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Associate Professor Paul Tooney

Associate Professor

School of Biomedical Sciences and Pharmacy (Pharmacy and Experimental Pharmacology)

Brainstorming the brain

Associate Professor Paul Tooney regards his research into schizophrenia as one piece of a complex puzzle that spans many disciplines.

Paul Tooney speaking to a colleague 

Associate Professor Paul Tooney was undertaking postdoctoral cancer research in the United States when an opportunity to move to Newcastle to apply his cutting-edge skills in cellular and molecular biology to the study of schizophrenia changed the course of his career. Faced with the task of quickly familiarising himself with his new field, Tooney embarked on a self-styled orientation program that both schooled him in the fundamental aspects of the disorder and taught him much about the power of collaboration, a principle that has continued to guide his work.

"Many of my lab skills were transferrable but I really wanted to learn more about schizophrenia," Tooney recalls. "So, I attended clinical research seminars and grand rounds (case-study discussions) with doctors at the local mental health hospital and sat in on a brain anatomy course to enhance my knowledge of neuroscience.

"That allowed me to establish a rapport with many of the wonderful researchers and clinicians here from different disciplines working in the field of psychiatric illness. It became clear to me then that I could either sit in my silo and look exclusively at neurons in the brain or I could get out and see how my research could complement the work of others."

In 1998, Tooney moved to the University of Newcastle as a senior research officer supported by the Schizophrenia Research Institute (SRI), a University partner organisation. He received an academic appointment in 2004 and has since established an extensive collaborative network. Driven by the goal of developing a biological means of diagnosing schizophrenia and identifying new targets for drug discovery, his work draws on the expertise of colleagues in neuroscience, psychiatry, behavioural science, cell biology, genetics, bioinformatics and brain imaging.

Tooney was influential in establishing the Hunter DNA Bank for Schizophrenia and Allied Disorders, and later the nationwide Australian Schizophrenia Research Bank (ASRB) – the genetics arm of which is headquartered in Newcastle. The ASRB is a unique national database of comprehensive medical information collected uniformly from thousands of people, both with schizophrenia and without. Since the bank was launched in 2007, the information collected has been used in more than 65 research projects and over 35 scientific publications.

A strong focus of Tooney's interdisciplinary research is looking for possible subtypes of schizophrenia, using state-of-the-art technologies to study RNA and DNA molecules extracted from brain and peripheral tissue.

"When people are diagnosed with schizophrenia, we put them all into one basket but we know there are differences in the ways that people are affected, so it is likely that we actually have multiple disorders coming under this one diagnosis," Tooney explains. "I am striving to find a genetic basis for these subtypes, cross-referencing my research with patterns that psychologists and psychiatrists see in behaviour and cognition, so that we might be able to classify the disease better.

"Ultimately, if we can develop blood-based diagnostic tests that identify not only who has, or is likely to develop, schizophrenia but also what type of schizophrenia they have, then we might be able to improve our treatments, and in the process understand more about the disorder in general."

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Paul Tooney speaking to a colleague

Brainstorming the brain

Associate Professor Paul Tooney regards his research into schizophrenia as one piece of a complex puzzle that spans many disciplines.

Read more

Career Summary

Biography

Paul has a keen interest in understanding the cellular and molecular mechanisms of diseases, so that better diagnoses and treatment strategies can be developed. He completed a BSc (Hon) Class 1 (1985-1989) and a PhD (awarded 1995) from the University of Newcastle, Australia. He then travelled to the USA (1995-1998) and completed post-doctoral research at the University of Wisconsin. His research background during his PhD and postdoctoral work was in cancer biology where he gained experience in cellular and molecular biology techniques. In March 1998, Paul returned to Australia and took the opportunity to focus on the neurobiology of schizophrenia and joined the Schizophrenia Research Institute (formerly the Neuroscience Institute of Schizophrenia and Allied Disorders) as a Research Officer (1998-2000) and Senior Research Officer (2000-2004). In 2004, Paul was appointed to an academic position in the School of Biomedical Sciences and Pharmacy, Faculty of Health University of Newcastle.

Paul’s research from 1998 to date has focused on the neurobiology and genetics underpinning schizophrenia. He has conducted and collaborated on world-class studies detailing the changes to gene expression in the brain and also the blood from patients with schizophrenia. These studies showed that people with schizophrenia have distinct changes in their expression of genes in their brains and the blood. Interestingly many of these studies suggest changes in genes that have roles in the immune system and inflammatory processes/ As part of these efforts Paul played a major role in the establishment of the Australian Schizophrenia Research Bank (ASRB), which recruits participants with schizophrenia and controls and collects clinical and cognitive data as well as blood samples for genetic analysis and MRI structural brain scans from the participants. This huge data resource is currently being investigated by many groups to improve our understanding of what causes schizophrenia so that we can better identify who is likely to develop schizophrenia so that we can identify new treatments or preventative strategies for this devastating disorder.

More recently Paul established two new projects. One project is investigating why people with schizophrenia have more inhibitory interneurons in the white matter underneath the cortex of brain regions known to be affected in schizophrenia. The other project is investigating the levels of auto-antibodies directed against neuronal antigens in people with schizophrenia.

Research Expertise
Paul's research expertise is in cell and molecular biology. His research efforts during his PhD and postdoctoral training were directed at cancer biology using standard cell culture assays, immunofluorescnece labling of cultured cells, flow cytometry and molecular biology techniques. Since 1998, Paul has focused on the neurobiology of schizophrenia and has developed additional experience with molecular techniques to study gene expression changes in brain and blood samples. He also has experience in using immunolablelling techniques (immunofluorescence and immunohistochemistry) coupled with microscopy and cell counting to study changes in neurons in the brains of people with schizophrenia and in rodent models.

Teaching Expertise
Paul has expertise in teaching basic cell and molecular biology, pharmacology and coordinates a course on professional skills for biomedical science students. He has taught into the Biomedical Science, Medicine, Pharmacy, Nursing and Physiotherapy Programs.

Administrative Expertise
Paul was the B. Biomedical Science Program Convenor from 2008 to 2012

Collaborations
My current research interests are in the understanding of the neurobiology and genetics of schizophrenia so that better diagnoses and treatment strategies can be developed. Currently my research collaborations are around the following projects: 1. Investigation of the genetic basis of schizophrenia with the Neurobehavioural Genetics Unit 2. Investigation of the neurobiology and changes to interneurons in the white matter of the brain in schizophrenia. 3. Investigation of the level of autoantibodies directed against neuronal antigens in people with schizophrenia. 4. The Australian Schizophrenia Research Bank: http://www.schizophreniaresearch.org.au/bank/


Qualifications

  • PhD, University of Newcastle
  • Bachelor of Science, University of Newcastle
  • Bachelor of Science (Honours), University of Newcastle
  • Graduate Certificate Practice of Tertiary Teaching, University of Newcastle

Keywords

  • Biomedical Science
  • Cell Biology
  • Gene expression
  • Interneurons
  • Neurobiology
  • Pharmacology
  • Research Skills
  • Schizophrenia

Fields of Research

Code Description Percentage
060410 Neurogenetics 10
110319 Psychiatry (incl. Psychotherapy) 45
110999 Neurosciences not elsewhere classified 45

Professional Experience

UON Appointment

Title Organisation / Department
Associate Professor University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
1/07/2012 -  Associate Professor University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/2008 - 1/06/2012 Senior Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/07/2004 - 1/12/2007 Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/07/2000 - 1/07/2004 Senior Research Officer Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD)
Australia
1/03/1998 - 1/06/2000 Research Officer Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD)
Australia
1/03/1995 - 1/02/1998 Postdoctoral Research Associate

Cancer Biology

University of Wisconsin-Madison
Faculty of Medicine
United States
1/01/1990 - 1/12/1990 Research Assistant University of Newcastle
Faculty of Medicine
Australia

