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Associate Professor Phillip Dickson

Associate Professor

School of Biomedical Sciences and Pharmacy (Medical Biochemistry)

Career Summary

Qualifications

  • PhD, University of Melbourne
  • Bachelor of Science (Honours), University of Melbourne

Keywords

  • Parkinson's disease
  • catecholamines
  • cellular biochemistry
  • dopamine
  • hierarchical phosphorylation
  • molecular biology
  • signal transduction
  • tyrosine hydroxylase

Fields of Research

CodeDescriptionPercentage
110199Medical Biochemistry and Metabolomics not elsewhere classified40
060199Biochemistry and Cell Biology not elsewhere classified35
110999Neurosciences not elsewhere classified25

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2014 - Associate ProfessorUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Invitations

Participant

YearTitle / Rationale
200613th International Symposium on Chromaffin Cell Biology
Organisation: International Society for Neurochemistry (ISN) Description: Invited speaker to the conference
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

YearCitationAltmetricsLink
2013Dickson PW, Briggs GD, 'Tyrosine hydroxylase. Regulation by feedback inhibition and phosphorylation.', Advances in Pharmacology: A New Era of Catecholamines in the Laboratory and Clinic, Academic Press, San Diego 13-21 (2013) [B1]
DOI10.1016/B978-0-12-411512-5.00002-6
CitationsScopus - 2

Journal article (45 outputs)

YearCitationAltmetricsLink
2015Quinn RK, Brown AL, Goldie BJ, Levi EM, Dickson PW, Smith DW, et al., 'Distinct miRNA expression in dorsal striatal subregions is associated with risk for addiction in rats.', Transl Psychiatry, 5 e503 (2015)
DOI10.1038/tp.2014.144Author URL
Co-authorsMurray Cairns, Christopher Dayas
2014James MH, Quinn RK, Ong LK, Levi EM, Charnley JL, Smith DW, et al., 'mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIa levels.', Neuropsychopharmacology, 39 1694-1702 (2014) [C1]
DOI10.1038/npp.2014.16Author URL
CitationsScopus - 1
Co-authorsChristopher Dayas, Douglas Smith, Linkooi Ong
2014Briggs GD, Bulley J, Dickson PW, 'Catalytic domain surface residues mediating catecholamine inhibition in tyrosine hydroxylase', Journal of Biochemistry, 155 183-193 (2014) [C1]
DOI10.1093/jb/mvt110
2014Ong LK, Guan L, Damanhuri H, Goodchild AK, Bobrovskaya L, Dickson PW, Dunkley PR, 'Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla', JOURNAL OF NEUROCHEMISTRY, 128 547-560 (2014) [C1]
DOI10.1111/jnc.12482Author URL
CitationsScopus - 2Web of Science - 1
Co-authorsPeter Dunkley, Linkooi Ong
2014Stutz B, Lima da Conceicao FS, Santos LE, Cadilhe DV, Fleming RL, Acquarone M, et al., 'Murine dopaminergic Muller cells restore motor function in a model of Parkinson's disease', JOURNAL OF NEUROCHEMISTRY, 128 829-840 (2014) [C1]
DOI10.1111/jnc.12475Author URL
CitationsScopus - 2Web of Science - 2
Co-authorsPeter Dunkley
2014Hoffman A, Carpenter H, Kahl R, Watt LF, Dickson PW, Rostas JAP, et al., 'Dephosphorylation of CaMKII at T253 controls the metaphase-anaphase transition', Cellular Signalling, 26 748-756 (2014) [C1]

Calcium/calmodulin-stimulated protein kinase II (CaMKII) is a multi-functional serine/threonine protein kinase that controls a range of cellular functions, including proliferation. The biological properties of CaMKII are regulated by multi-site phosphorylation and targeting via interactions with specific proteins. To investigate the role specific CaMKII phosphorylation sites play in controlling cell proliferation and cell cycle progression, we examined phosphorylation of CaMKII at two sites (T253 and T286) at various stages of the cell cycle, and also examined the effects of overexpression of wild-type (WT), T286D phosphomimic, T253D phosphomimic and T253V phosphonull forms of CaMKIIa in MDA-MB-231 breast cancer and SHSY5Y neuroblastoma cells on cellular proliferation and cell cycle progression. We demonstrate herein that whilst there is no change in total CaMKII expression or T286 phosphorylation throughout the cell cycle, a marked dephosphorylation of CaMKII at T253 occurs during the G2 and/or M phases. Additionally, we show by molecular inhibition, as well as pharmacological activation, that protein phosphatase 2A (PP2A) is the phosphatase responsible for this dephosphorylation. Furthermore, we show that inducible overexpression of WT, T286D and T253V forms of CaMKIIa in MDA-MB-231 and SHSY5Y cells increases cellular proliferation, with no alteration in cell cycle profiles. By contrast, overexpression of a T253D phosphomimic form of CaMKIIa significantly decreases proliferation, and cells accumulate in mitosis, specifically in metaphase. Taken together, these results strongly suggest that the dephosphorylation of CaMKII at T253 is involved in controlling the cell cycle, specifically the metaphase-anaphase transition. © 2014 Elsevier Inc.

