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Career Summary

Biography

Zoe is a Research Fellow in Human Molecular Nutrition in the Discipline of Applied Sciences, in the School of Environmental & Life Sciences.

Over the last decade I have developed a career in nutritional genetics. In 1999, I became a British Heart Foundation PhD Scholar at Leeds University, and as a graduate student studied the important interaction between folate status, single nucleotide polymorphisms (SNPs) of genes that code for B-vitamin dependent enzymes and human health. The focus of my research endeavours was the role of C677T MTHFR and vascular complications. Between 2005 and 2007 I worked at the University of Nottingham examining the biological basis of foetal programming and adult disease. The study investigated the early life programming of disease, addressing the molecular mechanisms that may link foetal nutrition to later life atherosclerosis. In particular, it considered the effect of maternal under-nutrition (particularly a low protein diet) and the effect of maternal hyperlipidaemia (induced by a high fat/high cholesterol diet) during pregnancy on the subsequent development of atherosclerosis in the offspring of apoE*Leiden mice.

Currently I am appointed as a University of Newcastle Research Fellow within the School of Environmental & Life Sciences, Ourimbah campus (commenced June 2007). The purpose of this appointment is to broaden the Molecular Nutrition research portfolio to encompass a range of degenerative disorders, both related to vascular disease and cancer. More specifically I aim to develop in vitro and in vivo methodologies that examine genomic integrity and provide a simple functional measure of nutritional adequacy along with a measure of modulatory pressures exerted by common SNPs in B-vitamin related genes. Essentially, my research interests cover nutritional biochemistry, molecular biology and genetics of disease processes, in particularly how folate bioavailability, metabolism, nutritional status and genetics modulate risk of serious human conditions such as heart disease, stroke, cancer, dementia, spina bifida and other conditions affecting pregnancy outcomes. In addition, I am interested in the very topical issues associated with mandatory fortification of grain at source with synthetic folic acid.

Since being in Australia I have been invited to speak at several conferences including the 3rd Asia Pacific Nutrigenomics Conference in Melbourne (2008) and the 2nd Meeting of Nutrition Society Australia (Newcastle, 2008). I have authored/co-authored over 35 peer-reviewed scientific publications including several in extremely high impact factor journals such as Nature Reviews Genetics, Lancet, and Journal of the National Cancer Institute, and also have a chapter in Folate and Development. Last year I obtained a Ramaciotti Foundation Establishment Grant to pursue my line of research, and in 2007 was successful in obtaining a University of Newcastle Strategic Pilot Grant to look at bitter taste phenotype, dietary pattern and nutritional genetics in the aetiopathology of human colonic adenoma/cancer.

My professional activities include being a committee member of Nutrition Society of Australia (Newcastle) and an active member of University of Newcastle's Institutional Biosafety Committee.

Qualifications

  • PhD, University of Leeds - UK, 12/09/2003
  • Bachelor of Science (Honours), University of Leeds - UK, 30/06/1996

Research

Research keywords

  • Folic Acid
  • Genetic variations
  • Nutrition

Research expertise

Over the last decade I have developed a career in nutritional biochemistry, molecular biology and genetics of disease processes, in particularly how folate bioavailability, metabolism, nutritional status and genetics modulate risk of serious human conditions such as heart disease, stroke, cancer, dementia, spina bifida and other conditions affecting pregnancy outcomes.

An expert in several laboratory techniques.

Other research skills include; project design and management, article preparation and review, grant preparation and submission.

Languages

  • English

Fields of Research

CodeDescriptionPercentage
110399Clinical Sciences Not Elsewhere Classified55
111500Pharmacology And Pharmaceutical Sciences25
111100Nutrition And Dietetics20

Memberships

Committee/Associations (relevant to research).

