Dr Chen Chen Jiang

Dr Chen Chen Jiang

Cancer Institute NSW Career Development Fellow

School of Medicine and Public Health

Career Summary

Biography

Dr Chen Chen Jiang is a Cancer Institute NSW Career Development Fellow. She has been working on translational research in melanoma with a focused theme of “overcoming resistance of metastatic melanoma to treatment” for more than 10 years. She is currently in charge of the signal transduction team in the Melanoma Research Laboratory, which includes 3 research assistants and 3 PhD students.

Research support:  As a researcher still in the early/middle stage of her career, Dr Jiang as a chief investigator has received 1 NHMRC Project Grant ($341,175), 1 NHMRC Equipment Grant ($ 24,596) and 2 Cancer Council NSW Project Grants in the last five years ($718,500). As CIA, she received a Cure Cancer Australia Foundation Project Grant in 2010 ($90,000).  She was awarded an NHMRC training (postdoctoral) fellowship in 2011 ($320,032), and a highly competitive Cancer Institute NSW Career Development Fellowship in 2014 ($600,000).  In addition, she has received a number of competitive grants from other sources.

 

International and national standing:Dr Jiang’s work has resulted in 62 research publications in high impact journals including Nature Communications, PNAS, Cancer Research, Clinical Cancer Research, Autophagy, Oncogene, Cell Death and Differentiation and Cell Death and Diseases. Her career publications have attracted more than 1500 citations with H-index at 21 and Scopus H-index at18. 

 

Dr Jiang has served as a reviewer to assess grant applications for national and international funding bodies including NHMRC, the Cure Cancer Australia Foundation and the National Natural Science Fund of China. She was a Grant Review Committee member of Cancer Australia in 2014. 

Dr Jiang also serves as a regular reviewer for a number of journals including Clinical Cancer Research and Molecular Cancer Research.

She acted as the chair of the Scientific Program Committee of the Australian Society for Medical Research(ASMR)Satellite Scientific Meeting in Newcastle March 2014.

She was awarded the “Woman in Cancer Research Award” and the “Sanofi-Aventis Scholar-in-training Award” by the AACR in 2015 and 2010, respectively.

 

Collaborations:Dr Jiang has ongoing collaborations with a large number of researchers locally, nationally, and internationally. She has established productive collaborations with Prof Rodney Scott locally and Profs Richard Kefford and Richard Scolyer nationally. She has also established collaborations with researchers from many universities in China.  Her productive collaborations with researchers in China not only allows her to attract high quality students and visiting academics, but also enables her to apply for funding as a collaborator from various sources in China.

 

Supervision:In the last 5 years, Dr Jiang has supervised 5 PhD students and 8 visiting academics. All of these students and visiting academics have proven highly productive under her supervision, as evidenced by their awards for presentations at scientific conferences and their publications in high impact journals.

 

Professional involvment: Dr Jiang actively participates in activities of academic organisations. She is a member of AACR, the Australia and New Zealand Melanoma Trials Group, the Melanoma Tumour Group of the Hunter New England Area Health, and ASMR.

Community engagement and participation:Dr Jiang regularly presents her work to various community groups and writes newsletters for local medical research associations. Through collaboration with pharmaceutical companies, her research has contributed to the decision-making in planning and executing clinical trials with targeted inhibitors of the MAPK pathway.

 

Contribution to field of research: Dr Jiang pioneered studies on “understanding adaptive mechanisms of melanoma cells to endoplasmic reticulum (ER) stress”, which has provided a number of insights into resistance mechanisms of melanoma to apoptosis induced by ER stress. No one else has investigated ER stress in melanoma, and its effect on melanoma cell survival and responses to treatment, as systematically and as comprehensively as she has. She was also among the first to show that the inappropriate activation of survival pathways plays a critical role in the resistance of melanoma cells to apoptosis induced by various chemotherapeutic drugs. In addition, Dr Jiang was also among the first to show that MEK-independent mechanisms play an important role in resistance of melanoma cells to targeted inhibitors of mutant BRAF. More recently, she has become a leading figure in the investigation of the roles of microRNAs in the regulation of melanoma cell survival and proliferation.

 



Qualifications

  • PhD (Surgical Science), University of Newcastle
  • Bachelor of Medicine, Bengbu Medical College - China
  • Master of Applied Science (Biotechnology), University of Western Sydney

Keywords

  • Carcinogenesis
  • Oncology
  • cancer
  • cell death
  • overcome resistance of cancer cells to treatment
  • signal transduction

Languages

  • English (Fluent)
  • Mandarin (Mother)

Fields of Research

Code Description Percentage
111299 Oncology and Carcinogenesis not elsewhere classified 30
111201 Cancer Cell Biology 70

Professional Experience

UON Appointment

Title Organisation / Department
Cancer Institute NSW Career Develop University of Newcastle
School of Medicine and Public Health
Australia

Academic appointment

Dates Title Organisation / Department
1/06/2011 - 1/06/2015 Fellow - NHMRC University of Newcastle
School of Medicine and Public Health
Australia

Awards

Member

Year Award
2008 Runner-up of Student Poster award
Hunter Medical Research Institute (HMRI)

Prize

Year Award
2008 Best research showcase
Faculty of Health, University of Newcastle

Professional

Year Award
2015 AACR Woman in Cancer Research Award
American Association for Cancer Research (AACR)
2010 AACR Sanofi-Aventis Scholar-in-training Award
American Association for Cancer Research (AACR)

Invitations

Committee Member

Year Title / Rationale
2014 ASMR Satellite Scientific Meeting

Panel Participant

Year Title / Rationale
2015 Receptor-Interacting Protein Kinase 1 functions as an oncogenic regulator in human melanoma.
2015 Receptor-Interacting Protein Kinase 1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy
2015 MicroRNA regulation of INPP4B to promote melanoma cell proliferation through PI3K/SGK3.
2013 Co-targeting histone deacetylase inhibitor and oncogenic BRAF synergistically kill human melanoma cells by caspase-independent cell death
2013 Inhibition of oncogenic BRAF triggers immunogenic necrosis of human melanoma cells.
2013 PHLPP1 deactivates Akt and has a tumor suppressive role in human melanoma
2010 Transcriptional up-regulation of Mcl-1 by ETS1 down-stream of XBP-1 in melanoma cells upon ER stress
2010 Long-term exposure to the BRAFV600E inhibitor PLX4720 results in melanoma cells with increased activation of ERK1/2 and high proliferation potential.

Participant

Year Title / Rationale
2012 The cancer testis antigen MAGE-D2 protects human melanoma cells from TRAIL-induced apoptosis by suppressing TRAIL-R2 expression
2012 PP2A signalling is overridden by MEK/ERK activity leading to suppression of Bim and progection of melanoma cells upon ER stress
2010 Adaptation to ER stress as a driver of increased expression of Mcl-1 with melanoma progression.
2010 Apoptosis response of mutant B-RAF human melanoma cells to a B-RAF inhibitor involves increased splicing production of BimS.

Prestigious works

Year Commenced Year Finished Prestigious Work Role
2014 2015 Member of The Australian Society for Medical Research (ASMR) member Member
2012 2015 The Melanoma Tumour Group of the Hunter New England Area Health Member Member
2010 2015 Member of The Australia and New Zealand Melanoma Trials Group (ANZMTG) member Member
2010 2015 Member of The Melanoma Institute of Australia (MIA) Member Member
2007 2015 Member of The American Association for Cancer Research (AACR) Member Member
2007 2015 Member of The Hunter Medical Research Institute (HMRI) member Member
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Highlighted Publications

Year Citation Altmetrics Link
2007 Jiang CC, Li HC, Gillespie S, Kiejda KA, Mhaidat N, Yu FW, et al., 'Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response', Cancer Research, 67 5880-5888 (2007) [C1]
DOI 10.1158/0008-5472.CAN-07-0213
Citations Scopus - 70Web of Science - 65
Co-authors Kelly Kiejda, Xu Zhang, Rick Thorne
2007 Jiang CC, Li HC, Gillespie S, Yu FW, Kiejda KA, Zhang XD, Hersey P, 'Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis', Cancer Research, 67 9750-9761 (2007) [C1]
DOI 10.1158/0008-5472.CAN-07-2047
Citations Scopus - 90Web of Science - 78
Co-authors Xu Zhang, Kelly Kiejda
2008 Zhang XD, Jiang C, Kiejda KA, Lucas K, Wade M, Allen J, Hersey P, 'Up-regulation of Mcl-1 by the unfolded protein response is critical for survival of melanoma cells upon ER stress.', Pigment Cell Melanoma Res., 257-277 (2008)
2008 Jiang CC, Lucas K, Kiejda KA, Wade M, Debock CE, Thorne RF, et al., 'Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress', Cancer Research, 68 6708-6717 (2008) [C1]
DOI 10.1158/0008-5472.can-08-0349
Citations Scopus - 81Web of Science - 73
Co-authors Rick Thorne, Kelly Kiejda, Xu Zhang
2011 Jiang CC, Lai F, Thorne RF, Yang F, Liu H, Hersey P, Zhang XD, 'MEK-independent survival of B-RAFV600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720', Clinical Cancer Research, 17 721-730 (2011) [C1]
Citations Scopus - 63Web of Science - 57
Co-authors Rick Thorne, Xu Zhang
2011 Jin L, Hu WL, Jiang CC, Wang JX, Han CC, Chu P, et al., 'MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma', Proceedings of the National Academy of Sciences, 108 15840-15845 (2011) [C1]
Citations Scopus - 77Web of Science - 64
Co-authors Lei Jin, Rick Thorne, Xu Zhang
2013 Guo ST, Jiang CC, Wang GP, Li YP, Wang CY, Guo XY, et al., 'MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer', ONCOGENE, 32 1910-1920 (2013) [C1]
DOI 10.1038/onc.2012.214
Citations Scopus - 80Web of Science - 44
Co-authors Lei Jin, Rick Thorne, Xu Zhang
2015 Jiang C, Chi MN, Guo ST, Wilmott JS, Guo X Y, Yan X G, et al., 'INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas', Oncotarget, 6 39891-39907 (2015) [C1]
DOI 10.18632/oncotarget.5359
Citations Scopus - 2
Co-authors Xu Zhang, Hubert Hondermarck, Lei Jin

Journal article (70 outputs)

