Dr Ian Van Altena

Dr Ian Van Altena

Lecturer

School of Environmental and Life Sciences (Chemistry)

Career Summary

Biography

Undergraduate: James Cook University, Australia. BSc Chemistry, from 1972. BSc (Hons) with Prof. John Coll 1975

(Post)Graduate: The University of Alberta, Canada. PhD (Chemistry), from 1976, with Prof. William Ayer: Secondary metabolites from fungi

Post-doctoral fellow: The University of British Columbia, Canada, from 1982, with Prof. Raymond Andersen: Siderophores from dinoflagellates

Senior Teaching Fellow: University of Adelaide, Australia, from 1985: Laboratory coordinator. Research: Marine Natural Products Chemistry and chemical ecology

Assistant Lecturer: University of Adelaide, Australia, 1991: Laboratory coordinator, lecturer. Research: Marine Natural Products Chemistry and chemical ecology

Lecturer: The University of Newcastle, Australia, from 1992. Research: Natural Products Chemistry and chemical ecology


Qualifications

  • PhD (Chemistry), University of Alberta - Canada
  • Bachelor of Science (Honours), James Cook University
  • Bachelor of Science, James Cook University

Keywords

  • chemical ecology
  • compound identification by spectrometry
  • environmental chemistry
  • general chemistry
  • medicinal chemistry
  • natural products chemistry
  • organic chemistry

Fields of Research

Code Description Percentage
030401 Biologically Active Molecules 10
030502 Natural Products Chemistry 80
060205 Marine and Estuarine Ecology (incl. Marine Ichthyology) 10

Professional Experience

UON Appointment

Title Organisation / Department
Lecturer University of Newcastle
School of Environmental and Life Sciences
Australia

Academic appointment

Dates Title Organisation / Department
1/01/1991 - 1/01/1992 Assistant Lecturer The University of Adelaide
Department of Organic Chemistry
Australia
1/01/1985 - 1/01/1991 Senior Teaching Fellow The University of Adelaide
Department of Organic Chemistry
Australia
1/06/1982 - 1/06/1984 Post-Doctoral Fellow University of British Columbia
Department of Oceanography
Canada

Membership

Dates Title Organisation / Department
Treasurer - Natural Products Group, RACI Natural Products Group, RACI
Australia
Member - American Chemical Society American Chemical Society
United States
Member - Royal Society of Chemistry Royal Society of Chemistry
Australia
Member - Royal Australian Chemical Society Royal Australian Chemical Society
Australia

Teaching

Code Course Role Duration
CHEM1010 Introductory Chemistry I
Faculty of Science and Information Technology, The University of Newcastle | Australia
lecturer, coordinator 2/03/2002 - 13/11/2016
chem1020 Introductory Chemistry II
Faculty of Science and Information Technology, The University of Newcastle | Australia
coordinator 3/02/2002 - 13/12/2016
CHEM2310 Organic Chemistry II
Faculty of Science and Information Technology, The University of Newcastle | Australia
lecturer, tutor 3/03/2002 - 13/12/2016
CHEM3310 Advanced Organic Synthesis
Faculty of Science and Information Technology, The University of Newcastle | Australia
lecturer, demonstrator 2/03/2002 - 13/12/2016
CHEM2610 Environmental Chemistry II
Faculty of Science and Information Technology,The University of Newcastle
lecturer, demonstrator 2/03/2002 - 13/12/2016
CHEM3550 Medicinal and Biological Chemistry
Faculty of Science and Information Technology,The University of Newcastle
lecturer, demonstrator 25/07/2016 - 13/12/2016
CHEM3570 Spectroscopic Characterisation of Compounds
Faculty of Science and Information Technology,The University of Newcastle
Lecturer, tutor 2/03/2002 - 13/12/2015
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (19 outputs)

Year Citation Altmetrics Link
2016 Dang TT, Vuong QV, Schreider MJ, Bowyer MC, Altena IAV, Scarlett CJ, 'The Effects of Drying on Physico-Chemical Properties and Antioxidant Capacity of the Brown Alga (Hormosira banksii (Turner) Decaisne)', Journal of Food Processing and Preservation, (2016)

