Dr Zoe Yates

Lecturer

School of Biomedical Sciences and Pharmacy (Applied Sciences)

Career Summary

Biography

Zoe is a Research Fellow in Human Molecular Nutrition in the Discipline of Applied Sciences, in the School of Environmental & Life Sciences. Over the last decade I have developed a career in nutritional genetics. In 1999, I became a British Heart Foundation PhD Scholar at Leeds University, and as a graduate student studied the important interaction between folate status, single nucleotide polymorphisms (SNPs) of genes that code for B-vitamin dependent enzymes and human health. The focus of my research endeavours was the role of C677T MTHFR and vascular complications. Between 2005 and 2007 I worked at the University of Nottingham examining the biological basis of foetal programming and adult disease. The study investigated the early life programming of disease, addressing the molecular mechanisms that may link foetal nutrition to later life atherosclerosis. In particular, it considered the effect of maternal under-nutrition (particularly a low protein diet) and the effect of maternal hyperlipidaemia (induced by a high fat/high cholesterol diet) during pregnancy on the subsequent development of atherosclerosis in the offspring of apoE*Leiden mice. Currently I am appointed as a University of Newcastle Research Fellow within the School of Environmental & Life Sciences, Ourimbah campus (commenced June 2007). The purpose of this appointment is to broaden the Molecular Nutrition research portfolio to encompass a range of degenerative disorders, both related to vascular disease and cancer. More specifically I aim to develop in vitro and in vivo methodologies that examine genomic integrity and provide a simple functional measure of nutritional adequacy along with a measure of modulatory pressures exerted by common SNPs in B-vitamin related genes. Essentially, my research interests cover nutritional biochemistry, molecular biology and genetics of disease processes, in particularly how folate bioavailability, metabolism, nutritional status and genetics modulate risk of serious human conditions such as heart disease, stroke, cancer, dementia, spina bifida and other conditions affecting pregnancy outcomes. In addition, I am interested in the very topical issues associated with mandatory fortification of grain at source with synthetic folic acid. Since being in Australia I have been invited to speak at several conferences including the 3rd Asia Pacific Nutrigenomics Conference in Melbourne (2008) and the 2nd Meeting of Nutrition Society Australia (Newcastle, 2008). I have authored/co-authored over 35 peer-reviewed scientific publications including several in extremely high impact factor journals such as Nature Reviews Genetics, Lancet, and Journal of the National Cancer Institute, and also have a chapter in Folate and Development. Last year I obtained a Ramaciotti Foundation Establishment Grant to pursue my line of research, and in 2007 was successful in obtaining a University of Newcastle Strategic Pilot Grant to look at bitter taste phenotype, dietary pattern and nutritional genetics in the aetiopathology of human colonic adenoma/cancer. My professional activities include being a committee member of Nutrition Society of Australia (Newcastle) and an active member of University of Newcastle's Institutional Biosafety Committee. Research Expertise
Over the last decade I have developed a career in nutritional biochemistry, molecular biology and genetics of disease processes, in particularly how folate bioavailability, metabolism, nutritional status and genetics modulate risk of serious human conditions such as heart disease, stroke, cancer, dementia, spina bifida and other conditions affecting pregnancy outcomes. An expert in several laboratory techniques. Other research skills include; project design and management, article preparation and review, grant preparation and submission.

Teaching Expertise
To date has specialized in teaching Research Methods. Essentially providing a detailed view of the methods used in scientific research. Covering access to and critical evaluation of literature, design and conduct of experiments, handling and analysis of experimental data and the reporting and publication of results. Aspects such as generation and testing of hypotheses based on existing knowledge, generation of aims, animal and human ethics considerations and applications, health and safety issues, importance and choice of methodology including power analyses, preparation of data and statistical analyses, interpretation and publishing of results, the grant application process and the patent application process. Also teach RHD & Honour students principles of good research practice within the laboratory.

Administrative Expertise
Laboratory management Health & Safety

Collaborations
Research interests cover nutritional biochemistry, molecular biology and genetics of disease processes, in particularly how folate bioavailability, metabolism, nutritional status and genetics modulate risk of serious human conditions such as heart disease, stroke, cancer, dementia, spina bifida and other conditions affecting pregnancy outcomes. I am also very interested in the topical issues associated with mandatory fortification of grain at source with synthetic folic acid. In conjunction with the above I am interested in the biological basis of foetal programming and adult disease, particularly the molecular mechanisms that may link foetal nutrition to later life atherosclerosis.

Qualifications

  • PhD, University of Leeds - UK
  • Bachelor of Science (Honours), University of Leeds - UK

Keywords

  • Folic Acid
  • Genetic variations
  • Nutrition
  • Research Methods

Languages

  • English (Fluent)

Fields of Research

Code Description Percentage
110399 Clinical Sciences not elsewhere classified 55
111199 Nutrition and Dietetics not elsewhere classified 20
111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified 25

Professional Experience

UON Appointment

Title Organisation / Department
Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
1/06/2007 - 1/06/2012 Fellow UON

UoN Research Fellowship

University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/2005 - 1/05/2007 Postdoctoral Researcher The University of Nottingham
Department of Nutritional Sciences
United Kingdom
1/12/2003 - 1/03/2004 Research Assistant

Applied Sciences

University of Newcastle
School of Environmental and Life Sciences
Australia

Membership

Dates Title Organisation / Department
Member - Nutrition Society of Australia (Newcastle) Nutrition Society of Australia
Australia

Professional appointment

Dates Title Organisation / Department
1/03/2003 - 1/11/2003 Research Scientist University of Leeds
Unit of Peadiatrics, Obstetrics & Gynaecology
United Kingdom

Invitations

Participant

Year Title / Rationale
2008 3rd Asia Pacific Nutrigenomics Conference
Organisation: Nutrigenomics & Nutrigenetics Description: An invited speaker and chair of a session. 30 minute presentation entitled "Folate and the C677T MTHFR variant - Impact on population health.

