Profile Image

Dr Chris Dayas

Senior Lecturer

School of Biomedical Sciences and Pharmacy (Anatomy)

Career Summary

Biography

I completed my PhD at the University of Queensland, Brisbane, Australia in 2000. The focus of this work was to identify parts of the brain that controlled neuroendocrine responses to different forms of stress. This work showed that different categories of stress - psychological or physiological (e.g. infection) - elicit distinct cellular activity "footprints" within the amygdala and sub-populations of catecholamine cells within the brainstem. This finding was because the consensus at the time was that these brain regions responded homogenously to stress irrespective of the 'category' or nature of the stimulus. At the end of my PhD I was awarded a CJ Martin fellowship from the NHMRC that allowed me to travel to the United States to undertake post-doctoral training at The Scripps Research Institute in California, San Diego.

My post-doctoral research at The Scripps Research Institute contributed to the understanding of the neural pathways that control reinstatement of alcohol relapse. In articles published in the journal Biological Psychiatry and Journal of Neuroscience, I showed that the pattern of neural activity elicited by stimuli conditioned to predict the availability of alcohol, a factor linked to increased relapse risk in humans, is similar to the patterns produced by stimuli paired with the availability of other commonly abused drugs such as cocaine or nicotine. Additionally, we demonstrated how existing neuropharmacological treatments for alcoholism such as naltrexone, or newer agents that show promise in the treatment of addiction such as agonists for group II/III metabotropic glutamate (mGlu2/3) receptors, also modulate these patterns. We also showed that mGlu2/3 receptor agonists, which appear to have an anxiolytic profile, are effective in suppressing reinstatement (or relapse) elicited by stress - an important trigger for relapse in humans.
At Scripps I also demonstrated that hypothalamic peptide systems, better known for their role in feeding behaviour, may be important neurotransmitters in the brain circuitry that trigger alcohol seeking behaviour.

After returning to Australia in 2006, I established my own laboratory in the Discipline of Anatomy, School of Biomedical Sciences and Pharmacy, University of Newcastle to investigate the role of these hypothalamic peptides in driving drug-seeking and relapse-like behaviour. I received an NHMRC grant in 2007 to commence this work. My laboratory therefore focuses on the brain pathways that are involved in addiction and stress.

Research Expertise
Relapse to drug taking is considered the most significant obstacle to the successful treatment of addiction. Although much progress has been made in identifying individual brain regions that elicit drug-seeking behaviour and subsequently relapse, there are presently very few effectively pharmaceutical or indeed behavioural therapy strategies available to treat this disease. My research interests concern the following key issues: 1.Understanding the neuroanatomical and pharmacological interactions between key components of brain circuitry thought to be responsible for provoking drug relapse. 2.Determining the role of the neuropeptides (orexin/hypocretin and CART) recently found to be powerful modulators of drug-seeking and relapse. 3.Elucidating the cellular and molecular neuroadaptations that promotes long-term relapse vulnerability. 4.Determining the neurobiological basis for why some individuals become addicted and show greater vulnerability to drug relapse than others. 

Collaborations
Relapse to drug taking is considered the most significant obstacle to the successful treatment of addiction. Although much progress has been made in identifying individual brain regions that elicit drug-seeking behaviour and subsequently relapse, there are presently very few effectively pharmaceutical or indeed behavioural therapy strategies available to treat this disease. My research interests concern the following key issues: 1. Understanding the neuroanatomical and pharmacological interactions between key components of brain circuitry thought to be responsible for provoking drug relapse. 2. Determining the role of the neuropeptides (orexin/hypocretin and CART) recently found to be powerful modulators of drug-seeking and relapse. 3. Elucidating the cellular and molecular neuroadaptations that promotes long-term relapse vulnerability. 4. Determining the neurobiological basis for why some individuals become addicted and show greater vulnerability to drug relapse than others.


