHO/ICMR, unknown (1985)
1984Aitken RJ, Farzad Z, Hulme MJ, Richardson DW, 'The immunological disruption of fertilization', Proceedings of the 7th International Congress of Endocrinology, unknown (1984)
1984Kelly RW, Aitken RJ, Crosby J, 'Seminal prostaglandins and sperm function', Proceedings of the 7th International Congress of Endocrinology, unknown (1984)
1982Aitken RJ, 'The role of anti-zona and anti-sperm antibodies in the development of fertility regulating vaccines', British Journal of Clinical Practice. Supplement, unknown (1982)
1980Aitken RJ, 'Blastocyst proteins', Proceedings of the VI International Congress of Endocrinology, unknown (1980)
1979Aitken RJ, 'The hormonal control of implantation', Maternal Recognition Pregnancy, unknown (1979)
1977Aitken RJ, 'Mechanisms involved in implantation of the blastocyst', Fertility and Infertility, Leyden, The Netherlands (1977)
Show 126 more conferences

Patent (2 outputs)

YearCitationAltmetricsLink
2005Aitken RJ, Ainsworth CJ, Sperm cell separation by electrophoresis (2005) [I2]
2004Aitken RJ, Method for reducing the reproductive potential of a female animal (2004) [I3]
Edit

Grants and Funding

Summary

Number of grants134
Total funding$43,706,943

Click on a grant title below to expand the full details for that specific grant.


20155 grants / $1,231,334

Is placental aging the key to understanding, predicting and preventing stillbirth?$458,957

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Roger Smith, Laureate Professor John Aitken, Professor Jonathan Morris
SchemeProject Grant
RoleInvestigator
Funding Start2015
Funding Finish2015
GNoG1400191
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Use of quinone adducted peptides in the regulation of fertility$403,300

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken, Associate Professor Brett Nixon
SchemeDiscovery Projects
RoleLead
Funding Start2015
Funding Finish2015
GNoG1400318
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Izumo1 and its role in male infertility and male contraception$307,077

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Mark Baker, Laureate Professor John Aitken, Dr Christopher Gordon
SchemeProject Grant
RoleInvestigator
Funding Start2015
Funding Finish2015
GNoG1400190
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Research Connections Project$60,000

Funding body: Department of Industry

Funding bodyDepartment of Industry
Project TeamLaureate Professor John Aitken, Doctor Zamira Gibb
SchemeEntrepreneurs’ Infrastructure Programme
RoleLead
Funding Start2015
Funding Finish2015
GNoG1500086
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

2014 Vice Chancellors Award for Supervision Excellence - Faculty of Science and IT$2,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor John Aitken
SchemeAward for Supervision Excellence
RoleLead
Funding Start2015
Funding Finish2015
GNoG1401479
Type Of FundingInternal
CategoryINTE
UONY

20147 grants / $1,218,828

Dual purpose contraception $658,952

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor John Aitken, Professor Adam McCluskey, Professor Kenneth Beagley
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1300304
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Quinone-­-adducted FSH peptides as mediators of germ cell depletion: proof of concept study in mice$516,376

Funding body: Found Animals Foundation Inc

Funding bodyFound Animals Foundation Inc
Project TeamLaureate Professor John Aitken
SchemeMichelson Grants in Reproductive Biology
RoleLead
Funding Start2014
Funding Finish2014
GNoG1300906
Type Of FundingInternational - Competitive
Category3IFA
UONY

Oxidative stress in the male germ line; origins and management strategies $10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor John Aitken
SchemeNear Miss Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1301394
Type Of FundingInternal
CategoryINTE
UONY

Development of contraception on demand $10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Brett Nixon, Laureate Professor John Aitken
SchemeNear Miss Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301399
Type Of FundingInternal
CategoryINTE
UONY

Is placental aging the key to understanding, predicting and preventing stillbirth?$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Roger Smith, Laureate Professor John Aitken
SchemeNear Miss Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301406
Type Of FundingInternal
CategoryINTE
UONY

Stallion Research Program$10,000

Funding body: Scone Race Club

Funding bodyScone Race Club
Project TeamLaureate Professor John Aitken, Doctor Zamira Gibb
SchemeDonation
RoleLead
Funding Start2014
Funding Finish2014
GNoG1400536
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Faculty Visiting Fellowship 2014$3,500

Funding body: University of Newcastle - Faculty of Science & IT

Funding bodyUniversity of Newcastle - Faculty of Science & IT
Project TeamLaureate Professor John Aitken
SchemeVisiting Fellowship
RoleLead
Funding Start2014
Funding Finish2014
GNoG1401046
Type Of FundingInternal
CategoryINTE
UONY

20138 grants / $2,114,717

HMRI MRSP Infrastructure (12-16) – PRRP (Pregnancy & Reproduction Research Program)$851,574

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Roger Smith, Laureate Professor John Aitken
SchemeNSW MRSP Infrastructure Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1300914
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Triple Quadrupole Mass Spectrometer with nano-infusion for targeted protein quantification$300,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Mark Baker, Laureate Professor John Aitken, Conjoint Professor Bogdan Dlugogorski, Professor Hubert Hondermarck
SchemeEquipment Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1200137
Type Of FundingInternal
CategoryINTE
UONY

Modulation of telomere length and subtelomeric DNA methylation in response to oxidative stress in the male germ line; implications for tumorigenesis in the offspring$299,961

