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Career Summary

Qualifications

  • PhD, University of Melbourne
  • Bachelor of Science (Honours), University of Melbourne

Research

Research keywords

  • Parkinson's disease
  • catecholamines
  • dopamine
  • hierarchical phosphorylation
  • signal transduction
  • tyrosine hydroxylase

Research expertise

The focus of my work has been the enzyme tyrosine hydroxylase which controls the rate of synthesis of the catecholamines dopamine, noradrenaline and adrenaline. I have examined the control of tyrosine hydroxylase activity by phosphorylation and have shown that hierarchical phosphorylation(the phosphorylation one site affecting the rate of phosphorylation of another site on the same molecule) exists in tyrosine hydroxylase and plays an important role in the control of tyrosine hydroxylase activity. More recently my work has focused on how this regulation of tyrosine hydroxylase plays a role in Parkinson's disease. We have now found that there is a selective loss of one of the human TH isoforms in Parkinson's disease. Therefore the expression of particular TH isoforms may render the cells more susceptible to death in Parkinson's disease.

Fields of Research

CodeDescriptionPercentage
110199Medical Biochemistry And Metabolomics Not Elsewhere Classified40
060100Biochemistry And Cell Biology35
110900Neurosciences25

Invitations

13th International Symposium on Chromaffin Cell Biology
International Society for Neurochemistry (ISN), Chile (Conference Presentation - non published.)
2006

Administrative

Administrative expertise

I was the foundation program coordinator for the Bachelor of Biomedical Sciences Honours program. Since 2004 I have been Head of the Discipline of Medical Biochemistry and in 2006 took up the position as the Research Higher Degrees Coordinator for the School of Biomedical Sciences. I have been a member of both the School Research Executive and the School Teaching Committee. In 2009 I was appointed Deputy Head of School in charge of infrastructure.

Teaching

Teaching keywords

  • cellular biochemistry
  • molecular biology

Teaching expertise

The focus of my teaching has been biochemistry and molecular biology. I have taught into the general areas of cell organelle structure, enzymology, cell communication and signal transduction, DNA replication, DNA transcription and protein synthesis and molecular biological techniques.

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Publications

No publications.

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Grants and Funding

Summary

Number of grants36
Total funding$3,891,092

For project grants received where the lead institution is other than the University of Newcastle, details are shown in italics.

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2013 (3 grants)

Leica TP 1020 Automatic Tissue Processor for histology applications$35,000
Funding Body: NHMRC (National Health & Medical Research Council)

Ultra-Low Temperature Cryogenic Freezer$24,596
Funding Body: NHMRC (National Health & Medical Research Council)

42nd Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology, Brazil 18-21 May 13.$2,000
Funding Body: University of Newcastle - Faculty of Health

Project Team
Associate Professor Phillip Dickson
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,00020132013
GNo:G1300791

2012 (4 grants)

Human tyrosine hydroxylase isoforms and susceptibility of dopaminergic neurons to degeneration in Parkinson's disease$354,601
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Associate Professor Kay Double
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$354,60120122014
GNo:G1100113

Regulation of the cell cycle by phosphorylation dependent targeting of CaMKII$20,000
Funding Body: University of Newcastle

Project Team
Doctor Nikki Verrills, Doctor Kathryn Skelding, Professor John Rostas, Associate Professor Phillip Dickson, Conjoint Professor Keith Jones
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020122012
GNo:G1200679

Role of CaMKII targeting in neuronal susceptibility to excitotoxic cell death$20,000
Funding Body: University of Newcastle

Project Team
Professor John Rostas, Doctor Neil Spratt, Associate Professor Phillip Dickson, Doctor Nikki Verrills
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020122012
GNo:G1200673

10th International catecholamine symposium, pacific Grove, California, 9 - 13 September 2012$1,862
Funding Body: University of Newcastle - Faculty of Health

Project Team
Associate Professor Phillip Dickson
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,86220122013
GNo:G1200814

2011 (1 grants)

IMPLEN NanoPhotometer pearl$10,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Murray Cairns, Associate Professor Paul Tooney, Associate Professor Alan Brichta, Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Professor Ulli Schall, Associate Professor Phillip Dickson, Doctor Frederick Walker, Doctor Rick Thorne, Doctor Chris Dayas, Doctor Nikki Verrills, Doctor Janet Holt, Doctor Severine Roselli, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Associate Professor Liz Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Mr Dan Johnstone, Ms Belinda Goldie, Ms Natalie Beveridge
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$10,00020112011
GNo:G1100030

