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Associate Professor Paul Tooney

Associate Professor

School of Biomedical Sciences and Pharmacy (Pharmacy and Experimental Pharmacology)

Brainstorming the brain

Associate Professor Paul Tooney regards his research into schizophrenia as one piece of a complex puzzle that spans many disciplines.

Paul Tooney speaking to a colleague 

Associate Professor Paul Tooney was undertaking postdoctoral cancer research in the United States when an opportunity to move to Newcastle to apply his cutting-edge skills in cellular and molecular biology to the study of schizophrenia changed the course of his career. Faced with the task of quickly familiarising himself with his new field, Tooney embarked on a self-styled orientation program that both schooled him in the fundamental aspects of the disorder and taught him much about the power of collaboration, a principle that has continued to guide his work.

"Many of my lab skills were transferrable but I really wanted to learn more about schizophrenia," Tooney recalls. "So, I attended clinical research seminars and grand rounds (case-study discussions) with doctors at the local mental health hospital and sat in on a brain anatomy course to enhance my knowledge of neuroscience.

"That allowed me to establish a rapport with many of the wonderful researchers and clinicians here from different disciplines working in the field of psychiatric illness. It became clear to me then that I could either sit in my silo and look exclusively at neurons in the brain or I could get out and see how my research could complement the work of others."

In 1998, Tooney moved to the University of Newcastle as a senior research officer supported by the Schizophrenia Research Institute (SRI), a University partner organisation. He received an academic appointment in 2004 and has since established an extensive collaborative network. Driven by the goal of developing a biological means of diagnosing schizophrenia and identifying new targets for drug discovery, his work draws on the expertise of colleagues in neuroscience, psychiatry, behavioural science, cell biology, genetics, bioinformatics and brain imaging.

Tooney was influential in establishing the Hunter DNA Bank for Schizophrenia and Allied Disorders, and later the nationwide Australian Schizophrenia Research Bank (ASRB) – the genetics arm of which is headquartered in Newcastle. The ASRB is a unique national database of comprehensive medical information collected uniformly from thousands of people, both with schizophrenia and without. Since the bank was launched in 2007, the information collected has been used in more than 65 research projects and over 35 scientific publications.

A strong focus of Tooney's interdisciplinary research is looking for possible subtypes of schizophrenia, using state-of-the-art technologies to study RNA and DNA molecules extracted from brain and peripheral tissue.

"When people are diagnosed with schizophrenia, we put them all into one basket but we know there are differences in the ways that people are affected, so it is likely that we actually have multiple disorders coming under this one diagnosis," Tooney explains. "I am striving to find a genetic basis for these subtypes, cross-referencing my research with patterns that psychologists and psychiatrists see in behaviour and cognition, so that we might be able to classify the disease better.

"Ultimately, if we can develop blood-based diagnostic tests that identify not only who has, or is likely to develop, schizophrenia but also what type of schizophrenia they have, then we might be able to improve our treatments, and in the process understand more about the disorder in general."

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Paul Tooney speaking to a colleague

Brainstorming the brain

Associate Professor Paul Tooney regards his research into schizophrenia as one piece of a complex puzzle that spans many disciplines.

Read more

Career Summary

Biography

Paul has a keen interest in understanding the cellular and molecular mechanisms of diseases, so that better diagnoses and treatment strategies can be developed. He completed a BSc (Hon) Class 1 (1985-1989) and a PhD (awarded 1995) from the University of Newcastle, Australia. He then travelled to the USA (1995-1998) and completed post-doctoral research at the University of Wisconsin. His research background during his PhD and postdoctoral work was in cancer biology where he gained experience in cellular and molecular biology techniques. In March 1998, Paul returned to Australia and took the opportunity to focus on the neurobiology of schizophrenia and joined the Schizophrenia Research Institute (formerly the Neuroscience Institute of Schizophrenia and Allied Disorders) as a Research Officer (1998-2000) and Senior Research Officer (2000-2004). In 2004, Paul was appointed to an academic position in the School of Biomedical Sciences and Pharmacy, Faculty of Health University of Newcastle.

Paul’s research from 1998 to date has focused on the neurobiology and genetics underpinning schizophrenia. He has conducted and collaborated on world-class studies detailing the changes to gene expression in the brain and also the blood from patients with schizophrenia. These studies showed that people with schizophrenia have distinct changes in their expression of genes in their brains and the blood. Interestingly many of these studies suggest changes in genes that have roles in the immune system and inflammatory processes/ As part of these efforts Paul played a major role in the establishment of the Australian Schizophrenia Research Bank (ASRB), which recruits participants with schizophrenia and controls and collects clinical and cognitive data as well as blood samples for genetic analysis and MRI structural brain scans from the participants. This huge data resource is currently being investigated by many groups to improve our understanding of what causes schizophrenia so that we can better identify who is likely to develop schizophrenia so that we can identify new treatments or preventative strategies for this devastating disorder.

More recently Paul established two new projects. One project is investigating why people with schizophrenia have more inhibitory interneurons in the white matter underneath the cortex of brain regions known to be affected in schizophrenia. The other project is investigating the levels of auto-antibodies directed against neuronal antigens in people with schizophrenia.

Research Expertise
Paul's research expertise is in cell and molecular biology. His research efforts during his PhD and postdoctoral training were directed at cancer biology using standard cell culture assays, immunofluorescnece labling of cultured cells, flow cytometry and molecular biology techniques. Since 1998, Paul has focused on the neurobiology of schizophrenia and has developed additional experience with molecular techniques to study gene expression changes in brain and blood samples. He also has experience in using immunolablelling techniques (immunofluorescence and immunohistochemistry) coupled with microscopy and cell counting to study changes in neurons in the brains of people with schizophrenia and in rodent models.

Teaching Expertise
Paul has expertise in teaching basic cell and molecular biology, pharmacology and coordinates a course on professional skills for biomedical science students. He has taught into the Biomedical Science, Medicine, Pharmacy, Nursing and Physiotherapy Programs.

Administrative Expertise
Paul was the B. Biomedical Science Program Convenor from 2008 to 2012

Collaborations
My current research interests are in the understanding of the neurobiology and genetics of schizophrenia so that better diagnoses and treatment strategies can be developed. Currently my research collaborations are around the following projects: 1. Investigation of the genetic basis of schizophrenia with the Neurobehavioural Genetics Unit 2. Investigation of the neurobiology and changes to interneurons in the white matter of the brain in schizophrenia. 3. Investigation of the level of autoantibodies directed against neuronal antigens in people with schizophrenia. 4. The Australian Schizophrenia Research Bank: http://www.schizophreniaresearch.org.au/bank/


Qualifications

  • PhD, University of Newcastle
  • Bachelor of Science, University of Newcastle
  • Bachelor of Science (Honours), University of Newcastle
  • Graduate Certificate Practice of Tertiary Teaching, University of Newcastle

Keywords

  • Biomedical Science
  • Cell Biology
  • Gene expression
  • Interneurons
  • Neurobiology
  • Pharmacology
  • Research Skills
  • Schizophrenia

Fields of Research

CodeDescriptionPercentage
060410Neurogenetics10
110319Psychiatry (incl. Psychotherapy)45
110999Neurosciences not elsewhere classified45

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/07/2014 - Associate ProfessorUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

DatesTitleOrganisation / Department
1/07/2012 - Associate ProfessorUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/2008 - 1/06/2012Senior LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/07/2004 - 1/12/2007LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/07/2000 - 1/07/2004Senior Research OfficerNeuroscience Institute of Schizophrenia and Allied Disorders (NISAD)
Australia
1/03/1998 - 1/06/2000Research OfficerNeuroscience Institute of Schizophrenia and Allied Disorders (NISAD)
Australia
1/03/1995 - 1/02/1998Postdoctoral Research Associate
Cancer Biology
University of Wisconsin-Madison
Faculty of Medicine
United States
1/01/1990 - 1/12/1990Research AssistantUniversity of Newcastle
Faculty of Medicine
Australia

