2023 |
Poppi LA, Bigland MJ, Cresswell ET, Tabatabaee H, Lorincz D, Drury HR, et al., 'Molecular and Functional Changes to Postsynaptic Cholinergic Signaling in the Vestibular Sensory Organs of Aging C57BL/6 Mice.', J Gerontol A Biol Sci Med Sci, 78 920-929 (2023) [C1]
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Nova |
2023 |
Lawson EF, Ghosh A, Blanch V, Grupen CG, Aitken RJ, Lim R, et al., 'Establishment and characterization of oviductal organoids from farm and companion animals .', Biol Reprod, 108 854-865 (2023) [C1]
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Nova |
2023 |
Sherwood CP, Crovador R, Posar JA, Brichta N, Simunovic MP, Louie F, et al., 'Design Parameters and Human Biocompatibility Assessment Protocols for Organic Semiconducting Neural Interfaces: Toward a Printed Artificial Retina with Color Vision', ADVANCED MATERIALS INTERFACES, [C1]
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Nova |
2023 |
Lorincz D, Drury HR, Smith DW, Lim R, Brichta AM, 'Aged mice are less susceptible to motion sickness and show decreased efferent vestibular activity compared to young adults.', Brain and behavior, 13 e3064 (2023) [C1]
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Nova |
2022 |
Venkata VD, Jamaluddin MFB, Goad J, Drury HR, Tadros MA, Lim R, et al., 'Development and characterization of human fetal female reproductive tract organoids to understand Müllerian duct anomalies', Proceedings of the National Academy of Sciences of the United States of America, 119 (2022) [C1]
Müllerian ducts are paired tubular structures that give rise to most of the female repro- ductive organs. Any abnormalities in the development and differentiation of these ducts l... [more]
Müllerian ducts are paired tubular structures that give rise to most of the female repro- ductive organs. Any abnormalities in the development and differentiation of these ducts lead to anatomical defects in the female reproductive tract organs categorized as Müllerian duct anomalies. Due to the limited access to fetal tissues, little is understood of human reproductive tract development and the associated anomalies. Although organoids represent a powerful model to decipher human development and disease, such organoids from fetal reproductive organs are not available. Here, we developed organoids from human fetal fallopian tubes and uteri and compared them with their adult counterparts. Our results demonstrate that human fetal reproductive tract epithelia do not express some of the typical markers of adult reproductive tract epithelia. Furthermore, fetal organoids are grossly, histologically, and proteomically different from adult organoids. While external supplementation of WNT ligands or activators in culture medium is an absolute requirement for the adult reproductive tract organoids, fetal organoids are able to grow in WNT-deficient conditions. We also developed decellularized tissue scaffolds from adult human fallopian tubes and uteri. Transplantation of fetal organoids onto these scaffolds led to the regeneration of the adult fallopian tube and uterine epithelia. Importantly, suppression of Wnt signaling, which is altered in patients with Müllerian duct anomalies, inhibits the regenerative ability of human fetal organoids and causes severe anatomical defects in the mouse reproductive tract. Thus, our fetal organoids represent an important platform to study the underlying basis of human female reproductive tract development and diseases.