  • Member - Nutrition Society of Australia (Newcastle)

Invitations

Nutrition Society Australia (Sydney AGM)
Sydney Group, Australia (Invited Presenter)
2010
2nd Meeting of Nutrition Society Australia
Newcastle Group, Australia (Invited Presenter)
2008
3rd Asia Pacific Nutrigenomics Conference
Nutrigenomics & Nutrigenetics, Australia (Conference Presentation - non published.)
2008

Collaboration

Research interests cover nutritional biochemistry, molecular biology and genetics of disease processes, in particularly how folate bioavailability, metabolism, nutritional status and genetics modulate risk of serious human conditions such as heart disease, stroke, cancer, dementia, spina bifida and other conditions affecting pregnancy outcomes.

I am also very interested in the topical issues associated with mandatory fortification of grain at source with synthetic folic acid.

In conjunction with the above I am interested in the biological basis of foetal programming and adult disease, particularly the molecular mechanisms that may link foetal nutrition to later life atherosclerosis.

Administrative

Administrative expertise

Laboratory management

Health & Safety

Teaching

Teaching keywords

  • Research Methods

Teaching expertise

To date has specialized in teaching Research Methods. Essentially providing a detailed view of the methods used in scientific research. Covering access to and critical evaluation of literature, design and conduct of experiments, handling and analysis of experimental data and the reporting and publication of results. Aspects such as generation and testing of hypotheses based on existing knowledge, generation of aims, animal and human ethics considerations and applications, health and safety issues, importance and choice of methodology including power analyses, preparation of data and statistical analyses, interpretation and publishing of results, the grant application process and the patent application process.

Also teach RHD & Honour students principles of good research practice within the laboratory.

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Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (43 outputs)

YearCitationAltmetricsLink
2014Beckett EL, Yates Z, Veysey M, Duesing K, Lucock M, 'The role of vitamins and minerals in modulating the expression of microRNA.', Nutr Res Rev, 27 94-106 (2014)
2014Lucock MD, Martin CE, Yates ZR, Veysey M, 'Diet and Our Genetic Legacy in the Recent Anthropocene: A Darwinian Perspective to Nutritional Health', Journal of Evidence-Based Complementary and Alternative Medicine, 19 68-83 (2014)
2014Beckett EL, Yates Z, Veysey M, Duesing K, Lucock M, 'The role of vitamins and minerals in modulating the expression of microRNA', Nutrition Research Reviews, 27 94-106 (2014)
2014Lucock M, Yates Z, Martin C, Choi JH, Boyd L, Tang S, et al., 'Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes.', Evol Med Public Health, 2014 69-91 (2014)
2013Lucock M, Yates Z, Martin C, Choi J, Boyd L, Tang S, et al., 'Hydrogen sulphide-related thiol metabolism and nutrigenetics in relation to hypertension in an elderly population', Genes & Nutrition, 8 221-229 (2013) [C1]
2013Lucock M, Yates Z, Boyd L, Naylor C, Choi J, Ng X, et al., 'Vitamin C-related nutrient-nutrient and nutrient-gene interactions that modify folate status', European Journal of Nutrition, 52 569-582 (2013) [C1]
2013Lucock MD, Martin C, Boyd L, Naumovski N, Roach P, Yates Z, Veysey M, 'Response to 'calcium, phosphate and the risk of cardiovascular events and all-cause mortality in a population with stable coronary heart disease'', HEART, 99 349-350 (2013) [C3]
2012Lucock MD, Glanville T, Yates ZR, Walker J, Furst JE, Simpson N, 'Solar cycle predicts folate-sensitive neonatal genotypes at discrete phases of the first trimester of pregnancy: A novel folate-related human embryo loss hypothesis', Medical Hypotheses, 79 210-215 (2012) [C1]

