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Career Summary

Biography

I work both in the School of Biomedical Sciences and Pharmacy Medical Sciences Building and at the Mothers and Babies Research Centre, JHH campus. We are also part of Hunter Medical Research Institute and strongly support the activities of HMRI.

Research activities: Since moving to Newcastle in 2005, I have developed research programme examining the effects of stressors on neurosteroid production during pregnancy and at the fetal to neonatal transition. The overall goal of this work is to develop neurosteroid replacement strategies for reducing neonatal brain injury. Our team 7 staff and students including 3 PhD students. We have major joint projects within the Mothers and Babies Research Centre with Associate Professor Zakar, continuing my long standing interest in prevention of preterm labour. We also work with Professor E Lumbers, FAA, in a major collaboration with her that will examine the role of the uterine prorenin/renin receptor system in the control of cyclooxygenase-2 (COX-2) levels at labour onset.

Teaching work: I coordinate 3 pharmacology courses per year in the B. Biomedical Science and Master of Pharmacy programmes. One course is delivered entirely online and attracts students from around the country that are interested in gaining a pharmacology qualification.

Qualifications

  • PhD (Physiology), Monash University, 06/12/1989
  • Bachelor of Science (Honours), University of Adelaide, 09/07/1982

Research

Research keywords

  • Fetal Physiology
  • Neuroendocrinology
  • Pregnancy
  • Preterm labour

Research expertise

Topics include fetal and neonatal physiology. Endocrinology of pregnancy, birth and preterm labour. Animal models in pregnancy research. Improved therapies for the treatment of preterm labour.

Fields of Research

CodeDescriptionPercentage
111400Paediatrics And Reproductive Medicine50
110399Clinical Sciences Not Elsewhere Classified35
060199Biochemistry And Cell Biology Not Elsewhere Classified15

Memberships

Committee/Associations (relevant to research).

  • Grant Review Panel 3B - NH&MRC
  • Member - Perinatal Society of Australian and NZ

Editorial Board.

  • Board member - Neuroendocrinology

Invitations

Protective role of neurosteroids in the perinatal brain
Congress on Neuroendocrinology, United States (Conference Presentation - non published.)
2006
New approaches to the prevention of preterm labour
Perinatal Society of Australia and New Zealand, Australia (Conference Presentation - non published.)
1999

Administrative

Administrative expertise

Course co-oridinatior 3 courses (2006& 2007 in Pharmacy and Biomed Sci. programmes. Member of the NH&MRC grant review panel. Member of the PSANZ abstract and student prize panels. Member of the Animal Ethics committee.

Teaching

Teaching keywords

  • Endocrinology
  • Pharmacology
  • Reproduction

Teaching expertise

Phamarcology with particular knowledge of reproduction and pregnancy. pharamcology and the endocrine system, sex hormones and HRT. Endocrine and reproductive physiology.

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Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (87 outputs)

YearCitationAltmetricsLink
2014Brunton PJ, Russell JA, Hirst JJ, 'Allopregnanolone in the brain: Protecting pregnancy and birth outcomes', PROGRESS IN NEUROBIOLOGY, 113 106-136 (2014) [C1]
2014Hirst JJ, Kelleher MA, Walker DW, Palliser HK, 'Neuroactive steroids in pregnancy: Key regulatory and protective roles in the foetal brain', JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 139 144-153 (2014)
2014Cumberland AL, Palliser HK, Hirst JJ, ' Increased placental neurosteroidogenic gene expression precedes poor outcome in the preterm guinea pig', Journal of Developmental Origins of Health and Disease, 5 74-78 (2014)
2014Hutton LC, Yan E, Yawno T, Castillo-Melendez M, Hirst JJ, Walker DW, 'Injury of the Developing Cerebellum: A Brief Review of the Effects of Endotoxin and Asphyxial Challenges in the Late Gestation Sheep Fetus.', Cerebellum, (2014)
2014Palliser HK, Kelleher MA, Welsh TN, Zakar T, Hirst JJ, 'Mechanisms Leading to Increased Risk of Preterm Birth in Growth-Restricted Guinea Pig Pregnancies', REPRODUCTIVE SCIENCES, 21 269-276 (2014)
2014Hirst JJ, Kelleher MA, Walker DW, Palliser HK, 'Neuroactive steroids in pregnancy: Key regulatory and protective roles in the foetal brain', Journal of Steroid Biochemistry and Molecular Biology, 139 144-153 (2014)
2014Welsh TN, Hirst JJ, Palliser H, Zakar T, 'Progesterone receptor expression declines in the guinea pig uterus during functional progesterone withdrawal and in response to prostaglandins.', PLoS One, 9 e105253 (2014)
2013Bennett GA, Palliser HK, Saxby B, Walker DW, Hirst JJ, 'Effects of Prenatal Stress on Fetal Neurodevelopment and Responses to Maternal Neurosteroid Treatment in Guinea Pigs', DEVELOPMENTAL NEUROSCIENCE, 35 416-426 (2013) [C1]
2013Mitchell CM, Sykes SD, Pan X, Pringle KG, Lumbers ER, Hirst JJ, Zakar T, 'Inflammatory and steroid receptor gene methylation in the human amnion and decidua', JOURNAL OF MOLECULAR ENDOCRINOLOGY, 50 267-277 (2013) [C1]
2013Kelleher MA, Hirst JJ, Palliser HK, 'Changes in neuroactive steroid concentrations after preterm delivery in the guinea pig', Reproductive Sciences, 20 1365-1375 (2013) [C1]
2012Palliser HK, Yates DM, Hirst JJ, 'Progesterone receptor isoform expression in response to in utero growth restriction in the fetal guinea pig brain', Neuroendocrinology, 96 60-67 (2012) [C1]