Qualifications

  • PhD, University of Queensland
  • Bachelor of Science (Honours), University of Queensland

Keywords

  • Biochemistry
  • Cell Biology
  • Neurosciences

Fields of Research

CodeDescriptionPercentage
110999Neurosciences not elsewhere classified100

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
27/09/2014 - 28/09/2014Casual LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/2014 - Senior LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

DatesTitleOrganisation / Department
1/11/2006 - 1/12/2008CJ Martin Biomedical Fellowships (Overseas)
NHMRC - Early Career Fellowships (Formerly Postdoctoral Training Fellowships)
National Health & Medical Research Council

Membership

DatesTitleOrganisation / Department
Member - Society for NeuroscienceSociety for Neuroscience
Australia
Member - Australian Neuroscience SocietyAustralian Neuroscience Society (ANS)
Australia
Member - Research Society on AlcoholismResearch Society on Alcoholism
Australia

Invitations

Participant

YearTitle / Rationale
2004" Invited speaker at the Research Society on Alcoholism Meeting in Vancouver, Canada, 2004
Organisation: Research Society on Alcholism
Edit

Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Book (1 outputs)

YearCitationAltmetricsLink
2015Caillé S, Baker AL, Todd J, Turner A, Dayas CV, Smoking and mental health problems, S. Karger AG (2015)

Patients with mental illness have greater rates of smoking during their lifetime and experience severe social, health and psychological disadvantages, and stigma. This chapter begins by providing a brief update on the neurobiology of nicotine addiction and we present evidence that an imbalance in the brain reward and aversion systems, and specific nicotinic acetylcholine receptor subtypes expressed in these pathways, may lead to dependence. Then, in a special case review, we highlight recent advances regarding the knowledge on the association between nicotine dependence and schizophrenia. Further understanding these mechanistic links, including nicotine-induced improvements in cognitive deficits, might provide new insights into improving smoking cessation success in people diagnosed with schizophrenia. Additionally, we discuss data indicating that smoking cessation does not worsen mental health symptoms or increase other drug and alcohol use. Indeed, smoking cessation interventions should be available within mental health and substance use treatment settings. Treatments for nicotine addiction include psychological interventions and pharmacological agents such as nicotine replacement therapies (e.g. gums and lozenges) or medications such as the partial agonist varenicline. Importantly, the outcomes for smokers with mental illness are enhanced when these approaches are combined and may need to be administered over the long term.

DOI10.1159/000369483
Co-authorsAmanda Baker, Juanita Todd

Journal article (36 outputs)

YearCitationAltmetricsLink
2015Quinn RK, Brown AL, Goldie BJ, Levi EM, Dickson PW, Smith DW, et al., 'Distinct miRNA expression in dorsal striatal subregions is associated with risk for addiction in rats.', Transl Psychiatry, 5 e503 (2015)
DOI10.1038/tp.2014.144Author URL
Co-authorsPhil Dickson, Murray Cairns
2015Campbell EJ, Watters SM, Zouikr I, Hodgson DM, Dayas CV, 'Recruitment of hypothalamic orexin neurons after formalin injections in adult male rats exposed to a neonatal immune challenge', Frontiers in Neuroscience, 9 (2015)

Exposure to early life physiological stressors, such as infection, is thought to contribute to the onset of psychopathology in adulthood. In animal models, injections of the bacterial immune challenge, lipopolysaccharide (LPS), during the neonatal period has been shown to alter both neuroendocrine function and behavioral pain responses in adulthood. Interestingly, recent evidence suggests a role for the lateral hypothalamic peptide orexin in stress and nociceptive processing. However, whether neonatal LPS exposure affects the reactivity of the orexin system to formalin-induced inflammatory pain in later life remains to be determined. Male Wistar rats (n =3D 13) were exposed to either LPS or saline (0.05 mg/kg, i.p) on postnatal days (PND) 3 and 5. On PND 80-97, all rats were exposed to a subcutaneous hindpaw injection of 2.25% formalin. Following behavioral testing, animals were perfused and brains processed for Fos-protein and orexin immunohistochemistry. Rats treated with LPS during the neonatal period exhibited decreased licking behaviors during the interphase of the formalin test, the period typically associated with the active inhibition of pain, and increased grooming responses to formalin in adulthood. Interestingly, these behavioral changes were accompanied by an increase in the percentage of Fos-positive orexin cells in the dorsomedial and perifornical hypothalamus in LPS-exposed animals. Similar increases in Fos-protein were also observed in stress and pain sensitive brain regions that receive orexinergic inputs. These findings highlight a potential role for orexin in the behavioral responses to pain and provide further evidence that early life stress can prime the circuitry responsible for these responses in adulthood.