DOI10.1016/j.cellsig.2013.12.015
CitationsScopus - 1Web of Science - 1
Co-authorsKathryn Skelding, John Rostas, Nikki Verrills
2014Abdul Majeed ABB, Pearsall E, Carpenter H, Brzozowski J, Dickson PW, Rostas JAP, Skelding KA, 'CaMKII Kinase Activity, Targeting and Control of Cellular Functions: Effect of Single and Double Phosphorylation of CaMKIIa', Calcium Signaling, 1 36-51 (2014) [C1]
Co-authorsKathryn Skelding, John Rostas
2013Briggs G, Bulley J, Dunkley PR, Dickson PW, 'Structural Basis for Regulation of Tyrosine Hydroxlyase by the Catecholamines 8-9 (2013) [E3]
DOI10.1016/B978-0-12-800044-1.00006-4
Co-authorsPeter Dunkley
2013Briggs GD, Nagy GM, Dickson PW, 'Mechanism of action of salsolinol on tyrosine hydroxylase', Neurochemistry International, 63 726-731 (2013) [C1]

Tyrosine hydroxylase (TH) is the first and rate-limiting enzyme in dopamine synthesis. Dopamine regulates TH as an end-product inhibitor through its binding to a high and low affinity site, the former being abolished by Ser40 phosphorylation only, and the latter able to bind and dissociate according to intracellular dopamine levels. Here, we have investigated TH inhibition by a dopamine metabolite found in dopaminergic brain regions, salsolinol (SAL). SAL is known to decrease dopamine in the nigrostriatal pathway and mediobasal hypothalamus, and to also decrease plasma catecholamines in rat stress models, however a target and mechanism for the effects of SAL have not been found. We found that SAL inhibits TH activity in the nanomolar range in vitro, by binding to both the high and low affinity dopamine binding sites. SAL produces the same level of inhibition as dopamine when TH is non-phosphorylated. However, it produces 3.7-fold greater inhibition of Ser40-phosphorylated TH compared to dopamine by competing more strongly with tetrahydrobiopterin, the cofactor of this enzymatic reaction. SAL's potent inhibition of phosphorylated TH would prevent TH from being fully activated to synthesise dopamine. Crown Copyright © 2013 Published by Elsevier Ltd. All rights reserved.