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor John Aitken
SchemeProject Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1200245
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Novel function of heat shock protein 2A in the regulation of human sperm-egg interactions$292,182

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Brett Nixon, Laureate Professor John Aitken, Professor Eileen McLaughlin
SchemeProject Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1200193
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Advanced Stopped Flow - Electron Paramagnetic Resonance Apparatus for Measurement of Short-Lived Free Radicals in Engineering, Science and Medicine$180,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamConjoint Professor Bogdan Dlugogorski, Professor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Scott Donne
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1200569
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Advanced Stopped Flow - Electron Paramagnetic Resonance Apparatus for Measurement of Short-Lived Free Radicals in Engineering, Science and Medicine$175,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Bogdan Dlugogorski, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Scott Donne, Professor Adam McCluskey
SchemeEquipment Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1200186
Type Of FundingInternal
CategoryINTE
UONY

NucleoCounter SP100$14,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor John Aitken, Associate Professor Brett Nixon, Doctor Shaun Roman, Doctor Mark Baker, Doctor Geoffry De Iuliis, Doctor Lisa Mitchell, Doctor Matthew Jobling, Doctor Zamira Gibb, Mr Nenad Naumovski
SchemeEquipment Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1201175
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

2012 EIA Impact Trial Travel Grant$2,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor John Aitken
SchemeTravel Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300369
Type Of FundingInternal
CategoryINTE
UONY

20126 grants / $1,257,061

Enhancing the efficiency of equine reproduction: relevant to the Thoroughbred and Standardbred breeding industries. $420,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken, Doctor Zamira Gibb
SchemeLinkage Projects
RoleLead
Funding Start2012
Funding Finish2012
GNoG1100533
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Pregnancy and Reproduction MRSP 2011-12 $369,134

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Roger Smith, Laureate Professor John Aitken, Conjoint Professor Keith Jones
SchemeNSW MRSP Infrastructure Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1101192
Type Of FundingOther Public Sector - State
Category2OPS
UONY

BD FACSAria III Cell Sorter: 3 laser 10-colour Flow Cytometer$180,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson, Laureate Professor John Aitken, Professor Roger Smith, Professor Rodney Scott
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100746
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

BD FACSAria III Cell Sorter: 3 laser 10-colour Flow Cytometer$150,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor Paul Foster, Professor Trevor Day, Conjoint Professor Peter Gibson, Laureate Professor John Aitken, Professor Roger Smith, Professor Rodney Scott
SchemeEquipment Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1100744
Type Of FundingInternal
CategoryINTE
UONY

BD FACSAria III Cell Sorter: 3 laser 10-colour Flow Cytometer$122,927

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamLaureate Professor Paul Foster, Conjoint Professor Peter Gibson, Laureate Professor John Aitken, Professor Roger Smith, Professor Rodney Scott
SchemeProject Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200668
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

BMG SPECTROstar Nano$15,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor John Aitken, Professor Eileen McLaughlin, Ms Belinda Nixon, Doctor Shaun Roman, Doctor Mark Baker, Doctor Geoffry De Iuliis, Doctor Lisa Mitchell, Doctor Matthew Jobling
SchemeEquipment Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1100971
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

201110 grants / $2,360,000

Chemical principles underpinning a spermostatic-microbiostatic agent capable of preventing pregnancy and the spread of sexually transmitted disease$735,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken, Doctor Mark Baker, Professor Kenneth Beagley, Professor Adam McCluskey
SchemeDiscovery Projects
RoleLead
Funding Start2011
Funding Finish2011
GNoG1000173
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Establishment of a comprehensive regional biophysical analysis facility $500,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Peter Lewis, Professor Nicholas Dixon, Professor Eileen McLaughlin, Professor Adam McCluskey, Associate Professor Aaron Oakley, Laureate Professor Paul Foster, Laureate Professor John Aitken, Associate Professor Jennifer Beck, Dr Michael Kelso, Professor Graham Nicholson, Associate Professor Elizabeth Harry, Professor Ian Charles, Associate Professor Steven Djordjevic
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1000630
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Impact of the male germ line on the mutational load carried by mammalian embryos$340,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken, Professor Bruce King
SchemeDiscovery Projects
RoleLead
Funding Start2011
Funding Finish2011
GNoG1000156
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

An Advanced Mass Spectrometer for Applications in Phospho-Proteomics, Glycomics and Top-Down Sequencing of Proteins$250,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamDoctor Mark Baker, Laureate Professor John Aitken, Professor Roger Smith, Conjoint Professor Keith Jones, Conjoint Professor Ray Rose, Professor Lois Salamonsen
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1000632
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Establishment of a comprehensive regional biophysical analysis facility $230,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Peter Lewis, Professor Nicholas Dixon, Professor Eileen McLaughlin, Professor Adam McCluskey, Associate Professor Aaron Oakley, Laureate Professor Paul Foster, Laureate Professor John Aitken, Associate Professor Jennifer Beck, Dr Michael Kelso, Professor Graham Nicholson, Associate Professor Elizabeth Harry, Professor Ian Charles, Associate Professor Steven Djordjevic
SchemeLinkage Infrastructure Equipment & Facilities (LIEF) Partner funding
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100484
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

3D Ion Trap Mass Spectrometer with ETD for Top Down Proteomics Applications$170,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Mark Baker, Laureate Professor John Aitken
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1000470
Type Of FundingInternal
CategoryINTE
UONY