DOI10.3389/fnins.2015.00065
CitationsScopus - 1
Co-authorsDeborah Hodgson
2015Parkinson GM, Dayas CV, Smith DW, 'Age-related gene expression changes in substantia nigra dopamine neurons of the rat.', Mech Ageing Dev, 149 41-49 (2015)
DOI10.1016/j.mad.2015.06.002Author URL
2014James MH, Quinn RK, Ong LK, Levi EM, Charnley JL, Smith DW, et al., 'mTORC1 inhibition in the nucleus accumbens 'protects' against the expression of drug seeking and 'relapse' and is associated with reductions in GluA1 AMPAR and CAMKIIa levels.', Neuropsychopharmacology, 39 1694-1702 (2014) [C1]
DOI10.1038/npp.2014.16Author URL
CitationsScopus - 1
Co-authorsLinkooi Ong, Phil Dickson, Douglas Smith
2014Goldie BJ, Dun MD, Lin M, Smith ND, Verrills NM, Dayas CV, Cairns MJ, 'Activity-associated miRNA are packaged in Map1b-enriched exosomes released from depolarized neurons.', Nucleic Acids Research, 42 9195-9208 (2014) [C1]
DOI10.1093/nar/gku594Author URL
CitationsScopus - 4Web of Science - 3
Co-authorsMurray Cairns, Matt Dun, Minjie Lin, Nikki Verrills
2014Zouikr I, James MH, Campbell EJ, Clifton VL, Beagley KW, Dayas CV, Hodgson DM, 'Altered formalin-induced pain and Fos induction in the periaqueductal grey of preadolescent rats following neonatal LPS exposure.', PLoS One, 9 e98382 (2014) [C1]
DOI10.1371/journal.pone.0098382Author URL
CitationsScopus - 1Web of Science - 1
Co-authorsDeborah Hodgson, Vicki Clifton
2014Parkinson GM, Dayas CV, Smith DW, 'Increased mitochondrial DNA deletions in substantia nigra dopamine neurons of the aged rat.', Curr Aging Sci, 7 155-160 (2014)
Author URL
2014Parkinson GM, Dayas CV, Smith DW, 'Increased mitochondrial DNA deletions in substantia nigra dopamine neurons of the aged rat.', Current aging science, 7 155-160 (2014) [C2]
Co-authorsDouglas Smith
2014Zouikr I, James MH, Campbell EJ, Clifton VL, Beagley KW, Dayas CV, Hodgson DM, 'Altered formalin-induced pain and fos induction in the periaqueductal grey of preadolescent rats following neonatal LPS exposure', PLoS ONE, 9 (2014) [C1]

Animal and human studies have demonstrated that early pain experiences can produce alterations in the nociceptive systems later in life including increased sensitivity to mechanical, thermal, and chemical stimuli. However, less is known about the impact of neonatal immune challenge on future responses to noxious stimuli and the reactivity of neural substrates involved in analgesia. Here we demonstrate that rats exposed to Lipopolysaccharide (LPS; 0.05 mg/kg IP, Salmonella enteritidis) during postnatal day (PND) 3 and 5 displayed enhanced formalin-induced flinching but not licking following formalin injection at PND 22. This LPS-induced hyperalgesia was accompanied by distinct recruitment of supraspinal regions involved in analgesia as indicated by significantly attenuated Fos-protein induction in the rostral dorsal periaqueductal grey (DPAG) as well as rostral and caudal axes of the ventrolateral PAG (VLPAG). Formalin injections were associated with increased Fos-protein labelling in lateral habenula (LHb) as compared to medial habenula (MHb), however the intensity of this labelling did not differ as a result of neonatal immune challenge. These data highlight the importance of neonatal immune priming in programming inflammatory pain sensitivity later in development and highlight the PAG as a possible mediator of this process. © 2014 Zouikr et al.