Co-authors: Hannah Palliser

2012Welsh TN, Paul JW, Palliser HK, Tabatabaeehatambakhsh SH, Hirst JJ, Mesiano S, Zakar T, '15-hydroxyprostaglandin dehydrogenase expression and localization in guinea pig gestational tissues during late pregnancy and parturition', Reproductive Sciences, 19 1099-1109 (2012) [C1]
2012Fleiss B, Parkington HC, Coleman HA, Dickinson H, Yawno T, Castillo-Melendez M, et al., 'Effect of maternal administration of allopregnanolone before birth asphyxia on neonatal hippocampal function in the spiny mouse', Brain Research, 1433 9-19 (2012) [C1]
2012Dyson RM, Palliser HK, Kelleher MA, Hirst JJ, Wright IM, 'The guinea pig as an animal model for studying perinatal changes in microvascular function', Pediatric Research, 71 20-24 (2012) [C1]
2012Welsh T, Paul J, Palliser H, Hirst J, Mesiano S, Zakar T, 'PGDH Expression Decreases at Term before Labor Onset in Guinea Pig Fetal Membranes', REPRODUCTIVE SCIENCES, 19 192A-192A (2012) [C3]
2012Mitchell CM, Chai S, Madsen G, Hirst JJ, Zakar T, 'Bivalent Epigenetic Modifications Regulate PTGS2 Expression during Gestation in the Amnion', REPRODUCTIVE SCIENCES, 19 299A-299A (2012) [E3]
2012Welsh T, Caritis S, Hirst J, Mesiano S, Zakar T, 'Progesterone Withdrawal in the Pregnant Guinea Pig Is Mediated by Decreased Uterine PR Expression and Stimulated by Prostaglandins In Vivo', REPRODUCTIVE SCIENCES, 19 192A-192A (2012) [E3]
2011Kelleher MA, Palliser HK, Walker DW, Hirst JJ, 'Sex-dependent effect of a low neurosteroid environment and intrauterine growth restriction on foetal guinea pig brain development', Journal of Endocrinology, 208 301-309 (2011) [C1]
2011Mitchell CM, Johnson R, Bisits AM, Hirst JJ, Zakar T, 'PTGS2 (Prostaglandin Endoperoxide Synthase-2) expression in term human amnion in vivo involves rapid mRNA turnover, polymerase-II 5 '-pausing, and glucocorticoid transrepression', Endocrinology, 152 2113-2122 (2011) [C1]
2011Pringle KG, Zakar T, Roach DM, Mitchell CM, Hirst JJ, Lumbers ER, 'Molecular evidence of a (pro)renin/(pro)renin receptor system in human intrauterine tissues in pregnancy and its association with PGHS-2', Journal of the Renin-Angiotensin-Aldosterone System, 12 304-310 (2011) [C1]
2011Marques FZ, Pringle KG, Conquest AL, Hirst JJ, Markus MA, Sarris M, et al., 'Molecular characterization of renin-angiotensin system components in human intrauterine tissues and fetal membranes from vaginal delivery and cesarean section', Placenta, 32 214-221 (2011) [C1]
2011Yawno T, Yan EB, Hirst JJ, Walker DW, 'Neuroactive steroids induce changes in fetal sheep behavior during normoxic and asphyxic states', Stress, 14 13-22 (2011) [C1]
2011Frye CA, Hirst JJ, Brunton PJ, Russell JA, 'Neurosteroids for a successful pregnancy', Stress, 14 1-5 (2011) [C3]
2010Palliser HK, Zakar T, Symonds IM, Hirst JJ, 'Progesterone receptor isoform expression in the guinea pig myometrium from normal and growth restricted pregnancies', Reproductive Sciences, 17 776-782 (2010) [C1]
2010McKendry AA, Palliser HK, Yates DM, Walker DW, Hirst JJ, 'The effect of betamethasone treatment on neuroactive steroid synthesis in a foetal guinea pig model of growth restriction', Journal of Neuroendocrinology, 22 166-174 (2010) [C1]
2010Dellios NL, Lappas M, Young IR, Palliser HK, Hirst JJ, Oliva K, et al., 'Increased expression of alpha-enolase in cervico-vaginal fluid during labour', European Journal of Obstetrics Gynecology and Reproductive Biology, 153 16-22 (2010) [C1]
2009Yawno T, Hirst JJ, Castillo-Melendez M, Walker DW, 'Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain', Neuroscience, 163 838-847 (2009) [C1]
2009Vu TT, Hirst JJ, Stark MJ, Wright IM, Palliser HK, Hodyl NA, Clifton VL, 'Changes in human placental 5 alpha-reductase isoenzyme expression with advancing gestation: Effects of fetal sex and glucocorticoid exposure', Reproduction Fertility and Development, 21 599-607 (2009) [C1]
2009Winnall WR, Muir JA, Liew S, Hirst JJ, Meachem SJ, Hedger MP, 'Effects of chronic celecoxib on testicular function in normal and lipopolysaccharide-treated rats', International Journal of Andrology, 32 542-555 (2009) [C1]
2009Hirst JJ, Walker DW, Yawno T, Palliser HK, 'Stress in pregnancy: A role for neuroactive steroids in protecting the fetal and neonatal brain', Developmental Neuroscience, 31 363-377 (2009) [C1]
2008Hirst JJ, Palliser HK, Roach DM, Yawno T, Walker DW, 'Neurosteroids in the fetus and neonate: Potential protective role in compromised pregnancies', Neurochemistry International, 52 602-610 (2008) [C1]
2008Westcott KT, Hirst JJ, Ciurej I, Walker DW, Wlodek ME, 'Brain allopregnanolone in the fetal and postnatal rat in response to uteroplacental insufficiency', Neuroendocrinology, 88 287-292 (2008) [C1]
2007Young R, Rice GE, Palliser HK, Ayhan M, Dellios NL, Hirst JJ, 'Identification of bactenecin-1 in cervicovaginal fluid by two-dimensional electrophoresis in an ovine model of preterm labour', Proteomics, 7 281-288 (2007) [C1]
2007Smith R, Van Helden DF, Hirst JJ, Zakar T, Read MA, Chan EC, et al., 'Pathological interactions with the timing of birth and uterine activation', Australian & New Zealand Journal of Obstetrics & Gynaecology, 47 430-437 (2007) [C1]
2007Yawno T, Yan EB, Walker DW, Hirst JJ, 'Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep', Neuroscience, 146 1726-1733 (2007) [C1]
2007Winnall WR, Ali U, O'Bryan MK, Hirst JJ, Whiley PAF, Muir JA, Hedger MP, 'Constitutive expression of prostaglandin-endoperoxide synthase 2 by somatic and spermatogenic cells is responsible for prostaglandin E2 production in the adult rat testis', Biology of Reproduction, 76 759-768 (2007) [C1]
