Dr Katrina King

Research Academic

School of Medicine and Public Health

Career Summary

Biography

Dr Katrina King is a research academic with the School of Medicine and Public Health, University of Newcastle. She trained as a research scientist with particular expertise in amino acid biochemistry and chronic illness at the University of Newcastle and received her PhD in Biological Sciences in 1999. Since commencing with the Department of Medicine and Public Health, Katrina has become involved in a number of projects associated with colorectal cancer screening including an assessment of the effectiveness of community based faecal occult screening programs for colorectal cancer and an evaluation of the follow-up referral patterns, health care utilisation and clinical outcomes for patients with a positive faecal occult blood tests. She has also been involved in the design and conduct of the Retirement Health and Lifestyle Study, a large multidisciplinary research project conducted by the University of Newcastle in association with researchers from the Central Coast Local Health District Public Health Unit, Urbis Pty Ltd and Hunter Valley Research Foundation. The Retirement Health and Lifestyle study is an on-going cross-sectional study of how older people’s (>65 years of age) homes and neighbourhoods influence their health, well-being and lifestyle. Dr Katrina King’s current research interests include the investigation of factors that influence the health and lifestyle of older Australians, in particular, understanding the role of facility provision, built environment and social factors in improving health outcomes, and the development of preventative health strategies to promote healthy ageing.

Research Expertise
Dr Katrina King has been involved in clinical research for a number of years. Over this time she has developed considerable experience working with large multi-disciplinary and collaborative research projects investigating various aspects of human health and disease. She has also developed expertise in all areas of study management, including study administration, study design, the selection and development of research tools, and the management of staff, and the management and analysis of large multifactorial data sets. Throughout her career she has gained research expertise in the areas of chronic fatigue syndrome, colorectal cancer, cardiovascular disease, preventative and population health and the role of amino acids in disease pathophysiology.


Collaborations
Katrina has worked with several large, multi-disciplinary research teams and has formed collaborations with researchers from the: • School of Environmental and Life Sciences and School of Medicine and Public Health, University of Newcastle; • School of Population Health, University of Queensland; • School of Design, Queensland University of Technology; • Public Health Unit, Central Coast Local Health District; • Hunter Valley Research Foundation; • UnitingCare Ageing NSW.ACT; • Urbis Pty Ltd; and • Department of Health Promotion & Education and Department of Endocrinology, Royal North Shore Hospital.


Qualifications

  • PhD, University of Newcastle
  • Bachelor of Science, University of Newcastle
  • Bachelor of Science (Honours), University of Newcastle

Keywords

  • Built Environment
  • Cardiovascular Disease
  • Colorectal Cancer
  • Gerontology
  • Health
  • Physical Activity
  • Preventative Medicine

Fields of Research

Code Description Percentage
110101 Medical Biochemistry: Amino Acids and Metabolites 20
111712 Health Promotion 40
111716 Preventive Medicine 40

Professional Experience

UON Appointment

Title Organisation / Department
Research Academic University of Newcastle
School of Medicine and Public Health
Australia

Academic appointment

Dates Title Organisation / Department
1/10/2005 -  Research Academic University of Newcastle
School of Medicine and Public Health
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (4 outputs)

Year Citation Altmetrics Link
2016 Ferguson JJA, Veysey M, Lucock M, Niblett S, King K, MacDonald-Wicks L, Garg ML, 'Association between omega-3 index and blood lipids in older Australians', Journal of Nutritional Biochemistry, 27 233-240 (2016)

© 2015 Elsevier Inc.Management of hyperlipidaemia remains a cornerstone therapy for the prevention of cardiovascular disease (CVD). Dietary supplementation with n-3 polyunsaturat... [more]

