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Associate Professor Mark Lucock

Associate Professor

School of Environmental and Life Sciences (Applied Sciences)

Career Summary

Biography

In Leeds, I established an international reputation in the field of nutritional genetics in relation to genes coding for proteins involved in folate and B-vitamin metabolism and function. I have authored a list of almost 100 publications including several reviews in high impact journals and books. In the years preceding my move to Australia in July 2003, I held around $500,000 AUD in funding including grants of $160,000 AUD from the British Heart Foundation, $145,000 AUD from Kelloggs and $85,000 AUD from the Association for Spina Bifida and Hydrocephalus.

I am also an elected Fellow of the Society of Biology (London), and a Fellow of the Royal College of Pathologists (London). My research interests cover the chemistry, nutritional biochemistry, molecular biology and genetics of B-vitamins, especially folate, and their role in the metabolism of homocysteine, which is now an acknowledged risk factor for many degenerative diseases. In particular, my research efforts are focused on common allelic variants of genes (single nucleotide polymorphisms, SNPs) that code for folate dependent enzymes and carriers.

My contribution in this area has led to improved understanding of how folate nutrition and genetics interact to modulate disease development. This work has shed light on how folate metabolism, status, nutrition and genetics impact on several disorders such as spina bifida, other serious conditions affecting pregnancy outcome, vascular disease, cancer, and neurological disorder. Two such papers for example look at the effect of folate SNPs and status on the efficacy of antifolate cancer chemotherapy in colon cancer cells. My publications span this area of interest and range from nutrient analysis and nutrient-gene interactions to the role of B-vitamins in human evolutionary processes.

My publications show considerable collaboration with British and International colleagues. Since arriving to teach in the Bachelor of Food Science & Human Nutrition program in the School of Environmental & Life Sciences (SELS) on the Ourimbah Campus of the University of Newcastle in July 2003, I have set up a well-equipped PC2 laboratory directed to molecular nutrition which includes real-time PCR equipment, LC-MS, an imaging platform and other key technologies. I have re-established my research and am now co-supervising several PhD/Honours students working in collaboration with Dr Martin Veysey (Gosford Hospital), Dr Paul Roach (SELS) and Dr Zoe Yates.

Most of these students are working in the area of B-vitamin nutrient-gene interactions and adenoma. I am the Chief facilitator for the Nutrition, Food & Health Research Group at Ourimbah. Through the School, the University and my collaborations, I have been able to access over $450,000 in set up and research funds, and am a CI on a large ARC grant with Drs Veysey and Roach. I also have an active interest in the issues associated with mandatory fortification of grain at source with synthetic folic acid. This is an area on which I have published extensively, including a recent Nature-Reviews Genetics article looking at the genetic and health implications of fortification. I am a member of the Folate Scientific Advisory Group of FSANZ looking at the implementation of mandatory folate fortification in Australia. Additionally, I have written an academic text book (July 2007) titled; Molecular Nutrition and Genomics: Nutrition & the Ascent of Humankind. This is a single author book, designed for students and researchers.

Research Expertise
Expert in the analysis, biochemistry and genetics of B-vitamins and their related proteins. Major areas of interest are the nutritional genetics of folate and how this modifies disease risk, particularly chronic degenerative diseases like CVD and bowel cancer, and developmental disorders like NTD and autism. Other major interest is the role of human nutritional genetics in human evolution.

Teaching Expertise
Course co-ordinator for three courses: Micronutrients, Nutrition through the lifecycle, and Functional foods and health claims. Deliver all material (lectures and tutorials) on all three courses

Administrative Expertise
Deputy Head of School; Complaints Officer: Served on various committees, perhaps most relevant is the Faculty Research, and Research & Traing Committee (Science & IT)

Collaborations
Folic acid chemistry, metabolism and genetics in health and disease.


Qualifications

  • PhD, University of Leeds - UK
  • Bachelor of Science (Honours), University of Bradford, UK

Keywords

  • B-Vitamins
  • Birth defects
  • Cancer
  • Folic acid
  • Functional foods and health claims
  • Micronutrients
  • Molecular Nutrition
  • Nutrient bioavailability
  • Nutrition and Human Evolution
  • Nutrition through the lifecycle
  • Nutritional Biochemistry
  • Nutritional Genetics
  • Vascular disease
  • Vitamin B12

Fields of Research

CodeDescriptionPercentage
060499Genetics not elsewhere classified30
111199Nutrition and Dietetics not elsewhere classified30
110399Clinical Sciences not elsewhere classified40

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2014 - Associate ProfessorUniversity of Newcastle
School of Environmental and Life Sciences
Australia
23/06/2011 - 23/06/2011Casual AcademicUniversity of Newcastle
School of Environmental and Life Sciences
Australia
1/09/2008 - 5/09/2008Casual AcademicUniversity of Newcastle
School of Environmental and Life Sciences
Australia
1/04/2008 - 1/04/2008Casual AcademicUniversity of Newcastle
School of Environmental and Life Sciences
Australia

Academic appointment

DatesTitleOrganisation / Department
Fellow of the Society of Biology (FSB)Society of Biology, London
United Kingdom
Fellow of the Royal College of Pathologists (MRCPath)Royal College of Pathologists, London
United Kingdom
1/01/2006 - Scientific advisor - mandatory fortification of the Australian diet with folic acidFSANZ (Food standards Australia & New Zealand)
Australia

Professional appointment

DatesTitleOrganisation / Department
Chartered Biologist (CBiol)Society of Biology, London
United Kingdom

Awards

Distinction

YearAward
2006Vice-Chancellor's Citations for Outstanding Contributions to Student Learning
University of Newcastle

Recognition

YearAward
2005Faculty of Science & IT Teaching & Learning Award
University of Newcastle

Invitations

Participant

YearTitle / Rationale
2007All invitations relate to folate
Organisation: Several both national and international Description: Invariably based on research expertise and interest in B-vitamins and health
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Book (1 outputs)

YearCitationAltmetricsLink
2007Lucock MD, Molecular Nutrition and Genomics: Nutrition and the Ascent of Mankind, John Wiley & Sons, Hoboken, 140 (2007) [A1]
DOI10.1002/9780470129388.fmatter

Chapter (1 outputs)

YearCitationAltmetricsLink
2002Lucock M, 'A differential role for folate in developmental disorders, vascular disease and other clinical conditions: the importance of folate status and genotype', , Humana Press, Totowa NJ, 263-298 (2002) [B1]

Journal article (93 outputs)

YearCitationAltmetricsLink
2015Lucock M, Yates Z, Martin C, Choi J-H, Beckett E, Boyd L, et al., 'Methylation diet and methyl group genetics in risk for adenomatous polyp occurrence', BBA Clinical, 3 107-112 (2015)

Purpose: The aim of this study is to explore whether a methylation diet influences risk for adenomatous polyps (AP) either independently, or interactively with one-carbon metaboli... [more]

Purpose: The aim of this study is to explore whether a methylation diet influences risk for adenomatous polyps (AP) either independently, or interactively with one-carbon metabolism-dependent gene variants, and whether such a diet modifies blood homocysteine, a biochemical phenotype closely related to the phenomenon of methylation. Methods: 249 subjects were examined using selective fluorescence, PCR and food frequency questionnaire to determine homocysteine, nine methylation-related gene polymorphisms, dietary methionine, 5-methyltetrahydrofolate, vitamins B6 and B12. Results: 1). Both dietary methionine and 5-methyltetrahydrofolate intake are significantly associated with plasma homocysteine. 2). Dietary methionine is related to AP risk in 2R3R-TS wildtype subjects, while dietary B12 is similarly related to this phenotype in individuals heterozygous for C1420T-SHMT, A2756G-MS and 844ins68-CBS, and in those recessive for 2R3R-TS. 3). Dietary methionine has a marginal influence on plasma homocysteine level in C1420T-SHMT heterozygotes, while B6 exhibits the same effect on homocysteine in C776G-TCN2 homozygote recessive subjects. Natural 5-methyltetrahydrofolate intake is interesting: Wildtype A1298C-MTHFR, heterozygote C677T-MTHFR, wildtype A2756G-MS and recessive A66G-MSR individuals all show a significant reciprocal association with homocysteine. 4). Stepwise regression of all genotypes to predict risk for AP indicated A2756G-MS and A66G-MSR to be most relevant (p= 0.0176 and 0.0408 respectively). Results were corrected for age and gender. Conclusion: A methylation diet influences methyl group synthesis in the regulation of blood homocysteine level, and is modulated by genetic interactions. Methylation-related nutrients also interact with key genes to modify risk of AP, a precursor of colorectal cancer. Independent of diet, two methylation-related genes (A2756G-MS and A66G-MSR) were directly associated with AP occurrence.

