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Associate Professor Michael Bowyer

Deputy Head of Faculty

School of Environmental and Life Sciences (Chemistry)

Career Summary

Biography

From 1995 until present MB has been the sole chemist forming part of a multi-disciplinary academic group (known as the Discipline of Applied Sciences) based at the Ourimbah campus of the University of Newcastle. The campus has research specialisations in Food Technology, Human Nutrition, Sport Sciences & Marine Science. Opportunities for MB to develop an independent research profile in his field of training (synthetic organic chemistry) have been limited, however, he has successfully collaborated with a number of research groups with in the University of Newcastle (please see"Research Interests" for details. This work has seen the successful completion of 5 research higher degree students (PhD) and numerous Honours students. MB is the author of some 30 publications across a range research areas in high impact peer reviewed journals. In addition to maintaining an active research profile, MB has assumed a significant administrative role in the School of Environmental & Life Sciences since becoming Head of Discipline of Applied Sciences in 2006. Duties include day to day management of budget and staffing issues within the Discipline and participation in numerous committees and working parties at University, Faculty and School level. MB has also represented the Faculty internationally in the negotiation of academic twinning agreements with overseas tertiary institutions.

Research Expertise

MB trained as a research chemist with expertise in organic synthesis. He has a particular interest in how interactions between organic molecules act as signalling agents in both natural and synthetic systems. MB has established successful collaborative research with Emeritus Professor Ron Wills (Food Science & Human Nutrition - Newcastle University) to develop new, environmentally friendly treatments for extending the postharvest life of fresh farm produce using nitric oxide (NO) gas to delay senescence without refrigeration. While the role of NO in mammalian physiology is relatively well understood, its action in plants remains largely undefined. MB has utilised his skills as an organic chemist to synthesise zwitterionic NO donor compounds capable of delivering a precise quantity of NO gas in a controlled manner. Solid phase NO delivery has enhanced the scope and flexibility of NO fumigation technology by eliminating the need for cumbersome and expensive infrastructure (e.g. cylinders and regulators). The research has to date yielded 4 refereed journal articles (3 published, 1 submitted) and competitive grant funding of $26.5K. Work in this field has recently been extended to investigate the potential use of NO donor technology to control settlement behaviour in marine organisms. MB has co-supervised two PhD students (1 completed) and 2 Honours student (1 completed) in this field. MB has been involved in molecular imprinting research with Associate Professor Adam McCluskey since 1999 and Dr Clovia Holdsworth since 2002. Initial research (99-01, $92000) supported by the Grape & Wine Research & Development Corporation (GWRDC) focused on the successful development of MIPs for the selective sensing of chloroarene contaminants in wine. These findings were reported in two peer-reviewed articles (Aust. J. Chem, 2004, 57, 759; Aust. J. Chem, 2006, 59, 129) and at domestic and international conferences including the World Congress on Synthetic Receptors (Lisbon, Portugal, October 13-15, 2003). MBs current research is supported by separate ARC Linkage Grants. Work conducted in conjunction with the Australian Federal Police ($190,000 & $51,000 industry component) seeks to develop novel MIP-based sensors for the selective identification of a number of illicit substances. Computational modelling protocols have been developed to improve MIP formulation and selectivity by pre-screening target molecules against a library of commercial functional monomers to identify and rank favourable interactions. These important outcomes were reported in 2005 (Aust. J. Chem, 2005, 58, 315). Attention is currently focused on the preparation of MIP-based films for incorporation into a portable FTIR spectrophotometers to enable the assessment of crime scenes to be undertaken in-field in real time. Work with the Bureau of Sugar Research Stations ($171,336 & $45,000 industry component) aims to develop transitional metal-mediated MIPs capable of sequestering amino acids contaminants associated with the non-enzymatic browning of processed sugar. MIPs targeting high value, biologically active flavonoids are also being investigated to improve the competitiveness of the Australian sugar industry. MB has co-supervised five PhD students and 4 Honours students in the field of MIP research.

Teaching Expertise
As a foundation academic in the School of Applied Sciences, MB has been solely responsible for development, delivery assessment and administration of all chemistry courses taught at the University of Newcastles Ourimbah Campus. In a decade of service, MB has overseen an expansion in First Year Chemistry from an initial student intake of 7 students (1995) to enrolment numbers exceeding 140 students in 2007. MB currently undertakes all lecturing and tutoring teaching for the two 1000 level chemistry courses (CHEM1110 & CHEM1120) offered at Ourimbah. The courses are designed to provide an introduction to general & bioorganic chemistry for Life Science undergraduates. The face to face commitment is approximately 150 hours p.a. MB has also made teaching contributions to 2000 & 3000 level courses in the fields of environmental (CHEM2260, CHEM3260) and organic chemistry (CHEM2330, 33330) at the Ourimbah and Callaghan campuses of the University of Newcastle. Specialist 4000 level courses covering selected areas of heterocyclic synthesis have also been prepared. and delivered as part of the Discipline of Chemistrys Honours program at Callaghan. MB has fully embraced the use of modern teaching methods to delivery quality outcomes for students. Approaches utilised include: " Provision of comprehensive guidelines of all course content to ensure that students have a full understanding of the expected course outcomes and how those outcomes will be achieved. " Use of Blackboard as the main tool for the provision of course information to students. " Extensive use multimedia-based teaching methods to explain and enhance teaching in lectures and laboratories.

Administrative Expertise
MB has fulfilled a variety of administrative roles within the School of Environmental and Life Sciences of the University of Newcastle. Activities undertaken include: School Administration School of Applied Science (SAS) Timetable Coordinator (1995-1999): Responsibility for scheduling of UG courses (~50) taught by the SAS. Responsibilities included liasing with Callaghan-based staff to ensure timetable compatibility between campuses to allow for inter-campus teaching, and participation in workshops with other stakeholders at the Ourimbah campus to prioritise room allocations for classes. Honours Coordinator (SAS) (2001-2006): Responsibilities included vetting and approval of new candidates, preparation and distribution of assignment work, organization of seminar times, maintenance of Blackboard site, authoring of Honours handbook and selection of markers and committee members for thesis marking. Head of Discipline - Applied Sciences (2007- present): Responsibilities include; allocation of teaching load for FT staff, planning & maintenance of PT teaching budget, contracting of PT staff. School Working Party - redevelopment of B. Env. Sci. (2009-2010): Overseeing implementation of recommendations relating to B . Env. Sci. program. Coordinator - HSC Experimentfest (2004 - present). Planning and execution of Experimentfest operations at Ourimbah. Campus Administration " SAS Teaching Equipment Committee Representative (1996-1999). The committee was formed to manage & resource campus teaching space (e.g. projection facilities, internet). " Campus Computer Committee Representative (1996-1998). Formed to develop common policy with TAFE regarding computer hardware and software specifications for the Ourimbah campus. " Campus Policy Committee Alcohol Consumption (1997-1998). Formed to formulate a workable alcohol policy for a multi-sectorial campus. Faculty Administration " School Representative Faculty Quality Assurance Committee (2002-2003). Responsibilities included fortnightly attendance at meetings, collection and compilation of school-based data of relevance to the committee as directed by the Committee Chair. Faculty Representative Open Foundation External review committee (2005).

