2023 |
Rostas JAP, Skelding KA, 'Calcium/Calmodulin-Stimulated Protein Kinase II (CaMKII): Different Functional Outcomes from Activation, Depending on the Cellular Microenvironment.', Cells, 12 401 (2023) [C1]
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Nova |
2021 |
Abraham WC, Geffen LB, McLachlan EM, Richards LJ, Rostas JAP, 'A brief history of the Australasian Neuroscience Society', JOURNAL OF THE HISTORY OF THE NEUROSCIENCES, 31 395-408 (2021)
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2017 |
Rostas JAP, Spratt NJ, Dickson PW, Skelding KA, 'The role of Ca
Studies in multiple experimental systems show that Ca2+-calmodulin stimulated protein kinase II (CaMKII) is a major mediator of ischaemia-induced cell death and suggest that CaMKI... [more]
Studies in multiple experimental systems show that Ca2+-calmodulin stimulated protein kinase II (CaMKII) is a major mediator of ischaemia-induced cell death and suggest that CaMKII would be a good target for neuroprotective therapies in acute treatment of stroke. However, as CaMKII regulates many cellular processes in many tissues any clinical treatment involving the inhibition of CaMKII would need to be able to specifically target the functions of ischaemia-activated CaMKII. In this review we summarise new developments in our understanding of the molecular mechanisms involved in ischaemia-induced CaMKII-mediated cell death that have identified ways in which such specificity of CaMKII inhibition after stroke could be achieved. We also review the mechanisms and phases of tissue damage in ischaemic stroke to identify where and when CaMKII-mediated mechanisms may be involved.
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Nova |
2017 |
Rostas JAP, Hoffman A, Murtha LA, Pepperall D, McLeod DD, Dickson PW, et al., 'Ischaemia- and excitotoxicity-induced CaMKII-Mediated neuronal cell death: The relative roles of CaMKII autophosphorylation at T286 and T253', Neurochemistry International, 104 6-10 (2017) [C1]
Ischaemia/excitotoxicity produces persistent activation of CaMKII (Ca2+-calmodulin stimulated protein kinase II) that initiates cell death. This study investigated the involvement... [more]
Ischaemia/excitotoxicity produces persistent activation of CaMKII (Ca2+-calmodulin stimulated protein kinase II) that initiates cell death. This study investigated the involvement of CaMKII phosphorylation at T286 and T253 in producing this persistent activation. In T286A-aCaMKII transgenic mice that lack the ability to phosphorylate aCaMKII at T286, transient occlusion of the middle cerebral artery for 90¿min resulted in no significant difference in infarct size compared to normal littermate controls. Overexpression of the phospho-mimic mutant T286D-aCaMKII in differentiated neuroblastoma cell lines did not enhance excitotoxicity-induced cell death compared to overexpression of wild type aCaMKII. By contrast, overexpression of the phospho-mimic mutant T253D-aCaMKII significantly enhanced excitotoxicity-induced cell death whereas overexpression of the phospho-null mutant T253V-aCaMKII produced no enhancement. These results indicate that T286 phosphorylation does not play a significant role in ischaemia/excitotoxicity induced CaMKII-mediated cell death and suggest that T253 phosphorylation is required to produce the persistent activation of CaMKII involved in ischaemia/excitotoxicity induced cell death.
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Nova |
2014 |
Skelding KA, Arellano JM, Powis DA, Rostas JA, 'Excitotoxic stimulation of brain microslices as an in vitro model of stroke.', J Vis Exp, e51291 (2014) [C1]
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Nova |
2014 |
Hoffman A, Carpenter H, Kahl R, Watt LF, Dickson PW, Rostas JAP, et al., 'Dephosphorylation of CaMKII at T253 controls the metaphase-anaphase transition', Cellular Signalling, 26 748-756 (2014) [C1]
Calcium/calmodulin-stimulated protein kinase II (CaMKII) is a multi-functional serine/threonine protein kinase that controls a range of cellular functions, including proliferation... [more]
Calcium/calmodulin-stimulated protein kinase II (CaMKII) is a multi-functional serine/threonine protein kinase that controls a range of cellular functions, including proliferation. The biological properties of CaMKII are regulated by multi-site phosphorylation and targeting via interactions with specific proteins. To investigate the role specific CaMKII phosphorylation sites play in controlling cell proliferation and cell cycle progression, we examined phosphorylation of CaMKII at two sites (T253 and T286) at various stages of the cell cycle, and also examined the effects of overexpression of wild-type (WT), T286D phosphomimic, T253D phosphomimic and T253V phosphonull forms of CaMKIIa in MDA-MB-231 breast cancer and SHSY5Y neuroblastoma cells on cellular proliferation and cell cycle progression. We demonstrate herein that whilst there is no change in total CaMKII expression or T286 phosphorylation throughout the cell cycle, a marked dephosphorylation of CaMKII at T253 occurs during the G2 and/or M phases. Additionally, we show by molecular inhibition, as well as pharmacological activation, that protein phosphatase 2A (PP2A) is the phosphatase responsible for this dephosphorylation. Furthermore, we show that inducible overexpression of WT, T286D and T253V forms of CaMKIIa in MDA-MB-231 and SHSY5Y cells increases cellular proliferation, with no alteration in cell cycle profiles. By contrast, overexpression of a T253D phosphomimic form of CaMKIIa significantly decreases proliferation, and cells accumulate in mitosis, specifically in metaphase. Taken together, these results strongly suggest that the dephosphorylation of CaMKII at T253 is involved in controlling the cell cycle, specifically the metaphase-anaphase transition. © 2014 Elsevier Inc.