Speaker

Year Title / Rationale
2010 Nutrition Society Australia (Sydney AGM)
Organisation: Sydney Group Description: 45 minute seminar entitled "Folate - Nutrient - gene interactions. What does the future hold?
2008 2nd Meeting of Nutrition Society Australia
Organisation: Newcastle Group Description: Presented at the local Nutrition Society Australia meeting on Minor Nutrients - Major Impact. Expenses were paid.
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (54 outputs)

Year Citation Altmetrics Link
2015 Lucock M, Yates Z, Martin C, Choi J-H, Beckett E, Boyd L, et al., 'Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence', BBA Clinical, 3 107-112 (2015)

Purpose: The aim of this study is to explore whether a methylation diet influences risk for adenomatous polyps (AP) either independently, or interactively with one-carbon metaboli... [more]

Purpose: The aim of this study is to explore whether a methylation diet influences risk for adenomatous polyps (AP) either independently, or interactively with one-carbon metabolism-dependent gene variants, and whether such a diet modifies blood homocysteine, a biochemical phenotype closely related to the phenomenon of methylation. Methods: 249 subjects were examined using selective fluorescence, PCR and food frequency questionnaire to determine homocysteine, nine methylation-related gene polymorphisms, dietary methionine, 5-methyltetrahydrofolate, vitamins B6 and B12. Results: 1). Both dietary methionine and 5-methyltetrahydrofolate intake are significantly associated with plasma homocysteine. 2). Dietary methionine is related to AP risk in 2R3R-TS wildtype subjects, while dietary B12 is similarly related to this phenotype in individuals heterozygous for C1420T-SHMT, A2756G-MS and 844ins68-CBS, and in those recessive for 2R3R-TS. 3). Dietary methionine has a marginal influence on plasma homocysteine level in C1420T-SHMT heterozygotes, while B6 exhibits the same effect on homocysteine in C776G-TCN2 homozygote recessive subjects. Natural 5-methyltetrahydrofolate intake is interesting: Wildtype A1298C-MTHFR, heterozygote C677T-MTHFR, wildtype A2756G-MS and recessive A66G-MSR individuals all show a significant reciprocal association with homocysteine. 4). Stepwise regression of all genotypes to predict risk for AP indicated A2756G-MS and A66G-MSR to be most relevant (p= 0.0176 and 0.0408 respectively). Results were corrected for age and gender. Conclusion: A methylation diet influences methyl group synthesis in the regulation of blood homocysteine level, and is modulated by genetic interactions. Methylation-related nutrients also interact with key genes to modify risk of AP, a precursor of colorectal cancer. Independent of diet, two methylation-related genes (A2756G-MS and A66G-MSR) were directly associated with AP occurrence.

DOI 10.1016/j.bbacli.2014.11.005
Citations Scopus - 1
Co-authors Mark Lucock, Martin Veysey
2015 Choi JH, Yates Z, Martin C, Boyd L, Ng X, Skinner V, et al., 'Genetic Variation in Glutamate Carboxypeptidase II and Interaction with Dietary Natural Vitamin C May Predict Risk for Adenomatous Polyp Occurrence.', Asian Pac J Cancer Prev, 16 4383-4386 (2015)
Co-authors Martin Veysey, Mark Lucock
2015 Beckett EL, Martin C, Choi JH, King K, Niblett S, Boyd L, et al., 'Folate status, folate-related genes and serum miR-21 expression: Implications for miR-21 as a biomarker', BBA Clinical, 4 45-51 (2015)

Background: Free circulating microRNA (miRNA) in serum may be valuable biomarkers for disease diagnosis and prognosis. miR-21, the archetypal oncogenic miRNA, has been proposed as... [more]

Background: Free circulating microRNA (miRNA) in serum may be valuable biomarkers for disease diagnosis and prognosis. miR-21, the archetypal oncogenic miRNA, has been proposed as a biomarker for colorectal cancer and its benign precursor, adenomatous polyps. However, it is now becoming clear that circulating miRNA profiles may be sensitive to lifestyle and environmental influences. Dietary components involved in one-carbon metabolism are particularly well placed to modulate miRNA expression through an influence on DNA methylation pathways. Methods: We investigated the role of methyl group donors (folate, B12, cysteine, homocysteine), polymorphisms of the enzymes of one-carbon metabolism, and serum miR-21 expression in a primary case-control cohort (colonoscopy confirmed adenomatous colon polyps vs controls; n. =. 253) and a secondary cross-sectional cohort (over 65s; n. =. 649). The relationships between these parameters and serum miR-21 levels were assessed, stratified by gender. Conclusions: Serum miR-21 expression was related to occurrence of adenomatous polyps in females, but not males. Folate levels and MTHFR-C677T genotype was associated with miR-21 expression in both genders. Additionally, DHFR-19 del and MSR-A66G were associated with miR-21 expression in females and males, respectively. Stimulation with excess folate increased expression of miR-21 in colon cancer cell lines. General significance: This study demonstrates that serum miR-21 expression correlates with folate status and related genetic status. This may have consequences for the proposed use of miR-21 as a colorectal cancer biomarker.