Collaborations
MB has a particular interest in how interactions between organic molecules act as signalling agents in both natural and synthetic systems. MB has established a successful collaborative research program with Emeritus Professor Ron Wills (Food Technology - Newcastle University) to develop new, environmentally friendly treatments for extending the postharvest life of selected farm produce using nitric oxide (NO) gas to delay senescence without the need for refrigeration. While the role of NO as a signalling agent in mammalian physiology is relatively well understood, its action in plants remains largely undefined. MB has utilised his skills as an organic chemist to synthesise a range of water soluble, zwitterionic NO donor compounds capable of delivering a known quantity of NO gas to produce in a controlled manner. Solid phase delivery of NO gas enhances the scope and flexibility of NO fumigation technology by eliminating the need for cumbersome and expensive infrastructure (e.g. cylinders and regulators). The research has to date yielded 4 refereed journal articles and competitive grant funding of $26.5K. MB has co-supervised two PhD completions and 1 Honours student associated with this work. MB has been extensively involved in molecular imprinting (MIP) research with Professor Adam McCluskey since 1999 and Dr Clovia Holdsworth since 2002. Initial research (99-01, $92000) supported by the Grape & Wine Research & Development Corporation (GWRDC) focused on the successful development of MIPs for the selective sensing of chloroarene contaminants in wine. These findings were reported in two peer-reviewed articles (Aust. J. Chem, 2004, 57, 759; Aust. J. Chem, 2006, 59, 129) and at domestic and international conferences including MIP2000 - The First Workshop on Molecular Imprinting, and Synthetic Receptors 2003 - The First World Congress on Synthetic Receptors (Lisbon, Portugal, October 13-15, 2003). MBs current research is supported by separate ARC Linkage Grants. Work conducted in conjunction with the Australian Federal Police ($190,000 & $51,000 industry component) seeks to develop novel MIP-based sensors for the selective identification of a number of illicit substances. Computational modelling protocols have been developed to improve MIP formulation and selectivity by pre-screening target molecules against a library of commercial functional monomers to identify and rank favourable interactions. These important outcomes were reported in 2005 (Aust. J. Chem, 2005, 58, 315). Attention is currently focused on the preparation of MIP-based films for the detection of narcotics and explosives using portable FTIR spectrophotometers for rapid, in-field assessment of suspected crime scenes. MB has successfully supervised 5 PhD completions and 7 Honours students. He currently co-supervises 4 RHD candidates.


Qualifications

  • PhD, University of New South Wales
  • Diploma in Education, University of New South Wales
  • Bachelor of Science (Honours), University of New South Wales

Keywords

  • General Chemistry
  • Heterocyclic Chemistry
  • Molecularly Imprinted Polymers
  • Nitric oxide releaseing agents
  • Organic Chemistry

Fields of Research

CodeDescriptionPercentage
030399Macromolecular and Materials Chemistry not elsewhere classified60
030499Medicinal and Biomolecular Chemistry not elsewhere classified25
090899Food Sciences not elsewhere classified15

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/07/2014 - Associate ProfessorUniversity of Newcastle
School of Environmental and Life Sciences
Australia

Academic appointment

DatesTitleOrganisation / Department
1/01/2005 - Lecturer University of Newcastle
School of Environmental and Life Sciences
Australia
1/01/1998 - 1/12/2005LecturerUniversity of Newcastle
School of Environmental and Life Sciences
Australia
1/01/1995 - 1/12/1997LecturerUniversity of Newcastle
School of Environmental and Life Sciences
Australia
1/01/1988 - 1/12/1992Academic The University of New South Wales
Australia

Awards

Recognition

YearAward
1999Dean's Award for Teaching Excellence - School of Science & Technology
University of Newcastle
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (3 outputs)

YearCitationAltmetricsLink
2015Bowyer MC, McCluskey A, Scarlett CJ, Vuong QV, 'Pancreatic Cancer drugs: Case Studies in Synthesis and Production', Plant Bioactive Compounds for Pancreatic Cancer Prevention and Treatment (Cancer Etiology, Diagnosis and Treatments), Nova Science Publishers, New York 145-193 (2015)
2015Scarlett CJ, Vuong QV, McCluskey A, Bowyer MC, 'Pancreatic Cancer Drugs: Case Studies in Synthesis and Production', Plant Bioactive Compounds for Pancreatic Cancer Prevention and Treatment, Nova Science Publishers , Inc., New York 145-193 (2015)
Co-authorsVanquan Vuong, C Scarlett, Adam Mccluskey
2011Booker KM, Holdsworth CI, Bowyer MC, McCluskey A, 'Ionic liquids as porogens in the synthesis of molecularly imprinted polymers', Applications of Ionic Liquids in Science and Technology, Intech, Croatia 197-212 (2011) [B1]
DOI10.5772/21725
Co-authorsAdam Mccluskey, Clovia Holdsworth

Journal article (40 outputs)

YearCitationAltmetricsLink
2015Vuong QV, Van TN, Dang TT, Bhuyan DJ, Goldsmith CD, Sadeqzadeh E, et al., 'Optimization of ultrasound-assisted extraction conditions for euphol from the medicinal plant, Euphorbia tirucalli, using response surface methodology', INDUSTRIAL CROPS AND PRODUCTS, 63 197-202 (2015)
DOI10.1016/j.indcrop.2014.09.057Author URL
Co-authorsVanquan Vuong, C Scarlett
2015Nguyen VT, Bowyer MC, Vuong QV, Altena IA, Scarlett CJ, 'Phytochemicals and antioxidant capacity of Xao tam phan (Paramignya trimera) root as affected by various solvents and extraction methods', Industrial Crops and Products, 67 192-200 (2015)

Xao tam phan (. Paramignya trimera (Oliv.) Guillaum) is a Vietnamese traditionally medicinal plant used in the treatment of numerous cancers. The preparation of Xao tam phan extracts including solvent type and extraction method have significant effects on extraction efficiency, phytochemical profile and biological activity. This study aimed to investigate the effects of five various solvents (water, acetonitrile, methanol, ethyl acetate and hexane) and three different extraction methods (conventional, ultrasound-assisted and microwave-assisted) on phytochemical yield and antioxidant capacity of P. trimera root from Vietnam. The results indicate that methanol extracted the maximal yield of phytochemicals from P. trimera and exhibited the greatest antioxidant capacity, with eleven compounds were identified and quantified. Microwave-assisted extraction produced the maximal phytochemical yields (except for total flavonoids) and antioxidant capacity, when compared to conventional and ultrasound-assisted extractions. These data reveal that the use of methanol and microwave-assisted extraction are recommended for extraction of biologically active phytochemicals from P. trimera root for application in the nutraceutical and/or pharmaceutical industries.