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Nova |
2022 |
Lorincz D, Poppi LA, Holt JC, Drury HR, Lim R, Brichta AM, 'The Long and Winding Road Vestibular Efferent Anatomy in Mice', Frontiers in Neural Circuits, 15 (2022) [C1]
The precise functional role of the Efferent Vestibular System (EVS) is still unclear, but the auditory olivocochlear efferent system has served as a reasonable model on the effect... [more]
The precise functional role of the Efferent Vestibular System (EVS) is still unclear, but the auditory olivocochlear efferent system has served as a reasonable model on the effects of a cholinergic and peptidergic input on inner ear organs. However, it is important to appreciate the similarities and differences in the structure of the two efferent systems, especially within the same animal model. Here, we examine the anatomy of the mouse EVS, from its central origin in the Efferent Vestibular Nucleus (EVN) of the brainstem, to its peripheral terminations in the vestibular organs, and we compare these findings to known mouse olivocochlear anatomy. Using transgenic mouse lines and two different tracing strategies, we examine central and peripheral anatomical patterning, as well as the anatomical pathway of EVS axons as they leave the mouse brainstem. We separately tag the left and right efferent vestibular nuclei (EVN) using Cre-dependent, adeno-associated virus (AAV)-mediated expression of fluorescent reporters to map their central trajectory and their peripheral terminal fields. We couple this with Fluro-Gold retrograde labeling to quantify the proportion of ipsi- and contralaterally projecting cholinergic efferent neurons. As in some other mammals, the mouse EVN comprises one group of neurons located dorsal to the facial genu, close to the vestibular nuclei complex (VNC). There is an average of just 53 EVN neurons with rich dendritic arborizations towards the VNC. The majority of EVN neurons, 55%, project to the contralateral eighth nerve, crossing the midline rostral to the EVN, and 32% project to the ipsilateral eighth nerve. The vestibular organs, therefore, receive bilateral EVN innervation, but without the distinctive zonal innervation patterns suggested in gerbil. Similar to gerbil, however, our data also suggest that individual EVN neurons do not project bilaterally in mice. Taken together, these data provide a detailed map of EVN neurons from the brainstem to the periphery and strong anatomical support for a dominant contralateral efferent innervation in mammals.
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Nova |
2022 |
Stitt IM, Wellings TP, Drury HR, Jobling P, Callister RJ, Brichta AM, Lim R, 'Properties of Deiters? neurons and inhibitory synaptic transmission in the mouse lateral vestibular nucleus', JOURNAL OF NEUROPHYSIOLOGY, 128 131-147 (2022) [C1]
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Nova |
2021 |
Quinn RK, Drury HR, Lim R, Callister RJ, Tadros MA, 'Differentiation of Sensory Neuron Lineage During the Late First and Early Second Trimesters of Human Foetal Development', NEUROSCIENCE, 467 28-38 (2021) [C1]
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Nova |
2021 |
Quinn RK, Drury HR, Cresswell ET, Tadros MA, Nayagam BA, Callister RJ, et al., 'Expression and Physiology of Voltage-Gated Sodium Channels in Developing Human Inner Ear', FRONTIERS IN NEUROSCIENCE, 15 (2021) [C1]
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Nova |
2021 |
Crovador R, Heim H, Cottam S, Feron K, Bhatia V, Louie F, et al., 'Advanced Control of Drug Delivery for in Vivo Health Applications via Highly Biocompatible Self-Assembled Organic Nanoparticles', ACS Applied Bio Materials, 4 6338-6350 (2021) [C1]
The use of nanostructured materials for targeted and controlled delivery of bioactive molecules is an attractive alternative to conventional drug administration protocols, enablin... [more]
The use of nanostructured materials for targeted and controlled delivery of bioactive molecules is an attractive alternative to conventional drug administration protocols, enabling selective targeting of diseased cells, lower administered dosages, and reduced systemic side effects. Although a variety of nanocarriers have been investigated in recent years, electroactive organic polymer nanoparticles present several exciting advantages. Here we demonstrate that thin films created from nanoparticles synthesized from violanthrone-79, an n-type semiconducting organic material, can incorporate and release dexamethasone in vitro in a highly controlled manner. By systematically altering the nanoparticle formation chemistry, we successfully tailored the size of the nanoparticles between 30 and 145 nm to control the initial amount of drug loaded into the organic particles. The biocompatibility of the different particles was tested using live/dead assays of dorsal root ganglion neurons isolated and cultured from mice, revealing that elevated levels of the sodium dodecyl sulfate surfactant used to create the smaller nanoparticles are cytotoxic; however, cell survival rates in nanoparticles larger than 45 nm exceed 86% and promote neurite growth and elongation. By manipulating the electrical stimulus applied to the electroactive nanoparticle films, we show an accelerated rate of drug release in comparison to passive release in aqueous media. Furthermore, pulsing the electrical stimulus was successfully used to selectively switch the accelerated release rate on and off. By combining the tuning of drug loading (through tailored nanoparticle synthesis) and drug release rate (through electrical stimulus protocols), we demonstrate a highly advanced control of drug delivery dosage in a biocompatible delivery vehicle. This work highlights the significant potential of electroactive organic nanoparticles for implantable devices that can deliver corticosteroids directly to the nervous system for the treatment of inflammation associated with neurological disorders, presenting a translatable pathway toward precision nanomedicine approaches for other drugs and diseases.