2007Hutton LC, Yan E, Yawno T, Castillo-Melendez M, Hirst JJ, Walker DW, 'Injury of the developing cerebellum: A brief review of the effects of endotoxin and asphyxial challenges in the late gestation sheep fetus.', Cerebellum (London, England), 1-10 (2007)
2006Hirst JJ, Yawno T, Nguyen P, Walker DW, 'Stress in Pregnancy Activates Neurosteroid Production in the Fetal Brain', Neuroendocrinology, 84 264-274 (2006) [C1]
2006Palliser HK, Dellios N, Escalona R, Ooi G, Rice GE, Hirst J, Young IR, 'Labor-Associated Regulation of Prostaglandin E and F Synthesis and Action in the Ovine Amnion and Cervix', Reproductive Sciences, 13 19-24 (2006) [C1]
2006Billiards SS, Guyen PN, Scheerlinck J-P, Phillips DJ, Canny BJ, Walker DW, Hirst JJ, 'Hypoxia potentiates endotoxin-induced allopregnanolone concentrations in the newborn brain', Biology of the Neonate, 90 258-267 (2006) [C1]
2006Ochsenkuhn R, O'Connor AE, Hirst JJ, Baker HWG, De Kretser DM, Hedger MP, 'The relationship between immunosuppressive activity and immunoregulatory cytokines in seminal plasma: Influence of sperm autoimmunity and seminal leukocytes', Journal of reproductive immunology, 71 57-74 (2006) [C1]
2005Hirst JJ, Parkington HC, Young IR, Palliser HK, Peri KG, Olsen DM, 'Delay of preterm birth in sheep by THG113.31, a prostaglandin F2[a] receptor antagonist', American Journal of Obstetrics and Gynecology, 193 256-266 (2005) [C1]
2005Palliser HK, Hirst J, Ooi GT, Rice GE, Escalona RM, Dellios NL, et al., 'Prostaglandin E and F receptor expression and myometrial sensitivity at labour onset in sheep', Biology of Reproduction, 72 937-943 (2005) [C1]
2005Azari MF, Profyris C, Le Grande MR, Lopes ES, Hirst J, Petratos S, Cheema S, 'Effects of intraperitoneal injection of Rofecoxib in a mouse model of ALS', European Journal of Neurology, 12 357-364 (2005) [C1]
2005Manuepillai U, Ligam P, Smythe GA, Wallace EM, Phillips D, Guilemin GJ, et al., 'Identification of kynurenine pathway enzyme mRNAs and metabolites in human placenta: Up-regulation by inflammatory stimuli and with clinical infection', American Journal of Obstetrics and Gynecology, 192 280-288 (2005) [C1]
2004Yan EB, Nichols T, Hirst J, Walker DW, 'Cerebrovascular Responses in the Fetal Sheep Brain to Low-Dose Endotoxin', Pediatric Research, 55 855-863 (2004) [C1]
2004Palliser HK, Dellios N, Escalona R, Ooi G, Rice GE, Hirst J, Young IR, 'Changes in the Expression of prostaglandin E and F synthases at induced and spontaneous labour onset in the sheep', Journal of Endocrinology, 180 469-477 (2004) [C1]
2004Nguyen PN, Young IR, Walker DW, Hirst J, 'Allopregnanolone in the brain and blood after disruption of the hypothalamic-pituitary-adrenal axis in fetal sheep', Journal of Endocrinology, 182 81-88 (2004) [C1]
2004Nguyen PN, Yan EB, Castillo-Melendez M, Walker DW, Hirst J, 'Increased allopregnanolone levels in the fetal sheep brain following umbilical cord occlusion', The Journal of Physiology, 560 593-602 (2004) [C1]
2003Nguyen PN, Billiards SS, Walker DW, Hirst J, 'Changes in 5[alpha]-pregnane steroids and neurosteroidogenic enzyme expression in the perinatal sheep', Pediatric Research, 53 956-964 (2003) [C1]
2003Crossley KJ, Nitsos I, Walker DW, Lawrence AJ, Beart PM, Hirst J, 'Steroid-sensitive GABAA receptors in the fetal sheep brain', Neuropharmacology, 45 461-472 (2003) [C1]
2003Olson DM, Zaragoza DB, Shallow MC, Cook JL, Mitchell BF, Grigsby PL, Hirst J, 'Myometrial activation and preterm labour: evidence supporting a role for the prostaglandin F receptor--a review', Placenta, 24 47-54 (2003) [C1]
2003Nguyen PN, Billiards SS, Walker DW, Hirst J, 'Changes in 5[alpha]-pregnane steroids and neurosteroidogenic enzyme expression in fetal sheep with umbilicoplacental embolisation', Pediatric Research, 54 840-847 (2003) [C1]
2003Hirst J, Scheerlinbeck JP, Phillips DJ, Jenkin G, Grigsby PL, 'Fetal responses to maternal and intra-amniotic administration of lipopolysaccharide administration in sheep', Biology of Reproduction, 68 1695-1702 (2003) [C1]
2002Haluska GJ, Wells T, Hirst J, Brenner R, Sadowsky M, Novy DW, 'Progesterone receptor localization and isoforms in myometrium, decidua and fetal membranes from rhesus monkeys: evidence for functional progesterone withdrawal at parturition.', Journal of Society for Gynaecological Investigation, 9 125-136 (2002) [C1]
2002Billiards SS, Walker DW, Canny BJ, Hirst J, 'Endotoxin Increases Sleep and Brain Allopregnanolone Concentrations in Newborn Lambs', Paediatric Research, 52 892-899 (2002) [C1]
2002Lee B, Hirst J, Walker DW, 'Inhibition of prostaglandin D synthase by intraventriculalar administration of selenium chloride induces behavioural arousal in the ovine fetus. 5679-5686 (2002) [C1]
2002Lee B, Hirst JJ, Walker DW, 'Prostaglandin D synthase in the prenatal ovine brain and effects of its inhibition with selenium chloride on fetal sleep/wake activity in utero', JOURNAL OF NEUROSCIENCE, 22 5679-5686 (2002)
2001Scott J, Grigsby P, Hirst J, Jenkin G, 'Inhibition of prostaglandin release and its effect on uterine activity during induced premature labour in late pregnant sheep. 266-276 (2001) [C1]
2001Nicol MB, Walker DW, Hirst J, 'Effect of the 5a-reductase, finasteride, on fetal behavioural state.', Neuroscience Letters, 306 13-16 (2001) [C1]
2001Scott JE, Grigsby PL, Hirst JJ, Jenkin G, 'Inhibition of prostaglandin synthesis and its effect on uterine activity during established premature labor in sheep', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 8 266-276 (2001)