DOI10.1371/journal.pone.0098382
CitationsScopus - 2Web of Science - 1
Co-authorsDeborah Hodgson, Vicki Clifton
2014Yeoh JW, Campbell EJ, James MH, Graham BA, Dayas CV, 'Orexin antagonists for neuropsychiatric disease: progress and potential pitfalls.', Front Neurosci, 8 36 (2014) [C1]
DOI10.3389/fnins.2014.00036Author URL
CitationsScopus - 11Web of Science - 11
Co-authorsBrett Graham
2014Yeoh JW, James MH, Graham BA, Dayas CV, 'Electrophysiological characteristics of paraventricular thalamic (PVT) neurons in response to cocaine and cocaine- and amphetamine-regulated transcript (CART)', FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 8 (2014) [C1]
DOI10.3389/fnbeh.2014.00280Author URL
CitationsWeb of Science - 1
Co-authorsBrett Graham
2014James MH, Campbell EJ, Walker FR, Smith DW, Richardson HN, Hodgson DM, Dayas CV, 'Exercise reverses the effects of early life stress on orexin cell reactivity in male but not female rats', Frontiers in Behavioral Neuroscience, 8 (2014) [C1]
DOI10.3389/fnbeh.2014.00244
CitationsScopus - 2Web of Science - 2
Co-authorsDouglas Smith, Deborah Hodgson, Rohan Walker
2013James MH, Dayas CV, 'What about me ...? The PVT: a role for the paraventricular thalamus (PVT) in drug-seeking behavior', FRONTIERS IN BEHAVIORAL NEUROSCIENCE, 7 (2013) [C3]
DOI10.3389/fnbeh.2013.00018Author URL
CitationsScopus - 8Web of Science - 6
2013Cahif A, Parkinson GM, Dayas CV, Smith DW, 'Characterisation of mitochondrial DNA deletions by long-PCR in central nervous system regions of young, middle- and old-aged rats.', Current Aging Science, 6 232-238 (2013) [C1]
CitationsScopus - 1
Co-authorsDouglas Smith
2013Brown AL, Day TA, Dayas CV, Smith DW, 'Purity and Enrichment of Laser-Microdissected Midbrain Dopamine Neurons', BIOMED RESEARCH INTERNATIONAL, (2013) [C1]
DOI10.1155/2013/747938Author URL
CitationsScopus - 1
Co-authorsTrevor Day, Douglas Smith
2012James MH, Yeoh JW, Graham B, Dayas C, 'Insights for Developing Pharmacological Treatments for Psychostimulant Relapse Targeting Hypothalamic Peptide Systems.', Journal of Addiction Research and Therapy, 01 1-14 (2012)
Co-authorsBrett Graham
2012Yeoh JW, James MH, Jobling P, Bains JS, Graham BA, Dayas CV, 'Cocaine potentiates excitatory drive in the perifornical/lateral hypothalamus', Journal of Physiology, 590 3677-3689 (2012) [C1]
CitationsScopus - 11Web of Science - 10
Co-authorsBrett Graham, Phillip Jobling
2012Dayas CV, Smith DW, Dunkley PR, 'An emerging role for the mammalian Target of Rapamycin (mTOR) in 'pathological' protein translation: Relevance to cocaine addiction', Frontiers in Pharmacology, 3 1-12 (2012) [C1]
CitationsScopus - 9Web of Science - 7
Co-authorsPeter Dunkley, Douglas Smith
2011James MH, Charnley JL, Flynn JR, Smith DW, Dayas CV, 'Propensity to 'relapse' following exposure to cocaine cues is associated with the recruitment of specific thalamic and epithalamic nuclei', Neuroscience, 199 235-242 (2011) [C1]
CitationsScopus - 18Web of Science - 17
Co-authorsDouglas Smith
2011James MH, Charnley JL, Levi EM, Jones E, Yeoh JW, Smith DW, Dayas CV, 'Orexin-1 receptor signalling within the ventral tegmental area, but not the paraventricular thalamus, is critical to regulating cue-induced reinstatement of cocaine-seeking', International Journal of Neuropsychopharmacology, 14 684-690 (2011) [C1]
DOI10.1017/s1461145711000423
CitationsScopus - 44Web of Science - 42
Co-authorsDouglas Smith
2011Brown AL, Flynn JR, Smith DW, Dayas CV, 'Down-regulated striatal gene expression for synaptic plasticity-associated proteins in addiction and relapse vulnerable animals', International Journal of Neuropsychopharmacology, 14 1099-1110 (2011) [C1]
CitationsScopus - 11Web of Science - 9
Co-authorsDouglas Smith
2010James MH, Charnley JL, Jones E, Levi E, Yeoh JW, Flynn JR, et al., 'Cocaine- and amphetamine-regulated transcript (CART) signaling within the paraventricular thalamus modulates cocaine-seeking behaviour', Plos One, 5 e12980 (2010) [C1]
DOI10.1371/journal.pone.0012980
CitationsScopus - 23Web of Science - 21
Co-authorsDouglas Smith