DOI10.1016/j.bbacli.2014.11.005
Co-authorsMartin Veysey, Zoe Yates
2015Choi JH, Yates Z, Martin C, Boyd L, Ng X, Skinner V, et al., 'Genetic Variation in Glutamate Carboxypeptidase II and Interaction with Dietary Natural Vitamin C May Predict Risk for Adenomatous Polyp Occurrence.', Asian Pac J Cancer Prev, 16 4383-4386 (2015)
Author URL
Co-authorsZoe Yates, Martin Veysey
2015Lucock M, Jones P, Martin C, Beckett E, Yates Z, Furst J, Veysey M, 'Vitamin D: Beyond Metabolism.', J Evid Based Complementary Altern Med, (2015)
DOI10.1177/2156587215580491Author URL
Co-authorsMartin Veysey, John Furst, Zoe Yates
2014Beckett EL, Yates Z, Veysey M, Duesing K, Lucock M, 'The role of vitamins and minerals in modulating the expression of microRNA.', Nutr Res Rev, 27 94-106 (2014) [C1]
DOI10.1017/S0954422414000043Author URL
Co-authorsMartin Veysey, Zoe Yates
2014Beckett EL, Martin C, Duesing K, Jones P, Furst J, Yates Z, et al., 'Vitamin D Receptor Genotype Modulates the Correlation between Vitamin D and Circulating Levels of let-7a/b and Vitamin D Intake in an Elderly Cohort.', J Nutrigenet Nutrigenomics, 7 264-273 (2014)
DOI10.1159/000381676Author URL
Co-authorsZoe Yates, John Furst, Martin Veysey
2014Beckett EL, Yates Z, Veysey M, Duesing K, Lucock M, 'The role of vitamins and minerals in modulating the expression of microRNA', Nutrition Research Reviews, 27 94-106 (2014) [C1]

A growing number of studies in recent years have highlighted the importance of molecular nutrition as a potential determinant of health and disease. In particular, the ability of ... [more]

A growing number of studies in recent years have highlighted the importance of molecular nutrition as a potential determinant of health and disease. In particular, the ability of micronutrients to regulate the final expression of gene products via modulation of transcription and translation is now being recognised. Modulation of microRNA (miRNA) by nutrients is one pathway by which nutrition may mediate gene expression. MiRNA, a class of non-coding RNA, can directly regulate gene expression post-transcriptionally. In addition, miRNA are able to indirectly influence gene expression potential at the transcriptional level via modulation of the function of components of the epigenetic machinery (DNA methylation and histone modifications). These mechanisms interact to form a complex, bi-directional regulatory circuit modulating gene expression. Disease-specific miRNA profiles have been identified in multiple disease states, including those with known dietary risk factors. Therefore, the role that nutritional components, in particular, vitamins and minerals, play in the modulation of miRNA profiles, and consequently health and disease, is increasingly being investigated, and as such is a timely subject for review. The recently posited potential for viable exogenous miRNA to enter human blood circulation from food sources adds another interesting dimension to the potential for dietary miRNA to contribute to gene modulation. © 2014 The Authors.

DOI10.1017/S0954422414000043
CitationsScopus - 1Web of Science - 1
Co-authorsMartin Veysey, Zoe Yates
2014Beckett EL, Yates Z, Veysey M, Duesing K, Lucock M, 'The role of vitamins and minerals in modulating the expression of microRNA', Nutrition Research Reviews, 27 94-106 (2014)
DOI10.1017/S0954422414000043
Co-authorsZoe Yates, Martin Veysey
2014Beckett EL, Martin C, Duesing K, Jones P, Furst J, Yates Z, et al., 'Vitamin D receptor genotype modulates the correlation between vitamin D and circulating levels of let-7a/b and vitamin D intake in an elderly cohort', Journal of Nutrigenetics and Nutrigenomics, 7 264-273 (2014)

Background and Aims: Circulating microRNAs (miRNAs) are linked to disease and are potential biomarkers. Vitamin D may modulate miRNA profiles, and vitamin D status has been linked... [more]

Background and Aims: Circulating microRNAs (miRNAs) are linked to disease and are potential biomarkers. Vitamin D may modulate miRNA profiles, and vitamin D status has been linked to risk of disease, including cardiovascular disease and cancers. We hypothesise that genotypic variance influences these relationships. We examined the correlations between vitamin D intake and circulating levels of the miRNAs let-7a/b, and the involvement of two common vitamin D receptor (VDR) polymorphisms, BsmI and ApaI. Methods: Two hundred participants completed food frequency and supplement questionnaires, and were assayed for circulating let-7b expression by qPCR. Polymorphisms were detected using restriction fragment length polymorphism-PCR. Results: let-7b expression negatively correlated with vitamin D intake (rs = -0.20, p = 0.005). The magnitude and direction of correlation were maintained in the presence of the BsmI restriction site (rs = -0.27, p = 0.0005). However, in the absence of BsmI restriction site, the direction of the correlation was reversed (rs = +0.319, p = 0.0497). These correlations were significantly different (z-score = 2.64, p = 0.0085). The correlation between vitamin D intake and let-7a was only significant in those without the ApaI restriction site. Conclusions: The correlation between vitamin D intake and let-7a/b expression in this cohort varies with VDR genotype. This study highlights the importance of considering underlying genotypic variance in miRNA expression studies and in nutritional epigenetics generally.

DOI10.1159/000381676
Co-authorsJohn Furst, Martin Veysey
2014Beckett EL, Martin C, Yates Z, Veysey M, Duesing K, Lucock M, 'Bitter taste genetics-the relationship to tasting, liking, consumption and health', Food and Function, 5 3040-3054 (2014) [C1]

Bitter is the most complex of human tastes, and is arguably the most important. Aversion to bitter taste is important for detecting toxic compounds in food; however, many benefici... [more]

Bitter is the most complex of human tastes, and is arguably the most important. Aversion to bitter taste is important for detecting toxic compounds in food; however, many beneficial nutrients also taste bitter and these may therefore also be avoided as a consequence of bitter taste. While many polymorphisms in TAS2R genes may result in phenotypic differences that influence the range and sensitivity of bitter compounds detected, the full extent to which individuals differ in their abilities to detect bitter compounds remains unknown. Simple logic suggests that taste phenotypes influence food preferences, intake and consequently health status. However, it is becoming clear that genetics only plays a partial role in predicting preference, intake and health outcomes, and the complex, pleiotropic relationships involved are yet to be fully elucidated. This journal is

DOI10.1039/c4fo00539b
Co-authorsZoe Yates, Martin Veysey
2014Lucock MD, Martin CE, Yates ZR, Veysey M, 'Diet and Our Genetic Legacy in the Recent Anthropocene: A Darwinian Perspective to Nutritional Health', Journal of Evidence-Based Complementary and Alternative Medicine, 19 68-83 (2014) [C1]

Nutrient-gene research tends to focus on human disease, although such interactions are often a by-product of our evolutionary heritage. This review explores health in this context... [more]

Nutrient-gene research tends to focus on human disease, although such interactions are often a by-product of our evolutionary heritage. This review explores health in this context, reframing genetic variation/epigenetic phenomena linked to diet in the framework of our recent evolutionary past. This "Darwinian/evolutionary medicine" approach examines how diet helped us evolve among primates and to adapt (or fail to adapt) our metabolome to specific environmental conditions leading to major diseases of civilization. This review presents updated evidence from a diet-gene perspective, portraying discord that exists with respect to health and our overall nutritional, cultural, and activity patterns. While Darwinian theory goes beyond nutritional considerations, a significant component within this concept does relate to nutrition and the mismatch between genes, modern diet, obesogenic lifestyle, and health outcomes. The review argues that nutritional sciences should expand knowledge on the evolutionary connection between food and disease, assimilating it into clinical training with greater prominence. © The Author(s) 2013.

DOI10.1177/2156587213503345
CitationsScopus - 3
Co-authorsZoe Yates, Martin Veysey
2014Choi J-H, Yates Z, Veysey M, Heo Y-R, Lucock M, 'Contemporary issues surrounding folic acid fortification initiatives', Preventive Nutrition and Food Science, 19 247-260 (2014) [C1]

The impact of folate on health and disease, particularly pregnancy complications and congenital malformations, has been extensively studied. Mandatory folic acid fortification the... [more]

The impact of folate on health and disease, particularly pregnancy complications and congenital malformations, has been extensively studied. Mandatory folic acid fortification therefore has been implemented in multiple countries, resulting in a reduction in the occurrence of neural tube defects. However, emerging evidence suggests increased folate intake may also be associated with unexpected adverse effects. This literature review focuses on contemporary issues of concern, and possible underlying mechanisms as well as giving consideration the future direction of mandatory folic acid fortification. Folate fortification has been associated with the presence of unmetabolized folic acid (PteGlu) in blood, masking of vitamin B12 deficiency, increased dosage for anti-cancer medication, photo-catalysis of PteGlu leading to potential genotoxicity, and a role in the pathoaetiology of colorectal cancer. Increased folate intake has also been associated with twin birth and insulin resistance in offspring, and altered epigenetic mechanisms of inheritance. Although limited data exists to elucidate potential mechanisms underlying these issues, elevated blood folate level due to the excess use of PteGlu without consideration of an individual's specific phenotypic traits (e.g. genetic background and undiagnosed disease) may be relevant. Additionally, the accumulation of unmetabolized PteGlu may lead to inhibition of dihydrofolate reductase and other enzymes. Concerns notwithstanding, folic acid fortification has achieved enormous advances in public health. It therefore seems prudent to target and carefully monitor high risk groups, and to conduct well focused further research to better understand and to minimize any risk of mandatory folic acid fortification.