DOI10.1016/j.neuint.2013.09.016
CitationsScopus - 2Web of Science - 1
2013Sominsky L, Fuller EA, Bondarenko E, Ong LK, Averell L, Nalivaiko E, et al., 'Functional Programming of the Autonomic Nervous System by Early Life Immune Exposure: Implications for Anxiety', PLOS ONE, 8 (2013) [C1]
DOI10.1371/journal.pone.0057700Author URL
CitationsScopus - 9Web of Science - 10
Co-authorsDeborah Hodgson, Peter Dunkley, Eugene Nalivaiko, Linkooi Ong
2012Skelding KA, Dickson PW, Verrills NM, Rostas JA, 'Progression through mitosis can be controlled by dephosphorylation of CaMKII at T253', JOURNAL OF NEUROCHEMISTRY, 123 31-31 (2012) [E3]
Author URL
Co-authorsNikki Verrills, John Rostas, Kathryn Skelding
2012Majeed ABA, Rostas JAP, Carpenter H, Dickson PW, Skelding KA, 'Multi-site phosphorylation of CaMKII regulates CaMKII function co-operatively', JOURNAL OF NEUROCHEMISTRY, 123 116-116 (2012) [E3]
Author URL
Co-authorsJohn Rostas, Kathryn Skelding
2012Skelding KA, Spratt NJ, Fluechter L, Dickson PW, Rostas JA, 'alpha CaMKII is differentially regulated in brain regions that exhibit differing sensitivities to ischemia and excitotoxicity', Journal of Cerebral Blood Flow and Metabolism, 32 2181-2192 (2012) [C1]
CitationsScopus - 5Web of Science - 6
Co-authorsNeil Spratt, Kathryn Skelding, John Rostas
2012Ong LK, Sominsky L, Dickson PW, Hodgson DM, Dunkley PR, 'The sustained phase of Tyrosine hydroxylase activation in vivo', Neurochemical Research, 37 1938-1943 (2012) [C1]
CitationsScopus - 6Web of Science - 5
Co-authorsPeter Dunkley, Linkooi Ong, Deborah Hodgson
2012Damanhuri HA, Burke PGR, Ong LK, Bobrovskaya L, Dickson PW, Dunkley PR, Goodchild AK, 'Tyrosine hydroxylase phosphorylation in catecholaminergic brain regions: A marker of activation following acute hypotension and glucoprivation', Plos One, 7 1-19 (2012) [C1]
CitationsScopus - 10Web of Science - 7
Co-authorsLinkooi Ong, Peter Dunkley
2011Briggs GD, Gordon SL, Dickson PW, 'Mutational analysis of catecholamine binding in tyrosine hydroxylase', Biochemistry, 50 1545-1555 (2011) [C1]
DOI10.1021/bi101455b
CitationsScopus - 7Web of Science - 6
2011Aumann TD, Egan K, Lim J, Boon WC, Bye CR, Chua HK, et al., 'Neuronal activity regulates expression of tyrosine hydroxylase in adult mouse substantia nigra pars compacta neurons', Journal of Neurochemistry, 116 646-658 (2011) [C1]
DOI10.1111/j.1471-4159.2010.07151.x
CitationsScopus - 12Web of Science - 10
2011Ong LK, Guan L, Stutz B, Dickson PW, Dunkley PR, Bobrovskaya L, 'The effects of footshock and immobilization stress on tyrosine hydroxylase phosphorylation in the rat locus coeruleus and adrenal gland', Neuroscience, 192 20-27 (2011) [C1]
DOI10.1016/j.neuroscience.2011.06.087
CitationsScopus - 7Web of Science - 7
Co-authorsPeter Dunkley, Linkooi Ong
2011Ong LK, Bobrovskaya L, Walker FR, Day TA, Dickson PW, Dunkley PR, 'The effect of social defeat on tyrosine hydroxylase phosphorylation in the rat brain and adrenal gland', Neurochemical Research, 36 27-33 (2011) [C1]
DOI10.1007/s11064-010-0255-7
CitationsScopus - 7Web of Science - 7
Co-authorsRohan Walker, Peter Dunkley, Linkooi Ong, Trevor Day
2010Bobrovskaya L, Damanhuri HA, Ong LK, Schneider JJ, Dickson PW, Dunkley PR, Goodchild AK, 'Signal transduction pathways and tyrosine hydroxylase regulation in the adrenal medulla following glucoprivation: An in vivo analysis', Neurochemistry International, 57 162-167 (2010) [C1]
DOI10.1016/j.neuint.2010.05.009
CitationsScopus - 11Web of Science - 11
Co-authorsJennifer Schneider, Peter Dunkley, Linkooi Ong
2010Double KL, Halliday GM, Dunkley PR, Dickson PW, Gerlach M, Riederer P, 'Pigmentation in the human brain and risk of Parkinson's Disease', Annals of Neurology, 67 553-554 (2010) [C3]
CitationsScopus - 2Web of Science - 1
Co-authorsPeter Dunkley
2010Posser T, Dunkley PR, Dickson PW, Franco JL, 'Human neuroblastoma cells transfected with tyrosine hydroxylase gain increased resistance to methylmercury-induced cell death', Toxicology in Vitro, 24 1498-1503 (2010) [C1]
DOI10.1016/j.tiv.2010.07.015
CitationsScopus - 8Web of Science - 9
Co-authorsPeter Dunkley
2010Skelding KA, Suzuki T, Gordon SL, Xue J, Verrills NM, Dickson PW, Rostas JA, 'Regulation of CaMKII by phospho-Thr253 or phospho-Thr286 sensitive targeting alters cellular function', Cellular Signalling, 22 759-769 (2010) [C1]
DOI10.1016/j.cellsig.2009.12.011
CitationsScopus - 9Web of Science - 9
Co-authorsJohn Rostas, Kathryn Skelding, Nikki Verrills
2010Franco JL, Posser T, Gordon SL, Bobrovskaya L, Schneider JJ, Farina M, et al., 'Expression of tyrosine hydroxylase increases the resistance of human neuroblastoma cells to oxidative insults', Toxicological Sciences, 113 150-157 (2010) [C1]
DOI10.1093/toxsci/kfp245
CitationsScopus - 10Web of Science - 8
Co-authorsJennifer Schneider, Peter Dunkley
2009Posser T, Franco JL, Bobrovskaya L, Leal RB, Dickson PW, Dunkley PR, 'Manganese induces sustained Ser40 phosphorylation and activation of tyrosine hydroxylase in PC12 cells', Journal of Neurochemistry, 110 848-856 (2009) [C1]
DOI10.1111/j.1471-4159.2009.06185.x
CitationsScopus - 16Web of Science - 13
Co-authorsPeter Dunkley
2009Gordon SL, Bobrovskaya L, Dunkley PR, Dickson PW, 'Differential regulation of human tyrosine hydroxylase isoforms 1 and 2 in situ: Isoform 2 is not phosphorylated at Ser35', Biochimica et Biophysica Acta - Molecular Cell Research, 1793 1860-1867 (2009) [C1]
DOI10.1016/j.bbamcr.2009.10.001
CitationsScopus - 21Web of Science - 21
Co-authorsPeter Dunkley