Membership

Dates Title Organisation / Department
Affiliated Scientist - Schizophrenia Research Institute Schizophrenia Research Institute
General Member - Australian Neuroscience Society Australian Neuroscience Society (ANS)
Australia

Awards

Research Award

Year Award
1991 Australian Postgraduate Research Award
University of Newcastle

Invitations

Participant

Year Title / Rationale
2001 Tachykinin NK1 receptor immunoreactivity is increased in the prefrontal cortex in schizophrenia
Organisation: International Congress On Schizophrenia Research Description: Invited to give oral presentation at International Congress On Schizophrenia Research in Canada 2001
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (45 outputs)

Year Citation Altmetrics Link
2014 Oldmeadow C, Mossman D, Evans TJ, Holliday EG, Tooney PA, Cairns MJ, et al., 'Combined analysis of exon splicing and genome wide polymorphism data predict schizophrenia risk loci.', J Psychiatr Res, 52 44-49 (2014) [C1]
DOI 10.1016/j.jpsychires.2014.01.011
Citations Scopus - 1Web of Science - 1
Co-authors John Attia, Murray Cairns, Rodney Scott, Liz Holliday, Christopher Oldmeadow
2014 McCarthy-Jones S, Green MJ, Scott RJ, Tooney PA, Cairns MJ, Wu JQ, et al., 'Preliminary evidence of an interaction between the FOXP2 gene and childhood emotional abuse predicting likelihood of auditory verbal hallucinations in schizophrenia', JOURNAL OF PSYCHIATRIC RESEARCH, 50 66-72 (2014) [C1]
DOI 10.1016/j.jpsychires.2013.11.012
Citations Scopus - 2Web of Science - 2
Co-authors Christopher Oldmeadow, Murray Cairns, Rodney Scott
2014 Green MJ, Chia T-Y, Cairns MJ, Wu J, Tooney PA, Scott RJ, Carr VJ, 'Catechol-O-methyltransferase (COMT) genotype moderates the effects of childhood trauma on cognition and symptoms in schizophrenia', Journal of Psychiatric Research, 49 43-50 (2014) [C1]

The interaction of genetic and environmental factors may affect the course and development of psychotic disorders. We examined whether the effects of childhood trauma on cognition... [more]

The interaction of genetic and environmental factors may affect the course and development of psychotic disorders. We examined whether the effects of childhood trauma on cognition and symptoms in schizophrenia were moderated by the Catechol-O-methyltransferase (COMT) Val158Met polymorphism, a common genetic variant known to affect cognition and prefrontal dopamine levels. Participants were 429 schizophrenia/schizoaffective cases from the Australian Schizophrenia Research Bank (ASRB). Cognitive performance was assessed using the Repeatable Battery for Assessment of Neuropsychological Status (RBANS), Controlled Oral Word Association Test (COWAT), Letter Number Sequencing (LNS) test, and the Wechsler Test of Adult Reading (WTAR). Hierarchical regression was used to test the main effects and additive interaction effects of genotype and childhood trauma in the domains of physical abuse, emotional abuse, and emotional neglect, on cognition and symptom profiles of clinical cases. Consistent with previous findings, COMT Val homozygotes performed worse on cognitive measures in the absence of childhood adversity. In addition, a significant interaction between COMT genotype and physical abuse was associated with better executive function in Val homozygotes, relative to those of the same genotype with no history of abuse. Finally, the severity of positive symptoms was greater in Met carriers who had experienced physical abuse, and the severity of negative symptoms in Met carriers was greater in the presence of emotional neglect. These results suggest that the possible epigenetic modulation of the expression of the COMT Val158Met polymorphism and consequent effects on cognition and symptoms in schizophrenia, with worse outcomes associated with adverse childhood experiences in Met carriers. © 2013 Elsevier Ltd.

DOI 10.1016/j.jpsychires.2013.10.018
Citations Scopus - 3Web of Science - 1
Co-authors Murray Cairns, Rodney Scott
2014 Green MJ, Chia T-Y, Carr VJ, Cairns MJ, Tooney PA, Scott RJ, Wu J, 'Catechol-O-methyltransferase (COMT) genotype moderates the effects of childhood trauma on cognition and symptoms in schizophrenia', Journal of Psychiatric Research, 49 43-50 (2014)
DOI 10.1016/j.jpsychires.2013.10.018
Co-authors Murray Cairns, Rodney Scott
2014 Kumarasinghe N, Rasser PE, Mendis J, Bergmann J, Knechtel L, Oxley S, et al., 'Age effects on cerebral grey matter and their associations with psychopathology, cognition and treatment response in previously untreated schizophrenia patients', Neurology Psychiatry and Brain Research, 20 29-36 (2014) [C1]
DOI 10.1016/j.npbr.2014.01.001
Co-authors Ulrich Schall
2014 Gardiner E, Carroll A, Tooney PA, Cairns MJ, 'Antipsychotic drug-associated gene-miRNA interaction in T-lymphocytes', International Journal of Neuropsychopharmacology, 17 929-943 (2014)
DOI 10.1017/S1461145713001752
Co-authors Murray Cairns
2014 Gardiner E, Carroll A, Tooney PA, Cairns MJ, 'Antipsychotic drug-associated gene-miRNA interaction in T-lymphocytes', International Journal of Neuropsychopharmacology, 17 929-943 (2014) [C1]

Antipsychotic drugs (APDs) can have a profound effect on the human body that extends well beyond our understanding of their neuropsychopharmacology. Some of these effects manifest... [more]

Antipsychotic drugs (APDs) can have a profound effect on the human body that extends well beyond our understanding of their neuropsychopharmacology. Some of these effects manifest themselves in peripheral blood lymphocytes, and in some cases, particularly in clozapine treatment, result in serious complications. To better understand the molecular biology of APD action in lymphocytes, we investigated the influence of chlorpromazine, haloperidol and clozapine in vitro, by microarray-based gene and microRNA (miRNA) expression analysis. JM-Jurkat T-lymphocytes were cultured in the presence of the APDs or vehicle alone over 2 wk to model the early effects of APDs on expression. Interestingly both haloperidol and clozapine appear to regulate the expression of a large number of genes. Functional analysis of APD-associated differential expression revealed changes in genes related to oxidative stress, metabolic disease and surprisingly also implicated pathways and biological processes associated with neurological disease consistent with current understanding of the activity of APDs. We also identified miRNA-mRNA interaction associated with metabolic pathways and cell death/survival, all which could have relevance to known side effects of APDs. These results indicate that APDs have a significant effect on expression in peripheral tissue that relate to both known mechanisms as well as poorly characterized side effects. © CINP 2014.

DOI 10.1017/S1461145713001752
Citations Scopus - 2Web of Science - 2
Co-authors Murray Cairns
2013 Carroll AP, Tooney PA, Cairns MJ, 'Design and interpretation of microRNA-reporter gene activity', Analytical Biochemistry, 437 164-171 (2013) [C1]

MicroRNAs (miRNAs) are small noncoding RNA molecules that act as sequence specificity guides to direct post-transcriptional gene silencing. In doing so, miRNAs regulate many criti... [more]

MicroRNAs (miRNAs) are small noncoding RNA molecules that act as sequence specificity guides to direct post-transcriptional gene silencing. In doing so, miRNAs regulate many critical developmental processes, including cellular proliferation, differentiation, migration, and apoptosis, as well as more specialized biological functions such as dendritic spine development and synaptogenesis. Interactions between miRNAs and their miRNA recognition elements occur via partial complementarity, rendering tremendous redundancy in targeting such that miRNAs are predicted to regulate 60% of the genome, with each miRNA estimated to regulate more than 200 genes. Because these predictions are prone to false positives and false negatives, there is an ever present need to provide material support to these assertions to firmly establish the biological function of specific miRNAs in both normal and pathophysiological contexts. Using schizophrenia-associated miR-181b as an example, we present detailed guidelines and novel insights for the rapid establishment of a streamlined miRNA-reporter gene assay and explore various design concepts for miRNA-reporter gene applications, including bidirectional miRNA modulation. In exemplifying this approach, we report seven novel miR-181b target sites for five schizophrenia candidate genes (DISC1, BDNF, ENKUR, GRIA1, and GRIK1) and dissect a number of vital concepts regarding future developments for miRNA-reporter gene assays and the interpretation of their results. © 2013 Elsevier Inc. All rights reserved.