Year Citation Altmetrics Link
2016 Wang CY, Guo ST, Wang JY, Liu F, Zhang YY, Yari H, et al., 'Inhibition of HSP90 by AUY922 Preferentially Kills Mutant KRAS Colon Cancer Cells by Activating Bim through ER Stress.', Mol Cancer Ther, 15 448-459 (2016)
DOI 10.1158/1535-7163.MCT-15-0778
Co-authors Xu Zhang
2016 Chen J, Jiang CC, Jin L, Zhang XD, 'Regulation of PD-L1: a novel role of pro-survival signalling in cancer.', Ann Oncol, 27 409-416 (2016)
DOI 10.1093/annonc/mdv615
Citations Scopus - 2
Co-authors Xu Zhang, Lei Jin
2016 Jin L, Chen J, Liu XY, Jiang CC, Zhang XD, 'The double life of RIPK1.', Mol Cell Oncol, 3 e1035690 (2016)
DOI 10.1080/23723556.2015.1035690
Co-authors Xu Zhang
2016 Wang JY, Jin L, Yan XG, Sherwin S, Farrelly M, Zhang YY, et al., 'Reactive oxygen species dictate the apoptotic response of melanoma cells to TH588.', J Invest Dermatol, (2016)
DOI 10.1016/j.jid.2016.06.625
2016 Wang CY, Guo ST, Wang JY, Yan XG, Farrelly M, Zhang YY, et al., 'Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922.', Oncotarget, (2016)
DOI 10.18632/oncotarget.10414
2016 Guo ST, Chi MN, Yang RH, Guo XY, Zan LK, Wang CY, et al., 'INPP4B is an oncogenic regulator in human colon cancer.', Oncogene, 35 3049-3061 (2016)
DOI 10.1038/onc.2015.361
Co-authors Hubert Hondermarck, Xu Zhang, Stephen Ackland, Rodney Scott, Rick Thorne
2016 Huang YY, Pu LJ, Song LL, Ma LY, Liu H, Jiang CC, 'Knockdown of GRP78 enhances cell death by cisplatin and radiotherapy in nasopharyngeal cells.', Anticancer Drugs, (2016)
DOI 10.1097/CAD.0000000000000377
2015 Roselli S, Pundavela J, Demont Y, Faulkner S, Keene S, Attia J, et al., 'Sortilin is associated with breast cancer aggressiveness and contributes to tumor cell adhesion and invasion', Oncotarget, 6 10473-10486 (2015) [C1]

The neuronal membrane protein sortilin has been reported in a few cancer cell lines, but its expression and impact in human tumors is unclear. In this study, sortilin was analyzed... [more]

The neuronal membrane protein sortilin has been reported in a few cancer cell lines, but its expression and impact in human tumors is unclear. In this study, sortilin was analyzed by immunohistochemistry in a series of 318 clinically annotated breast cancers and 53 normal breast tissues. Sortilin was detected in epithelial cells, with increased levels in cancers, as compared to normal tissues (p = 0.0088). It was found in 79% of invasive ductal carcinomas and 54% of invasive lobular carcinomas (p < 0.0001). There was an association between sortilin expression and lymph node involvement (p = 0.0093), suggesting a relationship with metastatic potential. In cell culture, sortilin levels were higher in cancer cell lines compared to non-tumorigenic breast epithelial cells and siRNA knockdown of sortilin inhibited cancer cell adhesion, while proliferation and apoptosis were not affected. Breast cancer cell migration and invasion were also inhibited by sortilin knockdown, with a decrease in focal adhesion kinase and SRC phosphorylation. In conclusion, sortilin participates in breast tumor aggressiveness and may constitute a new therapeutic target against tumor cell invasion.

Citations Scopus - 3
Co-authors Hubert Hondermarck, John Attia, Marjorie Walker, Xu Zhang
2015 Tay KH, Liu X, Chi M, Jin L, Jiang CC, Guo ST, et al., 'Involvement of vacuolar H+-ATPase in killing of human melanoma cells by the sphingosine kinase analogue FTY720', Pigment Cell and Melanoma Research, 28 171-183 (2015) [C1]

© 2014 John Wiley & Sons A/S.Targeting the sphingosine 1-phosphate (S1P)/S1P receptor (S1PR) signalling axis is emerging as a promising strategy in the treatment of cancer. Howev... [more]

© 2014 John Wiley & Sons A/S.Targeting the sphingosine 1-phosphate (S1P)/S1P receptor (S1PR) signalling axis is emerging as a promising strategy in the treatment of cancer. However, the effect of such an approach on survival of human melanoma cells remains less understood. Here, we show that the sphingosine analogue FTY720 that functionally antagonises S1PRs kills human melanoma cells through a mechanism involving the vacuolar H+-ATPase activity. Moreover, we demonstrate that FTY720-triggered cell death is characterized by features of necrosis and is not dependent on receptor-interacting protein kinase 1 or lysosome cathepsins, nor was it associated with the activation of protein phosphatase 2A. Instead, it is mediated by increased production of reactive oxygen species and is antagonized by activation of autophagy. Collectively, these results suggest that FTY720 and its analogues are promising candidates for further development as new therapeutic agents in the treatment of melanoma.

DOI 10.1111/pcmr.12326
Citations Scopus - 1Web of Science - 1
Co-authors Lei Jin, Nikki Verrills, Xu Zhang
2015 Luan Q, Jin L, Jiang CC, Tay KH, Lai F, Liu XY, et al., 'RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy.', Autophagy, 11 975-994 (2015) [C1]
DOI 10.1080/15548627.2015.1049800
Citations Scopus - 4
Co-authors Xu Zhang
2015 Sun Y, Liu Z, Zou X, Lan Y, Sun X, Wang X, et al., 'Mechanisms underlying 3-bromopyruvate-induced cell death in colon cancer', JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 47 319-329 (2015) [C1]
DOI 10.1007/s10863-015-9612-1
Citations Scopus - 1
2015 Jiang C, Chi MN, Guo ST, Wilmott JS, Guo X Y, Yan X G, et al., 'INPP4B is upregulated and functions as an oncogenic driver through SGK3 in a subset of melanomas', Oncotarget, 6 39891-39907 (2015) [C1]
DOI 10.18632/oncotarget.5359
Citations Scopus - 2
Co-authors Xu Zhang, Hubert Hondermarck, Lei Jin
2015 Zhao S, Li H, Jiang C, Ma T, Wu C, Huo Q, Liu H, '17-Demethoxy-reblastatin, an Hsp90 inhibitor, induces mitochondria-mediated apoptosis through downregulation of Mcl-1 in human hepatocellular carcinoma cells', JOURNAL OF BIOENERGETICS AND BIOMEMBRANES, 47 373-381 (2015) [C1]
DOI 10.1007/s10863-015-9620-1
2015 Liu XY, Lai F, Yan XG, Jiang CC, Guo ST, Wang CY, et al., 'RIP1 kinase is an oncogenic driver in melanoma', Cancer Research, 75 1736-1748 (2015) [C1]

© 2015 AACR.Although many studies have uncovered an important role for the receptor-binding protein kinase RIP1 in controlling cell death signaling, its possible contributions to... [more]

© 2015 AACR.Although many studies have uncovered an important role for the receptor-binding protein kinase RIP1 in controlling cell death signaling, its possible contributions to cancer pathogenesis have been little explored. Here, we report that RIP1 functions as an oncogenic driver in human melanoma. Although RIP1 was commonly upregulated in melanoma, RIP1 silencing inhibited melanoma cell proliferation in vitro and retarded the growth of melanoma xenografts in vivo. Conversely, while inducing apoptosis in a small proportion of melanoma cells, RIP1 overexpression enhanced proliferation in the remaining cells. Mechanistic investigations revealed that the proliferative effects of RIP1 overexpression were mediated by NF-¿B activation. Strikingly, ectopic expression of RIP1 enhanced the proliferation of primary melanocytes, triggering their anchorageindependent cell growth in an NF-¿B-dependent manner. We identified DNA copy-number gain and constitutive ubiquitination by a TNFa autocrine loop mechanism as two mechanisms of RIP1 upregulation in human melanomas. Collectively, our findings define RIP1 as an oncogenic driver in melanoma, with potential implications for targeting its NF-¿B-dependent activation mechanism as a novel approach to treat this disease.

DOI 10.1158/0008-5472.CAN-14-2199
Citations Scopus - 2Web of Science - 1
Co-authors Lei Jin, Xu Zhang
2015 Zou X, Zhang M, Sun Y, Zhao S, Wei Y, Zhang X, et al., 'Inhibitory effects of 3-bromopyruvate in human nasopharyngeal carcinoma cells', ONCOLOGY REPORTS, 34 1895-1904 (2015) [C1]
DOI 10.3892/or.2015.4147
Co-authors Xu Zhang
2014 Dong L, Jin L, Tseng HY, Wang CY, Wilmott JS, Yosufi B, et al., 'Oncogenic suppression of PHLPP1 in human melanoma', Oncogene, 33 4756-4766 (2014)

© 2014 Macmillan Publishers Limited.Akt is constitutively activated in up to 70% of human melanomas and has an important role in the pathogenesis of the disease. However, little ... [more]

© 2014 Macmillan Publishers Limited.Akt is constitutively activated in up to 70% of human melanomas and has an important role in the pathogenesis of the disease. However, little is known about protein phosphatases that dephosphorylate and thereby inactivate it in melanoma cells. Here we report that suppression of pleckstrin homology domain and leucine-rich repeat Ser/Thr protein phosphatase 1 (PHLPP1) by DNA methylation promotes Akt activation and has an oncogenic role in melanoma. While it is commonly downregulated, overexpression of PHLPP1 reduces Akt activation and inhibits melanoma cell proliferation in vitro, and retards melanoma growth in a xenograft model. In contrast, knockdown of PHLPP1 increases Akt activation, enhances melanoma cell and melanocyte proliferation, and results in anchorage-independent growth of melanocytes. Suppression of PHLPP1 involves blockade of binding of the transcription factor Sp1 to the PHLPP1 promoter. Collectively, these results suggest that suppression of PHLPP1 by DNA methylation contributes to melanoma development and progression.

DOI 10.1038/onc.2013.420
Citations Scopus - 4
Co-authors Xu Zhang
2014 Liu YL, Lai F, Wilmott JS, Yan XG, Liu XY, Luan Q, et al., 'Noxa upregulation by oncogenic activation of MEK/ERK through CREB promotes autophagy in human melanoma cells', Oncotarget, 5 11237-11251 (2014) [C1]

Reduction in the expression of the anti-survival BH3-only proteins PUMA and Bim is associated with the pathogenesis of melanoma. However, we have found that the expression of the ... [more]

Reduction in the expression of the anti-survival BH3-only proteins PUMA and Bim is associated with the pathogenesis of melanoma. However, we have found that the expression of the other BH3-only protein Noxa is commonly upregulated in melanoma cells, and that this is driven by oncogenic activation of MEK/ERK. Immunohistochemistry studies showed that Noxa was expressed at higher levels in melanomas than nevi. Moreover, the expression of Noxa was increased in metastatic compared to primary melanomas, and in thick primaries compared to thin primaries. Inhibition of oncogenic BRAFV600E or MEK downregulated Noxa, whereas activation of MEK/ERK caused its upregulation. In addition, introduction of BRAFV600E increased Noxa expression in melanocytes. Upregulation of Noxa was due to a transcriptional increase mediated by cAMP responsive element binding protein, activation of which was also increased by MEK/ERK signaling in melanoma cells. Significantly, Noxa appeared necessary for constitutive activation of autophagy, albeit at low levels, by MEK/ERK in melanoma cells. Furthermore, it was required for autophagy activation that delayed apoptosis in melanoma cells undergoing nutrient deprivation. These results reveal that oncogenic activation of MEK/ERK drives Noxa expression to promote autophagy, and suggest that Noxa has an indirect anti-apoptosis role in melanoma cells under nutrient starvation conditions.