Stallion Fertility Research Project$60,000

Funding body: NSW Trade & Investment

Funding bodyNSW Trade & Investment
Project TeamLaureate Professor John Aitken
SchemeTechVouchers Program
RoleLead
Funding Start2011
Funding Finish2011
GNoG1100764
Type Of FundingOther Public Sector - State
Category2OPS
UONY

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Phil Hansbro, Laureate Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100037
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Development of novel semen extenders to improve outcomes in equine assisted reproduction$15,000

Funding body: NSW Trade & Investment

Funding bodyNSW Trade & Investment
Project TeamLaureate Professor John Aitken
SchemeTechVouchers Program
RoleLead
Funding Start2011
Funding Finish2011
GNoG1100763
Type Of FundingOther Public Sector - State
Category2OPS
UONY

An Advanced Mass Spectrometer for Applications in Phospho-Proteomics, Glycomics and Top-Down Sequencing of Proteins$15,000

Funding body: Prince Henry's Institute of Medical Research

Funding bodyPrince Henry's Institute of Medical Research
Project TeamDoctor Mark Baker, Laureate Professor John Aitken, Professor Roger Smith, Conjoint Professor Keith Jones, Conjoint Professor Ray Rose, Professor Lois Salamonsen
SchemeLinkage Infrastructure Equipment & Facilities (LIEF) Partner funding
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100844
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

201011 grants / $3,698,835

Development of a humane non-surgical sterilization method for domestic animals$1,006,825

Funding body: Found Animals Foundation Inc

Funding bodyFound Animals Foundation Inc
Project TeamLaureate Professor John Aitken, Professor Eileen McLaughlin, Professor Adam McCluskey
SchemeMichelson Grants in Reproductive Biology
RoleLead
Funding Start2010
Funding Finish2010
GNoG0900113
Type Of FundingInternational - Competitive
Category3IFA
UONY

Sex Ratio and Sterility for Commercial animal production - round 5 Cluster$700,000

Funding body: CSIRO - Commonwealth Scientific and Industrial Research Organisation

Funding bodyCSIRO - Commonwealth Scientific and Industrial Research Organisation
Project TeamLaureate Professor John Aitken, Professor Eileen McLaughlin, Doctor Shaun Roman
SchemeNational Research Flagship Cluster
RoleLead
Funding Start2010
Funding Finish2010
GNoG1000045
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$500,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Phillip Robinson, Professor Eileen McLaughlin, Emeritus Professor Geoffrey Lawrance, Professor Marcel Maeder, Professor Hugh Dunstan, Doctor Shaun Roman, Professor Rob Atkin, Doctor Clovia Holdsworth, Doctor Mark Baker, Doctor Nikki Verrills, Professor Gottfried Otting, Associate Professor Brett Nixon, Doctor Xiaojing Zhou, Ms Megan Chircop, Doctor Warwick Belcher
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG0190402
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

HMRI MRSP Infrastructure Grant (10-11) - PREGNANCY & REPRODUCTION$362,277

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Roger Smith, Laureate Professor John Aitken, Conjoint Professor Keith Jones
SchemeNSW MRSP Infrastructure Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1100474
Type Of FundingOther Public Sector - State
Category2OPS
UONY

An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$280,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Phillip Robinson, Professor Eileen McLaughlin, Emeritus Professor Geoffrey Lawrance, Professor Marcel Maeder, Professor Hugh Dunstan, Doctor Shaun Roman, Professor Rob Atkin, Doctor Clovia Holdsworth, Doctor Mark Baker, Doctor Nikki Verrills, Professor Gottfried Otting, Associate Professor Brett Nixon, Doctor Xiaojing Zhou, Ms Megan Chircop, Doctor Warwick Belcher
SchemeEquipment Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1000873
Type Of FundingInternal
CategoryINTE
UONY

Feasibility of Humane Camel Management$130,000

Funding body: CRC for Invasive Animals

Funding bodyCRC for Invasive Animals
Project TeamLaureate Professor John Aitken, Professor Eileen McLaughlin
SchemeResearch Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG1100665
Type Of FundingCRC - Cooperative Research Centre
Category4CRC
UONY

A novel method for controlling fertility and STD$109,733

Funding body: Bill and Melinda Gates Foundation

Funding bodyBill and Melinda Gates Foundation
Project TeamLaureate Professor John Aitken
SchemeGrand Challenges Explorations
RoleLead
Funding Start2010
Funding Finish2010
GNoG0900114
Type Of FundingInternational - Competitive
Category3IFA
UONY

Waters, Ultra high performance liquid chromatography system (nano-Aquity) $30,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Mark Baker, Laureate Professor John Aitken, Professor Adam McCluskey, Associate Professor Brett Nixon, Emeritus Professor John Rostas, Professor Eileen McLaughlin
SchemeEquipment Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1000051
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Development of instrumentation for the Assisted Conception Industry NUSEP$15,000

Funding body: NSW Trade & Investment

Funding bodyNSW Trade & Investment
Project TeamLaureate Professor John Aitken
SchemeTechVouchers Program
RoleLead
Funding Start2010
Funding Finish2010
GNoG1100765
Type Of FundingOther Public Sector - State
Category2OPS
UONY