Membership

DatesTitleOrganisation / Department
Affiliated Scientist - Schizophrenia Research InstituteSchizophrenia Research Institute
General Member - Australian Neuroscience SocietyAustralian Neuroscience Society (ANS)
Australia

Awards

Research Award

YearAward
1991Australian Postgraduate Research Award
University of Newcastle

Invitations

Participant

YearTitle / Rationale
2001Tachykinin NK1 receptor immunoreactivity is increased in the prefrontal cortex in schizophrenia
Organisation: International Congress On Schizophrenia Research Description: Invited to give oral presentation at International Congress On Schizophrenia Research in Canada 2001
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (45 outputs)

YearCitationAltmetricsLink
2014Oldmeadow C, Mossman D, Evans TJ, Holliday EG, Tooney PA, Cairns MJ, et al., 'Combined analysis of exon splicing and genome wide polymorphism data predict schizophrenia risk loci.', J Psychiatr Res, 52 44-49 (2014) [C1]
DOI10.1016/j.jpsychires.2014.01.011Author URL
CitationsScopus - 1Web of Science - 1
Co-authorsJohn Attia, Murray Cairns, Rodney Scott, Liz Holliday, Christopher Oldmeadow
2014McCarthy-Jones S, Green MJ, Scott RJ, Tooney PA, Cairns MJ, Wu JQ, et al., 'Preliminary evidence of an interaction between the FOXP2 gene and childhood emotional abuse predicting likelihood of auditory verbal hallucinations in schizophrenia', JOURNAL OF PSYCHIATRIC RESEARCH, 50 66-72 (2014) [C1]
DOI10.1016/j.jpsychires.2013.11.012Author URL
CitationsScopus - 2Web of Science - 2
Co-authorsChristopher Oldmeadow, Murray Cairns, Rodney Scott
2014Green MJ, Chia T-Y, Cairns MJ, Wu J, Tooney PA, Scott RJ, Carr VJ, 'Catechol-O-methyltransferase (COMT) genotype moderates the effects of childhood trauma on cognition and symptoms in schizophrenia', Journal of Psychiatric Research, 49 43-50 (2014) [C1]

The interaction of genetic and environmental factors may affect the course and development of psychotic disorders. We examined whether the effects of childhood trauma on cognition and symptoms in schizophrenia were moderated by the Catechol-O-methyltransferase (COMT) Val158Met polymorphism, a common genetic variant known to affect cognition and prefrontal dopamine levels. Participants were 429 schizophrenia/schizoaffective cases from the Australian Schizophrenia Research Bank (ASRB). Cognitive performance was assessed using the Repeatable Battery for Assessment of Neuropsychological Status (RBANS), Controlled Oral Word Association Test (COWAT), Letter Number Sequencing (LNS) test, and the Wechsler Test of Adult Reading (WTAR). Hierarchical regression was used to test the main effects and additive interaction effects of genotype and childhood trauma in the domains of physical abuse, emotional abuse, and emotional neglect, on cognition and symptom profiles of clinical cases. Consistent with previous findings, COMT Val homozygotes performed worse on cognitive measures in the absence of childhood adversity. In addition, a significant interaction between COMT genotype and physical abuse was associated with better executive function in Val homozygotes, relative to those of the same genotype with no history of abuse. Finally, the severity of positive symptoms was greater in Met carriers who had experienced physical abuse, and the severity of negative symptoms in Met carriers was greater in the presence of emotional neglect. These results suggest that the possible epigenetic modulation of the expression of the COMT Val158Met polymorphism and consequent effects on cognition and symptoms in schizophrenia, with worse outcomes associated with adverse childhood experiences in Met carriers. © 2013 Elsevier Ltd.

DOI10.1016/j.jpsychires.2013.10.018
CitationsScopus - 3Web of Science - 1
Co-authorsMurray Cairns, Rodney Scott
2014Green MJ, Chia T-Y, Carr VJ, Cairns MJ, Tooney PA, Scott RJ, Wu J, 'Catechol-O-methyltransferase (COMT) genotype moderates the effects of childhood trauma on cognition and symptoms in schizophrenia', Journal of Psychiatric Research, 49 43-50 (2014)
DOI10.1016/j.jpsychires.2013.10.018
Co-authorsMurray Cairns, Rodney Scott
2014Kumarasinghe N, Rasser PE, Mendis J, Bergmann J, Knechtel L, Oxley S, et al., 'Age effects on cerebral grey matter and their associations with psychopathology, cognition and treatment response in previously untreated schizophrenia patients', Neurology Psychiatry and Brain Research, 20 29-36 (2014) [C1]
DOI10.1016/j.npbr.2014.01.001
Co-authorsUlrich Schall
2014Gardiner E, Carroll A, Tooney PA, Cairns MJ, 'Antipsychotic drug-associated gene-miRNA interaction in T-lymphocytes', International Journal of Neuropsychopharmacology, 17 929-943 (2014)
DOI10.1017/S1461145713001752
Co-authorsMurray Cairns
2014Gardiner E, Carroll A, Tooney PA, Cairns MJ, 'Antipsychotic drug-associated gene-miRNA interaction in T-lymphocytes', International Journal of Neuropsychopharmacology, 17 929-943 (2014) [C1]

Antipsychotic drugs (APDs) can have a profound effect on the human body that extends well beyond our understanding of their neuropsychopharmacology. Some of these effects manifest themselves in peripheral blood lymphocytes, and in some cases, particularly in clozapine treatment, result in serious complications. To better understand the molecular biology of APD action in lymphocytes, we investigated the influence of chlorpromazine, haloperidol and clozapine in vitro, by microarray-based gene and microRNA (miRNA) expression analysis. JM-Jurkat T-lymphocytes were cultured in the presence of the APDs or vehicle alone over 2 wk to model the early effects of APDs on expression. Interestingly both haloperidol and clozapine appear to regulate the expression of a large number of genes. Functional analysis of APD-associated differential expression revealed changes in genes related to oxidative stress, metabolic disease and surprisingly also implicated pathways and biological processes associated with neurological disease consistent with current understanding of the activity of APDs. We also identified miRNA-mRNA interaction associated with metabolic pathways and cell death/survival, all which could have relevance to known side effects of APDs. These results indicate that APDs have a significant effect on expression in peripheral tissue that relate to both known mechanisms as well as poorly characterized side effects. © CINP 2014.

DOI10.1017/S1461145713001752
CitationsScopus - 2Web of Science - 2
Co-authorsMurray Cairns
2013Carroll AP, Tooney PA, Cairns MJ, 'Design and interpretation of microRNA-reporter gene activity', Analytical Biochemistry, 437 164-171 (2013) [C1]

MicroRNAs (miRNAs) are small noncoding RNA molecules that act as sequence specificity guides to direct post-transcriptional gene silencing. In doing so, miRNAs regulate many critical developmental processes, including cellular proliferation, differentiation, migration, and apoptosis, as well as more specialized biological functions such as dendritic spine development and synaptogenesis. Interactions between miRNAs and their miRNA recognition elements occur via partial complementarity, rendering tremendous redundancy in targeting such that miRNAs are predicted to regulate 60% of the genome, with each miRNA estimated to regulate more than 200 genes. Because these predictions are prone to false positives and false negatives, there is an ever present need to provide material support to these assertions to firmly establish the biological function of specific miRNAs in both normal and pathophysiological contexts. Using schizophrenia-associated miR-181b as an example, we present detailed guidelines and novel insights for the rapid establishment of a streamlined miRNA-reporter gene assay and explore various design concepts for miRNA-reporter gene applications, including bidirectional miRNA modulation. In exemplifying this approach, we report seven novel miR-181b target sites for five schizophrenia candidate genes (DISC1, BDNF, ENKUR, GRIA1, and GRIK1) and dissect a number of vital concepts regarding future developments for miRNA-reporter gene assays and the interpretation of their results. © 2013 Elsevier Inc. All rights reserved.