DOI10.1016/j.indcrop.2015.01.051
Co-authorsVanquan Vuong, C Scarlett
2015Vuong QV, Hirun S, Chuen TLK, Goldsmith CD, Murchie S, Bowyer MC, et al., 'Antioxidant and anticancer capacity of saponin-enriched Carica papaya leaf extracts', International Journal of Food Science and Technology, 50 169-177 (2015)

Summary: The papaya (Carica papaya) leaf (PL) contains high levels of saponins and polyphenolic compounds, and historically, it has been used as a folk medicine for numerous ailments, including cancer. PL is traditionally prepared by hot water extraction; however, optimised extraction conditions have not been assessed. This study optimised conditions for the extraction of saponins from PL and assessed their antioxidant capacity and antipancreatic cancer activity. Optimisation was achieved using response surface methodology. Saponins and total phenolic compounds were assessed for their antioxidant, free radical scavenging, ion-reducing capacity, and antipancreatic cancer activity. Optimal aqueous extraction conditions were 85 °C, 25 min. and a water-to-leaf ratio of 20:1 mL g-1. Ethanol extracts demonstrated higher antioxidant, free radical scavenging and ion-reducing capacity, as well as antipancreatic cancer activity. This study revealed that the PL contains numerous bioactive compounds, with significant anticancer activity warranting further studies on the isolation and characterisation of individual bioactive compounds from the PL.

DOI10.1111/ijfs.12618
Co-authorsVanquan Vuong, C Scarlett
2015Vuong QV, Hirun S, Chuen TLK, Goldsmith CD, Munro B, Bowyer MC, et al., 'Physicochemical, antioxidant and anti-cancer activity of a Eucalyptus robusta (Sm.) leaf aqueous extract', INDUSTRIAL CROPS AND PRODUCTS, 64 167-174 (2015)
DOI10.1016/j.indcrop.2014.10.061Author URL
Co-authorsAnita Chalmers, Vanquan Vuong, C Scarlett, Jennette Sakoff
2015Vuong QV, Hirun S, Chuen TLK, Goldsmith CD, Murchie S, Bowyer MC, et al., 'Antioxidant and anticancer capacity of saponin-enriched Carica papaya leaf extracts', INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY, 50 169-177 (2015)
DOI10.1111/ijfs.12618Author URL
Co-authorsC Scarlett, Vanquan Vuong
2015Bhuyan DJ, Quan VV, Chalmers AC, van Altena IA, Bowyer MC, Scarlett CJ, 'Microwave-assisted extraction of Eucalyptus robusta leaf for the optimal yield of total phenolic compounds', INDUSTRIAL CROPS AND PRODUCTS, 69 290-299 (2015)
DOI10.1016/j.indcrop.2015.02.044Author URL
Co-authorsC Scarlett, Anita Chalmers, Vanquan Vuong
2015Nguyen VT, Van Vuong Q, Bowyer MC, Van Altena IA, Scarlett CJ, 'Effects of Different Drying Methods on Bioactive Compound Yield and Antioxidant Capacity of Phyllanthus amarus', Drying Technology, 33 1006-1017 (2015)

Phyllanthus amarus (P. amarus) has been used as a herbal medicine, particularly for liver support, in many countries and its extracts have been shown to possess potent antioxidant and anticancer properties in vitro. The preparation of dried sample is crucial for further extraction and isolation of phytochemicals. In this study, the effects of six different drying methods (hot air, low-temperature air, infrared, microwave, sun, and vacuum drying) on the phytochemical yield and antioxidant capacity were determined to identify the optimal drying method for P. amarus. The results showed that different drying methods, as well as different drying conditions within each method, significantly affected phytochemical yield and antioxidant capacity of P. amarus extracts. Infrared drying at 30°C was the best method for both retention of bioactive compound yield and antioxidant capacity of P. amarus extract, with 12 compounds were identified. In contrast, low-temperature-air drying at 25°C not only required the longest drying time but also significantly reduced the levels of bioactive compounds and antioxidant capacity of P. amarus. Therefore, infrared drying at 30°C is suggested for drying P. amarus for subsequent assessment of bioactivity.

DOI10.1080/07373937.2015.1013197
Co-authorsVanquan Vuong, C Scarlett
2015Vuong QV, Zammit N, Munro BR, Murchie S, Bowyer MC, Scarlett CJ, 'Effect of drying conditions on physicochemical and antioxidant properties of vitex agnus-castus leaves', Journal of Food Processing and Preservation, (2015)

Vitex agnus-castus (VitexAC) leaves have been used for medicinal purposes for many years. Drying is important to prepare starting materials for further processing, as it is associated with production cost and quality of the materials. Herein, the effects of five different drying conditions on the physical, chemical and antioxidant properties of VitexAC were evaluated. The results showed that 30% of dried leaves with moisture content of less than 7% could be produced from fresh leaves. VitexAC leaves dried by freeze and vacuum drying at 65C had higher levels of bioactive compounds as well as higher antioxidant capacity in comparison with other drying conditions, revealing that these drying conditions are more suitable for drying VitexAC leaves. However, freeze drying is costly and time-consuming; thus, vacuum drying at 65C is suggested for drying the VitexAC leaves as the starting materials for further processing steps. Practical Applications: As drying is an important process to prepare starting materials for further processing steps, it is important to compare different drying methods to identify the most suitable method with low cost and less effect on material quality. The results showed that inappropriate drying conditions resulted in big loss of bioactive compounds and antioxidant capacity. Vacuum drying at 65C was found to be the most suitable method, which can be easily applied for drying Vitex agnus-castus leaves in the industrial scale.