20096 grants / $1,289,885

HMRI MRSP Infrastructure Grant (09-10) Pregnancy and Reproduction$296,789

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Roger Smith, Laureate Professor John Aitken, Conjoint Professor Keith Jones
SchemeNSW MRSP Infrastructure Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG1000642
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Confocal Laser Scanning Microscopy for Live Cell Imaging$275,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamConjoint Professor Keith Jones, Professor Eileen McLaughlin, Laureate Professor John Aitken, Conjoint Professor Ray Rose, Emeritus Professor John Patrick, Conjoint Professor Christina Offler, Associate Professor David McCurdy, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Professor Dirk Van Helden, Doctor Nikki Verrills, Associate Professor Brett Nixon, Doctor Shaun Roman, Associate Professor Yong-Ling Ruan, Doctor Rick Thorne, Professor Mike Calford
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189038
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Assessing the significance of the sperm thioredoxins as contraceptive targets for the male$148,096

Funding body: Contraceptive Research and Development Program

Funding bodyContraceptive Research and Development Program
Project TeamLaureate Professor John Aitken, Doctor Mark Baker
SchemeDevelopment of New or Improved Contraceptive Products
RoleLead
Funding Start2009
Funding Finish2009
GNoG0189339
Type Of FundingInternational - Non Competitive
Category3IFB
UONY

LAS-4000 Chemiluminescence imaging system$25,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Eileen McLaughlin, Laureate Professor John Aitken, Professor Peter Lewis, Associate Professor Brett Nixon, Doctor Shaun Roman
SchemeEquipment Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189852
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

200819 grants / $11,289,639

Centre for Biotechnology and Development$6,420,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken, Dr Gary Hime, Professor M Holland, Professor D Jans, Professor P Koopman, Dr Kate Loveland, Professor Eileen McLaughlin, Dr M O'Bryan, Doctor Shaun Roman, Assoc. Prof A Sinclair
SchemeARC Centres of Excellence
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188624
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Basic and clinical studies of fertility and infertility$1,950,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor John Aitken
SchemeProgram Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0187570
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

ARC CoE - CBD sub account - Proteomics Group$480,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken
SchemeARC Centres of Excellence
RoleLead
Funding Start2008
Funding Finish2008
GNoGS090010
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Centre for Biotechnology and Development$297,273

Funding body: NSW Department of State and Regional Development

Funding bodyNSW Department of State and Regional Development
Project TeamLaureate Professor John Aitken, Dr Gary Hime, Professor M Holland, Professor D Jans, Professor P Koopman, Dr Kate Loveland, Professor Eileen McLaughlin, Dr M O'Bryan, Doctor Shaun Roman, Assoc. Prof A Sinclair
SchemeCentres of Excellence (Partner)
RoleLead
Funding Start2008
Funding Finish2008
GNoG0189183
Type Of FundingOther Public Sector - State
Category2OPS
UONY

ARC CoE - CBD sub account - DNA Damage Group$270,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken
SchemeARC Centres of Excellence
RoleLead
Funding Start2008
Funding Finish2008
GNoGS090002
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

ARC CoE - CBD sub account - Discretionary fund$225,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken
SchemeARC Centres of Excellence
RoleLead
Funding Start2008
Funding Finish2008
GNoGS090013
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

ARC CoE - CBD sub account - Travel$222,546

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken
SchemeARC Centres of Excellence
RoleLead
Funding Start2008
Funding Finish2008
GNoGS090015
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

ARC CoE - CBD sub account - Stem Cell Culture Group$210,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken
SchemeARC Centres of Excellence
RoleLead
Funding Start2008
Funding Finish2008
GNoGS090011
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

ARC CoE - CBD sub account - Transfection Technologies$210,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken
SchemeARC Centres of Excellence
RoleLead
Funding Start2008
Funding Finish2008
GNoGS090012
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

ARC CoE - CBD sub account - Sperm Biology$210,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken
SchemeARC Centres of Excellence
RoleLead
Funding Start2008
Funding Finish2008
GNoGS090017
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

ARC CoE - CBD sub account - Equipment$180,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken
SchemeARC Centres of Excellence
RoleLead
Funding Start2008
Funding Finish2008
GNoGS090016
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

CBD Sub account - Flagships$164,431

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken
SchemeARC Centres of Excellence
RoleLead
Funding Start2008
Funding Finish2008
GNoGS100007
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Feasibility of camel fertility control$130,000

Funding body: CRC for Invasive Animals

Funding bodyCRC for Invasive Animals
Project TeamLaureate Professor John Aitken
SchemeResearch Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0189150
Type Of FundingCRC - Cooperative Research Centre
Category4CRC
UONY

CBD Sub account - Publications & Patents 03-07$120,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken
SchemeARC Centres of Excellence
RoleLead
Funding Start2008
Funding Finish2008
GNoGS100005
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

CBD Sub account - Researcher Networking$102,320

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken
SchemeARC Centres of Excellence
RoleLead
Funding Start2008
Funding Finish2008
GNoGS100006
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

CBD Sub account - SPIF1 (Aitken, Roman & O'Bryan)$45,569

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken
SchemeARC Centres of Excellence
RoleLead
Funding Start2008
Funding Finish2008
GNoGS100008
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

ARC CoE - CBD sub account - Admin$30,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken
SchemeARC Centres of Excellence
RoleLead
Funding Start2008
Funding Finish2008
GNoGS090014
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

CBD Sub account - Medicinal Chemistry$20,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken
SchemeARC Centres of Excellence
RoleLead
Funding Start2008
Funding Finish2008
GNoGS100004
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