2009Gordon SL, Webb JK, Shehadeh J, Dunkley PR, Dickson PW, 'The low affinity dopamine binding site on tyrosine hydroxylase: The role of the N-Terminus and in situ regulation of enzyme activity', Neurochemical Research, 34 1830-1837 (2009) [C1]
DOI10.1007/s11064-009-9989-5
CitationsScopus - 7Web of Science - 6
Co-authorsPeter Dunkley
2009Franco JL, Posser T, Dunkley PR, Dickson PW, Mattos JJ, Martins R, et al., 'Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase', Free Radical Biology and Medicine, 47 449-457 (2009) [C1]
DOI10.1016/j.freeradbiomed.2009.05.013
CitationsScopus - 70Web of Science - 66
Co-authorsPeter Dunkley
2008Gordon SL, Quinsey NS, Dunkley PR, Dickson PW, 'Tyrosine hydroxylase activity is regulated by two distinct dopamine-binding sites', Journal of Neurochemistry, 106 1614-1623 (2008) [C1]
DOI10.1111/j.1471-4159.2008.05509.x
CitationsScopus - 19Web of Science - 18
Co-authorsPeter Dunkley
2007Bobrovskaya L, Gelain DP, Gilligan C, Dickson PW, Dunkley PR, 'PACAP stimulates the sustained phosphorylation of tyrosine hydroxylase at serine 40', Cellular Signalling, 19 1141-1149 (2007) [C1]
DOI10.1016/j.cellsig.2006.12.006
CitationsWeb of Science - 33
Co-authorsConor Gilligan, Peter Dunkley
2007Bobrovskaya L, Gilligan C, Bolster EK, Flaherty JJ, Dickson PW, Dunkley PR, 'Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis', Journal of Neurochemistry, 100 479-489 (2007) [C1]
DOI10.1111/j.1471-4159.2006.04213.x
CitationsScopus - 48Web of Science - 48
Co-authorsPeter Dunkley, Conor Gilligan
2007Gelain DP, Moreira JCF, Bevilaqua LRM, Dickson PW, Dunkley PR, 'Retinol activates tyrosine hydroxylase acutely by increasing the phosphorylation of serine40 and then serine31 in bovine adrenal chromaffin cells', Journal of Neurochemistry, 103 2369-2379 (2007) [C1]
DOI10.1111/j.1471-4159.2007.04935.x
CitationsScopus - 14Web of Science - 14
Co-authorsPeter Dunkley
2006Migues PV, Lehmann IT, Fluechter L, Cammarota MP, Gurd JW, Sim AT, et al., 'Phosphorylation of CaMKII at Thr253 occurs in vivo and enhances binding to isolated postsynaptic densities', Journal of Neurochemistry, 98 289-299 (2006) [C1]
DOI10.1111/j.1471-4159.2006.03876.x
CitationsScopus - 24Web of Science - 22
Co-authorsAlistair Sim, John Rostas
2006Lehmann IT, Bobrovskaya L, Gordon SL, Dunkley PR, Dickson PW, 'Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation', Journal of Biological Chemistry, 281 17644-17651 (2006) [C1]
DOI10.1074/jbc.M512194200
CitationsScopus - 44Web of Science - 45
Co-authorsPeter Dunkley
2005Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Characterisation of tryptic peptides of phosphorylated tyrosine hydroxylase by high-pressure liquid chromatography electrospray ionisation mass spectrometry', Journal of Electron Spectroscopy and Related Phenomena, 142 271-276 (2005) [C1]
DOI10.1016/j.elspec.2004.09.008
CitationsScopus - 2Web of Science - 2
Co-authorsEllak, Peter Dunkley
2004Dunkley PR, Bobrovskaya L, Graham ME, Von Nagy-Felsobuki EI, Dickson PW, 'Tyrosine hydroxylase phosphorylation: regulation and consequences', Journal of Neurochemistry, 91 1025-1043 (2004) [C1]
DOI10.1111/j.1471-4159.2004.02797.x
CitationsScopus - 224Web of Science - 226
Co-authorsEllak, Peter Dunkley
2003Bevilaqua L, Cammarota MP, Dickson PW, Sim AT, Dunkley PR, 'Role of protein phosphatase 2C from bovine adrenal chromaffin cells in the dephosphorylation of phospho-serine 40 tyrosine hydroxylase', Journal of Neurochemistry, 85 1368-1373 (2003) [C1]
DOI10.1046/j.1471-4159.2003.01792.x
CitationsScopus - 18Web of Science - 18
Co-authorsAlistair Sim, Peter Dunkley
2001Bevilaqua L, Graham ME, Dunkley PR, Von Nagy-Felsobuki EI, Dickson PW, 'Phosphorylation of Ser19 Alters the Conformation of Tyrosine Hydroxylase to Increase the Rate of Phosphorylation of Ser40*', The Journal of Biological Chemistry, 276 No. 44 40411-40416 (2001) [C1]
CitationsScopus - 62Web of Science - 63
Co-authorsPeter Dunkley
2001Bevilaqua L, Graham ME, Von Nagy-Felsobuki EI, Dunkley PR, Dickson PW, 'Effect of phosphorylation on tyrosine hydroxylase shape', Journal of Neurochemistry, 78 Supt. 1 143 (2001) [C3]
Co-authorsPeter Dunkley
2001Graham ME, Bevilaqua L, Dunkley PR, Von Nagy-Felsobuki EI, Dickson PW, 'The Kinetics of CAMKII Phosphorylation of Dopamine Bound-Tyrosine Hydroxylase Determined by Electrospray Mass Spectrometry', ComBio 2001, 0 (2001) [C3]
Co-authorsPeter Dunkley
2000Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Determination of Phosphorylation Levels of Tyrosine Hydroxylase by Electrospray Mass Spectrometry', Analytical Biochemistry, 280 1-7 (2000) [C1]
CitationsWeb of Science - 8
Co-authorsPeter Dunkley, Ellak
1999Dickson PW, Wong Z, Harrap S, Abramson M, Walters E, 'Mutational analysis of the high affinity immunoglobulin E receptor Beta subunit gene in asthma', Thorax (The Journal of the British Thoracic Society), 54 409-412 (1999) [C1]
CitationsScopus - 19Web of Science - 17
1998Quinsey NS, Luong AQ, Dickson PW, 'Mutational analysis of substrate inhibition in tyrosine hydroxylase', Journal of Neurochemistry, 71 2132-2138 (1998) [C1]
CitationsScopus - 12Web of Science - 12
1998Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Characterisation of the phosphorylation of rat tyrosine hydroxylase using electrospray mass spectrometry', Rapid Communications in Mass Spectrometry, 12 746-748 (1998) [C1]
Co-authorsPeter Dunkley
1998Graham ME, Dickson P, Dunkley P, Von Nagy-Felsobuki EI, 'Characterization of the Phosphorylation of Rat Tyrosine Hydroxylase using Electrospray Mass Spectrometry', Rapid Communications in Mass Spectrometry, 12 746-748 (1998) [C1]
CitationsWeb of Science - 6
Co-authorsEllak, Peter Dunkley
Show 42 more journal articles