DOI10.1111/jfpp.12506
Co-authorsC Scarlett, Vanquan Vuong
2015Vuong QV, Chalmers AC, Jyoti Bhuyan D, Bowyer MC, Scarlett CJ, 'Botanical, Phytochemical, and Anticancer Properties of the Eucalyptus Species.', Chem Biodivers, 12 907-924 (2015)
DOI10.1002/cbdv.201400327Author URL
Co-authorsAnita Chalmers, C Scarlett, Vanquan Vuong
2014Zayas H, Holdsworth CI, Bowyer MC, McCluskey A, 'Evaluation of 4-substituted styrenes as functional monomers for the synthesis of theophylline-specific molecularly imprinted polymers.', Org Biomol Chem, 12 6994-7003 (2014) [C1]
DOI10.1039/c4ob00517aAuthor URL
Co-authorsClovia Holdsworth, Adam Mccluskey
2014Vuong QV, Hirun S, Phillips PA, Chuen TLK, Bowyer MC, Goldsmith CD, Scarlett CJ, 'Fruit-derived phenolic compounds and pancreatic cancer: Perspectives from Australian native fruits', JOURNAL OF ETHNOPHARMACOLOGY, 152 227-242 (2014) [C1]
DOI10.1016/j.jep.2013.12.023Author URL
CitationsScopus - 2Web of Science - 2
Co-authorsVanquan Vuong, C Scarlett
2014Booker K, Holdsworth CI, Doherty CM, Hill AJ, Bowyer MC, McCluskey A, 'Ionic liquids as porogens for molecularly imprinted polymers: Propranolol, a model study', Organic and Biomolecular Chemistry, 12 7201-7210 (2014) [C1]

The selectivity and rebinding capacity of molecularly imprinted polymers selective for propranolol (1) using the room temperature ionic liquids [BMIM][BF4], [BMIM][PF6], [HMIM][PF6] and [OMIM][PF6] and CHCl3 were examined. The observed IF (imprinting factor) values for MIPBF4, MIPPF6 and MIP CHCl3 were 1.0, 1.98 and 4.64, respectively. The longer chain HMIM and OMIM systems returned lower IF values of 1.1 and 2.3, respectively. MIP PF6 also showed a ~25% binding capacity reduction vs. MIP CHCl3 (5 µmol g-1vs. 7 µmol g-1 respectively). MIPCHCl3 and MIPPF6 differed in terms of BET surface area (306 m2 g-1vs. 185 m2 g -1), pore size (1.10 and 2.19 nm vs. 0.97 and 7.06 nm), the relative number of pores (Type A: 10.4 vs. 7.5%; Type B: 8.5 vs. 3.0%), and surface zeta potential (-37.9 mV vs. -20.3 mV). The MIP specificity for 1 was examined by selective rebinding studies with caffeine (2) and ephedrine (3). MIP PF6 rebound higher quantities of 2 than MIPCHCl3, but this was largely due to non-specific binding. Both MIPCHCl3 and MIP PF6 showed a higher affinity for 3 than for 2. Reduction in the Room Temperature Ionic Liquid (RTIL) porogen volume had little impact on the polymer morphology, but did result in a modest decrease in IF from 2.6 to 2.3 and in the binding capacity (30% to 19%). MIPCHCl3 retained the highest template specificity on rebinding from CHCl3 (IF = 4.6) dropping to IF = 0.6 in MeOH/[BMIM][PF6]. The MIPCHCl3 binding capacity remained constant using CHCl3, CH2Cl2 and MeOH (46-52%), dropped to 6% on addition of [BMIM][PF6] and increased to 83% in H2O (but at the expense of specificity with IFH2O = 1.4). MIPPF6 rebinding from MeOH saw an increase in specific rebinding to IF = 4.9 and also an increase in binding capacity to 48% when rebinding 1 from MeOH and to 42% and 45% with H2O and CH2Cl2, respectively, although in the latter case the increased capacity was at the cost of specificity with IFCH2Cl2 = 1.2. Overall the MIPPF6 capacity and specificity were enhanced on addition of MeOH. This journal is © the Partner Organisations 2014.

DOI10.1039/c4ob00547c
CitationsScopus - 1Web of Science - 1
Co-authorsAdam Mccluskey, Clovia Holdsworth
2014Vuong QV, Sadeqzadeh E, Hirun S, Goldsmith CD, Zammitt N, Bowyer MB, et al., 'Phenolic Compounds, Antioxidant and Anti-Cancer Properties of the Australian Maroon Bush Scaevola spinescens (Goodeniaceae)', Journal of Bioanalysis & Biomedicine, S12 (2014) [C1]
DOI10.4172/1948-593X.S12-002
Co-authorsJudith Weidenhofer, Vanquan Vuong, Rick Thorne, Jennette Sakoff, C Scarlett
2014Vuong QV, Hirun S, Chuen TLK, Goldsmith CD, Bowyer MC, Chalmers AC, et al., 'Physicochemical composition, antioxidant and anti-proliferative capacity of a lilly pilly (Syzygium paniculatum) extract', JOURNAL OF HERBAL MEDICINE, 4 134-140 (2014)
DOI10.1016/j.hermed.2014.04.003Author URL
CitationsWeb of Science - 1
Co-authorsVanquan Vuong, C Scarlett, Anita Chalmers
2014Vuong QV, Hirun S, Chuen TLK, Goldsmith CD, Bowyer MC, Chalmers AC, et al., 'Physicochemical composition, antioxidant and anti-proliferative capacity of a lilly pilly (Syzygium paniculatum) extract', Journal of Herbal Medicine, 4 134-140 (2014) [C1]

Lilly pilly (LP) fruit (Syzygium paniculatum Gaertn.) is widely grown in eastern Australia and has been used as food by indigenous Australians. However, there is limited information on its bioactivity. This study investigated the physicochemical and antioxidant properties of the crude fruit extract, identified its bioactive compounds and also assessed its potential anti-proliferative effect on pancreatic cancer cells. Our data showed that the LP extract was water-soluble and possessed a total phenolic content of 96 mg of gallic acid equivalents (GAE)/g, flavonoid levels of 52 mg catechin equivalents (CAE)/g, proanthocyanidin levels of 29 mg CAE/g. Several phenolic compounds such as gallic acid, chlorogenic acid, catechin and epicatechin were identified in the LP extract with levels of 0.39, 2.35, 0.47 and 2.9 mg/g, respectively. Results from six different antioxidant assays revealed that the LP extract pocessed potent antioxidant and free radical scavenging capacity. Although antioxidant capacity of the extract was lower than that of vitamin E, vitamin C and BHT, it could be significantly improved if the extract was to be further purified. We also showed that the LP extract (200 µg/mL) significantly reduced the viability of MiaPaCa-2 and ASPC-1 pancreatic cancer cells to levels comparable to that of the chemotherapeutic agent gemcitabine. For this reason lilly pilly should be further investigated for its health promoting and potential anti-cancer benefits, particularly for pancreatic cancer. © 2014 Elsevier GmbH.