5th European Congress of ANdrology, Jolly Hotel Vittoria Veneto (Corso Italia, 1), 26/11/2008 - 28/11/2008$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor John Aitken
SchemeTravel Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0189331
Type Of FundingInternal
CategoryINTE
UONY

20078 grants / $1,651,113

HMRI - Pregnancy and Reproductive Research program$762,155

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Roger Smith, Laureate Professor John Aitken
SchemeNSW MRSP Infrastructure Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187760
Type Of FundingOther Public Sector - State
Category2OPS
UONY

FACSAria - Fluorescence activated cell sorter$300,000

Funding body: Cancer Institute NSW

Funding bodyCancer Institute NSW
Project TeamDoctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
SchemeResearch Infrastructure Grants
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187666
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

AMPPAII Proposal for completion of the Sptrx KO mice study$198,741

Funding body: Schering AG

Funding bodySchering AG
Project TeamLaureate Professor John Aitken, Doctor Mark Baker
SchemeResearch Networks
RoleLead
Funding Start2007
Funding Finish2007
GNoG0188468
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Biotechnology applications in the veterinary pharmacuetical industry: Pharmacological manipulation of ovarian function in domestic animals$134,998

Funding body: Pestat Pty Ltd

Funding bodyPestat Pty Ltd
Project TeamProfessor Eileen McLaughlin, Laureate Professor John Aitken
SchemeLinkage Projects Partner funding
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188204
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Centre for Biotechnology and Development.$96,220

Funding body: NSW Department of State and Regional Development

Funding bodyNSW Department of State and Regional Development
Project TeamLaureate Professor John Aitken, Dr Kate Loveland, Professor P Koopman, Assoc. Prof A Sinclair, Professor D De Krester, Dr M O'Bryan, Dr Gary Hime, Professor D Jans, Doctor Shaun Roman, Professor Eileen McLaughlin, Professor C Goodnow, Professor M Holland
SchemeCentres of Excellence (Partner)
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187937
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Equipment Grant - Centrifuge$68,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Roger Smith, Laureate Professor John Aitken
SchemeNSW Dept Health - Infrastructure Funding
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188006
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

HMRI Contribution toward FACSAria - Fluorescence activated cell sorter$52,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Nikki Verrills, Emeritus Professor Leonie Ashman, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alistair Sim, Doctor Rick Thorne, Doctor Jennette Sakoff
SchemeEquipment Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188207
Type Of FundingOther Public Sector - State
Category2OPS
UONY

(28) PRC - Priority Research Centre for Reproductive Science$38,999

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Roger Smith, Laureate Professor John Aitken
SchemePublication Performance Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187970
Type Of FundingInternal
CategoryINTE
UONY

20065 grants / $1,840,163

Australian Network II$1,036,108

Funding body: Schering AG

Funding bodySchering AG
Project TeamLaureate Professor John Aitken
SchemeResearch Networks
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186922
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

PRC - Priority Research Centre for Reproductive Science$544,282

Funding body: University of Newcastle

Molecular basis of defective sperm function$232,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor John Aitken, Professor Gordon Baker
SchemeProject Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0185144
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Environmental impacts on female fertility and the menopause$17,273

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Eileen McLaughlin, Laureate Professor John Aitken, Doctor Shaun Roman
SchemeResearch Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186620
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Sperm Biology$10,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamLaureate Professor John Aitken
SchemeSparke Helmore/NBN Television Corporate Triathlon Award for Research Excellence
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186160
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20057 grants / $703,455

Ovarian proteomics. Strategies for identification of targets for contraception in the ovary.$262,255

Funding body: Schering AG

Funding bodySchering AG
Project TeamLaureate Professor John Aitken
SchemeResearch Networks
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185645
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

2005 RIBG allocation$81,200

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor John Aitken
SchemeResearch Infrastructure Block Grant (RIBG)
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185836
Type Of FundingInternal
CategoryINTE
UONY

2005 RIBG allocation$65,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor John Aitken
SchemeResearch Infrastructure Block Grant (RIBG)
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185843
Type Of FundingInternal
CategoryINTE
UONY

Two dimensional Liquid chromatography Ion Trap Mass Spectrometer (with software)$63,811

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor John Aitken
SchemeEquipment Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185468
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Gene profiling of the detoxifying enzymes in the male germ line$15,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Shaun Roman, Laureate Professor John Aitken
SchemeProject Grant
RoleInvestigator
Funding Start2005
Funding Finish2005
GNoG0184897
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

The initiation of fertilisation: Characterisation of the sperm receptor complex for the oocyte$9,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Brett Nixon, Laureate Professor John Aitken
SchemeProject Grant
RoleInvestigator
Funding Start2005
Funding Finish2005
GNoG0184742
Type Of FundingInternal
CategoryINTE
UONY

20049 grants / $1,283,059

Biotechnology applications in the veterinary pharmaceutical industry: Pharmacological manipulation of ovarian function in domestic animals$465,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Eileen McLaughlin, Laureate Professor John Aitken, Dr J O'Brien
SchemeLinkage Projects
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183627
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Biotechnology applications in the veterinary pharmacuetical industry: Pharmacological manipulation of ovarian function in domestic animals$298,368

Funding body: Jurox

Funding bodyJurox
Project TeamProfessor Eileen McLaughlin, Laureate Professor John Aitken, Dr J O'Brien
SchemeLinkage Projects Partner funding
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183816
Type Of FundingNot Known
CategoryUNKN
UONY