Co-authors: John Furst, Mark Lucock

2011Lucock MD, Ng X, Boyd L, Skinner VM, Wai R, Tang S, et al., 'TAS2R38 bitter taste genetics, dietary vitamin C, and both natural and synthetic dietary folic acid predict folate status, a key micronutrient in the pathoaetiology of adenomatous polyps', Food & Function, 2 457-465 (2011) [C1]
2010Naumovski N, Veysey M, Ng X, Boyd L, Dufficy L, Blades BL, et al., 'The folic acid endophenotype and depression in an elderly population', Journal of Nutrition, Health and Aging, 14 829-833 (2010) [C1]
2010Lucock MD, Glanville T, Ovadia L, Yates ZR, Walker J, Simpson N, 'Photoperiod at conception predicts C677T-MTHFR genotype: A novel gene-environment interaction', American Journal of Human Biology, 22 484-489 (2010) [C1]
2009Lucock MD, Yates ZR, 'Folic acid fortification: A double-edged sword', Current Opinion in Clinical Nutrition & Metabolic Care, 12 555-564 (2009) [C1]
2009Sohn K-J, Jang H, Campan M, Weisenberger DJ, Dickhout J, Wang Y-C, et al., 'The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: A possible molecular basis for the site-specific cancer risk modification', International Journal of Cancer, 124 1999-2005 (2009) [C1]
2009Yates Z, Tarling E, Langely-Evans S, Salter A, 'Maternal undernutrition programmes atherosclerosis in the APOE3 Leiden mouse', The British Journal of Nutrition: an international journal of nutritional science, 101 1185-1195 (2009) [C1]
2009Ng X, Boyd L, Dufficy L, Naumovski N, Blades BL, Travers C, et al., 'Folate nutritional genetics and risk for hypertension in an elderly population sample', Journal of Nutrigenetics and Nutrigenomics, 2 1-8 (2009) [C1]
2008Palep-Singh M, Picton HM, Yates ZR, Barth J, Balen AH, 'Plasma homocysteine concentrations and the single nucleotide polymorphism in the methionine synthase gene (MTR 2756A>G): Associations with the polycystic ovary syndrome An observational study', European Journal of Obstetrics Gynecology and Reproductive Biology, 138 180-186 (2008) [C1]
2007Palep-Singh M, Picton H, Yates Z, Barth J, Balen A, 'Polycystic ovary syndrome and the single nucleotide polymorphisms of methylenetetrahydrofolate reductase: a pilot observational study.', Human Fertility: an international multidisciplinary journal dedicated to furthering research and promoting good practice, 10 33-41 (2007) [C1]
2007Lucock MD, Yates ZR, Ng X, Veysey MJ, Blades BL, Travers C, et al., 'Preliminary evidence for genetic selection of 677T-MTHFR by natural annual cycle of folate abundance', Journal of Nutrigenetics and Nutrigenomics, 1 24-29 (2007) [C1]
2006Dufficy L, Naumovski N, Ng X, Blades BL, Yates ZR, Travers C, et al., 'G80A reduced folate carrier SNP influences the absorption and cellular translocation of dietary folate and its association with blood pressure in an elderly population', Life Sciences, 79 957-966 (2006) [C1]
2006Glanville T, Yates ZR, Ovadia L, Walker JJ, Lucock MD, Simpson NAB, 'Fetal folate C677T methylenetetrahydrofolate reductase gene polymorphism and low birth weight', Journal of Obstetrics and Gynaecology, 26 11-14 (2006) [C1]
2006Lucock MD, Yates ZR, 'Synergy between 677 TT MTHFR genotype and related folate SNPs regulates homocysteine level', Nutrition Research, 26 180-185 (2006) [C1]
2005Yates ZR, Lucock MD, 'G80A reduced folate carrier SNP modulates cellular uptake of folate and affords protection against thrombosis via a non homocysteine related mechanism', Life Sciences, 77 2735-2742 (2005) [C1]
2005Lucock MD, Yates Z, 'Folic acid - vitamin and panacea or genetic time bomb?', Nature Reviews Genetics, 6 235-240 (2005) [C1]
2005Lucock MD, Ng X, Veysey MJ, Yates ZR, 'Folic acid: An essential nutrient with added health benefits', Biologist, 52 21-27 (2005) [C1]
2005Lucock MD, Yates ZR, 'Human genetic selection by folates', Nature Reviews Genetics, 6 online (2005) [C3]