Conference (49 outputs)

YearCitationAltmetricsLink
2014Ong LK, Briggs GD, Dunkley PR, Dickson PW, 'The role of inflammation and dopamine synthesis in Parkinson's disease', JOURNAL OF NEUROCHEMISTRY, Kaohsiung, TAIWAN (2014) [E3]
Author URL
Co-authorsPeter Dunkley, Linkooi Ong
2013Skelding KA, Majeed ABA, Carpenter H, Dickson PW, Rostas JA, 'Can functional outcomes of CaMKII double phosphorylation be predicted from outcomes following single phosphorylation of CaMKII?', JOURNAL OF NEUROCHEMISTRY, Cancun, MEXICO (2013) [E3]
Author URL
Co-authorsJohn Rostas, Kathryn Skelding
2013Guan L, Werno M, Gordon SL, Dunkley P, Dickson PW, 'The effect of tyrosine hydroxylase on alpha-synuclein aggregation', JOURNAL OF NEUROCHEMISTRY, Cancun, MEXICO (2013) [E3]
Author URL
Co-authorsPeter Dunkley
2012Skelding KA, Abdul Majeed ABB, Dickson PW, Spratt NJ, Rostas JA, 'CAMKII is regulated differently in brains regions with differing sensitivities to ischaemia/excitotoxicity', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authorsKathryn Skelding, John Rostas, Neil Spratt
2012Briggs GD, Smith T, Hickey S, Dickson PW, 'A channel extending from the catalytic cleft of tyrosine hydroxylase is involved in high affinity catecholamine inhibition', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
2012Skelding KA, Dickson PW, Verrills NM, Rostas JA, 'Dephosphorylation of CAMKII at T253 controls progression through metaphase', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authorsKathryn Skelding, John Rostas, Nikki Verrills
2012Abdul Majeed ABB, Skelding KA, Dickson PW, Rostas JA, 'Does phosphorylation of CaMKII at multiple sites regulate CaMKII targeting co-operatively or independently?', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authorsJohn Rostas, Kathryn Skelding
2012Guan L, Werno M, Gordon SL, Dunkley PR, Dickson PW, 'Effect of tyrosine hydroxylase on alphasynuclein aggregation', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authorsPeter Dunkley
2012James MH, Charnley JL, Levi EM, Dunkley PR, Smith DW, Dickson PW, Dayas CV, 'A role for the mTOR pathway in the development of addiction', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authorsDouglas Smith, Christopher Dayas, Peter Dunkley
2012Rostas JA, Skelding KA, Fluechter L, Dickson PW, Spratt NJ, 'CaMKII is Differentially Regulated in Striatum and Cortex', JOURNAL OF NEUROCHEMISTRY (2012) [E3]
Author URL
Co-authorsJohn Rostas, Kathryn Skelding, Neil Spratt
2012Ong LK, Guan L, Bobrovskaya L, Dickson PW, Dunkley PR, 'Neurobiological consequences of acute footshock stress', Journal of Neurochemistry, Kobe, Japan (2012) [E3]
Co-authorsPeter Dunkley, Linkooi Ong
2012Rostas JA, Skelding KA, Fluechter L, Dickson PW, Spratt NJ, 'CaMKII is differentially regulated in striatum and cortex', Journal of Molecular Neuroscience: Abstracts The 21st Annual Meeting of the Israel Society for Neuroscience & The First Binational Australian-Israeli Meeting in Neuroscience, Eilat, Israel (2012) [E3]
Co-authorsKathryn Skelding, Neil Spratt, John Rostas
2010Ong LK, Guan L, Stutz B, Dickson PW, Dunkley PR, Bobrovskaya L, 'Tyrosine hydroxylase phosphorylation in response to footshock and restraint stress', Journal of Neurochemistry, Phuket, Thailand (2010) [E3]
DOI10.1093/jac/dkq221
CitationsScopus - 1
Co-authorsPeter Dunkley, Linkooi Ong
2010Skelding KA, Verrills NM, Dickson PW, Rostas JA, 'Regulation of proliferation of neuroblastoma cells by CaMKII', Proceding of the Australian Neuroscience Society, Sydney, NSW (2010) [E3]
Co-authorsKathryn Skelding, Nikki Verrills, John Rostas
2010Skelding KA, Xue J, Suzuki T, Verrills NM, Dickson PW, Rostas JA, 'Mechanisms of phosphorylation-sensitive CaMKII targeting', Proceding of the Australian Neuroscience Society, Sydney, NSW (2010) [E3]
Co-authorsKathryn Skelding, Nikki Verrills, John Rostas
2009Bobrovskaya L, Damanhuri H, Ong LK, Dickson PW, Dunkley PR, Goodchild AK, 'The effect of glucoprivation on tyrosine hydroxylase phosphorylation in adrenals of Sprague-Dawley rats', Autonomic Neuroscience: Basic and Clinical, Sydney, NSW (2009) [E3]
DOI10.1016/j.autneu.2009.05.191
Co-authorsLinkooi Ong, Peter Dunkley
2009Bobrovskaya L, Ong LK, Walker RA, Day TA, Dickson PW, Dunkley PR, 'The effect of social stress on tyrosine hydroxylase phosphorylation', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authorsLinkooi Ong, Peter Dunkley, Trevor Day
2009Gordon SL, Dunkley PR, Dickson PW, 'The low affinity dopamine binding site regulates tyrosine hydroxylase activity in situ: Implications for the regulation of cytosolic catecholamine levels', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authorsPeter Dunkley
2009Briggs GD, Gordon SL, Dunkley PR, Dickson PW, 'Localisation of the low affinity catecholamine binding site in tyrosine hydroxylase', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authorsPeter Dunkley
2009Skelding KA, Liao X, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Functional consequences of CaMKII phosphorylation at THR253 in neurons', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authorsJohn Rostas, Nikki Verrills, Alistair Sim, Kathryn Skelding
2009Rostas JA, Skelding KA, Liao X, Verrills NM, Dickson PW, 'Regulation of CaMKII by targeting', Proceedings of the 2nd Australia-China Biomedical Research Conference, - (2009) [E3]
Co-authorsNikki Verrills, John Rostas, Kathryn Skelding
2009Gordon SL, Bobrovskaya L, Dunkley PR, Dickson PW, 'Differential regulation of the two major isoforms of human tyrosine hydroxylase in situ', Journal of Neurochemistry, Busan, Korea (2009) [E3]
DOI10.1111/j.1471-4159.2009.06242.x
Co-authorsPeter Dunkley
2009Skelding KA, Liao X, Verrills NM, Fluechter L, Dickson PW, Rostas JA, 'CaMKII phosphorylation at T253 alters neuronal growth rates and morphology', Journal of Neurochemistry, Busan, Korea (2009) [E3]
DOI10.1111/j.1471-4159.2009.06238.x
Co-authorsKathryn Skelding, Nikki Verrills, John Rostas
2009Ong LK, Bobrovskaya L, Walker FR, Day TA, Dickson PW, Dunkley PR, 'The effect of social conflict on tyrosine hydroxylase phosphorylation in catecholamine-producing cells from sprague-dawley rats', Journal of Neurochemistry, Busan, Korea (2009) [E3]
DOI10.1111/j.1471-4159.2009.06242.x
Co-authorsTrevor Day, Peter Dunkley, Linkooi Ong, Rohan Walker