High-Speed Confocal Microscope Live Cell Recording System$274,692

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Dirk Van Helden, Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Alan Brichta, Associate Professor J Keast, Dr J Brock, Dr S Head
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183031
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Biacore3000-Expansion of Proteomics Facility$187,341

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Alistair Sim, Laureate Professor John Aitken, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Emeritus Professor Leonie Ashman, Professor Roger Smith, Professor Gordon Burns, Professor Adam McCluskey, Associate Professor Paul Tooney, Dr Fraser Ross, Conjoint Professor Ray Rose
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183030
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

High-speed Confocal Microscope Live Cell Recording System$30,000

Funding body: University of New South Wales

Funding bodyUniversity of New South Wales
Project TeamProfessor Dirk Van Helden, Associate Professor J Keast, Laureate Professor John Aitken, Dr J Brock, Professor Eileen McLaughlin, Dr S Head, Professor Alan Brichta
SchemeLinkage Infrastructure Equipment & Facilities (LIEF) Partner funding
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183841
Type Of FundingNot Known
CategoryUNKN
UONY

Development of an in vitro system for studying the maturation of mammalian spermatozoa$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Minjie Lin, Laureate Professor John Aitken
SchemeProject Grant
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183402
Type Of FundingInternal
CategoryINTE
UONY

In vivo regulation of spermatogonial gene expression by Vitamin A$8,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Shaun Roman, Laureate Professor John Aitken
SchemeProject Grant
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183416
Type Of FundingInternal
CategoryINTE
UONY

DS Gene (software) and appropriate licensing computer$5,710

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor John Aitken
SchemeEquipment Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0184280
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Visit of Dr Sheena Lewis, 2 August to 10 September 2004$3,948

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor John Aitken
SchemeVisitor Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0184092
Type Of FundingInternal
CategoryINTE
UONY

20037 grants / $10,348,203

Centre for Biotechnology and Development.$9,458,900

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken, Dr Kate Loveland, Professor P Koopman, Assoc. Prof A Sinclair, Professor D De Krester, Dr M O'Bryan, Dr Gary Hime, Professor D Jans, Doctor Shaun Roman, Professor Eileen McLaughlin, Professor C Goodnow, Professor M Holland
SchemeARC Centres of Excellence
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182214
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Calcium as a key regulator of epididymal sperm maturation.$500,637

Funding body: Ernst Schering Research Foundation

Funding bodyErnst Schering Research Foundation
Project TeamLaureate Professor John Aitken
SchemeResearch Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0183348
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Redox cycling of quinones by human spermatozoa: a potential strategy for the dual regulation of fertility and STDs$300,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor John Aitken, Conjoint Associate Professor Renate Griffith
SchemeProject Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0181750
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Eppendorf Transferman NK2 micromanipulators with FemtoJet and CellTram microinjectors$30,000

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamLaureate Professor John Aitken
SchemeMajor Equipment Award
RoleLead
Funding Start2003
Funding Finish2003
GNoG0183199
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

The origin and control of oxidative stress in the placenta$29,666

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor John Aitken, Professor Roger Smith, Doctor Shaun Roman
SchemeMulti-Year Project Grant Scholarship
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182393
Type Of FundingInternal
CategoryINTE
UONY

The role of cytokines in the activation of the ovarian follicle.$17,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Eileen McLaughlin, Laureate Professor John Aitken
SchemeResearch Grant
RoleInvestigator
Funding Start2003
Funding Finish2003
GNoG0182197
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Oolemmal Proteomics - identification of oocyte cell surface protein complexes involved in sperm-egg interaction$12,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Eileen McLaughlin, Laureate Professor John Aitken
SchemeProject Grant
RoleInvestigator
Funding Start2003
Funding Finish2003
GNoG0182320
Type Of FundingInternal
CategoryINTE
UONY

20027 grants / $1,028,435

The Molecular Analysis of Variation and Gene Function.$545,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Rodney Scott, Laureate Professor John Aitken
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2002
Funding Finish2002
GNoG0181518
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Electron Microscope/X-Ray Unit Equipment Upgrade$337,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamConjoint Professor Christina Offler, Professor Bill Collins, Professor Erich Kisi, Professor Alan Brichta, Laureate Professor John Aitken, Emeritus Professor John Patrick
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2002
Funding Finish2002
GNoG0181515
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Use of Gradipore technology to develop novel methods for the preparation and segregation of mammalian spermatozoa$79,535

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken, Dr D Rylatt
SchemeLinkage Projects
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181141
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Use of Gradipore technology to develop novel methods for the preparation and segregation of mammalian spermatozoa$49,500

Funding body: Gradipore Ltd.

Funding bodyGradipore Ltd.
Project TeamLaureate Professor John Aitken, Dr D Rylatt
SchemeLinkage Projects Partner funding
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181717
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Oxidative Stress in the placenta: analysis of the source of free radicals$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor John Aitken, Professor Roger Smith
SchemeProject Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181444
Type Of FundingInternal
CategoryINTE
UONY

Characterisation of a non-genomic progesterone receptor in round spermatids$5,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Shaun Roman, Laureate Professor John Aitken
SchemeProject Grant
RoleInvestigator
Funding Start2002
Funding Finish2002
GNoG0181445
Type Of FundingInternal
CategoryINTE
UONY

First Mediterranean Congree on Reproductive Medicine, Taormina, Italy 3 - 6 November 2002$2,400

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor John Aitken
SchemeTravel Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0182623
Type Of FundingInternal
CategoryINTE
UONY