© 2016 Wiley Periodicals, Inc.Hormosira banksii is a rich source of polyphenols, which can be utilized in the food or pharmaceutical industries. This study aimed to determine the... [more]

© 2016 Wiley Periodicals, Inc.Hormosira banksii is a rich source of polyphenols, which can be utilized in the food or pharmaceutical industries. This study aimed to determine the impact of six drying methods on properties of the alga H. banksii. Our data revealed that drying conditions significantly affected recovery yield, residual moisture, extraction yield, total phenolic content (TPC) as well as antioxidant capacity of H. banksii (P<0.05). Optimal conditions for oven, vacuum and de-humidification were 40, 50 and 50C, respectively, and microwave power is 840 W. Under optimal conditions, H. banksii prepared by freeze, de-humidification and vacuum had significantly higher levels of TPC, total flavonoid content (TFC) and proanthocyanidins as well as possessing stronger antioxidant capacity in comparison with those prepared by sun, microwave and oven drying methods. As freeze drying is costly and time-consuming, de-humidification (50C, air in and out of 11.1 and 15.4%) and vacuum (50C, 10 psi) were recommended for drying H. banksii Practical Applications: Algae possess various antioxidants with potential benefits for health. Drying is considered as a method for preserving materials, transport with low costs and especially first step for extraction, isolation and purification of active compounds. Thus, it is important to investigate the effects of drying conditions on the properties of the dried alga H. banksii. From the findings, the different drying conditions significantly affected the phytochemical profile and antioxidant activity of the dried alga and the optimal drying conditions could be applied for preparation of dried H. banksii for further processing (extraction, fractionation and isolation of bioactive compounds) as well as potential industrial applications (as a reference for drying H. banksii and other algae).

DOI 10.1111/jfpp.13025
Co-authors Maria Schreider, Michael Bowyer, Vanquan Vuong, C Scarlett
2016 Nguyen VT, Pham NMQ, Vuong QV, Bowyer MC, van Altena IA, Scarlett CJ, 'Phytochemical retention and antioxidant capacity of xao tam phan (Paramignya trimera) root as prepared by different drying methods', Drying Technology, 34 324-334 (2016) [C1]

© 2016, Taylor & Francis Group, LLC.Xao tam phan (Paramignya trimera (Oliv.) Guillaum) has been used as an herbal medicine for the treatment of cancer or cancer-like diseases in ... [more]

© 2016, Taylor & Francis Group, LLC.Xao tam phan (Paramignya trimera (Oliv.) Guillaum) has been used as an herbal medicine for the treatment of cancer or cancer-like diseases in recent years, particularly in Vietnam. Drying is an important step for preparation of dried materials for storage and further investigation; however, the effects of drying must be taken into account when processing samples, because this can have profound effects on the stability of phytochemical compounds and the biological activity of the dried P. trimera root. As such, this study assessed the effects of four different drying methods (conventional, hot air, vacuum, and microwave) on phytochemical retention and antioxidant capacity of P. trimera root, to identify an optimal drying method for P. trimera root. The results showed that the drying methods significantly affected phytochemical levels and antioxidant capacity of P. trimera root and that among the four drying methods tested, microwave drying (400¿W) had the highest levels of phytochemical compounds, with total phenolic, total flavonoid, proanthocyanidin, and saponin contents of 11.27¿mg GAE, 19.88¿mg RE, 3.98¿mg CE, and 267.15¿mg EE/gram of dried sample, respectively. Dried sample prepared using this method had antioxidant capacity comparable to that of other drying methods. In addition, this method had the shortest drying time (0.28¿h) and consumed the least energy (0.28¿kWh). Therefore, microwave drying should be considered for drying P. trimera root for further investigation and utilization.