DOI 10.1016/j.ab.2013.02.022
Citations Scopus - 4Web of Science - 3
Co-authors Murray Cairns
2013 Gardiner EJ, Cairns MJ, Liu B, Beveridge NJ, Carr V, Kelly B, et al., 'Gene expression analysis reveals schizophrenia-associated dysregulation of immune pathways in peripheral blood mononuclear cells', JOURNAL OF PSYCHIATRIC RESEARCH, 47 425-437 (2013) [C1]
DOI 10.1016/j.jpsychires.2012.11.007
Citations Scopus - 14Web of Science - 14
Co-authors Brian Kelly, Murray Cairns, Rodney Scott
2013 Santarelli DM, Liu B, Duncan CE, Beveridge NJ, Tooney PA, Schofield PR, Cairns MJ, 'Gene-microRNA interactions associated with antipsychotic mechanisms and the metabolic side effects of olanzapine', PSYCHOPHARMACOLOGY, 227 67-78 (2013) [C1]
DOI 10.1007/s00213-012-2939-y
Citations Scopus - 5Web of Science - 7
Co-authors Murray Cairns
2013 Green MJ, Cairns MJ, Wu J, Dragovic M, Jablensky A, Tooney PA, et al., 'Genome-wide supported variant MIR137 and severe negative symptoms predict membership of an impaired cognitive subtype of schizophrenia', MOLECULAR PSYCHIATRY, 18 774-780 (2013) [C1]
DOI 10.1038/mp.2012.84
Citations Scopus - 10Web of Science - 26
Co-authors Murray Cairns, Rodney Scott
2013 Green MJ, Cairns MJ, Wu J, Dragovic M, Jablensky A, Tooney PA, et al., 'Genome-wide supported variant MIR137 and severe negative symptoms predict membership of an impaired cognitive subtype of schizophrenia', Molecular Psychiatry, (2013) [C1]
DOI 10.1038/mp.2013.48
Citations Scopus - 21
2013 Kumarasinghe N, Beveridge NJ, Gardiner E, Scott RJ, Yasawardene S, Perera A, et al., 'Gene expression profiling in treatment-naive schizophrenia patients identifies abnormalities in biological pathways involving AKT1 that are corrected by antipsychotic medication', INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 16 1483-1503 (2013) [C1]
DOI 10.1017/S1461145713000035
Citations Scopus - 6Web of Science - 5
Co-authors Ulrich Schall, Rodney Scott
2013 Carroll AP, Tooney PA, Cairns MJ, 'Context-specific microRNA function in developmental complexity', Journal of Molecular Cell Biology, 5 73-84 (2013) [C1]

Since their discovery, microRNAs (miRNA) have been implicated in a vast array of biological processes in animals, from fundamental developmental functions including cellular proli... [more]

Since their discovery, microRNAs (miRNA) have been implicated in a vast array of biological processes in animals, from fundamental developmental functions including cellular proliferation and differentiation, to more complex and specialized roles such as long-term potentiation and synapse-specific modifications in neurons. This review recounts the history behind this paradigm shift, which has seen small non-coding RNA molecules coming to the forefront of molecular biology, and introduces their role in establishing developmental complexity in animals. The fundamental mechanisms of miRNA biogenesis and function are then considered, leading into a discussion of recent discoveries transforming our understanding of how these molecules regulate gene network behaviour throughout developmental and pathophysiological processes. The emerging complexity of this mechanism is also examined with respect to the influence of cellular context on miRNA function. This discussion highlights the absolute imperative for experimental designs to appreciate the significance of context-specific factors when determining what genes are regulated by a particular miRNA. Moreover, by establishing the timing, location, and mechanism of these regulatory events, we may ultimately understand the true biological function of a specific miRNA in a given cellular environment. © The Author (2013).