20019 grants / $894,740

Targeting a novel tyrosine kinase signal transduction pathway in mammalian spermatozoa.$377,500

Funding body: Ernst Schering Research Foundation

Funding bodyErnst Schering Research Foundation
Project TeamLaureate Professor John Aitken
SchemeResearch Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0180544
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Development of pharmaceutical agents for non-surgical sterilization.$229,860

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken
SchemeStrategic Partnerships with Industry - Research & Training Scheme (SPIRT)
RoleLead
Funding Start2001
Funding Finish2001
GNoG0179624
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Molecular characterization of unique recognition sites on the surface of human spermatozoa.$210,380

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor John Aitken, Dr Keith Sutton, Dr K Eidne
SchemeProject Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0179652
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Fluoresence Activated Cell Sorter - FACSCalibur System from Beckton Dickenson$22,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor John Aitken
SchemeEquipment Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0181177
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Development of pharmaceutical agents for non-surgical sterilization.$15,000

Funding body: Jurox

Funding bodyJurox
Project TeamLaureate Professor John Aitken
SchemeSPIRT Partner funding
RoleLead
Funding Start2001
Funding Finish2001
GNoG0181495
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Development of an Animal Model of Testicular Oxidative Stress.$11,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDr Dennis Sawyer, Laureate Professor John Aitken
SchemeProject Grant
RoleInvestigator
Funding Start2001
Funding Finish2001
GNoG0180011
Type Of FundingInternal
CategoryINTE
UONY

Impact of RF-EME on DNA integrity in the male germ line.$11,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor John Aitken, Professor Bruce King, Dr Dennis Sawyer
SchemeProject Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0180118
Type Of FundingInternal
CategoryINTE
UONY

The Ultramark Microplate Reader - BioRad$10,878

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamLaureate Professor John Aitken
SchemeEquipment Grant
RoleLead
Funding Start2001
Funding Finish2001
GNoG0181251
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The Ultramark Microplate Reader - BioRad$7,122

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor John Aitken
SchemeUniversity/NHMRC Equipment Grant Funds
RoleLead
Funding Start2001
Funding Finish2001
GNoG0181252
Type Of FundingInternal
CategoryINTE
UONY

20006 grants / $657,609

Molecular basis for sperm-egg recognition in the human.$456,638

Funding body: Ernst Schering Research Foundation

Funding bodyErnst Schering Research Foundation
Project TeamLaureate Professor John Aitken
SchemeResearch Grant
RoleLead
Funding Start2000
Funding Finish2000
GNoG0179183
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Molecular regulation of sperm function: biochemical mechanisms for the activation of motility and initiation of capacitation$160,046

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken, Conjoint Associate Professor Russell Jones, Raymond Murdoch
SchemeLarge Grant
RoleLead
Funding Start2000
Funding Finish2000
GNoG0178527
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Purchase of a Flow Cytometer for the University of Newcastle Biomolecular Research Facility.$18,000

Funding body: Ramaciotti Foundations

Funding bodyRamaciotti Foundations
Project TeamConjoint Professor Kenneth Beagley, Laureate Professor John Aitken
SchemeResearch Grant
RoleInvestigator
Funding Start2000
Funding Finish2000
GNoG0179764
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

Molecular Basis For Sperm-Egg Recognition in Human.$12,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor John Aitken, Dr Keith Sutton
SchemeProject Grant
RoleLead
Funding Start2000
Funding Finish2000
GNoG0178899
Type Of FundingInternal
CategoryINTE
UONY

Molecular basis of spermatogenesis$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDr Keith Sutton, Laureate Professor John Aitken, Doctor Shaun Roman
SchemeProject Grant
RoleInvestigator
Funding Start2000
Funding Finish2000
GNoG0178860
Type Of FundingInternal
CategoryINTE
UONY

ComBio 2000/Society for Free Radical Research meeting on Oxidants, Antioxidants & Nutrition, New Zealand, 8-12 December 2000$925

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor John Aitken
SchemeTravel Grant
RoleLead
Funding Start2000
Funding Finish2000
GNoG0180547
Type Of FundingInternal
CategoryINTE
UONY

19994 grants / $839,867

Redox regulation of mammalian sperm function:a strategy for post-testicular male contraception.$323,405

Funding body: Ernst Schering Research Foundation

Funding bodyErnst Schering Research Foundation
Project TeamLaureate Professor John Aitken
SchemeResearch Grant
RoleLead
Funding Start1999
Funding Finish1999
GNoG0178994
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Redox regulation of sperm function: implications for infertility and mutagenesis on the male germ line$309,030

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken
SchemeLarge Grant
RoleLead
Funding Start1999
Funding Finish1999
GNoG0177755
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Confocal Laser Scanning Microscope Facility.$203,107

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamLaureate Professor John Aitken, Emeritus Professor John Patrick, Conjoint Professor Christina Offler, Associate Professor David McCurdy, Conjoint Professor Ray Rose, Doctor Tim Roberts, Conjoint Associate Professor Russell Jones, Doctor John Clulow, Emeritus Professor John Rostas, Professor Alistair Sim, Professor Gordon Burns, Conjoint Professor Loris Chahl, DR DAVID KAY
SchemeLarge Equipment Grant
RoleLead
Funding Start1999
Funding Finish1999
GNoG0177945
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Visitor Grant for Dr Csilla Gabriella Krausz.$4,325