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Nova |
2014 |
Abdul Majeed ABB, Pearsall E, Carpenter H, Brzozowski J, Dickson PW, Rostas JAP, Skelding KA, 'CaMKII Kinase Activity, Targeting and Control of Cellular Functions: Effect of Single and Double Phosphorylation of CaMKIIa', Calcium Signaling, 1 36-51 (2014) [C1]
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Nova |
2013 |
Skelding KA, Majeed ABA, Carpenter H, Dickson PW, Rostas JA, 'Can functional outcomes of CaMKII double phosphorylation be predicted from outcomes following single phosphorylation of CaMKII?', JOURNAL OF NEUROCHEMISTRY, 125 162-162 (2013) [E3]
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2012 |
Skelding KA, Dickson PW, Verrills NM, Rostas JA, 'Progression through mitosis can be controlled by dephosphorylation of CaMKII at T253', JOURNAL OF NEUROCHEMISTRY, 123 31-31 (2012) [E3]
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2012 |
Rostas JA, Skelding KA, Fluechter L, Dickson PW, Spratt NJ, 'CaMKII is Differentially Regulated in Striatum and Cortex', JOURNAL OF NEUROCHEMISTRY, 123 63-63 (2012) [E3]
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Nova |
2012 |
Majeed ABA, Rostas JAP, Carpenter H, Dickson PW, Skelding KA, 'Multi-site phosphorylation of CaMKII regulates CaMKII function co-operatively', JOURNAL OF NEUROCHEMISTRY, 123 116-116 (2012) [E3]
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Nova |
2012 |
Skelding KA, Spratt NJ, Fluechter L, Dickson PW, Rostas JA, 'alpha CaMKII is differentially regulated in brain regions that exhibit differing sensitivities to ischemia and excitotoxicity', Journal of Cerebral Blood Flow and Metabolism, 32 2181-2192 (2012) [C1]
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2011 |
Skelding KA, Rostas JA, Verrills NM, 'Controlling the cell cycle: The role of calcium/calmodulin-stimulated protein kinases I and II', Cell Cycle, 10 631-639 (2011) [C1]
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Nova |
2010 |
Atkinson RJ, Rostas JA, Hunter M, 'Changes in mid-to-late latency auditory evoked responses in the chicken during neural maturation', Developmental Psychobiology, 52 24-34 (2010) [C1]
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Nova |
2010 |
Skelding KA, Suzuki T, Gordon SL, Xue J, Verrills NM, Dickson PW, Rostas JA, 'Regulation of CaMKII by phospho-Thr253 or phospho-Thr286 sensitive targeting alters cellular function', Cellular Signalling, 22 759-769 (2010) [C1]
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Nova |
2009 |
Skelding KA, Liao X, Verrills NM, Fluechter L, Dickson PW, Rostas JA, 'CaMKII phosphorylation at T253 alters neuronal growth rates and morphology', Journal of Neurochemistry, 110, Suppl. 2 42 (2009) [E3]
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2009 |
Rostas JA, Skelding KA, Verrills NM, Suzuki PW, Dickson T, 'CaMKII binding partners vary with cell type and phosphorylation state', Journal of Neurochemistry, 110, Suppl. 2 40-41 (2009) [E3]
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2009 |
Rosso OA, Mendes ADS, Rostas JA, Hunter M, Moscato PA, 'Distinguishing childhood absence epilepsy patients from controls by the analysis of their background brain electrical activity', Journal of Neuroscience Methods, 177 461-468 (2009) [C1]
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Nova |
2009 |
Rosso OA, Mendes ADS, Berretta RE, Rostas JA, Hunter M, Moscato PA, 'Distinguishing childhood absence epilepsy patients from controls by the analysis of their background brain electrical activity (II): A combinatorial optimization approach for electrode selection', Journal of Neuroscience Methods, 181 257-267 (2009) [C1]
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Nova |
2009 |
Skelding KA, Rostas JA, 'Regulation of CaMKII in vivo: The importance of targeting and the intracellular microenvironment', Neurochemical Research, 34 1792-1804 (2009) [C1]
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Nova |
2008 |
Gurd JW, Rawof S, Zhen Huo J, Dykstra C, Bissoon N, Teves L, et al., 'Ischemia and status epilepitcus result in enhanced phosphorylation of calcium and calmodulin-stimulated protein kinase II on threonine 253', Brain Research, 1218 158-165 (2008) [C1]
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Nova |
2008 |
Atkinson RJ, Migues PV, Hunter M, Rostas JA, 'Molecular changes in the intermediate medial mesopallium after a one trial avoidance learning in immature and mature chickens', Journal of Neurochemistry, 104 891-902 (2008) [C1]
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Nova |
2008 |
Skelding KA, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Development of a novel method for the identification of CaMKII binding proteins', Journal of Neurochemistry, 106 51 (2008) [E3]
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2008 |
Atkinson RJ, Migues PV, Cammarota M, Kavanagh JM, Hunter M, Rostas JA, 'Biochemical, behavioural and electrophysiological investigations of brain maturation in chickens', Brain Research Bulletin, 76 217-223 (2008) [C1]
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Nova |
2008 |
Gibbs ME, Gibbs C, Csillag A, Matsushima T, Rogers L, Rostas JA, 'Brain mechanisms, cognition and behaviour in birds', Brain Research Bulletin, 76 167-169 (2008) [C3]
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Nova |
2007 |
Migues PV, Cammarota MP, Kavanagh J, Atkinson RJ, Powis DA, Rostas JA, 'Maturational changes in the subunit composition of AMPA receptors and the functional consequences of their activation in chicken forebrain', Developmental Neuroscience, 29 232-240 (2007) [C1]
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2006 |
Sim AT, Herd LM, Proctor DT, Baldwin ML, Meunier FA, Rostas JA, 'High throughput analysis of endogenous glutamate release using a fluorescence plate reader', Journal of Neuroscience Methods, 153 43-47 (2006) [C1]
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2006 |
Baldwin ML, Cammarota MP, Sim AT, Rostas JA, 'Src family tyrosine kinases differentially modulate exocytosis from rat brain nerve terminals', Neurochemistry International, 49 80-86 (2006) [C1]
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2006 |
Migues PV, Lehmann IT, Fluechter L, Cammarota MP, Gurd JW, Sim AT, et al., 'Phosphorylation of CaMKII at Thr253 occurs in vivo and enhances binding to isolated postsynaptic densities', Journal of Neurochemistry, 98 289-299 (2006) [C1]
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Nova |
2005 |
Rosso OA, Hyslop WA, Gerlach RH, Smith RL, Rostas JA, Hunter M, 'Quantitative EEG analysis of the maturational changes associated with childhood absence epilepsy', Physica A -Statistical Mechanics and Its Applications, 356 184-189 (2005) [C1]
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2005 |
Hunter M, Smith RLL, Hyslop W, Rosso OA, Gerlach R, Rostas JAP, et al., 'The Australian EEG database', CLINICAL EEG AND NEUROSCIENCE, 36 76-81 (2005) [C2]
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2004 |