Co-authors: Mark Lucock

2004Sohn K-J, Croxford R, Yates ZR, Lucock MD, Kim Y-I, 'Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate', Journal of the National Cancer Institute, 96 134-144 (2004) [C1]
2004Sohn K-J, Smirnakis F, Moskovitz DN, Novakovic P, Yates ZR, Lucock MD, et al., 'Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate', GUT, 53 1825-1831 (2004) [C1]
2003Yates Z, Lucock M, 'Interaction between common folate polymorphisms and B-vitamin nutritional status modulates homocysteine and risk for a thrombotic event', MOLECULAR GENETICS AND METABOLISM, 79 201-213 (2003) [C1]
2003Lucock MD, Yates ZR, Glanville T, Leeming R, Simpson N, Daskalakis I, 'A critical role for B-vitamin nutrition in human developmental and evolutionary biology', Nutrition Research, 23 1463-1475 (2003) [C1]
2003Fenton J, Pratt G, Rawstron A, Sibley K, Rothwell D, Yates Z, et al., 'Genomic characterisation of the chromosomal breakpoints of t(4; 14) of multiple myeloma suggests more than one possible aetiological mechanism', Oncogene, 22 1103-1113 (2003) [C1]
2002Yates Z, Lucock M, 'Methionine synthase, polymorphism A2756G is associated with susceptibility for thromboembolic events and altered B vitamin/thiol metabolism', HAEMATOLOGICA, 87 751-756 (2002) [C1]
2002Lucock M, Yates Z, 'Measurement of red blood cell methylfolate', LANCET, 360 1021-1022 (2002) [C1]
2002Lucock M, Yates Z, Hall K, Leeming R, Rylance G, MacDonald A, Green A, 'The impact of phenylketonuria on folate metabolism', MOLECULAR GENETICS AND METABOLISM, 76 305-312 (2002) [C1]
2001Lucock M, Yates Z, 'Update on folic acid and neural tube defects: 'Comment' article', Clinical Nutrition, 10 25-33 (2001) [C1]
2001Lucock M, Daskalakis I, Yates Z, 'C677T MTHFR genotypes show graded response to vitamin B-12 dependent regeneration of tetrahydrofolate, the main congener of all cellular folates', NUTRITION RESEARCH, 21 1357-1362 (2001) [C1]
2001Lucock M, Daskalakis I, Hinkins M, Yates Z, 'An examination of polymorphic genes and folate metabolism in mothers affected by a spina bifida pregnancy', MOLECULAR GENETICS AND METABOLISM, 73 322-332 (2001) [C1]
2000Lucock M, Daskalakis I, Briggs D, Yates Z, Levene M, 'Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: Influence of 677c -> t methylenetetrahydrofolate reductase and 2756a -> g methionine synthase genotypes', MOLECULAR GENETICS AND METABOLISM, 70 27-44 (2000) [C1]
1999Pratt G, Fenton J, Proffitt J, Yates Z, Davies F, Rawstron A, et al., 'Rawstron A., Child J., Morgan G. (1999) A novel translocation t(14;22)(q32;q12) in multiple myeloma.', British Journal of Haematology, (1999) [C1]
1999Pratt G, Fenton J, Proffitt J, Yates Z, Davies F, Rawstron A, et al., 'Molecular characterisation of chromosome 14q32 translocations in patients with multiple myeloma.', Blood 94, 2435., (1999) [C1]
1999Cunningham J, Yates Z, Hamilton J, Mason G, Muller R, Miller D, 'Non-invasive RNA-based determination of fetal Rhesus D type: a prospective study based on 96 pregnancies.', British Journal of Obstetrics and Gynaecology, 1023-1028 (1999) [C1]
1999Proffitt J, Fenton J, Pratt G, Yates Z, Morgan G, 'Isolation and characterisation of recombination events involving immunoglobulin heavy chain switch regions in multiple myeloma using long distance vectorette PCR (LDV-PCR)', Leukemia, 1100-1107 (1999) [C1]
1999Fenton J, Proffitt J, Pratt G, Rawstron A, Yates Z, Davies F, et al., 'Identification of a novel translocation t(14;22)(q32;q12) in multiple myeloma.', British Journal of Cancer, (1999) [C1]
1998Pratt G, Fenton J, Proffitt J, Yates Z, Davies F, Rawstron A, et al., 'Rapid characterisation of switch recombination events from patients with multiple myeloma and the characterisation of a novel translocation t(14;22)(q32;q12): Implications for the process of switch recombination and the pathogenesis of myeloma.', Blood 92, 278., (1998) [C1]
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Conference (16 outputs)