DOI10.1016/j.ab.2013.02.022
CitationsScopus - 4Web of Science - 3
Co-authorsMurray Cairns
2013Gardiner EJ, Cairns MJ, Liu B, Beveridge NJ, Carr V, Kelly B, et al., 'Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells', JOURNAL OF PSYCHIATRIC RESEARCH, 47 425-437 (2013) [C1]
DOI10.1016/j.jpsychires.2012.11.007Author URL
CitationsScopus - 13Web of Science - 14
Co-authorsBrian Kelly, Murray Cairns, Rodney Scott
2013Santarelli DM, Liu B, Duncan CE, Beveridge NJ, Tooney PA, Schofield PR, Cairns MJ, 'Gene-microRNA interactions associated with antipsychotic mechanisms and the metabolic side effects of olanzapine', PSYCHOPHARMACOLOGY, 227 67-78 (2013) [C1]
DOI10.1007/s00213-012-2939-yAuthor URL
CitationsScopus - 4Web of Science - 6
Co-authorsMurray Cairns
2013Green MJ, Cairns MJ, Wu J, Dragovic M, Jablensky A, Tooney PA, et al., 'Genome-wide supported variant MIR137 and severe negative symptoms predict membership of an impaired cognitive subtype of schizophrenia', MOLECULAR PSYCHIATRY, 18 774-780 (2013) [C1]
DOI10.1038/mp.2012.84Author URL
CitationsScopus - 9Web of Science - 25
Co-authorsMurray Cairns, Rodney Scott
2013Green MJ, Cairns MJ, Wu J, Dragovic M, Jablensky A, Tooney PA, et al., 'Genome-wide supported variant MIR137 and severe negative symptoms predict membership of an impaired cognitive subtype of schizophrenia', Molecular Psychiatry, (2013) [C1]
DOI10.1038/mp.2013.48
CitationsScopus - 20
2013Kumarasinghe N, Beveridge NJ, Gardiner E, Scott RJ, Yasawardene S, Perera A, et al., 'Gene expression profiling in treatment-naive schizophrenia patients identifies abnormalities in biological pathways involving AKT1 that are corrected by antipsychotic medication', INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 16 1483-1503 (2013) [C1]
DOI10.1017/S1461145713000035Author URL
CitationsScopus - 5Web of Science - 5
Co-authorsUlrich Schall, Rodney Scott
2013Carroll AP, Tooney PA, Cairns MJ, 'Context-specific microRNA function in developmental complexity', Journal of Molecular Cell Biology, 5 73-84 (2013) [C1]

Since their discovery, microRNAs (miRNA) have been implicated in a vast array of biological processes in animals, from fundamental developmental functions including cellular proliferation and differentiation, to more complex and specialized roles such as long-term potentiation and synapse-specific modifications in neurons. This review recounts the history behind this paradigm shift, which has seen small non-coding RNA molecules coming to the forefront of molecular biology, and introduces their role in establishing developmental complexity in animals. The fundamental mechanisms of miRNA biogenesis and function are then considered, leading into a discussion of recent discoveries transforming our understanding of how these molecules regulate gene network behaviour throughout developmental and pathophysiological processes. The emerging complexity of this mechanism is also examined with respect to the influence of cellular context on miRNA function. This discussion highlights the absolute imperative for experimental designs to appreciate the significance of context-specific factors when determining what genes are regulated by a particular miRNA. Moreover, by establishing the timing, location, and mechanism of these regulatory events, we may ultimately understand the true biological function of a specific miRNA in a given cellular environment. © The Author (2013).