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamLaureate Professor John Aitken
SchemeVisitor Grant
RoleLead
Funding Start1999
Funding Finish1999
GNoG0179008
Type Of FundingInternal
CategoryINTE
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Repair of DNA Damage in Spermatozoa by the Early Embryo
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2015miRNAs in Sperm Maturation
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2015Investigating New Contraceptives; Immunocontraception
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2014Radiofrequency Electromagnetic Radiation and the Male Reproduction
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2014The Effects of Iron Dysregulation on the Heart, Lungs and Reproductive System
Health, Faculty of Health and Medicine
Co-Supervisor
2014Identification of Novel Immunocontraceptive Targets for Fertility Control of Feral Horses
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2014An Investigation of Equine Oocyte Maturation to Improve IVF and Embryo Retention Rates
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2013Study Spermatogenesis in a Native Marine Invertebrate Galeolaria Caespitosa and Investigate it's Potential as a Biomarker for Marine Pollution
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2013Generation of Gene-Disrupted Mice to Further Elucidate Reproductive Mechanisms in the Male Germ Cell
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2013Phage Peptides Fertility Control
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2013Post-Meiotic Sperm DNA Damage and Consequences to Offspring
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2012The Function of Molecular Chaperones in The Regulation of Human Sperm-Egg Recognition
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2012The Role of Reactive Oxygen Species and Oxidative Stress in Post-Ovulatory Ageing and Apoptosis of the Mammalian Oocyte
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2015Functional Characterisation of Dynamin in Mouse Spermatozoa
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2014The Genesis and Consequences of DNA Damage in the Male Germ Line
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2013New Insights into the Molecular Basis of Human Sperm-Egg Interaction
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2012The Molecular Basis of Sperm - Oocyte Interactions
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2011Epigenetic Modification in Human Male Germ Line
Health, Faculty of Health and Medicine
Principal Supervisor
2010Significance of Mitochondrial Reactive Oxygen Species Production in Male Infertility
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2010Large-Scale Proteomic Screen and Signal Transduction Analysis Used to Study Embryonic Gonad and Germ Cell Development
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2009The Molecular Basis of Human Sperm-Zona Pellucida Interaction
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2009Functional Maturation of Mouse Epididymal Spermatozoa
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2008Oolemmal Proteomics: Identification of Oocyte Cell Surface Protein Complexes Involved in Murine Fertilisation
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2007Identification of NADPH Oxidase in Mouse Spermatozoa
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2007The Development of a Novel Electrophoretic System for the Isolation of Human Spermatozoa
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2007Mechanisms of Quinone Spermostatic Activity and Toxicity
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2007Dogs, Dwellings and Disease: A Study of Free - Roaming Dogs in a Remote Aboriginal Community
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2006Non-Surgical Sterilisation of Female Domesticated Animals
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2006Redox Activity and DNA Damage in the Male Germ Line
Biological Sciences, Faculty of Science and Information Technology
Sole Supervisor
2006Gene Expression During Development of the Mammalian Ovarian Primordial Follicle
Biological Sciences, Faculty of Science and Information Technology
Co-Supervisor
2005The Molecular Basis of Sperm-Oocyte Interaction in the Mouse
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2004A Novel GTPase Activating Protein, RhoGaps, in the Male Gamete
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2004Activation of motility in spermatozoa from the cauda epididymidis of the rat
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
2003The Regulation of Tyrosine Phosphorylation in Mouse Spermatozoa
Biological Sciences, Faculty of Science and Information Technology
Principal Supervisor
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Research Collaborations

The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.

CountryCount of Publications
Australia243
United Kingdom205
United States17
Netherlands14
Germany7
More...
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News

Health and Medical Sciences Academy

Academy honour for UON leaders

March 26, 2015

Two University of Newcastle (UON) research leaders are among the distinguished health and medical scientists elected this week as Fellows of the Australian Academy of Health and Medical Sciences (AAHMS).

Laureate Professor John Aitken

UON researcher awarded fellowship

December 1, 2014

Laureate Professor John Aitken was recently elected a Fellow of The Royal Society of New South Wales (FRSN).

Australian Research Council (ARC)

ARC Discovery Project funding success

November 19, 2014

Laureate Professor John Aitken and Associate Professor Brett Nixon have been awarded more than $403,000 in ARC Discovery Project funding commencing in 2015 for their research project Use of quinone adducted peptides in the regulation of fertility.

Sperm symposium

International Symposium on Spermatology

August 11, 2014

Scientists at the forefront of sperm cell biology and fertilisation research throughout the world have gathered in Newcastle for the 12th International Symposium on Spermatology.

Hand with fork digging into food

Chemicals in household items linked to cancer

February 21, 2013

The United Nations has released a list of about 800 chemicals, many used in household products, that could damage the human hormone system.

Laureate Professor John Aitken

Newcastle biologist named NSW Scientist of the Year

November 14, 2012

The University of Newcastle's Laureate Professor John Aitken has been named NSW Scientist of the Year at the 2012 NSW Science and Engineering awards in Sydney.

Laureate Professor John Aitken

Position

Pro Vice-Chancellor
PRC in Reproductive Science
Office of the PVC Health and Medicine
Faculty of Health and Medicine

Focus area

Biological Sciences

Contact Details

Emailjohn.aitken@newcastle.edu.au
Phone(02) 4985 4466
Fax(02) 4921 5669

Office

RoomBB2-06
BuildingBowman Building
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
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