DOI10.1016/j.hermed.2014.04.003
Co-authorsAnita Chalmers, C Scarlett, Vanquan Vuong
2014Vuong Q, Goldsmith C, Dang T, Nguyen V, Bhuyan D, Sadeqzadeh E, et al., 'Optimisation of Ultrasound-Assisted Extraction Conditions for Phenolic Content and Antioxidant Capacity from Euphorbia tirucalli Using Response Surface Methodology', Antioxidants, 3 604-617 (2014) [C1]
DOI10.3390/antiox3030604
Co-authorsVanquan Vuong, C Scarlett
2013Brisbane C, McCluskey A, Bowyer M, Holdsworth CI, 'Molecularly imprinted films of acrylonitrile/methyl methacrylate/acrylic acid terpolymers: influence of methyl methacrylate in the binding performance of L-ephedrine imprinted films', Organic & Biomolecular Chemistry, 11 2872-2884 (2013) [C1]
DOI10.1039/c3ob40332gAuthor URL
CitationsScopus - 1Web of Science - 1
Co-authorsClovia Holdsworth, Adam Mccluskey
2013Vuong QV, Hirun S, Roach PD, Bowyer MC, Phillips PA, Scarlett CJ, 'Effect of extraction conditions on total phenolic compounds and antioxidant activities of Carica papaya leaf aqueous extracts', JOURNAL OF HERBAL MEDICINE, 3 104-111 (2013) [C1]
DOI10.1016/j.hermed.2013.04.004Author URL
CitationsScopus - 8Web of Science - 9
Co-authorsC Scarlett, Vanquan Vuong, Paul Roach
2012Turner NW, Holdsworth CI, McCluskey A, Bowyer MC, 'N-2-propenyl-(5-dimethylamino)-1-naphthalene sulfonamide, a novel fluorescent monomer for the molecularly imprinted polymer-based detection of 2,4-dinitrotoluene in the gas phase', Australian Journal of Chemistry, 65 1405-1412 (2012) [C1]
CitationsScopus - 3Web of Science - 3
Co-authorsAdam Mccluskey, Clovia Holdsworth
2011Vuong QV, Bowyer MC, Roach PD, 'L-Theanine: Properties, synthesis and isolation from tea', Journal of the Science of Food and Agriculture, 91 1931-1939 (2011) [C1]
DOI10.1002/jsfa.4373
CitationsScopus - 29Web of Science - 24
Co-authorsVanquan Vuong, Paul Roach
2010Turner NW, Holdsworth CI, Donne SW, McCluskey A, Bowyer MC, 'Microwave induced MIP synthesis: comparative analysis of thermal and microwave induced polymerisation of caffeine imprinted polymers', New Journal of Chemistry, 34 686-692 (2010) [C1]
DOI10.1039/b9nj00538b
CitationsScopus - 21Web of Science - 18
Co-authorsAdam Mccluskey, Clovia Holdsworth, Scott Donne
2009Turner NW, Holmes NP, Brisbane CE, McGeachie AB, Bowyer MC, McCluskey A, Holdsworth CI, 'Effect of template on the formation of phase-inversed molecularly imprinted polymer thin films: An assessment', Soft Matter, 5 3663-3671 (2009) [C1]
DOI10.1039/b902468a
CitationsScopus - 6Web of Science - 5
Co-authorsClovia Holdsworth, Adam Mccluskey
2009Zayas HA, Bowyer MC, Gordon CP, Holdsworth CI, McCluskey A, 'Synthesis of biaryl-styrene monomers by microwave-assisted Suzuki coupling', Tetrahedron Letters, 50 5894-5895 (2009) [C1]
DOI10.1016/j.tetlet.2009.07.117
CitationsScopus - 9Web of Science - 8
Co-authorsAdam Mccluskey, Clovia Holdsworth
2007Wills RB, Soegiarto L, Bowyer MC, 'Use of a solid mixture containing diethylenetriamine/nitric oxide (DETANO) to liberate nitric oxide gas in the presence of horticultural produce to extend postharvest life', Nitric Oxide - Biology and Chemistry, 17 44-49 (2007) [C1]
DOI10.1016/j.niox.2007.05.003
CitationsScopus - 17Web of Science - 16
Co-authorsRon Wills
2007McCluskey A, Holdsworth CI, Bowyer MC, 'Molecularly imprinted polymers (MIPs): sensing, an explosive new opportunity?', Organic & Biomolecular Chemistry, 5 3233-3244 (2007) [C1]
DOI10.1039/b708660a
CitationsScopus - 48Web of Science - 45
Co-authorsClovia Holdsworth, Adam Mccluskey
2007Booker KM, Bowyer MC, Lennard CJ, Holdsworth CI, McCluskey A, 'Molecularly imprinted polymers and room temperature ionic liquids: Impact of template on polymer morphology', Australian Journal of Chemistry, 60 51-56 (2007) [C1]
DOI10.1071/ch06284
CitationsScopus - 16Web of Science - 15
Co-authorsAdam Mccluskey, Clovia Holdsworth
2006Booker KM, Bowyer MC, Holdsworth CI, McCluskey A, 'Efficient preparation and improved sensitivity of molecularly imprinted polymers using room temperature ionic liquids', Chemical Communications, 1730-1732 (2006) [C1]
DOI10.1039/b517886j
CitationsScopus - 31Web of Science - 31
Co-authorsClovia Holdsworth, Adam Mccluskey
2006Snowdon EM, Bowyer MC, Grbin PR, Bowyer PK, 'Mousy off-flavor: A review', Journal of Agricultural and Food Chemistry, 54 6465-6474 (2006) [C1]
DOI10.1021/jf0528613
CitationsScopus - 47Web of Science - 39
2006Schwarz LJ, Bowyer MC, Holdsworth CI, McCluskey A, 'Synthesis and evaluation of a molecularly imprinted polymer selective to 2,4,6-trichloroanisole', Australian Journal of Chemistry, 59 129-134 (2006) [C1]
DOI10.1071/CH05318
CitationsScopus - 19Web of Science - 18
Co-authorsClovia Holdsworth, Adam Mccluskey
2005Holdsworth CI, Bowyer MC, Lennard C, McCluskey A, 'Formulation of cocaine-imprinted polymers utilizing molecular modelling and NMR analysis', Australian Journal of Chemistry, 58 315-320 (2005) [C1]
DOI10.1071/CH04138
CitationsScopus - 24Web of Science - 24
Co-authorsAdam Mccluskey, Clovia Holdsworth
2004Schwarz LJ, Holdsworth CI, McCluskey A, Bowyer MC, 'Synthesis and Evaluation of a Molecularly Imprinted Polymer Selective to 2,4,6-Trichlorophenol', Australian Journal of Chemistry, 57 759-764 (2004) [C1]
DOI10.1071/CH04004
CitationsScopus - 30Web of Science - 31
Co-authorsClovia Holdsworth, Adam Mccluskey
2004Bowyer MC, Gordon CM, Leitch SK, McCluskey A, Ritchie C, 'Indium-Mediated Addition of 4-Bromocrotonic Acid to Aldehydes and Ketones - A Simple, High Yielding Route to Alpha-Allyl-Beta-Hydroxy Carboxylic Acids', Australian Journal of Chemistry: an international journal for chemical science, 57 135-137 (2004) [C1]
DOI10.1071/CH03212
CitationsScopus - 5Web of Science - 4
Co-authorsAdam Mccluskey
2004Badiyan D, Wills RB, Bowyer MC, 'Use of a nitric oxide donor compound to extend the vase life of cut flowers', Hortscience, 39 1371-1372 (2004) [C1]
CitationsScopus - 10Web of Science - 10
Co-authorsRon Wills
2004McCluskey A, Bowyer MC, 'Synthetic antibodies and the Australian wine industry: A Hunter Valley solution to cork taint?', Australian & New Zealand Grapegrower & Winemaker, 2004 111-115 (2004) [C3]
Co-authorsAdam Mccluskey
2003Ackland S, Bowyer MC, Baldwin ML, Garner JA, Walkom CC, Sakoff JA, McCluskey A, 'Cantharidin analogues: synthesis and evaluation of growth inhibition in a panel of selected tumour cell lines', Bioorganic Chemistry, 31 68-79 (2003) [C1]
DOI10.1016/S0045-2068(02)00524-2
CitationsScopus - 72Web of Science - 61
Co-authorsAdam Mccluskey, Stephen Ackland, Jennette Sakoff
2003Bowyer MC, Wills RB, Badiyan D, Ku VV-V, 'Extending the postharvest life of carnations with nitric oxide - comparison of fumigation and in vivo delivery', Postharvest Biology and Technology, 30 281-286 (2003) [C1]
DOI10.1016/S0925-5214(03)00114-5
CitationsScopus - 34Web of Science - 32
Co-authorsRon Wills
2002McCluskey A, Atherton MA, Walkom CC, Bowyer M, Sim A, Young D, Sakoff J, 'The first two cantharidin analogues displaying PP1 selectivity', Bioorganic & Medicinal Chemistry Letters, 12 391-393 (2002) [C1]
CitationsScopus - 39Web of Science - 38
Co-authorsAdam Mccluskey, Mirella Atherton, Jennette Sakoff, Alistair Sim
2001McCluskey A, Walkom CC, Bowyer MC, Ackland SP, Gardiner E, Sakoff JA, 'Cantharimides: A new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A', Bioorganic & Medicinal Chemistry Letters, 11 2941-2946 (2001) [C1]
CitationsScopus - 55Web of Science - 55
Co-authorsAdam Mccluskey, Stephen Ackland, Jennette Sakoff
2000Keane MA, Bowyer MC, Biggs SR, Galvin KP, Hosken RW, 'Particle size analysis of microfluidised dairy emulsions', AUSTRALIAN JOURNAL OF DAIRY TECHNOLOGY, 55 94-94 (2000)
Author URL
Co-authorsKevin Galvin
2000Bowyer MC, 'Anhydride Modified Cantharidin Analogues: Synthesis, Inhibition of Protein Phosphatases 1 and 2A and Anticancer Activity', Bioorganic & Medicinal Chemistry Letters, 10 1687-1690 (2000) [C1]
CitationsScopus - 69Web of Science - 69
Co-authorsAdam Mccluskey, Alistair Sim, Jennette Sakoff
Show 37 more journal articles