DOI 10.1093/jmcb/mjt004
Citations Scopus - 15Web of Science - 15
Co-authors Murray Cairns
2012 Kumarasinghe KMN, Tooney PA, Schall UA, 'Finding the needle in the haystack: A review of microarray gene expression research into schizophrenia', Australian and New Zealand Journal of Psychiatry, 46 598-610 (2012) [C1]
Citations Scopus - 12Web of Science - 11
Co-authors Ulrich Schall
2012 Gardiner EJ, Beveridge NJ, Wu JQ, Carr VJ, Scott R, Tooney PA, Cairns MJ, 'Imprinted DLK1-DIO3 region of 14q32 defines a schizophrenia-associated miRNA signature in peripheral blood mononuclear cells', Molecular Psychiatry, 17 827-840 (2012) [C1]
Citations Scopus - 57Web of Science - 52
Co-authors Rodney Scott, Murray Cairns
2012 Carroll AP, Tran N, Tooney PA, Cairns MJ, 'Alternative mRNA fates identified in microRNA-associated transcriptome analysis', BMC Genomics, 13 1-19 (2012) [C1]
Citations Scopus - 13Web of Science - 11
Co-authors Murray Cairns
2012 Wu JQ, Wang X, Beveridge NJ, Tooney PA, Scott R, Carr VJ, Cairns MJ, 'Transcriptome sequencing revealed significant alteration of cortical promoter usage and splicing in schizophrenia', PLoS One, 7 e36351 (2012) [C1]
Citations Scopus - 21Web of Science - 20
Co-authors Murray Cairns, Rodney Scott
2011 Santarelli DMF, Beveridge NJ, Tooney PA, Cairns MJ, 'Upregulation of dicer and MicroRNA expression in the dorsolateral prefrontal cortex Brodmann area 46 in schizophrenia', Biological Psychiatry, 69 180-187 (2011) [C1]
DOI 10.1016/j.biopsych.2010.09.030
Citations Scopus - 85Web of Science - 81
Co-authors Murray Cairns
2011 Case VS, Soyland A, Tooney PA, Thompson PM, Rasser PE, Schall UA, et al., 'Gray matter deficits, mismatch negativity, and outcomes in schizophrenia', Schizophrenia Bulletin, 37 131-140 (2011) [C1]
Citations Scopus - 54Web of Science - 50
Co-authors Ulrich Schall, Juanita Todd, Pat Michie
2010 Loughland CM, Draganic D, McCabe KL, Richards JM, Nasir MA, Allen J, et al., 'Australian Schizophrenia Research Bank: A database of comprehensive clinical, endophenotypic and genetic data for aetiological studies of schizophrenia', Australian and New Zealand Journal of Psychiatry, 44 1029-1035 (2010) [C1]
DOI 10.3109/00048674.2010.501758
Citations Web of Science - 19
Co-authors Pat Michie, Ulrich Schall, Rodney Scott, Carmel Loughland, Frans Henskens
2010 Beveridge NJ, Gardiner EJ, Carroll AP, Tooney PA, Cairns MJ, 'Schizophrenia is associated with an increase in cortical microRNA biogenesis', Molecular Psychiatry, 15 1176-1189 (2010) [C1]
DOI 10.1038/mp.2009.84
Citations Scopus - 147Web of Science - 119
Co-authors Murray Cairns
2009 Anderson WB, Graham BA, Beveridge NJ, Tooney PA, Brichta AM, Callister RJ, 'Different forms of glycine- and GABA(A)-receptor mediated inhibitory synaptic transmission in mouse superficial and deep dorsal horn neurons', Molecular Pain, 5 1-16 (2009) [C1]
DOI 10.1186/1744-8069-5-65
Citations Scopus - 8Web of Science - 7
Co-authors Brett Graham, Robert Callister, Alan Brichta
2009 Weidenhofer JC, Scott R, Tooney PA, 'Investigation of the expression of genes affecting cytomatrix active zone function in the amygdala in schizophrenia: Effects of antipsychotic drugs', Journal of Psychiatric Research, 43 282-290 (2009) [C1]
DOI 10.1016/j.jpsychires.2008.04.001
Citations Scopus - 7Web of Science - 6
Co-authors Judith Weidenhofer, Rodney Scott
2009 Beveridge NJ, Tooney PA, Carroll AP, Tran N, Cairns MJ, 'Down-regulation of miR-17 family expression in response to retinoic acid induced neuronal differentiation', Cellular Signalling, 21 1837-1845 (2009) [C1]
DOI 10.1016/j.cellsig.2009.07.019
Citations Scopus - 55Web of Science - 52
Co-authors Murray Cairns
2008 Bowden NA, Scott R, Tooney PA, 'Altered gene expression in the superior temporal gyrus in schizophrenia', BMC Genomics, 9 1-12 (2008) [C1]
DOI 10.1186/1471-2164-9-199
Citations Scopus - 32Web of Science - 32
Co-authors Rodney Scott, Nikola Bowden
2008 Beveridge NJ, Tooney PA, Carroll AP, Gardiner EJ, Bowden NA, Scott R, et al., 'Dysregulation of miRNA 181b in the temporal cortex in schizophrenia', Human Molecular Genetics, 17 1156-1168 (2008) [C1]
DOI 10.1093/hmg/ddn005
Citations Scopus - 168Web of Science - 162
Co-authors Murray Cairns, Rodney Scott, Nikola Bowden
2007 Bowden NA, Scott R, Tooney PA, 'Altered expression of regulator of G-protein signalling 4 (RGS4) mRNA in the superior temporal gyrus in schizophrenia', Schizophrenia Research, 89 165-168 (2007) [C1]
DOI 10.1016/j.schres.2006.09.003
Citations Scopus - 33Web of Science - 36
Co-authors Rodney Scott, Nikola Bowden
2006 Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Altered gene expression in the amygdala in schizophrenia: Up-regulation of genes located in the cytomatrix active zone', Molecular and Cellular Neuroscience, 31 243-250 (2006) [C1]
DOI 10.1016/j.mcn.2005.09.013
Citations Scopus - 35Web of Science - 34
Co-authors Rodney Scott, Judith Weidenhofer, Nikola Bowden
2006 Weidenhofer JC, Yip JR, Zavitsanou K, Huang XF, Chahl LA, Tooney PA, 'Immunohistochemical localisation of the NK1 receptor in the human amygdala: Preliminary investigation in schizophrenia', Progress in Neuro-Psychopharmacology and Biological Psychiatry, 30 1313-1321 (2006) [C1]
DOI 10.1016/j.pnpbp.2006.05.008
Citations Scopus - 6Web of Science - 5
Co-authors Judith Weidenhofer
2006 Bowden NA, Weidenhofer JC, Scott R, Schall U, Todd J, Michie PT, Tooney PA, 'Preliminary investigation of gene expression profiles in peripheral blood lymphocytes in schizophrenia', Schizophrenia Research, 82 175-183 (2006) [C1]
DOI 10.1016/j.schres.2005.11.012
Citations Scopus - 77Web of Science - 67
Co-authors Ulrich Schall, Nikola Bowden, Rodney Scott, Judith Weidenhofer, Juanita Todd, Pat Michie
2006 Bowden NA, Tooney PA, Scott R, 'Gene expression profiling of xeroderma pigmentosum', Hereditary Cancer in Clinical Practice, 4 103-110 (2006) [C1]
DOI 10.1186/1897-4287-4-2-103
Citations Scopus - 2
Co-authors Rodney Scott, Nikola Bowden
2006 Weidenhofer J, Bowden NA, Scott RJ, Tooney PA, 'Dysfunction of genes regulating membrane exocytosis in schizophrenia', AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY, 40 A129-A129 (2006)
Co-authors Nikola Bowden, Judith Weidenhofer, Rodney Scott
2005 Tooney PA, Anderson WB, Lynch-Frame AM, Chahl LA, 'The effects of haloperidol treatment on the distribution of NK1 receptor immunoreactive neurons in guinea-pig brain (Short Communication)', Neuroscience Letters, 383 155-159 (2005) [C1]
DOI 10.1016/j.neulet.2005.04.012
Citations Scopus - 4Web of Science - 4
2004 Tooney PA, Chahl LA, 'Neurons expressing calcium-binding proteins in the prefrontal cortex in schizophrenia', Progress in Neuro-Psychopharmacology & Biological Psychiatry, 28 273-278 (2004) [C1]
DOI 10.1016/j.pnpbp.2003.10.004
Citations Scopus - 26Web of Science - 24
2002 Tooney PA, Yip J, Zavitsanou K, Huang X-F, Chahl LA, 'Distribution of Tachykinin Receptors in the Human Amygdala', Proceedings of the Australian Neuroscience Society, 13 182 (2002) [C3]
2001 Tooney PA, Crawter VC, Chahl LA, 'Increased Tachykinin NK1 Receptor Immunoreactivity in the Prefrontal Cortex in Schizophrenia', Biological Psychiatry, 49 523-527 (2001) [C1]
Citations Scopus - 23Web of Science - 21
2001 Tooney PA, Crawter VC, Chahl LA, 'Tachykinin NK1 receptor immunoreactivity is increased in the prefrontal cortex in schizophrenia', SCHIZOPHRENIA RESEARCH, 49 64-64 (2001)
2000 Tooney PA, Au GG, Chahl LA, 'Localisation of tachykinin NK1 and NK3 receptors in the human prefrontal and visual cortex', Neuroscience Letters, 283 185-188 (2000) [C1]
Citations Scopus - 34Web of Science - 36
Co-authors Gough Au
1998 Tooney PA, Sakai T, Sakai K, Aeschlimann D, Mosher DF, 'Restricted localization of thrombospondin-2 protein during mouse embryogenesis: A comparison to thrombospondin-1', MATRIX BIOLOGY, 17 (2) 131-143 (1998) [C1]
Citations Scopus - 43Web of Science - 42
1993 AGREZ MV, TOONEY P, BURNS GF, 'SRC-RELATED PROTEIN TYROSINE KINASES ARE INVOLVED IN INTEGRIN-MEDIATED COLLAGEN REORGANIZATION BY FIBROBLASTS', JOURNAL OF CELLULAR BIOCHEMISTRY, 113-113 (1993)
1993 BURNS GF, TOONEY PA, MELDRUM CJ, 'GLYCOPROTEIN-88 (CD36) BINDS TUBULIN AND ENDOGENOUS THROMBOSPONDIN', JOURNAL OF CELLULAR BIOCHEMISTRY, 158-158 (1993)
1993 BURNS GF, TOONEY P, DENICHILO M, MELDRUM C, DORAHY D, 'THE BIOLOGY OF CD36 - AN INTEGRIN-ASSOCIATED ADHESION MOLECULE', JOURNAL OF LEUKOCYTE BIOLOGY, 109-109 (1993)
1993 Tooney P, Agrez MV, Burns GF, 'A re-examination of the molecular mechanism of cell movement', Immunology and Cell Biology, 71 131-139 (1993) [C1]
Citations Scopus - 16Web of Science - 19
1990 Smart YC, Tooney PA, Farrelly ML, Brien JH, Burton RC, 'Natural cytotoxic cells and tumour surveillance', European Journal of Cancer, 26 863-864 (1990) [C1]
Citations Scopus - 1Web of Science - 3
Show 42 more journal articles

Conference (44 outputs)