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Nova |
2021 |
Sherwood CP, Elkington DC, Dickinson MR, Belcher WJ, Dastoor PC, Feron K, et al., 'Organic semiconductors for optically triggered neural interfacing: The impact of device architecture in determining response magnitude and polarity', IEEE Journal of Selected Topics in Quantum Electronics, 27 (2021) [C1]
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Nova |
2020 |
Leyssens L, Vinck B, Van Der Straeten C, De Smet K, Dhooge I, Wuyts FL, et al., 'The Ototoxic Potential of Cobalt From Metal-on-Metal Hip Implants: Objective Auditory and Vestibular Outcome', EAR AND HEARING, 41 217-230 (2020) [C1]
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Nova |
2020 |
Poppi LA, Holt JC, Lim R, Brichta AM, 'A review of efferent cholinergic synaptic transmission in the vestibular periphery and its functional implications', Journal of Neurophysiology, 123 608-629 (2020) [C1]
It has been over 60 years since peripheral efferent vestibular terminals were first identified in mammals, and yet the function of the efferent vestibular system remains obscure. ... [more]
It has been over 60 years since peripheral efferent vestibular terminals were first identified in mammals, and yet the function of the efferent vestibular system remains obscure. One reason for the lack of progress may be due to our deficient understanding of the peripheral efferent synapse. Although vestibular efferent terminals were identified as cholinergic less than a decade after their anatomical characterization, the cellular mechanisms that underlie the properties of these synapses have had to be inferred. In this review we examine how recent mammalian studies have begun to reveal both nicotinic and muscarinic effects at these terminals and therefore provide a context for fast and slow responses observed in classic electrophysiological studies of the mammalian efferent vestibular system, nearly 40 years ago. Although incomplete, these new results together with those of recent behavioral studies are helping to unravel the mysterious and perplexing action of the efferent vestibular system. Armed with this information, we may finally appreciate the behavioral framework in which the efferent vestibular system operates.
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Nova |
2020 |
Al-Mudhaffer MF, Holmes NP, Kumar P, Barr MG, Cottam S, Crovador R, et al., 'Relating nanoscale structure to optoelectronic functionality in multiphase donor-acceptor nanoparticles for printed electronics applications', MRS Communications, 10 600-608 (2020) [C1]
This work investigated the photophysical pathways for light absorption, charge generation, and charge separation in donor-acceptor nanoparticle blends of poly(3-hexylthiophene) an... [more]
This work investigated the photophysical pathways for light absorption, charge generation, and charge separation in donor-acceptor nanoparticle blends of poly(3-hexylthiophene) and indene-C60-bisadduct. Optical modeling combined with steady-state and time-resolved optoelectronic characterization revealed that the nanoparticle blends experience a photocurrent limited to 60% of a bulk solution mixture. This discrepancy resulted from imperfect free charge generation inside the nanoparticles. High-resolution transmission electron microscopy and chemically resolved X-ray mapping showed that enhanced miscibility of materials did improve the donor-acceptor blending at the center of the nanoparticles; however, a residual shell of almost pure donor still restricted energy generation from these nanoparticles.