DOI 10.1080/07373937.2015.1053566
Citations Scopus - 1Web of Science - 2
Co-authors C Scarlett, Michael Bowyer, Vanquan Vuong
2016 Bhuyan DJ, Vuong QV, Chalmers AC, Van Altena IA, Bowyer MC, Scarlett CJ, 'Investigation of phytochemicals and antioxidant capacity of selected Eucalyptus species using conventional extraction', Chemical Papers, 70 567-575 (2016)

© 2015 Institute of Chemistry, Slovak Academy of Sciences.Eucalyptus species have found their place in traditional medicine and pharmacological research and they have also been s... [more]

© 2015 Institute of Chemistry, Slovak Academy of Sciences.Eucalyptus species have found their place in traditional medicine and pharmacological research and they have also been shown to possess a large number of phenolic compounds and antioxidants. The present study sought to implement conventional extraction to yield maximal total phenolic content (TPC), total flavonoid content (TFC), proanthocyanidins, antioxidants, and saponins from E. robusta using different solvents. The most suitable extraction solvent was further employed for extracting phytochemicals from E. saligna, E. microcorys, and E. globulus to select the Eucalyptus species with the greatest bioactive compound content. The results emphasised the efficiency of water in extracting TPC ((150.60 ± 2.47) mg of gallic acid equivalents per g), TFC ((38.83 ± 0.23) mg of rutin equivalents per g), proanthocyanidins ((5.14 ± 0.77) mg of catechin equivalents per g), and antioxidants ABTS ((525.67 ± 1.99) mg of trolox equivalents (TE) per g), DPPH ((378.61 ± 4.72) mg of TE per g); CUPRAC ((607.43 ± 6.69) mg of TE per g) from E. robusta. Moreover, the aqueous extract of E. robusta had the highest TPC, TFC and antioxidant values among the other Eucalyptus species tested. These findings highlighted the efficiency of conventional extraction in extracting natural bioactive compounds from Eucalyptus species for pharmaceutical and nutraceutical applications.

DOI 10.1515/chempap-2015-0237
Co-authors Michael Bowyer, Anita Chalmers, Vanquan Vuong, C Scarlett
2016 Nguyen VT, Bowyer MC, Van Altena IA, Scarlett CJ, 'Optimisation of microwave-assisted extraction from Phyllanthus amarus for phenolic compounds-enriched extracts and antioxidant capacity', CHEMICAL PAPERS, 70 713-725 (2016) [C1]
DOI 10.1515/chempap-2016-0009
Co-authors Michael Bowyer, C Scarlett
2016 Nguyen VT, Pham HNT, Bowyer MC, Van Altena IA, Scarlett CJ, 'Influence of solvents and novel extraction methods on bioactive compounds and antioxidant capacity of Phyllanthus amarus', Chemical Papers, 70 556-566 (2016)

© 2015 Institute of Chemistry, Slovak Academy of Sciences.Phyllanthus amarus (P. amarus) is a herbal plant used in the treatment of various diseases such as hepatitis, diabetes, ... [more]

© 2015 Institute of Chemistry, Slovak Academy of Sciences.Phyllanthus amarus (P. amarus) is a herbal plant used in the treatment of various diseases such as hepatitis, diabetes, and cancer. Efficiency of its bioactive compounds extraction and therefore the biological activity of the extracts are significantly influenced by both solvent character and extraction method. This study is aimed at the determination of the influence of six various solvents (water, acetonitrile, ethanol, methanol, ethyl acetate, and dichloromethane) and nine different extraction methods (conventional, ultrasound-assisted, microwave-assisted, and six novel methods) on the extraction efficiency and antioxidant capacity of P. amarus. The results indicated that water extracted the maximal amount of phenolics from P. amarus and had the highest antioxidant capacity, while microwave-assisted extraction provided the highest yields of phenolics and saponins, and the highest antioxidant capacity with the lowest energy consumption when compared to the other extraction methods. These findings implied that water and microwave-assisted extraction are recommended as the most effective solvent and method for the extraction of bioactive compounds from P. amarus for potential application in the pharmaceutical and nutraceutical industries.