DOI 10.1016/j.bbacli.2015.06.006
Co-authors Martin Veysey, Mark Lucock
2015 Lucock M, Jones P, Martin C, Beckett E, Yates Z, Furst J, Veysey M, 'Vitamin D: Beyond Metabolism.', J Evid Based Complementary Altern Med, 20 310-322 (2015)
DOI 10.1177/2156587215580491
Co-authors John Furst, Martin Veysey, Mark Lucock
2014 Beckett EL, Yates Z, Veysey M, Duesing K, Lucock M, 'The role of vitamins and minerals in modulating the expression of microRNA.', Nutr Res Rev, 27 94-106 (2014) [C1]
DOI 10.1017/S0954422414000043
Co-authors Martin Veysey, Mark Lucock
2014 Beckett EL, Martin C, Duesing K, Jones P, Furst J, Yates Z, et al., 'Vitamin D Receptor Genotype Modulates the Correlation between Vitamin D and Circulating Levels of let-7a/b and Vitamin D Intake in an Elderly Cohort.', J Nutrigenet Nutrigenomics, 7 264-273 (2014)
DOI 10.1159/000381676
Co-authors John Furst, Martin Veysey, Mark Lucock
2014 Beckett EL, Yates Z, Veysey M, Duesing K, Lucock M, 'The role of vitamins and minerals in modulating the expression of microRNA', Nutrition Research Reviews, 27 94-106 (2014) [C1]

A growing number of studies in recent years have highlighted the importance of molecular nutrition as a potential determinant of health and disease. In particular, the ability of ... [more]

A growing number of studies in recent years have highlighted the importance of molecular nutrition as a potential determinant of health and disease. In particular, the ability of micronutrients to regulate the final expression of gene products via modulation of transcription and translation is now being recognised. Modulation of microRNA (miRNA) by nutrients is one pathway by which nutrition may mediate gene expression. MiRNA, a class of non-coding RNA, can directly regulate gene expression post-transcriptionally. In addition, miRNA are able to indirectly influence gene expression potential at the transcriptional level via modulation of the function of components of the epigenetic machinery (DNA methylation and histone modifications). These mechanisms interact to form a complex, bi-directional regulatory circuit modulating gene expression. Disease-specific miRNA profiles have been identified in multiple disease states, including those with known dietary risk factors. Therefore, the role that nutritional components, in particular, vitamins and minerals, play in the modulation of miRNA profiles, and consequently health and disease, is increasingly being investigated, and as such is a timely subject for review. The recently posited potential for viable exogenous miRNA to enter human blood circulation from food sources adds another interesting dimension to the potential for dietary miRNA to contribute to gene modulation. © 2014 The Authors.

DOI 10.1017/S0954422414000043
Citations Scopus - 2Web of Science - 1
Co-authors Mark Lucock, Martin Veysey
2014 Beckett EL, Yates Z, Veysey M, Duesing K, Lucock M, 'The role of vitamins and minerals in modulating the expression of microRNA', Nutrition Research Reviews, 27 94-106 (2014)
DOI 10.1017/S0954422414000043
Co-authors Mark Lucock, Martin Veysey
2014 Beckett EL, Yates Z, Veysey M, Duesing K, Lucock M, 'The role of vitamins and minerals in modulating the expression of microRNA', Nutrition Research Reviews, 96 (2014)

A growing number of studies in recent years have highlighted the importance of molecular nutrition as a potential determinant of health and disease. In particular, the ability of ... [more]

A growing number of studies in recent years have highlighted the importance of molecular nutrition as a potential determinant of health and disease. In particular, the ability of micronutrients to regulate the final expression of gene products via modulation of transcription and translation is now being recognised. Modulation of microRNA (miRNA) by nutrients is one pathway by which nutrition may mediate gene expression. miRNA, a class of non-coding RNA, can directly regulate gene expression post-transcriptionally. In addition, miRNA are able to indirectly influence gene expression potential at the transcriptional level via modulation of the function of components of the epigenetic machinery (DNA methylation and histone modifications). These mechanisms interact to form a complex, bi-directional regulatory circuit modulating gene expression. Disease-specific miRNA profiles have been identified in multiple disease states, including those with known dietary risk factors. Therefore, the role that nutritional components, in particular, vitamins and minerals, play in the modulation of miRNA profiles, and consequently health and disease, is increasingly being investigated, and as such is a timely subject for review. The recently posited potential for viable exogenous miRNA to enter human blood circulation from food sources adds another interesting dimension to the potential for dietary miRNA to contribute to gene modulation.

DOI 10.1017/S0954422414000043
Citations Scopus - 1
Co-authors Mark Lucock, Martin Veysey
2014 Beckett EL, Martin C, Duesing K, Jones P, Furst J, Yates Z, et al., 'Vitamin D receptor genotype modulates the correlation between vitamin D and circulating levels of let-7a/b and vitamin D intake in an elderly cohort', Journal of Nutrigenetics and Nutrigenomics, 7 264-273 (2014)

Background and Aims: Circulating microRNAs (miRNAs) are linked to disease and are potential biomarkers. Vitamin D may modulate miRNA profiles, and vitamin D status has been linked... [more]

Background and Aims: Circulating microRNAs (miRNAs) are linked to disease and are potential biomarkers. Vitamin D may modulate miRNA profiles, and vitamin D status has been linked to risk of disease, including cardiovascular disease and cancers. We hypothesise that genotypic variance influences these relationships. We examined the correlations between vitamin D intake and circulating levels of the miRNAs let-7a/b, and the involvement of two common vitamin D receptor (VDR) polymorphisms, BsmI and ApaI. Methods: Two hundred participants completed food frequency and supplement questionnaires, and were assayed for circulating let-7b expression by qPCR. Polymorphisms were detected using restriction fragment length polymorphism-PCR. Results: let-7b expression negatively correlated with vitamin D intake (rs = -0.20, p = 0.005). The magnitude and direction of correlation were maintained in the presence of the BsmI restriction site (rs = -0.27, p = 0.0005). However, in the absence of BsmI restriction site, the direction of the correlation was reversed (rs = +0.319, p = 0.0497). These correlations were significantly different (z-score = 2.64, p = 0.0085). The correlation between vitamin D intake and let-7a was only significant in those without the ApaI restriction site. Conclusions: The correlation between vitamin D intake and let-7a/b expression in this cohort varies with VDR genotype. This study highlights the importance of considering underlying genotypic variance in miRNA expression studies and in nutritional epigenetics generally.