2009Dickson PW, Shehadeh J, Double KL, Bobrovskaya L, Reyes S, Dunkley PR, Halliday GM, 'Distribution of tyrosine hydroxylase isoforms in the human brain', Journal of Neurochemistry, Busan, Korea (2009) [E3]
DOI10.1111/j.1471-4159.2009.06239.x
Co-authorsPeter Dunkley
2009Shehadeh J, Double K, Murphy K, Bobrovskaya L, Reyes S, Dunkley PR, et al., 'Differential distribution of tyrosine hydroxylase isoforms in the human brain', Parkinsonism & Related Disorders, Miami Beach, FL (2009) [E3]
Co-authorsPeter Dunkley
2008Gelain DP, Mareira JC, Bevilaqua LRM, Dickson PW, Dunkley PR, 'Retinol stimulates tyrosine hydroxylase activity by increasing ser40 phosphorylation in bovine adrenal chromaffin cells', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authorsPeter Dunkley
2008Lonergan T, Bobrovskaya L, Dunkley PR, Dickson PW, Pilowsky PM, Goodchild A, 'Intracellular signaling pathways in catecholaminergic cells activitated by glucoprivation', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authorsPeter Dunkley
2008Posser T, Franco JL, Bobrovskaya L, Leal RB, Dickson PW, Dunkley PR, 'Sustained tyrosine hydroxylase phosphorylation in pc12 cells exposed to manganese', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authorsPeter Dunkley
2008Skelding KA, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Identification of CaMKII binding proteins in brain sensitive to CaMKII phosphorylation state', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authorsAlistair Sim, Nikki Verrills, Kathryn Skelding, John Rostas
2008Gelain DP, Moreira JC, Bevilaqua LRM, Dickson PW, Dunkley PR, 'Retinol stimulates tyrosine hydroxylase activity by increasing ser40 and then ser 31 phosphorylation in bovine adrenal chromaffin cells', Journal of Neurochemistry, Shanghai, China (2008) [E3]
Co-authorsPeter Dunkley
2008Skelding KA, Verrills NM, Fluechter L, Sim AT, Dickson PW, Rostas JA, 'Development of a novel method for the identification of CaMKII binding proteins', Journal of Neurochemistry, Shanghai, China (2008) [E3]
Co-authorsAlistair Sim, John Rostas, Kathryn Skelding, Nikki Verrills
2007Bobrovskaya L, Gelain D, Gilligan C, Flaherty J, Bolster EK, Dickson PW, Dunkley PR, 'Nicotine and Pacap stimulate the sustained phosphorylation of tyrosine hydroxylase at serine 40 (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
Co-authorsConor Gilligan, Peter Dunkley
2007Gordon SL, Quinsey NS, Dunkley PR, Dickson PW, 'Tyrosine hydroxylase activity is regulated by two distinct dopamine binding sites (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
Co-authorsPeter Dunkley
2007Gelain DP, Moreira JC, Bevilaqua LR, Dickson PW, Dunkley PR, 'Retinol stimulates tyrosine hydroxylase activity by increasing Ser40 phosphorylation in bovine adrenal chromaffin cells', JOURNAL OF NEUROCHEMISTRY, Cancun, MEXICO (2007)
Author URL
Co-authorsPeter Dunkley
2006Rostas JAP, Migues P, Lehmann IT, Fluechter L, Cammarota M, Gurd JW, et al., 'Phosphorylation of CAMKII at Thr253 occurs in vivo and enhances binding to isolated post synaptic densities', JOURNAL OF NEUROCHEMISTRY, Singapore, SINGAPORE (2006)
Author URL
Co-authorsJohn Rostas
2006Dunkley PR, Bobrovskaya L, Gilligan C, Bolster EK, Flaherty J, Dickson PW, 'Sustained phosphorylation of tyrosine hydroxylase at serine 40 is inhibited by the antidepressant imipramine', Proceedings of the Australian Neuroscience Society, Sydney, NSW (2006) [E3]
Co-authorsPeter Dunkley, Conor Gilligan
2006Lehmann IT, Bobrovskaya L, Dunkley PR, Dickson PW, 'Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3]
Co-authorsPeter Dunkley
2006Rostas JA, Migues PV, Fluechter L, Dickson PW, Sim AT, Rawoff S, et al., 'Phosphorylation of CAMKII at T253 induced by transient global ischaemia', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3]
Co-authorsAlistair Sim, John Rostas
2005Dunkley PR, Bobrovskaya L, Gilligan C, Soster E, Dickson PW, 'Sustained phosphorylation of tyrosine hydroxylase at Ser40', JOURNAL OF NEUROCHEMISTRY, Innsbruck, AUSTRIA (2005) [E1]
Author URL
Co-authorsPeter Dunkley, Conor Gilligan
2005Lehmann IT, Bobrovskaya L, Dunkley PR, Dickson PW, 'Phosphorylation of Ser31 increases the activation of tyrosine hydroxylase via hierarchical phosphorylation', JOURNAL OF NEUROCHEMISTRY, Innsbruck, AUSTRIA (2005) [E1]
Author URL
Co-authorsPeter Dunkley
2005Migues PV, Lehmann IT, Fluechter L, Cammarota M, Sim AT, Gurd JW, et al., 'Phosphorylation of CaMKII on T253 enhances its association with postsynaptic densities', JOURNAL OF NEUROCHEMISTRY, Innsbruck, AUSTRIA (2005)
Author URL
Co-authorsJohn Rostas
2004Bobrovskaya L, Dunkley PR, Dickson PW, 'Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells', Journal of Neurochemistry, England (2004) [E1]
DOI10.1111/j.1471-4159.2004.02550.x
CitationsScopus - 40Web of Science - 41
Co-authorsPeter Dunkley
2004Bobrovskaya L, Bolster EK, Dickson PW, Dunkley PR, 'Angiotensin II-Stimulated phosphorylation of tyrosine hydroxylase in bovine adrenal chromaffin cells: The role of PKC isozymes', Proceedings of the Australian Neuroscience Society, Melbourne, Australia (2004) [E3]
Co-authorsPeter Dunkley
2004Dunkley PR, Bobrovskaya L, Dickson PW, Rose J, Lehmann IT, 'Hierarchical phosphorylation of tyrosine hydroxylase in bovine adrenal chromaffin cells', Journal of Neurochemistry, Hong Kong (2004) [E3]
Co-authorsPeter Dunkley
2003Bobrovskaya L, Dickson PW, Dunkley PR, 'Hierarchical Phosphorylation of SER19 and SER40 on Tyrosine Hydroxylase in Bovine Adrenal Chromaffin Cells', Proccedings of the Australian Neuroscience Society, Adelaide, Australia (2003) [E3]
Co-authorsPeter Dunkley
2003Bobrovskaya L, Dunkley PR, Dickson PW, 'Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells', JOURNAL OF NEUROCHEMISTRY, WANCHAI, PEOPLES R CHINA (2003) [E1]
Author URL
Co-authorsPeter Dunkley
2001Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Quantification of phosphorylation levels of tyrosine hydroxylase utilkizing protein cleavage and electrospray mass spectrometry', Advances in Mass Spectrometry, Barcelona, Spain (2001) [E3]
Co-authorsEllak, Peter Dunkley
2001Bevilaqua LRM, Graham ME, Von Nagy-Felsobuki EI, Dunkley RR, Dickson PW, 'Effect of phosphorylation on tyrosine hydroxylase shape', JOURNAL OF NEUROCHEMISTRY (2001) [E1]
Author URL
Co-authorsEllak
Show 46 more conferences
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Grants and Funding