DOI10.3746/pnf.2014.19.4.247
Co-authorsMartin Veysey, Zoe Yates
2014Lucock M, Yates Z, Martin C, Choi JH, Boyd L, Tang S, et al., 'Vitamin D, folate, and potential early lifecycle environmental origin of significant adult phenotypes.', Evolution, Medicine, and Public Health, 2014 69-91 (2014) [C1]
DOI10.1093/emph/eou013
Co-authorsZoe Yates, Martin Veysey, Paul Roach, John Furst
2014Beckett EL, Martin C, Yates Z, Veysey M, Duesing K, Lucock M, 'Bitter taste genetics--the relationship to tasting, liking, consumption and health.', Food Funct, 5 3040-3054 (2014) [C1]
DOI10.1039/c4fo00539bAuthor URL
Co-authorsMartin Veysey, Zoe Yates
2014Martin CE, Veysey M, Yates Z, Lucock MD, 'Vitamin D: Genetics, Environment & Health', Food and Nutritional Disorders, 3 1-19 (2014) [C1]
DOI10.4172/2324-9323.1000155
Co-authorsMartin Veysey, Zoe Yates
2013Lucock M, Leeming R, 'Autism, seasonality and the environmental perturbation of epigenome related vitamin levels', Medical Hypotheses, 80 750-755 (2013) [C1]
DOI10.1016/j.mehy.2013.03.003Author URL
CitationsScopus - 1
2013Lucock MD, Martin C, Boyd L, Naumovski N, Roach P, Yates Z, Veysey M, 'Response to 'calcium, phosphate and the risk of cardiovascular events and all-cause mortality in a population with stable coronary heart disease'', HEART, 99 349-350 (2013) [C3]
DOI10.1136/heartjnl-2012-302480Author URL
Co-authorsZoe Yates, Paul Roach, Martin Veysey
2013Lucock M, Yates Z, Boyd L, Naylor C, Choi J, Ng X, et al., 'Vitamin C-related nutrient-nutrient and nutrient-gene interactions that modify folate status', European Journal of Nutrition, 52 569-582 (2013) [C1]
DOI10.1007/s00394-012-0359-8Author URL
CitationsScopus - 8Web of Science - 3
Co-authorsZoe Yates, Paul Roach, Martin Veysey
2013Lucock M, Yates Z, Martin C, Choi J, Boyd L, Tang S, et al., 'Hydrogen sulphide-related thiol metabolism and nutrigenetics in relation to hypertension in an elderly population', Genes & Nutrition, 8 221-229 (2013) [C1]
DOI10.1007/s12263-012-0317-3Author URL
CitationsScopus - 2Web of Science - 1
Co-authorsPaul Roach, Zoe Yates, Martin Veysey
2012Lucock MD, 'Dietary supplements and altered mortality: A conflict of evolutionary medicine', Archives of Internal Medicine, 172 448-449 (2012) [C3]
CitationsScopus - 2Web of Science - 1
2012Lucock MD, Glanville T, Yates ZR, Walker J, Furst JE, Simpson N, 'Solar cycle predicts folate-sensitive neonatal genotypes at discrete phases of the first trimester of pregnancy: A novel folate-related human embryo loss hypothesis', Medical Hypotheses, 79 210-215 (2012) [C1]
CitationsScopus - 5Web of Science - 4
Co-authorsJohn Furst, Zoe Yates
2011Lucock MD, Ng X, Boyd L, Skinner VM, Wai R, Tang S, et al., 'TAS2R38 bitter taste genetics, dietary vitamin C, and both natural and synthetic dietary folic acid predict folate status, a key micronutrient in the pathoaetiology of adenomatous polyps', Food & Function, 2 457-465 (2011) [C1]
DOI10.1039/c1fo10054h
CitationsScopus - 7Web of Science - 5
Co-authorsPaul Roach, Martin Veysey, Zoe Yates
2011Lucock M, 'Folic acid: Beyond metabolism', Journal of Evidence-Based Complementary and Alternative Medicine, 16 102-113 (2011) [C3]

Mandatory and discretionary fortification with folic acid is eliminating deficiency of this vitamin. Blood levels of the vitamin have never been higher, with hematologic folate va... [more]

Mandatory and discretionary fortification with folic acid is eliminating deficiency of this vitamin. Blood levels of the vitamin have never been higher, with hematologic folate values commonly exceeding the upper range of calibration. The synthetic analog (pteroylmonoglutamic acid) prevents neural tube defects and lowers homocysteine, both positive attributes, yet negative correlates of pteroylmonoglutamic acid are increasingly reported. These involve increased risk for common cancers (ie, colon, breast, prostate) and antimetabolite effects on natural killer cells and at dihydrofolate reductase, a critical gatekeeper enzyme. This review, however, takes a different, human ecological perspective, examining novel folate-related phenomena distinct from the classic metabolic role of the vitamin in maintaining health and well-being. An argument is developed that at molecular, cellular, and organism levels, folate is crucial to some important events that link light to life. © The Author(s) 2011.