DOI10.1093/jmcb/mjt004
CitationsScopus - 14Web of Science - 14
Co-authorsMurray Cairns
2012Kumarasinghe KMN, Tooney PA, Schall UA, 'Finding the needle in the haystack: A review of microarray gene expression research into schizophrenia', Australian and New Zealand Journal of Psychiatry, 46 598-610 (2012) [C1]
CitationsScopus - 11Web of Science - 10
Co-authorsUlrich Schall
2012Gardiner EJ, Beveridge NJ, Wu JQ, Carr VJ, Scott R, Tooney PA, Cairns MJ, 'Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells', Molecular Psychiatry, 17 827-840 (2012) [C1]
CitationsScopus - 57Web of Science - 50
Co-authorsRodney Scott, Murray Cairns
2012Carroll AP, Tran N, Tooney PA, Cairns MJ, 'Alternative mRNA fates identified in microRNA-associated transcriptome analysis', BMC Genomics, 13 1-19 (2012) [C1]
CitationsScopus - 13Web of Science - 11
Co-authorsMurray Cairns
2012Wu JQ, Wang X, Beveridge NJ, Tooney PA, Scott R, Carr VJ, Cairns MJ, 'Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia', PLoS One, 7 e36351 (2012) [C1]
CitationsScopus - 21Web of Science - 20
Co-authorsMurray Cairns, Rodney Scott
2011Santarelli DMF, Beveridge NJ, Tooney PA, Cairns MJ, 'Upregulation of dicer and MicroRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia', Biological Psychiatry, 69 180-187 (2011) [C1]
DOI10.1016/j.biopsych.2010.09.030
CitationsScopus - 85Web of Science - 80
Co-authorsMurray Cairns
2011Case VS, Soyland A, Tooney PA, Thompson PM, Rasser PE, Schall UA, et al., 'Gray matter deficits, mismatch negativity, and outcomes in schizophrenia', Schizophrenia Bulletin, 37 131-140 (2011) [C1]
CitationsScopus - 53Web of Science - 49
Co-authorsUlrich Schall, Juanita Todd, Pat Michie
2010Loughland CM, Draganic D, McCabe KL, Richards JM, Nasir MA, Allen J, et al., 'Australian Schizophrenia Research Bank: A database of comprehensive clinical, endophenotypic and genetic data for aetiological studies of schizophrenia', Australian and New Zealand Journal of Psychiatry, 44 1029-1035 (2010) [C1]
DOI10.3109/00048674.2010.501758
CitationsWeb of Science - 19
Co-authorsPat Michie, Ulrich Schall, Rodney Scott, Carmel Loughland, Frans Henskens
2010Beveridge NJ, Gardiner EJ, Carroll AP, Tooney PA, Cairns MJ, 'Schizophrenia is associated with an increase in cortical microRNA biogenesis', Molecular Psychiatry, 15 1176-1189 (2010) [C1]
DOI10.1038/mp.2009.84
CitationsScopus - 146Web of Science - 116
Co-authorsMurray Cairns
2009Anderson WB, Graham BA, Beveridge NJ, Tooney PA, Brichta AM, Callister RJ, 'Different forms of glycine- and GABA(A)-receptor mediated inhibitory synaptic transmission in mouse superficial and deep dorsal horn neurons', Molecular Pain, 5 1-16 (2009) [C1]
DOI10.1186/1744-8069-5-65
CitationsScopus - 8Web of Science - 7
Co-authorsBrett Graham, Robert Callister, Alan Brichta
2009Weidenhofer JC, Scott R, Tooney PA, 'Investigation of the expression of genes affecting cytomatrix active zone function in the amygdala in schizophrenia: Effects of antipsychotic drugs', Journal of Psychiatric Research, 43 282-290 (2009) [C1]
DOI10.1016/j.jpsychires.2008.04.001
CitationsScopus - 6Web of Science - 6
Co-authorsJudith Weidenhofer, Rodney Scott
2009Beveridge NJ, Tooney PA, Carroll AP, Tran N, Cairns MJ, 'Down-regulation of miR-17 family expression in response to retinoic acid induced neuronal differentiation', Cellular Signalling, 21 1837-1845 (2009) [C1]
DOI10.1016/j.cellsig.2009.07.019
CitationsScopus - 54Web of Science - 52
Co-authorsMurray Cairns
2008Bowden NA, Scott R, Tooney PA, 'Altered gene expression in the superior temporal gyrus in schizophrenia', BMC Genomics, 9 1-12 (2008) [C1]
DOI10.1186/1471-2164-9-199
CitationsScopus - 32Web of Science - 32
Co-authorsRodney Scott, Nikola Bowden
2008Beveridge NJ, Tooney PA, Carroll AP, Gardiner EJ, Bowden NA, Scott R, et al., 'Dysregulation of miRNA 181b in the temporal cortex in schizophrenia', Human Molecular Genetics, 17 1156-1168 (2008) [C1]
DOI10.1093/hmg/ddn005
CitationsScopus - 166Web of Science - 161
Co-authorsMurray Cairns, Rodney Scott, Nikola Bowden
2007Bowden NA, Scott R, Tooney PA, 'Altered expression of regulator of G-protein signalling 4 (RGS4) mRNA in the superior temporal gyrus in schizophrenia', Schizophrenia Research, 89 165-168 (2007) [C1]
DOI10.1016/j.schres.2006.09.003
CitationsScopus - 33Web of Science - 36
Co-authorsRodney Scott, Nikola Bowden
2006Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Altered gene expression in the amygdala in schizophrenia: Up-regulation of genes located in the cytomatrix active zone', Molecular and Cellular Neuroscience, 31 243-250 (2006) [C1]
DOI10.1016/j.mcn.2005.09.013
CitationsScopus - 34Web of Science - 34
Co-authorsRodney Scott, Judith Weidenhofer, Nikola Bowden
2006Weidenhofer JC, Yip JR, Zavitsanou K, Huang XF, Chahl LA, Tooney PA, 'Immunohistochemical localisation of the NK1 receptor in the human amygdala: Preliminary investigation in schizophrenia', Progress in Neuro-Psychopharmacology and Biological Psychiatry, 30 1313-1321 (2006) [C1]
DOI10.1016/j.pnpbp.2006.05.008
CitationsScopus - 5Web of Science - 5
Co-authorsJudith Weidenhofer
2006Bowden NA, Weidenhofer JC, Scott R, Schall U, Todd J, Michie PT, Tooney PA, 'Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophrenia', Schizophrenia Research, 82 175-183 (2006) [C1]
DOI10.1016/j.schres.2005.11.012
CitationsScopus - 77Web of Science - 67
Co-authorsUlrich Schall, Nikola Bowden, Rodney Scott, Judith Weidenhofer, Juanita Todd, Pat Michie
2006Bowden NA, Tooney PA, Scott R, 'Gene expression profiling of xeroderma pigmentosum', Hereditary Cancer in Clinical Practice, 4 103-110 (2006) [C1]
DOI10.1186/1897-4287-4-2-103
CitationsScopus - 1
Co-authorsRodney Scott, Nikola Bowden
2006Weidenhofer J, Bowden NA, Scott RJ, Tooney PA, 'Dysfunction of genes regulating membrane exocytosis in schizophrenia', AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 40 A129-A129 (2006)
Author URL
Co-authorsNikola Bowden, Judith Weidenhofer, Rodney Scott
2005Tooney PA, Anderson WB, Lynch-Frame AM, Chahl LA, 'The effects of haloperidol treatment on the distribution of NK1 receptor immunoreactive neurons in guinea-pig brain (Short Communication)', Neuroscience Letters, 383 155-159 (2005) [C1]
DOI10.1016/j.neulet.2005.04.012
CitationsScopus - 4Web of Science - 4
2004Tooney PA, Chahl LA, 'Neurons expressing calcium-binding proteins in the prefrontal cortex in schizophrenia', Progress in Neuro-Psychopharmacology & Biological Psychiatry, 28 273-278 (2004) [C1]
DOI10.1016/j.pnpbp.2003.10.004
CitationsScopus - 25Web of Science - 24
2002Tooney PA, Yip J, Zavitsanou K, Huang X-F, Chahl LA, 'Distribution of Tachykinin Receptors in the Human Amygdala', Proceedings of the Australian Neuroscience Society, 13 182 (2002) [C3]
2001Tooney PA, Crawter VC, Chahl LA, 'Increased Tachykinin NK1 Receptor Immunoreactivity in the Prefrontal Cortex in Schizophrenia', Biological Psychiatry, 49 523-527 (2001) [C1]
CitationsScopus - 22Web of Science - 21
2001Tooney PA, Crawter VC, Chahl LA, 'Tachykinin NK1 receptor immunoreactivity is increased in the prefrontal cortex in schizophrenia', SCHIZOPHRENIA RESEARCH, 49 64-64 (2001)
Author URL
2000Tooney PA, Au GG, Chahl LA, 'Localisation of tachykinin NK1 and NK3 receptors in the human prefrontal and visual cortex', Neuroscience Letters, 283 185-188 (2000) [C1]
CitationsScopus - 34Web of Science - 36
Co-authorsGough Au
1998Tooney PA, Sakai T, Sakai K, Aeschlimann D, Mosher DF, 'Restricted localization of thrombospondin-2 protein during mouse embryogenesis: A comparison to thrombospondin-1', MATRIX BIOLOGY, 17 (2) 131-143 (1998) [C1]
CitationsScopus - 43Web of Science - 42
1993AGREZ MV, TOONEY P, BURNS GF, 'SRC-RELATED PROTEIN TYROSINE KINASES ARE INVOLVED IN INTEGRIN-MEDIATED COLLAGEN REORGANIZATION BY FIBROBLASTS', JOURNAL OF CELLULAR BIOCHEMISTRY, 113-113 (1993)
Author URL
1993BURNS GF, TOONEY PA, MELDRUM CJ, 'GLYCOPROTEIN-88 (CD36) BINDS TUBULIN AND ENDOGENOUS THROMBOSPONDIN', JOURNAL OF CELLULAR BIOCHEMISTRY, 158-158 (1993)
Author URL
1993BURNS GF, TOONEY P, DENICHILO M, MELDRUM C, DORAHY D, 'THE BIOLOGY OF CD36 - AN INTEGRIN-ASSOCIATED ADHESION MOLECULE', JOURNAL OF LEUKOCYTE BIOLOGY, 109-109 (1993)
Author URL
1993Tooney P, Agrez MV, Burns GF, 'A re-examination of the molecular mechanism of cell movement', Immunology and Cell Biology, 71 131-139 (1993) [C1]
CitationsScopus - 16Web of Science - 19
1990Smart YC, Tooney PA, Farrelly ML, Brien JH, Burton RC, 'Natural cytotoxic cells and tumour surveillance', European Journal of Cancer, 26 863-864 (1990) [C1]
CitationsScopus - 1Web of Science - 3
Show 42 more journal articles

Conference (44 outputs)