Citations Scopus - 8Web of Science - 3
Co-authors Xu Zhang, Lei Jin
2014 Croft A, Tay KH, Boyd SC, Guo ST, Jiang CC, Lai F, et al., 'Oncogenic activation of MEK/ERK primes melanoma cells for adaptation to endoplasmic reticulum stress', Journal of Investigative Dermatology, 134 488-497 (2014) [C1]

Cancer cells commonly undergo chronic endoplasmic reticulum (ER) stress, to which the cells have to adapt for survival and proliferation. We report here that in melanoma cells int... [more]

Cancer cells commonly undergo chronic endoplasmic reticulum (ER) stress, to which the cells have to adapt for survival and proliferation. We report here that in melanoma cells intrinsic activation of the ER stress response/unfolded protein response (UPR) is, at least in part, caused by increased outputs of protein synthesis driven by oncogenic activation of mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) and promotes proliferation and protects against apoptosis induced by acute ER stress. Inhibition of oncogenic BRAF V600E or MEK-attenuated activation of inositol-requiring enzyme 1 (IRE1) and activating transcription factor 6 (ATF6) signaling of the UPR in melanoma cells. This was associated with decreased phosphorylation of eukaryotic initiation factor 4E (eIF4E) and nascent protein synthesis and was recapitulated by knockdown of eIF4E. In line with this, introduction of BRAF V600E into melanocytes led to increases in eIF4E phosphorylation and protein production and triggered activation of the UPR. Similar to knockdown of glucose-regulated protein 78 (GRP78), inhibition of XBP1 decelerated melanoma cell proliferation and enhanced apoptosis induced by the pharmacological ER stress inducers tunicamycin and thapasigargin. Collectively, these results reveal that potentiation of adaptation to chronic ER stress is another mechanism by which oncogenic activation of the MEK/ERK pathway promotes the pathogenesis of melanoma. © 2014 The Society for Investigative Dermatology.

DOI 10.1038/jid.2013.325
Citations Scopus - 21Web of Science - 12
Co-authors Xu Zhang, Lei Jin
2014 Zhao RS, Zhang YY, Wu CZ, Li HM, Jiang C, Jiang ZW, Liu H, '3-bromopyruvate enhances cisplatin sensitivity of hepatocellular carcinoma cells in vitro.', Nan Fang Yi Ke Da Xue Xue Bao = Journal of Southern Medical University, 34 25-30 (2014) [C1]
2014 Tay KH, Luan Q, Croft A, Jiang CC, Jin L, Zhang XD, Tseng H-Y, 'Sustained IRE1 and ATF6 signaling is important for survival of melanoma cells undergoing ER stress', CELLULAR SIGNALLING, 26 287-294 (2014) [C1]
DOI 10.1016/j.cellsig.2013.11.008
Citations Scopus - 17Web of Science - 11
Co-authors Xu Zhang, Lei Jin
2014 Chi M, Chen J, Ye Y, Tseng H-Y, Lai F, Tay KH, et al., 'Adipocytes Contribute to Resistance of Human Melanoma Cells to Chemotherapy and Targeted Therapy', CURRENT MEDICINAL CHEMISTRY, 21 1255-1267 (2014) [C1]
Citations Scopus - 7Web of Science - 5
Co-authors Lei Jin, Xu Zhang
2014 Dong L, Jin L, Tseng H-Y, Wang CY, Wilmott JS, Yosufi B, et al., 'Oncogenic suppression of PHLPP1 in human melanoma', ONCOGENE, 33 4756-4766 (2014) [C1]
DOI 10.1038/onc.2013.420
Citations Scopus - 4Web of Science - 2
Co-authors Xu Zhang, Lei Jin
2014 Jiang CC, Croft A, Tseng HY, Guo ST, Jin L, Hersey P, Zhang XD, 'Repression of microRNA-768-3p by MEK/ERK signalling contributes to enhanced mRNA translation in human melanoma', Oncogene, 33 2577-2588 (2014) [C1]

Increased global protein synthesis and selective translation of mRNAs encoding proteins contributing to malignancy is common in cancer cells. This is often associated with elevate... [more]

Increased global protein synthesis and selective translation of mRNAs encoding proteins contributing to malignancy is common in cancer cells. This is often associated with elevated expression of eukaryotic translation initiation factor 4 (eIF4E), the rate-limiting factor of cap-dependent translation initiation. We report here that in human melanoma downregulation of miR-768-3p as a result of activation of the mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) pathway has an important role in the upregulation of eIF4E and enhancement in protein synthesis. Melanoma cells displayed increased nascent protein production and elevated eIF4E expression, which was associated with the downregulation of miR-768-3p that was predicted to target the 3'-untranslated region of the eIF4E mRNA. Overexpression of miR-768-3p led to the downregulation of the endogenous eIF4E protein, reduction in nascent protein synthesis and inhibition of cell survival and proliferation. These effects were efficiently reversed when eIF4E was co-overexpressed in melanoma cells. On the other hand, introduction of anti-miR-768-3p into melanocytes upregulated endogenous eIF4E protein expression and increased global protein synthesis. Downregulation of miR-768-3p appeared to be mediated by activation of the MEK/ERK pathway, in that treatment of BRAF V600E melanoma cells with the mutant BRAF inhibitor PLX4720 or exposure of either BRAF V600E or wild-type BRAF melanoma cells to the MEK inhibitor U0126 resulted in the upregulation of miR-768-3p and inhibition of nascent protein synthesis. This inhibition was partially blocked in cells cointroduced with anti-miR-768-3p. Significantly, miR-768-3p was similarly downregulated, which was inversely associated with the expression levels of eIF4E in fresh melanoma isolates. Taken together, these results identify downregulation of miR-768-3p and subsequent upregulation of eIF4E as an important mechanism in addition to phosphorylation of eIF4E responsible for MEK/ERK-mediated enhancement of protein synthesis in melanoma. © 2014 Macmillan Publishers Limited.

DOI 10.1038/onc.2013.237
Citations Scopus - 10Web of Science - 6
Co-authors Lei Jin, Xu Zhang
2014 Liu Z, Zhang Y-Y, Zhang Q-W, Zhao S-R, Wu C-Z, Cheng X, et al., '3-Bromopyruvate induces apoptosis in breast cancer cells by downregulating Mcl-1 through the PI3K/Akt signaling pathway', ANTI-CANCER DRUGS, 25 447-455 (2014) [C1]
DOI 10.1097/CAD.0000000000000081
Citations Scopus - 12Web of Science - 8
2014 Zhang P, Liu H, Xia F, Zhang QW, Zhang YY, Zhao Q, et al., 'Epithelial-mesenchymal transition is necessary for acquired resistance to cisplatin and increases the metastatic potential of nasopharyngeal carcinoma cells', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 33 151-159 (2014) [C1]
DOI 10.3892/ijmm.2013.1538
Citations Scopus - 10Web of Science - 5
2014 Sun XJ, Zhang P, Li HH, Jiang ZW, Jiang CC, Liu H, 'Cisplatin combined with metformin inhibits migration and invasion of human nasopharyngeal carcinoma cells by regulating E-cadherin and MMP-9', Asian Pacific Journal of Cancer Prevention, 15 4019-4023 (2014) [C1]

Metformin has been shown to be useful in reducing insulin resistance by restoring sensitivity. Recent evidence suggests that metformin might also possess anti-tumour activity. Thi... [more]

Metformin has been shown to be useful in reducing insulin resistance by restoring sensitivity. Recent evidence suggests that metformin might also possess anti-tumour activity. This study aimed to investigate the effects of cisplatin combined with metformin on the proliferation, invasion and migration of HNE1/DDP human nasopharyngeal carcinoma (NPC) cells, and to provide a new target for treating metastasis. The MTT assay was used to assess viability of HNE1/DDP cells after exposure to different concentrations of 2, 5-diaminopyrimidine-4, 6-diol (DDP; 2, 4, 8, 16, and 32 µmol·L-1), metformin (5, 10, 15, 20, and 25 µmol·L-1), and 4 µmol·L-1 of DDP combined with metformin. Wound healing and transwell migration assays were performed to assess cell migration and invasion, and expression of E-cadherin and MMP-9 was detected using Western blotting. MTT assay results showed that DDP could inhibit the proliferation of HNE1/DDP cells in a time- and concentration-dependent manner, with an IC50 of 32.0 µmol·L-1 at 24 h (P < 0.05), whereas low concentrations of DDP had almost no inhibitory effects on cell invasion and migration. DDP combined with metformin significantly inhibited cell invasion and migration. In addition, genes related to migration and invasion, such as those of E-cadherin and MMP-9, showed differential expression in the NPC cell line HNE1/DDP. In the present study, with an increasing concentration of metformin, the expression of MMP-9 was downregulated whereas that of E-cadherin was significantly upregulated. Taken together, our results show that cisplatin combined with metformin has effects on proliferation, invasion, and migration of human NPC cells.