YearCitationAltmetricsLink
2013Veysey M, Siow W, Choi J-H, Martin C, Tang S, Yates ZR, Lucock M, 'A Bitter Taste Gene (P49a Variant of Tas2r38) Interacts With A1298c-MTHFR to Modify Risk for Adenomas in an Australian Population', GASTROENTEROLOGY, Orlando, FL (2013) [E3]
2013Siow W, Niblett S, King K, Yates Z, Martin C, Lucock M, Veysey M, 'A community-based study of dietary macro and micronutrients and the risk of colorectal cancer in an elderly Australian population', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013) [E3]
2013Choi J, Siow W, Yates Z, Lucock M, Veysey M, 'Influence of synthetic folic acid concentration on Caco-2 cell growth', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013) [E3]
2013Siow W, Niblett S, King K, Yates Z, Hampe T, Lucock M, Veysey M, 'Prevalence of non-alcoholic fatty liver disease in an elderly Australian population', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013) [E3]
2011Yates ZR, Kho J, Choi J-H, Boyd L, Ng X, Skinner V, et al., 'C776G TCNII genotype influences the relationship between blood vitamin B12 and cellular folate', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
2011Choi J-H, Yates ZR, Boyd L, Veysey MJ, Lucock MD, 'Dietary folate vitamers as potential risk factors in the aetiology of adenomatous polyps', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
2011Naylor C, Lucock MD, Veysey MJ, Naumovski N, Boyd L, Dufficy L, et al., 'Folate nutritional genetics and degenerative disorders in the elderly with special reference to hypertension and depression', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
2010Chang J, Lucock MD, Wai R, Boyd L, Ng X, Skinner VM, et al., 'Dietary folic acid, red cell folate and the risk of adenomatous polyps in an Australian population', Journal of Gastroenterology and Hepatology. Special Issue: Australian Gastroenterology Week 2010, Gold Coast, QLD (2010) [E3]
2009Boyd L, Lucock MD, Wai R, Ng X, Yates ZR, Skinner V, et al., 'Folate status: A recognised determinant of colorectal neoplasia may be modified by bitter taste perception and genetics', Proceedings of the Nutrition Society of Australia, Newcastle, NSW (2009) [E3]
2009Veysey MJ, Boyd L, Wai R, Ng X, Skinner V, Tang S, et al., 'Preliminary data to support a relationship between taste genetics, folate status, folate genes and the development of colonic adenomas: A novel nutrigenomic circuit', Gastro 2009 UEGW/WCOG: Scientific Programme & EACCME, London, UK (2009) [E3]
2008Ng X, Boyd L, Dufficy L, Naumovski N, Blades BL, Travers C, et al., 'Folate genes and risk for hypertension in an elderly population sample', 3rd Asia Pacific Nutrigenomics Conference: Conference Program & Information, Melbourne, VIC (2008) [E3]
2008Yates ZR, Lucock MD, 'Folate and the C677T-MTHFR variant: Impact on population health', Journal of Nutrigenetics and Nutrigenomics, Melbourne, VIC (2008) [E3]
2008Wai RKH, Boyd L, Ng X, King K, Skinner V, Roach PD, et al., 'Preliminary evidence that bitter taste perception can modify folate status: A recognised risk factor for colorectal neoplasia', Journal of Gastroenterology and Hepatology, Brisbane, QLD (2008) [E3]
2008Boyd L, Wai RKH, Ng X, King K, Skinner V, Roach PD, et al., 'A preliminary study to examine whether common folate polymorphisms are risk factors for the development of adenomatous polyps', Journal of Gastroenterology and Hepatology, Brisbane, QLD (2008) [E3]
2004Moskovitz DN, Sohn KJ, Smirnakis F, Novakovic P, Yates ZR, Lucock MD, et al., 'Effects of folylpolyglutamyl synthetase modulation on chemosensitivity of colon cancer cells to 5 fluorouracil and methotrexate', CDDW Abstracts, Canada (2004) [E3]