Xue J, Tsang C, Gai W-P, Malladi C, Trimble W, Rostas JA, Robinson P, 'Septin 3 (G-septin) is a developmentally regulated phosphoprotein enriched in presynaptic nerve terminals', Journal of Neurochemistry, 91(3) 579-590 (2004) [C1]
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Nova |
2004 |
Xue J, Milburn P, Hanna B, Graham M, Rostas JA, Robinson P, 'Phosphorylation of septin 3 on Ser-91 by cGMP-dependent protein kinase-I in nerve terminals', Biochem J, 381 753-760 (2004) [C1]
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2004 |
Lengyel I, Voss K, Cammarota MP, Bradshaw K, Brent VA, Murphy KPSJ, et al., 'Autonomous activity of CaMKII is only transiently increased following the induction of long-term potentiation in the rat hippocampus', European Journal of Neuroscience, 20 3063-3072 (2004) [C1]
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Nova |
2003 |
Hunter M, Rostas JA, Hyslop WA, 'The John Hunter Hospital EEG database project', Australian Journal of Psychology, 55 104 (2003) [C3]
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2003 |
Baldwin ML, Rostas JA, Sim AT, 'Two modes of excytosis from synaptosomes are differentially regulated by protein phosphatase types 2A and 2B', Journal of Neurochemistry, 85 1190-1199 (2003) [C1]
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Nova |
2003 |
Cammarota MP, Bevilaqua L, Rostas JA, Dunkley PR, 'Histamine activates tyrosine hydroxylase in bovine adrenal chromaffin cells through a pathway that involves ERK1/2 but not p38 or JNK', Journal of Neurochemistry, 84 453-458 (2003) [C1]
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2003 |
Sim AT, Baldwin ML, Rostas JA, Holst J, Ludowyke RI, 'The role of serine/threonine protein phosphatases in exocytosis', Biochemical Journal, 373 641-659 (2003) [C1]
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2003 |
Atkinson RJ, Bevilaqua L, Rostas JA, Hunter M, 'Discriminative taste aversion learning: A learning task for older chickens', Neurobiology of Learning and Memory, 79 25-31 (2003)
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2001 |
Lengyel I, Voss K, Brent V, Cammarota M, Murphy K, Rostas JAP, Bliss TVP, 'Activation and autophosphorylation of CaMPK-II under conditions that do or do not induce LTP', JOURNAL OF NEUROCHEMISTRY, 78 13-13 (2001) |
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2001 |
Lengyel I, Cammarota MP, Brent VA, Rostas JA, 'Autonomous activity and autophosphorylation of CAMPK-II in rat hippocampal slices: effects of tissue preparation', Journal of Neurochemistry, 76 149-154 (2001) [C1]
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Nova |
2001 |
Cammarota MP, Bevilaqua L, Dunkley PR, Rostas JA, 'Angiotensin II Promotes the Phosphorylation of Cyclic AMP-Responsive Element Binding Protein (CREB) at Ser133 Through an ERK1/2-Dependent Mechanism', Journal of Neurochemistry, 79 1122-1128 (2001) [C1]
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2001 |
Lengyel I, Nairn AC, McCluskey A, Toth G, Penke B, Rostas JAP, 'Auto-inhibition of Ca2+/calmodulin-dependent protein kinase II by its ATP-binding domain', Journal of Neurochemistry, 76 1066-1072 (2001) [C1]
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2001 |
Cammarota MP, Bevilaqua L, Dunkley PR, Rostas JA, 'Angiotensin II Promotes a Rapid and Reversible Increase in SRC-Tyrosine Kinase Activity in Bovine Adrenal Chromaffin Cells: Effect on MAPK Pathways', Proceedings of the Australian Neuroscience Society, 12 197 (2001) [C3]
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2001 |
Cammarota MP, Bevilaqua L, Dunkley PR, Rostas JA, 'Angiotensin II Promotes a Src and ERK 1/2 Dependent Increase in SER133-CREB Phosphorylation', Journal of Neurochemistry, 78 Supl. 1 143 (2001) [C3]
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2000 |
Hunter M, Battilana M, Bragg T, Rostas J, 'EEG as a measure of developmental changes in the chicken brain', Developmental Psychobiology, 36 23-28 (2000) [C1]
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2000 |
Lengyel I, Fieuw-Makaroff S, Hall AL, Sim AT, Rostas JA, Dunkley PR, 'Modulation of the Phosphorylation and Activity of Calcium/Calmodulin-Dependent Protein Kinase II by Zinc', Journal of Neurochemistry, 75 No. 2 594-605 (2000) [C1]
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Nova |
2000 |
Margrie TW, Rostas JA, Sah P, 'Inhibition of transmitter release and long-term depression in the avian hippocampus', Neuroscience Letters, 284 17-20 (2000) [C1]
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2000 |
Xue J, Wang X, Malladi CS, Kinoshita M, Milburn PJ, Lengyel I, et al., 'Phosphorylatin of a new brain-specific septin, G-Septin, by cyclic-GMP dependent protein kinase', Biological Chemistry, 275 10047-10056 (2000) [C1]
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1999 |
Lengyel I, Hall AL, Fieuw-Makaroff S, Sim ATR, Rostas JAP, Dunkley PR, 'Characterization of the zinc-dependent autophosphorylation sites on calcium/calmodulin-dependent protein kinase II', JOURNAL OF NEUROCHEMISTRY, 73 S33-S33 (1999)
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1999 |
Lengyel I, Brent V, Rostas JAP, 'Autonomous CaMPK-II activity in rat hippocapal slices: Effects of tissue handling', JOURNAL OF NEUROCHEMISTRY, 73 S36-S36 (1999) |
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1999 |
Rostas JAP, Sievert AD, McCoy K, Lengyel I, 'Mossy fibre-like synapses in chicken hippocampus', JOURNAL OF NEUROCHEMISTRY, 73 S40-S40 (1999) |
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1999 |
Lengyel I, Olson LG, Nichol K, Brain K, Wang X, Robinson PJ, et al., 'Phosphorylation of proteins in chick ciliary ganglion under conditions that induce long-lasting changes in synaptic transmission: phosphoprotein targets for nitric oxide action', Neuroscience, 90 No. 2 607-619 (1999) [C1]
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1998 |
Rostas JAP, 'Nitric oxide responsive protein phosphorylation in neuronal tissue', JOURNAL OF NEUROCHEMISTRY, 70 S4-S4 (1998) |
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1998 |
Capon RJ, Rooney F, Murray LM, Collins E, Sim AT, Rostas JA, et al., 'Dragmacidins: New protein phosphatase inhibitors from a Southern Australian deep-water marine sponge Spongosorites sp', Journal of Natural Products, 61 660-662 (1998) [C1]
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1998 |
Wang X, Rostas JA, 'Protein phosphorylation in fast and slow chicken skeletal muscles: Effect of denervation', Muscle and Nerve, 21 504-513 (1998) [C1]
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1998 |
Margrie TW, Rostas JA, Sah P, 'Presynaptic long-term depression at a central glutamatergic synapse: a role for CaMKII', Nature Neuroscience, 1(5) 378-383 (1998) [C1]
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1998 |
Lengyel I, Nichol KA, Bennett MR, Heath JW, Little GJ, Rostas JA, 'Alpha and beta subunits of CaM-kinase II are localized in different neurons in chick ciliary ganglion', NeuroReport, 9(12) 2753-2755 (1998) [C1]
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1998 |
Sim AT, Collins E, Mudge LM, Rostas JA, 'Developmental regulation of protein phosphatase types 1 and 2A in post-hatch chicken brain', Neurochemical Research, 23(4) 487-491 (1998) [C1]