Year Citation Altmetrics Link
2015 Ibrahim EC, Bergon A, Belzeaux R, Comte M, Pelletier F, Herve M, et al., 'Transcriptome Analyses of Human Brain and Blood Tissues Converge to Dysregulated Expression of CX3CR1', BIOLOGICAL PSYCHIATRY, Toronto, CANADA (2015)
Co-authors Murray Cairns, Rodney Scott, Brian Kelly
2012 Gardiner EJ, Cairns MJ, Beveridge NJ, Liu B, Mossman D, Carr VJ, et al., 'Differential gene expression in peripheral blood mononuclear cells from a large cohort of participants with schizophrenia', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authors Murray Cairns, Rodney Scott
2012 Loughland CM, McCabe KL, Bridge JE, Henskens FA, Catts S, Jablensky A, et al., 'The Australian Schizophrenia Research Biobank (ASRB): An audit of the first five years of recruitment resource access', Schizophrenia Research, Florence, Italy (2012) [E3]
Co-authors Carmel Loughland, Frans Henskens, Pat Michie, Rodney Scott, Ulrich Schall
2012 Henskens FA, Paul DJ, Loughland CM, Bridge JE, McCabe KL, Catts S, et al., 'The Australian Schizophrenia Research Biobank (ASRB): IT development and management of a live e-research system', Schizophrenia Research, Florence, Italy (2012) [E3]
Co-authors Carmel Loughland, Ulrich Schall, Pat Michie, Frans Henskens
2012 Carroll AP, Tooney PA, Cairns MJ, 'Biological investigation of schizophrenia-associated miRNA dysregulation', Abstract Book. Biological Psychiatry Australia Scientific Meeting, Parkville, Vic (2012) [E3]
Co-authors Murray Cairns
2011 Wu J, Tooney PA, Wang X, Cairns MJ, 'Quantitative transcriptome sequencing reveals altered presynaptic vesicle trafficking and myelination in the temporal cortex in schizophrenia', Presentation Abstracts: XIXth World Congress of Psychiatric Genetics, Washington, DC (2011) [E3]
Co-authors Murray Cairns
2011 Loughland CM, McCabe KL, Catts S, Jablensky A, Henskens FA, Michie PT, et al., 'The Australian Schizophrenia Research Bank (ASRB): The first 550 schizophrenia sample profile', Schizophrenia Bulletin, Schizophrenia Bulletin (2011) [E3]
Co-authors Pat Michie, Rodney Scott, Ulrich Schall, Carmel Loughland, Frans Henskens
2011 Mossman D, Tooney PA, Cairns MJ, Kelly BJ, Carr V, Scott R, 'Identification of alternatively spliced gene variants in schizophrenia', Schizophrenia Bulletin, Colorado Springs, CO (2011) [E3]
Co-authors Murray Cairns, Brian Kelly, Rodney Scott
2011 Beveridge NJ, Santarelli DMF, Tooney PA, Webster MJ, Weickert CS, Cairns MJ, 'Maturation of the human dorsolateral prefrontal cortex coincides with a dynamic shift in microRNA expression', The Proceedings of the First Scientific Meeting of Biological Psychiatry Australia, Melbourne, VIC (2011) [E3]
Citations Scopus - 2Web of Science - 3
Co-authors Murray Cairns
2011 Cairns MJ, Wu JQ, Tooney PA, Wang X, 'RNA-seq reveals significant alteration of cortical promoter usage and splicing in schizophrenia', The Proceedings of the First Scientific Meeting of Biological Psychiatry Australia, Melbourne, VIC (2011) [E3]
Co-authors Murray Cairns
2011 Gardiner EJ, Beveridge NJ, Liu B, Carr VJ, Scott R, Tooney PA, Cairns MJ, 'Gene expression profiling in peripheral blood mononuclear cells in schizophrenia', The Proceedings of the First Scientific Meeting of Biological Psychiatry Australia, Melbourne, VIC (2011) [E3]
Co-authors Murray Cairns, Rodney Scott
2010 Gardiner EJ, Beveridge NJ, Santarelli DMF, Wu JQ, Carr V, Scott R, et al., 'Mirna expression profiling in patients with schizophrenia', Australian & New Zealand Journal of Psychiatry, Sydney, NSW (2010) [E3]
Co-authors Rodney Scott, Murray Cairns
2010 Gardiner E, Beveridge NJ, Santarelli D, Wu J, Carr V, Scott RJ, et al., 'MIRNA EXPRESSION PROFILING IN PATIENTS WITH SCHIZOPHRENIA', AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY (2010) [E3]
Co-authors Rodney Scott, Murray Cairns
2010 Carr V, Loughland C, McCabe K, Nasir A, Catts S, Jablensky A, et al., 'THE AUSTRALIAN SCHIZOPHRENIA RESEARCH BANK (ASRB): DEMOGRAPHIC, CLINICAL AND NEUROPSYCHOLOGICAL PROFILE OF PARTICIPANTS WITH SCHIZOPHRENIA', AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY (2010) [E3]
Co-authors Frans Henskens, Rodney Scott, Ulrich Schall
2010 Beveridge NJ, Tooney PA, Webster M, Weickert CS, Cairns MJ, 'Microrna expression throughout postnatal development if the human dorsolateral prefrontal cortex', Australian & New Zealand Journal of Psychiatry, Sydney, Australia (2010) [E3]
Co-authors Murray Cairns
2010 Wu JQ, Cairns MJ, Scott R, Carr V, Mowry B, Jablensky A, et al., 'Genome wide analysis of DNA copy number in schizophrenia reveals loss of heterozygosity on chromosome 6P22.1 and 16P11.2-11.1', Australian & New Zealand Journal of Psychiatry, Sydney, Australia (2010) [E3]
Co-authors Ulrich Schall, Rodney Scott, Murray Cairns
2010 Kumarasinghe N, Schall UA, Beveridge NJ, Gardiner EJ, Tooney PA, 'Gene expression analysis of treatment- naive schizophrenia patients', Australian & New Zealand Journal of Psychiatry, Sydney, Australia (2010) [E3]
Co-authors Ulrich Schall
2010 Paulik G, Atkinson RJ, Carr V, Clark S, Curtis J, Langdon R, et al., 'Minds in transition (MINT): A prospective study examining neurocognitive correlates of transition from ultra-high risk mental state to schizophrenia', Australian & New Zealand Journal of Psychiatry, Sydney, NSW (2010) [E3]
Co-authors Juanita Todd, Ulrich Schall, Carmel Loughland, Helen Stain, Pat Michie, Renate Thienel
2010 Santarelli DMF, Beveridge NJ, Tooney PA, Cairns MJ, 'Upregulation of dicer and microrna expression in the dorsolateral prefrontal cortex (Brodmann's Area 46) in schizophrenia', Australian & New Zealand Journal of Psychiatry, Sydney, Australia (2010) [E3]
Co-authors Murray Cairns
2009 Cairns MJ, Beveridge NJ, Carroll AP, Gardiner EJ, Tooney PA, Santarelli DMF, 'Alteration of cortical microRNA biogenesis in schizophrenia and its influence on gene expression', XVIIth World Congress on Psychiatric Genetics: Abstract Book, San Diego, CA (2009) [E3]
Co-authors Murray Cairns
2009 Cairns MJ, Beveridge NJ, Carroll AP, Tooney PA, Gardiner EJ, Santarelli DMF, 'Alteration of microRNA biogenesis in schizophrenia and its implications for synaptic structure and function', Schizophrenia Bulletin, San Diego, CA (2009) [E3]
DOI 10.1093/schbul/sbn173
Co-authors Murray Cairns