2009Martin-Fardon R, Baptista MAS, Dayas CV, Weiss F, 'Dissociation of the effects of MTEP [3-[(2-methyl-1,3-thiazol-4-yl)ethynyl] piperidine] on conditioned reinstatement and reinforcement: Comparison between cocaine and a conventional reinforcer', Journal of Pharmacology and Experimental Therapeutics, 329 1084-1090 (2009) [C1]
DOI10.1124/jpet.109.151357
CitationsScopus - 52Web of Science - 49
2008Dayas C, McGranahan T, Martin-Fardon F, Weiss F, 'Stimuli Linked to Ethanol Availability Activate Hypothalamic CART and Orexin Neurons in a Reinstatement Model of Relapse', Biological Psychiatry, 63 152-157 (2008) [C1]
DOI10.1016/j.biopsych.2007.02.002
CitationsScopus - 95Web of Science - 93
2007Dayas C, Liu X, Simms J, Weiss F, 'Distinct Patterns of Neural Activation Associated with Ethanol Seeking: Effects of Naltrexone', Biological Psychiatry, 61 979-989 (2007) [C1]
DOI10.1016/j.biopsych.2006.07.034
CitationsScopus - 59Web of Science - 60
2006Xhao Y, Dayas C, Aujla H, Baptista MA, Martin-Fardon R, Weiss F, 'Activation of group II metabotropic glutamate receptors attenuates both stress and cue-induced ethanol-seeking and modulates c-fos expression in the hippocampus and amygdala', The Journal of Neuroscience, 26 9967-9974 (2006) [C1]
DOI10.1523/JNEUROSCI.2384-06.2006
CitationsScopus - 86Web of Science - 87
2005Breese GR, Chu K, Dayas C, Funk D, Knapp DJ, Koob GF, et al., 'Stress enhancement of craving during sobriety: A risk for relapse', Alcoholism: Clinical and Experimental Research, 29 185-195 (2005) [C1]
DOI10.1097/01.ALC.0000153544.83656.3C
CitationsScopus - 125Web of Science - 112
2004Dayas C, Buller KM, Day TA, 'Hypothalamic paraventricular nucleus neurons regulate medullary catecholamine cell responses to restraint stress', Journal of Comparative Neurology, 478 22-34 (2004) [C1]
DOI10.1002/cne.20259
CitationsScopus - 28Web of Science - 28
Co-authorsTrevor Day
2004Dayas C, Martin-Fardon R, Thorsell A, Weiss F, 'Chronic footshock, but not a physiological stressor, suppresses the alcohol deprivation effect in dependent rats', Alcohol and Alcoholism, 39 190-196 (2004) [C1]
DOI10.1093/alcalc/agh046
CitationsScopus - 14Web of Science - 13
2003Buller KM, Dayas C, Day TA, 'Descending pathways from the paraventricular nucleus contribute to the recruitment of brainstem nuclei following a systemic immune challenge', Neuroscience, 118 189-203 (2003) [C1]
DOI10.1016/S0306-4522(02)00808-4
CitationsScopus - 35Web of Science - 33
Co-authorsTrevor Day
2002Dayas C, Day TA, 'Opposing Roles For Medial And Central Amygdala In The Initiation Of Noradrenergic Cell Responses To A Psychological Stressor.', European Journal of Neuroscience, 15 1712-1718 (2002) [C1]
CitationsScopus - 51Web of Science - 43
Co-authorsTrevor Day
2001Buller K, Xu YY, Dayas C, Day T, 'Dorsal and ventral medullary catecholamine cell groups contribute differentially to systemic interleukin-1 beta-induced hypothalamic pituitary adrenal axis responses', NEUROENDOCRINOLOGY, 73 129-138 (2001)
DOI10.1159/000054629Author URL
CitationsWeb of Science - 63
2001Dayas CV, Buller KM, Day TA, 'Medullary neurones regulate hypothalamic corticotropin-releasing factor cell responses to an emotional stressor', NEUROSCIENCE, 105 707-719 (2001)
DOI10.1016/S0306-4522(01)00213-5Author URL
CitationsScopus - 70Web of Science - 61
2001Dayas CV, Buller KM, Crane JW, Xu Y, Day TA, 'Stressor categorization: Acute physical and psychological stressors elicit distinctive recruitment patterns in the amygdala and in medullary noradrenergic cell groups', European Journal of Neuroscience, 14 1143-1152 (2001) [C1]
CitationsScopus - 276Web of Science - 255
2000Dayas CV, Xu Y, Buller KM, Day TA, 'Effects of chronic oestrogen replacement on stress-induced activation of hypothalamic-pituitary-adrenal axis control pathways', JOURNAL OF NEUROENDOCRINOLOGY, 12 784-794 (2000)
DOI10.1046/j.1365-2826.2000.00527.xAuthor URL
CitationsScopus - 72Web of Science - 64
1999Dayas CV, Buller KM, Day TA, 'Neuroendocrine responses to an emotional stressor: Evidence for involvement of the medial but not the central amygdala', European Journal of Neuroscience, 11 2312-2322 (1999) [C1]
CitationsScopus - 213Web of Science - 201
Show 33 more journal articles