CitationsScopus - 1
2011Lucock MD, 'Folic acid: Beyond metabolism', Journal of Evidence-Based Complementary and Alternative Medicine, 16 102-113 (2011) [C1]
CitationsScopus - 5
2010Lucock MD, Glanville T, Ovadia L, Yates ZR, Walker J, Simpson N, 'Photoperiod at conception predicts C677T-MTHFR genotype: A novel gene-environment interaction', American Journal of Human Biology, 22 484-489 (2010) [C1]
DOI10.1002/ajhb.21022
CitationsScopus - 11Web of Science - 7
Co-authorsZoe Yates
2010Naumovski N, Veysey M, Ng X, Boyd L, Dufficy L, Blades BL, et al., 'The folic acid endophenotype and depression in an elderly population', Journal of Nutrition, Health and Aging, 14 829-833 (2010) [C1]
DOI10.1007/s12603-010-0135-5
CitationsScopus - 3Web of Science - 2
Co-authorsMaureen Townley-Jones, Paul Roach, Martin Veysey, Zoe Yates
2009Ng X, Boyd L, Dufficy L, Naumovski N, Blades BL, Travers C, et al., 'Folate nutritional genetics and risk for hypertension in an elderly population sample', Journal of Nutrigenetics and Nutrigenomics, 2 1-8 (2009) [C1]
DOI10.1159/000160079
CitationsScopus - 11Web of Science - 9
Co-authorsMaureen Townley-Jones, Paul Roach, Martin Veysey, Zoe Yates
2009Smith DR, Lucock MD, 'Should folate supplements be integrated with workplace nutrition programs?', Industrial Health, 47 449-451 (2009) [C3]
DOI10.2486/indhealth.47.449
CitationsScopus - 1Web of Science - 1
Co-authorsDerek Smith
2009Leeming RJ, Lucock MD, 'Autism: Is there a folate connection?', Journal of Inherited Metabolic Disease, 32 400-402 (2009) [C2]
DOI10.1007/s10545-009-1093-0
CitationsScopus - 6Web of Science - 4
2009Sohn K-J, Jang H, Campan M, Weisenberger DJ, Dickhout J, Wang Y-C, et al., 'The methylenetetrahydrofolate reductase C677T mutation induces cell-specific changes in genomic DNA methylation and uracil misincorporation: A possible molecular basis for the site-specific cancer risk modification', International Journal of Cancer, 124 1999-2005 (2009) [C1]
DOI10.1002/ijc.24003
CitationsScopus - 42Web of Science - 42
Co-authorsZoe Yates
2009Lucock MD, Yates ZR, 'Folic acid fortification: A double-edged sword', Current Opinion in Clinical Nutrition & Metabolic Care, 12 555-564 (2009) [C1]
DOI10.1097/mco.0b013e32833192bc
CitationsScopus - 40Web of Science - 31
Co-authorsZoe Yates
2008Ng X, Lucock M, Veysey M, 'Physicochemical effect of pH and antioxidants on mono- and triglutamate forms of 5-methyltetrahydrofolate, and evaluation of vitamin stability in human gastric juice: Implications for folate bioavailability (vol 106, pg 200, 2008)', FOOD CHEMISTRY, 110 1000-1000 (2008) [C3]
DOI10.1016/j.foodchem.2008.04.001Author URL
Co-authorsMartin Veysey
2008Ng X, Lucock MD, Veysey MJ, 'Physicochemical effect of pH and antioxidants on mono- and triglutamate forms of 5-methyltetrahydrofolate, and evaluation of vitamin stability in human gastric juice: Implications for folate bioavailability', Food Chemistry, 106 200-210 (2008) [C1]
DOI10.1016/j.foodchem.2007.05.057
CitationsScopus - 11Web of Science - 9
Co-authorsMartin Veysey
2007Adams MC, Lucock MD, Stuart JE, Fardell S, Baker K, Ng X, 'Preliminary evidence for involvement of the folate gene polymorphism 19 bp deletion-DHFR in occurrence of autism', Neuroscience Letters, 422 24-29 (2007) [C1]
DOI10.1016/j.neulet.2007.05.025
CitationsScopus - 25Web of Science - 23
Co-authorsJohn Stuart
2007Lucock MD, Yates ZR, Ng X, Veysey MJ, Blades BL, Travers C, et al., 'Preliminary evidence for genetic selection of 677T-MTHFR by natural annual cycle of folate abundance', Journal of Nutrigenetics and Nutrigenomics, 1 24-29 (2007) [C1]
DOI10.1159/000109872
CitationsScopus - 10Web of Science - 8
Co-authorsPaul Roach, Martin Veysey, Zoe Yates
2006Dufficy L, Naumovski N, Ng X, Blades BL, Yates ZR, Travers C, et al., 'G80A reduced folate carrier SNP influences the absorption and cellular translocation of dietary folate and its association with blood pressure in an elderly population', Life Sciences, 79 957-966 (2006) [C1]
DOI10.1016/j.lfs.2006.05.009
CitationsScopus - 19Web of Science - 19
Co-authorsPaul Roach, Martin Veysey, Zoe Yates
2006Glanville T, Yates ZR, Ovadia L, Walker JJ, Lucock MD, Simpson NAB, 'Fetal folate C677T methylenetetrahydrofolate reductase gene polymorphism and low birth weight', Journal of Obstetrics and Gynaecology, 26 11-14 (2006) [C1]
DOI10.1080/01443610500363865
CitationsScopus - 10
Co-authorsZoe Yates
2006Lucock MD, Yates ZR, 'Synergy between 677 TT MTHFR genotype and related folate SNPs regulates homocysteine level', Nutrition Research, 26 180-185 (2006) [C1]
DOI10.1016/j.nutres.2006.01.001
CitationsScopus - 6Web of Science - 6
Co-authorsZoe Yates
2006Lucock MD, 'Synergy of genes and nutrients: The case of homocysteine', Current Opinion in Clinical Nutrition and Metabolic Care, 9 748-756 (2006) [C1]
DOI10.1097/01.mco.0000247468.18790.1e
CitationsScopus - 20Web of Science - 15
2005Lucock MD, Ng X, Veysey MJ, Yates ZR, 'Folic acid: An essential nutrient with added health benefits', Biologist, 52 21-27 (2005) [C1]
CitationsScopus - 2
Co-authorsZoe Yates, Martin Veysey
2005Lucock MD, Roach PD, 'The antifolate activity of tea catechins (letter)', Cancer Research, 65 8573-8573 (2005) [C3]
CitationsScopus - 4Web of Science - 3
Co-authorsPaul Roach
2005Yates ZR, Lucock MD, 'G80A reduced folate carrier SNP modulates cellular uptake of folate and affords protection against thrombosis via a non homocysteine related mechanism', Life Sciences, 77 2735-2742 (2005) [C1]
DOI10.1016/j.lfs.2005.02.029
CitationsScopus - 31Web of Science - 31
Co-authorsZoe Yates
2005Lucock MD, Yates ZR, 'Human genetic selection by folates', Nature Reviews Genetics, 6 online (2005) [C3]
Co-authorsZoe Yates
2004Sohn K-J, Smirnakis F, Moskovitz DN, Novakovic P, Yates ZR, Lucock MD, et al., 'Effects of folylpolyglutamate synthetase modulation on chemosensitivity of colon cancer cells to 5-fluorouracil and methotrexate', GUT, 53 1825-1831 (2004) [C1]
DOI10.1136/gut.2004.042713
CitationsScopus - 18Web of Science - 17
Co-authorsZoe Yates
2004Blackburn A, Bibby MC, Lucock MD, Nicolaou A, 'Temporal evaluation of methionine synthase and related metabolites in the MAC15A mouse adenocarcinoma animal model', International Journal of Cancer, 112 577-584 (2004) [C1]
DOI10.1002/ijc.20451
CitationsScopus - 3Web of Science - 2
2004Sohn K-J, Croxford R, Yates ZR, Lucock MD, Kim Y-I, 'Effect of the methylenetetrahydrofolate reductase C677T polymorphism on chemosensitivity of colon and breast cancer cells to 5-fluorouracil and methotrexate', Journal of the National Cancer Institute, 96 134-144 (2004) [C1]
DOI10.1093/jnci/djh
CitationsScopus - 155Web of Science - 148
Co-authorsZoe Yates