Conference (11 outputs)

YearCitationAltmetricsLink
2014Sadeqzadeh E, Vuong QV, Goldsmith CD, Nguyen VT, Bhuyan DJ, Trung TD, et al., 'A NATURAL PRODUCT DRUG DISCOVERY PIPELINE FOR NOVEL PANCREATIC CANCER THERAPIES: A NEW CANCER RESEARCH HUB FOR THE HUNTER REGION OF NSW', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
Author URL
Co-authorsNatalie Moltschaniwskyj, C Scarlett, Rick Thorne, Judith Weidenhofer, Vanquan Vuong, Anita Chalmers, Troy Gaston
2013Holdsworth CI, Diah A, Romano E, Mahinay D, Quirino J, Holdsworth J, Bowyer M, 'Characterisation of Functional Polymeric Materials by Capillary Electrophoresis', Abstracts, 2nd International Congress on Advanced Materials (AM2013), Zhenjiang, China (2013) [E3]
Co-authorsClovia Holdsworth, John Holdsworth
2013Holdsworth CI, Diah A, Romano E, Mahinay D, Quirino J, Holdsworth J, Bowyer M, 'Characterisation of Functional Polymeric Materials by Capillary Electrophoresis', Abstracts, 2nd International Congress on Advanced Materials (AM2013), Zhenjiang, China (2013) [E3]
Co-authorsClovia Holdsworth, John Holdsworth
2003Wills RB, Bowyer MC, Leshem Y, 'Use of Nitric Oxide to Extend the Postharvest Life of Horticultural Produce', Acta Horticulturae, Leuven, Belgium (2003) [E1]
CitationsScopus - 1
Co-authorsRon Wills
2002Wills RB, Bowyer MC, 'Use of Nitric Oxide to Extend the Postharvest Life of Flowers', The Wildflower Business: Keys to Progress and Profit, Warwick Farm, Sydney, NSW, Australia (2002) [E2]
Co-authorsRon Wills
2000Keane MA, Bowyer MC, Hosken RW, 'Relationship Between Particle Size and Creaminess in Microfluidized Low Fat Dairy Emulsions', CHEMECA 2000, Perth, AUSTRALIA (2000) [E1]
1999Keane MA, McMillan W, Bowyer MC, Galvin KP, Biggs S, Hosken RW, 'Microsctructure and sensory investigation of frozen deserts containing pectin', 10th World COngress of Food Science & Technology Abstracts, Sydney, Australia (1999) [E3]
Co-authorsKevin Galvin
1999Keane MA, McMillan W, Nada GGAS, Bowyer MC, Galvin K, Biggs S, Hosken RW, 'Relation of particle size and sensory characteristics of Microfluidized reduced fat ice cream', 10th World Congress of Food Science and Technology Abstracts, Sydney, Australia (1999) [E3]
1999Keane MA, McMillan W, Bowyer MC, Galvin K, Biggs S, Hosken RW, 'Laser Scanning Confocal Microscopy of a Dairy Based Emulsion', Chemeca 99, Newcastle, Australia (1999) [E1]
1999Keane MA, Heenan CN, Bowyer MC, Hosken RW, 'Application of Inulin as a Fat Replacer in Dairy Foods', Proceedings of the Nutrition Society of Australia, Auckland, New Zealand (1999) [E3]
1998Keane MA, Bowyer MC, Hosken RW, 'Acceptance of a low fat dairy desert by adolescents', Proceedings of the Nutrition Society, Adelaide November 29 1998 (1998) [E1]
Show 8 more conferences
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Grants and Funding

Summary

Number of grants24
Total funding$3,477,269

Click on a grant title below to expand the full details for that specific grant.


