Staff Profile
Associate Professor Phillip Dickson
Associate Professor
School of Biomedical Sciences and Pharmacy
EditCareer Summary
Qualifications
- PhD, University of Melbourne
- Bachelor of Science (Honours), University of Melbourne
Research
Research keywords
- Parkinson's disease
- catecholamines
- dopamine
- hierarchical phosphorylation
- signal transduction
- tyrosine hydroxylase
Research expertise
The focus of my work has been the enzyme tyrosine hydroxylase which controls the rate of synthesis of the catecholamines dopamine, noradrenaline and adrenaline. I have examined the control of tyrosine hydroxylase activity by phosphorylation and have shown that hierarchical phosphorylation(the phosphorylation one site affecting the rate of phosphorylation of another site on the same molecule) exists in tyrosine hydroxylase and plays an important role in the control of tyrosine hydroxylase activity. More recently my work has focused on how this regulation of tyrosine hydroxylase plays a role in Parkinson's disease. We have now found that there is a selective loss of one of the human TH isoforms in Parkinson's disease. Therefore the expression of particular TH isoforms may render the cells more susceptible to death in Parkinson's disease.
Fields of Research
| Code | Description | Percentage |
|---|
| 110199 | Medical Biochemistry And Metabolomics Not Elsewhere Classified | 40 |
| 060100 | Biochemistry And Cell Biology | 35 |
| 110900 | Neurosciences | 25 |
Invitations
13th International Symposium on Chromaffin Cell Biology International Society for Neurochemistry (ISN), Chile (Conference Presentation - non published.)
| 2006 |
Administrative
Administrative expertise
I was the foundation program coordinator for the Bachelor of Biomedical Sciences Honours program. Since 2004 I have been Head of the Discipline of Medical Biochemistry and in 2006 took up the position as the Research Higher Degrees Coordinator for the School of Biomedical Sciences. I have been a member of both the School Research Executive and the School Teaching Committee. In 2009 I was appointed Deputy Head of School in charge of infrastructure.
Teaching
Teaching keywords
- cellular biochemistry
- molecular biology
Teaching expertise
The focus of my teaching has been biochemistry and molecular biology. I have taught into the general areas of cell organelle structure, enzymology, cell communication and signal transduction, DNA replication, DNA transcription and protein synthesis and molecular biological techniques.
EditPublications
No publications.
EditGrants and Funding
Summary
| Number of grants | 36 |
|---|
| Total funding | $3,891,092 |
|---|
For project grants received where the lead institution is other than the University of Newcastle, details are shown in italics.
- Indicates that the researcher may be seeking students for this project.
Click on a grant title below to expand the full details for that specific grant.
2013 (3 grants)
Leica TP 1020 Automatic Tissue Processor for histology applications$35,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team |
|---|
| Doctor Pradeep Tanwar, Professor Eileen McLaughlin, Professor Xu Dong Zhang, Professor Robert Callister, Associate Professor Phillip Dickson, Professor Hubert Hondermarck, Doctor Jean-Marie Sontag, Professor Dirk Van Helden, Doctor Doug Smith, Doctor Phil Jobling, Associate Professor Estelle Sontag, Associate Professor Paul Tooney, Doctor Susan Hua, Doctor Janet Holt, Doctor Jay Horvat, Associate Professor Liz Milward, Professor Adam McCluskey, Associate Professor Brett Nixon, Doctor Rebecca Lim, Associate Professor Alan Brichta |
| Scheme | Role |
|---|
| Equipment Grant | Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $35,000 | 2013 | 2013 |
| GNo:G1201185 |
Ultra-Low Temperature Cryogenic Freezer$24,596
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team |
|---|
| Doctor Jude Weidenhofer, Doctor Rick Thorne, Doctor Kathryn Skelding, Doctor Nikki Verrills, Doctor Pradeep Tanwar, Associate Professor Phillip Dickson, Doctor Murray Cairns, Professor Hubert Hondermarck, Professor Xu Dong Zhang, Associate Professor Estelle Sontag, Doctor Chen Chen Jiang, Associate Professor Liz Milward, Doctor Jean-Marie Sontag, Associate Professor Paul Tooney, Doctor Severine Roselli, Doctor Matt Dun, Doctor Chris Dayas, Doctor Lin Kooi Ong, Professor Dirk Van Helden, Mr Ben Copeland, Ms Gabrielle Briggs, Conjoint Professor Leonie Ashman, Professor John Rostas |