2001Nicol MB, Hirst JJ, Walker DW, 'Effect of finasteride on behavioural arousal and somatosensory evoked potentials in fetal sheep', NEUROSCIENCE LETTERS, 306 13-16 (2001)
2000Crossley KJ, Walker DW, Beart PM, Hirst JJ, 'Characterisation of GABA(A) receptors in fetal, neonatal and adult ovine brain: region and age related changes and the effects of allopregnanolone', NEUROPHARMACOLOGY, 39 1514-1522 (2000)
2000Petratos S, Hirst JJ, Mendis S, Anikijenko P, Walker DW, 'Localization of P450scc and 5 alpha-reductase type-2 in the cerebellum of fetal and newborn sheep', DEVELOPMENTAL BRAIN RESEARCH, 123 81-86 (2000)
2000Grigsby PL, Poore KR, Hirst JJ, Jenkin G, 'Inhibition of premature labor in sheep by a combined treatment of nimesulide, a prostaglandin synthase type 2 inhibitor, and atosiban, an oxytocin receptor antagonist', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 183 649-657 (2000)
2000Walker DW, Lee B, Hirst J, 'Inhibition of prostaglandin D synthase in fetal sheep brain with selenium chloride induces arousal.', FASEB JOURNAL, 14 A388-A388 (2000)
2000Hirst JJ, Petratos S, Mendis S, Walker DW, 'Neuroactive steroid synthesis in the ovine fetal and newborn brain', FASEB JOURNAL, 14 A654-A654 (2000)
2000Hirst JJ, Egodagamage KC, Walker DW, 'Effect of a neuroactive steroid infused into the cerebral ventricles of fetal sheep in utero using small infusion volumes', JOURNAL OF NEUROSCIENCE METHODS, 97 37-44 (2000)
1999Nicol MB, Hirst JJ, Walker D, 'Effects of pregnanolone on behavioural parameters and the responses to GABA(A) receptor antagonists in the late gestation fetal sheep', NEUROPHARMACOLOGY, 38 49-63 (1999)
1999Poore KR, Young IR, Hirst JJ, 'Efficacy of the selective prostaglandin synthase type 2 inhibitor nimesulide in blocking basal prostaglandin production and delaying glucocorticoid-induced premature labor in sheep', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 180 1244-1253 (1999)
1998Hirst JJ, Mijovic JE, Zakar T, Olson DM, 'Prostaglandin endoperoxide H synthase-1 and -2 mRNA levels and enzyme activity in human decidua at term labor', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, 5 13-20 (1998)
1998Nicol MB, Hirst JJ, Walker DW, 'Effect of pregnane steroids on electrocortical activity and somatosensory evoked potentials in fetal sheep', NEUROSCIENCE LETTERS, 253 111-114 (1998)
1997Crossley KJ, Nicol MB, Hirst JJ, Walker DW, Thorburn GD, 'Suppression of arousal by progesterone in fetal sheep', REPRODUCTION FERTILITY AND DEVELOPMENT, 9 767-773 (1997)
1997Nicol MB, Hirst JJ, Walker D, Thorburn GD, 'Effect of alteration of maternal plasma progesterone concentrations on fetal behavioural state during late gestation', JOURNAL OF ENDOCRINOLOGY, 152 379-386 (1997)
1996Zakar T, Olson DM, Teixeira FJ, Hirst JJ, 'Regulation of prostaglandin endoperoxide H2 synthase in term human gestational tissues.', Acta physiologica Hungarica, 84 109-118 (1996)
1995HIRST JJ, TEIXEIRA FJ, ZAKAR T, OLSON DM, 'PROSTAGLANDIN ENDOPEROXIDE-H SYNTHASE-1 AND SYNTHASE-2 MESSENGER-RIBONUCLEIC-ACID LEVELS IN HUMAN AMNION WITH SPONTANEOUS LABOR ONSET', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 80 517-523 (1995)
1995ZAKAR T, HIRST JJ, MIJOVIC JE, OLSON DM, 'GLUCOCORTICOIDS STIMULATE THE EXPRESSION OF PROSTAGLANDIN ENDOPEROXIDE-H SYNTHASE-2 IN AMNION CELLS', ENDOCRINOLOGY, 136 1610-1619 (1995)
1994ZAKAR T, TEIXEIRA FJ, HIRST JJ, GUO F, MACLEOD EA, OLSON DM, 'REGULATION OF PROSTAGLANDIN ENDOPEROXIDE-H SYNTHASE BY GLUCOCORTICOIDS AND ACTIVATORS OF PROTEIN-KINASE-C IN THE HUMAN AMNION', JOURNAL OF REPRODUCTION AND FERTILITY, 100 43-50 (1994)
1994TEIXEIRA FJ, ZAKAR T, HIRST JJ, GUO F, SADOWSKY DW, MACHIN G, et al., 'PROSTAGLANDIN ENDOPEROXIDE-H SYNTHASE (PGHS) ACTIVITY AND IMMUNOREACTIVE PGHS-1 AND PGHS-2 LEVELS IN HUMAN AMNION THROUGHOUT GESTATION, AT TERM, AND DURING LABOR', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 78 1396-1402 (1994)
1993HIRST JJ, CHIBBAR R, MITCHELL BF, 'ROLE OF OXYTOCIN IN THE REGULATION OF UTERINE ACTIVITY DURING PREGNANCY AND IN THE INITIATION OF LABOR', SEMINARS IN REPRODUCTIVE ENDOCRINOLOGY, 11 219-233 (1993)
1993SLAYDEN OD, HIRST JJ, BRENNER RM, 'ESTROGEN ACTION IN THE REPRODUCTIVE-TRACT OF RHESUS-MONKEYS DURING ANTIPROGESTIN TREATMENT', ENDOCRINOLOGY, 132 1845-1856 (1993)
1993HIRST JJ, HALUSKA GJ, COOK MJ, NOVY MJ, 'PLASMA OXYTOCIN AND NOCTURNAL UTERINE ACTIVITY - MATERNAL BUT NOT FETAL CONCENTRATIONS INCREASE PROGRESSIVELY DURING LATE PREGNANCY AND DELIVERY IN RHESUS-MONKEYS', AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY, 169 415-422 (1993)
1992HIRST JJ, WEST NB, BRENNER RM, NOVY MJ, 'STEROID-HORMONE RECEPTORS IN THE ADRENAL-GLANDS OF FETAL AND ADULT RHESUS-MONKEYS', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 75 308-314 (1992)
1991HIRST JJ, HALUSKA GJ, COOK MJ, HESS DL, NOVY MJ, 'COMPARISON OF PLASMA OXYTOCIN AND CATECHOLAMINE CONCENTRATIONS WITH UTERINE ACTIVITY IN PREGNANT RHESUS-MONKEYS', JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 73 804-810 (1991)
1990HIRST JJ, RICE GE, JENKIN G, THORBURN GD, 'REGULATION OF OXYTOCIN SECRETION BY THE OVINE CORPUS-LUTEUM - EFFECT OF ACTIVATORS OF PROTEIN KINASE-C', JOURNAL OF ENDOCRINOLOGY, 124 225-232 (1990)
1988HIRST JJ, RICE GE, JENKIN G, THORBURN GD, 'CONTROL OF OXYTOCIN SECRETION BY OVINE CORPORA-LUTEA - EFFECTS OF ARACHIDONIC-ACID, PHOSPHOLIPASES, AND PROSTAGLANDINS', ENDOCRINOLOGY, 122 774-781 (1988)
1986HIRST JJ, RICE GE, JENKIN G, THORBURN GD, 'SECRETION OF OXYTOCIN AND PROGESTERONE BY OVINE CORPORA-LUTEA INVITRO', BIOLOGY OF REPRODUCTION, 35 1106-1114 (1986)
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Conference (75 outputs)