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1998 |
Margrie TW, Rostas JA, Sah P, 'Long-term potentiation of synaptic transmission in the avian hippocampus', The Journal of Neuroscience, 18(4) 1207-1216 (1998) [C1]
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1997 |
Sansom AJ, Brent VA, Jarvie PE, Darlington CL, Smith PF, Laverty R, Rostas JAP, 'In vitro phosphorylation of medial vestibular nucleus and prepositus hypoglossi proteins during behavioural recovery from unilateral vestibular deafferentation in the guinea pig', BRAIN RESEARCH, 778 166-177 (1997)
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1997 |
Margrie TW, Rostas JAP, 'Subcellular translocation of Ca2+(calmodulin-dependent protein kinase II: Fact or artifact?', JOURNAL OF NEUROCHEMISTRY, 69 435-436 (1997)
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1997 |
Margrie TW, Rostas JAP, Sah P, 'NMDA receptor independent long-term potentiation in the avian hippocampus', JOURNAL OF NEUROCHEMISTRY, 69 S66-S66 (1997) |
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1997 |
Lengyel I, Olesen L, Wang X, Nichol KA, Bennett MR, Rostas PJ, Rostas JAP, 'Nitric oxide responsive phosphoproteins (NORPs) in chicken ciliary ganglion', JOURNAL OF NEUROCHEMISTRY, 69 S187-S187 (1997) |
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1997 |
Sansom AJ, Brent VA, Jarvie PE, Darlington CL, Smith CL, Laverty R, Rostas JAP, 'In vitro phosphorylation of medial vestibular nucleus and prepositus hypoglossi proteins during behavioural recovery from unilateral vestibular deafferentation in the guinea pig', JOURNAL OF NEUROCHEMISTRY, 69 S208-S208 (1997) |
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1997 |
Margrie TW, Rostas JAP, Suzuki T, 'Subcellular translocation of Ca
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1996 |
Wang X, Rostas JAP, 'Effect of hypothyroidism on the subcellular distribution of Ca2+ calmodulin-stimulated protein kinase II in chicken brain during posthatch development', JOURNAL OF NEUROCHEMISTRY, 66 1625-1632 (1996)
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1996 |
Rostas JAP, Brent VA, Voss K, Errington ML, Bliss TVP, Gurd JW, 'Enhanced tyrosine phosphorylation of the 2B subunit of the N-methyl-D-aspartate receptor in long-term potentiation', PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 93 10452-10456 (1996)
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1996 |
Lengyel I, Nichol KA, Sim ATR, Bennett MR, Dunkley PR, Rostas JAP, 'Characterization of protein kinase and phosphatase systems in chick ciliary ganglion', NEUROSCIENCE, 70 577-588 (1996)
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1995 |
KAVANAGH JM, BUNN SJ, BOYD TL, ROSTAS JAP, 'DEVELOPMENTAL-CHANGES IN GLUTAMATE-RECEPTOR STIMULATED INOSITOL PHOSPHOLIPID-METABOLISM AND CA-45(2+)-ACCUMULATION IN POSTHATCH CHICKEN FOREBRAIN', NEUROSCIENCE LETTERS, 194 161-164 (1995)
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1995 |
HEATH JW, LITTLE GJ, ROBINSON CS, SCHULMAN H, ROSTAS JAP, 'LM AND EM IMMUNOLOCALIZATION OF ALPHA-CAMPK-II AND BETA-CAMPK-II', JOURNAL OF NEUROCHEMISTRY, 65 S22-S22 (1995) |
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1995 |
SIM ATR, RATCLIFFE E, ROSTAS JAP, 'DIFFERENTIAL REGULATION OF MEMBRANE-BOUND PROTEIN PHOSPHATASES IN BRAIN', JOURNAL OF NEUROCHEMISTRY, 65 S93-S93 (1995) |
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1994 |
SIM ATR, RATCLIFFE E, MUMBY MC, VILLAMORUZZI E, ROSTAS JAP, 'DIFFERENTIAL ACTIVITIES OF PROTEIN PHOSPHATASE TYPE-1 AND TYPE-2A IN CYTOSOLIC AND PARTICULATE FRACTIONS FROM RAT FOREBRAIN', JOURNAL OF NEUROCHEMISTRY, 62 1552-1559 (1994) [C1]
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1994 |
SIM ATR, RATCLIFFE E, ROSTAS JAP, 'SELECTIVE REGULATION OF PROTEIN PHOSPHATASE-I DURING DEVELOPMENT IN CHICKEN FOREBRAIN AND CEREBELLUM', JOURNAL OF NEUROCHEMISTRY, 63 S73-S73 (1994) |
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1994 |
MARTIN H, ROSTAS J, PATEL Y, AITKEN A, 'SUBCELLULAR-LOCALIZATION OF 14-3-3-ISOFORMS IN RAT-BRAIN USING SPECIFIC ANTIBODIES', JOURNAL OF NEUROCHEMISTRY, 63 2259-2265 (1994)
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1993 |
MURRAY L, SIM ATR, ROSTAS JAP, CAPON RJ, 'ISOPALINURIN - A MILD PROTEIN PHOSPHATASE INHIBITOR FROM A SOUTHERN AUSTRALIAN MARINE SPONGE, DYSIDEA SP', AUSTRALIAN JOURNAL OF CHEMISTRY, 46 1291-1294 (1993)
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1993 |
MURRAY L, SIM ATR, ROSTAS JAP, CAPON RJ, 'ISOPALINURIN - A MILD PROTEIN PHOSPHATASE INHIBITOR FROM A SOUTHERN AUSTRALIAN MARINE SPONGE, DYSIDEA SP (VOL 46, PG 1291-1294, 1993)', AUSTRALIAN JOURNAL OF CHEMISTRY, 46 1824-1824 (1993)
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1993 |
CAPON RJ, ELSBURY K, BUTLER MS, LU CC, HOOPER JNA, ROSTAS JAP, et al., 'EXTRAORDINARY LEVELS OF CADMIUM AND ZINC IN A MARINE SPONGE, TEDANIA-CHARCOTI TOPSENT - INORGANIC CHEMICAL DEFENSE AGENTS', EXPERIENTIA, 49 263-264 (1993)
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1993 |
SHAHIN S, BARTLETT PF, MILLAR TJ, MCLENNAN I, ROSTAS JAP, 'DISTRIBUTION OF THE SLOW CARDIAC ISOFORM OF SKELETAL-MUSCLE CA2+-ATPASE IN DEVELOPING AND MATURE TISSUES OF CHICKENS DETERMINED USING A MONOCLONAL-ANTIBODY', JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 41 215-224 (1993)
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1993 |
KAVANAGH JM, BOYD TL, BUNN SJ, ROSTAS JAP, 'QUISQUALATE RECEPTOR FUNCTION IN CHICKEN FOREBRAIN', JOURNAL OF NEUROCHEMISTRY, 61 S16-S16 (1993) |
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1993 |
SIM ATR, RATCLIFFE E, DUNKLEY PR, ROSTAS JAP, 'MEMBRANE-BOUND FORMS OF PROTEIN PHOSPHATASE TYPE-1 AND TYPE-2A HAVE LOWER ACTIVITY THAN CYTOSOLIC FORMS IN BRAIN', JOURNAL OF NEUROCHEMISTRY, 61 S136-S136 (1993)
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1993 |
WANG X, ROSTAS JAP, 'MATURATION CHANGES IN CAM-PKII IN CHICKEN CEREBELLUM', JOURNAL OF NEUROCHEMISTRY, 61 S219-S219 (1993) |
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1993 |
LENGYEL I, NICHOL KA, BENNETT MR, ROSTAS JAP, DUNKLEY PR, 'PROTEIN-PHOSPHORYLATION IN CHICK CILIARY GANGLION', JOURNAL OF NEUROCHEMISTRY, 61 S221-S221 (1993)
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1993 |
KAVANAGH JM, ROSTAS JAP, 'AMPA RECEPTOR FUNCTION IN CHICKEN FOREBRAIN', JOURNAL OF NEUROCHEMISTRY, 61 S269-S269 (1993) |
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1993 |
SIM ATR, LLOYD HGE, JARVIE PE, MORRISON M, ROSTAS JAP, DUNKLEY PR, 'SYNAPTOSOMAL AMINO-ACID RELEASE - EFFECT OF INHIBITING PROTEIN PHOSPHATASES WITH OKADAIC ACID', NEUROSCIENCE LETTERS, 160 181-184 (1993)
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1992 |
ROSTAS JAP, DUNKLEY PR, 'MULTIPLE FORMS AND DISTRIBUTION OF CALCIUM/CALMODULIN-STIMULATED PROTEIN KINASE-II IN BRAIN', JOURNAL OF NEUROCHEMISTRY, 59 1191-1202 (1992)
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1992 |
HEATH JW, GLENFIELD PJ, ROSTAS JAP, 'STRUCTURAL MATURATION OF SYNAPSES IN THE RAT SUPERIOR CERVICAL-GANGLION CONTINUES BEYOND 4 WEEKS OF AGE', NEUROSCIENCE LETTERS, 142 17-21 (1992)