| Scheme | Role |
|---|
| Equipment Grant | Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $24,596 | 2013 | 2013 |
| GNo:G1201189 |
42nd Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology, Brazil 18-21 May 13.$2,000
Funding Body: University of Newcastle - Faculty of Health
2012 (4 grants)
Human tyrosine hydroxylase isoforms and susceptibility of dopaminergic neurons to degeneration in Parkinson's disease$354,601
Funding Body: NHMRC (National Health & Medical Research Council)
Regulation of the cell cycle by phosphorylation dependent targeting of CaMKII$20,000
Funding Body: University of Newcastle
Role of CaMKII targeting in neuronal susceptibility to excitotoxic cell death$20,000
Funding Body: University of Newcastle
10th International catecholamine symposium, pacific Grove, California, 9 - 13 September 2012$1,862
Funding Body: University of Newcastle - Faculty of Health
2011 (1 grants)
IMPLEN NanoPhotometer pearl$10,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team |
|---|
| Doctor Murray Cairns, Associate Professor Paul Tooney, Associate Professor Alan Brichta, Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Professor Ulli Schall, Associate Professor Phillip Dickson, Doctor Frederick Walker, Doctor Rick Thorne, Doctor Chris Dayas, Doctor Nikki Verrills, Doctor Janet Holt, Doctor Severine Roselli, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Associate Professor Liz Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Mr Dan Johnstone, Ms Belinda Goldie, Ms Natalie Beveridge |
| Scheme | Role |
|---|
| Equipment Grant | Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $10,000 | 2011 | 2011 |
| GNo:G1100030 |
2010 (2 grants)
Repair of the nigrostriatal pathway by phenotype shift of dopamine neurones$60,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team |
|---|
| Associate Professor Phillip Dickson, Professor Malcolm Horne |
| Scheme | Role |
|---|
| Project Grant | Chief Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $60,000 | 2010 | 2012 |
| GNo:G1000068 |
ABI 7500 Real Time PCR System
$34,000
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team |
|---|
| Doctor Rick Thorne, Doctor Nikki Verrills, Doctor Murray Cairns, Associate Professor Paul Tooney, Doctor Doug Smith, Professor Gordon Burns, Conjoint Professor Leonie Ashman, Conjoint Professor Keith Jones, Doctor Charles De Bock, Doctor Chris Dayas, Doctor Brett Graham, Doctor Martin Horan, Doctor Rebecca Lim, Doctor Severine Roselli, Doctor Larisa Bobrovskaya, Doctor Kathryn Skelding, Doctor Frederick Walker, Doctor Jude Weidenhofer, Associate Professor Philip Bolton, Associate Professor Alan Brichta, Professor Robert Callister, Professor Trevor Day, Associate Professor Phillip Dickson, Professor Manohar Garg, Doctor Phil Jobling, Associate Professor Derek Laver, Associate Professor Eugene Nalivaiko, Professor John Rostas |
| Scheme | Role |
|---|
| Equipment Grant | Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $34,000 | 2010 | 2010 |
| GNo:G1000055 |
2009 (2 grants)
An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$495,000
Funding Body: ARC (Australian Research Council)
| Project Team |
|---|
| Laureate Professor John Aitken, Professor Adam McCluskey, Doctor Mark Baker, Doctor Nikki Verrills, Professor Marcel Maeder, Doctor Xiaojing Zhou, Professor Eileen McLaughlin, Associate Professor Brett Nixon, Doctor Shaun Roman, Conjoint Professor Ray Rose, Professor Hugh Dunstan, Professor Christopher Grof, Professor Roger Smith, Conjoint Professor Peter Gibson, Conjoint Professor Alison Jones, Professor Mike Calford, Conjoint Professor Keith Jones, Doctor Rick Thorne, Emeritus Professor Peter Dunkley, Professor Paul Foster, Conjoint Professor Leonie Ashman, Professor Gordon Burns, Associate Professor Phillip Dickson, Professor John Rostas, Professor Rodney Scott, Associate Professor Paul Tooney, Professor Phil Hansbro, Professor Pablo Moscato, Professor Paul Dastoor, Professor Peter Lewis |
| Scheme | Role |
|---|