YearCitationAltmetricsLink
2012Bennett GA, Palliser HK, Kelleher MA, Saxby BM, Walker DW, Hirst JJ, 'Prenatal maternal psychosomatic stress: Effects on fetal brain development following maternal neurosteroid treatment in guinea pigs', Proceedings of the 39th Annual Meeting of the Fetal and Neonatal Physiological Society, Zeist, The Netherlands (2012) [E3]

Co-authors: Hannah Palliser

2012Zakar T, Hirst JJ, Welsh TN, 'The guinea pig model of human parturition', Proceedings of the 39th Annual Meeting of the Fetal and Neonatal Physiological Society, Zeist, The Netherlands (2012) [E3]
2012Palliser HK, Kelleher MA, Saxby B, Walker DW, Hirst JJ, Bennett GA, 'Prenatal stress and effect of maternal neurosteroid treatment on fetal brain development in guinea pigs', Journal of Paediatrics and Child Health, Sydney, Australia (2012) [E3]

Co-authors: Hannah Palliser

2012Welsh TN, Paul JW, Palliser HK, Hirst JJ, Mesiano S, Zakar T, 'PGDH expression decreases at term before labor onset in guinea pig fetal membranes', Reproductive Sciences, San Diego, CA (2012) [E3]

Co-authors: Hannah Palliser

2012Welsh TN, Caritis S, Hirst JJ, Mesiano S, Zakar T, 'Progesterone withdrawal in the pregnant guinea pig is mediated by decreased uterine PR expression and stimulated by prostaglandins in vivo', Reproductive Sciences, San Diego, CA (2012) [E3]
2012Mitchell CM, Chai S, Madsen GM, Hirst JJ, Zakar T, 'Bivalent epigenetic modifications regulate PTGS2 expression during gestation in the amnion', Reproductive Sciences, San Diego, CA (2012) [E3]

Co-authors: Gemma Madsen

2012Palliser HK, Hirst JJ, 'Vulnerability of compromised pregnancies to preterm labour', Journal of Paediatrics and Child Health, Sydney, Australia (2012) [E3]

Co-authors: Hannah Palliser

2011Palliser HK, Welsh TN, Zakar T, Symonds IM, Hirst JJ, 'Intrauterine growth restriction leads to increased prostaglandin synthesis and reduced metabolism contributing to preterm labour in the guinea pig', Journal of Paediatrics and Child Health, Hobart, Tasmania (2011) [E3]
2011Palliser HK, Welsh TN, Zakar T, Symonds IM, Hirst JJ, 'Changes to the balance of prostaglandin synthesis and metabolism with intrauterine growth restriction contributes to preterm labour in the guinea pig', Reproductive Sciences, Miami Beach, Florida (2011) [E3]
2011Mitchell CM, Sykes SD, Pringle KG, Lumbers ER, Hirst JJ, Bisits AJ, Zakar T, 'Methylation of CpG Islands in the promoters of proinflammatory and steroid receptor genes in the human amnion, decidua and placenta', Reproductive Sciences, Miami Beach, Florida (2011) [E3]

Co-authors: Kirsty Pringle

2011Kelleher MA, Hirst JJ, Palliser HK, 'A guinea pig model for the study of neuroactive steroid replacement in the preterm neonatal brain', Reproductive Sciences, Miami Beach, Florida (2011) [E3]

Co-authors: Hannah Palliser

2010Dyson RM, Palliser HK, Kelleher MA, Hirst JJ, Wright IM, 'Preterm birth and intrauterine growth restriction: effect of microvascular function in the neonatal guinea pig', The Endocrine Society of Australia Annual Scientific Meeting Proceedings and Abstract Book, Sydney (2010) [E3]
2010Kelleher MA, Palliser HK, Hirst JJ, 'Premature birth results in ex utero brain development in a low neuroprotective steroid environment', The Endocrine Society of Australia Annual Scientific Meeting Proceedings and Abstract Book, Sydney (2010) [E3]

Co-authors: Hannah Palliser

2010Kelleher MA, Palliser HK, Hirst JJ, 'Compromised neurosteroid biosynthesis in the preterm neonate', Journal of Paediatrics and Child Health: Abstracts of the 14th Annual Congress of the Perinatal Society of Australia and New Zealand 2010, Wellington, NZ (2010) [E3]

Co-authors: Hannah Palliser

2010Marques FZ, Pringle KG, Markus MA, Conquest AL, Hirst JJ, Sarris M, et al., 'Molecular characterization of renin-angiotensin system components in human intrauterine tissues and fetal membranes from vaginal delivery and cesarean section', Reproduction, Fertility and Development, Sydney (2010) [E3]
2010Pringle KG, Zakar T, Hirst JJ, Lumbers ER, 'Evidence that the renin angiotensin system is involved in early placentation', Journal of Paediatrics and Child Health: Abstracts of the 14th Annual Congress of the Perinatal Society of Australia and New Zealand 2010, Wellington, NZ (2010) [E3]

Co-authors: Kirsty Pringle

2010Dyson RM, Kelleher MA, Palliser HK, Hirst JJ, Wright IM, 'The guinea pig as an animal model for studying microvascular function in the preterm neonate in early extrauterine life', 9th World Congress for Microcirculation. Final Program and Abstract Book, Paris, France (2010) [E3]
2010Lumbers ER, Pringle KG, Marques FZ, Hirst JJ, Markus MA, Morris BJ, et al., 'Identification of renin-angiotensin system (RAS) in human fetal membranes, decidua and placenta and the effects of gender and labour', Hypertension, Dallas, TX (2010) [E3]

Co-authors: Kirsty Pringle

2010Welsh TN, Mesiano S, Hirst JJ, Zakar T, 'Decreased uterine progesterone receptor expression may explain functional progesterone withdrawal in the pregnant guinea pig', The Endocrine Society of Australia Annual Scientific Meeting Proceedings and Abstract Book, Sydney (2010) [E3]
2009Pringle KG, Hirst JJ, Conquest AL, Mitchell CM, Zakar T, Lumbers ER, 'The role of prorenin in amnion PGHS-2 expression and the induction of labour', Journal of Paediatrics and Child Health, Darwin, NT (2009) [E3]
2009Lumbers ER, Pringle KG, Roach DM, Mitchell CM, Hirst JJ, Markus A, et al., 'The identification and role of the intrauterine (Pro)renin/(Pro)renin receptor angiotensin system in prostaglandin synthesis in pregnancy', Reproductive Sciences, Glasgow, Scotland (2009) [E3]

Co-authors: Kirsty Pringle

2009Pringle KG, Hirst JJ, Mitchell CM, Zakar T, Lumbers ER, 'The mechanism of prorenin induced PGHS-2 expression in the amnion', Reproductive Sciences, Glasgow, Scotland (2009) [E3]

Co-authors: Kirsty Pringle

2009McKendry AA, Palliser HK, Walker DW, Hirst JJ, 'Effect of betamethasone treatment on steroidogenic enzyme expression in growth restricted fetal guinea pigs', Journal of Paediatrics and Child Health, Darwin, NT (2009) [E3]
2009Roach DM, Hirst JJ, Palliser HK, 'Effect of IUGR and sex on PR expression in the fetal guinea pig brain', Journal of Paediatrics and Child Health, Darwin, NT (2009) [E3]
2009Kelleher MA, Palliser HK, Walker DW, Hirst JJ, 'Effect of intrauterine growth restriction and pharmacologic inhibition of 5alpha-reductase on enzyme expression in the fetal cerebellum', Journal of Paediatrics and Child Health, Darwin, NT (2009) [E3]
2009Palliser HK, Zakar T, Hirst JJ, 'Effect of growth restriction on myometrial progesterone receptor expression near term', Journal of Paediatrics and Child Health, Darwin, NT (2009) [E3]
2009McKendry AA, Palliser HK, Walker DW, Hirst JJ, 'The effect of betamethasone treatment on peripheral eurosteroidogenesis in a guinea pig model of growth restriction', Reproductive Sciences, Glasgow, Scotland (2009) [E3]