Co-authors: Mark Lucock

2004Novakovic P, Sohn KJ, Chiang EP, Dickhout J, Yates Z, Lucock M, et al., 'Effect of MTHFR C677T polymorphism on the intracellular methionine cycle and DNA methylation in colon cancer cells', FASEB JOURNAL, Washington, DC (2004)
Show 13 more
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Grants and Funding

Summary

Number of grants6
Total funding$682,650

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2012 (1 grants)

Phase I and II detoxification genes; the correlation of epigenetic modifications with nutritional status, lifestyle factors, health and disease$21,000
Funding Body: CSIRO - Energy Technology

Project Team
Associate Professor Mark Lucock, Associate Professor Martin Veysey, Doctor Zoe Yates, Miss Emma Beckett, Dr Konsta Duesing
SchemeRole
Postgraduate Research ScholarshipInvestigator
Total AmountFunding StartFunding Finish
$21,00020122015
GNo:G1200845

2009 (2 grants)

The Association between Folate Nutritional Status and Folate Gene Polymorphisms in an Elderly Australian Population$61,281
Funding Body: Central Coast Local Health District

Project Team
Associate Professor Martin Veysey, Doctor Zoe Yates, Associate Professor Mark Lucock, Doctor Paul Roach
SchemeRole
Research Sponsorship ScholarshipInvestigator
Total AmountFunding StartFunding Finish
$61,28120092011
GNo:G0190658

Development of a model to study the B-vitamin related nutritional genetics of human aging$30,000
Funding Body: Ramaciotti Foundations

Project Team
Doctor Zoe Yates
SchemeRole
Establishment GrantChief Investigator
Total AmountFunding StartFunding Finish
$30,00020092009
GNo:G0189324

2007 (3 grants)

2007 Research Fellowship$550,618
Funding Body: University of Newcastle

Project Team
Doctor Zoe Yates
SchemeRole
Research FellowshipChief Investigator
Total AmountFunding StartFunding Finish
$550,61820072012
GNo:G0187072

2007 Research Fellowship Project grant$15,000
Funding Body: University of Newcastle

Project Team
Doctor Zoe Yates
SchemeRole
Fellowship GrantChief Investigator
Total AmountFunding StartFunding Finish
$15,00020072007
GNo:G0188077

Bitter taste phenotype, dietary pattern and nutritional genetics in the aetiopathology of human colonic adenoma/cancer$4,751
Funding Body: University of Newcastle

Project Team
Doctor Zoe Yates
SchemeRole
Pilot GrantChief Investigator
Total AmountFunding StartFunding Finish
$4,75120072007
GNo:G0187909
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Research Supervision

Number of current supervisions2
Total current UoN PhD EFTSL0.45

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20122016PhD (Food Science)Co-SupervisorThe Association of MIRNA Profiles and DNA Methylation with Micronutrient Intake & Status
20102014PhD (Food Science)Principal SupervisorGenotype-Phenotype Relationships Relevant to the Lifecycle with Special Reference to Vitamin Nutrition

Past Supervision

YearProgramSupervisor TypeResearch Title
2014PhD (Food Science)Principal SupervisorIn Vitro and In Vivo Approaches to the Examination of Folate-Related Nutritional Genetics in Health and Disease
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Dr Zoe Yates

Work Phone(02) 4349 4560
Fax(02) 4348 4145
Email
PositionAssociate Lecturer
Human Molecular Nutrition
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaApplied Sciences
Office
BE 137,
Health Precinct,
Ourimbah
10 Chittaway Road
Ourimbah NSW 2258
Australia
URL:www.newcastle.edu.au/profile/zoe-yates