2010 (2 grants)

Repair of the nigrostriatal pathway by phenotype shift of dopamine neurones$60,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Phillip Dickson, Professor Malcolm Horne
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$60,00020102012
GNo:G1000068

ABI 7500 Real Time PCR System $34,000
Funding Body: NHMRC (National Health & Medical Research Council)

2009 (2 grants)

An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$495,000
Funding Body: ARC (Australian Research Council)

An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$50,000
Funding Body: ARC (Australian Research Council)

2007 (2 grants)

Functional Characterisation of a New Regulatory Mechanism for CaMKII at Synapses in Vivo$526,500
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor John Rostas, Associate Professor Phillip Dickson, Professor Alistair Sim
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$526,50020072009
GNo:G0186415

Differential regulation of human tyrosine hydroxylase isoforms and the development of Parkinson's disease$312,750
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Associate Professor Kay Double
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$312,75020072009
GNo:G0186394

2006 (4 grants)

PRC - Priority Research Centre for Bioinformatics, Biomarker Discovery & Information-Based Medicine (CIBM)$621,143
Funding Body: University of Newcastle

Project Team
Professor Pablo Moscato, Professor Rodney Scott, Professor John Rostas, Professor John Forbes, Conjoint Professor Peter Hersey, Conjoint Professor Stephen Ackland, Conjoint Professor Wayne Smith, Emeritus Professor Peter Dunkley, Conjoint Professor Leonie Ashman, Professor John Attia, Associate Professor Phillip Dickson, Associate Professor Liz Milward, Professor Alistair Sim, Associate Professor Paul Tooney, Associate Professor Regina Berretta, Conjoint Professor David Sibbritt, Conjoint Professor Chris Levi, Professor Xu Dong Zhang, Conjoint Associate Professor Patricia Crock, Conjoint Associate Professor Jeannette Lechner-Scott
SchemeRole
Priority Research CentreInvestigator
Total AmountFunding StartFunding Finish
$621,14320062013
GNo:G0186919

Functional Characterisation of CaMKII Phosphorylate at a New Site in vivo$20,000
Funding Body: University of Newcastle

Project Team
Professor John Rostas, Associate Professor Phillip Dickson, Professor Alistair Sim
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020062006
GNo:G0186059

Differential regulation of human tyrosine hydroxyase isoforms and susceptibility of dopaminergic neurons to degeneration$10,000
Funding Body: University of Newcastle

Project Team
Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Associate Professor Kay Double
SchemeRole
Near Miss GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00020062006
GNo:G0186079

BioRad Mini-PROTEAN3 Electrophoresis system$995
Funding Body: Hunter Medical Research Institute

Project Team
Conjoint Professor Leonie Ashman, Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Professor John Rostas, Professor Judith Scott, Professor Alistair Sim, Doctor Nikki Verrills
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$99520062006
GNo:G0187280

2005 (5 grants)

A novel mechanism for the maintenance of catecholamine synthesis$351,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$351,00020052007
GNo:G0184211

High throughput proteomics - Thermo Finnigan ProteomeX LCQ Integrated Proteomicis Workstation$207,189
Funding Body: ARC (Australian Research Council)

Control of Dopamine synthesis and Parkinsons' disease$10,000
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00020052005
GNo:G0185977

Regulation of Human Tyrosine Hydroxylase Isoforms by Hierarchical Phosphorylation$8,000
Funding Body: University of Newcastle

Project Team
Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$8,00020052005
GNo:G0184779

ISN 20th Biennial Meeting of the International Society for Neurochemistry, 21-26 August 2005$2,160
Funding Body: University of Newcastle

Project Team
Associate Professor Phillip Dickson
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,16020052005
GNo:G0185672

2004 (2 grants)

Biacore3000-Expansion of Proteomics Facility$187,341
Funding Body: ARC (Australian Research Council)

Project Team
Professor Alistair Sim, Laureate Professor John Aitken, Emeritus Professor Peter Dunkley, Professor John Rostas, Associate Professor Phillip Dickson, Conjoint Professor Leonie Ashman, Professor Roger Smith, Professor Gordon Burns, Professor Adam McCluskey, Associate Professor Paul Tooney, Dr Fraser Ross, Conjoint Professor Ray Rose
SchemeRole
Linkage Infrastructure Equipment & Facilities (LIEF)Investigator
Total AmountFunding StartFunding Finish
$187,34120042004
GNo:G0183030