Summary

Number of grants39
Total funding$4,354,918

Click on a grant title below to expand the full details for that specific grant.


20143 grants / $463,826

Role of infection in the development of Parkinson's Disease $185,679

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1301295
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Expanding the Genomic Frontier - from Species to Strains and Individuals to Populations$150,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Marc Wilkins, Professor Rick Cavicchioli, Professor Brett Neilan, Professor Rodney Scott, Laureate Professor Paul Foster, Associate Professor Phillip Dickson, Professor Ian Charles, Associate Professor Elizabeth Harry, Associate Professor Steven Djordjevic, Associate Professor Cynthia Whitchurch, Professor Ian Paulsen, Professor Nicolle Packer, Professor Michael Gillings
SchemeEquipment Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1300426
Type Of FundingInternal
CategoryINTE
UONY

Expanding the Genomic Frontier - from Species to Strains and Individuals to Populations$128,147

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Marc Wilkins, Professor Rick Cavicchioli, Professor Brett Neilan, Professor Rodney Scott, Laureate Professor Paul Foster, Associate Professor Phillip Dickson, Professor Ian Paulsen, Professor Nicolle Packer, Professor Michael Gillings, Professor Ian Charles, Associate Professor Elizabeth Harry, Associate Professor Steven Djordjevic, Associate Professor Cynthia Whitchurch
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301339
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

20133 grants / $61,596

42nd Annual Meeting of the Brazilian Society of Biochemistry and Molecular Biology, Brazil 18-21 May 13.$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamAssociate Professor Phillip Dickson
SchemeTravel Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300791
Type Of FundingInternal
CategoryINTE
UONY

20124 grants / $396,463

Human tyrosine hydroxylase isoforms and susceptibility of dopaminergic neurons to degeneration in Parkinson's disease$354,601

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Associate Professor Kay Double
SchemeProject Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1100113
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Role of CaMKII targeting in neuronal susceptibility to excitotoxic cell death$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor John Rostas, Doctor Neil Spratt, Associate Professor Phillip Dickson, Doctor Nikki Verrills
SchemeNear Miss Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200673
Type Of FundingInternal
CategoryINTE
UONY

Regulation of the cell cycle by phosphorylation dependent targeting of CaMKII$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Nikki Verrills, Doctor Kathryn Skelding, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Conjoint Professor Keith Jones
SchemeNear Miss Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200679
Type Of FundingInternal
CategoryINTE
UONY

10th International catecholamine symposium, pacific Grove, California, 9 - 13 September 2012$1,862

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamAssociate Professor Phillip Dickson
SchemeTravel Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200814
Type Of FundingInternal
CategoryINTE
UONY

20111 grants / $10,000

IMPLEN NanoPhotometer pearl$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Professor Alan Brichta, Emeritus Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Professor Ulli Schall, Associate Professor Phillip Dickson, Doctor Frederick Walker, Doctor Rick Thorne, Doctor Chris Dayas, Doctor Nikki Verrills, Doctor Janet Holt, Doctor Severine Roselli, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Associate Professor Liz Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Mr Dan Johnstone, Ms Belinda Goldie, Doctor Natalie Beveridge
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100030
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20102 grants / $94,000

Repair of the nigrostriatal pathway by phenotype shift of dopamine neurones$60,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Phillip Dickson, Professor Malcolm Horne
SchemeProject Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG1000068
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

ABI 7500 Real Time PCR System $34,000

Funding body: NHMRC (National Health & Medical Research Council)

20092 grants / $545,000

20072 grants / $839,250

Functional Characterisation of a New Regulatory Mechanism for CaMKII at Synapses in Vivo$526,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Alistair Sim
SchemeProject Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0186415
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Differential regulation of human tyrosine hydroxylase isoforms and the development of Parkinson's disease$312,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Associate Professor Kay Double
SchemeProject Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0186394
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20064 grants / $652,138

Functional Characterisation of CaMKII Phosphorylate at a New Site in vivo$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Alistair Sim
SchemeNear Miss Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0186059
Type Of FundingInternal
CategoryINTE
UONY

Differential regulation of human tyrosine hydroxyase isoforms and susceptibility of dopaminergic neurons to degeneration$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Associate Professor Kay Double
SchemeNear Miss Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186079
Type Of FundingInternal
CategoryINTE
UONY