DOI 10.1159/000381676
Citations Scopus - 2
Co-authors Mark Lucock, John Furst, Martin Veysey
2014 Beckett EL, Martin C, Yates Z, Veysey M, Duesing K, Lucock M, 'Bitter taste genetics-the relationship to tasting, liking, consumption and health', Food and Function, 5 3040-3054 (2014) [C1]

Bitter is the most complex of human tastes, and is arguably the most important. Aversion to bitter taste is important for detecting toxic compounds in food; however, many benefici... [more]

Bitter is the most complex of human tastes, and is arguably the most important. Aversion to bitter taste is important for detecting toxic compounds in food; however, many beneficial nutrients also taste bitter and these may therefore also be avoided as a consequence of bitter taste. While many polymorphisms in TAS2R genes may result in phenotypic differences that influence the range and sensitivity of bitter compounds detected, the full extent to which individuals differ in their abilities to detect bitter compounds remains unknown. Simple logic suggests that taste phenotypes influence food preferences, intake and consequently health status. However, it is becoming clear that genetics only plays a partial role in predicting preference, intake and health outcomes, and the complex, pleiotropic relationships involved are yet to be fully elucidated. This journal is

DOI 10.1039/c4fo00539b
Co-authors Mark Lucock, Martin Veysey
2014 Lucock MD, Martin CE, Yates ZR, Veysey M, 'Diet and Our Genetic Legacy in the Recent Anthropocene: A Darwinian Perspective to Nutritional Health', Journal of Evidence-Based Complementary and Alternative Medicine, 19 68-83 (2014) [C1]

Nutrient-gene research tends to focus on human disease, although such interactions are often a by-product of our evolutionary heritage. This review explores health in this context... [more]

Nutrient-gene research tends to focus on human disease, although such interactions are often a by-product of our evolutionary heritage. This review explores health in this context, reframing genetic variation/epigenetic phenomena linked to diet in the framework of our recent evolutionary past. This "Darwinian/evolutionary medicine" approach examines how diet helped us evolve among primates and to adapt (or fail to adapt) our metabolome to specific environmental conditions leading to major diseases of civilization. This review presents updated evidence from a diet-gene perspective, portraying discord that exists with respect to health and our overall nutritional, cultural, and activity patterns. While Darwinian theory goes beyond nutritional considerations, a significant component within this concept does relate to nutrition and the mismatch between genes, modern diet, obesogenic lifestyle, and health outcomes. The review argues that nutritional sciences should expand knowledge on the evolutionary connection between food and disease, assimilating it into clinical training with greater prominence. © The Author(s) 2013.

DOI 10.1177/2156587213503345
Citations Scopus - 3
Co-authors Mark Lucock, Martin Veysey
2014 Choi J-H, Yates Z, Veysey M, Heo Y-R, Lucock M, 'Contemporary issues surrounding folic acid fortification initiatives', Preventive Nutrition and Food Science, 19 247-260 (2014) [C1]

The impact of folate on health and disease, particularly pregnancy complications and congenital malformations, has been extensively studied. Mandatory folic acid fortification the... [more]

The impact of folate on health and disease, particularly pregnancy complications and congenital malformations, has been extensively studied. Mandatory folic acid fortification therefore has been implemented in multiple countries, resulting in a reduction in the occurrence of neural tube defects. However, emerging evidence suggests increased folate intake may also be associated with unexpected adverse effects. This literature review focuses on contemporary issues of concern, and possible underlying mechanisms as well as giving consideration the future direction of mandatory folic acid fortification. Folate fortification has been associated with the presence of unmetabolized folic acid (PteGlu) in blood, masking of vitamin B12 deficiency, increased dosage for anti-cancer medication, photo-catalysis of PteGlu leading to potential genotoxicity, and a role in the pathoaetiology of colorectal cancer. Increased folate intake has also been associated with twin birth and insulin resistance in offspring, and altered epigenetic mechanisms of inheritance. Although limited data exists to elucidate potential mechanisms underlying these issues, elevated blood folate level due to the excess use of PteGlu without consideration of an individual's specific phenotypic traits (e.g. genetic background and undiagnosed disease) may be relevant. Additionally, the accumulation of unmetabolized PteGlu may lead to inhibition of dihydrofolate reductase and other enzymes. Concerns notwithstanding, folic acid fortification has achieved enormous advances in public health. It therefore seems prudent to target and carefully monitor high risk groups, and to conduct well focused further research to better understand and to minimize any risk of mandatory folic acid fortification.