DOI 10.7314/APJCP.2014.15.9.4019
Citations Scopus - 10Web of Science - 3
2013 Wroblewski D, Jiang CC, Croft A, Farrelly ML, Zhang XD, Hersey P, 'OBATOCLAX and ABT-737 induce ER stress responses in human melanoma cells that limit induction of apoptosis.', PLoS One, 8 e84073 (2013) [C1]
DOI 10.1371/journal.pone.0084073
Citations Scopus - 9Web of Science - 5
Co-authors Xu Zhang
2013 Pu LJ, Liu H, Yang L, Huang YY, Xu JC, Zhang XD, et al., 'Knockdown GRP78 reverses resistance of human nasopharyngeal carcinoma to cisplatin-based chemotherapy and radiotherapy.', Asian Pac J Cancer Prev., 1003-1007 (2013)
2013 Tseng HY, Lai F, Jiang C, Kefford R, Long GV, Rizos H, Zhang XD, 'Inhibition of oncogenic BRAF triggers immunogenic cell death of human melanoma cells.', Journal Der Deutschen Dermatologieschen Gesellschaft, 257-259 (2013)
2013 Jin L, Dong L, Tseng HY, Wang CY, Wilmott JS, Yosufi B, et al., 'PHLPP1 deactivates Akt and has a tumor suppressive role in human melanoma.', Journal Der Deutschen Dermatologieschen Gesellschaft., 18-19 (2013)
2013 Xu J, Huang Y, Li Y, Pu L, Xia F, Jiang C, et al., 'Glycosylation inhibitor 2-deoxy-D-glucose sensitizes oral cancer cells to TRAIL-induced apoptosis.', Nan Fang Yi Ke Da Xue Xue Bao, 524-527 (2013)
2013 Zhang Y, Liu Z, Zhang Q, Chao Z, Zhang P, Xia F, et al., 'Effect of 3-bromopyruvate on mitochondrial membrane potential and apoptosis of human breast carcinoma SK-BR-3 cells', Nan Fang Yi Ke Da Xue Xue Bao, 1304-1307 (2013)
2013 Pu L, Huang Y, Li Y, Xu J, Jiang C, Liu H, Jiang Z, 'Inhibition of GRP78 sensitizes breast cancer cells to Cisplatin', Nan Fang Yi Ke Da Xue Xue Bao, 44-47 (2013)
2013 Xu J, Huang YY, Li Y, Pu LJ, Xia F, Jiang C, et al., 'Small interfering RNA-mediated RIP1 knockdown enhances L-OHP sensitivity of human oral squamous carcinoma cells', Nan Fang Yi Ke Da Xue Xue Bao, 1004-1007 (2013)
2013 Li Y, Liu H, Huang YY, Pu LJ, Zhang XD, Jiang ZW, Jiang C, 'Effects of cisplatin combined with heparanase inhibitor on proliferation and invasion of human nasopharyngeal carcinoma cells', Yao Xue Xue Bao, 609-614 (2013)
2013 Huang YY, Liu H, Li Y, Pu LJ, Jiang CC, Xu JC, Jiang ZW, 'Down-regulation of RIP1 by 2-deoxy-D-glucose sensitizes breast cancer cells to TRAIL-induced apoptosis', European Journal of Pharmacology, 705 26-34 (2013) [C1]
DOI 10.1016/j.ejphar.2013.02.005
Citations Scopus - 3Web of Science - 3
2013 Zhao SR, Duan HF, Zhang P, Liu H, Jiang C, Jiang ZW, '2-DG enhances TRAIL-induced apoptosis of leukemia HL-60 cells', Zhongguo Shi Yan Xue Ye Xue Za Zhi, 351-355 (2013)
2013 Guo ST, Jiang CC, Wang GP, Li YP, Wang CY, Guo XY, et al., 'MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer', ONCOGENE, 32 1910-1920 (2013) [C1]
DOI 10.1038/onc.2012.214
Citations Scopus - 80Web of Science - 44
Co-authors Lei Jin, Rick Thorne, Xu Zhang
2013 Li Y, Liu H, Huang YY, Pu LJ, Zhang XD, Jiang CC, Jiang ZW, 'Suppression of endoplasmic reticulum stress-induced invasion and migration of breast cancer cells through the downregulation of heparanase', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE, 31 1234-1242 (2013) [C1]
DOI 10.3892/ijmm.2013.1292
Citations Scopus - 13Web of Science - 8
Co-authors Xu Zhang
2013 Sun X-J, Liu H, Zhang P, Zhang X-D, Jiang Z-W, Jiang C-C, 'miR-10b Promotes Migration and Invasion in Nasopharyngeal Carcinoma Cells', ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 14 5533-5537 (2013) [C1]
DOI 10.7314/APJCP.2013.14.9.5533
Citations Scopus - 24Web of Science - 16
Co-authors Xu Zhang
2013 Song L, Liu H, Ma L, Zhang X, Jiang Z, Jiang C, 'Inhibition of autophagy by 3-MA enhances endoplasmic reticulum stress-induced apoptosis in human nasopharyngeal carcinoma cells', ONCOLOGY LETTERS, 6 1031-1038 (2013) [C1]
DOI 10.3892/ol.2013.1498
Citations Scopus - 5Web of Science - 4
Co-authors Xu Zhang
2013 Ye Y, Jin L, Wilmott JS, Hu WL, Yosufi B, Thorne RF, et al., 'PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma', NATURE COMMUNICATIONS, 4 (2013) [C1]
DOI 10.1038/ncomms2489
Citations Scopus - 30Web of Science - 19
Co-authors Xu Zhang, Rick Thorne, Lei Jin
2013 Lai F, Guo ST, Jin L, Jiang CC, Wang CY, Croft A, et al., 'Cotargeting histone deacetylases and oncogenic BRAF synergistically kills human melanoma cells by necrosis independently of RIPK1 and RIPK3', CELL DEATH & DISEASE, 4 (2013) [C1]
DOI 10.1038/cddis.2013.192
Citations Scopus - 16Web of Science - 10
Co-authors Lei Jin, Xu Zhang
2013 Hu W, Jin L, Jiang CC, Long GV, Scolyer RA, Wu Q, et al., 'AEBP1 upregulation confers acquired resistance to BRAF (V600E) inhibition in melanoma.', Cell Death and Disease, 4 e914 (2013) [C1]
DOI 10.1038/cddis.2013.441
Citations Scopus - 9Web of Science - 8
Co-authors Lei Jin, Xu Zhang
2012 Song L, Ma L, Zhang X, Jiang Z, Liu H, Jiang C, 'Effect of tunicamycin combined with cisplatin on the proliferation and apoptosis of human nasopharyngeal carcinoma cells.', Nan Fang Yi Ke Da Xue Xue Bao, 766-771 (2012)
2012 Zhang P, Zhao S, Song L, Pu L, Jiang Z, Liu H, Jiang C, 'Effect of low molecular weight heparin combined with taxol on invasion and migration of nasopharyngeal carcinoma cells.', Nan Fang Yi Ke Da Xue Xue Bao, 1529-1535 (2012)
2012 Tseng HY, Chen L, Ye Y, Tay KH, Jiang CC, Guo ST, et al., 'The melanoma-associated antigen MAGE-D2 suppresses TRAIL receptor 2 and protects against TRAIL-induced apoptosis in human melanoma cells', Carcinogenesis, 33 1871-1881 (2012) [C1]
Citations Scopus - 7Web of Science - 4
Co-authors Xu Zhang, Lei Jin
2012 Lai FS, Jiang CC, Farrelly ML, Zhang XD, Hersey P, 'Evidence for upregulation of Bim and the splicing factor SRp55 in melanoma cells from patients treated with selective BRAF inhibitors', Melanoma Research, 22 244-251 (2012) [C1]
Citations Scopus - 14Web of Science - 12
Co-authors Xu Zhang
2012 Tay KH, Jin L, Tseng HY, Jiang CC, Ye Y, Thorne RF, et al., 'Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress', Cell Death and Disease, 3 e337 (2012) [C1]
Citations Scopus - 18Web of Science - 16
Co-authors Nikki Verrills, Xu Zhang, Rick Thorne, Lei Jin
2011 Jiang CC, Lai F, Thorne RF, Yang F, Liu H, Hersey P, Zhang XD, 'MEK-independent survival of B-RAFV600E melanoma cells selected for resistance to apoptosis induced by the RAF inhibitor PLX4720', Clinical Cancer Research, 17 721-730 (2011) [C1]
Citations Scopus - 63Web of Science - 57
Co-authors Rick Thorne, Xu Zhang