Co-authors: Hannah Palliser

2009Gibson KJ, Wang Y, Boyce AC, Palliser HK, Hirst JJ, Lumbers ER, 'Effects of intrauterine growth restriction on the intrarenal renin angiotensin system in the neonatal guinea pig', Journal of Paediatrics and Child Health, Darwin, NT (2009) [E3]
2008Zakar T, Hirst JJ, Mitchell CM, 'Glucocorticoid regulation of prostaglandin synthesis in the human fetal membranes: Duality in the style of Dr. Jekyll and Mr. Hyde?', The Twenty-Second Fetal and Neonatal Workshop of Australia and New Zealand Abstract Book, Runaway Bay, QLD (2008) [E3]
2008Sullivan RK, Palliser HK, McKendry AA, Roach DM, Walker DW, Hirst JJ, 'Effect of betemethasone treatment on apoptotic cell death and neurosteriodogenic pathways in a guinea pig model of growth restriction', 2008 Neuroscience Meeting Planner, Washington, DC (2008) [E3]

Co-authors: Hannah Palliser

2008Kelleher MA, Palliser HK, Roach DM, Sullivan RK, Walker DW, Hirst JJ, 'Effect of 5 alpha-reductase inhibition on apoptotic brain cell death and the expression of neurosteroidogenic enzymes in the fetal and neonatal guinea pig', Journal of Paediatrics and Child Health, Gold Coast, QLD (2008) [E3]
2008McKendry AA, Palliser HK, Roach DM, Sullivan RK, Walker DW, Hirst JJ, 'Repeated exposure to betamethasone increases brain cell death and suppresses neurosteroidogenic pathways in the growth restricted guinea pig fetus', Journal of Paediatrics and Child Health, Gold Coast, QLD (2008) [E3]
2008Roach DM, Lumbers ER, Mitchell CM, Hirst JJ, Zakar T, 'The identification of the intrauterine (pro)renin/(pro)renin receptor system and its role in prostaglandin synthesis in pregnancy and labour', Journal of Paediatrics and Child Health, Gold Coast, QLD (2008) [E3]
2008Mitchell CM, Hubbard SA, Hirst JJ, Giles WB, Zakar T, 'Chronic suppression of prostaglandin endoperoxide H synthase (PGHS-2) expression in the human amnion by glucocorticoids in vivo', 51st Annual Scientific Meeting of the Endocrine Society of Australia and Society of Reproductive Biology: Meeting Proceedings and Abstract Book, 51st Annual Scientific Meeting of the Endocrine So (2008) [E3]
2008Smith AT, Palliser HK, Zakar T, Dunstan RH, Hirst JJ, 'Neurosteroid profiles in fetal, maternal and neonatal guinea pigs using gas chromatography-mass spectrometry', The Twenty-Second Fetal and Neonatal Workshop of Australia and New Zealand Abstract Book, Runaway Bay, QLD (2008) [E3]
2008Lumbers ER, Roach DM, Mitchell CM, Hirst JJ, Zakar T, 'The identification and role of the intrauterine (pro) renin/(pro)renin receptor system in prostaglandin synthesis in pregnancy', Reproductive Sciences, San Diego, CA (2008) [E3]
2008Kelleher MA, Palliser HK, Roach DM, Sullivan RK, Walker DW, Hirst JJ, 'Effect of inhibition of 5 alpha reduced steroid synthesis on apoptotic brain cell death and neurosteroidogenic enzyme expression in the fetal and neonatal guinea pig', Reproductive Sciences, San Diego, CA (2008) [E3]

Co-authors: Hannah Palliser

2008Pringle KG, Roach DM, Mitchell CM, Hirst JJ, Zakar T, Lumbers ER, 'The intrauterine (pro)renin/(pro)renin receptor system and its role in prostaglandin synthesis during pregnancy', 51st Annual Scientific Meeting of the Endocrine Society of Australia and Society of Reproductive Biology: Meeting Proceedings and Abstract Book, Melbourne, VIC (2008) [E3]

Co-authors: Kirsty Pringle

2008McKendry AA, Palliser HK, Roach DM, Sullivan RK, Walker DW, Hirst JJ, 'Effect of betamethasone treatment on brain cell death and neurosteroidogenic pathways in a guinea pig model of growth restriction', Reproductive Sciences, San Diego, CA (2008) [E3]

Co-authors: Hannah Palliser

2007Roach DM, Palliser HK, Walker DW, Hirst JJ, 'Expression of 5aReductase enzymes in uterine tissues at term and following labor', Reproductive Sciences (Scientific Program & Abstracts: 54th Annual Meeting, SGI), Reno, Nevada (2007) [E3]

Co-authors: Hannah Palliser

2007Yawno T, Castillo-Melendez M, Walker D, Hirst JJ, 'Neuroprotective role for allopregnanolone on cerebellar purkinje cells in fetal sheep (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
2007Smith AT, Palliser HK, Hirst JJ, 'Measurement of neurosteroids in the fetal and neonatal guinea pig brain using gas chromatography-mass spectrometry', Fetal & Neonatal Workshop of Australia and New Zealand 21st Annual Meeting. Abstracts, Melbourne, VIC (2007) [E3]

Co-authors: Hannah Palliser

2007Palliser HK, Roach DM, Walker DW, Hirst JJ, 'Expression of 5aReductase enzymes in the fetal guinea pig brain and placenta following intrauterine growth restriction', Reproductive Sciences (Scientific Program & Abstracts: 54th Annual Meeting, SGI), Reno, Nevada (2007) [E3]

Co-authors: Hannah Palliser

2007Palliser HK, Roach DM, Walker DW, Hirst JJ, 'Effect of intrauterine growth restriction on the expression of 5alpha reductase in the fetal guinea pig brain and placenta', Satellite Conference of DOHaD 2007 (5th World Congress of Developmental Origins of Health and Disease), Melbourne, VIC (2007) [E3]