Conference (11 outputs)

YearCitationAltmetricsLink
2012James MH, Charnley JL, Levi EM, Dunkley PR, Smith DW, Dickson PW, Dayas CV, 'A role for the mTOR pathway in the development of addiction', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authorsPeter Dunkley, Douglas Smith, Phil Dickson
2012Brown AL, Flynn JR, Dayas CV, Smith DW, 'Altered gene expression in cell signalling pathways of midbrain dopamine neurons from addiction and relapse vulnerable animals', Drug and Alcohol Review: Abstracts of the Australasian Professional Society on Alcohol and other Drugs Conference 2012, Melbourne, Vic (2012) [E3]
Co-authorsDouglas Smith
2012Dayas CV, Quinn RK, Goldie BJ, Brown AM, Levi EM, Smith DW, Cairns MJ, 'Association of miRNAs with addiction-relevant synaptic plasticity genes', Abstract Book. Biological Psychiatry Australia Scientific Meeting, Parkville, Vic (2012) [E3]
Co-authorsMurray Cairns, Douglas Smith
2012Campbell EJ, James MH, Sominsky Bar L, Hodgson DM, Dayas CV, 'Adult stress unmasks altered orexin cell functioning in maternally separated rats: Implications for the development of psychopathologies', Abstract Book. Biological Psychiatry Australia Scientific Meeting, Parkville, Vic (2012) [E3]
Co-authorsDeborah Hodgson
2010Dayas CV, 'BRAIN MECHANISMS ASSOCIATED WITH THE DEVELOPMENT OF PSYCHOSTIMULANT ADDICTION', DRUG AND ALCOHOL REVIEW (2010) [E3]
Author URL
2008Dayas CV, 'The neurobiology of drug relapse: A role for hypothalamic 'feeding' peptides in drug relapse?', Australian and New Zealand Journal of Psychiatry, Newcastle, NSW (2008) [E3]
2007Dayas CV, McGranahan TM, Martin-Fardon R, Weiss F, 'Hypothalamic feeding-related peptides are recruited in a reinstatement model of ethanol relapse (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
2007Weiss F, Dayas CV, 'Alcohol cue exposure produces distinct patterns of neural activation implications for alcohol craving and relapse', ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, Chicago, IL (2007)
Author URL
2005Zhao Y, Dayas CV, Weiss F, 'Effects of the metabotropic Glutamate 2/3 agonist LY379268 on reinstatement of ethanol-seeking induced by alcohol-associated environmental stimuli and foot-shock stress', ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, Santa Barbara, CA (2005)
Author URL
CitationsWeb of Science - 1
2005Dayas CV, Zhao Y, Weiss F, ''Anti-relapse' effects of the metabotropic glutamate 2/3 agonist LY379268 am associated with increased c-fos expression in the central amygdala', ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, Santa Barbara, CA (2005)
Author URL
1999Day TA, Buller KM, Xu Y, Dayas CV, Crane JW, 'Separation of neural pathways mediating HPA axis responses to emotional and physical stressors', CONTROL MECHANISMS OF STRESS AND EMOTION: NEUROENDOCRINE-BASED STUDIES, KITAKYUSHU, JAPAN (1999)
Author URL
CitationsWeb of Science - 2
Show 8 more conferences
Edit