© 2015 Elsevier Inc.Management of hyperlipidaemia remains a cornerstone therapy for the prevention of cardiovascular disease (CVD). Dietary supplementation with n-3 polyunsaturated fatty acid (PUFA) has been shown to modulate blood lipid profiles and reduce the risk of developing CVD. However, studies relating objective measures of long-term dietary n-3 PUFA intake and circulating lipid levels in older adults are limited. Thus, we aimed to determine whether there is an association between erythrocyte n-3 PUFA status (omega-3 index, O3I) and blood lipid profiles in older adults. A sample of adults aged 65-95 years who participated in the Retirement Health and Lifestyle Study was evaluated. Outcome measures included O3I (% eicosapentaenoic acid+% docosahexaenoic acid) and fasting blood lipid profiles [total cholesterol (TC), low-density lipoprotein (LDL)-cholesterol, high-density lipoprotein (HDL)-cholesterol and triglyceride (TG)]. Two hundred and seventy-six subjects were included in the analyses. The mean±SD age was 77.6±7.4 years, and 40.9% were males. O3I was significantly higher in females compared to males. O3I was inversely associated with plasma TG (P<.001) and TC/HDL-cholesterol ratio (P<.05), and positively associated with HDL-cholesterol (P<.05), in all subjects. Associations between O3I and TG were evident in both females (r=-0.250, P<.01) and males (r=-0.225, P<.05). In females only, the odds of being hypertriglyceridaemic were highest in those with lowest O3I (P=006). Trends for hypercholesterolaemia and elevated LDL risk were converse between males and females. Long-term n-3 PUFA status is associated with blood lipid profiles in older Australians. Our findings support the development and implementation of age-specific dietary strategies to reduce the risk of CVD via improving the O3I.

DOI 10.1016/j.jnutbio.2015.09.010
Co-authors Martin Veysey, Manohar Garg, Mark Lucock, Lesley Wicks
2015 Beckett EL, Martin C, Choi JH, King K, Niblett S, Boyd L, et al., 'Folate status, folate-related genes and serum miR-21 expression: Implications for miR-21 as a biomarker', BBA Clinical, 4 45-51 (2015) [C1]

© 2015.Background: Free circulating microRNA (miRNA) in serum may be valuable biomarkers for disease diagnosis and prognosis. miR-21, the archetypal oncogenic miRNA, has been pro... [more]

© 2015.Background: Free circulating microRNA (miRNA) in serum may be valuable biomarkers for disease diagnosis and prognosis. miR-21, the archetypal oncogenic miRNA, has been proposed as a biomarker for colorectal cancer and its benign precursor, adenomatous polyps. However, it is now becoming clear that circulating miRNA profiles may be sensitive to lifestyle and environmental influences. Dietary components involved in one-carbon metabolism are particularly well placed to modulate miRNA expression through an influence on DNA methylation pathways. Methods: We investigated the role of methyl group donors (folate, B12, cysteine, homocysteine), polymorphisms of the enzymes of one-carbon metabolism, and serum miR-21 expression in a primary case-control cohort (colonoscopy confirmed adenomatous colon polyps vs controls; n. =. 253) and a secondary cross-sectional cohort (over 65s; n. =. 649). The relationships between these parameters and serum miR-21 levels were assessed, stratified by gender. Conclusions: Serum miR-21 expression was related to occurrence of adenomatous polyps in females, but not males. Folate levels and MTHFR-C677T genotype was associated with miR-21 expression in both genders. Additionally, DHFR-19 del and MSR-A66G were associated with miR-21 expression in females and males, respectively. Stimulation with excess folate increased expression of miR-21 in colon cancer cell lines. General significance: This study demonstrates that serum miR-21 expression correlates with folate status and related genetic status. This may have consequences for the proposed use of miR-21 as a colorectal cancer biomarker.

DOI 10.1016/j.bbacli.2015.06.006
Citations Scopus - 1
Co-authors Zoe Yates, Mark Lucock, Martin Veysey
2007 Niblett SH, King KE, Dunstan RH, Clifton-Bligh P, Hoskin LA, Roberts TK, et al., 'Hematologic and urinary excretion anomalies in patients with chronic fatigue syndrome', Experimental Biology and Medicine, 232 1041-1049 (2007) [C1]
DOI 10.3181/0702-RM-44
Citations Scopus - 13Web of Science - 9
Co-authors Hugh Dunstan, Tony Rothkirch, Tim Roberts
2000 McGregor NR, Niblett SH, Bligh PC, Dunstan RH, Fulcher G, Hoskin L, et al., 'The biochemistry of chronic pain and fatigue', JOURNAL OF CHRONIC FATIGUE SYNDROME, 7, NO.1 3-21 (2000) [C1]
Citations Scopus - 5
Co-authors Tim Roberts, Hugh Dunstan
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Conference (11 outputs)