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Nova |
2019 |
de Oliveira RB, Petiz LL, Lim R, Lipski J, Gravina FS, Brichta AM, et al., 'Crosstalk between mitochondria, calcium channels and actin cytoskeleton modulates noradrenergic activity of locus coeruleus neurons.', Journal of neurochemistry, 149 471-487 (2019) [C1]
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Nova |
2019 |
'Vestibular System (2019)
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2019 |
Mattei C, Lim R, Drury H, Nasr B, Li Z, Tadros MA, et al., 'Generation of Vestibular Tissue-Like organoids From Human Pluripotent Stem Cells Using the Rotary Cell Culture System', FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 7 (2019) [C1]
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Nova |
2019 |
Curthoys IS, Grant JW, Pastras CJ, Brown DJ, Burgess AM, Brichta AM, Lim R, 'A review of mechanical and synaptic processes in otolith transduction of sound and vibration for clinical VEMP testing.', Journal of neurophysiology, 122 259-176 (2019) [C1]
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Nova |
2019 |
Ogier JM, Burt RA, Drury HR, Lim R, Nayagam BA, 'Organotypic culture of neonatal murine inner ear explants', Frontiers in Cellular Neuroscience, 13 1-12 (2019) [C1]
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Nova |
2018 |
Poppi LA, Tabatabaee H, Drury HR, Jobling P, Callister RJ, Migliaccio AA, et al., 'ACh-induced hyperpolarization and decreased resistance in mammalian type II vestibular hair cells', Journal of Neurophysiology, 119 312-325 (2018) [C1]
In the mammalian vestibular periphery, electrical activation of the efferent vestibular system (EVS) has two effects on afferent activity: 1) it increases background afferent disc... [more]
In the mammalian vestibular periphery, electrical activation of the efferent vestibular system (EVS) has two effects on afferent activity: 1) it increases background afferent discharge and 2) decreases afferent sensitivity to rotational stimuli. Although the cellular mechanisms underlying these two contrasting afferent responses remain obscure, we postulated that the reduction in afferent sensitivity was attributed, in part, to the activation of a9- containing nicotinic acetylcholine (ACh) receptors (a9*nAChRs) and small-conductance potassium channels (SK) in vestibular type II hair cells, as demonstrated in the peripheral vestibular system of other vertebrates. To test this hypothesis, we examined the effects of the predominant EVS neurotransmitter ACh on vestibular type II hair cells from wild-type (wt) and a9-subunit nAChR knockout (a9 -/- ) mice. Immunostaining for choline acetyltransferase revealed there were no obvious gross morphological differences in the peripheral EVS innervation among any of these strains. ACh application onto wt type II hair cells, at resting potentials, produced a fast inward current followed by a slower outward current, resulting in membrane hyperpolarization and decreased membrane resistance. Hyperpolarization and decreased resistance were due to gating of SK channels. Consistent with activation of a9*nAChRs and SK channels, these ACh-sensitive currents were antagonized by the a9*nAChR blocker strychnine and SK blockers apamin and tamapin. Type II hair cells from a9 -/- mice, however, failed to respond to ACh at all. These results confirm the critical importance of a9nAChRs in efferent modulation of mammalian type II vestibular hair cells. Application of exogenous ACh reduces electrical impedance, thereby decreasing type II hair cell sensitivity. NEW & NOTEWORTHY Expression of a9 nicotinic subunit was crucial for fast cholinergic modulation of mammalian vestibular type II hair cells. These findings show a multifaceted efferent mechanism for altering hair cell membrane potential and decreasing membrane resistance that should reduce sensitivity to hair bundle displacements.