Grants and Funding

Summary

Number of grants22
Total funding$860,088

Click on a grant title below to expand the full details for that specific grant.


20151 grants / $10,000

The involvement of the lateral hypothalamic orexin system in motivational behaviours$10,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamMs Erin Campbell, Doctor Chris Dayas, Professor Deborah Hodgson
SchemeJennie Thomas Medical Research Travel Grant
RoleLead
Funding Start2015
Funding Finish2015
GNoG1401379
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20141 grants / $25,000

Modulation of emotion by gut signals to the brain$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Chris Dayas
SchemeProject Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1401518
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20136 grants / $90,596

Identifying novel pharmacological targets for drug relapse$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Chris Dayas
SchemeNear Miss Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300473
Type Of FundingInternal
CategoryINTE
UONY

Identifying novel pharmacological targets for drug relapse$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Chris Dayas
SchemeNear Miss
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300827
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Addictive drugs rewire the hypothalamus to drive relapse through brain 'reward' circuits$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Chris Dayas
SchemeNear Miss Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300474
Type Of FundingInternal
CategoryINTE
UONY

Addictive drugs rewire the hypothalamus to drive relapse through brain 'reward' circuits$10,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Chris Dayas
SchemeNear Miss
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300828
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

PhD Student Pulse Travel Award 'Dopamine 2013'$6,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamDoctor Chris Dayas
SchemeResearch Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300521
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

20124 grants / $53,211

Characterizing psychostimulant-induced synaptic plasticity in the hypothalamus$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Chris Dayas, Doctor Brett Graham
SchemeNear Miss Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200677
Type Of FundingInternal
CategoryINTE
UONY

Roles of post-transcriptional gene silencing in the functional regulation of neuronal gene expression and plasticity in schizophrenia$19,500

Funding body: Schizophrenia Research Institute

Funding bodySchizophrenia Research Institute
Project TeamConjoint Associate Professor Murray Cairns, Ms Belinda Goldie, Doctor Chris Dayas
SchemePostgraduate Research Scholarship
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200761
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Understanding the behavioural and neuroendocrine mechanisms of invasiveness in an avian system: do Indian mynahs display a dopaminergic-dependent invasion syndrome?$12,211

Funding body: University of Newcastle - Faculty of Science & IT

Funding bodyUniversity of Newcastle - Faculty of Science & IT
Project TeamDoctor Andrea Griffin, Doctor Chris Dayas, Doctor David Guez
SchemeStrategic Small Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1401098
Type Of FundingInternal
CategoryINTE
UONY

Addiction Research and Therapy, Embassy Suites Las Vegas, 20 - 22 August 2012$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamDoctor Chris Dayas
SchemeTravel Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200602
Type Of FundingInternal
CategoryINTE
UONY

20112 grants / $35,000

Brain Mechanisms Conferring Psychostimulant Addiction$25,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Chris Dayas, Emeritus Professor Peter Dunkley, Doctor Doug Smith
SchemeNear Miss Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1001052
Type Of FundingInternal
CategoryINTE
UONY