DOI 10.1515/chempap-2015-0240
Co-authors Michael Bowyer, C Scarlett
2015 Nguyen VT, Bowyer MC, Vuong QV, Altena IAV, Scarlett CJ, 'Phytochemicals and antioxidant capacity of Xao tam phan (Paramignya trimera) root as affected by various solvents and extraction methods', Industrial Crops and Products, 67 192-200 (2015) [C1]

© 2015 Elsevier B.V.Xao tam phan (. Paramignya trimera (Oliv.) Guillaum) is a Vietnamese traditionally medicinal plant used in the treatment of numerous cancers. The preparation ... [more]

© 2015 Elsevier B.V.Xao tam phan (. Paramignya trimera (Oliv.) Guillaum) is a Vietnamese traditionally medicinal plant used in the treatment of numerous cancers. The preparation of Xao tam phan extracts including solvent type and extraction method have significant effects on extraction efficiency, phytochemical profile and biological activity. This study aimed to investigate the effects of five various solvents (water, acetonitrile, methanol, ethyl acetate and hexane) and three different extraction methods (conventional, ultrasound-assisted and microwave-assisted) on phytochemical yield and antioxidant capacity of P. trimera root from Vietnam. The results indicate that methanol extracted the maximal yield of phytochemicals from P. trimera and exhibited the greatest antioxidant capacity, with eleven compounds were identified and quantified. Microwave-assisted extraction produced the maximal phytochemical yields (except for total flavonoids) and antioxidant capacity, when compared to conventional and ultrasound-assisted extractions. These data reveal that the use of methanol and microwave-assisted extraction are recommended for extraction of biologically active phytochemicals from P. trimera root for application in the nutraceutical and/or pharmaceutical industries.