2009 Beveridge NJ, Carroll AP, Tooney PA, Cairns MJ, 'MicroRNA changes in the prefrontal and temporal cortices in schizophrenia', Schizophrenia Bulletin, San Diego, CA (2009) [E3]
DOI 10.1093/schbul/sbn173
Co-authors Murray Cairns
2008 Rasser PE, Todd J, Thompson PM, Michie PT, Ward PB, Johnston P, et al., 'Linking cerebral grey matter and mismatch negativity (MMN) in schizophrenia', NeuroImage, Melbourne, VIC (2008) [E3]
Co-authors Ulrich Schall, Juanita Todd, Pat Michie
2008 Beveridge NJ, Carroll AP, Tooney PA, Cairns MJ, 'Dysregulation of miRNA 181b in the temporal cortex in schizophrenia', 2008 Lorne Genome Conference Delegate Handbook, Lorne, VIC (2008) [E3]
Co-authors Murray Cairns
2008 Carroll AP, Beveridge NJ, Tooney PA, Cairns MJ, 'Identification of biologically relevant miRNA targets through the bidirectional modulation of miRNA expression', 2008 Lorne Genome Conference Delegate Handbook, Lorne, VIC (2008) [E3]
Co-authors Murray Cairns
2008 Beveridge NJ, Tooney PA, Carroll AP, Cairns MJ, 'MicroRNA changes in the cerebral cortex in schizophrenia', Proceedings of the Australian Society for Biochemistry and Molecular Biology, Canberra, ACT (2008) [E3]
Co-authors Murray Cairns
2008 Newall HD, Ward PB, Curtis J, Tooney PA, Henry C, Watkins A, O'Donnell M, '5HT2C gene polymorphisms, weight gain and metabolic syndrome in first episode psychosis', Australian and New Zealand Journal of Psychiatry, Newcastle, NSW (2008) [E3]
2008 Gardiner EJ, Carroll AP, Beveridge NJ, Tooney PA, Cairns MJ, 'Investigation of miRNA influence on RGS4 and NRG1 gene expression in schizophrenia', Australian and New Zealand Journal of Psychiatry, Newcastle, NSW (2008) [E3]
Co-authors Murray Cairns
2008 Carroll AP, Beveridge NJ, Gardiner EJ, Tooney PA, Cairns MJ, 'Identification of biologically relevant, schizophrenia-associated MicroRNA targets', Australian and New Zealand Journal of Psychiatry, Newcastle, NSW (2008) [E3]
Co-authors Murray Cairns
2008 Beveridge NJ, Carroll AP, Gardiner EJ, Tooney PA, Cairns MJ, 'MicroRNA changes in the prefrontal and temporal cortices in schizophrenia', Australian and New Zealand Journal of Psychiatry, Newcastle, NSW (2008) [E3]
Co-authors Murray Cairns
2008 Henry C, Watkins A, O'Donnell M, Newall HD, Ward PB, Curtis J, Tooney PA, 'Gene polymorphisms, weight gain and metabolic syndrome in first episode psychosis', Australian and New Zealand Journal of Psychiatry, Newcastle, NSW (2008) [E3]
2008 Schall UA, Rasser PE, Todd J, Michie PT, Ward PB, Johnston P, et al., 'A simple auditory event-related potential is linked to cerebral grey matter pathology in schizophrenia', Schizophrenia Research, Venice, Italy (2008) [E3]
DOI 10.1016/s0920-9964(08)70347-5
Co-authors Juanita Todd, Pat Michie, Ulrich Schall
2007 Cairns MJ, Beveridge NJ, Carroll A, Scott R, Tooney PA, 'Investigation of post transcriptional gene silencing in schizophrenia', Schizophrenia Bulletin (Abstracts of the 11th International Congress on Schizophrenia Research), Colorado Springs, Colorado (2007) [E3]
Co-authors Rodney Scott, Murray Cairns
2007 Tooney PA, Scott R, Cairns MJ, Bowden NA, 'Altered gene expression in the superior temporial gyrus in schizophrenia', Schizophrenia Bulletin (Abstracts of the 11th International Congress on Schizophrenia Research), Colorado Springs, Colorado (2007) [E3]
Co-authors Murray Cairns, Rodney Scott, Nikola Bowden
2006 Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Dysfunction of genes regulating membrane exocytosis in schizophrenia (Poster presentation)', Australian and New Zealand Journal of Psychiatry (Vol 40, noS2), Fremantle, Western Australia (2006) [E3]
Co-authors Rodney Scott, Judith Weidenhofer, Nikola Bowden
2005 Russell SH, Loughland CM, Tooney PA, Scott R, Carr VJ, 'The Hunter DNA bank for schizophrenia and allied disorders: A unique Australian Resource facilitating genetic research into mental illness', Abstracts for The Royal Australian & NZ College of Psychiatrists Joint CINP/ASPR Scientific Meeting, Brisbane (2005) [E3]
Co-authors Rodney Scott, Carmel Loughland
2005 Anderson WB, Tooney PA, Ross FB, 'Complexation of Cannabinoidergic and Serotonergic G Protein-Coupled Receptors', Proceedings of the 25th Annual 'Silver Jubilee' Meeting, Perth Convention Centre (2005) [E3]
2005 Bowden NA, Weidenhofer JC, Scott R, Schall UA, Todd J, Michie PT, Tooney PA, 'Classification of schizophrenia using differential gene expression in peripheral blood lymphocytes', Human Genetics Society of Australasia, Newcastle (2005) [E3]
Co-authors Ulrich Schall, Rodney Scott, Judith Weidenhofer, Juanita Todd, Pat Michie, Nikola Bowden
2004 Bowden NA, Weidenhofer JC, Scott R, Todd J, Case V, Schall UA, Tooney PA, 'Altered Expression of Brain Related Genes in Lymphocytes in Schizophrenia', American Journal of Medical Genetics, Ireland (2004) [E3]
DOI 10.1002/ajmg.b.30101
Co-authors Judith Weidenhofer, Juanita Todd, Rodney Scott, Nikola Bowden, Ulrich Schall
2004 Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Gene Profiling in the Amygdala in Schizophrenia', American Journal of Medical Genetics, Ireland (2004) [E3]
Co-authors Judith Weidenhofer, Rodney Scott, Nikola Bowden
2004 Bowden NA, Weidenhofer JC, Scott R, Todd J, Case V, Schall UA, Tooney PA, 'Differental Gene Expression in Peripheral Blood Lymphocytes in Schizophrenia', Proceedings of the Australian Neuroscience Society, Melbourne (2004) [E3]
Co-authors Rodney Scott, Juanita Todd, Nikola Bowden, Ulrich Schall, Judith Weidenhofer
2004 Weidenhofer JC, Bowden NA, Scott R, Tooney PA, 'Altered Gene Expression Profiles in the Amygdala in Schizophrenia', Proceedings of the Australian Neuroscience Society, Melbourne (2004) [E3]
Co-authors Nikola Bowden, Judith Weidenhofer, Rodney Scott
2004 Bowden NA, Weidenhofer JC, Scott R, Todd J, Case V, Schall UA, Tooney PA, 'Distinct Gene Expression Profiles due to Age in Schizophrenia', Proceedings of the Australian Neuroscience Society, Melbourne (2004) [E3]
Co-authors Juanita Todd, Rodney Scott, Judith Weidenhofer, Nikola Bowden, Ulrich Schall
2000 Tooney PA, Au GG, Chahl LA, 'Tachykinin NK1 and NK3 receptors in the prefrontal cortex of the human brain', Proceedings of the Australian Physiological and Pharmacological Society Symposium Tachykinins: The Challenge Continues, Newcastle, Australia (2000) [E1]
Citations Scopus - 27Web of Science - 26
Co-authors Gough Au
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Grants and Funding