IMPLEN NanoPhotometer pearl$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamConjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Professor Alan Brichta, Emeritus Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Professor Ulli Schall, Associate Professor Phillip Dickson, Doctor Frederick Walker, Doctor Rick Thorne, Doctor Chris Dayas, Doctor Nikki Verrills, Doctor Janet Holt, Doctor Severine Roselli, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Associate Professor Liz Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Mr Dan Johnstone, Ms Belinda Goldie, Doctor Natalie Beveridge
SchemeEquipment Grant
RoleInvestigator
Funding Start2011
Funding Finish2011
GNoG1100030
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

20102 grants / $55,303

ABI 7500 Real Time PCR System $34,000

Funding body: NHMRC (National Health & Medical Research Council)

Characterising the synaptic physiology of orexin neurons in response to cocaine: Implications for drug relapse$21,303

Funding body: Hunter Children`s Research Foundation

Funding bodyHunter Children`s Research Foundation
Project TeamDoctor Chris Dayas, Doctor Brett Graham
SchemeResearch Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG0900151
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY

20081 grants / $398,978

Brain pathways underlying vulnerability to drug relapse$398,978

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Chris Dayas
SchemeProject Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0187592
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

20074 grants / $57,500

Characterisation of the brain mechanisms linking vulnerability to stress and vulnerability to drug addiction$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Trevor Day, Doctor Chris Dayas, Doctor Doug Smith
SchemeProject Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0187255
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

3D Imaging Software/Work station$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor David Pow, Doctor Chris Dayas, Doctor Phil Jobling, Associate Professor Derek Laver
SchemeEquipment Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188026
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Characterisation of the Brain Mechanisms linking vulnerability to stress and vulnerability to drug addiction$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Chris Dayas
SchemeEarly Career Researcher Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187312
Type Of FundingInternal
CategoryINTE
UONY

Molecular and cellular mechanisms underpinning drug relapse$7,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamDoctor Chris Dayas
SchemeNew Staff Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187726
Type Of FundingInternal
CategoryINTE
UONY

20061 grants / $134,500

Neural links between drug addiction and stress$134,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamDoctor Chris Dayas, Professor Trevor Day
SchemeTraining (Postdoctoral) Fellowships - C.J. Martin Biomedical Fellowships (Overseas)
RoleLead
Funding Start2006
Funding Finish2006
GNoG0187071
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY
Edit

Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2014Evidence Accumulation Models of Rodent Behaviour
Psychology, Faculty of Science and Information Technology
Co-Supervisor
2014Optogenetic Dissection of Hypothalamic Brain Circuitry and its Implications for Conditions of Motivated Behaviour
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2013Characterizing Changes in the Orexin System in Models of Neuropsychiatric Disease
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2012Role of miRNA in Addiction Vulnerability
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2011Ageing of the Somatic Motor Nervous System: A Mitochondrial and Nuclear Genome Perspective
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2010Drug-Induced Changes to the Lateral Hypothalamic Orexin Circuits and Downstream Projection Targets
Human Biology, Faculty of Health and Medicine
Principal Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2015Roles of Post-Transcriptional Gene Silencing in the Functional Regulation of Neuronal Gene Expression and Plasticity
Medical Science, Faculty of Health and Medicine
Co-Supervisor
2014The Role of Cocaine- and Amphetamine-Regulated Transcript (CART) and Orexin in Drug-Seeking and Addiction-Related Behaviours
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2012Molecular Correlates of Dopamine Signalling in Addiction Vulnerability
Human Biology, Faculty of Health and Medicine
Co-Supervisor
Edit

News

microscope

Microscope to shed light on mental health

April 30, 2015

A laser-equipped microscope that gives brain researchers unparalleled insight into mental illness has just been installed at the University of Newcastle.

Dr Chris Dayas

Positions

Senior Lecturer
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Casual Lecturer
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Anatomy

Contact Details

Emailchristopher.dayas@newcastle.edu.au
Phone(02) 4921 5618
Fax(02) 4921 7904

Office

RoomMS306C/D
BuildingMedical Sciences
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
Edit