DOI 10.1016/j.indcrop.2015.01.051
Citations Scopus - 7Web of Science - 5
Co-authors Vanquan Vuong, C Scarlett, Michael Bowyer
2015 Bhuyan DJ, Quan VV, Chalmers AC, van Altena IA, Bowyer MC, Scarlett CJ, 'Microwave-assisted extraction of Eucalyptus robusta leaf for the optimal yield of total phenolic compounds', INDUSTRIAL CROPS AND PRODUCTS, 69 290-299 (2015) [C1]
DOI 10.1016/j.indcrop.2015.02.044
Citations Scopus - 8Web of Science - 7
Co-authors Michael Bowyer, C Scarlett, Anita Chalmers, Vanquan Vuong
2015 Nguyen VT, Vuong QV, Bowyer MC, Altena IAV, Scarlett CJ, 'Effects of Different Drying Methods on Bioactive Compound Yield and Antioxidant Capacity of Phyllanthus amarus', Drying Technology, 33 1006-1017 (2015) [C1]
DOI 10.1080/07373937.2015.1013197
Citations Scopus - 6Web of Science - 6
Co-authors Michael Bowyer, Vanquan Vuong, C Scarlett
2014 Zaleta-Pinet DA, Holland IP, Muñoz-Ochoa M, Murillo-Alvarez JI, Sakoff JA, van Altena IA, McCluskey A, 'Cytotoxic compounds from Laurencia pacifica.', Org Med Chem Lett, 4 8 (2014)
DOI 10.1186/s13588-014-0008-8
Co-authors Adam Mccluskey, Jennette Sakoff
2010 Laird DW, Bennett S, Bian B, Sauer B, Wright K, Hughes V, Van Altena IA, 'Chemical investigation of seven Australasian Cystophora species: New chemistry and taxonomic insights', Biochemical Systematics and Ecology, 38 187-194 (2010) [C1]
DOI 10.1016/j.bse.2009.12.010
Citations Scopus - 6Web of Science - 5
2009 McCann N, Phan DT, Attalla M, Puxty G, Fernandes D, Conway WO, et al., 'Molecular interactions between amine and carbonate species in aqueous solution: Kinetics and thermodynamics', Energy Procedia, 1 995-1002 (2009) [C1]
DOI 10.1016/j.egypro.2009.01.132
Citations Scopus - 3Web of Science - 2
Co-authors Marcel Maeder, Geoffrey Lawrance
2009 Holland IP, McCluskey A, Sakoff JA, Gilbert J, Chau N, Robinson PJ, et al., 'Steroids from an Australian Sponge Psammoclema sp', Journal of Natural Products, 72 102-106 (2009) [C1]
DOI 10.1021/np800688f
Citations Scopus - 5Web of Science - 4
Co-authors Jennette Sakoff, Adam Mccluskey
2007 Laird DW, Poole R, Wikstrom M, Van Altena IA, 'Pycnanthuquinone C, an unusual 6,6,5-tricyclic geranyltoluquinone from the Western Australian brown alga Cystophora harveyi', Journal of Natural Products, 70 671-674 (2007) [C1]
DOI 10.1021/np060566m
Citations Web of Science - 16
2006 Laird DW, Van Altena IA, 'Tetraprenyltoluquinols from the brown alga Cystophora fibrosa', Phytochemistry, 67 944-955 (2006) [C1]
DOI 10.1016/j.phytochem.2006.03.011
Citations Web of Science - 14
2006 Koysomboon S, Van Altena IA, Kato S, Chantrapromma K, 'Antimycobacterial flavonoids from Derris indica', Phytochemistry, 67 1034-1040 (2006) [C1]
DOI 10.1016/j.phytochem.2006.03.019
2003 Van Altena IA, Van Soest R, Roberge M, Andersen RJ, 'Trisphaerolide A, a Novel Polyketide from the Dominican Sponge Erylus trisphaerus', Journal of Natural Products, 561-563 (2003) [C1]
DOI 10.1021/np0205147
1999 Van Altena IA, Butler AJ, Dunne SJ, 'A new cyclized 9,11-secosterol enol-ether from the Australian sponge Euryspongia arenaria', Journal of Natural Products, 62 1154-1157 (1999) [C1]
Citations Web of Science - 14
1998 Bian B, Van Altena IA, 'Four New Compounds from the Australian Brown Alga Cystophora brownii', Australian Journal of Chemistry, 51 1157-1165 (1998) [C1]
Citations Web of Science - 8
1996 Butler AJ, van Altena IA, Dunne SJ, 'Antifouling activity oflyso-platelet-activating factor extracted from australian spongeCrella incrustans.', Journal of chemical ecology, 22 2041-2061 (1996)
Show 16 more journal articles

Conference (2 outputs)

Year Citation Altmetrics Link
2015 Bond D, Turner A, Richmond R, Sadeqzadeh E, Vuong Q, Bhuyan D, et al., 'THE SEARCH FOR NOVEL TREATMENT AGENTS FOR PANCREATIC CANCER: TALES FROM THE LAND AND SEA', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2015) [E3]
Co-authors Vanquan Vuong, Michael Bowyer, Jennette Sakoff, Anita Chalmers, Troy Gaston, C Scarlett, Judith Weidenhofer
2014 Sadeqzadeh E, Vuong QV, Goldsmith CD, Nguyen VT, Bhuyan DJ, Trung TD, et al., 'A NATURAL PRODUCT DRUG DISCOVERY PIPELINE FOR NOVEL PANCREATIC CANCER THERAPIES: A NEW CANCER RESEARCH HUB FOR THE HUNTER REGION OF NSW', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
Co-authors Anita Chalmers, Natalie Moltschaniwskyj, Michael Bowyer, Troy Gaston, Judith Weidenhofer, Rick Thorne, C Scarlett, Vanquan Vuong
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Grants and Funding

Summary

Number of grants 3
Total funding $202,778

Click on a grant title below to expand the full details for that specific grant.