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1992 |
KAVANAGH JM, POWIS DA, DODD PR, ROSTAS JAP, 'NMDA RECEPTOR FUNCTION IN CHICKEN FOREBRAIN DURING MATURATION', MOLECULAR NEUROPHARMACOLOGY, 2 193-195 (1992)
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1991 |
WEINBERGER RP, ROSTAS JAP, 'EFFECT OF ZINC ON CALMODULIN-STIMULATED PROTEIN KINASE-II AND PROTEIN-PHOSPHORYLATION IN RAT CEREBRAL-CORTEX', JOURNAL OF NEUROCHEMISTRY, 57 605-614 (1991)
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1991 |
SIM ATR, DUNKLEY PR, JARVIE PE, ROSTAS JAP, 'MODULATION OF SYNAPTOSOMAL PROTEIN-PHOSPHORYLATION DEPHOSPHORYLATION BY CALCIUM IS ANTAGONIZED BY INHIBITION OF PROTEIN PHOSPHATASES WITH OKADAIC ACID', NEUROSCIENCE LETTERS, 126 203-206 (1991)
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1991 |
KAVANAGH JM, DODD PR, ROSTAS JAP, '[H-3] MK-801 BINDING IN IMMATURE AND MATURE CHICKEN FOREBRAIN', NEUROSCIENCE LETTERS, 134 83-87 (1991)
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1991 |
Kavanagh JM, Dodd PR, Rostas JAP, '[
Previous studies have shown that the rate of calcium uptake stimulated by N-methyl-d-aspartate (NMDA) increased during the maturation phase of synapse development in chicken foreb... [more]
Previous studies have shown that the rate of calcium uptake stimulated by N-methyl-d-aspartate (NMDA) increased during the maturation phase of synapse development in chicken forebrain. To investigate whether this change in function is due to a change in the properties of NMDA receptor associated ion channels, we measured the binding of [3H]MK-801 (a ligand which binds to the NMDA receptor associated ion channel) to membranes from immature and mature chicken brain. The binding properties of MK-801 in chicken brain were similar to those in mammalian brain. There was no significant difference in any of the binding parameters measured at the two ages, i.e. KD, Bmax and optimal glutamate concentration for and maximal enhancement by glutamate of MK-801 binding. These results suggest that there is no change in the NMDA operated ion-channels during maturation. Thus the maturational change in NMDA receptor function could be due to: a change in the agonist portion of the NMDA receptor, a change in the regulation of the receptor/ionophore complex, perhaps by the postsynaptic density whose structure and composition changes during the same period, or a change in the number of voltage-sensitive calcium channels recruited as a result of NMDA receptor activation. © 1991.
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1991 |
JEITNER TM, JARVIE PE, COSTA M, ROSTAS JAP, DUNKLEY PR, 'PROTEIN-PHOSPHORYLATION IN GUINEA-PIG MYENTERIC GANGLIA AND BRAIN - PRESENCE OF CALMODULIN KINASE-II, PROTEIN-KINASE-C AND CYCLIC-AMP KINASE AND CHARACTERIZATION OF MAJOR PHOSPHOPROTEINS', NEUROSCIENCE, 40 555-569 (1991)
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1991 |
KOSZKA C, BRENT VA, ROSTAS JAP, 'DEVELOPMENTAL-CHANGES IN PHOSPHORYLATION OF MAP-2 AND SYNAPSIN-I IN CYTOSOL AND TAXOL POLYMERIZED MICROTUBULES FROM CHICKEN BRAIN', NEUROCHEMICAL RESEARCH, 16 637-644 (1991)
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1991 |
ROSTAS JAP, KAVANAGH JM, DODD PR, HEATH JW, POWIS DA, 'MECHANISMS OF SYNAPTIC PLASTICITY - CHANGES IN POSTSYNAPTIC DENSITIES AND GLUTAMATE RECEPTORS IN CHICKEN FOREBRAIN DURING MATURATION', MOLECULAR NEUROBIOLOGY, 5 203-216 (1991)
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1990 |
SHAHIN S, JEFFREY PL, ROSTAS JAP, 'THY-1-LIKE IMMUNOREACTIVITY IN DEVELOPING CHICKEN SKELETAL-MUSCLE - IDENTIFICATION OF A CROSS-REACTIVE SLOW-FIBER SPECIFIC MOLECULE THAT IS NOT THY-1', JOURNAL OF NEUROSCIENCE RESEARCH, 26 45-54 (1990)
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1990 |
Wang X, Rostas JA, 'Development of Ca2(+)-calmodulin activated protein kinase II and cAMP activated protein kinase in the central nervous system', Sheng li ke xue jin zhan [Progress in physiology], 21 58-60 (1990) |
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1990 |
WEBB GR, REDMAN S, HENNRIKUS D, ROSTAS JAP, SANSONFISHER RW, 'THE PREVALENCE AND SOCIODEMOGRAPHIC CORRELATES OF HIGH-RISK AND PROBLEM DRINKING AT AN INDUSTRIAL WORKSITE', BRITISH JOURNAL OF ADDICTION, 85 495-507 (1990)
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1989 |
SHAHIN S, LASHER RS, MILLAR TJ, ROSTAS JAP, 'A MONOCLONAL-ANTIBODY AGAINST THE SLOW ISOFORM OF SKELETAL-MUSCLE CA-2+-ATPASE SELECTIVELY STAINS A SUBPOPULATION OF NEURONS IN THE CENTRAL NERVOUS-SYSTEM', NEUROSCIENCE LETTERS, 106 163-168 (1989)
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1989 |
ROSTAS JAP, BRENT VA, SECCOMBE M, WEINBERGER RP, DUNKLEY PR, 'PURIFICATION AND CHARACTERIZATION OF CALMODULIN-STIMULATED PROTEIN KINASE-II FROM 2-DAY AND ADULT CHICKEN FOREBRAIN', JOURNAL OF MOLECULAR NEUROSCIENCE, 1 93-104 (1989)
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1989 |
Rostas JAP, Brent VA, Seccombe M, Weinberger RP, Dunkley PR, 'Purification and characterization of calmodulin-stimulated protein kinase II from two-day and adult chicken forebrain', Journal of Molecular Neuroscience, 1 93-104 (1989)
Soluble calmodulin-stimulated protein kinase II has been purified from 2-day and adult chicken forebrain. At both ages the holoenzyme eluted from a Superose-6B column with an appa... [more]
Soluble calmodulin-stimulated protein kinase II has been purified from 2-day and adult chicken forebrain. At both ages the holoenzyme eluted from a Superose-6B column with an apparent molecular weight of approximately 700,000 daltons and contained three subunits. The subunits were found to be the counterparts of the alpha, beta, and beta' subunits of the enzyme purified from adult rat brain in that they had one-dimensional phosphopeptide maps that were indistinguishable from those of the corresponding subunit in the rat enzyme and they migrated in SDS-polyacrylamide gels with the same apparent molecular weights. However, the doublet formed by the beta subunit was much more clearly resolved in the chicken enzyme and the beta' subunit, which was much more abundant in the adult chicken than in the adult rat, was also found to be a doublet. The ratio of the concentrations of the alpha and beta subunits changed during development. By autoradiography following autophosphorylation, the alpha:beta ratios of the 2-day and adult enzymes were 0.89 ± 0.07 and 1.92 ± 0.26, respectively; by silver staining the alpha:beta ratios were 0.95 ± 0.11 and 1.85 ± 0.17, respectively. The concentration of the beta' subunit was equal to that of the beta subunit at both ages. Autophosphorylation produced a decrease in the electrophoretic mobility of the alpha and beta subunits in SDS-polyacrylamide gels and a marked decrease in the calcium dependence of the substrate phosphorylation activity of the enzyme at both ages. The purified enzyme from chicken brain appeared to be more stable under standard in vitro assay conditions than the rat enzyme, and this was particularly so for the enzyme from 2-day forebrain. © 1989 Humana Press Inc.