DOI 10.3746/pnf.2014.19.4.247
Citations Scopus - 1
Co-authors Martin Veysey, Mark Lucock
2014 Lucock M, Yates Z, Martin C, Choi JH, Boyd L, Tang S, et al., 'Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes.', Evolution, Medicine, and Public Health, 2014 69-91 (2014) [C1]
DOI 10.1093/emph/eou013
Co-authors Martin Veysey, Paul Roach, Mark Lucock, John Furst
2014 Beckett EL, Martin C, Yates Z, Veysey M, Duesing K, Lucock M, 'Bitter taste genetics--the relationship to tasting, liking, consumption and health.', Food Funct, 5 3040-3054 (2014) [C1]
DOI 10.1039/c4fo00539b
Co-authors Martin Veysey, Mark Lucock
2014 Martin CE, Veysey M, Yates Z, Lucock MD, 'Vitamin D: Genetics, Environment & Health', Food and Nutritional Disorders, 3 1-19 (2014) [C1]
DOI 10.4172/2324-9323.1000155
Co-authors Martin Veysey, Mark Lucock
2013 Lucock MD, Martin C, Boyd L, Naumovski N, Roach P, Yates Z, Veysey M, 'Response to 'calcium, phosphate and the risk of cardiovascular events and all-cause mortality in a population with stable coronary heart disease'', HEART, 99 349-350 (2013) [C3]
DOI 10.1136/heartjnl-2012-302480
Co-authors Mark Lucock, Paul Roach, Martin Veysey
2013 Lucock M, Yates Z, Boyd L, Naylor C, Choi J, Ng X, et al., 'Vitamin C-related nutrient-nutrient and nutrient-gene interactions that modify folate status', European Journal of Nutrition, 52 569-582 (2013) [C1]
DOI 10.1007/s00394-012-0359-8
Citations Scopus - 8Web of Science - 4
Co-authors Martin Veysey, Paul Roach, Mark Lucock
2013 Lucock M, Yates Z, Martin C, Choi J, Boyd L, Tang S, et al., 'Hydrogen sulphide-related thiol metabolism and nutrigenetics in relation to hypertension in an elderly population', Genes & Nutrition, 8 221-229 (2013) [C1]
DOI 10.1007/s12263-012-0317-3
Citations Scopus - 3Web of Science - 1
Co-authors Martin Veysey, Paul Roach, Mark Lucock
2012 Lucock MD, Glanville T, Yates ZR, Walker J, Furst JE, Simpson N, 'Solar cycle predicts folate-sensitive neonatal genotypes at discrete phases of the first trimester of pregnancy: A novel folate-related human embryo loss hypothesis', Medical Hypotheses, 79 210-215 (2012) [C1]
Citations Scopus - 5Web of Science - 4
Co-authors Mark Lucock, John Furst
2011 Lucock MD, Ng X, Boyd L, Skinner VM, Wai R, Tang S, et al., 'TAS2R38 bitter taste genetics, dietary vitamin C, and both natural and synthetic dietary folic acid predict folate status, a key micronutrient in the pathoaetiology of adenomatous polyps', Food & Function, 2 457-465 (2011) [C1]
DOI 10.1039/c1fo10054h
Citations Scopus - 7Web of Science - 5
Co-authors Martin Veysey, Paul Roach, Mark Lucock
2010 Lucock MD, Glanville T, Ovadia L, Yates ZR, Walker J, Simpson N, 'Photoperiod at conception predicts C677T-MTHFR genotype: A novel gene-environment interaction', American Journal of Human Biology, 22 484-489 (2010) [C1]
DOI 10.1002/ajhb.21022
Citations Scopus - 11Web of Science - 7
Co-authors Mark Lucock
2010 Naumovski N, Veysey M, Ng X, Boyd L, Dufficy L, Blades BL, et al., 'The folic acid endophenotype and depression in an elderly population', Journal of Nutrition, Health and Aging, 14 829-833 (2010) [C1]
DOI 10.1007/s12603-010-0135-5
Citations Scopus - 3Web of Science - 2
Co-authors Maureen Townley-Jones, Mark Lucock, Paul Roach, Martin Veysey
2009 Ng X, Boyd L, Dufficy L, Naumovski N, Blades BL, Travers C, et al., 'Folate nutritional genetics and risk for hypertension in an elderly population sample', Journal of Nutrigenetics and Nutrigenomics, 2 1-8 (2009) [C1]
DOI 10.1159/000160079
Citations Scopus - 12Web of Science - 9
Co-authors Mark Lucock, Martin Veysey, Maureen Townley-Jones, Paul Roach
2009 Yates Z, Tarling E, Langely-Evans S, Salter A, 'Maternal undernutrition programmes atherosclerosis in the APOE3 Leiden mouse', The British Journal of Nutrition: an international journal of nutritional science, 101 1185-1195 (2009) [C1]
DOI 10.1017/S0007114508066786
Citations Scopus - 23Web of Science - 19
2009 Sohn K-J, Jang H, Campan M, Weisenberger DJ, Dickhout J, Wang Y-C, et al., 'The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: A possible molecular basis for the site-specific cancer risk modification', International Journal of Cancer, 124 1999-2005 (2009) [C1]
DOI 10.1002/ijc.24003
Citations Scopus - 43Web of Science - 43
Co-authors Mark Lucock
2009 Lucock MD, Yates ZR, 'Folic acid fortification: A double-edged sword', Current Opinion in Clinical Nutrition & Metabolic Care, 12 555-564 (2009) [C1]
DOI 10.1097/mco.0b013e32833192bc
Citations Scopus - 42Web of Science - 33
Co-authors Mark Lucock
2008 Palep-Singh M, Picton HM, Yates ZR, Barth J, Balen AH, 'Plasma homocysteine concentrations and the single nucleotide polymorphism in the methionine synthase gene (MTR 2756A>G): Associations with the polycystic ovary syndrome An observational study', European Journal of Obstetrics Gynecology and Reproductive Biology, 138 180-186 (2008) [C1]
DOI 10.1016/j.ejogrb.2007.12.015
Citations Scopus - 9Web of Science - 7
2007 Palep-Singh M, Picton H, Yates Z, Barth J, Balen A, 'Polycystic ovary syndrome and the single nucleotide polymorphisms of methylenetetrahydrofolate reductase: a pilot observational study.', Human Fertility: an international multidisciplinary journal dedicated to furthering research and promoting good practice, 10 33-41 (2007) [C1]
DOI 10.1080/14647270600950157
2007 Lucock MD, Yates ZR, Ng X, Veysey MJ, Blades BL, Travers C, et al., 'Preliminary evidence for genetic selection of 677T-MTHFR by natural annual cycle of folate abundance', Journal of Nutrigenetics and Nutrigenomics, 1 24-29 (2007) [C1]
DOI 10.1159/000109872
Citations Scopus - 10Web of Science - 8
Co-authors Martin Veysey, Mark Lucock, Paul Roach
2006 Dufficy L, Naumovski N, Ng X, Blades BL, Yates ZR, Travers C, et al., 'G80A reduced folate carrier SNP influences the absorption and cellular translocation of dietary folate and its association with blood pressure in an elderly population', Life Sciences, 79 957-966 (2006) [C1]
DOI 10.1016/j.lfs.2006.05.009
Citations Scopus - 20Web of Science - 20
Co-authors Mark Lucock, Paul Roach, Martin Veysey