YearCitationAltmetricsLink
2015Ibrahim EC, Bergon A, Belzeaux R, Comte M, Pelletier F, Herve M, et al., 'Transcriptome Analyses of Human Brain and Blood Tissues Converge to Dysregulated Expression of CX3CR1', BIOLOGICAL PSYCHIATRY, Toronto, CANADA (2015)
Author URL
Co-authorsMurray Cairns, Rodney Scott, Brian Kelly
2012Gardiner EJ, Cairns MJ, Beveridge NJ, Liu B, Mossman D, Carr VJ, et al., 'Differential gene expression in peripheral blood mononuclear cells from a large cohort of participants with schizophrenia', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authorsMurray Cairns, Rodney Scott
2012Loughland CM, McCabe KL, Bridge JE, Henskens FA, Catts S, Jablensky A, et al., 'The Australian Schizophrenia Research Biobank (ASRB): An audit of the first five years of recruitment resource access', Schizophrenia Research, Florence, Italy (2012) [E3]
Co-authorsCarmel Loughland, Frans Henskens, Pat Michie, Rodney Scott, Ulrich Schall
2012Henskens FA, Paul DJ, Loughland CM, Bridge JE, McCabe KL, Catts S, et al., 'The Australian Schizophrenia Research Biobank (ASRB): IT development and management of a live e-research system', Schizophrenia Research, Florence, Italy (2012) [E3]
Co-authorsCarmel Loughland, Ulrich Schall, Pat Michie, Frans Henskens
2012Carroll AP, Tooney PA, Cairns MJ, 'Biological investigation of schizophrenia-associated miRNA dysregulation', Abstract Book. Biological Psychiatry Australia Scientific Meeting, Parkville, Vic (2012) [E3]
Co-authorsMurray Cairns
2011Wu J, Tooney PA, Wang X, Cairns MJ, 'Quantitative transcriptome sequencing reveals altered presynaptic vesicle trafficking and myelination in the temporal cortex in schizophrenia', Presentation Abstracts: XIXth World Congress of Psychiatric Genetics, Washington, DC (2011) [E3]
Co-authorsMurray Cairns
2011Loughland CM, McCabe KL, Catts S, Jablensky A, Henskens FA, Michie PT, et al., 'The Australian Schizophrenia Research Bank (ASRB): The first 550 schizophrenia sample profile', Schizophrenia Bulletin, Schizophrenia Bulletin (2011) [E3]
Co-authorsPat Michie, Rodney Scott, Ulrich Schall, Carmel Loughland, Frans Henskens
2011Mossman D, Tooney PA, Cairns MJ, Kelly BJ, Carr V, Scott R, 'Identification of alternatively spliced gene variants in schizophrenia', Schizophrenia Bulletin, Colorado Springs, CO (2011) [E3]
Co-authorsMurray Cairns, Brian Kelly, Rodney Scott
2011Beveridge NJ, Santarelli DMF, Tooney PA, Webster MJ, Weickert CS, Cairns MJ, 'Maturation of the human dorsolateral prefrontal cortex coincides with a dynamic shift in microRNA expression', The Proceedings of the First Scientific Meeting of Biological Psychiatry Australia, Melbourne, VIC (2011) [E3]
CitationsScopus - 2Web of Science - 2
Co-authorsMurray Cairns
2011Cairns MJ, Wu JQ, Tooney PA, Wang X, 'RNA-seq reveals significant alteration of cortical promoter usage and splicing in schizophrenia', The Proceedings of the First Scientific Meeting of Biological Psychiatry Australia, Melbourne, VIC (2011) [E3]
Co-authorsMurray Cairns
2011Gardiner EJ, Beveridge NJ, Liu B, Carr VJ, Scott R, Tooney PA, Cairns MJ, 'Gene expression profiling in peripheral blood mononuclear cells in schizophrenia', The Proceedings of the First Scientific Meeting of Biological Psychiatry Australia, Melbourne, VIC (2011) [E3]
Co-authorsMurray Cairns, Rodney Scott
2010Gardiner EJ, Beveridge NJ, Santarelli DMF, Wu JQ, Carr V, Scott R, et al., 'Mirna expression profiling in patients with schizophrenia', Australian & New Zealand Journal of Psychiatry, Sydney, NSW (2010) [E3]
Co-authorsRodney Scott, Murray Cairns
2010Gardiner E, Beveridge NJ, Santarelli D, Wu J, Carr V, Scott RJ, et al., 'MIRNA EXPRESSION PROFILING IN PATIENTS WITH SCHIZOPHRENIA', AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY (2010) [E3]
Author URL
Co-authorsRodney Scott, Murray Cairns
2010Carr V, Loughland C, McCabe K, Nasir A, Catts S, Jablensky A, et al., 'THE AUSTRALIAN SCHIZOPHRENIA RESEARCH BANK (ASRB): DEMOGRAPHIC, CLINICAL AND NEUROPSYCHOLOGICAL PROFILE OF PARTICIPANTS WITH SCHIZOPHRENIA', AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY (2010) [E3]
Author URL
Co-authorsFrans Henskens, Rodney Scott, Ulrich Schall
2010Beveridge NJ, Tooney PA, Webster M, Weickert CS, Cairns MJ, 'Microrna expression throughout postnatal development if the human dorsolateral prefrontal cortex', Australian & New Zealand Journal of Psychiatry, Sydney, Australia (2010) [E3]
Co-authorsMurray Cairns
2010Wu JQ, Cairns MJ, Scott R, Carr V, Mowry B, Jablensky A, et al., 'Genome wide analysis of DNA copy number in schizophrenia reveals loss of heterozygosity on chromosome 6P22.1 and 16P11.2-11.1', Australian & New Zealand Journal of Psychiatry, Sydney, Australia (2010) [E3]
Co-authorsUlrich Schall, Rodney Scott, Murray Cairns
2010Kumarasinghe N, Schall UA, Beveridge NJ, Gardiner EJ, Tooney PA, 'Gene expression analysis of treatment- naive schizophrenia patients', Australian & New Zealand Journal of Psychiatry, Sydney, Australia (2010) [E3]
Co-authorsUlrich Schall
2010Paulik G, Atkinson RJ, Carr V, Clark S, Curtis J, Langdon R, et al., 'Minds in transition (MINT): A prospective study examining neurocognitive correlates of transition from ultra-high risk mental state to schizophrenia', Australian & New Zealand Journal of Psychiatry, Sydney, NSW (2010) [E3]
Co-authorsJuanita Todd, Ulrich Schall, Carmel Loughland, Helen Stain, Pat Michie, Renate Thienel
2010Santarelli DMF, Beveridge NJ, Tooney PA, Cairns MJ, 'Upregulation of dicer and microrna expression in the dorsolateral prefrontal cortex (Brodmann's Area 46) in schizophrenia', Australian & New Zealand Journal of Psychiatry, Sydney, Australia (2010) [E3]
Co-authorsMurray Cairns
2009Cairns MJ, Beveridge NJ, Carroll AP, Gardiner EJ, Tooney PA, Santarelli DMF, 'Alteration of cortical microRNA biogenesis in schizophrenia and its influence on gene expression', XVIIth World Congress on Psychiatric Genetics: Abstract Book, San Diego, CA (2009) [E3]
Co-authorsMurray Cairns
2009Cairns MJ, Beveridge NJ, Carroll AP, Tooney PA, Gardiner EJ, Santarelli DMF, 'Alteration of microRNA biogenesis in schizophrenia and its implications for synaptic structure and function', Schizophrenia Bulletin, San Diego, CA (2009) [E3]
DOI10.1093/schbul/sbn173
Co-authorsMurray Cairns