20145 grants / $2,290,372

Food & Beverage Supply Chain Optimisation Industrial Transformation Training Centre$2,119,872

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Rick Middleton, Associate Professor Regina Berretta, Associate Professor Michael Bowyer, Doctor Ali Eshragh, Doctor Christopher Scarlett, Doctor Masoud Talebian, Associate Professor Behnam Fahimnia, Professor Mathieu Savelsbergh, Professor Natashia Boland, Dr Costas Stathopoulos, Professor John Bartholdi, Doctor John Golding, Doctor Simon Dunstall, Mrs Carlee McGowan, Mr Robert McMahon, Mr Robert Scoines, Mr Tim Norris
SchemeIndustrial Transformation Training Centres
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301004
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Food & Beverage Supply Chain Optimisation Industrial Transformation Training Centre$90,000

Funding body: Coca Cola Amatil (Australia)

Funding bodyCoca Cola Amatil (Australia)
Project TeamProfessor Rick Middleton, Associate Professor Regina Berretta, Associate Professor Michael Bowyer, Doctor Ali Eshragh, Doctor Christopher Scarlett, Doctor Masoud Talebian, Associate Professor Behnam Fahimnia, Professor Mathieu Savelsbergh, Professor Natashia Boland, Dr Costas Stathopoulos, Professor John Bartholdi, Doctor John Golding, Doctor Simon Dunstall, Mrs Carlee McGowan, Mr Robert McMahon, Mr Robert Scoines, Mr Tim Norris
SchemeARC IC Partner Funding
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301129
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Food & Beverage Supply Chain Optimisation Industrial Transformation Training Centre$30,000

Funding body: Sanitarium Health and Wellbeing Company

Funding bodySanitarium Health and Wellbeing Company
Project TeamProfessor Rick Middleton, Associate Professor Regina Berretta, Associate Professor Michael Bowyer, Doctor Ali Eshragh, Doctor Christopher Scarlett, Doctor Masoud Talebian, Associate Professor Behnam Fahimnia, Professor Mathieu Savelsbergh, Professor Natashia Boland, Dr Costas Stathopoulos, Professor John Bartholdi, Doctor John Golding, Doctor Simon Dunstall, Mrs Carlee McGowan, Mr Robert McMahon, Mr Robert Scoines, Mr Tim Norris
SchemeARC IC Partner Funding
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301130
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Food & Beverage Supply Chain Optimisation Industrial Transformation Training Centre$30,000

Funding body: Sunrice

Funding bodySunrice
Project TeamProfessor Rick Middleton, Associate Professor Regina Berretta, Associate Professor Michael Bowyer, Doctor Ali Eshragh, Doctor Christopher Scarlett, Doctor Masoud Talebian, Associate Professor Behnam Fahimnia, Professor Mathieu Savelsbergh, Professor Natashia Boland, Dr Costas Stathopoulos, Professor John Bartholdi, Doctor John Golding, Doctor Simon Dunstall, Mrs Carlee McGowan, Mr Robert McMahon, Mr Robert Scoines, Mr Tim Norris
SchemeARC IC Partner Funding
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301131
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Identification and evaluation of anti-pancreatic cancer activity of cytotoxic compounds extracted from Australian sea sponges: a pilot study$20,500

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Christopher Scarlett, Doctor Quan Vuong, Doctor Jude Weidenhofer, Doctor Rick Thorne, Associate Professor Michael Bowyer, Doctor Troy Gaston
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1401452
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20121 grants / $15,000

2011 Emerging Research Leaders Program$15,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Michael Bowyer
SchemeEmerging Research Leaders Program
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200620
Type Of FundingInternal
CategoryINTE
UONY

20081 grants / $1,740

The Fifth International Workship on Molecular Imprinting (MIP 2008), Kobe, Japan, 7/9/2008 - 11/9/2008$1,740

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Michael Bowyer
SchemeTravel Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0189036
Type Of FundingInternal
CategoryINTE
UONY

20073 grants / $588,942

Chemical listening devices: Novel sensors targeting the clandestine manufacture and transport of illicit drugs and explosives$378,942

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Adam McCluskey, Associate Professor Michael Bowyer, Doctor Clovia Holdsworth, Professor Christopher Lennard
SchemeLinkage Projects
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0186611
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Chemical listening devices: Novel sensors targeting the clandestine manufacture and transport of illicit drugs and explosives$105,000

Funding body: Australian Federal Police

Funding bodyAustralian Federal Police
Project TeamProfessor Adam McCluskey, Associate Professor Michael Bowyer, Doctor Clovia Holdsworth, Professor Christopher Lennard
SchemeLinkage Projects Partner funding
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187330
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Selective Detection and Removal of Organochlorine Residues via MIPs$105,000

Funding body: Entech Industries Pty Ltd

Funding bodyEntech Industries Pty Ltd
Project TeamProfessor Adam McCluskey, Doctor Clovia Holdsworth, Associate Professor Michael Bowyer
SchemePostgraduate Research Scholarship
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187721
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20061 grants / $1,500

MIP 2006 - 4th International Workshop on Molecularly Imprinted Polymers, Cardiff Wales, 10-14 September 2006$1,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Michael Bowyer
SchemeTravel Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186777
Type Of FundingInternal
CategoryINTE
UONY

20044 grants / $457,336

Selective detection and removal of contaminants that have an adverse impact on Australian raw sugar quality$190,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Adam McCluskey, Associate Professor Michael Bowyer, Dr M O'Shea
SchemeLinkage Projects
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183626
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

In-field sensors for the detection of illicit drugs$171,336

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Adam McCluskey, Associate Professor Michael Bowyer
SchemeLinkage Projects
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0184254
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Selective detection and removal of contaminants that have adverse impact on Australian raw sugar quality$51,000

Funding body: Bureau of Sugar Experiment Stations

Funding bodyBureau of Sugar Experiment Stations
Project TeamProfessor Adam McCluskey, Associate Professor Michael Bowyer
SchemeLinkage Projects Partner funding
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0184030
Type Of FundingNot Known
CategoryUNKN
UONY

In-field sensors for the detection of illicit drugs$45,000

Funding body: Australian Federal Police

Funding bodyAustralian Federal Police
Project TeamProfessor Adam McCluskey, Associate Professor Michael Bowyer
SchemeLinkage Projects Partner funding
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0185067
Type Of FundingNot Known
CategoryUNKN
UONY

20031 grants / $750

Synthetic Receptors - 2003, The first World Congress on Synthetic Receptors Lisbon, Portugal 15-17 October 2003$750

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Michael Bowyer
SchemeTravel Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0183233
Type Of FundingInternal
CategoryINTE
UONY

20022 grants / $58,000

Delaying postharvest senescence of cut flowers using nitric oxide.$50,000

Funding body: Rural Industries Research & Development Corporation

Funding bodyRural Industries Research & Development Corporation
Project TeamEmeritus Professor Ronald Wills, Associate Professor Michael Bowyer
SchemeResearch and Development Project
RoleInvestigator
Funding Start2002
Funding Finish2002
GNoG0182218
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Endogenous Application of Nitric Oxide to Postharvest Horticultural Produce to Delay Senescence$8,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Michael Bowyer
SchemeProject Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181387
Type Of FundingInternal
CategoryINTE
UONY