Summary

Number of grants 50
Total funding $6,414,647

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $22,000

Electrophysiology rig for the study of schizophrenia-related changes in white matter neurons after maternal infection$22,000

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding body Rebecca L Cooper Medical Research Foundation Ltd
Project Team Associate Professor Paul Tooney, Doctor Phil Jobling, Doctor Brett Graham, Professor Deborah Hodgson, Emeritus Professor Patricia Michie, Doctor Lauren Harms
Scheme Research Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1400999
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20142 grants / $34,759

Genetic and Environmental Determinants of Depressive Symptoms: Trajectory and Outcomes in a Longitudinal Population Data Set$30,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Brian Kelly, Associate Professor Paul Tooney, Professor Rodney Scott, Professor John Attia, Conjoint Associate Professor Murray Cairns, Professor Vaughan Carr
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1400594
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Neurobiological Investigation of Interstitial White Matter Neurons in a Maternal Infection Activation Model of Schizophrenia$4,759

Funding body: Australian Rotary Health

Funding body Australian Rotary Health
Project Team Associate Professor Paul Tooney, Doctor Phil Jobling, Doctor Brett Graham
Scheme Ian Scott Scholarship
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1301103
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20132 grants / $59,596

20122 grants / $40,000

Testing for N-methyl-D-aspartate (NMDA) receptor antibodies in a large Australian cohort of schizophrenia patients$30,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Paul Tooney, Mr Paul Rasser, Mr TIM Ehlkes, Emeritus Professor Patricia Michie, Professor Ulli Schall, Doctor Carmel Loughland
Scheme Project Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200854
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Testing for N-methyl-D-aspartate (NMDA) receptor antibodies in a large Australian cohort of schizophrenia patients$10,000

Funding body: Schizophrenia Research Institute

Funding body Schizophrenia Research Institute
Project Team Associate Professor Paul Tooney, Associate Professor Ute Vollmer-Conna, Mr Paul Rasser, Mr TIM Ehlkes, Emeritus Professor Patricia Michie, Professor Ulli Schall, Doctor Carmel Loughland
Scheme Research Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1201020
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20112 grants / $25,000

Emerging Research Leaders Program 2011$15,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Paul Tooney
Scheme Emerging Research Leaders Program
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1101112
Type Of Funding Internal
Category INTE
UON Y

IMPLEN NanoPhotometer pearl$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Professor Alan Brichta, Emeritus Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Professor Ulli Schall, Associate Professor Phillip Dickson, Doctor Frederick Walker, Doctor Rick Thorne, Doctor Chris Dayas, Doctor Nikki Verrills, Doctor Janet Holt, Doctor Severine Roselli, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Associate Professor Liz Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Mr Dan Johnstone, Ms Belinda Goldie, Doctor Natalie Beveridge
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100030
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20107 grants / $1,174,215

Molecular and cellular characterisation of schizophrenia associated dysfunction in microRNA biogenesis$478,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Associate Professor Murray Cairns, Professor Rodney Scott, Associate Professor Paul Tooney, Emeritus Professor John Rostas, Professor Alan Brichta
Scheme Project Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0190196
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Laser microdissection microscopy system for cell and development biology$350,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Laureate Professor John Aitken, Associate Professor Brett Nixon, Doctor Shaun Roman, Professor Alan Brichta, Doctor Rick Thorne, Doctor Doug Smith, Associate Professor David McCurdy, Conjoint Professor Ray Rose, Professor Christopher Grof, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Doctor Brett Graham, Associate Professor Paul Tooney, Professor Roger Smith, Laureate Professor Paul Foster, Professor Trevor Day, Professor Robert Callister
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0190369
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Targeting neuroinflammation to improve the efficacy of antidepressant drugs$50,000

Funding body: BellBerry Limited

Funding body BellBerry Limited
Project Team Doctor Frederick Walker, Dr Kathryn Buller, Associate Professor Paul Tooney
Scheme Near Miss
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0900219
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

ABI 7500 Real Time PCR System $34,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Rick Thorne, Doctor Nikki Verrills, Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Doctor Doug Smith, Professor Gordon Burns, Emeritus Professor Leonie Ashman, Conjoint Professor Keith Jones, Doctor Charles De Bock, Doctor Chris Dayas, Doctor Brett Graham, Doctor Martin Horan, Doctor Rebecca Lim, Doctor Severine Roselli, Doctor Larisa Bobrovskaya, Doctor Kathryn Skelding, Doctor Frederick Walker, Doctor Jude Weidenhofer, Associate Professor Philip Bolton, Professor Alan Brichta, Professor Robert Callister, Professor Trevor Day, Associate Professor Phillip Dickson, Professor Manohar Garg, Doctor Phil Jobling, Associate Professor Derek Laver, Associate Professor Eugene Nalivaiko, Emeritus Professor John Rostas
Scheme Equipment Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000055
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Analysis of schizophrenia-associated gene and mircoRNA signatures in purified CD4 and CD8 positive T-cells$25,000

Funding body: Hunter Children`s Research Foundation

Funding body Hunter Children`s Research Foundation
Project Team Conjoint Associate Professor Murray Cairns, Doctor Jing Qin Wu, Associate Professor Paul Tooney, Professor Rodney Scott
Scheme Research Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0900188
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Do chiropractic spinal adjustments modulate brain derived neurotrophic factor levels in the brain - a study in the rodent$21,715

Funding body: Australian Spinal Research Foundation

Funding body Australian Spinal Research Foundation
Project Team Associate Professor Philip Bolton, Associate Professor Paul Tooney
Scheme Research Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0190387
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20094 grants / $580,928

Investigation of schizophrenia associated gene and miRNA expression in the dorsolateral prefrontal cortex$19,719

Funding body: Schizophrenia Research Institute

Funding body Schizophrenia Research Institute
Project Team Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney
Scheme Postgraduate Research Scholarship
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0190436
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Leica VT1200S - Fully automated vibrating blade microtome$16,209

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Robert Callister, Professor Alan Brichta, Conjoint Professor Keith Jones, Professor Jon Hirst, Doctor Brett Graham, Associate Professor Philip Bolton, Doctor Phil Jobling, Associate Professor Paul Tooney, Doctor Angela McPherson, Doctor Rebecca Lim, Doctor Ramatis De Oliveira, Mr Matthew Walsh
Scheme Equipment Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189842
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20085 grants / $2,522,000

Neuro-behavioural genetics network research program$2,400,000

Funding body: NSW Health

Funding body NSW Health
Project Team Conjoint Professor Vaughan Carr, Professor Rodney Scott, Associate Professor Paul Tooney, Professor Brian Kelly, Conjoint Associate Professor Murray Cairns
Scheme Project Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0189170
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Micro-array gene expression and grey matter changes in treatment - naive schizophrenia patients in Sri Lanka$56,000

Funding body: Schizophrenia Research Institute

Funding body Schizophrenia Research Institute
Project Team Professor Ulli Schall, Associate Professor Paul Tooney
Scheme Postgraduate Research Scholarship
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0189009
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

A road map of schizophrenia associated with gene and miRNA expression in the dorsolateral prefrontal cortex$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney
Scheme Project Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188461
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Brain Science and Young People's Mental Health: A gene expression study in young people at ultra high risk of developing schizophrenia$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Paul Tooney, Emeritus Professor Patricia Michie, Professor Ulli Schall, Professor Rodney Scott, Associate Professor Helen Stain, Doctor Rebbekah Atkinson
Scheme Project Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188475
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Investigation of miRNA influence on NRG1 dysregulation in schizophrenia$16,000

Funding body: Schizophrenia Research Institute

Funding body Schizophrenia Research Institute
Project Team Associate Professor Paul Tooney, Conjoint Associate Professor Murray Cairns
Scheme Postgraduate Research Scholarship
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188594
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20075 grants / $208,702

HMRI Postdoctoral Fellowship in Youth Mental Health Research$150,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Ulli Schall, Emeritus Professor Patricia Michie, Associate Professor Paul Tooney, Associate Professor Helen Stain, Doctor Carmel Loughland, Conjoint Professor Vaughan Carr
Scheme Postdoctoral Fellowship
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0188274
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Gene silencing in the pathogenesis of schizophrenia$23,750

Funding body: Schizophrenia Research Institute

Funding body Schizophrenia Research Institute
Project Team Associate Professor Paul Tooney, Conjoint Associate Professor Murray Cairns
Scheme Postgraduate Research Scholarship
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0187724
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

The functional characterization of schizophrenia-associated non-coding RNA expression$23,750