2004Lucock MD, 'Is folic acid the ultimate functional food component for disease prevention?', British Medical Journal, 328 211-214 (2004) [C1]
DOI10.1136/bmj.328.7433.211
CitationsWeb of Science - 96
2004Lucock M, 'Science, medicine, and the future: Is folic acid the ultimate functional food component for disease prevention?', British Medical Journal, 328 211-214 (2004)
CitationsScopus - 116
2004Lucock MD, 'Is folic acid the ultimate functional food component for disease prevention?', BMJ USA, 4 127-130 (2004) [C1]
2003Lucock MD, Yates ZR, Glanville T, Leeming R, Simpson N, Daskalakis I, 'A critical role for B-vitamin nutrition in human developmental and evolutionary biology', Nutrition Research, 23 1463-1475 (2003) [C1]
DOI10.1016/S0271-5317(03)00156-8
CitationsScopus - 40Web of Science - 26
Co-authorsZoe Yates
2003Yates Z, Lucock M, 'Interaction between common folate polymorphisms and B-vitamin nutritional status modulates homocysteine and risk for a thrombotic event', MOLECULAR GENETICS AND METABOLISM, 79 201-213 (2003) [C1]
DOI10.1016/S1096-7192(03)00093-3Author URL
CitationsScopus - 16Web of Science - 15
Co-authorsZoe Yates
2002Lucock M, Yates Z, 'Correspondence: Measurement of red blood cell methylfolate', Lancet, 360 (2002) [C3]
2002Lucock M, Yates Z, 'Measurement of red blood cell methylfolate', LANCET, 360 1021-1022 (2002) [C1]
DOI10.1016/S0140-6736(02)11105-6Author URL
CitationsScopus - 8Web of Science - 5
Co-authorsZoe Yates
2002Yates Z, Lucock M, 'Methionine synthase, polymorphism A2756G is associated with susceptibility for thromboembolic events and altered B vitamin/thiol metabolism', HAEMATOLOGICA, 87 751-756 (2002) [C1]
Author URL
CitationsScopus - 18Web of Science - 18
Co-authorsZoe Yates
2002Lucock M, Yates Z, Hall K, Leeming R, Rylance G, MacDonald A, Green A, 'The impact of phenylketonuria on folate metabolism', MOLECULAR GENETICS AND METABOLISM, 76 305-312 (2002) [C1]
DOI10.1016/S1096-7192(02)00113-0Author URL
CitationsScopus - 12Web of Science - 10
Co-authorsZoe Yates
2002Lucock M, Yates Z, Hall K, Leeming R, Rylance G, MacDonald A, Green A, 'The impact of phenylketonuria on folate metabolism', Molecular Genetics and Metabolism, 1096-7206 (2002) [C1]
2001Lucock M, Daskalakis I, Yates Z, 'C677T MTHFR genotypes show graded response to vitamin B-12 dependent regeneration of tetrahydrofolate, the main congener of all cellular folates', NUTRITION RESEARCH, 21 1357-1362 (2001) [C1]
DOI10.1016/S0271-5317(01)00345-1Author URL
CitationsScopus - 2Web of Science - 1
Co-authorsZoe Yates
2001Lucock M, Yates Z, Daskalakis I, 'C677T MTHFR genotypes show graded response to vitamin B12 dependent regeneration of tetrahydrofolate, the main congenor of all cellular folates', Nutrition Research, 0271-5317 (2001) [C1]
2001Lucock M, Daskalakis I, Hinkins M, Yates Z, 'An examination of polymorphic genes and folate metabolism in mothers affected by a spina bifida pregnancy', MOLECULAR GENETICS AND METABOLISM, 73 322-332 (2001) [C1]
DOI10.1006/mgme.2001.3205Author URL
CitationsScopus - 26Web of Science - 25
Co-authorsZoe Yates
2001Lucock M, Daskalakis I, Hinkins M, Yates Z, 'An examination of polymorphic genes and folate metabolism in mothers affected by a spina bifida pregnancy', Molecular Genetics and Metabolism, 1096-7206 (2001) [C1]
2000Lucock M, Daskalakis I, 'New perspectives on folate status: a differential role for the vitamin in cardiovascular disease, birth defects and other conditions', BRITISH JOURNAL OF BIOMEDICAL SCIENCE, 57 254-260 (2000)
Author URL
CitationsScopus - 18Web of Science - 14
2000Lucock M, Daskalakis I, Briggs D, Yates Z, Levene M, 'Altered folate metabolism and disposition in mothers affected by a spina bifida pregnancy: Influence of 677c -> t methylenetetrahydrofolate reductase and 2756a -> g methionine synthase genotypes', MOLECULAR GENETICS AND METABOLISM, 70 27-44 (2000) [C1]
DOI10.1006/mgme.2000.2994Author URL
CitationsScopus - 37Web of Science - 36
Co-authorsZoe Yates
2000Lucock M, 'Folic acid: Nutritional biochemistry, molecular biology, and role in disease processes', MOLECULAR GENETICS AND METABOLISM, 71 121-138 (2000)
DOI10.1006/mgme.2000.3027Author URL
CitationsScopus - 394Web of Science - 353
1999Lucock MD, Daskalakis I, Schorah CJ, Lumb CH, Oliver M, Devitt H, et al., 'Folate-homocysteine interrelations: Potential new markers of folate status', MOLECULAR GENETICS AND METABOLISM, 67 23-35 (1999)
DOI10.1006/mgme.1999.2813Author URL
CitationsScopus - 21Web of Science - 21
1998Schorah CJ, Devitt H, Lucock M, Dowell AC, 'The responsiveness of plasma homocysteine to small increases in dietary folic acid: a primary care study', EUROPEAN JOURNAL OF CLINICAL NUTRITION, 52 407-411 (1998)
DOI10.1038/sj.ejcn.1600576Author URL
CitationsScopus - 65Web of Science - 53
1998Lucock MD, Daskalakis I, Lumb CH, Schorah CJ, Levene MI, 'Impaired regeneration of monoglutamyl tetrahydrofolate leads to cellular folate depletion in mothers affected by a spina bifida pregnancy', MOLECULAR GENETICS AND METABOLISM, 65 18-30 (1998)
DOI10.1006/mgme.1998.2738Author URL
CitationsScopus - 20Web of Science - 19
1997Lucock MD, Wild J, Lumb CH, Oliver M, Kendall R, Daskalakis I, et al., 'Risk of neural tube defect-affected pregnancy is associated with a block in maternal one-carbon metabolism at the level of N-5-methyltetrahydrofolate:homocysteine methyltransferase', BIOCHEMICAL AND MOLECULAR MEDICINE, 61 28-40 (1997)
DOI10.1006/bmme.1997.2580Author URL
CitationsScopus - 22Web of Science - 21
1996Schorah CJ, Wild J, Lucock M, 'Folate dose may mask small differences in folate metabolism', AMERICAN JOURNAL OF CLINICAL NUTRITION, 63 976-976 (1996)
Author URL
1996Daskalakis I, Lucock MD, Anderson A, Wild J, Schorah CJ, Levene MI, 'Determination of plasma total homocysteine and cysteine using HPLC with fluorescence detection and an ammonium 7-fluoro-2,1,3-benzoxadiazole-4-sulphonate (SBD-F) derivatization protocol optimized for antioxidant concentration, derivatization reagent concentration, temperature and matrix pH', BIOMEDICAL CHROMATOGRAPHY, 10 205-212 (1996)
DOI10.1002/(SICI)1099-0801(199609)10:5<205::AID-BMC589>3.3.CO;2-GAuthor URL
CitationsScopus - 48Web of Science - 46
1996Lucock MD, Daskalakis I, Schorah CJ, Levene MI, Hartley R, 'Analysis and biochemistry of blood folate', BIOCHEMICAL AND MOLECULAR MEDICINE, 58 93-112 (1996)
DOI10.1006/bmme.1996.0037Author URL
CitationsScopus - 16Web of Science - 17
1996Lucock MD, Daskalakis IG, Wild J, Anderson A, Schorah CJ, Lean MEJ, Levene MI, 'The influence of dietary folate and methionine on the metabolic disposition of endotoxic homocysteine', BIOCHEMICAL AND MOLECULAR MEDICINE, 59 104-111 (1996)
DOI10.1006/bmme.1996.0074Author URL
CitationsScopus - 18Web of Science - 19