2011 Jin L, Hu WL, Jiang CC, Wang JX, Han CC, Chu P, et al., 'MicroRNA-149*, a p53-responsive microRNA, functions as an oncogenic regulator in human melanoma', Proceedings of the National Academy of Sciences, 108 15840-15845 (2011) [C1]
Citations Scopus - 77Web of Science - 64
Co-authors Lei Jin, Rick Thorne, Xu Zhang
2011 Dong L, Jiang CC, Thorne RF, Croft A, Yang F, Liu H, et al., 'Ets-1 mediates upregulation of Mcl-1 downstream of XBP-1 in human melanoma cells upon ER stress', Oncogene, 30 3716-3726 (2011) [C1]
DOI 10.1038/onc.2011.87
Citations Scopus - 33Web of Science - 31
Co-authors Xu Zhang, Rick Thorne
2010 Jiang CC, Lai F, Tay KH, Croft A, Rizos H, Becker TM, et al., 'Apoptosis of human melanoma cells induced by inhibition of B-RAF(V600E) involves preferential splicing of bim(S)', Cell Death & Disease, 1 e69 (2010) [C1]
DOI 10.1038/cddis.2010.48
Citations Scopus - 55Web of Science - 50
Co-authors Rick Thorne, Xu Zhang
2010 Tseng HY, Jiang C, Croft A, Tay KH, Throng RF, Yang F, et al., 'Contrasting Effects of Nutlin-3 on TRAIL- and Docetaxel-Induced Apoptosis Due to Upregulation of TRAIL-R2 and Mcl-1 in Human Melanoma Cells', Mol Cancer Ther, 3363-3374 (2010)
2010 Yang F, Tay KH, Dong L, Thorne RF, Jiang CC, Yang E, et al., 'Cystatin B inhibition of TRAIL-induced apoptosis is associated with the protection of FLIPL from degradation by the E3 ligase itch in human melanoma cells', Cell Death and Differentiation, 17 1354-1367 (2010) [C1]
DOI 10.1038/cdd.2010.29
Citations Scopus - 32Web of Science - 28
Co-authors Xu Zhang, Rick Thorne
2010 Mao ZG, Jiang CC, Thorne RF, Hersey P, Zhang XD, 'TRAIL-induced apoptosis of human melanoma cells involves activation of caspase-4', Apoptosis, 15 1211-1222 (2010) [C1]
DOI 10.1007/s10495-010-0513-9
Citations Scopus - 16Web of Science - 11
Co-authors Xu Zhang, Rick Thorne
2009 Liu H, Jiang CC, Lavis CJ, Croft A, Dong L, Tseng H-Y, et al., '2-Deoxy-D-glucose enhances TRAIL-induced apoptosis in human melanoma cells through XBP-1-mediated up-regulation of TRAIL-R2', Molecular Cancer, 8 Article no. 122 (2009) [C1]
DOI 10.1186/1476-4598-8-122
Citations Scopus - 34Web of Science - 24
Co-authors Xu Zhang
2009 Jiang CC, Yang F, Thorne RF, Zhu BK, Hersey P, Zhang XD, 'Human melanoma cells under endoplasmic reticulum stress acquire resistance to microtubule-targeting drugs through XBP-1-mediated activation of Akt', Neoplasia, 11 436-447 (2009) [C1]
DOI 10.1593/neo.09208
Citations Scopus - 33Web of Science - 28
Co-authors Rick Thorne, Xu Zhang
2009 Jiang CC, Wroblewski D, Yang F, Hersey P, Zhang XD, 'Human melanoma cells under endoplasmic reticulum stress are more susceptible to apoptosis induced by the BH3 mimetic obatoclax', Neoplasia, 11 945-955 (2009) [C1]
DOI 10.1593/neo.09692
Citations Scopus - 33Web of Science - 27
Co-authors Xu Zhang
2009 Jiang CC, Mao ZG, Kiejda KA, Hersey P, Zhang XD, 'Glucose-regulated protein 78 antagonizes cisplatin and adriamycin in human melanoma cells', Carcinogenesis, 30 197-204 (2009) [C1]
DOI 10.1093/carcin/bgn220
Citations Scopus - 51Web of Science - 45
Co-authors Kelly Kiejda, Xu Zhang
2008 Zhang XD, Jiang C, Kiejda KA, Lucas K, Wade M, Allen J, Hersey P, 'Up-regulation of Mcl-1 by the unfolded protein response is critical for survival of melanoma cells upon ER stress.', Pigment Cell Melanoma Res., 257-277 (2008)
2008 Chen LH, Jiang CC, Watts R, Thorne RF, Kiejda KA, Zhang XD, Hersey P, 'Inhibition of endoplasmic reticulum stress-induced apoptosis of melanoma cells by the ARC protein', Cancer Research, 68 834-842 (2008) [C1]
DOI 10.1158/0008-5472.can-07-5056
Citations Scopus - 30Web of Science - 24
Co-authors Xu Zhang, Kelly Kiejda, Rick Thorne
2008 Jiang CC, Lucas K, Kiejda KA, Wade M, Debock CE, Thorne RF, et al., 'Up-regulation of Mcl-1 is critical for survival of human melanoma cells upon endoplasmic reticulum stress', Cancer Research, 68 6708-6717 (2008) [C1]
DOI 10.1158/0008-5472.can-08-0349
Citations Scopus - 81Web of Science - 73
Co-authors Rick Thorne, Kelly Kiejda, Xu Zhang
2008 Zhu B-K, Wang P, Zhang XD, Jiang CC, Chen LH, Kiejda KA, et al., 'Activation of Jun N-terminal kinase is a mediator of vincristine-induced apoptosis of melanoma cells', Anti-Cancer Drugs, 19 189-200 (2008) [C1]
DOI 10.1097/CAD.0b013e3282f3138a
Citations Scopus - 24Web of Science - 22
Co-authors Xu Zhang, Kelly Kiejda
2007 Mhaidat NM, Zhang XD, Jiang CC, Hersey P, 'Docetaxel-induced apoptosis of human melanoma is mediated by activation of c-Jun NH2-terminal kinase and inhibited by the mitogen-activated protein kinase extracellular signal-regulated kinase 1/2 pathway', Clinical Cancer Research, 13 1308-1314 (2007) [C1]
DOI 10.1158/1078-0432.ccr-06-2216
Citations Scopus - 52Web of Science - 45
Co-authors Xu Zhang
2007 Yu FW, Jiang CC, Kiejda KA, Gillespie S, Zhang XD, Hersey P, 'Apoptosis induction in human melanoma cells by inhibition of MEK is caspase-independent and mediated by the Bcl-2 family members PUMA, Bim, and Mcl-1', Clinical Cancer Research, 13 4934-4942 (2007) [C1]
DOI 10.1158/1078-0432.CCR-07-0665
Citations Scopus - 107Web of Science - 110
Co-authors Xu Zhang, Kelly Kiejda
2007 Hersey P, Zhang XD, Jiang C, 'Endoplasmic stress (ER) in melanoma cells.', Arch Dermatol Res., 289-299 (2007)
2007 Jiang CC, Li HC, Gillespie S, Kiejda KA, Mhaidat N, Yu FW, et al., 'Tunicamycin sensitizes human melanoma cells to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis by up-regulation of TRAIL-R2 via the unfolded protein response', Cancer Research, 67 5880-5888 (2007) [C1]
DOI 10.1158/0008-5472.CAN-07-0213
Citations Scopus - 70Web of Science - 65
Co-authors Kelly Kiejda, Xu Zhang, Rick Thorne
2007 Jiang CC, Li HC, Gillespie S, Yu FW, Kiejda KA, Zhang XD, Hersey P, 'Inhibition of MEK sensitizes human melanoma cells to endoplasmic reticulum stress-induced apoptosis', Cancer Research, 67 9750-9761 (2007) [C1]
DOI 10.1158/0008-5472.CAN-07-2047
Citations Scopus - 90Web of Science - 78
Co-authors Xu Zhang, Kelly Kiejda
2007 Chen LH, Jiang CC, Kiejda KA, Wang YF, Thorne RF, Zhang XD, Hersey P, 'Thapsigargin sensitizes human melanoma cells to TRAIL-induced apoptosis by up-regulation of TRAIL-R2 through the unfolded protein response', Carcinogenesis, 28 2328-2336 (2007) [C1]
DOI 10.1093/carcin/bgm173
Citations Scopus - 31Web of Science - 26
Co-authors Rick Thorne, Kelly Kiejda, Xu Zhang
Show 67 more journal articles