Co-authors: Hannah Palliser

2006Yawno T, Yan EB, Walker DW, Hirst JJ, 'Inhibition of neurosteroid synthesis increases asphyxia-induced brain injury in the late gestation fetal sheep', Journal of the Society for Gynecologic Investigation (Vol. 13, no. 2: 31) Scientific Program and Abstracts 53rd Annual Meeting - March 22-25, 2006 Toronto, Ontario, Toronto, Canada (2006) [E3]
2006Hirst JJ, Westcott KT, Ciurej I, Walker DW, Wlodek ME, 'Neurosteroids in the brain of growth restricted fetal and newborn rats (Poster presentation)', Journal of the Society for Gynecologic Investigation (Vol. 13, no. 2: 729) Scientific Program and Abstracts 53rd Annual Meeting - March 22-25, 2006 Toronto, Ontario, Toronto, Ontario (2006) [E3]
2006Saglam B, Yan EB, Hirst JJ, Walker DW, 'Maternal infusion of the COX-2 inhibitor, nimesulide, suppresses normal and asphyxia-induced apoptotic cell death in the fetal hippocampus (Poster presentation)', Journal of the Society for Gynecologic Investigation (Vol. 13, no. 2: 729) Scientific Program and Abstracts 53rd Annual Meeting - March 22-25, 2006 Toronto, Ontario, Toronto, Ontario (2006) [E3]
2006Hirst JJ, Westcott KT, Ciurej I, Walker DW, Wlodek ME, 'Neurosteroids in the brain of growth restricted fetal and newborn rats.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Toronto, CANADA (2006)
2005Palliser HK, Hirst JJ, Rice GE, Dellios NL, Escalona RM, Ooi GT, Young IR, 'The NF kappa B inhibitor, sulfasalazine, suppresses uterine activity by a PGHS- independent pathway.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Los Angeles, CA (2005)
2004Palliser HK, Hirst JJ, Rice GE, Dellios NL, Escalona RM, Ooi GT, Young IR, 'Expression of prostaglandin E and F receptors in ovine gestational tissues at labour onset', Perinatal Society of Australia and New Zealand 7th Annual Meeting, Not Known (2004) [E3]

Co-authors: Hannah Palliser

2004Palliser HK, Dellios N, Escalona R, Ooi G, Rice GE, Hirst JJ, '2004 Prostaglandin F and E synthases in ovine myometrium, endometrium and placenta during at labour onset', Society for Gynecologic Investigation 51st Annual Meeting, Not Known (2004) [E3]

Co-authors: Hannah Palliser

2004Hirst JJ, Young IR, Palliser HK, Peri KG, Zaragoza DB, Olson DM, '2004 delay of preterm birth in sheep by THG-113, a prostaglandin F2a receptor antagonist: electromyographic activity, blood gases and PGs', Society for Gynecologic investigation 51st annual meeting, Not Known (2004) [E3]

Co-authors: Hannah Palliser

2004Parkington HC, Hirst JJ, Young IR, Palliser HK, Palliser DM, 'THG-113, a prostaglandin F2a (PGF2a) receptor antagonist suppresses the sensitivity to maximal contractile activity evoked by exogenous PGF2a in isolated sheep myometrium', Society for Gynecologic Investigation 51st Annual Meeting, Not Known (2004) [E3]

Co-authors: Hannah Palliser

2004Palliser HK, Dellios N, Escalona R, Rice GE, Hirst JJ, Young IR, '2004 Changes in prostaglandin receptor expression in the amnion and cervix following preterm and term labour', Endocrine Society of Australian 47th Annual Meeting, Not Known (2004) [E3]

Co-authors: Hannah Palliser

2004Palliser HK, Hirst JJ, Rice GE, Dellios NL, Escalona RM, Ooi GT, Young IR, 'Increase in the expression of prostaglandin F synthase in ovine gestational tissues at labor onset.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Houston, TX (2004)
2004Hirst JJ, Young IR, Palliser HK, Peri KG, Zaragoza DB, Olson DM, 'Delay of preterm birth in sheep by THG113.31, a prostaglandin (PG)F-2 alpha receptor (FP) antagonist: Electromyographic activity (EMG), blood gases, and PGs.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Houston, TX (2004)
2003Palliser HK, Dellios N, Escalona R, Ooi G, Rice GE, Hirst JJ, Young IR, 'Prostaglandin synthetic enzymes in the ovine myometrium, endometrium and placenta during induced-preterm and spontaneous' (2003) [E1]
2003Nguyen PN, Young IR, Walker DW, Hirst JJ, 'Neurosteroids in the brain of fetal sheep after hypophysectomy or adrenalectomy' (2003) [E3]
2003Scott KM, Cassaglia P, Nguyen PN, Walker DW, Hirst JJ, 'Excitatory neurosteroids in the fetal and newborn brain: ontogenic changes and effects of chronic intrauterine hypoxaemia' (2003) [E3]
2003Renda A, Pallister H, Hirst JJ, Young IR, Kemp B, Hoffman P, Rice GE, 'Identification of novel labour-associated proteins in cervico-vaginal fluid' (2003) [E3]
2003Olson DM, Grisby PL, Peri K, Hirst JJ, 'A specific antagonist of the prostaglandin (PG) F2a receptor, THG113.31a, delays preterm labour induced by RU486 in sheep' (2003) [E3]
2003Billiards SS, Wilkinson VE, Walker DW, Canny BJ, Hirst JJ, 'Deoxyxorticosterone: its role in the stress response in newborn lambs', Proceedings of the 6th Annual Meeting, Perinatal Society of Australia and New Zealand, Christchurch New Zealand (2003) [E3]
2003Nguyen PN, Yan EB, Scott KM, Castillo-Melendez M, Walker DW, Hirst JJ, 'Umbilical cord occlusion althers 5a-pregnane steroid content in the brain, adrenal and plasma of ovine fetuses' (2003) [E3]
2003Nguyen PN, Young IR, Walker DW, Hirst JJ, 'P450scc/5a-reductase expression and neurosteroid content in the brain after hypophysectomy or adrenalectomy' (2003) [E3]
2003Nguyen PN, Billards SS, Walker DW, Hirst JJ, 'Changes in allopregnanolone concentrations and neurosteroidogenic enzyme expression in the IUGR fetus' (2003) [E3]
2003Nguyen PN, Walker DW, Castillo-Melendez M, Hirst JJ, 'Changes in allopregnanolone concentrations and neurosteroidogenic enzyme expression in the compromised fetus' (2003) [E3]
2003Nguyen PN, Young IR, Walker DW, Hirst JJ, 'Increased allopregnanolone concentrations in the fetal brain following umbilical cord occlusion' (2003) [E3]
2002Nguyen PN, Walker DW, Hirst JJ, 'Hypoxia alters neuroactive steroid production in the fetal brain' (2002) [E3]
2002Nguyen PN, Billiards SS, Hirst JJ, Walker DW, '5 -reductase expression and allopregnanolone concentrations in the fetal an neonatal brain' (2002) [E3]
2001Gigsby PL, Hirst JJ, Phillips DJ, Scheerlink JP, Jenkin G, 'Responses to intra-amniotic administration of endotoxin in late gestation sheep' (2001) [E3]
2001Billiards SS, Walker DW, Canny BJ, Hirst JJ, 'Neuroactive steroid and behavioural responses to endotoxin treatment in newborn lambs' (2001) [E3]
2001Billards SS, Walker DW, Hirst JJ, 'Effect of endotoxin treatment on sleep and arousal in newborn lambs: a link between infection and SIDS' (2001) [E3]
1995HIRST JJ, TEIXEIRA FJ, ZAKAR T, OLSON DM, 'PROSTAGLANDIN-H SYNTHASE-2 EXPRESSION INCREASES IN HUMAN GESTATIONAL TISSUES WITH SPONTANEOUS LABOR ONSET', REPRODUCTION FERTILITY AND DEVELOPMENT, HAMILTON ISL, AUSTRALIA (1995)
1993TEIXEIRA FJ, ZAKAR T, HIRST J, GUO F, MACHIN G, OLSON DM, 'PROSTAGLANDIN ENDOPEROXIDE-H SYNTHASE (PGHS) ACTIVITY INCREASES WITH GESTATION AND LABOR IN HUMAN AMNION', JOURNAL OF LIPID MEDIATORS, MONTREAL, CANADA (1993)
1993OLSON DM, ZAKAR T, TEIXEIRA F, HIRST J, GUO F, PANKOVICH J, 'PROSTAGLANDINS AND PARTURITION', PROGRESS IN ENDOCRINOLOGY, NICE, FRANCE (1993)
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Grants and Funding