1995LUCOCK MD, GREEN M, PRIESTNALL M, DASKALAKIS I, LEVENE MI, HARTLEY R, 'OPTIMIZATION OF CHROMATOGRAPHIC CONDITIONS FOR THE DETERMINATION OF FOLATES IN FOODS AND BIOLOGICAL TISSUES FOR NUTRITIONAL AND CLINICAL-WORK', FOOD CHEMISTRY, 53 329-338 (1995)
DOI10.1016/0308-8146(95)93941-JAuthor URL
CitationsScopus - 31Web of Science - 31
1995LUCOCK MD, GREEN M, LEVENE MI, 'METHYLFOLATE MODULATES POTASSIUM-EVOKED NEURO-SECRETION - EVIDENCE FOR A ROLE AT THE PTERIDINE COFACTOR LEVEL OF TYROSINE 3-HYDROXYLASE', NEUROCHEMICAL RESEARCH, 20 727-736 (1995)
DOI10.1007/BF01705542Author URL
CitationsScopus - 8Web of Science - 6
1995LUCOCK MD, PRIESTNALL M, DASKALAKIS I, SCHORAH CJ, WILD J, LEVENE MI, 'NONENZYMATIC DEGRADATION AND SALVAGE OF DIETARY-FOLATE - PHYSICOCHEMICAL FACTORS LIKELY TO INFLUENCE BIOAVAILABILITY', BIOCHEMICAL AND MOLECULAR MEDICINE, 55 43-53 (1995)
DOI10.1006/bmme.1995.1030Author URL
CitationsScopus - 38Web of Science - 32
1995WILD J, LUCOCK MD, SCHORAH CJ, 'PERICONCEPTIONAL FOLATE AND NEURAL-TUBE DEFECTS', AMERICAN JOURNAL OF CLINICAL NUTRITION, 61 615-616 (1995)
Author URL
CitationsWeb of Science - 1
1995HABIBZADEH N, WILD J, LUCOCK MD, SCHORAH CJ, 'ONE-CARBON METABOLISM IN PREGNANCIES COMPLICATED BY NEURAL-TUBE DEFECTS', LANCET, 345 791-791 (1995)
DOI10.1016/S0140-6736(95)90669-XAuthor URL
CitationsScopus - 2
1995LUCOCK MD, WILD J, LEVENE MI, 'ENZYME DEFECT AS A RISK FACTOR FOR SPINA-BIFIDA', LANCET, 346 1495-1496 (1995)
DOI10.1016/S0140-6736(95)92517-1Author URL
CitationsScopus - 5Web of Science - 5
1994LUCOCK MD, NAYEEMUDDIN FA, HABIBZADEH N, SCHORAH CJ, HARTLEY R, LEVENE MI, 'METHYLFOLATE EXHIBITS A NEGATIVE IN-VITRO INTERACTION WITH IMPORTANT DIETARY METAL-CATIONS', FOOD CHEMISTRY, 50 307-310 (1994)
DOI10.1016/0308-8146(94)90138-4Author URL
CitationsScopus - 5Web of Science - 5
1994LUCOCK MD, WILD J, SCHORAH CJ, LEVENE MI, HARTLEY R, 'THE METHYLFOLATE AXIS IN NEURAL-TUBE DEFECTS - IN-VITRO CHARACTERIZATION AND CLINICAL INVESTIGATION', BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY, 52 101-114 (1994)
DOI10.1006/bmmb.1994.1040Author URL
CitationsScopus - 36Web of Science - 32
1993LUCOCK MD, GREEN M, HARTLEY R, LEVENE MI, 'PHYSICOCHEMICAL AND BIOLOGICAL FACTORS INFLUENCING METHYLFOLATE STABILITY - USE OF DITHIOTHREITOL FOR HPLC ANALYSIS WITH ELECTROCHEMICAL DETECTION', FOOD CHEMISTRY, 47 79-86 (1993)
DOI10.1016/0308-8146(93)90307-2Author URL
CitationsScopus - 11Web of Science - 13
1993LUCOCK MD, LEVENE MI, HARTLEY R, 'MODULATION OF POTASSIUM EVOKED SECRETORY FUNCTION IN RAT CEREBELLAR SLICES MEASURED BY REAL-TIME MONITORING - EVIDENCE OF A POSSIBLE ROLE FOR METHYLFOLATE IN CEREBRAL TISSUE', NEUROCHEMICAL RESEARCH, 18 617-623 (1993)
DOI10.1007/BF00966940Author URL
CitationsScopus - 6Web of Science - 6
1991LUCOCK MD, WILD J, HARTLEY R, LEVENE MI, SCHORAH CJ, 'VITAMINS TO PREVENT NEURAL-TUBE DEFECTS', LANCET, 338 894-895 (1991)
Author URL
CitationsScopus - 1Web of Science - 3
1991HARTLEY R, GREEN M, LUCOCK MD, RYAN S, FORSYTHE WI, 'SOLID-PHASE EXTRACTION OF OXCARBAZEPINE AND ITS METABOLITES FROM PLASMA FOR ANALYSIS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY', BIOMEDICAL CHROMATOGRAPHY, 5 212-215 (1991)
DOI10.1002/bmc.1130050507Author URL
CitationsScopus - 15Web of Science - 12
1991HARTLEY R, FORSYTHE WI, MCLAIN B, NG PC, LUCOCK MD, 'DAILY VARIATIONS IN STEADY-STATE PLASMA-CONCENTRATIONS OF CARBAMAZEPINE AND ITS METABOLITES IN EPILEPTIC CHILDREN', CLINICAL PHARMACOKINETICS, 20 237-244 (1991)
Author URL
CitationsScopus - 14Web of Science - 20
1990HARTLEY R, LUCOCK MD, NG PC, FORSYTHE WI, MCLAIN B, BOWMER CJ, 'FACTORS INFLUENCING PLASMA-LEVEL DOSE RATIOS OF CARBAMAZEPINE AND ITS MAJOR METABOLITES IN EPILEPTIC CHILDREN', THERAPEUTIC DRUG MONITORING, 12 438-444 (1990)
DOI10.1097/00007691-199009000-00006Author URL
CitationsScopus - 12Web of Science - 17
1989LUCOCK MD, HARTLEY R, SMITHELLS RW, 'A RAPID AND SPECIFIC HPLC-ELECTROCHEMICAL METHOD FOR THE DETERMINATION OF ENDOGENOUS 5-METHYLTETRAHYDROFOLIC ACID IN PLASMA USING SOLID-PHASE SAMPLE PREPARATION WITH INTERNAL STANDARDIZATION', BIOMEDICAL CHROMATOGRAPHY, 3 58-63 (1989)
DOI10.1002/bmc.1130030204Author URL
CitationsScopus - 34Web of Science - 35
1989LUCOCK MD, WILD J, SMITHELLS RW, HARTLEY R, 'INVIVO CHARACTERIZATION OF THE ABSORPTION AND BIOTRANSFORMATION OF PTEROYLMONOGLUTAMIC ACID IN MAN - A MODEL FOR FUTURE STUDIES', BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY, 42 30-42 (1989)
DOI10.1016/0885-4505(89)90038-8Author URL
CitationsScopus - 36Web of Science - 35
1989LUCOCK M, WILD J, SMITHELLS R, HARTLEY R, 'BIOTRANSFORMATION OF PTEROYLMONOGLUTAMIC ACID DURING ABSORPTION - IMPLICATIONS OF MICHAELIS-MENTEN KINETICS', EUROPEAN JOURNAL OF CLINICAL NUTRITION, 43 631-635 (1989)
Author URL
CitationsScopus - 21Web of Science - 24
1987LUCOCK M, HARTLEY R, WILD NJ, 'HPLC DETERMINATION OF VITAMIN-K1 IN NEONATAL PLASMA FOLLOWING ORAL OR PARENTERAL SUPPLEMENTATION WITH KONAKION', JOURNAL OF LIQUID CHROMATOGRAPHY, 10 191-203 (1987)
DOI10.1080/01483918708074200Author URL
CitationsScopus - 3Web of Science - 4
1987HARTLEY R, LUCOCK M, FORSYTHE WI, SMITHELLS RW, 'SOLID-PHASE EXTRACTION OF CARBAMAZEPINE AND 2 MAJOR METABOLITES FROM PLASMA FOR ANALYSIS BY HPLC', JOURNAL OF LIQUID CHROMATOGRAPHY, 10 2393-2409 (1987)
DOI10.1080/01483918708068920Author URL
CitationsScopus - 6Web of Science - 15
1987HARTLEY R, LUCOCK M, BECKER M, 'IMPROVED HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC PROCEDURE FOR THE DETERMINATION OF CHLORMETHIAZOLE LEVELS FOLLOWING SOLID-PHASE EXTRACTION FROM PLASMA', JOURNAL OF CHROMATOGRAPHY-BIOMEDICAL APPLICATIONS, 415 357-364 (1987)
DOI10.1016/S0378-4347(00)83227-2Author URL
CitationsScopus - 4Web of Science - 5
1986PICKARD CE, STEWART AD, HARTLEY R, LUCOCK MD, 'A RAPID HPLC METHOD FOR MONITORING PLASMA-LEVELS OF CAFFEINE AND THEOPHYLLINE USING SOLID-PHASE EXTRACTION COLUMNS', ANNALS OF CLINICAL BIOCHEMISTRY, 23 440-446 (1986)
Author URL
CitationsScopus - 22Web of Science - 29
1986HARTLEY R, LUCOCK M, BECKER M, SMITH IJ, FORSYTHE WI, 'SOLID-PHASE EXTRACTION OF ACETAZOLAMIDE FROM BIOLOGICAL-FLUIDS AND SUBSEQUENT ANALYSIS BY HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHY', JOURNAL OF CHROMATOGRAPHY, 377 295-305 (1986)
DOI10.1016/S0378-4347(00)80785-9Author URL
CitationsScopus - 19Web of Science - 23
1986HARTLEY R, LUCOCK M, COOKMAN J, BECKER M, SMITH IJ, SMITHELLS RW, FORSYTHE WI, 'HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF CARBAMAZEPINE AND CARBAMAZEPINE 10,11-EPOXIDE IN PLASMA AND SALIVA FOLLOWING SOLID-PHASE SAMPLE EXTRACTION', JOURNAL OF CHROMATOGRAPHY, 380 347-356 (1986)
DOI10.1016/S0378-4347(00)83663-4Author URL
CitationsScopus - 14Web of Science - 19
Show 90 more journal articles