2006 Glanville T, Yates ZR, Ovadia L, Walker JJ, Lucock MD, Simpson NAB, 'Fetal folate C677T methylenetetrahydrofolate reductase gene polymorphism and low birth weight', Journal of Obstetrics and Gynaecology, 26 11-14 (2006) [C1]
DOI 10.1080/01443610500363865
Citations Scopus - 10
Co-authors Mark Lucock
2006 Lucock MD, Yates ZR, 'Synergy between 677 TT MTHFR genotype and related folate SNPs regulates homocysteine level', Nutrition Research, 26 180-185 (2006) [C1]
DOI 10.1016/j.nutres.2006.01.001
Citations Scopus - 6Web of Science - 6
Co-authors Mark Lucock
2005 Lucock MD, Ng X, Veysey MJ, Yates ZR, 'Folic acid: An essential nutrient with added health benefits', Biologist, 52 21-27 (2005) [C1]
Citations Scopus - 2
Co-authors Mark Lucock, Martin Veysey
2005 Yates ZR, Lucock MD, 'G80A reduced folate carrier SNP modulates cellular uptake of folate and affords protection against thrombosis via a non homocysteine related mechanism', Life Sciences, 77 2735-2742 (2005) [C1]
DOI 10.1016/j.lfs.2005.02.029
Citations Scopus - 31Web of Science - 31
Co-authors Mark Lucock
2005 Lucock MD, Yates ZR, 'Human genetic selection by folates', Nature Reviews Genetics, 6 online (2005) [C3]
Co-authors Mark Lucock
2004 Sohn K-J, Smirnakis F, Moskovitz DN, Novakovic P, Yates ZR, Lucock MD, et al., 'Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate', GUT, 53 1825-1831 (2004) [C1]
DOI 10.1136/gut.2004.042713
Citations Scopus - 18Web of Science - 17
Co-authors Mark Lucock
2004 Sohn K-J, Croxford R, Yates ZR, Lucock MD, Kim Y-I, 'Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate', Journal of the National Cancer Institute, 96 134-144 (2004) [C1]
DOI 10.1093/jnci/djh
Citations Scopus - 160Web of Science - 149
Co-authors Mark Lucock
2003 Lucock MD, Yates ZR, Glanville T, Leeming R, Simpson N, Daskalakis I, 'A critical role for B-vitamin nutrition in human developmental and evolutionary biology', Nutrition Research, 23 1463-1475 (2003) [C1]
DOI 10.1016/S0271-5317(03)00156-8
Citations Scopus - 40Web of Science - 26
Co-authors Mark Lucock
2003 Fenton J, Pratt G, Rawstron A, Sibley K, Rothwell D, Yates Z, et al., 'Genomic characterisation of the chromosomal breakpoints of t(4; 14) of multiple myeloma suggests more than one possible aetiological mechanism', Oncogene, 22 1103-1113 (2003) [C1]
DOI 10.1038/sj.onc.1206335
2003 Yates Z, Lucock M, 'Interaction between common folate polymorphisms and B-vitamin nutritional status modulates homocysteine and risk for a thrombotic event', MOLECULAR GENETICS AND METABOLISM, 79 201-213 (2003) [C1]
DOI 10.1016/S1096-7192(03)00093-3
Citations Scopus - 16Web of Science - 15
Co-authors Mark Lucock
2002 Lucock M, Yates Z, 'Measurement of red blood cell methylfolate', LANCET, 360 1021-1022 (2002) [C1]
DOI 10.1016/S0140-6736(02)11105-6
Citations Scopus - 8Web of Science - 5
Co-authors Mark Lucock
2002 Yates Z, Lucock M, 'Methionine synthase, polymorphism A2756G is associated with susceptibility for thromboembolic events and altered B vitamin/thiol metabolism', HAEMATOLOGICA, 87 751-756 (2002) [C1]
Citations Scopus - 18Web of Science - 18
Co-authors Mark Lucock
2002 Lucock M, Yates Z, Hall K, Leeming R, Rylance G, MacDonald A, Green A, 'The impact of phenylketonuria on folate metabolism', MOLECULAR GENETICS AND METABOLISM, 76 305-312 (2002) [C1]
DOI 10.1016/S1096-7192(02)00113-0
Citations Scopus - 12Web of Science - 10
Co-authors Mark Lucock
2001 Lucock M, Daskalakis I, Yates Z, 'C677T MTHFR genotypes show graded response to vitamin B-12 dependent regeneration of tetrahydrofolate, the main congener of all cellular folates', NUTRITION RESEARCH, 21 1357-1362 (2001) [C1]
DOI 10.1016/S0271-5317(01)00345-1
Citations Scopus - 2Web of Science - 1
Co-authors Mark Lucock
2001 Lucock M, Daskalakis I, Hinkins M, Yates Z, 'An examination of polymorphic genes and folate metabolism in mothers affected by a spina bifida pregnancy', MOLECULAR GENETICS AND METABOLISM, 73 322-332 (2001) [C1]
DOI 10.1006/mgme.2001.3205
Citations Scopus - 27Web of Science - 25
Co-authors Mark Lucock
2001 Lucock M, Yates Z, 'Update on folic acid and neural tube defects: 'Comment' article', Clinical Nutrition, 10 25-33 (2001) [C1]
2000 Lucock M, Daskalakis I, Briggs D, Yates Z, Levene M, 'Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: Influence of 677c -> t methylenetetrahydrofolate reductase and 2756a -> g methionine synthase genotypes', MOLECULAR GENETICS AND METABOLISM, 70 27-44 (2000) [C1]
DOI 10.1006/mgme.2000.2994
Citations Scopus - 38Web of Science - 37
Co-authors Mark Lucock
1999 Pratt G, Fenton J, Proffitt J, Yates Z, Davies F, Rawstron A, et al., 'Molecular characterisation of chromosome 14q32 translocations in patients with multiple myeloma.', Blood 94, 2435., (1999) [C1]
1999 Fenton J, Proffitt J, Pratt G, Rawstron A, Yates Z, Davies F, et al., 'Identification of a novel translocation t(14;22)(q32;q12) in multiple myeloma.', British Journal of Cancer, (1999) [C1]
1999 Pratt G, Fenton J, Proffitt J, Yates Z, Davies F, Rawstron A, et al., 'Rawstron A., Child J., Morgan G. (1999) A novel translocation t(14;22)(q32;q12) in multiple myeloma.', British Journal of Haematology, (1999) [C1]
1999 Cunningham J, Yates Z, Hamilton J, Mason G, Muller R, Miller D, 'Non-invasive RNA-based determination of fetal Rhesus D type: a prospective study based on 96 pregnancies.', British Journal of Obstetrics and Gynaecology, 1023-1028 (1999) [C1]
1999 Proffitt J, Fenton J, Pratt G, Yates Z, Morgan G, 'Isolation and characterisation of recombination events involving immunoglobulin heavy chain switch regions in multiple myeloma using long distance vectorette PCR (LDV-PCR)', Leukemia, 1100-1107 (1999) [C1]
1998 Pratt G, Fenton J, Proffitt J, Yates Z, Davies F, Rawstron A, et al., 'Rapid characterisation of switch recombination events from patients with multiple myeloma and the characterisation of a novel translocation t(14;22)(q32;q12): Implications for the process of switch recombination and the pathogenesis of myeloma.', Blood 92, 278., (1998) [C1]
Show 51 more journal articles

