Dr Roger Liang
School of Biomedical Sciences and Pharmacy (Pharmacy and Experimental Pharmacology)
- Phone:(02) 4985 4959
Dr Liang was trained as a pharmaceutical scientist and has since developed well-equipped research capabilities and leadership in the cross-disciplinary field of advanced drug delivery and nanomedicine. Dr. Liang completed his PhD in Pharmacy from the University of Queensland. His doctoral research theme was to develop nanoparticulate delivery systems for subunit vaccines, which spanned a range of fields including medicinal chemistry, pharmaceutical formulation, and immunology. Toward the end of his PhD, Dr Liang started to engage in research at the interface between polymer science and drug delivery and had gained hands-on experience in a variety of polymerisation and bioconjugation techniques. Upon completion of PhD, Dr Liang took up a postdoctoral position at UQ to investigate the biological interactions and toxicity of precisely engineered nanoparticles. This research had led to some key fundamental discoveries that resulted in several publications in the premium journals including ACS Nano, Nature Nanotechnology, Nanomedicines etc. During this time, Dr Liang was also a research teaching academic at School of Pharmacy and committed to teaching pharmacy undergraduates. After that, Dr Liang joined the Centre for Advanced Macromolecular Design in University of New South Wales, and his research was to develop a platform technology for the efficient delivery of albendazole towards better anti-cancer treatment. In 2011, Dr Liang accepted a lecturer position to establish drug delivery research group at the School of Biomedical Science and Pharmacy in University of Newcastle.
Dr Liang’s current research centres on advanced drug delivery and nanomedicine, which are at the interface of multidisciplinary fields including chemical & molecular engineering, materials science, chemistry, biotechnology and medicine. His research mainly involves developing novel biomaterials, utilizing self-assembly strategies to formulate biomaterials into desired nano-, micro- and macroscopic structures, and studying applications of these engineered structures for disease treatment and diagnosis.
I mainly teach into pharmaceutics and pharmacy practice within Master of Pharmacy program. In addition, I also deliver guest lectures into Bachelor of Biomedical Science program in the field of drug delivery.
- PhD, University of Queensland
- Drug delivery
- Pharmacy Practice
|Title||Organisation / Department|
|Lecturer||University of Newcastle
School of Biomedical Sciences and Pharmacy
For publications that are currently unpublished or in-press, details are shown in italics.
Journal article (18 outputs)
Jiang Y, Liang M, Svejkar D, Hart-Smith G, Lu H, Scarano W, Stenzel MH, 'Albumin-micelles via a one-pot technology platform for the delivery of drugs', Chemical Communications, 50 6394-6394 (2014) [C1]
Noorani L, Pourgholami MH, Liang M, Morris DL, Stenzel M, 'Albendazole loaded albumin nanoparticles for ovarian cancer therapy', European Journal of Nanomedicine, 6 227-236 (2014) [C1]
Albendazole (ABZ), a well-established antiparasitic drug, has been shown to suppress tumor growth in a number of preclinical models of cancer. However, the low solubility of ABZ l... [more]
Albendazole (ABZ), a well-established antiparasitic drug, has been shown to suppress tumor growth in a number of preclinical models of cancer. However, the low solubility of ABZ limits its use as a systemic anticancer agent. To enable systemic administration, we have formulated ABZ into albumin nanoparticles with a size range of 200-300 nm, which were cross-linked with glutaraldehyde to stabilize the nanoparticles and to introduce pH-responsive features. Drug release studies demonstrated that about 20% of ABZ was released at neutral pH within a week in comparison to 70% at slightly acidic condition (pH 5). Cellular uptake studies using ovarian cancer cells indicated that nanoparticles were internalized efficiently within 1 h of incubation. Further, cell proliferation results demonstrated that albumin nanoparticles alone showed no cytotoxicity to both normal and cancer cells. In contrast, the drug-loaded nanoparticles exhibited cellular toxicity and high killing efficacy to cancer cells compared to normal cells. Collectively, our results suggest that these albumin nanoparticles may hold great potentials as ABZ carriers for cancer therapy.
Deng ZJ, Liang M, Toth I, Monteiro M, Minchin RF, 'Plasma protein binding of positively and negatively charged polymer-coated gold nanoparticles elicits different biological responses', Nanotoxicology, 7 314-322 (2013) [C1]
|Show 15 more journal articles|
Conference (2 outputs)
Shargh VH, Hondermarck H, Liang M, 'MULTIFUNCTIONAL NANOMEDICINES BASED ON ALBUMIN FOR TARGETED BREAST CANCER THERAPY', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
|2012||Zhao Y, Liang M, Kim Y, Tan X, Zhang L, Stenzel MH, 'Development of core-crosslinked micelles for drug delivery system', Advanced Materials Research, Hong Kong (2012) [E1]|
Grants and Funding
|Number of grants||1|
Click on a grant title below to expand the full details for that specific grant.
20141 grants / $1,500
4th Annual World Congress of Nanoscience and Technology, Qingdao, P.R.China, 23 - 31 October 2014$1,500
Funding body: University of Newcastle - Faculty of Health and Medicine
|Funding body||University of Newcastle - Faculty of Health and Medicine|
|Project Team||Doctor Roger Liang|
|Type Of Funding||Internal|
|Commenced||Research Title / Program / Supervisor Type|
Multifunctional Nanomedicines Based on Albumin for Targeted Cancer Therapy
Pharmacy, Faculty of Health and Medicine
Dr Roger Liang
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
Pharmacy and Experimental Pharmacology
|Phone||(02) 4985 4959|
|Fax||(02) 4921 7903|
|Building||Medical Science Building|
Callaghan, NSW 2308