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Nova |
2018 |
Poppi LA, Tabatabaee H, Jobling P, Callister RJ, Migliaccio AA, Jordan PM, et al., 'ACh-induced hyperpolarization and decreased resistance in mammalian type II vestibular hair cells (vol 119, pg 312, 2018)', JOURNAL OF NEUROPHYSIOLOGY, 120 385-385 (2018)
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2018 |
Feron K, Lim R, Sherwood C, Keynes A, Brichta A, Dastoor PC, 'Organic Bioelectronics: Materials and Biocompatibility.', International Journal of Molecular Sciences, 19 (2018) [C1]
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Nova |
2017 |
Wellings TP, Brichta AM, Lim R, 'Altered neurofilament protein expression in the lateral vestibular nucleus in Parkinson s disease', Experimental Brain Research, 235 3695-3708 (2017) [C1]
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Nova |
2017 |
Burrows T, Goldman S, Pursey K, Lim R, 'Is there an association between dietary intake and academic achievement: a systematic review', Journal of Human Nutrition and Dietetics, 30 117-140 (2017) [C1]
Background: The majority of literature examining the effect of dietary behaviour on academic achievement has focused on breakfast consumption only. Here, we aim to systematically ... [more]
Background: The majority of literature examining the effect of dietary behaviour on academic achievement has focused on breakfast consumption only. Here, we aim to systematically review the literature investigating the broader effects of dietary intake and behaviours on school-aged children's academic achievement. Methods: A search was undertaken across seven databases using keywords. For studies to be included, they needed to be conducted in: school-aged children (5¿18 years); assess and report: (i) a measure of academic performance; (ii) a measure of dietary intake/behaviour; and (iii) the association between dietary intake/behaviours and academic performance. Forty studies were included in the review. Results: The majority of studies were cross-sectional in design (n = 33) and studied children aged >10 years, with very few reports in younger age groups. More than 30 different dietary assessment tools were used, with only 40% of those using a validated/standardised assessment method. Half the studies collected outcomes of academic achievement objectively from a recognised educational authority, whereas 10 studies used self-reported measures. The dietary outcomes most commonly reported to have positive associations with academic achievement were: breakfast consumption (n = 12) and global diet quality/meal patterns (n = 7), whereas negative associations reported with junk/fast food (n = 9). Conclusions: This review highlights that moderate associations exist for dietary intakes characterised by regular breakfast consumption, lower intakes of energy-dense, nutrient-poor foods and overall diet quality with respect to outcomes of academic achievement. Future studies should consider the use of validated dietary assessment methods and standardised reporting of academic achievement.
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Nova |
2016 |
Lim R, Brichta AM, 'Anatomical and physiological development of the human inner ear.', Hearing research, 338 9-21 (2016) [C1]
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Nova |
2016 |
Rabbitt RD, Brichta AM, Tabatabaee H, Boutros PJ, Ahn JH, Della Santina CC, et al., 'Heat pulse excitability of vestibular hair cells and afferent neurons', Journal of Neurophysiology, 116 825-843 (2016) [C1]
In the present study we combined electrophysiology with optical heat pulse stimuli to examine thermodynamics of membrane electrical excitability in mammalian vestibular hair cells... [more]
In the present study we combined electrophysiology with optical heat pulse stimuli to examine thermodynamics of membrane electrical excitability in mammalian vestibular hair cells and afferent neurons. We recorded whole cell currents in mammalian type II vestibular hair cells using an excised preparation (mouse) and action potentials (APs) in afferent neurons in vivo (chinchilla) in response to optical heat pulses applied to the crista (¿T ¿ 0.25°C per pulse). Afferent spike trains evoked by heat pulse stimuli were diverse and included asynchronous inhibition, asynchronous excitation, and/or phase-locked APs synchronized to each infrared heat pulse. Thermal responses of membrane currents responsible for APs in ganglion neurons were strictly excitatory, with Q10 ¿ 2. In contrast, hair cells responded with a mix of excitatory and inhibitory currents. Excitatory hair cell membrane currents included a thermoelectric capacitive current proportional to the rate of temperature rise (dT/dt) and an inward conduction current driven by ¿T. An iberiotoxin-sensitive inhibitory conduction current was also evoked by ¿T, rising in <3 ms and decaying with a time constant of ~24 ms. The inhibitory component dominated whole cell currents in 50% of hair cells at -68 mV and in 67% of hair cells at -60 mV. Responses were quantified and described on the basis of first principles of thermodynamics. Results identify key molecular targets underlying heat pulse excitability in vestibular sensory organs and provide quantitative methods for rational application of optical heat pulses to examine protein biophysics and manipulate cellular excitability.