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1988 |
DUNKLEY PR, HEATH JW, HARRISON SM, JARVIE PE, GLENFIELD PJ, ROSTAS JAP, 'A RAPID PERCOLL GRADIENT PROCEDURE FOR ISOLATION OF SYNAPTOSOMES DIRECTLY FROM AN S-1 FRACTION - HOMOGENEITY AND MORPHOLOGY OF SUBCELLULAR-FRACTIONS', BRAIN RESEARCH, 441 59-71 (1988)
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1988 |
Weinberger RP, Rostas JA, 'Developmental changes in protein phosphorylation in chicken forebrain. I. cAMP-stimulated phosphorylation.', Brain Research, 471 249-257 (1988)
The net level of cyclic AMP-stimulated protein phosphorylation was investigated in cytosolic and membrane fractions from chicken forebrain between embryonic day 13 (E13) and 52 da... [more]
The net level of cyclic AMP-stimulated protein phosphorylation was investigated in cytosolic and membrane fractions from chicken forebrain between embryonic day 13 (E13) and 52 days post-hatching. Throughout this period the majority of the net level of cAMP-stimulated phosphorylation of endogenous proteins was in the cytosolic fractions. Between day -8 (E13) and adult, the net level of cAMP-stimulated phosphorylation of endogenous proteins in the cytosol (S3) and crude synaptic plasma membrane (P2-M) fractions fell by 3 and 4 fold, respectively, when expressed per mg protein and rose by 5 and 10 fold, respectively, when expressed per fraction. The changes in specific activity were completed by 6-15 days post-hatching. The occluded cytosol (P2-S) fraction showed little change in the net level of cAMP-stimulated phosphorylation of endogenous proteins per mg protein. Major changes in phosphoprotein patterns involving both decreases and increases in phosphorylation occurred in all fractions from day -8 (E13) to day 6 post-hatch; thereafter the phosphoprotein bands and their relative intensities were unchanged. Three bands (P90 in S3; P41 and P31 in P2-M) contained major cAMP-stimulated phosphoproteins in embryonic brain but were absent after hatching. When cAMP-stimulated phosphorylation activity was measured in S3 and P-2M using an exogenous peptide substrate (Kemptide) there was no change in kinase activity per mg protein between day -8 (E13) and 30 days post-hatch. This suggests that the decrease in the net level of cAMP stimulated phosphorylation of endogenous proteins was due to the decrease in levels of endogenous phosphoproteins rather than protein kinase activity.(ABSTRACT TRUNCATED AT 250 WORDS)
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1988 |
Weinberger RP, Rostas JA, 'Developmental changes in protein phosphorylation in chicken forebrain. II. Calmodulin stimulated phosphorylation.', Brain Research, 471 259-272 (1988)
The development of calmodulin stimulated protein phosphorylation, with particular reference to calmodulin-stimulated protein kinase II (CMK II), was investigated in 3 subcellular ... [more]
The development of calmodulin stimulated protein phosphorylation, with particular reference to calmodulin-stimulated protein kinase II (CMK II), was investigated in 3 subcellular fractions of chicken forebrain: cytosol (S3), crude synaptic plasma membranes (P2-M) and occluded cytosol (P2-S). Changes in the level of calmodulin-stimulated phosphorylation of endogenous proteins occurred over a protracted time course and were not complete until after day 52 post-hatching. By day 15 post-hatching, calmodulin-stimulated phosphoproteins characteristic of embryonic fractions had all disappeared and those characteristic of adult tissue were present but not necessarily at their mature levels. The levels of CMK II were estimated from the autophosphorylation of the alpha-subunit which was the only phosphoprotein present at 53,000 Da in the 3 fractions. Overall, calmodulin-stimulated phosphorylation and CMK II levels were low in embryonic brain and high in adult brain but two specific changes in CMK II were observed during development: (1) although CMK II concentrations increased in both membrane and cytosolic fractions until day 23 the kinase was predominantly cytoplasmic (approximately 75%) until day 23, after which it became increasingly membrane bound so that by day 52 post-hatching the majority of CMK II was present in the synaptic membrane fraction, and (2) the relative concentrations of the alpha- and beta-subunits changed from an alpha:beta-value of approximately 1:1 in the 19 day embryo to approximately 1:2 by 15 days post-hatch after which no further change was seen. The occurrence of major changes in the calmodulin stimulated protein phosphorylation system for up to 6-8 weeks after synapse formation is completed in the forebrain, provides further support for the existence of a synapse maturation phase of neuronal differentiation which is distinct from synapse formation. This phase involves only a specific subset of the developmental changes occurring in the calmodulin-stimulated phosphorylation system.
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1988 |
ROSTAS JAP, SECCOMBE M, WEINBERGER RP, '2 DEVELOPMENTALLY REGULATED ISOENZYMES OF CALMODULIN-STIMULATED PROTEIN KINASE-II IN RAT FOREBRAIN', JOURNAL OF NEUROCHEMISTRY, 50 945-953 (1988)
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1988 |
DUNKLEY PR, JARVIE PE, ROSTAS JAP, 'DISTRIBUTION OF CALMODULIN-STIMULATED AND CYCLIC AMP-STIMULATED PROTEIN-KINASES IN SYNAPTOSOMES', JOURNAL OF NEUROCHEMISTRY, 51 57-68 (1988)
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1988 |
WEINBERGER RP, ROSTAS JAP, 'DEVELOPMENTAL-CHANGES IN PROTEIN-PHOSPHORYLATION IN CHICKEN FOREBRAIN .1. CAMP-STIMULATED PHOSPHORYLATION', DEVELOPMENTAL BRAIN RESEARCH, 43 249-257 (1988)
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1988 |
WEINBERGER RP, ROSTAS JAP, 'DEVELOPMENTAL-CHANGES IN PROTEIN-PHOSPHORYLATION IN CHICKEN FOREBRAIN .2. CALMODULIN STIMULATED PHOSPHORYLATION', DEVELOPMENTAL BRAIN RESEARCH, 43 259-272 (1988)
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1988 |
DICKINSON JA, ROSTAS JAP, NICHOLS B, EBELING W, DICKESON J, MATTHEWS D, et al., 'THE USE OF COTININE TO VALIDATE SMOKING SELF-REPORT IN PRIMARY CARE', COMMUNITY HEALTH STUDIES, 12 472-473 (1988) |
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1987 |
SHELDRAKE RF, CROCKER BD, HUSBAND AJ, ROSTAS JAP, 'ISOLATION AND PURIFICATION OF A THY-1-LIKE GLYCOPROTEIN FROM SHEEP BRAIN AND ITS DISTRIBUTION IN OVINE TISSUES', RESEARCH IN VETERINARY SCIENCE, 42 358-364 (1987)
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1987 |