Conference (36 outputs)

YearCitationAltmetricsLink
2014Veysey M, Siow W, Niblett S, King K, Yates Z, Lucock M, 'Hepatic fibrosis in an elderly population', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Author URL
Co-authorsMartin Veysey, Katrina King, Zoe Yates
2014Veysey M, Siow W, Niblett S, King K, Yates Z, Lucock M, 'White cell counts and non-alcoholic fatty liver disease', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Author URL
Co-authorsZoe Yates, Martin Veysey
2013Veysey M, Siow W, Choi J-H, Martin C, Tang S, Yates ZR, Lucock M, 'A Bitter Taste Gene (P49a Variant of Tas2r38) Interacts With A1298c-MTHFR to Modify Risk for Adenomas in an Australian Population', GASTROENTEROLOGY, Orlando, FL (2013) [E3]
Author URL
Co-authorsZoe Yates, Martin Veysey
2013Choi J, Siow W, Yates Z, Lucock M, Veysey M, 'Influence of synthetic folic acid concentration on Caco-2 cell growth', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013) [E3]
Author URL
Co-authorsMartin Veysey, Zoe Yates
2013Siow W, Niblett S, King K, Yates Z, Hampe T, Lucock M, Veysey M, 'Prevalence of non-alcoholic fatty liver disease in an elderly Australian population', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013) [E3]
Author URL
Co-authorsZoe Yates, Katrina King, Martin Veysey
2013Siow W, Niblett S, King K, Yates Z, Martin C, Lucock M, Veysey M, 'A community-based study of dietary macro and micronutrients and the risk of colorectal cancer in an elderly Australian population', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013) [E3]
Author URL
Co-authorsZoe Yates, Martin Veysey, Katrina King
2011Choi J-H, Yates ZR, Boyd L, Veysey MJ, Lucock MD, 'Dietary folate vitamers as potential risk factors in the aetiology of adenomatous polyps', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authorsMartin Veysey, Zoe Yates
2011Yates ZR, Kho J, Choi J-H, Boyd L, Ng X, Skinner V, et al., 'C776G TCNII genotype influences the relationship between blood vitamin B12 and cellular folate', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authorsMartin Veysey, Zoe Yates
2011Naylor C, Lucock MD, Veysey MJ, Naumovski N, Boyd L, Dufficy L, et al., 'Folate nutritional genetics and degenerative disorders in the elderly with special reference to hypertension and depression', Australasian Medical Journal, Queenstown, NZ (2011) [E3]
Co-authorsZoe Yates, Martin Veysey, Paul Roach
2010Chang J, Lucock MD, Wai R, Boyd L, Ng X, Skinner VM, et al., 'Dietary folic acid, red cell folate and the risk of adenomatous polyps in an Australian population', Journal of Gastroenterology and Hepatology. Special Issue: Australian Gastroenterology Week 2010, Gold Coast, QLD (2010) [E3]
Co-authorsMartin Veysey, Zoe Yates, Paul Roach
2009Veysey MJ, Boyd L, Wai R, Ng X, Skinner V, Tang S, et al., 'Preliminary data to support a relationship between taste genetics, folate status, folate genes and the development of colonic adenomas: A novel nutrigenomic circuit', Gastro 2009 UEGW/WCOG: Scientific Programme & EACCME, London, UK (2009) [E3]
Co-authorsZoe Yates, Martin Veysey, Paul Roach
2009Boyd L, Lucock MD, Wai R, Ng X, Yates ZR, Skinner V, et al., 'Folate status: A recognised determinant of colorectal neoplasia may be modified by bitter taste perception and genetics', Proceedings of the Nutrition Society of Australia, Newcastle, NSW (2009) [E3]
Co-authorsZoe Yates, Martin Veysey, Paul Roach
2008Yates ZR, Lucock MD, 'Folate and the C677T-MTHFR variant: Impact on population health', Journal of Nutrigenetics and Nutrigenomics, Melbourne, VIC (2008) [E3]
DOI10.1159/000128589
Co-authorsZoe Yates
2008Ng X, Boyd L, Dufficy L, Naumovski N, Blades BL, Travers C, et al., 'Folate genes and risk for hypertension in an elderly population sample', 3rd Asia Pacific Nutrigenomics Conference: Conference Program & Information, Melbourne, VIC (2008) [E3]
Co-authorsZoe Yates, Paul Roach, Martin Veysey
2008Wai RKH, Boyd L, Ng X, King K, Skinner V, Roach PD, et al., 'Preliminary evidence that bitter taste perception can modify folate status: A recognised risk factor for colorectal neoplasia', Journal of Gastroenterology and Hepatology, Brisbane, QLD (2008) [E3]
Co-authorsPaul Roach, Zoe Yates, Martin Veysey
2008Boyd L, Wai RKH, Ng X, King K, Skinner V, Roach PD, et al., 'A preliminary study to examine whether common folate polymorphisms are risk factors for the development of adenomatous polyps', Journal of Gastroenterology and Hepatology, Brisbane, QLD (2008) [E3]
Co-authorsPaul Roach, Martin Veysey, Zoe Yates
2007Pengelly AR, Lucock MD, Roach PD, 'A method for assessing the variation in Flavonoid levels of Dodonaea viscosa subspecies Angustifolia, a traditional wound healing medicinal herb', 50 Years of the Phytochemical Society of Europe: Highlights in the Evolution of Phytochemistry. Abstract Book, Cambridge, U.K. (2007) [E3]
Co-authorsPaul Roach
2006Roach PD, Dufficy L, Naumovski N, Ng X, Blades BL, Travers C, et al., 'The association of dietary folate with serum and red cell folate is modulated by the G80A reduced folate carrier single nucloetide polymorphism in an elderly population sample', The Proceedings of the Nutrition Society of Australia, Sydney, NSW (2006) [E3]
Co-authorsMartin Veysey, Paul Roach
2006Blades BL, Naumovski N, Roach PD, Lucock MD, Travers C, Lewis PR, et al., 'Vitamin B12 is a better inverse correlate for homocysteine than folate in an elderly population sample', Atherosclerosis Supplements, Rome, Italy (2006) [E3]
Co-authorsMartin Veysey, Paul Roach
2006Roach PD, Naumovski N, Blades BL, Lucock MD, Travers C, Lewis PR, et al., 'Serum vitamin B12 is inversely related to blood pressure and anxiety in elderly women but not in elderly men', Atherosclerosis Supplements, Rome, Italy (2006) [E3]
Co-authorsPaul Roach, Martin Veysey
2006Naumovski N, Blades BL, Lucock MD, Travers C, Lewis PR, Sturm J, Veysey MJ, 'Serum vitamin B12 is inversely related to blood pressure and anxiety in women but not men in an elderly population sample', Heart Foundation Conference and Scientific Meeting, Sydney, NSW, Australia (2006) [E3]
Co-authorsMartin Veysey
2006Naumovski N, Roach PD, Blades BL, Lucock MD, Travers C, Lewis PR, et al., 'Homocysteine, vitamin B12 and folate in an elderly population sample', Heart Foundation Conference and Scientific Meeting, Sydney, NSW, Australia (2006) [E3]
Co-authorsPaul Roach, Martin Veysey
2006Roach PD, Dufficy L, Naumovski N, Ng X, Blades BL, Travers C, et al., 'The association of blood pressure with dietary folate in elderly females and its modulation by the G80A reduced folate carrier SNP', Program & Abstracts Australian Atherosclerosis Society, Couran Cove Island, Queensland (2006) [E3]
Co-authorsPaul Roach, Martin Veysey
2005Roach PD, Naumovski N, Dufficy L, Lucock MD, Blades BL, Lewis (Ext) PR, et al., 'Folate, viamin B12, plasma thiols and cognitive funciton in an elderly population sample', Asia Pacific Journal of Clinical Nutrition, Melbourne, Victoria (2005) [E3]
Co-authorsMartin Veysey, Paul Roach
2005Roach PD, Blades BL, Lucock MD, Naumovski N, Dufficy L, Lewis (Ext) PR, et al., 'Serum Vitamin B12 is Inversely Related to Blood Pressure in Women but not Men in an Elderly Population Sample', Proceedings of Annual Scientific Meeting 2005, Darwin, NT (2005) [E3]
Co-authorsMartin Veysey, Paul Roach
2004Novakovic P, Sohn KJ, Chiang EP, Dickhout J, Yates Z, Lucock M, et al., 'Effect of MTHFR C677T polymorphism on the intracellular methionine cycle and DNA methylation in colon cancer cells', FASEB JOURNAL, Washington, DC (2004)
Author URL
Co-authorsZoe Yates
2004Moskovitz DN, Sohn KJ, Smirnakis F, Novakovic P, Yates ZR, Lucock MD, et al., 'Effects of folylpolyglutamyl synthetase modulation on chemosensitivity of colon cancer cells to 5 fluorouracil and methotrexate', CDDW Abstracts, Canada (2004) [E3]
Co-authorsZoe Yates
2003Glanville T, Yates Z, Hopkins S, Walker JJ, Lucock M, Simpson N, 'Growth restriction is associated with fetal carriage of A66G methionine synthase reductase SNP', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, NEW ORLEANS, LOUISIANA (2003) [E1]
DOI10.1016/j.ajog.2003.10.618Author URL
CitationsWeb of Science - 1
2002Glanville T, Yates Z, Ovadia L, Walker JJ, Lucock M, Simpson N, 'Folate gene MTHFR C677T polymorphism and fetal growth restriction', Journal of Obstetrics and Gynaecology, 22(Supp1) S31-S32 (2002) [E1]
2002Lucock M, Yates Z, Goodall E, Achilli G, '12 Channel coulometric electrochemical detection for the identification of polyglutamate homology amongst cellular folates', Boston (2002) [E1]
2002Lucock M, Yates Z, Cade A, 'Gastro intestinal pH modulates facile interconvertion of native formylfolates during absorption', Boston (2002) [E1]
2002Yates Z, Lucock M, 'C677T MTHFR Genotype is a Risk Factor for Thromboembolism: Comparison of T Allele Frequency and Homocysteine Level between Female Thromboembolic and Non-Thromboembolic Vascualr Patients, NTD Mother and Matched NTD Controls', Boston (2002) [E1]
1997Lucock MD, Lumb C, Wild J, Oliver M, Daskalakis I, Schorah C, et al., 'Elevated homocysteine in subjects with a previous NTD pregnancy is associated with increased hexaglutamyl methylfolate consistent with impaired B-12 dependent methionine synthase activity.', CHEMISTRY AND BIOLOGY OF PTERIDINES AND FOLATES 1997, BERCHTESGADEN, GERMANY (1997)
Author URL
CitationsWeb of Science - 1
1997Lucock MD, Daskalakis IG, Lumb C, Oliver M, Wild J, Schorah C, Levene MI, 'One carbon metabolic parameters and NTD.', CHEMISTRY AND BIOLOGY OF PTERIDINES AND FOLATES 1997, BERCHTESGADEN, GERMANY (1997)
Author URL
1997Lucock MD, Lumb C, Wild J, Oliver M, Daskalakis I, Schorah CJ, et al., 'Methionine synthase activity is dependent upon intracellular methylfolate level in control but not NTD subjects where utilization of hexaglutamyl methylfolate is limiting for remethylation of homocysteine.', CHEMISTRY AND BIOLOGY OF PTERIDINES AND FOLATES 1997, BERCHTESGADEN, GERMANY (1997)
Author URL
CitationsWeb of Science - 2
1997Lucock MD, Lumb C, Wild J, Daskalakis I, Schorah CJ, Kendall R, Levene MI, 'Methyl group utilization versus production in NTD and control subjects: Influence of vitamin B-12', CHEMISTRY AND BIOLOGY OF PTERIDINES AND FOLATES 1997, BERCHTESGADEN, GERMANY (1997)
Author URL
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Grants and Funding