Conference (93 outputs)

Year Citation Altmetrics Link
2015 Jiang CC, Chi MN, Guo ST, Wilmott JS, Guo XY, Yan XG, et al., 'Inositol polyphosphate 4-phosphatase II activates PI3K/SGK3 signaling to promote proliferation of human melanoma cells', CANCER RESEARCH (2015) [E3]
DOI 10.1158/1538-7445.AM2015-4718
Co-authors Lei Jin, Xu Zhang, Hubert Hondermarck
2015 Jiang C, Chi MN, Zhang XD, 'MicroRNA regulation of INPP4B to promote melanoma cell proliferation through PI3K/SGK3.', 107th AACR Annual Meeting 2015, (2015) [O1]
2015 Jin L, Liu XY, Lai F, Yan XG, Jiang C, Guo ST, et al., 'Receptor-Interacting Protein Kinase 1 Functions as an oncogenic regulator in human melanoma', Cancer Research (2015) [E3]
Co-authors Xu Zhang, Lei Jin
2015 Wang CY, Jiang C, Zhang XD, 'Targeting MEK.ERK and PI3K/Akt to overcome resistance of human colon cancer to HSP90 inhibitor.', 27th Lorne Cancer Conference (2015) [O1]
2015 Jin L, Liu XY, Yan XG, Jiang C, Guo ST, Wang CY, et al., 'Receptor-Interacting Protein Kinase 1 Functions as an oncogenic regulator in human melanoma.', 27th Lorne Cancer Conference (2015) [O1]
2015 Guo ST, Chi M, Rang RH, Cuo XY, Wang CY, Zan LQ, et al., 'Inositol polyphosphate 4-phosphatase II promotes PI3K signaling and functions as an oncogenic regulator in human colon cancer', 27th Lorne Cancer Conference (2015) [E3]
2015 Jiang C, Chi MN, Zhang XD, 'MicroRNA regulation of INPP4B to promote melanoma cell proliferation through PI3K/SGK3', 27th Lorne Cancer Conference (2015) [E3]
2015 Wang JU, Wang CY, Jiang C, Tseng HY, Guo ST, Jin L, Zhang XD, 'Regulation of sensitivity of human melanoma cells to killing by the human Mut T homolog1 inhibitor.', 27th Lorne Cancer Conference (2015) [O1]
2015 Tseng HY, Luan Q, Jin L, Jiang C, Tay KH, Lai F, et al., 'Receptor-Interacting Protein Kinase 1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy.', 27th Lorne Cancer Conference (2015) [O1]
2015 Yan XG, Luan Q, Jin L, Jiang CC, Tay KH, Lai F, et al., 'Receptor-interacting protein kinase 1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy', CANCER RESEARCH (2015) [E3]
DOI 10.1158/1538-7445.AM2015-1029
Co-authors Xu Zhang, Lei Jin
2015 Liu XY, Lai F, Yan XG, Jiang CC, Guo ST, Wang CY, et al., 'RIP1 kinase is an oncogenic driver in melanoma', INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2015) [E3]
Co-authors Lei Jin, Xu Zhang
2014 Jin L, Liu XY, Lai F, Yan XG, Jiang C, Guo ST, et al., 'Receptor-Interacting Protein Kinase 1 Functions as an oncogenic regulator in human melanoma.', Hunter Cancer Research Symposium (2014) [E3]
Co-authors Xu Zhang, Lei Jin
2014 Tseng HY, Luan Q, Jin L, Jiang C, Tay KH, Lai F, et al., 'Receptor-Interacting Protein Kinase 1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy', Hunter Cancer Research Symposium (2014) [E3]
Co-authors Lei Jin, Xu Zhang
2014 Jiang C, Chi MN, Guo ST, Wilmott JS, Guo XG, Yan XG, et al., 'MicroRNA regulation of inositol polyphosphate 4-phosphatase II to modulate melanocytic cell proliferation through PI3K/SGK3 signaling', Hunter Cancer Research Symposium (2014) [E3]
Co-authors Xu Zhang
2014 Chi MN, Chen J, Ye Y, Tseng HY, Lai F, Tay KH, et al., 'Adipocytes contribute to resistance of human melanoma cells to chemotherapy and targeted therapy.', The Australian Society for Medical Research (ASMR) Satellite Scientific Meeting (2014) [E3]
Co-authors Lei Jin, Xu Zhang
2014 Wang CY, Jiang C, Chi MN, Croft A, Guo ST, Zhang XD, 'Reactivation of Akt and ERK protects against HSP90 inhibitors in human colon cancer cells.', The Australian Society for Medical Research (ASMR) Satellite Scientific Meeting. (2014) [E3]
Co-authors Xu Zhang
2014 Lai F, Guo ST, Jin L, Jiang C, Wang CY, Croft A, et al., 'Cotargeting histone deacetylases and oncogenic BRAF synergistically kills melanoma cells by necrosis independently of RIPK1 and RIPK3.', The Australian Society for Medical Research (ASMR) Satellite Scientific Meeting. (2014) [E3]
Co-authors Lei Jin, Xu Zhang
2014 Wang CY, Jiang CC, Guo ST, Croft A, Jin L, Tseng H-Y, et al., 'TARGETING MEK/ERK AND PI3K/AKT TO OVERCOME RESISTANCE OF HUMAN COLON CANCER TO HSP90 INHIBITORS', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
Co-authors Lei Jin, Xu Zhang
2014 Croft A, Tay KH, Philipsz S, Jiang CC, Lai F, Tseng H-Y, et al., 'ONCOGENIC ACTIVATION OF MEK/ERK PRIMES MELANOMA CELLS FOR ADAPTATION TO ENDOPLASMIC RETICULUM STRESS', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
Co-authors Xu Zhang, Lei Jin
2014 Guo ST, Chi MN, Yang RH, Guo XY, Wang CY, Zan LQ, et al., 'INOSITOL POLYPHOSPHATE 4-PHOSPHATASE II PROMOTES PI3K SIGNALING AND FUNCTIONS AS AN ONCOGENIC REGULATOR IN HUMAN COLON CANCER', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
Co-authors Xu Zhang, Rodney Scott, Rick Thorne, Stephen Ackland, Lei Jin
2014 Wang JY, Wang CY, Jiang CC, Tseng H-Y, Guo ST, Jin L, Zhang XD, 'REGULATION OF SENSITIVITY OF HUMAN MELANOMA CELLS TO KILLING BY THE HUMAN MUT T HOMOLOG1 INHIBITOR', ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY (2014) [E3]
Co-authors Xu Zhang, Lei Jin
2013 Guo ST, Lal F, Jiang CC, Wang CY, Farrelly M, Tseng H-Y, et al., 'Co-targeting histone deacetylases and oncogenic BRAF synergistically kills human melanoma cell by caspase-independent cell death.', CANCER RESEARCH (2013) [E3]
DOI 10.1158/1538-7445.AM2013-2028
Co-authors Xu Zhang
2013 Tay KH, Tseng HY, Jiang C, Ye Y, Throne RF, Liu P, et al., 'PP2A signalling is overridden by MEK/ERK activity leading to suppression of Bim and progection of melanoma cells upon ER stress.', 103st Annual Meeting of American Association for Cancer Research (2013)
2013 Tseng HY, Chen LH, Ye Y, Tay KH, Jiang C, Hersey P, Zhang XD, 'The cancer testis antigen MAGE-D2 protects human melanoma cells from TRAIL-induced apoptosis by suppressing TRAIL-R2 expression.', 103st Annual Meeting of American Association for Cancer Research (2013)
2013 Jiang C, Zhang XD, 'Inhibition of oncogenic BRAF triggers immunogenic necrosis of human melanoma cells.', 8th World Congress of Melanoma (2013)
2013 Zhang XD, Jiang C, 'PHLPP1 deactivates Akt and has a tumor suppressive role in human melanoma.', 8th World Congress of Melanoma (2013)
2013 Croft A, Tay KH, Philipse S, Jiang C, Lai F, Tseng HY, Zhang XD, 'Oncogenic activation of MEK/ERK primes melanoma cells for adaptation to endoplasmic reticulum stress', HCRA Translational Cancer Research Conference (2013)
2013 Jiang C, Zhang XD, 'To keep PI3K/Akt in check in melanoma: more than just PTEN.', HCRA Translational Cancer Research Conference (2013)
2013 Jiang C, Chi MN, Chen JZ, Ye Y, 'Adipocytes contribute to resistance of human melanoma cells to chemotherapy and targeted therapy', HCRA Translational Cancer Research Conference. (2013)
2013 Jiang C, Croft A, Tseng HY, Jin L, Hersey P, Zhang XD, 'Repression of microRNA-768-3p by MEK/ERK signalling contributes to enhanced mRNA translation in human melanoma.', HCRA Translational Cancer Research Conference. (2013)
2013 Liu YL, Lai F, Jiang C, Tseng HY, Jin L, Zhang XD, 'Noxa induced by oncogenic activation of MEK/ERK regulates autophagy in human melanoma.', HCRA Translational Cancer Research Conference. (2013)
2013 Jin L, Dong L, Tseng HY, Wang CY, Wilmott JS, Yan XG, et al., 'Oncogenic suppression of PHLPP in human melanoma.', HCRA Translational Cancer Research Conference. (2013)
2013 Wang CY, Jiang C, Tseng HY, Zhang XD, 'MicroRNA-497 targets insulin-like growth factor 1 receptor and has a tumour suppressive role in human colorectal cancer.', HCRA Translational Cancer Research Conference. (2013)
2013 Liu XY, Lai F, Jiang C, Tseng HY, Jin L, Zhang XD, 'RIPK1 inhibition of killing by BRAF inhibitors in melanoma cells.', HCRA Translational Cancer Research Conference. (2013)
2013 Tseng H-Y, Lai F, Jin L, Jiang CC, Kefford R, Long G, et al., 'Inhibition of Oncogenic BRAF Triggers Immunogenic Necrosis of Human Melanoma Cells', JOURNAL DER DEUTSCHEN DERMATOLOGISCHEN GESELLSCHAFT (2013) [E3]
Co-authors Xu Zhang, Lei Jin
2013 Liu H, Zhang Y-Y, Zhang Q-W, Chao Z-H, Zhang P, Jiang C-C, Jiang Z-W, '3-bromopyruvate induces necroptosis and autophagy in breast cancer cell lines', ACTA PHARMACOLOGICA SINICA (2013) [E3]
2012 Lai F, Jiang C, Hersey P, Zhang XD, 'Targeting histone deacetylases - a promising approach to improve therapeutic efficacy of mutant BRAF inhibitors in melanoma.', 24th Lorne Cancer Conference (2012)
2012 Tseng HY, Chen LH, Ye Y, Tay KH, Jiang C, Hersey P, Zhang XD, 'The cancer testis antigen MAGED2 protects human melanoma cells from TRAIL-induced apoptosis by suppressing TRAIL-R2 expression.', 24th Lorne Cancer Conference (2012)
2012 Jiang C, Guo ST, Wang GP, Tseng HY, Throne RF, Jin L, Zhang XD, 'MicroRNA-497 targets Insulin-like growth factor 1 receptor and has a tumor suppressive role in human colorectal cancer.', 6th Garvan Signaling Symposium (2012)
2012 Tay KH, Jin L, Tseng HY, Jiang C, Ye Y, Throne RF, et al., 'Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress.', 6th Garvan Signaling Symposium (2012)
2012 Ye Y, Jin L, Wilmott JS, Hu WL, Yosufi B, Throne RF, et al., 'PI(4,5)P2 5-phosphatase A regulates PI3K/Akt signalling and has a tumour suppressive role in human melanoma.', Inaugural Melanoma Conference 2012 (2012)
2011 Ye Y, Jin L, Wilmott J, Hu WL, Thorne RF, Dong L, et al., 'Phosphatidylinositol 4,5-Bisphosphate 5-Phosphatase A regulates PI3K/Akt signaling in human melanoma cells', Pigment Cell & Melanoma Research (2011) [E3]
DOI 10.1111/j.1755-148X.2011.00909.x
Co-authors Xu Zhang, Rick Thorne
2011 Hersey P, Wroblewski DJR, Lai FS, Jiang CC, Zhang XD, 'Targeting anti-apoptotic mechanisms for reversal of resistance to BRAF inhibitors in melanoma', Pigment Cell & Melanoma Research (2011) [E3]
DOI 10.1111/j.1755-148X.2011.00909.x
Co-authors Xu Zhang
2011 Ye Y, Dong L, Jiang C, Hersey P, Zhang XD, 'Epigenetic repression of the inoditol polyphosphate 5-Phosphatase PIPP contributes to activation of AKT and resistance to apoptosis in human melanoma.', 23rd Lorne Cancer Conference (2011)
2011 Tseng HY, Jiang C, Croft A, Tay KH, Throne RF, Yang F, et al., 'P53 functions as a double-edged sword for response of human melanoma to treatment.', 23rd Lorne Cancer Conference (2011)
2011 Wroblewski D, Jiang C, Croft A, Hersey P, Zhang XD, 'Activation of the unfolded protein response protects human melanoma cells against apoptosis induced by Obatoclax and ABT-737.', 23rd Lorne Cancer Conference (2011)
2011 Croft A, Lai F, Jiang C, Hersey P, Zhang XD, 'Active XBP1 levels may predict resistance of B-RAF V600E melanoma cell lines to PLX4720', 23rd Lorne Cancer Conference (2011)
2011 Tay KH, Jiang C, Tseng HY, Hersey P, Zhang XD, 'Dysregulation of the CHOP-Bim pathway contributes to resistance of melanoma cells to ER stress-induced apoptosis.', 23rd Lorne Cancer Conference (2011)