Rostas JAP, Brent V, Dunkley PR, 'The effect of calmodulin and autophosphorylation on the activity of calmodulin-stimulated protein kinase II', Neuroscience Research Communications, 1 3-8 (1987)
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1986 |
DUNKLEY PR, JARVIE PE, HEATH JW, KIDD GJ, ROSTAS JAP, 'A RAPID METHOD FOR ISOLATION OF SYNAPTOSOMES ON PERCOLL GRADIENTS', BRAIN RESEARCH, 372 115-129 (1986)
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1986 |
Sedman GL, Jeffrey PL, Austin L, Rostas JA, 'The metabolic turnover of the major proteins of the postsynaptic density.', Brain Research, 387 221-230 (1986)
We have used the method of Austin, Lowry, Brown and Carter, to measure the steady-state metabolic half-life of tubulin (alpha and beta individually) and actin (beta and gamma toge... [more]
We have used the method of Austin, Lowry, Brown and Carter, to measure the steady-state metabolic half-life of tubulin (alpha and beta individually) and actin (beta and gamma together) in the total cytosolic (S3), microsomal (P3), synaptic plasma membrane (SPM) and synaptic junction (SJ) subcellular fractions from 6-day-old and adult chicken forebrain. In the SPM and SJ fractions we also measured the steady-state metabolic half-life of the major postsynaptic density protein (mPSDp). In SPM and SJ fractions from 6-day-old chickens tubulin and actin turned over approximately twice as slowly (t1/2 approximately equal to 24 days) as tubulin and actin in the S3 fraction (t1/2 approximately equal to 13 days). This difference was unlikely merely to be due to association with membranes since the t1/2 values for the proteins were the same in P3 and S3. The estimated t1/2 values for mPSDp were similar to that for tubulin and actin in SPM and SJ fractions. Similar results were obtained in adult chickens except that all t1/2 values in all fractions were approximately 30% larger. The calculated t1/2 values did not change between labelling periods of 4 and 6.5 h suggesting that the lag phase of incorporation of newly synthesized PSD proteins is sufficiently rapid to not produce this result artefactually. When the brain from a non-labelled chicken was homogenized in the presence of the S3 fraction from a labelled chicken and sub-fractionated the relative specific activities of the SPM and SJ fractions produced were 1-2% of those from the labelled brain. These results support the notion that tubulin and actin are intrinsic components of the PSD.
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1986 |
Weinberger RP, Rostas JA, 'Subcellular distribution of a calmodulin-dependent protein kinase activity in rat cerebral cortex during development.', Brain research, 394 37-50 (1986)
The postnatal development of calmodulin-stimulated phosphorylation of endogenous proteins, in particular the autophosphorylated subunits of the calmodulin-stimulated protein kinas... [more]
The postnatal development of calmodulin-stimulated phosphorylation of endogenous proteins, in particular the autophosphorylated subunits of the calmodulin-stimulated protein kinase II, were investigated in subcellular fractions of rat cerebral cortex. The major subunit had a mol. wt. of 53,000 Da (designated 50 kDa) and the minor one a mol. wt. of 63,000 Da (designated 60 kDa). The 50-kDa subunit was found to be the only significant phosphoprotein in each fraction and throughout development at its molecular weight. However, the 60-kDa subunit was found to comigrate with other phosphoproteins that accounted for up to 15% of the radioactivity at this molecular weight and which differed between the fractions. 50-kDa autophosphorylation was found to be 3-fold greater in cytoplasmic fractions at day 10 and by adults was evenly distributed between membrane and cytoplasmic fractions. A similar pattern was also found for the total calmodulin-stimulated phosphorylation. Changes in autophosphorylation activity of the 50-kDa subunit were found to represent changes in kinase activity rather than alterations in phosphatase activity. In the membrane, this change was shown to be due to changes in the amount of enzyme. Although in the adult autophosphorylation activity is evenly distributed between membrane and soluble fractions, when differences in phosphatase activity and lack of autophosphorylation activity of the majority of post-synaptic density-associated kinase is taken into account, it is clear that the vast majority of the enzyme is membrane-bound. Phosphorylation of endogenous substrates paralleled the development of 50-kDa subunit autophosphorylation, most of which occurred between day 14 and day 30, a period which follows the most rapid phase of synaptogenesis. This pattern was different from that of the phosphorylation of myelin basic protein and two substrates of the calcium-phospholipid-dependent protein kinase. There was also a change in the ratio of autophosphorylation activity of the 50-kDa and 60-kDa subunits during development which appears to be due to a change in the amount of the subunits themselves. This ratio was the same in all fractions at any one age. We suggest that this change is due to the existence of at least two developmentally regulated isoenzymes in the cortex.
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1986 |
LEUNG WN, JEFFREY PL, ROSTAS JAP, 'EFFECT OF DENERVATION ON SARCOLEMMAL PROTEINS AND GLYCOPROTEINS OF FAST AND SLOW MAMMALIAN SKELETAL-MUSCLE', EXPERIMENTAL NEUROLOGY, 91 229-245 (1986)
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1986 |
ROSTAS JAP, WEINBERGER RP, DUNKLEY PR, 'MULTIPLE POOLS AND MULTIPLE FORMS OF CALMODULIN-STIMULATED PROTEIN-KINASE DURING DEVELOPMENT - RELATIONSHIP TO POSTSYNAPTIC DENSITIES', PROGRESS IN BRAIN RESEARCH, 69 355-371 (1986)
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1986 |
WEINBERGER RP, ROSTAS JAP, 'SUBCELLULAR-DISTRIBUTION OF A CALMODULIN-DEPENDENT PROTEIN-KINASE ACTIVITY IN RAT CEREBRAL-CORTEX DURING DEVELOPMENT', DEVELOPMENTAL BRAIN RESEARCH, 29 37-50 (1986)
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1986 |
SEDMAN GL, JEFFREY PL, AUSTIN L, ROSTAS JAP, 'THE METABOLIC TURNOVER OF THE MAJOR PROTEINS OF THE POSTSYNAPTIC DENSITY', MOLECULAR BRAIN RESEARCH, 1 221-230 (1986)
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1986 |
ROSTAS JAP, BRENT VA, HEATH JW, NEAME RLB, POWIS DA, WEINBERGER RP, DUNKLEY PR, 'THE SUBCELLULAR-DISTRIBUTION OF A MEMBRANE-BOUND CALMODULIN-STIMULATED PROTEIN-KINASE', NEUROCHEMICAL RESEARCH, 11 253-268 (1986)