Summary

Number of grants15
Total funding$969,284

Click on a grant title below to expand the full details for that specific grant.


20121 grants / $24,500

Phase I and II detoxification genes; the correlation of epigenetic modifications with nutritional status, lifestyle factors, health and disease$24,500

Funding body: CSIRO - Energy Technology

Funding bodyCSIRO - Energy Technology
Project TeamAssociate Professor Mark Lucock, Associate Professor Martin Veysey, Doctor Zoe Yates, Miss Emma Beckett, Dr Konsta Duesing
SchemePostgraduate Research Scholarship
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200845
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20101 grants / $36,364

Is retirement village living good for health: Comparing the health of older adults living in retirement villages and the community$36,364

Funding body: Valhalla Village Pty Ltd

Funding bodyValhalla Village Pty Ltd
Project TeamAssociate Professor Martin Veysey, Dr Peter Lewis, Associate Professor Mark Lucock, Doctor Paul Roach, Dr David Kennedy
SchemeLinkage Projects Partner funding
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG1000936
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20091 grants / $61,281

The Association between Folate Nutritional Status and Folate Gene Polymorphisms in an Elderly Australian Population$61,281

Funding body: Central Coast Local Health District

Funding bodyCentral Coast Local Health District
Project TeamAssociate Professor Martin Veysey, Doctor Zoe Yates, Associate Professor Mark Lucock, Doctor Paul Roach
SchemeResearch Sponsorship Scholarship
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0190658
Type Of FundingOther Public Sector - State
Category2OPS
UONY

20084 grants / $660,923

Is retirement village living good for health: Comparing the health of older adults living in retirement villages and the community$390,173

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamAssociate Professor Martin Veysey, Dr Peter Lewis, Associate Professor Mark Lucock, Doctor Paul Roach, Dr David Kennedy
SchemeLinkage Projects
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188386
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Is retirement village living good for health: Comparing the health of older adults living in retirement villages and the community$170,750

Funding body: Central Coast Local Health District

Funding bodyCentral Coast Local Health District
Project TeamAssociate Professor Martin Veysey, Dr Peter Lewis, Associate Professor Mark Lucock, Doctor Paul Roach, Dr David Kennedy
SchemeLinkage Projects Partner funding
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188995
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Is retirement village living good for health: Comparing the health of older adults living in retirement villages and the community$85,000

Funding body: UnitingCare Ageing NSW.ACT

Funding bodyUnitingCare Ageing NSW.ACT
Project TeamAssociate Professor Martin Veysey, Dr Peter Lewis, Associate Professor Mark Lucock, Doctor Paul Roach, Dr David Kennedy
SchemeLinkage Projects Partner funding
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0189230
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Is retirement village living good for health: Comparing the health of older adults living in retirement villages and the community$15,000

Funding body: Urbis Pty Ltd

Funding bodyUrbis Pty Ltd
Project TeamAssociate Professor Martin Veysey, Dr Peter Lewis, Associate Professor Mark Lucock, Doctor Paul Roach, Dr David Kennedy
SchemeLinkage Projects Partner funding
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0189232
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20072 grants / $40,088

The role of folic acid nutritional genetics in common chronic degenerative disorders$29,424

Funding body: Central Coast Local Health District

Funding bodyCentral Coast Local Health District
Project TeamAssociate Professor Mark Lucock, Mrs Lyndell Boyd
SchemeResearch Sponsorship Scholarship
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187843
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Maternal probiotic treatment protects against colonic and immune dysfunctions induced by neonatal stress$10,664

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Deborah Hodgson, Doctor Michelle Adams, Associate Professor Mark Lucock
SchemePilot Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187857
Type Of FundingInternal
CategoryINTE
UONY

20053 grants / $50,044

2005 RIBG allocation$31,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Mark Lucock
SchemeResearch Infrastructure Block Grant (RIBG)
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185844
Type Of FundingInternal
CategoryINTE
UONY

Vitamin B12 and Autism$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Michelle Adams, Associate Professor Mark Lucock
SchemeProject Grant
RoleInvestigator
Funding Start2005
Funding Finish2005
GNoG0184636
Type Of FundingInternal
CategoryINTE
UONY

Central Coast Vascular Health in Retirement Village Residents Study, Phase 1$9,044

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Martin Veysey, Associate Professor Mark Lucock
SchemeProject Grant
RoleInvestigator
Funding Start2005
Funding Finish2005
GNoG0184680
Type Of FundingInternal
CategoryINTE
UONY

20042 grants / $86,084

PhD - Physio-chemical properties and genetic factors that influence folic acid bioavailability and metabolism: Implications in health and disease$66,084

Funding body: Central Coast Health Teaching & Research Unit

Funding bodyCentral Coast Health Teaching & Research Unit
Project TeamAssociate Professor Mark Lucock, Miss Xiaowei Ng
SchemePostgraduate Research Scholarship
RoleLead
Funding Start2004
Funding Finish2004
GNoG0184604
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Vitamin B12 and gene interactions in autism$20,000

Funding body: Hunter Children`s Research Foundation

Funding bodyHunter Children`s Research Foundation
Project TeamDoctor Michelle Adams, Associate Professor Mark Lucock, Conjoint Associate Professor John Stuart
SchemeResearch Grant
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0184142
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20031 grants / $10,000

B-vitamin nutrition and genetics in degenerative and development disorders: A study of nutrient-nutrient, nutrient-gene and gene-gene interactions$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Mark Lucock
SchemeNew Staff Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0183548
Type Of FundingInternal
CategoryINTE
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2014Vitamin D Status of Older People in Relation to Non-Communicable Disease
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2012The Association of MIRNA Profiles and DNA Methylation with Micronutrient Intake & Status
Food Science & Biotechnology, Faculty of Science and Information Technology
Principal Supervisor
2010Genotype-Phenotype Relationships Relevant to the Lifecycle with Special Reference to Vitamin Nutrition
Food Science & Biotechnology, Faculty of Science and Information Technology
Co-Supervisor
2007The role of folic acid nutritional genetics in common chronic degenerative disorders
Food Science & Biotechnology, University of Newcastle
Co-Supervisor
2004Physico-chemical Properties and Genetic Factors that influence the Bioavailability and Metabolism of Folic Acid: Implications in Health and Disease
Food Science & Biotechnology, University of Newcastle
Principal Supervisor
2003Investigation of Anti-inflammatory Properties in Dodonaea Species
Food Science & Biotechnology, University of Newcastle
Co-Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2014The Role of Folic Acid Related Nutritional Genetics in Common Chronic Degenerative Disorders
Food Science & Biotechnology, Faculty of Science and Information Technology
Principal Supervisor
2014In Vitro and In Vivo Approaches to the Examination of Folate-Related Nutritional Genetics in Health and Disease
Food Science & Biotechnology, Faculty of Science and Information Technology
Co-Supervisor
2009Physico-Chemical Properties and Genetic Factors That Influence the Bioavailability and Metabolism of Folic Acid: Implications in Health and Diseases
Food Science & Biotechnology, Faculty of Science and Information Technology
Principal Supervisor
2009Flavonoid Profile and Bioactivity of Dodonaea Viscosa (Australian Hop Bush) - An Indigenous Shrub
Food Science & Biotechnology, Faculty of Science and Information Technology
Co-Supervisor
2008The Effect of Temperature Management on the Quality of Broccoli and Table Grapes Exported from Australia
Food Science & Biotechnology, Faculty of Science and Information Technology
Co-Supervisor
2007Optimisation Of Polysaccharides from Echinacea Purpurea
Food Science & Biotechnology, Faculty of Science and Information Technology
Co-Supervisor
2006THE EFFECT OF NUTRITION AND GENETIC VARIANTS OF VITAMIN B12 METABOLISM ON BIOCHEMICAL AND CLINICAL PHENOTYPE IN AN ELDERLY POPULATION
Food Science & Biotechnology, University of Newcastle
Co-Supervisor
2006The effect of temperature on (-)-epigallochatechin gallate, the major catechin in green tea
Food Science & Biotechnology, University of Newcastle
Co-Supervisor
2005Does the G80A reduced folate carrier variant alter the cellular level of folate and as a consequence plasma homocysteine, and is this influenced by folate intake
Food Prcessing Technology, University of Newcastle
Co-Supervisor
2005Is cognitive function related to plasma thiol disposition in an elderly population
Food Science & Biotechnology, University of Newcastle
Co-Supervisor
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News

Health Check

Health check: antioxidants vs free radicals

October 9, 2013

Health Check: the untrue story of antioxidants vs free radicals

Associate Professor Mark Lucock

Position

Associate Professor
Human Molecular Nutrition
School of Environmental and Life Sciences
Faculty of Science and Information Technology

Focus area

Applied Sciences

Contact Details

Emailmark.lucock@newcastle.edu.au
Phone(02) 4348 4109
Fax(02) 4348 4145

Office

RoomE1.25
BuildingScience Offices
LocationOurimbah
10 Chittaway Road
Ourimbah, NSW 2258
Australia
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