2009Beveridge NJ, Carroll AP, Tooney PA, Cairns MJ, 'MicroRNA changes in the prefrontal and temporal cortices in schizophrenia', Schizophrenia Bulletin, San Diego, CA (2009) [E3]
DOI10.1093/schbul/sbn173
Co-authorsMurray Cairns
2008Rasser PE, Todd J, Thompson PM, Michie PT, Ward PB, Johnston P, et al., 'Linking cerebral grey matter and mismatch negativity (MMN) in schizophrenia', NeuroImage, Melbourne, VIC (2008) [E3]
Co-authorsUlrich Schall, Juanita Todd, Pat Michie
2008Beveridge NJ, Carroll AP, Tooney PA, Cairns MJ, 'Dysregulation of miRNA 181b in the temporal cortex in schizophrenia', 2008 Lorne Genome Conference Delegate Handbook, Lorne, VIC (2008) [E3]
Co-authorsMurray Cairns
2008Carroll AP, Beveridge NJ, Tooney PA, Cairns MJ, 'Identification of biologically relevant miRNA targets through the bidirectional modulation of miRNA expression', 2008 Lorne Genome Conference Delegate Handbook, Lorne, VIC (2008) [E3]
Co-authorsMurray Cairns
2008Beveridge NJ, Tooney PA, Carroll AP, Cairns MJ, 'MicroRNA changes in the cerebral cortex in schizophrenia', Proceedings of the Australian Society for Biochemistry and Molecular Biology, Canberra, ACT (2008) [E3]
Co-authorsMurray Cairns
2008Newall HD, Ward PB, Curtis J, Tooney PA, Henry C, Watkins A, O'Donnell M, '5HT2C gene polymorphisms, weight gain and metabolic syndrome in first episode psychosis', Australian and New Zealand Journal of Psychiatry, Newcastle, NSW (2008) [E3]
2008Gardiner EJ, Carroll AP, Beveridge NJ, Tooney PA, Cairns MJ, 'Investigation of miRNA influence on RGS4 and NRG1 gene expression in schizophrenia', Australian and New Zealand Journal of Psychiatry, Newcastle, NSW (2008) [E3]
Co-authorsMurray Cairns
2008Carroll AP, Beveridge NJ, Gardiner EJ, Tooney PA, Cairns MJ, 'Identification of biologically relevant, schizophrenia-associated MicroRNA targets', Australian and New Zealand Journal of Psychiatry, Newcastle, NSW (2008) [E3]
Co-authorsMurray Cairns
2008Beveridge NJ, Carroll AP, Gardiner EJ, Tooney PA, Cairns MJ, 'MicroRNA changes in the prefrontal and temporal cortices in schizophrenia', Australian and New Zealand Journal of Psychiatry, Newcastle, NSW (2008) [E3]
Co-authorsMurray Cairns
2008Henry C, Watkins A, O'Donnell M, Newall HD, Ward PB, Curtis J, Tooney PA, 'Gene polymorphisms, weight gain and metabolic syndrome in first episode psychosis', Australian and New Zealand Journal of Psychiatry, Newcastle, NSW (2008) [E3]
2008Schall UA, Rasser PE, Todd J, Michie PT, Ward PB, Johnston P, et al., 'A simple auditory event-related potential is linked to cerebral grey matter pathology in schizophrenia', Schizophrenia Research, Venice, Italy (2008) [E3]
DOI10.1016/s0920-9964(08)70347-5
Co-authorsJuanita Todd, Pat Michie, Ulrich Schall
2007Cairns MJ, Beveridge NJ, Carroll A, Scott R, Tooney PA, 'Investigation of post transcriptional gene silencing in schizophrenia', Schizophrenia Bulletin (Abstracts of the 11th International Congress on Schizophrenia Research), Colorado Springs, Colorado (2007) [E3]
Co-authorsRodney Scott, Murray Cairns
2007Tooney PA, Scott R, Cairns MJ, Bowden NA, 'Altered gene expression in the superior temporial gyrus in schizophrenia', Schizophrenia Bulletin (Abstracts of the 11th International Congress on Schizophrenia Research), Colorado Springs, Colorado (2007) [E3]
Co-authorsMurray Cairns, Rodney Scott, Nikola Bowden
2006Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Dysfunction of genes regulating membrane exocytosis in schizophrenia (Poster presentation)', Australian and New Zealand Journal of Psychiatry (Vol 40, noS2), Fremantle, Western Australia (2006) [E3]
Co-authorsRodney Scott, Judith Weidenhofer, Nikola Bowden
2005Russell SH, Loughland CM, Tooney PA, Scott R, Carr VJ, 'The Hunter DNA bank for schizophrenia and allied disorders: A unique Australian Resource facilitating genetic research into mental illness', Abstracts for The Royal Australian & NZ College of Psychiatrists Joint CINP/ASPR Scientific Meeting, Brisbane (2005) [E3]
Co-authorsRodney Scott, Carmel Loughland
2005Anderson WB, Tooney PA, Ross FB, 'Complexation of Cannabinoidergic and Serotonergic G Protein-Coupled Receptors', Proceedings of the 25th Annual 'Silver Jubilee' Meeting, Perth Convention Centre (2005) [E3]
2005Bowden NA, Weidenhofer JC, Scott R, Schall UA, Todd J, Michie PT, Tooney PA, 'Classification of schizophrenia using differential gene expression in peripheral blood lymphocytes', Human Genetics Society of Australasia, Newcastle (2005) [E3]
Co-authorsUlrich Schall, Rodney Scott, Judith Weidenhofer, Juanita Todd, Pat Michie, Nikola Bowden
2004Bowden NA, Weidenhofer JC, Scott R, Todd J, Case V, Schall UA, Tooney PA, 'Altered Expression of Brain Related Genes in Lymphocytes in Schizophrenia', American Journal of Medical Genetics, Ireland (2004) [E3]
DOI10.1002/ajmg.b.30101
Co-authorsJudith Weidenhofer, Juanita Todd, Rodney Scott, Nikola Bowden, Ulrich Schall
2004Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Gene Profiling in the Amygdala in Schizophrenia', American Journal of Medical Genetics, Ireland (2004) [E3]
Co-authorsJudith Weidenhofer, Rodney Scott, Nikola Bowden
2004Bowden NA, Weidenhofer JC, Scott R, Todd J, Case V, Schall UA, Tooney PA, 'Differental Gene Expression in Peripheral Blood Lymphocytes in Schizophrenia', Proceedings of the Australian Neuroscience Society, Melbourne (2004) [E3]
Co-authorsRodney Scott, Juanita Todd, Nikola Bowden, Ulrich Schall, Judith Weidenhofer
2004Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Altered Gene Expression Profiles in the Amygdala in Schizophrenia', Proceedings of the Australian Neuroscience Society, Melbourne (2004) [E3]
Co-authorsNikola Bowden, Judith Weidenhofer, Rodney Scott
2004Bowden NA, Weidenhofer JC, Scott R, Todd J, Case V, Schall UA, Tooney PA, 'Distinct Gene Expression Profiles due to Age in Schizophrenia', Proceedings of the Australian Neuroscience Society, Melbourne (2004) [E3]
Co-authorsJuanita Todd, Rodney Scott, Judith Weidenhofer, Nikola Bowden, Ulrich Schall
2000Tooney PA, Au GG, Chahl LA, 'Tachykinin NK1 and NK3 receptors in the prefrontal cortex of the human brain', Proceedings of the Australian Physiological and Pharmacological Society Symposium Tachykinins: The Challenge Continues, Newcastle, Australia (2000) [E1]
CitationsScopus - 27Web of Science - 26
Co-authorsGough Au
Show 41 more conferences
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Grants and Funding