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Nova |
2015 |
Tadros MA, Lim R, Hughes DI, Brichta AM, Callister RJ, 'Electrical maturation of spinal neurons in the human fetus: Comparison of ventral and dorsal horn', Journal of Neurophysiology, 114 2661-2671 (2015) [C1]
The spinal cord is critical for modifying and relaying sensory information to, and motor commands from, higher centers in the central nervous system to initiate and maintain conte... [more]
The spinal cord is critical for modifying and relaying sensory information to, and motor commands from, higher centers in the central nervous system to initiate and maintain contextually relevant locomotor responses. Our understanding of how spinal sensorimotor circuits are established during in utero development is based largely on studies in rodents. In contrast, there is little functional data on the development of sensory and motor systems in humans. Here, we use patch-clamp electrophysiology to examine the development of neuronal excitability in human fetal spinal cords (10¿18 wk gestation; WG). Transverse spinal cord slices (300 µm thick) were prepared, and recordings were made, from visualized neurons in either the ventral (VH) or dorsal horn (DH) at 32°C. Action potentials (APs) could be elicited in VH neurons throughout the period examined, but only after 16 WG in DH neurons. At this age, VH neurons discharged multiple APs, whereas most DH neurons discharged single APs. In addition, at 16¿18 WG, VH neurons also displayed larger AP and after-hyperpolarization amplitudes than DH neurons. Between 10 and 18 WG, the intrinsic properties of VH neurons changed markedly, with input resistance decreasing and AP and after-hyperpolarization amplitudes increasing. These findings are consistent with the hypothesis that VH motor circuitry matures more rapidly than the DH circuits that are involved in processing tactile and nociceptive information.
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Nova |
2014 |
Lim R, Drury HR, Tadros MA, Callister RJ, Brichta AM, Camp AJ, 'Preliminary Characterization of Voltage-Activated Whole-Cell Currents in Developing Human Vestibular Hair Cells and Calyx Afferent Terminals', Journal of the Association for Research in Otolaryngology, (2014) [C1]
We present preliminary functional data from human vestibular hair cells and primary afferent calyx terminals during fetal development. Whole-cell recordings were obtained from hai... [more]
We present preliminary functional data from human vestibular hair cells and primary afferent calyx terminals during fetal development. Whole-cell recordings were obtained from hair cells or calyx terminals in semi-intact cristae prepared from human fetuses aged between 11 and 18 weeks gestation (WG). During early fetal development (11-14 WG), hair cells expressed whole-cell conductances that were qualitatively similar but quantitatively smaller than those observed previously in mature rodent type II hair cells. As development progressed (15-18 WG), peak outward conductances increased in putative type II hair cells but did not reach amplitudes observed in adult human hair cells. Type I hair cells express a specific low-voltage activating conductance, G. A similar current was first observed at 15 WG but remained relatively small, even at 18 WG. The presence of a "collapsing" tail current indicates a maturing type I hair cell phenotype and suggests the presence of a surrounding calyx afferent terminal. We were also able to record from calyx afferent terminals in 15-18 WG cristae. In voltage clamp, these terminals exhibited fast inactivating inward as well as slower outward conductances, and in current clamp, discharged a single action potential during depolarizing steps. Together, these data suggest the major functional characteristics of type I and type II hair cells and calyx terminals are present by 18 WG. Our study also describes a new preparation for the functional investigation of key events that occur during maturation of human vestibular organs. © 2014 The Author(s).