Conference (18 outputs)

Year Citation Altmetrics Link
2014 Veysey M, Siow W, Niblett S, King K, Yates Z, Lucock M, 'Hepatic fibrosis in an elderly population', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Martin Veysey, Mark Lucock, Katrina King
2014 Veysey M, Siow W, Niblett S, King K, Yates Z, Lucock M, 'White cell counts and non-alcoholic fatty liver disease', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Mark Lucock, Martin Veysey
2013 Veysey M, Siow W, Choi J-H, Martin C, Tang S, Yates ZR, Lucock M, 'A Bitter Taste Gene (P49a Variant of Tas2r38) Interacts With A1298c-MTHFR to Modify Risk for Adenomas in an Australian Population', GASTROENTEROLOGY, Orlando, FL (2013) [E3]
Co-authors Martin Veysey, Mark Lucock
2013 Choi J, Siow W, Yates Z, Lucock M, Veysey M, 'Influence of synthetic folic acid concentration on Caco-2 cell growth', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013) [E3]
Co-authors Mark Lucock, Martin Veysey
2013 Siow W, Niblett S, King K, Yates Z, Hampe T, Lucock M, Veysey M, 'Prevalence of non-alcoholic fatty liver disease in an elderly Australian population', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013) [E3]
Co-authors Katrina King, Martin Veysey, Mark Lucock
2013 Siow W, Niblett S, King K, Yates Z, Martin C, Lucock M, Veysey M, 'A community-based study of dietary macro and micronutrients and the risk of colorectal cancer in an elderly Australian population', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013) [E3]
Co-authors Mark Lucock, Katrina King, Martin Veysey
2011 Choi J-H, Yates ZR, Boyd L, Veysey MJ, Lucock MD, 'Dietary folate vitamers as potential risk factors in the aetiology of adenomatous polyps', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authors Martin Veysey, Mark Lucock
2011 Yates ZR, Kho J, Choi J-H, Boyd L, Ng X, Skinner V, et al., 'C776G TCNII genotype influences the relationship between blood vitamin B12 and cellular folate', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authors Martin Veysey, Mark Lucock
2011 Naylor C, Lucock MD, Veysey MJ, Naumovski N, Boyd L, Dufficy L, et al., 'Folate nutritional genetics and degenerative disorders in the elderly with special reference to hypertension and depression', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authors Paul Roach, Martin Veysey, Mark Lucock
2010 Chang J, Lucock MD, Wai R, Boyd L, Ng X, Skinner VM, et al., 'Dietary folic acid, red cell folate and the risk of adenomatous polyps in an Australian population', Journal of Gastroenterology and Hepatology. Special Issue: Australian Gastroenterology Week 2010, Gold Coast, QLD (2010) [E3]
Co-authors Martin Veysey, Mark Lucock, Paul Roach
2009 Veysey MJ, Boyd L, Wai R, Ng X, Skinner V, Tang S, et al., 'Preliminary data to support a relationship between taste genetics, folate status, folate genes and the development of colonic adenomas: A novel nutrigenomic circuit', Gastro 2009 UEGW/WCOG: Scientific Programme & EACCME, London, UK (2009) [E3]
Co-authors Martin Veysey, Paul Roach, Mark Lucock
2009 Boyd L, Lucock MD, Wai R, Ng X, Yates ZR, Skinner V, et al., 'Folate status: A recognised determinant of colorectal neoplasia may be modified by bitter taste perception and genetics', Proceedings of the Nutrition Society of Australia, Newcastle, NSW (2009) [E3]
Co-authors Paul Roach, Martin Veysey, Mark Lucock
2008 Yates ZR, Lucock MD, 'Folate and the C677T-MTHFR variant: Impact on population health', Journal of Nutrigenetics and Nutrigenomics, Melbourne, VIC (2008) [E3]
DOI 10.1159/000128589
Co-authors Mark Lucock
2008 Ng X, Boyd L, Dufficy L, Naumovski N, Blades BL, Travers C, et al., 'Folate genes and risk for hypertension in an elderly population sample', 3rd Asia Pacific Nutrigenomics Conference: Conference Program & Information, Melbourne, VIC (2008) [E3]
Co-authors Martin Veysey, Paul Roach, Mark Lucock
2008 Wai RKH, Boyd L, Ng X, King K, Skinner V, Roach PD, et al., 'Preliminary evidence that bitter taste perception can modify folate status: A recognised risk factor for colorectal neoplasia', Journal of Gastroenterology and Hepatology, Brisbane, QLD (2008) [E3]
Co-authors Paul Roach, Martin Veysey, Mark Lucock
2008 Boyd L, Wai RKH, Ng X, King K, Skinner V, Roach PD, et al., 'A preliminary study to examine whether common folate polymorphisms are risk factors for the development of adenomatous polyps', Journal of Gastroenterology and Hepatology, Brisbane, QLD (2008) [E3]
Co-authors Paul Roach, Martin Veysey, Mark Lucock
2004 Novakovic P, Sohn KJ, Chiang EP, Dickhout J, Yates Z, Lucock M, et al., 'Effect of MTHFR C677T polymorphism on the intracellular methionine cycle and DNA methylation in colon cancer cells', FASEB JOURNAL, Washington, DC (2004)
Co-authors Mark Lucock
2004 Moskovitz DN, Sohn KJ, Smirnakis F, Novakovic P, Yates ZR, Lucock MD, et al., 'Effects of folylpolyglutamyl synthetase modulation on chemosensitivity of colon cancer cells to 5 fluorouracil and methotrexate', CDDW Abstracts, Canada (2004) [E3]
Co-authors Mark Lucock
Show 15 more conferences
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Grants and Funding