2010 Dong L, Jiang CC, Thorne RF, Yang F, Liu H, De Bock CE, et al., 'Transcriptional up-regulation of Mcl-1 by ETS1 down-stream of XBP-1 in melanoma cells upon ER stress', Pigment Cell & Melanoma Research (2010) [E3]
Co-authors Rick Thorne, Xu Zhang
2010 Chen LH, Yang F, Tay KH, Dong L, Thorne RF, Jiang CC, et al., 'Cystatin B inhibition of TRAIL-induced apoptosis is associated with protection of FLIPLfrom degradation by the E3 ligase itch human melanoma cells', Pigment Cell & Melanoma Research (2010) [E3]
DOI 10.1038/cdd.2010.29
Co-authors Rick Thorne, Xu Zhang
2010 Yang XM, Chen LH, Jiang CC, De Bock CE, Thorne RF, Hersey P, Zhang XD, '40p53 is up-regulated and plays a role in antagonizing p53-mediated apoptosis in human melanoma', Pigment Cell & Melanoma Research (2010) [E3]
Co-authors Xu Zhang, Rick Thorne
2010 Zhang XD, Jiang CC, Lai F, Croft A, Tay KH, Thorne RF, et al., 'Apoptotic response of mutant B-RAF human melanoma cells to a B-RAF inhibitor involves increased splicing production of BimS', AACR 101st Annual Meeting 2010. Abstracts (2010) [E3]
Co-authors Rick Thorne, Xu Zhang
2010 Jiang CC, Zhuang LQ, Dong L, Thorne RF, Lavis CJ, Hersey P, Zhang XD, 'Adaptation to ER stress as a driver of increased expression of Mcl-1 with melanoma progression', AACR 101st Annual Meeting 2010. Abstracts (2010) [E3]
Co-authors Rick Thorne, Xu Zhang
2010 Zhang XD, Jiang CC, Zhuang LQ, Hersey P, 'Adaptation to ER stress as a mechanism of resistance of melanoma to treatment', Melanoma 2010 Congress. Oral and Poster Abstracts (2010) [E3]
Co-authors Xu Zhang
2010 Croft A, Lai F, Jiang CC, Zhang XD, Hersey P, 'Active XBP1 levels may predict resistance of B-Raf V600E melanoma cell lines to PLX4720', Melanoma 2010 Congress. Oral and Poster Abstracts (2010) [E3]
Co-authors Xu Zhang
2010 Jiang CC, Lai FS, Hersey P, Zhang XD, 'Preferential splicing of BimS plays a predominant role in induction of apoptosis in human melanoma cells', Melanoma 2010 Congress. Oral and Poster Abstracts (2010) [E3]
Co-authors Xu Zhang
2010 Lai F, Jiang CC, Hersey P, Zhang XD, 'Long-term exposure to the B-RAFV600E inhibitor PLX4720 results in melanoma cells with increased activation of ERK1/2 and high proliferation potential', Melanoma 2010 Congress. Oral and Poster Abstracts (2010) [E3]
Co-authors Xu Zhang
2010 Tseng HY, Jiang CC, Croft A, Tay KH, Yang F, Liu H, et al., 'Contrasting effects of nutlin-3 on TRAIL- and docetaxel-induced apoptosis in human melanoma cells', Melanoma 2010 Congress. Oral and Poster Abstracts (2010) [E3]
DOI 10.1158/1535-7163.MCT-10-0646
Citations Scopus - 19Web of Science - 18
Co-authors Xu Zhang, Rick Thorne
2010 Tay KH, Jiang CC, Tseng HY, Hersey P, Zhang XD, 'Rapid negative feedback regulation of CHOP contributes to resistance of melanoma cells to ER stress-induced apoptosis', Melanoma 2010 Congress. Oral and Poster Abstracts (2010) [E3]
Co-authors Xu Zhang
2010 Zhang XD, Jiang C, Croft A, Lai F, Tay KH, Throne R, et al., 'Apoptosis response of mutant BRAF human melanoma cells to a BRAF inhibitor involves increased splicing production of BimS.', 101st Annual Meeting of American Association for Cancer Research (2010)
2010 Jiang C, Zhang XD, Lucas K, Allen J, hersey P, 'Adaptation to ER stress as a driver of increased expression of Mcl-1 with melanoma progression', 101st Annual Meeting of American Association for Cancer Research, (2010)
2010 Zhang XD, Jiang C, Hersey P, 'Towards targeting adaptive mechanisms to ER stress in human melanoma', 22nd Lorne Cancer Conference (2010)
2010 Lai F, Jiang C, Zhang XD, Hersey P, 'Human Melanoma Cells under Endoplasmic Reticulum Stress Are More Susceptible to Apoptosis Induced by the BH3 Mimetic Obatoclax,', 22nd Lorne Cancer Conference (2010)
2010 Jiang C, Lai F, Hersey P, Zhang XD, 'Long-term exposure to the BRAFV600E inhibitor PLX4720 results in melanoma cells with increased activation of ERK1/2 and high proliferation potential.', 7th International Congress of the Society of melanoma research (2010)
2010 Zhang XD, Jiang C, Lai F, Croft A, Tay KH, Throne RF, et al., 'Apoptosis response of mutant B-RAF human melanoma cells to a B-RAF inhibitor involves increased splicing production of BimS.', Cold Spring Harbor James Watson Cancer Symposium (2010)
2009 Kiejda KA, Scurr LL, Wade MA, Jiang CC, Weir AJW, Bowden NA, et al., 'Cisplatin induces apoptosis independently of Noxa or PUMA in human melanoma cells', 21st Lorne Cancer Conference (2009) [E3]
Co-authors Kelly Kiejda, Nikola Bowden, Xu Zhang, Rodney Scott
2009 Zhang XD, Jiang C, Throne RF, Lucas K, Allen J, Hersey P, 'Up-regulation of Mcl-1 via XBP1-mediated Akt activation is critical for survival of melanoma cells upon ER Stress.', 100th Annual Meeting of American Association for Cancer Research (2009)
2009 Wroblewski D, Jiang C, Mao ZG, Zhang XD, Hersey P, 'Multiple mechanisms are responsible for killing of human melanoma cells by the BH3 mimetic Obatoclax', 21st Lorne Cancer Conference (2009)
2009 Yang F, Jiang C, Yang E, Christopherson R, Crossett B, Elias R, Hersey P, 'Cystatin B protects human melanoma cells against TRAIL-induced apoptosis by inhibiting activation of Caspase-8.', 21st Lorne Cancer Conference (2009)
2009 Jiang C, Zhang XD, Hersey P, 'XBP1 up-regulates Mcl-1 via activation of AKT in human melanoma cells under ER stress.', 21st Lorne Cancer Conference (2009)
2009 Weir AJW, Jiang C, Mao Z, Throne RF, Zhu B, Hersey P, Zhang XD, 'Human melanoma cells under Endoplasmic Reticulum stress acquire resistance to microtubule-targeting drugs.', 21st Lorne Cancer Conference (2009)
2009 Zhang XD, Jiang C, Chen LH, Hersey P, 'Towards targeting adaptive mechanisms of ER stress in human melanoma.', 21st Lorne Cancer Conference. (2009)
2009 Lavis C, Jiang C, Zhang XD, Hersey P, 'CHOP mediated apoptotic signalling is non-functional in melanoma under Endoplasmic Reticulum Stress.', 21st Lorne Cancer Conference. (2009)
2008 Zhang XD, Jiang CC, Avery-Kiejda KA, Lucas K, Wade M, Allen J, Hersey P, 'Up-regulation of Mcl-1 by the unfolded protein response is critical for survival of melanoma cells upon ER stress', PIGMENT CELL & MELANOMA RESEARCH (2008) [E3]
Co-authors Xu Zhang, Kelly Kiejda
2008 Jiang CC, Wade MA, Kiejda KA, Wang Y, Zhang XD, Hersey P, 'Up-regulation of MCL-1 is critical for survival of human melanoma cells upon ER stress', 20th Lorne Cancer Conference (2008) [E3]
Co-authors Xu Zhang, Kelly Kiejda
2008 Zhang XD, Jiang CC, Wang YF, Kiejda KA, Hersey P, 'The MEK/ERK pathway potentiates adaptation of human melanoma to endoplasmic reticulum stress', 20th Lorne Cancer Conference (2008) [E3]
Co-authors Kelly Kiejda, Xu Zhang
2008 Zhang XD, Jiang C, Chen LH, Kiejda KA, Wade M, Hersey P, 'Multiple apoptosis pathways are inhibited in human melanoma cells upon ER stress.', 16th Euroconference on Apoptosis (2008)
2008 Jiang C, Zhang XD, Wang YF, Kiejda KA, Hersey P, 'The MEK/ERK Pathway Potentiates Adaptation of Human Melanoma to Endoplasmic Reticulum Stress', 20th Lorne Cancer Conference (2008)
2008 Jiang C, Wang YF, Kiejda KA, Zhang XD, Hersey P, 'The MEK/ERK pathway potentiates adaptation of human melanoma to endoplasmic reticulum stress.', 99th Annual Meeting of American Association for Cancer Research (2008)
2008 Zhang XD, Jiang C, Wang YF, Wade M, Kiejda KA, Hersey P, 'The unfolded protein response differentially regulates sensitivities of human melanoma cells to chemotherapeutic drugs.', 99th Annual Meeting of American Association for Cancer Research (2008)
2008 Lavis C, Jiang C, Zhang XD, Hersey P, 'CHOP mediated apoptotic signalling is non-functional in melanoma under Endoplasmic Reticulum Stress.', HMRI Conference on Translational Cancer Research (2008)
2008 Wroblewski D, Jiang C, Mao ZG, Zhang XD, Hersey P, 'Multiple mechanisms are responsible for killing of human melanoma cells by the BH3 mimetic Obatoclax.', HMRI Conference on Translational Cancer Research (2008)
2008 Jiang C, Zhang XD, Hersey P, 'The MEK/ERK pathway potentiates adaptation of human melanoma to endoplasmic reticulum stress', HMRI Conference on Translational Cancer Research (2008)
2007 Hersey P, Zhang XD, Jiang CC, Chen LH, 'Endoplasmic stress (ER) in melanoma cells', Archives of Dermatological Research (2007) [E3]
Co-authors Xu Zhang
2007 Jiang CC, Chen IH, Kiejda KA, Gillespie SK, Hersey P, Zhang XD, 'The unfolded protein response induced by tunicamycin or thapsigargin sensitizes human melanoma cells to trail-induced apoptosis by selective up-regulaton of trail-R2 on te cell surface', 19th Lorne Cancer Conference (2007) [E3]
Co-authors Xu Zhang, Kelly Kiejda
2007 Zhang XD, Jiang CC, Wang YF, Kiejda KA, Gillespie SK, Hersey P, 'Regulation of the BCL-2 family members BIM, PUMA and MCL-1 by MEK/ERK signaling plays a critical role in survival of melanoma cells', 19th Lorne Cancer Conference (2007) [E3]
Co-authors Kelly Kiejda, Xu Zhang
2007 Zhang XD, Jiang CC, Wang YF, Kiejda KA, Hersey P, 'The MEK-ERK pathway potentiates adaptation of melanoma to endoplasmic reticulum stress', 4th Garvan Signalling Symposium. Conference Proceedings (2007) [E3]
Co-authors Kelly Kiejda, Xu Zhang
2007 Jiang CC, Wang YF, Kiejda KA, Gillespie SK, Zhang XD, Hersey P, 'Regulation of the Bcl-2 family members Bim, PUMA and Mcl-1 by MEK/ERK signaling plays a critical role in survival of melanoma cells', AACR Meeting Abstracts Online (Abstracts of the 98th AACR Annual Meeting) (2007) [E3]
Co-authors Kelly Kiejda, Xu Zhang
2007 Jiang C, Wang YF, Kiejda KA, Zhang XD, Hersey P, 'MEK/ERK-mediated regulation of the Bcl-2 family members Mcl-1, PUMA, and Bim contributes to survival of human melanoma cells', 4th Garvan Signaling Symposium (2007)
2007 Jiang C, Wang YF, Kiejda KA, Zhang XD, Hersey P, 'Apoptosis induction by inhibition of MEK is mediated by the Bcl-2 family members Bim, PUMA and Mcl-1.', 98th Annual Meeting of American Association for Cancer Research (2007)
2007 Zhang XD, Jiang C, Chen LH, Kiejda KA, Hersey P, 'The unfolded protein response selectively up-regulates TRAIL-R2 and enhances TRAIL-induced apoptosis in human melanoma cells.', 98th Annual Meeting of American Association for Cancer Research (2007)
2006 Jiang CC, Wang YF, Kiejda KA, Zhang XD, Hersey P, 'CD133, A potential marker for cancer stem cells in melanoma', HMRI Conference on Translational Cancer Research. Molecular Mechanisms and Implications for Treatment (2006) [E3]
Co-authors Kelly Kiejda, Xu Zhang
2006 Wang YF, Jiang CC, Kiejda KA, Zhang XD, Hersey P, 'Suppression of the BH3-only proteins BUM and PUMA by MEK/ERK signaling plays a crucial role in maintaining survival of melanoma cells', HMRI Conference on Translational Cancer Research. Molecular Mechanisms and Implications for Treatment (2006) [E3]
Co-authors Kelly Kiejda, Xu Zhang
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Grants and Funding