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Nova |
2013 |
Tung VWK, Di Marco S, Lim R, Brichta AM, Camp AJ, 'An Isolated Semi-intact Preparation of the Mouse Vestibular Sensory Epithelium for Electrophysiology and High-resolution Two-photon Microscopy', Journal of Visualized Experiments, (2013) [C1]
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Nova |
2013 |
Hübner PP, Lim R, Brichta AM, Migliaccio AA, 'Glycine Receptor Deficiency and Its Effect on the Horizontal Vestibulo-ocular Reflex: a Study on the SPD1J Mouse', Journal of the Association for Research in Otolaryngology, 14 249-259 (2013) [C1]
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Nova |
2012 |
De Oliveira R, Gravina FS, Lim R, Brichta AM, Callister RJ, Van Helden DF, 'Heterogeneous responses to antioxidants in noradrenergic neurons of the Locus coeruleus indicate differing susceptibility to free radical content', Oxidative Medicine and Cellular Longevity, 2012 820285 (2012) [C1]
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Nova |
2011 |
De Oliveira R, Gravina FS, Lim R, Brichta AM, Callister RJ, Van Helden DF, 'Developmental changes in pacemaker currents in mouse locus coeruleus neurons', Brain Research, 1425 27-36 (2011) [C1]
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Nova |
2011 |
Lim R, McPherson AE, Donne SW, Callister RJ, Brichta AM, 'Potassium accumulation between type I hair cells and calyx terminals in mouse crista', Experimental Brain Research, 210 607-621 (2011) [C1]
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Nova |
2010 |
Lim R, Camp AJ, Walsh MA, Callister RJ, Brichta AM, 'In vitro whole-cell conductances recorded from developing human cristae.', J Vestib Res, 285-286 (2010)
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2010 |
Lim R, Stitt IM, Camp AJ, Walsh MA, Callister RJ, Brichta AM, 'Inhibitory synaptic transmission in the lateral vestibular nucleus.', J. Vestib. Res, 286-287 (2010)
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2010 |
Lim R, Callister RJ, Brichta AM, 'An increase in glycinergic quantal amplitude and frequency during early vestibular compensation in mouse', Journal of Neurophysiology, 103 16-24 (2010) [C1]
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Nova |
2010 |
De Oliveira R, Graham BA, Howlett MC, Gravina FS, Oliveira MW, Imtiaz MS, et al., 'Ketamine anesthesia helps preserve neuronal viability', Journal of Neuroscience Methods, 189 230-232 (2010) [C1]
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Nova |
2010 |
Camp AJ, Lim R, Anderson WB, Schofield PR, Callister RJ, Brichta AM, 'Attenuated glycine receptor function reduces excitability of mouse medial vestibular nucleus neurons', Neuroscience, 170 348-360 (2010) [C1]
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Nova |
2008 |
Jobling P, Lim R, 'Anatomical and physiological properties of pelvic ganglion neurons in female mice', Autonomic Neuroscience: Basic & Clinical, 140 30-39 (2008) [C1]
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Nova |
2004 |
Lim R, Hoang P, Berger AJ, 'Blockade of glycine transporter-1 (GLYT-1) potentiates NMDA receptor-mediated synaptic transmission in hypoglossal motorneurons', Journal of Neurophysiology, 92 2530-2537 (2004) [C1]
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2003 |
Lim R, Oleskevich S, Few AP, Leao RN, Walmsley B, 'Glycinergic mIPSCs in mouse and rat brainstem auditory nuclei: modulation by ruthenium red and the role of calcium stores', The Journal of Physiology, 546 691-699 (2003) [C1]
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2000 |
Lim R, Alvarez FJ, Walmsley BJ, 'GABA mediates presynaptic inhibition at glycinergic synapses in a rat auditory brainstem nucleus', J Physiol., 525 Pt 2 447-459 (2000) [C1]
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1999 |
Lim R, Alvarez FJ, Walmsley B, 'Quantal size is correlated with receptor cluster area at glycinergic synapses in the rat brainstem.', J Physiol., 516 ( Pt 2) 505-512 (1999) [C1]
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1998 |
Bellingham MC, Lim R, Walmsley B, 'Developmental changes in EPSC quantal size and quantal content at a central glutamatergic synapse in rat.', J Physiol., 511 ( Pt 3) 861.-869. (1998) [C1]
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