Year Citation Altmetrics Link
2015 Garg M, Abbott K, Veysey M, Lucock M, Niblett S, King K, Burrows T, 'Association Between Omega-3 Index and Type 2 Diabetes in Older Overweight/Obese People is Sex Dependent', FASEB JOURNAL (2015) [E3]
Co-authors Tracy Burrows, Manohar Garg, Mark Lucock, Martin Veysey
2015 Kheir AO, King K, Niblett S, Martin C, Beckett E, Yates Z, et al., 'The relationship between non-alcoholic fatty liver disease and homocysteine', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2015) [E3]
Co-authors Zoe Yates, Mark Lucock, Martin Veysey
2015 Siow W, Niblett S, King K, Yates Z, Lucock M, Veysey M, 'NAFLD fibrosis score predicts an increased risk of colorectal polyps', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2015) [E3]
Co-authors Martin Veysey, Zoe Yates, Mark Lucock
2015 Veysey M, King K, Niblett SH, Martin C, Beckett EL, Yates ZR, et al., 'Homocysteine Status Is a Predictor of Non-Alcoholic Fatty Liver Disease and Is Genotype Dependent', GASTROENTEROLOGY (2015) [E3]
Co-authors Mark Lucock, Zoe Yates, Martin Veysey
2014 Veysey M, Siow W, Niblett S, King K, Yates Z, Lucock M, 'Hepatic fibrosis in an elderly population', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2014) [E3]
Co-authors Zoe Yates, Mark Lucock, Martin Veysey
2013 Siow W, Niblett S, King K, Yates Z, Hampe T, Lucock M, Veysey M, 'Prevalence of non-alcoholic fatty liver disease in an elderly Australian population', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013) [E3]
Co-authors Mark Lucock, Martin Veysey, Zoe Yates
2013 Siow W, Niblett S, King K, Yates Z, Martin C, Lucock M, Veysey M, 'A community-based study of dietary macro and micronutrients and the risk of colorectal cancer in an elderly Australian population', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2013) [E3]
Co-authors Martin Veysey, Mark Lucock, Zoe Yates
2006 King K, Leijten E, Walsh P, Vigenser B, 'A Comparison of the Rotary Bowelscan and National Bowel Cancer Screening Pilot: Is the National Program Cost-Effective' (2006) [E3]
2002 McGregor N, De Becker P, Clifton-Bligh P, Stein E, Butt HL, De Meirleir K, et al., 'Evidence-based model of the pathogenic mechanism associated with symptom expression in ME/CFS', Proceedings of International Clinical and Scientific Meeting (2002) [E3]
Co-authors Hugh Dunstan, Tim Roberts
1998 McGregor N, Dunstan RH, Niblett S, King K, Butt HL, Taylor W, et al., 'Dental Amalgams and CFS', The Clinical and Scientific Basis of Chronic fatigue Syndrome: From Myth Towards Management. Program and Abstracts (1998) [E3]
1998 Niblett SH, Hoskin LA, Dunstan RH, Clifton-Bligh P, McGregor N, Roberts TK, et al., 'Alterations in Urinary Amino and Organic Acid Excretion in Patients with Chronic Fatigue Syndrome.', The Clinical and Scientific Basis of Chronic fatigue Syndrome: From Myth Towards Management. Program and Abstracts (1998) [E3]
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Grants and Funding

Summary

Number of grants 1
Total funding $364,000

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $364,000

Is retirement village living good for health: Comparing the health of older adults living in retirement villages and the community$364,000

Funding body: Central Coast Local Health District

Funding body Central Coast Local Health District
Project Team Associate Professor Martin Veysey, Doctor Katrina King, Doctor Suzanne Niblett
Scheme Research Grant
Role Investigator
Funding Start 2015
Funding Finish 2016
GNo G1401449
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y
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Dr Katrina King

Position

Research Academic
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Email katrina.king@newcastle.edu.au
Phone (02) 43656471

Office

Building Teaching and Research Unit
Location Gosford
Cnr Henry Parry Drive and Margin Street
Gosford, NSW 2250
Australia
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