Summary

Number of grants 27
Total funding $3,300,305

Click on a grant title below to expand the full details for that specific grant.


20157 grants / $1,185,095

Overcoming Resistance of Metastatic Melanoma to treatment: MicroRNA-dependent expression of INPP4B as a biomarker and therapeutic target in melanoma$598,176

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Doctor Chen Chen Jiang
Scheme Career Development Fellowship
Role Lead
Funding Start 2015
Funding Finish 2017
GNo G1400739
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Advanced Technical Support for Oncology Single Cell Analysis Technologies$300,000

Funding body: Cancer Institute NSW

Funding body Cancer Institute NSW
Project Team Professor Rodney Scott, Professor Xu Dong Zhang, Professor Hubert Hondermarck, Conjoint Professor Stephen Ackland, Doctor Craig Gedye, Doctor Pradeep Tanwar, Doctor Chen Chen Jiang, Doctor Matt Dun, Professor Paul de Souza, Associate Professor Kevin Spring, Dr Tao Liu
Scheme Research Infrastructure Grants
Role Investigator
Funding Start 2015
Funding Finish 2018
GNo G1500824
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Necropotosis induced by Hexokinase-II inhibitor in breast cancer$150,555

Funding body: The National Natural Science Fund

Funding body The National Natural Science Fund
Project Team

Hao Liu

Scheme The National Natural Science Fund
Role Investigator
Funding Start 2015
Funding Finish 2017
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Development of tumor cells energy metabolism based necropotosis inhibitor$66,666

Funding body: Foreign cooperation project grant in science and technology

Funding body Foreign cooperation project grant in science and technology
Scheme Foreign cooperation project grant in science and technology
Role Lead
Funding Start 2015
Funding Finish 2017
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

High throughput automated all-in-one laser scanning FLUOVIEW FV10i microscope$54,698

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Xu Dong Zhang, Professor Robert Callister, Laureate Professor John Aitken, Doctor Pradeep Tanwar, Doctor Chen Chen Jiang, Doctor Lei Jin
Scheme Equipment Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1501576
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

The Long non-coding RNA lnc-DAGLA-1 as a biomarker and therapeutic target in melanoma. $10,000

Funding body: Faculty of Health, University of Newcastle

Funding body Faculty of Health, University of Newcastle
Project Team

Lei Jin

Scheme Strategic Research Pilot Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo
Type Of Funding Internal
Category INTE
UON N

Co-targeting CD47 and PD-L1 to enhance the efficacy of immunotherapy in melanoma.$5,000

Funding body: Faculty of Health, University of Newcastle

Funding body Faculty of Health, University of Newcastle
Scheme Strategic Research Pilot Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo
Type Of Funding Internal
Category INTE
UON N

20141 grants / $20,000

Overcoming resistance of KRAS mutant colon cancer to treatment by targeting heat shock protein 90$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Chen Chen Jiang, Professor Xu Dong Zhang
Scheme Project Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1401417
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20134 grants / $898,651

Functional consequences of epigenetic repression of PIB5PA in melanoma$359,250

Funding body: Cancer Council NSW

Funding body Cancer Council NSW
Project Team Professor Xu Dong Zhang, Dr Helen Rizos, Doctor Rick Thorne, Doctor Chen Chen Jiang
Scheme Research Grant
Role Investigator
Funding Start 2013
Funding Finish 2016
GNo G1200386
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Targeting PP2A to improve the therapeutic efficacy of mutant BRAF inhibitors in melanoma$359,250

Funding body: Cancer Council NSW

Funding body Cancer Council NSW
Project Team Professor Xu Dong Zhang, Doctor Nikki Verrills, Doctor Chen Chen Jiang
Scheme Research Grant
Role Investigator
Funding Start 2013
Funding Finish 2016
GNo G1200388
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Targeting microRNA-768-3p to overcome the resistance of human nasopharyngeal carcinoma cells to treatment. $155,555

Funding body: The National Natural Science Fund

Funding body The National Natural Science Fund
Scheme The National Natural Science Fund
Role Lead
Funding Start 2013
Funding Finish 2017
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

20125 grants / $430,974

Targeting Histone Deacetylases to Overcome Resistance of BRAFV600E Melanoma Cells to Apoptosis$346,974

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Xu Dong Zhang, Conjoint Professor Peter Hersey, Dr Tao Liu, Doctor Chen Chen Jiang, Doctor Rick Thorne
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2014
GNo G1100133
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The Role of Phosphatidylinositol 4, 5-Bisphosphate 5-Phosphatase A (PIB5PA) in Regulation of PI3K/Akt Signalling in Melanoma$24,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Xu Dong Zhang, Doctor Chen Chen Jiang
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1101121
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

A p53-Mediated Pro-Survival Signaling Pathway in Human Melanoma Progression and Resistance to Treatment$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Xu Dong Zhang, Doctor Rick Thorne, Doctor Chen Chen Jiang
Scheme Near Miss Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200672
Type Of Funding Internal
Category INTE
UON Y

Targeting ER stress to sensitize head and neck and maxillofacial tumor cells to chemotherapeutic reagents$20,000

Funding body: The Natural Science Foundation of Anhui Province

Funding body The Natural Science Foundation of Anhui Province
Project Team

Jing Cheng Xu, Zhi Wen Jiang, Hao Liu

Scheme The Natural Science Foundation of Anhui Province
Role Investigator
Funding Start 2012
Funding Finish 2013
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Biological polysaccharide anti-tumor drug research collaborative innovation centre$20,000

Funding body: Bengbu Medical College

Funding body Bengbu Medical College
Project Team

Zhi Wen Jiang, Hao Liu

Scheme Bengbu Medical College
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo
Type Of Funding Not Known
Category UNKN
UON N

20114 grants / $487,253

Targeting survival pathways to overcome the resistance of human melanoma to treatment$320,032

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Chen Chen Jiang
Scheme Training (Postdoctoral) Fellowships - Peter Doherty Biomedical Fellowship (Australia)
Role Lead
Funding Start 2011
Funding Finish 2014
GNo G1000530
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The role of Endoplasmic Reticulum stress in regulating sensitivity of human nasopharyngeal carcinoma cells to chemotherapy$75,555

Funding body: The National Natural Science Fund

Funding body The National Natural Science Fund
Scheme The National Natural Science Fund
Role Lead
Funding Start 2011
Funding Finish 2013
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

The role of RIPK1 in regulating sensitivity of tumor cells to SMAC mimetic-induced cell death$66,666

Funding body: The National Natural Science Fund

Funding body The National Natural Science Fund
Project Team

Hao Liu

Scheme The National Natural Science Fund
Role Investigator
Funding Start 2011
Funding Finish 2013
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

Regulation of BimS splicing in response of human melanoma cells to inhibition of BRAFVV600E$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Chen Chen Jiang, Professor Xu Dong Zhang
Scheme Project Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1000988
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20104 grants / $145,000

MicroRNAs in adaptation of human melanoma cells to endoplasmic reticulum stress$90,000

Funding body: Cure Cancer Australia Foundation

Funding body Cure Cancer Australia Foundation
Project Team Doctor Chen Chen Jiang
Scheme Research Grant
Role Lead
Funding Start 2010
Funding Finish 2011
GNo G0190493
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Regulation of BimS splicing in response of human melanoma cells to inhibition of mutant BRAF.$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Scheme Project Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo
Type Of Funding Other Public Sector - Local
Category 2OPL
UON N

The role of micro-RNA-149 in Regulation of Mcl-1 in Human Melanoma under stress$20,000

Funding body: Hunter Children`s Research Foundation

Funding body Hunter Children`s Research Foundation
Project Team Doctor Chen Chen Jiang, Professor Xu Dong Zhang
Scheme Research Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G0900189
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

The role of microRNA-149* in regulation of Mcl-1 in human melanoma under ER stress. $10,000

Funding body: Calvary Mater Newcastle Hospital

Funding body Calvary Mater Newcastle Hospital
Scheme Margaret Mitchell Research Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo
Type Of Funding Other Public Sector - Local
Category 2OPL
UON N

20092 grants / $133,332

The role of heparan sulfate proteoglycan in regulating sensitivity of breast cancer cells to ER-stress induced cell death$66,666

Funding body: The Natural Science Foundation of Anhui Province

Funding body The Natural Science Foundation of Anhui Province
Project Team

Zhi Wen Jiang, Hao Liu

Scheme The Natural Science Foundation of Anhui Province
Role Investigator
Funding Start 2009
Funding Finish 2011
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N

R & D of heparin structure modification and anti-tumor effects$66,666

Funding body: The Natural Science Foundation of Anhui Province

Funding body The Natural Science Foundation of Anhui Province
Project Team

Zhi Wen Jiang, Hao Liu

Scheme The Natural Science Foundation of Anhui Province
Role Investigator
Funding Start 2009
Funding Finish 2011
GNo
Type Of Funding International - Competitive
Category 3IFA
UON N
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Research Supervision

Number of supervisions

Completed3
Current3

Total current UON EFTSL

PhD1.05

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2014 PhD Mir-645 is an oncomir in colorectal carcinoma
PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 PhD Targeting Heat Shock Protein Hsp90 in Colon Cancer
PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2013 PhD A Framework for Aspect-Oriented Requirement Modelling and Architecture Development in Software Product Line
PhD (Software Engineering), Faculty of Engineering and Built Environment, The University of Newcastle
Co-Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2014 PhD Targeting Adaptive Mechanisms to Endoplasmic Reticulum Stress in Melanoma
Surgery, Faculty of Health, University of Newcastle
Co-Supervisor
2014 PhD Inositol Polyphosphate 4-Phosphatese 11 (INPP4B) Promotes PI3K Signalling and Functions as an Oncogenic Regulator in Human Colon Cancer and Melanoma
Surgery, Faculty of Health, University of Newcastle
Co-Supervisor
2014 PhD Regulation of Apoptosis Induced by Targeting the RAF/MEK/ERK Pathway in Human Melanoma
PhD (Surgical Science), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
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Research Collaborations

The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.

Country Count of Publications
Australia 65
China 37
United Kingdom 2
France 1
United States 1
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Dr Chen Chen Jiang

Position

Cancer Institute NSW Career Development Fellow
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Email chenchen.jiang@newcastle.edu.au
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