Funding body: Schizophrenia Research Institute

Funding body Schizophrenia Research Institute
Project Team Associate Professor Paul Tooney, Conjoint Associate Professor Murray Cairns
Scheme Postgraduate Research Scholarship
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0187725
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

Investigation of Genetic and epigenetic mechanism underlying dysregulation of RGS4 in schizophrenia$8,702

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Paul Tooney, Conjoint Associate Professor Murray Cairns
Scheme Pilot Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0187862
Type Of Funding Internal
Category INTE
UON Y

International Congress on Schizphrenia Research, The Broadmoor, Colorado Sprins, Colorado, 28/3/2007 - 01/04/2007$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Paul Tooney
Scheme Travel Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0187387
Type Of Funding Internal
Category INTE
UON Y

20062 grants / $641,143

Investigation of miRNAs in schizophrenia$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Professor Rodney Scott
Scheme Pilot Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186685
Type Of Funding Internal
Category INTE
UON Y

20052 grants / $326,689

Schizophrenia DNA Bank$119,500

Funding body: Australian Rotary Health

Funding body Australian Rotary Health
Project Team
Scheme Project
Role Investigator
Funding Start 2005
Funding Finish 2006
GNo
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

20045 grants / $548,615

Senior research Officer Salary$246,800

Funding body: Schizoprhenia Research Institute (formerly NISAD)

Funding body Schizoprhenia Research Institute (formerly NISAD)
Project Team
Scheme Unknown
Role Lead
Funding Start 2004
Funding Finish 2007
GNo
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Biacore3000-Expansion of Proteomics Facility$187,341

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Alistair Sim, Laureate Professor John Aitken, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Emeritus Professor Leonie Ashman, Professor Roger Smith, Professor Gordon Burns, Professor Adam McCluskey, Associate Professor Paul Tooney, Dr Fraser Ross, Conjoint Professor Ray Rose
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183030
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Analysis of gene expression in psychosis using microarray technology$93,474

 

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team
Scheme Brain and Mental Health Reseacrh program Infrastructure funding
Role Lead
Funding Start 2004
Funding Finish 2006
GNo
Type Of Funding Internal
Category INTE
UON Y

Investigation of the contribution of the use of cannabis in the development of schizophrenia in gentically predisposed individuals$16,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Dr Fraser Ross, Associate Professor Paul Tooney
Scheme Research Grant
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183754
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Investigation of the contribution of the use of cannabis in the development of schizophrenia in genetically predisposed individuals$5,000

Funding body: Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD)

Funding body Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD)
Project Team
Scheme Unknown
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20032 grants / $26,000

DNA Bank for Schizophrenia Research$15,000

Funding body: The Percy Baxter Foundation

Funding body The Percy Baxter Foundation
Project Team
Scheme Unknown
Role Lead
Funding Start 2003
Funding Finish 2003
GNo
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Assessment of somatosensory function in subjects with schizophrenia: touch, pain and axon reflex flare.$11,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Loris Chahl, Conjoint Professor Vaughan Carr, Associate Professor Paul Tooney, Doctor Carmel Loughland, Professor Mike Calford
Scheme Project Grant
Role Investigator
Funding Start 2003
Funding Finish 2003
GNo G0182466
Type Of Funding Internal
Category INTE
UON Y

20025 grants / $165,000

The Genetics of Schizophrenia.$60,000

Funding body: Neuroscience Institute of Schizophrenia and Allied Disorders

Funding body Neuroscience Institute of Schizophrenia and Allied Disorders
Project Team Associate Professor Paul Tooney, Professor Rodney Scott
Scheme Postgraduate Research Scholarship
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0182268
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

The role of tachykinins and their receptors in schizophrenia: An investigation at a cellular and genetic level.$60,000

Funding body: Neuroscience Institute of Schizophrenia and Allied Disorders

Funding body Neuroscience Institute of Schizophrenia and Allied Disorders
Project Team Associate Professor Paul Tooney, Conjoint Professor Loris Chahl, Professor Rodney Scott
Scheme Postgraduate Research Scholarship
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0182269
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

The development of microarray technology for biomedical research in the Hunter Region.$21,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Paul Tooney, Doctor Douglas Dorahy, Professor Rodney Scott
Scheme Research Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0181184
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Equipment for the analysis of gene expression in psychosis using microarray technology$15,000

Funding body: Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD)

Funding body Neuroscience Institute of Schizophrenia and Allied Disorders (NISAD)
Project Team
Scheme Unknown
Role Lead
Funding Start 2002
Funding Finish 2002
GNo
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

The Effect of chronic treatment with a Tachykinin NK1 receptor antagonist on the stress response to opiod withdrawal in guinea-pigs$9,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Loris Chahl, Associate Professor Paul Tooney
Scheme Project Grant
Role Investigator
Funding Start 2002
Funding Finish 2002
GNo G0181266
Type Of Funding Internal
Category INTE
UON Y

20012 grants / $11,500

Tachykinin NK, receptors in guinea-pig and human limbic systems: role in the response to stress$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Loris Chahl, Associate Professor Paul Tooney
Scheme Project Grant
Role Investigator
Funding Start 2001
Funding Finish 2001
GNo G0180106
Type Of Funding Internal
Category INTE
UON Y

NK1 receptor immunoreactivity is increased in the prefrontal cortex in schizophrenia$1,500

Funding body: Ian Potter Foundation

Funding body Ian Potter Foundation
Project Team
Scheme Post-Doctoral Travel Grants
Role Lead
Funding Start 2001
Funding Finish 2001
GNo
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

20002 grants / $28,500

Neurolucida Imaging System.$24,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Loris Chahl, Associate Professor Paul Tooney, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas
Scheme Equipment Grant
Role Investigator
Funding Start 2000
Funding Finish 2000
GNo G0179167
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The effects of anti-psychotic drugs on the distribution of tachykinin receptors in Guinea Pig brain.$4,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Paul Tooney
Scheme Early Career Researcher Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0179335
Type Of Funding Internal
Category INTE
UON Y
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Research Supervision

Current Supervision

Commenced Research Title / Program / Supervisor Type
2014 Investigation of White Matter Neurons in the Maternal Immune Activation Model of Schizophrenia
Pharmacy, Faculty of Health and Medicine
Principal Supervisor

Past Supervision

Year Research Title / Program / Supervisor Type
2013 Genomic Characterisation of Small RNA-Mediated Post-Transcriptional Gene Regulation
Pharmacy, Faculty of Health and Medicine
Co-Supervisor
2013 Functional Analysis of Gene and microRNA Expression Profiling in Schizophrenia: Brain, Blood and Antipsychotics
Pharmacy, Faculty of Health and Medicine
Principal Supervisor
2013 Post-Transcriptional Gene Regulation in Schizophrenia, Antipsychotic Drug Treatment and the Developing Brain
Pharmacy, Faculty of Health and Medicine
Co-Supervisor
2013 Microarray Gene Expression and Cerebral Cortical Grey Matter Changes in Treatment Naive Schizophrenia Patients in Sri Lanka
Behavioural Science, Faculty of Health and Medicine
Co-Supervisor
2011 Post-transcriptional Gene Silencing in Neuronal Differentiation, Development and Schizophrenia
Pharmacy, Faculty of Health and Medicine
Co-Supervisor
2010 Cannabinoid Signaling Mechanisms in the Central Nervous System
Human Biology, Faculty of Health and Medicine
Co-Supervisor
2006 Investigation of Cellular and Molecular Changes in the Amygdala in Schizophrenia
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2006 Gene Expression Profiling in Schizophrenia
Health, Faculty of Health and Medicine
Co-Supervisor
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Associate Professor Paul Tooney

Position

Associate Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Pharmacy and Experimental Pharmacology

Contact Details

Email paul.tooney@newcastle.edu.au
Phone (02) 4921 8691
Fax (02) 492 17903
Link UoN Blogs

Office

Room MS614
Building Medical Sciences
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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