19951 grants / $4,778

Computer Screen Projection in Small Classes. Applications in 3rd Year Chemometrics, 2nd Year Analytical Chemistry and 3rd Year Organic Chemistry Classes$4,778

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Marcel Maeder, Doctor Ian Van Altena
Scheme Teaching Committee Teaching Grants
Role Investigator
Funding Start 1995
Funding Finish 1995
GNo G0175880
Type Of Funding Internal
Category INTE
UON Y

19942 grants / $198,000

94 MECH C. High field NMR facilities$190,000

Funding body: Department of Education, Training & Youth Affairs

Funding body Department of Education, Training & Youth Affairs
Project Team Doctor Ian Van Altena
Scheme Mechanism C Infrastructure
Role Lead
Funding Start 1994
Funding Finish 1994
GNo G0174400
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Identification of Novel Compounds from Marine Algae$8,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Ian Van Altena
Scheme Project Grant
Role Lead
Funding Start 1994
Funding Finish 1994
GNo G0174782
Type Of Funding Internal
Category INTE
UON Y
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Research Supervision

Number of supervisions

Completed8
Current5

Total current UON EFTSL

PhD0.55

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2014 PhD Brown Algae as a Source of Bioactive Compounds for Pancreatic Cancer Treatment
PhD (Food Science), Faculty of Science and Information Technology, The University of Newcastle
Co-Supervisor
2014 PhD Bioactive Compounds, Antioxidant and Anti-Pancreatic Cancer Capacity of Two Vietnamese Medicinal Plants: Phyllanthus Amarus and Paramignya Trimera
PhD (Food Science), Faculty of Science and Information Technology, The University of Newcastle
Co-Supervisor
2014 PhD Phytochemicals Derived From Australian Eucalypts as Anticancer Agents for Pancreatic Malignancies
PhD (Food Science), Faculty of Science and Information Technology, The University of Newcastle
Co-Supervisor
2006 PhD Natural Products as a Source for Dynamin Inhibitors
Chem Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
2005 PhD Marine Natural Products
Chem Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2015 PhD Studies in Marine Natural Products. 1. Dynamin 1 Screening of Sponges from Catherine Hill Bay. 2. Chemistry of Cystophora Xiphocarpa. 3. Investigation of "Paua Greening" of Haliotis Iris from New Zealand's Cook Strait
PhD (Chemistry), Faculty of Science and Information Technology, The University of Newcastle
Principal Supervisor
2014 PhD Drugs from Nature: 1. Dynamin I Inhibitors from Mexican Marine Algae; 2. Chemical Investigation of an Australian Aboriginal Traditional Remedy
PhD (Chemistry), Faculty of Science and Information Technology, The University of Newcastle
Principal Supervisor
2012 PhD 1. Dynamin-l Inhibitors from Sessile Marine Invertebrates; 2. Chemotaxonomy of Cystophora spp.
PhD (Chemistry), Faculty of Science and Information Technology, The University of Newcastle
Co-Supervisor
2012 PhD Marine Natural Products and Brown Macroalga Cystophora Moniliformis Chemistry
PhD (Chemistry), Faculty of Science and Information Technology, The University of Newcastle
Principal Supervisor
2012 PhD Disruption of Clathrin Mediated-Endocytosis through Small Molecule Inhibition of Dynamin and Clathrin
PhD (Chemistry), Faculty of Science and Information Technology, The University of Newcastle
Co-Supervisor
2011 Masters Novel Inhibitors of Clathrin Mediated Endocytosis
M Philosophy (Chemistry), Faculty of Science and Information Technology, The University of Newcastle
Co-Supervisor
2009 PhD Norcantharidin Analogues: PP1 and PP2A Inhibition and Potential Therapeutic Development
PhD (Chemistry), Faculty of Science and Information Technology, The University of Newcastle
Co-Supervisor
2005 PhD Chemotaxonomy of the brown algal genus Cyclophoria
PhD (Chemistry), Faculty of Science and Information Technology, The University of Newcastle
Principal Supervisor
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Dr Ian Van Altena

Position

Lecturer
School of Environmental and Life Sciences
Faculty of Science and Information Technology

Focus area

Chemistry

Contact Details

Email ian.vanaltena@newcastle.edu.au
Phone (02) 4921 5480
Fax (02) 4921 5472
Link Personal webpage

Office

Room C322
Building Chemistry
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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