| Linkage Infrastructure Equipment & Facilities (LIEF) | Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $495,000 | 2009 | 2009 |
| GNo:G0189122 |
An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$50,000
Funding Body: ARC (Australian Research Council)
| Project Team |
|---|
| Laureate Professor John Aitken, Professor Adam McCluskey, Doctor Mark Baker, Doctor Nikki Verrills, Professor Marcel Maeder, Doctor Xiaojing Zhou, Professor Eileen McLaughlin, Associate Professor Brett Nixon, Doctor Shaun Roman, Conjoint Professor Ray Rose, Professor Hugh Dunstan, Professor Christopher Grof, Professor Roger Smith, Conjoint Professor Peter Gibson, Conjoint Professor Alison Jones, Professor Mike Calford, Conjoint Professor Keith Jones, Doctor Rick Thorne, Emeritus Professor Peter Dunkley, Professor Paul Foster, Conjoint Professor Leonie Ashman, Professor Gordon Burns, Associate Professor Phillip Dickson, Professor John Rostas, Professor Rodney Scott, Associate Professor Paul Tooney, Professor Phil Hansbro, Professor Pablo Moscato, Professor Paul Dastoor, Professor Peter Lewis |
| Scheme | Role |
|---|
| Linkage Infrastructure Equipment & Facilities (LIEF) Partner funding | Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $50,000 | 2009 | 2009 |
| GNo:G0189948 |
2007 (2 grants)
Functional Characterisation of a New Regulatory Mechanism for CaMKII at Synapses in Vivo$526,500
Funding Body: NHMRC (National Health & Medical Research Council)
Differential regulation of human tyrosine hydroxylase isoforms and the development of Parkinson's disease$312,750
Funding Body: NHMRC (National Health & Medical Research Council)
2006 (4 grants)
PRC - Priority Research Centre for Bioinformatics, Biomarker Discovery & Information-Based Medicine (CIBM)$621,143
Funding Body: University of Newcastle
| Project Team |
|---|
| Professor Pablo Moscato, Professor Rodney Scott, Professor John Rostas, Professor John Forbes, Conjoint Professor Peter Hersey, Conjoint Professor Stephen Ackland, Conjoint Professor Wayne Smith, Emeritus Professor Peter Dunkley, Conjoint Professor Leonie Ashman, Professor John Attia, Associate Professor Phillip Dickson, Associate Professor Liz Milward, Professor Alistair Sim, Associate Professor Paul Tooney, Associate Professor Regina Berretta, Conjoint Professor David Sibbritt, Conjoint Professor Chris Levi, Professor Xu Dong Zhang, Conjoint Associate Professor Patricia Crock, Conjoint Associate Professor Jeannette Lechner-Scott |
| Scheme | Role |
|---|
| Priority Research Centre | Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $621,143 | 2006 | 2013 |
| GNo:G0186919 |
Functional Characterisation of CaMKII Phosphorylate at a New Site in vivo$20,000
Funding Body: University of Newcastle
Differential regulation of human tyrosine hydroxyase isoforms and susceptibility of dopaminergic neurons to degeneration$10,000
Funding Body: University of Newcastle
BioRad Mini-PROTEAN3 Electrophoresis system$995
Funding Body: Hunter Medical Research Institute
2005 (5 grants)
A novel mechanism for the maintenance of catecholamine synthesis$351,000
Funding Body: NHMRC (National Health & Medical Research Council)
High throughput proteomics - Thermo Finnigan ProteomeX LCQ Integrated Proteomicis Workstation$207,189
Funding Body: ARC (Australian Research Council)
| Project Team |
|---|
| Laureate Professor John Aitken, Professor Eileen McLaughlin, Professor Peter Lewis, Conjoint Associate Professor Renate Griffith, Conjoint Professor Ray Rose, Emeritus Professor John Patrick, Associate Professor David McCurdy, Professor Adam McCluskey, Emeritus Professor Ellak Von Nagy-Felsobuki, Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Professor John Rostas, Conjoint Professor Leonie Ashman, Professor Gordon Burns, Professor Paul Foster, Conjoint Professor Peter Gibson, Professor Roger Smith, Professor Alistair Sim, Associate Professor Paul Tooney, Dr Fraser Ross |
| Scheme | Role |
|---|
| Linkage Infrastructure Equipment & Facilities (LIEF) | Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $207,189 | 2005 | 2005 |
| GNo:G0184185 |
Control of Dopamine synthesis and Parkinsons' disease$10,000
Funding Body: Hunter Medical Research Institute
Regulation of Human Tyrosine Hydroxylase Isoforms by Hierarchical Phosphorylation$8,000