20002 grants / $28,708

Selective detection of Trichloroanisole and other flavour contaminants in wines using molecularly imprinted polymer technology.$26,950

Funding body: Grape & Wine Research and Development Corporation

Funding bodyGrape & Wine Research and Development Corporation
Project TeamProfessor Adam McCluskey, Associate Professor Michael Bowyer
SchemeProject Grant
RoleInvestigator
Funding Start2000
Funding Finish2000
GNoG0180158
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

MIP 2000, 3 - 5 July 2000.$1,758

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Michael Bowyer
SchemeTravel Grant
RoleLead
Funding Start2000
Funding Finish2000
GNoG0179775
Type Of FundingInternal
CategoryINTE
UONY

19992 grants / $20,421

Selective detection of Trichloroanisole and other flavour contaminants in wines using molecularly imprinted polymer technology$20,000

Funding body: Grape & Wine Research and Development Corporation

Funding bodyGrape & Wine Research and Development Corporation
Project TeamProfessor Adam McCluskey, Associate Professor Michael Bowyer
SchemeProject Grant
RoleInvestigator
Funding Start1999
Funding Finish1999
GNoG0178612
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Inorganic Chemistry '99. Wellington, New Zealand. 31 January - 4 February, 1999$421

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Michael Bowyer
SchemeTravel Grant
RoleLead
Funding Start1999
Funding Finish1999
GNoG0179106
Type Of FundingInternal
CategoryINTE
UONY

19971 grants / $4,500

Stereoselective synthesis of alkanamides from echinacea$4,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Michael Bowyer
SchemeProject Grant
RoleLead
Funding Start1997
Funding Finish1997
GNoG0176749
Type Of FundingInternal
CategoryINTE
UONY

19951 grants / $10,000

Synthesis of Indole Analogues of ISoflavonoid Phytoestrogens.$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Michael Bowyer
SchemeNew Staff Grant
RoleLead
Funding Start1995
Funding Finish1995
GNoG0176053
Type Of FundingInternal
CategoryINTE
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Anticancer Compounds from Plants Against Pancreatic Cancer Cells: Extraction, Purification and Characterization
Food Science & Biotechnology, Faculty of Science and Information Technology
Co-Supervisor
2014Regulation of Postharvest Leaf Senescence by Endogenous Nitric Oxide
Food Science & Biotechnology, Faculty of Science and Information Technology
Co-Supervisor
2014Brown Algae as a Source of Bioactive Compounds for Pancreatic Cancer Treatment
Food Science & Biotechnology, Faculty of Science and Information Technology
Co-Supervisor
2014Bioactive Compounds, Antioxidant and Anti-Pancreatic Cancer Capacity of Two Vietnamese Medicinal Plants: Phyllanthus Amarus and Paramignya Trimera
Food Science & Biotechnology, Faculty of Science and Information Technology
Co-Supervisor
2014Phytochemicals Derived From Australian Eucalypts as Anticancer Agents for Pancreatic Malignancies
Food Science & Biotechnology, Faculty of Science and Information Technology
Co-Supervisor
2014Postharvest Energy Reduction Through Atmosphere Control of Fruit and Vegetable During Storage and Transport
Food Science & Biotechnology, Faculty of Science and Information Technology
Co-Supervisor
2013Mechanistic Aspects of Molecular Imprinting: Effects on Binding Performance
Chemical Sciences, Faculty of Science and Information Technology
Co-Supervisor
2011Factors Influencing the Physiological and Perceptual Decision-Making Demands of Australian Football Field Umpires
Human Movement, Faculty of Science and Information Technology
Co-Supervisor
2005Use of nitric oxide in extending the postharvest life of flowers & green vegetables
Food Science & Biotechnology, University of Newcastle
Principal Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2014Exploring Signal Transduction Mechanisms in Molecularly Imprinted Polymers for Forensic Applications
Chemical Sciences, Faculty of Science and Information Technology
Co-Supervisor
2014The Use of Game-Based Training to Provide a Match-Specific Environment for Cricket Players
Human Movement, Faculty of Science and Information Technology
Co-Supervisor
2012Development of Molecularly Imprinted Polymers for Amphetamine Type Substance Recognition in Aqueous Environments
Chemical Sciences, Faculty of Science and Information Technology
Sole Supervisor
2012Synthesis, Characterisation and Evaluation of Biphenyl Monomers for Molecular Imprinting Applications
Chemical Sciences, Faculty of Science and Information Technology
Co-Supervisor
2010Towards the Development of a Benzylpiperazine Specific Molecular Imprinted Polymer
Chemical Sciences, Faculty of Science and Information Technology
Co-Supervisor
2010Optimisation of Molecularly Imprinted Polymeric Films for the Detection of L-Ephedrine
Chemical Sciences, Faculty of Science and Information Technology
Co-Supervisor
2010Characterisation and Improved Performance of Molecularly Imprinted Polymers Prepared Using Room Temperature Ionic Liquids
Chemical Sciences, Faculty of Science and Information Technology
Co-Supervisor
2009Comparative Effects of Nitric Oxide Gas and Nitric Oxide Donors on the Postharvest Life of Cut Flowers and Brassica Vegetables
Food Science & Biotechnology, Faculty of Science and Information Technology
Principal Supervisor
2009Synthesis of 3,7-Diazabicyclo[3.3.1]nonan-9-ones as Potential Enantioselective Group Transfer Catalysts
Chemical Sciences, Faculty of Science and Information Technology
Principal Supervisor
2008Design and Synthesis of Molecularly Imprinted Polymers for the Selective Recognition of Small Chloro-Arene Contaminants
Chemical Sciences, Faculty of Science and Information Technology
Co-Supervisor
2006Extending the postharvest life of ornamentals using the nitric oxide donor compound, 2, 2¿- (hydroxynitrosohydrazino)-bisethanamine
Food Science & Biotechnology, Faculty of Science and Information Technology
Co-Supervisor
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Associate Professor Michael Bowyer

Position

Deputy Head of Faculty
Deputy Head - Faculty of Science & IT
School of Environmental and Life Sciences
Faculty of Science and Information Technology

Focus area

Chemistry

Contact Details

Emailmichael.bowyer@newcastle.edu.au
Phone(02) 4921 2005 (Callaghan) (02) 4348 4119 (Ourimbah)
Fax(02) 4921 7949 (02) 4348 4145

Office

RoomV201b (Callaghan) SO1.48 (Ourimbah)
BuildingScience Offices
LocationOurimbah
10 Chittaway Road
Ourimbah, NSW 2258
Australia
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