Summary

Number of grants50
Total funding$6,414,647

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $22,000

Electrophysiology rig for the study of schizophrenia-related changes in white matter neurons after maternal infection$22,000

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding bodyRebecca L Cooper Medical Research Foundation Ltd
Project TeamAssociate Professor Paul Tooney, Doctor Phil Jobling, Doctor Brett Graham, Professor Deborah Hodgson, Emeritus Professor Patricia Michie, Doctor Lauren Harms
SchemeResearch Grant
RoleLead
Funding Start2015
Funding Finish2015
GNoG1400999
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20142 grants / $34,759

Genetic and Environmental Determinants of Depressive Symptoms: Trajectory and Outcomes in a Longitudinal Population Data Set$30,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Brian Kelly, Associate Professor Paul Tooney, Professor Rodney Scott, Professor John Attia, Conjoint Associate Professor Murray Cairns, Professor Vaughan Carr
SchemeProject Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1400594
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Neurobiological Investigation of Interstitial White Matter Neurons in a Maternal Infection Activation Model of Schizophrenia$4,759

Funding body: Australian Rotary Health

Funding bodyAustralian Rotary Health
Project TeamAssociate Professor Paul Tooney, Doctor Phil Jobling, Doctor Brett Graham
SchemeIan Scott Scholarship
RoleLead
Funding Start2014
Funding Finish2014
GNoG1301103
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20132 grants / $59,596

20122 grants / $40,000

Testing for N-methyl-D-aspartate (NMDA) receptor antibodies in a large Australian cohort of schizophrenia patients$30,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Paul Tooney, Mr Paul Rasser, Mr TIM Ehlkes, Emeritus Professor Patricia Michie, Professor Ulli Schall, Doctor Carmel Loughland
SchemeProject Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200854
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Testing for N-methyl-D-aspartate (NMDA) receptor antibodies in a large Australian cohort of schizophrenia patients$10,000

Funding body: Schizophrenia Research Institute

Funding bodySchizophrenia Research Institute
Project TeamAssociate Professor Paul Tooney, Associate Professor Ute Vollmer-Conna, Mr Paul Rasser, Mr TIM Ehlkes, Emeritus Professor Patricia Michie, Professor Ulli Schall, Doctor Carmel Loughland
SchemeResearch Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1201020
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20112 grants / $25,000

Emerging Research Leaders Program 2011$15,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Paul Tooney
SchemeEmerging Research Leaders Program
RoleLead
Funding Start2011
Funding Finish2011
GNoG1101112
Type Of FundingInternal
CategoryINTE
UONY

IMPLEN NanoPhotometer pearl$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Professor Alan Brichta, Emeritus Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Professor Ulli Schall, Associate Professor Phillip Dickson, Doctor Frederick Walker, Doctor Rick Thorne, Doctor Chris Dayas, Doctor Nikki Verrills, Doctor Janet Holt, Doctor Severine Roselli, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Associate Professor Liz Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Mr Dan Johnstone, Ms Belinda Goldie, Doctor Natalie Beveridge
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100030
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20107 grants / $1,174,215

Molecular and cellular characterisation of schizophrenia associated dysfunction in microRNA biogenesis$478,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Associate Professor Murray Cairns, Professor Rodney Scott, Associate Professor Paul Tooney, Emeritus Professor John Rostas, Professor Alan Brichta
SchemeProject Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG0190196
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Targeting neuroinflammation to improve the efficacy of antidepressant drugs$50,000

Funding body: BellBerry Limited

Funding bodyBellBerry Limited
Project TeamDoctor Frederick Walker, Dr Kathryn Buller, Associate Professor Paul Tooney
SchemeNear Miss
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG0900219
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

ABI 7500 Real Time PCR System $34,000

Funding body: NHMRC (National Health & Medical Research Council)

Analysis of schizophrenia-associated gene and mircoRNA signatures in purified CD4 and CD8 positive T-cells$25,000

Funding body: Hunter Children`s Research Foundation

Funding bodyHunter Children`s Research Foundation
Project TeamConjoint Associate Professor Murray Cairns, Doctor Jing Qin Wu, Associate Professor Paul Tooney, Professor Rodney Scott
SchemeResearch Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG0900188
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Do chiropractic spinal adjustments modulate brain derived neurotrophic factor levels in the brain - a study in the rodent$21,715

Funding body: Australian Spinal Research Foundation

Funding bodyAustralian Spinal Research Foundation
Project TeamAssociate Professor Philip Bolton, Associate Professor Paul Tooney
SchemeResearch Grant
RoleInvestigator
Funding Start2010
Funding Finish2010
GNoG0190387
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20094 grants / $580,928

Investigation of schizophrenia associated gene and miRNA expression in the dorsolateral prefrontal cortex$19,719

Funding body: Schizophrenia Research Institute

Funding bodySchizophrenia Research Institute
Project TeamConjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney
SchemePostgraduate Research Scholarship
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0190436
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Leica VT1200S - Fully automated vibrating blade microtome$16,209

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Robert Callister, Professor Alan Brichta, Conjoint Professor Keith Jones, Professor Jon Hirst, Doctor Brett Graham, Associate Professor Philip Bolton, Doctor Phil Jobling, Associate Professor Paul Tooney, Doctor Angela McPherson, Doctor Rebecca Lim, Doctor Ramatis De Oliveira, Mr Matthew Walsh
SchemeEquipment Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189842
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20085 grants / $2,522,000

Neuro-behavioural genetics network research program$2,400,000

Funding body: NSW Health

Funding bodyNSW Health
Project TeamConjoint Professor Vaughan Carr, Professor Rodney Scott, Associate Professor Paul Tooney, Professor Brian Kelly, Conjoint Associate Professor Murray Cairns
SchemeProject Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0189170
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Micro-array gene expression and grey matter changes in treatment - naive schizophrenia patients in Sri Lanka$56,000

Funding body: Schizophrenia Research Institute

Funding bodySchizophrenia Research Institute
Project TeamProfessor Ulli Schall, Associate Professor Paul Tooney
SchemePostgraduate Research Scholarship
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0189009
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

A road map of schizophrenia associated with gene and miRNA expression in the dorsolateral prefrontal cortex$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamConjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney
SchemeProject Grant
RoleInvestigator
Funding Start2008
Funding Finish2008
GNoG0188461
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Brain Science and Young People's Mental Health: A gene expression study in young people at ultra high risk of developing schizophrenia$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Paul Tooney, Emeritus Professor Patricia Michie, Professor Ulli Schall, Professor Rodney Scott, Associate Professor Helen Stain, Doctor Rebbekah Atkinson
SchemeProject Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188475
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Investigation of miRNA influence on NRG1 dysregulation in schizophrenia$16,000

Funding body: Schizophrenia Research Institute

Funding bodySchizophrenia Research Institute
Project TeamAssociate Professor Paul Tooney, Conjoint Associate Professor Murray Cairns
SchemePostgraduate Research Scholarship
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188594
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20075 grants / $208,702

HMRI Postdoctoral Fellowship in Youth Mental Health Research$150,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Ulli Schall, Emeritus Professor Patricia Michie, Associate Professor Paul Tooney, Associate Professor Helen Stain, Doctor Carmel Loughland, Conjoint Professor Vaughan Carr
SchemePostdoctoral Fellowship
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188274
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Gene silencing in the pathogenesis of schizophrenia$23,750

Funding body: Schizophrenia Research Institute

Funding bodySchizophrenia Research Institute
Project TeamAssociate Professor Paul Tooney, Conjoint Associate Professor Murray Cairns
SchemePostgraduate Research Scholarship
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187724
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

The functional characterization of schizophrenia-associated non-coding RNA expression$23,750

Funding body: Schizophrenia Research Institute

Funding bodySchizophrenia Research Institute
Project TeamAssociate Professor Paul Tooney, Conjoint Associate Professor Murray Cairns
SchemePostgraduate Research Scholarship
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187725
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

Investigation of Genetic and epigenetic mechanism underlying dysregulation of RGS4 in schizophrenia$8,702

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Paul Tooney, Conjoint Associate Professor Murray Cairns
SchemePilot Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187862
Type Of FundingInternal
CategoryINTE
UONY