Funding Body: University of Newcastle
ISN 20th Biennial Meeting of the International Society for Neurochemistry, 21-26 August 2005$2,160
Funding Body: University of Newcastle
2004 (2 grants)
Biacore3000-Expansion of Proteomics Facility$187,341
Funding Body: ARC (Australian Research Council)
| Project Team |
|---|
| Professor Alistair Sim, Laureate Professor John Aitken, Emeritus Professor Peter Dunkley, Professor John Rostas, Associate Professor Phillip Dickson, Conjoint Professor Leonie Ashman, Professor Roger Smith, Professor Gordon Burns, Professor Adam McCluskey, Associate Professor Paul Tooney, Dr Fraser Ross, Conjoint Professor Ray Rose |
| Scheme | Role |
|---|
| Linkage Infrastructure Equipment & Facilities (LIEF) | Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $187,341 | 2004 | 2004 |
| GNo:G0183030 |
Wide Gel Format Western Blot Apparatus for the Medical Biochemistry Group$4,140
Funding Body: Hunter Medical Research Institute
2003 (2 grants)
Hierarchical Phosphorylation of Tyrosine Hydroxylase is Dependent on the Activation Sequence of Signaling Pathways.$135,000
Funding Body: ARC (Australian Research Council)
Dephosphorylation of tyrosine hydroxylase$11,000
Funding Body: University of Newcastle
2002 (4 grants)
Control of catecholamine synthesis and secretion by angiotensin II$270,000
Funding Body: NHMRC (National Health & Medical Research Council)
Peltier Thermal Cycler and associated equipment essential for establishing cDNA Retroviral Libraries$21,315
Funding Body: NHMRC (National Health & Medical Research Council)
Elucidation of the mechanism of tyrosine hydroxylase regulation by the use on mass spectrometry$12,000
Funding Body: University of Newcastle
Dephosphorylation of tyrosine hydroxylase in vitro and in vivo$11,000
Funding Body: University of Newcastle
| Project Team |
|---|
| Associate Professor Phillip Dickson, Dr Martin Cammarota |
| Scheme | Role |
|---|
| Project Grant | Chief Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $11,000 | 2002 | 2002 |
| GNo:G0181404 |
2001 (1 grants)
Control of Catecholamine Synthesis by Tyrosine Hydroxylase.$13,000
Funding Body: University of Newcastle
2000 (2 grants)
Control of Catecholamine Synthesis by Tyrosine Hydroxylase.$14,500
Funding Body: ARC (Australian Research Council)
Loss of control of dopamine synthesis and induction of neurodegeneration in Parkinson' Disease.$10,000
Funding Body: ARC (Australian Research Council)
| Project Team |
|---|
| Associate Professor Phillip Dickson, Conjoint Professor David Powis |
| Scheme | Role |
|---|
| Small Grant | Chief Investigator |
| Total Amount | Funding Start | Funding Finish |
|---|
| $10,000 | 2000 | 2000 |
| GNo:G0178912 |
1999 (2 grants)
FPLC Protein Purification System$16,000
Funding Body: NHMRC (National Health & Medical Research Council)
Development of a cellular model to study regulation of neurotransmitter synthesis$9,000
Funding Body: University of Newcastle
EditResearch Supervision
| Number of current supervisions | 1 |
|---|
| Total current UoN PhD EFTSL | 0.6 |
|---|
For supervisions undertaken at an institution other that the University of Newcastle, details are shown in italics, and the institution name is listed below the program name.
Current Supervision
| Commenced | Proposed Completion | Program | Supervisor Type | Research Title |
|---|
| 2011 | 2015 | PhD (Medical Biochemistry) | Principal Supervisor | The Interaction of Tyrosine Hydroxylase with Alpha Synuclein: a Role in Parkinson's Disease |
Past Supervision
| Year | Program | Supervisor Type | Research Title |
|---|
| 2013 | M Philosophy (Medical Biochem) | Co-Supervisor | Effects of Multi-site Phosphorylation on CaMKII Function |
| 2013 | PhD (Medical Biochemistry) | Principal Supervisor | Investigation of Catecholamine Inhibition in Tyrosine Hydroxylase |
| 2012 | PhD (Medical Biochemistry) | Co-Supervisor | Neurobiological Consequences of Stress: Tyrosine Hydroxylase Phosphorylation in Response to Stress |
| 2010 | PhD (Medical Biochemistry) | Principal Supervisor | Differential Distribution of Tyrosine Hydroxylase Isoforms and Phosphorylation in Parkinson Disease |
| 2009 | PhD (Medical Biochemistry) | Principal Supervisor | Acute Regulation of Tyrosine Hydroxylase |