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1985 |
JEFFREY PL, LEUNG WN, ROSTAS JAP, 'THE EFFECT OF TETRODOTOXIN ON MAMMALIAN SARCOLEMMAL PROTEINS AND GLYCOPROTEINS', BIOCHEMISTRY INTERNATIONAL, 10 715-722 (1985) |
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1984 |
LEUNG WN, JEFFREY PL, ROSTAS JAP, 'THE EFFECT OF DENERVATION ON MAMMALIAN SARCOLEMMAL PROTEINS AND GLYCOPROTEINS', MUSCLE & NERVE, 7 35-49 (1984)
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1984 |
ROSTAS JAP, BRENT VA, GULDNER FH, 'THE MATURATION OF POST-SYNAPTIC DENSITIES IN CHICKEN FOREBRAIN', NEUROSCIENCE LETTERS, 45 297-304 (1984)
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1984 |
SEDMAN GL, JEFFREY PL, ROSTAS JAP, 'THE TURNOVER RATES OF CHICK BRAIN SYNAPTIC JUNCTION PROTEINS', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 16 32-32 (1984) |
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1984 |
WEINBERGER RP, DUNKLEY PR, ROSTAS JAP, 'DEVELOPMENTAL ACCUMULATION OF A CALMODULIN STIMULATED PROTEIN-KINASE IN SYNAPTIC-MEMBRANES', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 16 87-87 (1984)
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1983 |
ROSTAS JAP, SHEVENAN TA, SINCLAIR CM, JEFFREY PL, 'THE PURIFICATION AND CHARACTERIZATION OF A THY-1-LIKE GLYCOPROTEIN FROM CHICKEN BRAIN', BIOCHEMICAL JOURNAL, 213 143-152 (1983)
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1983 |
ROSTAS JAP, BRENT VA, DUNKLEY PR, 'THE MAJOR CALMODULIN-STIMULATED PHOSPHOPROTEIN OF SYNAPTIC JUNCTIONS AND THE MAJOR POST-SYNAPTIC DENSITY PROTEIN ARE DISTINCT', NEUROSCIENCE LETTERS, 43 161-165 (1983)
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1982 |
LEUNG WN, JEFFREY PL, ROSTAS JAP, 'DENERVATION EXPOSES CRYPTIC CONCANAVALIN A BINDING-SITES IN SKELETAL-MUSCLE MEMBRANES', NEUROSCIENCE LETTERS, 30 31-36 (1982)
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1981 |
LEUNG WN, ROSTAS JAP, JEFFREY PL, 'PLASTICITY OF SKELETAL-MUSCLE MEMBRANES IN FOLLOWING DENERVATION', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 14 118-118 (1981) |
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1981 |
ROSTAS JAP, LEUNG WN, JEFFREY PL, 'GLYCOSYLTRANSFERASE ACTIVITIES IN CHICKEN BRAIN SYNAPTIC JUNCTIONS', NEUROSCIENCE LETTERS, 24 155-160 (1981)
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1981 |
ROSTAS JAP, JEFFREY PL, 'MATURATION OF SYNAPSES IN CHICKEN FOREBRAIN', NEUROSCIENCE LETTERS, 25 299-304 (1981)
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1980 |
ROSTAS JAP, SHEVENAN TA, JEFFREY PL, 'A DEVELOPMENTALLY REGULATED THY-1-LIKE MEMBRANE GLYCOPROTEIN IN CHICKENS', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 13 119-119 (1980)
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1979 |
ROSTAS JAP, KELLY PT, PESIN RH, COTMAN CW, 'PROTEIN AND GLYCOPROTEIN COMPOSITION OF SYNAPTIC JUNCTIONS PREPARED FROM DISCRETE SYNAPTIC REGIONS AND DIFFERENT SPECIES', BRAIN RESEARCH, 168 151-167 (1979)
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1979 |
ROSTAS JAP, AUSTIN L, JEFFREY PL, 'SELECTIVE LABELING OF 2 PHASES OF AXONAL-TRANSPORT OF CHOLESTEROL IN THE CHICK OPTIC-SYSTEM', JOURNAL OF NEUROCHEMISTRY, 32 1461-1466 (1979)
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1979 |
LEUNG WN, ROSTAS JAP, JEFFREY PL, 'ALTERATIONS IN SURFACE-MEMBRANES OF MAMMALIAN SKELETAL-MUSCLE FOLLOWING DENERVATION', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 12 93-93 (1979) |
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1979 |
JEFFREY PL, LEUNG WN, ROSTAS JAP, 'DENERVATION ALTERATIONS IN SURFACE-MEMBRANES OF MAMMALIAN SKELETAL-MUSCLE', MUSCLE & NERVE, 2 310-310 (1979) |
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1977 |
ROSTAS JAP, KELLY PT, COTMAN CW, 'IDENTIFICATION OF MEMBRANE GLYCO-COMPONENTS IN POLYACRYLAMIDE GELS - RAPID METHOD USING I-125-LABELED LECTINS', ANALYTICAL BIOCHEMISTRY, 80 366-372 (1977)
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1977 |
HOWE PRC, FENWICK EM, ROSTAS JAP, LIVETT BG, 'IMMUNOCHEMICAL COMPARISON OF SYNAPTIC PLASMA-MEMBRANE AND SYNAPTIC VESICLE MEMBRANE ANTIGENS', JOURNAL OF NEUROCYTOLOGY, 6 339-352 (1977)
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1977 |
ROSTAS JAP, JEFFREY PL, 'IMMUNOCHEMICAL CHARACTERIZATION OF SYNAPTOSOMAL MEMBRANE ANTIGENS FROM CHICKEN BRAIN - HISTOCHEMICAL LOCALIZATION IN DAY-OLD CHICK', NEUROCHEMICAL RESEARCH, 2 59-85 (1977)
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1977 |
ROSTAS JAP, JEFFREY PL, 'IMMUNOCHEMICAL CHARACTERIZATION OF SYNAPTOSOMAL MEMBRANE ANTIGENS FROM CHICKEN BRAIN - HISTOCHEMICAL DEMONSTRATION OF CHANGES IN DISTRIBUTION DURING DEVELOPMENT', NEUROCHEMICAL RESEARCH, 2 171-189 (1977)
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1977 |
ROSTAS JAP, JEFFREY PL, 'IMMUNOCHEMICAL CHARACTERIZATION OF SYNAPTOSOMAL MEMBRANE ANTIGENS FROM CHICKEN BRAIN - QUANTITATIVE-DETERMINATION AND PARTIAL CHARACTERIZATION', NEUROCHEMICAL RESEARCH, 2 395-406 (1977)
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1975 |
ROSTAS JAP, MCGREGOR A, JEFFREY PL, 'TRANSPORT OF CHOLESTEROL IN CHICK OPTIC-SYSTEM', JOURNAL OF NEUROCHEMISTRY, 24 295-302 (1975)
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1975 |
HOWE PRC, ROSTAS JAP, FENWICK EM, LIVETT BG, 'FURTHER EVIDENCE FOR INCORPORATION OF SYNAPTIC VESICLE PROTEINS INTO SYNAPTOSOMAL PLASMA-MEMBRANES', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 8 95-95 (1975)
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1975 |
ROSTAS JAP, JEFFREY PL, 'ANTIGENIC MEMBRANE COMPONENTS IN DEVELOPING NERVE-CELLS', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 8 117-117 (1975) |
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1975 |
ROSTAS JAP, JEFFREY PL, 'RESTRICTED MOBILITY OF NEURONAL MEMBRANE ANTIGENS', NEUROSCIENCE LETTERS, 1 47-53 (1975)
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1974 |
LIVETT BG, ROSTAS JAP, JEFFREY PL, AUSTIN L, 'ANTIGENICITY OF ISOLATED SYNAPTOSOMAL MEMBRANES', EXPERIMENTAL NEUROLOGY, 43 330-338 (1974)
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1974 |
ROSTAS JAP, MCGREGOR A, JEFFREY PL, AUSTIN L, 'CHOLESTEROL TRANSPORT IN CRANIAL AND PERIPHERAL-NERVES', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 7 35-35 (1974) |
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1973 |
ROSTAS JAP, JEFFREY PL, 'UNUSUAL DISRUPTION OF SYNAPTOSOMES BY FRENCH PRESS TREATMENT', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 6 46-46 (1973) |
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