International Congress on Schizphrenia Research, The Broadmoor, Colorado Sprins, Colorado, 28/3/2007 - 01/04/2007$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Paul Tooney
SchemeTravel Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187387
Type Of FundingInternal
CategoryINTE
UONY

20062 grants / $641,143

Investigation of miRNAs in schizophrenia$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Professor Rodney Scott
SchemePilot Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186685
Type Of FundingInternal
CategoryINTE
UONY

20052 grants / $326,689

Schizophrenia DNA Bank$119,500

Funding body: Australian Rotary Health

Funding bodyAustralian Rotary Health
Project Team
SchemeProject
RoleInvestigator
Funding Start2005
Funding Finish2006
GNo
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

20045 grants / $548,615

Senior research Officer Salary$246,800

Funding body: Schizoprhenia Research Institute (formerly NISAD)

Funding bodySchizoprhenia Research Institute (formerly NISAD)
Project Team
SchemeUnknown
RoleLead
Funding Start2004
Funding Finish2007
GNo
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Biacore3000-Expansion of Proteomics Facility$187,341

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Alistair Sim, Laureate Professor John Aitken, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Emeritus Professor Leonie Ashman, Professor Roger Smith, Professor Gordon Burns, Professor Adam McCluskey, Associate Professor Paul Tooney, Dr Fraser Ross, Conjoint Professor Ray Rose
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183030
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Analysis of gene expression in psychosis using microarray technology$93,474

 
Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project Team
SchemeBrain and Mental Health Reseacrh program Infrastructure funding
RoleLead
Funding Start2004
Funding Finish2006
GNo
Type Of FundingInternal
CategoryINTE
UONY

Investigation of the contribution of the use of cannabis in the development of schizophrenia in gentically predisposed individuals$16,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDr Fraser Ross, Associate Professor Paul Tooney
SchemeResearch Grant
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183754
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Investigation of the contribution of the use of cannabis in the development of schizophrenia in genetically predisposed individuals$5,000

Funding body: Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD)

Funding bodyNeuroscience Institute of Schizophrenia and Allied Disorders (NISAD)
Project Team
SchemeUnknown
RoleInvestigator
Funding Start2004
Funding Finish2004
GNo
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20032 grants / $26,000

DNA Bank for Schizophrenia Research$15,000

Funding body: The Percy Baxter Foundation

Funding bodyThe Percy Baxter Foundation
Project Team
SchemeUnknown
RoleLead
Funding Start2003
Funding Finish2003
GNo
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Assessment of somatosensory function in subjects with schizophrenia: touch, pain and axon reflex flare.$11,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Loris Chahl, Conjoint Professor Vaughan Carr, Associate Professor Paul Tooney, Doctor Carmel Loughland, Professor Mike Calford
SchemeProject Grant
RoleInvestigator
Funding Start2003
Funding Finish2003
GNoG0182466
Type Of FundingInternal
CategoryINTE
UONY

20025 grants / $165,000

The Genetics of Schizophrenia.$60,000

Funding body: Neuroscience Institute of Schizophrenia and Allied Disorders

Funding bodyNeuroscience Institute of Schizophrenia and Allied Disorders
Project TeamAssociate Professor Paul Tooney, Professor Rodney Scott
SchemePostgraduate Research Scholarship
RoleLead
Funding Start2002
Funding Finish2002
GNoG0182268
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

The role of tachykinins and their receptors in schizophrenia: An investigation at a cellular and genetic level.$60,000

Funding body: Neuroscience Institute of Schizophrenia and Allied Disorders

Funding bodyNeuroscience Institute of Schizophrenia and Allied Disorders
Project TeamAssociate Professor Paul Tooney, Conjoint Professor Loris Chahl, Professor Rodney Scott
SchemePostgraduate Research Scholarship
RoleLead
Funding Start2002
Funding Finish2002
GNoG0182269
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

The development of microarray technology for biomedical research in the Hunter Region.$21,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Paul Tooney, Doctor Douglas Dorahy, Professor Rodney Scott
SchemeResearch Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181184
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Equipment for the analysis of gene expression in psychosis using microarray technology$15,000

Funding body: Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD)

Funding bodyNeuroscience Institute of Schizophrenia and Allied Disorders (NISAD)
Project Team
SchemeUnknown
RoleLead
Funding Start2002
Funding Finish2002
GNo
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

The Effect of chronic treatment with a Tachykinin NK1 receptor antagonist on the stress response to opiod withdrawal in guinea-pigs$9,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Loris Chahl, Associate Professor Paul Tooney
SchemeProject Grant
RoleInvestigator
Funding Start2002
Funding Finish2002
GNoG0181266
Type Of FundingInternal
CategoryINTE
UONY

20012 grants / $11,500

Tachykinin NK, receptors in guinea-pig and human limbic systems: role in the response to stress$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamConjoint Professor Loris Chahl, Associate Professor Paul Tooney
SchemeProject Grant
RoleInvestigator
Funding Start2001
Funding Finish2001
GNoG0180106
Type Of FundingInternal
CategoryINTE
UONY

NK1 receptor immunoreactivity is increased in the prefrontal cortex in schizophrenia$1,500

Funding body: Ian Potter Foundation

Funding bodyIan Potter Foundation
Project Team
SchemePost-Doctoral Travel Grants
RoleLead
Funding Start2001
Funding Finish2001
GNo
Type Of FundingAust Competitive - Non Commonwealth
Category1NS
UONY

20002 grants / $28,500

Neurolucida Imaging System.$24,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Professor Loris Chahl, Associate Professor Paul Tooney, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas
SchemeEquipment Grant
RoleInvestigator
Funding Start2000
Funding Finish2000
GNoG0179167
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

The effects of anti-psychotic drugs on the distribution of tachykinin receptors in Guinea Pig brain.$4,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Paul Tooney
SchemeEarly Career Researcher Grant
RoleLead
Funding Start2000
Funding Finish2000
GNoG0179335
Type Of FundingInternal
CategoryINTE
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2014Investigation of White Matter Neurons in the Maternal Immune Activation Model of Schizophrenia
Pharmacy, Faculty of Health and Medicine
Principal Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2013Genomic Characterisation of Small RNA-Mediated Post-Transcriptional Gene Regulation
Pharmacy, Faculty of Health and Medicine
Co-Supervisor
2013Functional Analysis of Gene and microRNA Expression Profiling in Schizophrenia: Brain, Blood and Antipsychotics
Pharmacy, Faculty of Health and Medicine
Principal Supervisor
2013Post-Transcriptional Gene Regulation in Schizophrenia, Antipsychotic Drug Treatment and the Developing Brain
Pharmacy, Faculty of Health and Medicine
Co-Supervisor
2013Microarray Gene Expression and Cerebral Cortical Grey Matter Changes in Treatment Naive Schizophrenia Patients in Sri Lanka
Behavioural Science, Faculty of Health and Medicine
Co-Supervisor
2011Post-transcriptional Gene Silencing in Neuronal Differentiation, Development and Schizophrenia
Pharmacy, Faculty of Health and Medicine
Co-Supervisor
2010Cannabinoid Signaling Mechanisms in the Central Nervous System
Human Biology, Faculty of Health and Medicine
Co-Supervisor
2006Investigation of Cellular and Molecular Changes in the Amygdala in Schizophrenia
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2006Gene Expression Profiling in Schizophrenia
Health, Faculty of Health and Medicine
Co-Supervisor
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Associate Professor Paul Tooney

Position

Associate Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Pharmacy and Experimental Pharmacology

Contact Details

Emailpaul.tooney@newcastle.edu.au
Phone(02) 4921 8691
Fax(02) 492 17903

Office

RoomMS614
BuildingMedical Sciences
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
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