Wide Gel Format Western Blot Apparatus for the Medical Biochemistry Group$4,140
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Phillip Dickson
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$4,14020042004
GNo:G0184540

2003 (2 grants)

Hierarchical Phosphorylation of Tyrosine Hydroxylase is Dependent on the Activation Sequence of Signaling Pathways.$135,000
Funding Body: ARC (Australian Research Council)

Project Team
Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeRole
Discovery ProjectsChief Investigator
Total AmountFunding StartFunding Finish
$135,00020032004
GNo:G0182096

Dephosphorylation of tyrosine hydroxylase$11,000
Funding Body: University of Newcastle

Project Team
Associate Professor Phillip Dickson
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$11,00020032003
GNo:G0182434

2002 (4 grants)

Control of catecholamine synthesis and secretion by angiotensin II$270,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$270,00020022004
GNo:G0180883

Peltier Thermal Cycler and associated equipment essential for establishing cDNA Retroviral Libraries$21,315
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Leonie Ashman, Dr Petranel Ferrao, Professor Gordon Burns, Professor Alistair Sim, Emeritus Professor Peter Dunkley, Professor John Rostas, Associate Professor Phillip Dickson, Professor Dirk Van Helden, Dr Perry Hartfield
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$21,31520022002
GNo:G0181919

Elucidation of the mechanism of tyrosine hydroxylase regulation by the use on mass spectrometry$12,000
Funding Body: University of Newcastle

Project Team
Associate Professor Phillip Dickson
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$12,00020022002
GNo:G0181403

Dephosphorylation of tyrosine hydroxylase in vitro and in vivo$11,000
Funding Body: University of Newcastle

Project Team
Associate Professor Phillip Dickson, Dr Martin Cammarota
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$11,00020022002
GNo:G0181404

2001 (1 grants)

Control of Catecholamine Synthesis by Tyrosine Hydroxylase.$13,000
Funding Body: University of Newcastle

Project Team
Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Emeritus Professor Ellak Von Nagy-Felsobuki, Professor Alistair Sim
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$13,00020012001
GNo:G0180125

2000 (2 grants)

Control of Catecholamine Synthesis by Tyrosine Hydroxylase.$14,500
Funding Body: ARC (Australian Research Council)

Project Team
Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Emeritus Professor Ellak Von Nagy-Felsobuki
SchemeRole
Small GrantInvestigator
Total AmountFunding StartFunding Finish
$14,50020002000
GNo:G0178980

Loss of control of dopamine synthesis and induction of neurodegeneration in Parkinson' Disease.$10,000
Funding Body: ARC (Australian Research Council)

Project Team
Associate Professor Phillip Dickson, Conjoint Professor David Powis
SchemeRole
Small GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00020002000
GNo:G0178912

1999 (2 grants)

FPLC Protein Purification System$16,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Alistair Sim, Professor John Rostas, Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$16,00019991999
GNo:G0180790

Development of a cellular model to study regulation of neurotransmitter synthesis$9,000
Funding Body: University of Newcastle

Project Team
Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$9,00019991999
GNo:G0178050
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Research Supervision

Number of current supervisions1
Total current UoN PhD EFTSL0.6

For supervisions undertaken at an institution other that the University of Newcastle, details are shown in italics, and the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20112015PhD (Medical Biochemistry)Principal SupervisorThe Interaction of Tyrosine Hydroxylase with Alpha Synuclein: a Role in Parkinson's Disease

Past Supervision

YearProgramSupervisor TypeResearch Title
2013M Philosophy (Medical Biochem)Co-SupervisorEffects of Multi-site Phosphorylation on CaMKII Function
2013PhD (Medical Biochemistry)Principal SupervisorInvestigation of Catecholamine Inhibition in Tyrosine Hydroxylase
2012PhD (Medical Biochemistry)Co-SupervisorNeurobiological Consequences of Stress: Tyrosine Hydroxylase Phosphorylation in Response to Stress
2010PhD (Medical Biochemistry)Principal SupervisorDifferential Distribution of Tyrosine Hydroxylase Isoforms and Phosphorylation in Parkinson Disease
2009PhD (Medical Biochemistry)Principal SupervisorAcute Regulation of Tyrosine Hydroxylase
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Associate Professor Phillip Dickson

Work Phone(02) 4921 7031
Fax(02) 4921 6903
Email
PositionAssociate Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaMedical Biochemistry
Office
LS3-47,
Life Sciences Building,
Callaghan
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/phil-dickson