BioRad Mini-PROTEAN3 Electrophoresis system$995

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamEmeritus Professor Leonie Ashman, Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Professor Judith Scott, Professor Alistair Sim, Doctor Nikki Verrills
SchemeEquipment Grant
RoleInvestigator
Funding Start2006
Funding Finish2006
GNoG0187280
Type Of FundingNot Known
CategoryUNKN
UONY

20055 grants / $578,349

A novel mechanism for the maintenance of catecholamine synthesis$351,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
SchemeProject Grant
RoleInvestigator
Funding Start2005
Funding Finish2005
GNoG0184211
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Control of Dopamine synthesis and Parkinsons' disease$10,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeProject Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185977
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Regulation of Human Tyrosine Hydroxylase Isoforms by Hierarchical Phosphorylation$8,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeProject Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0184779
Type Of FundingInternal
CategoryINTE
UONY

ISN 20th Biennial Meeting of the International Society for Neurochemistry, 21-26 August 2005$2,160

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Phillip Dickson
SchemeTravel Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185672
Type Of FundingInternal
CategoryINTE
UONY

20042 grants / $191,481

Biacore3000-Expansion of Proteomics Facility$187,341

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamProfessor Alistair Sim, Laureate Professor John Aitken, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Emeritus Professor Leonie Ashman, Professor Roger Smith, Professor Gordon Burns, Professor Adam McCluskey, Associate Professor Paul Tooney, Dr Fraser Ross, Conjoint Professor Ray Rose
SchemeLinkage Infrastructure Equipment & Facilities (LIEF)
RoleInvestigator
Funding Start2004
Funding Finish2004
GNoG0183030
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Wide Gel Format Western Blot Apparatus for the Medical Biochemistry Group$4,140

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Phillip Dickson
SchemeProject Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0184540
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20032 grants / $146,000

Hierarchical Phosphorylation of Tyrosine Hydroxylase is Dependent on the Activation Sequence of Signaling Pathways.$135,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamAssociate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeDiscovery Projects
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182096
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Dephosphorylation of tyrosine hydroxylase$11,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Phillip Dickson
SchemeProject Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182434
Type Of FundingInternal
CategoryINTE
UONY

20024 grants / $314,315

Control of catecholamine synthesis and secretion by angiotensin II$270,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
SchemeProject Grant
RoleInvestigator
Funding Start2002
Funding Finish2002
GNoG0180883
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Peltier Thermal Cycler and associated equipment essential for establishing cDNA Retroviral Libraries$21,315

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamEmeritus Professor Leonie Ashman, Dr Petranel Ferrao, Professor Gordon Burns, Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Dirk Van Helden, Dr Perry Hartfield
SchemeEquipment Grant
RoleInvestigator
Funding Start2002
Funding Finish2002
GNoG0181919
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Elucidation of the mechanism of tyrosine hydroxylase regulation by the use on mass spectrometry$12,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Phillip Dickson
SchemeProject Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181403
Type Of FundingInternal
CategoryINTE
UONY

Dephosphorylation of tyrosine hydroxylase in vitro and in vivo$11,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Phillip Dickson, Dr Martin Cammarota
SchemeProject Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181404
Type Of FundingInternal
CategoryINTE
UONY

20011 grants / $13,000

Control of Catecholamine Synthesis by Tyrosine Hydroxylase.$13,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamEmeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Emeritus Professor Ellak Von Nagy-Felsobuki, Professor Alistair Sim
SchemeProject Grant
RoleInvestigator
Funding Start2001
Funding Finish2001
GNoG0180125
Type Of FundingInternal
CategoryINTE
UONY

20002 grants / $24,500

Control of Catecholamine Synthesis by Tyrosine Hydroxylase.$14,500

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamEmeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Emeritus Professor Ellak Von Nagy-Felsobuki
SchemeSmall Grant
RoleInvestigator
Funding Start2000
Funding Finish2000
GNoG0178980
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

Loss of control of dopamine synthesis and induction of neurodegeneration in Parkinson' Disease.$10,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamAssociate Professor Phillip Dickson, Conjoint Professor David Powis
SchemeSmall Grant
RoleLead
Funding Start2000
Funding Finish2000
GNoG0178912
Type Of FundingScheme excluded from IGS
CategoryEXCL
UONY

19992 grants / $25,000

FPLC Protein Purification System$16,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Alistair Sim, Emeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
SchemeEquipment Grant
RoleInvestigator
Funding Start1999
Funding Finish1999
GNoG0180790
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Development of a cellular model to study regulation of neurotransmitter synthesis$9,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
SchemeProject Grant
RoleLead
Funding Start1999
Funding Finish1999
GNoG0178050
Type Of FundingInternal
CategoryINTE
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Role of Inflammation in Parkinson's Disease
Medical Science, Faculty of Health and Medicine
Principal Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2015Regulation of Tyrosine Hydroxylase in Stress and Parkinson's Disease
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2013Investigation of Catecholamine Inhibition in Tyrosine Hydroxylase
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2013Effects of Multi-site Phosphorylation on CaMKII Function
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2012Neurobiological Consequences of Stress: Tyrosine Hydroxylase Phosphorylation in Response to Stress
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2010Differential Distribution of Tyrosine Hydroxylase Isoforms and Phosphorylation in Parkinson Disease
Medical Science, Faculty of Health and Medicine
Principal Supervisor
2009Acute Regulation of Tyrosine Hydroxylase
Medical Science, Faculty of Health and Medicine
Principal Supervisor
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Associate Professor Phillip Dickson

Position

Associate Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Medical Biochemistry

Contact Details

Emailphil.dickson@newcastle.edu.au
Phone(02) 4921 7031
Fax(02) 4921 6903

Office

RoomLS3-47
BuildingLife Sciences Building
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
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