Summary

Number of grants 6
Total funding $686,150

Click on a grant title below to expand the full details for that specific grant.


20121 grants / $24,500

Phase I and II detoxification genes; the correlation of epigenetic modifications with nutritional status, lifestyle factors, health and disease$24,500

Funding body: CSIRO - Energy Technology

Funding body CSIRO - Energy Technology
Project Team Associate Professor Mark Lucock, Associate Professor Martin Veysey, Doctor Zoe Yates, Miss Emma Beckett, Dr Konsta Duesing
Scheme Postgraduate Research Scholarship
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200845
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20092 grants / $91,281

The Association between Folate Nutritional Status and Folate Gene Polymorphisms in an Elderly Australian Population$61,281

Funding body: Central Coast Local Health District

Funding body Central Coast Local Health District
Project Team Associate Professor Martin Veysey, Doctor Zoe Yates, Associate Professor Mark Lucock, Doctor Paul Roach
Scheme Research Sponsorship Scholarship
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0190658
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Development of a model to study the B-vitamin related nutritional genetics of human aging$30,000

Funding body: Ramaciotti Foundations

Funding body Ramaciotti Foundations
Project Team Doctor Zoe Yates
Scheme Establishment Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0189324
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20073 grants / $570,369

2007 Research Fellowship$550,618

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Zoe Yates
Scheme Research Fellowship
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0187072
Type Of Funding Internal
Category INTE
UON Y

2007 Research Fellowship Project grant$15,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Zoe Yates
Scheme Fellowship Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0188077
Type Of Funding Internal
Category INTE
UON Y

Bitter taste phenotype, dietary pattern and nutritional genetics in the aetiopathology of human colonic adenoma/cancer$4,751

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Zoe Yates
Scheme Pilot Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0187909
Type Of Funding Internal
Category INTE
UON Y
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Research Supervision

Number of supervisions

Completed1
Current2

Total current UON EFTSL

PhD0.45

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2012 PhD The Association of MIRNA Profiles and DNA Methylation with Micronutrient Intake & Status
Food Science & Biotechnology, Faculty of Science and Information Technology, The University of Newcastle
Co-Supervisor
2010 PhD Genotype-Phenotype Relationships Relevant to the Lifecycle with Special Reference to Vitamin Nutrition
Food Science & Biotechnology, Faculty of Science and Information Technology, The University of Newcastle
Principal Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2014 PhD In Vitro and In Vivo Approaches to the Examination of Folate-Related Nutritional Genetics in Health and Disease
Food Science & Biotechnology, Faculty of Science and Information Technology, The University of Newcastle
Principal Supervisor
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News

The Conversation

Superfoods: not so super after all?

June 16, 2013

By Emma Beckett and Zoe Yates, University of Newcastle

Superfoods is a buzzword now part of mainstream food and health language, often touted as miracle foods that cure all ills, stave off ageing and disease, or aid weight loss.

Dr Zoe Yates

Position

Lecturer
Human Molecular Nutrition
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Applied Sciences

Contact Details

Email zoe.yates@newcastle.edu.au
Phone (02) 4349 4560
Fax (02) 4348 4145

Office

Room BE 137
Building Health Precinct
Location Ourimbah
10 Chittaway Road
Ourimbah, NSW 2258
Australia
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