Summary

Number of grants28
Total funding$6,490,444

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2015 (2 grants)

Perinatal stress leads to neruosteroid deficits and adverse behavioural outcomes$1,151,520
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Jon Hirst, Associate Professor David Walker, Doctor Hannah Palliser, Professor Deborah Hodgson
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,151,52020152018
GNo:G1400014

Epigenetic regulation of inflammatory genes in the fetal membranes: role in term and preterm birth$452,729
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Tam Zakar, Associate Professor Jon Hirst, Professor Murray Mitchell
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$452,72920152017
GNo:G1400158

2014 (1 grants)

Progesterone therapy for preterm labour - evaluation of effects on fetal neuroactive steroid profiles$27,512
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Associate Professor Jon Hirst, Conjoint Professor Ian Symonds, Doctor Hannah Palliser
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$27,51220142014
GNo:G1400122

2013 (2 grants)

Disrupted neurosteroid synthesis mediates the adverse effects of prenatal stress$671,952
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Jon Hirst, Associate Professor David Walker, Dr Mary Tolcos
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$671,95220132015
GNo:G1200177

Steroid and the Nervous System 7th Int Meeting, Italy 16-20 March 2013.$2,000
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Associate Professor Jon Hirst
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,00020132013
GNo:G1300745

2012 (2 grants)

Disruption of gestational neurosteroid concentrations by stressful events leads to adverse neurodevelopmental and behavioural outcomes in children form these pregnancies$34,454
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Associate Professor Jon Hirst, Conjoint Professor Ian Symonds, Doctor Hannah Palliser
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$34,45420122012
GNo:G1200176

Precellys Tissue Homogeniser$10,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Roger Smith, Professor Eugenie Lumbers, Conjoint Professor Tam Zakar, Associate Professor Jon Hirst, Conjoint Professor Ian Wright, Doctor Gemma Madsen, Doctor Kaushik Maiti
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$10,00020122012
GNo:G1100979

2011 (2 grants)

Pathways of neurosteroid-mediated protection following compromised pregnancy and preterm birth$547,415
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Jon Hirst, Associate Professor David Walker, Associate Professor Helena Parkington
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$547,41520112013
GNo:G1000246

Research microscope, confocal ready nikon eclipse 90i microscope$69,157
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Roger Smith, Conjoint Professor Tam Zakar, Associate Professor Jon Hirst, Doctor Kaushik Maiti, Doctor Gemma Madsen, Professor Rodney Scott, Conjoint Professor Peter Wark, Professor Paul Foster, Professor Phil Hansbro, Conjoint Professor Ian Wright
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$69,15720112011
GNo:G1100024

2010 (1 grants)

Investigation of IUGR-associated preterm labour using a guinea pig model$23,025
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Doctor Hannah Palliser, Associate Professor Jon Hirst, Conjoint Professor Ian Symonds
SchemeRole
Research GrantInvestigator
Total AmountFunding StartFunding Finish
$23,02520102010
GNo:G1000119

2009 (3 grants)

Mechanisms of escape from progesterone-induced suppression: Role in normal and preterm birth$526,500
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Tam Zakar, Associate Professor Jon Hirst
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$526,50020092011
GNo:G0188872

Leica VT1200S - Fully automated vibrating blade microtome$16,209
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Robert Callister, Associate Professor Alan Brichta, Conjoint Professor Keith Jones, Associate Professor Jon Hirst, Doctor Brett Graham, Associate Professor Philip Bolton, Doctor Phil Jobling, Associate Professor Paul Tooney, Doctor Angela McPherson, Doctor Rebecca Lim, Doctor Ramatis De Oliveira, Mr Matthew Walsh
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$16,20920092009
GNo:G0189842

i-STAT 1 Blood Gas Analyser and Softron BP-98E$13,470
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Ian Wright, Associate Professor Jon Hirst, Professor Eugenie Lumbers, Conjoint Professor Tam Zakar, Doctor Hannah Palliser
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$13,47020092009
GNo:G0189843

2008 (3 grants)

The role of the intrauterine (pro) renin/(pro)renin receptor system in prostaglandin synthesis in pregnancy$468,750
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Eugenie Lumbers, Conjoint Professor Tam Zakar, Associate Professor Jon Hirst, Professor Brian Morris
SchemeRole
Project GrantInvestigator
Total AmountFunding StartFunding Finish
$468,75020082010
GNo:G0187618

Does fetal growth restriction increase uterine activity and upregulate labour associated genes preterm?$15,208
Funding Body: John Hunter Hospital Charitable Trust Fund

Project Team
Associate Professor Jon Hirst, Doctor Hannah Palliser, Conjoint Professor Ian Symonds
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$15,20820082008
GNo:G0189368

LED fluorescence illuminators and filter set (525nm + 575DF20) for LAS3000 image analysis system$9,600
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Roger Smith, Conjoint Professor Ian Symonds, Conjoint Associate Professor Andrew Bisits, Conjoint Professor Tam Zakar, Doctor John Fitter, Doctor Cheng Chan, Conjoint Associate Professor Rick Nicholson, Doctor Giavanna Angeli, Doctor Kaushik Maiti, Doctor Jonathan Paul, Associate Professor Jon Hirst, Doctor Hannah Palliser, Professor Eugenie Lumbers
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$9,60020082008
GNo:G0188543

2007 (5 grants)

Neurosteroid mediated protection after birth: approaches for maximising protective steroid levels in the neonatal brain$433,625
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Jon Hirst, Associate Professor David Walker
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$433,62520072009
GNo:G0186424

Beta Radiation Counter Instrument facility$25,670
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Roger Smith, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Tam Zakar, Conjoint Associate Professor Rick Nicholson, Dr Mark Read, Doctor Cheng Chan, Doctor John Fitter, Conjoint Associate Professor Andrew Bisits, Associate Professor Jon Hirst, Doctor Hannah Palliser, Conjoint Professor Ian Symonds
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$25,67020072007
GNo:G0188194

The hormonal regulation of birth$20,000
Funding Body: University of Newcastle

Project Team
Conjoint Professor Tam Zakar, Associate Professor Jon Hirst
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020072007
GNo:G0187183

Prostaglandin Transporters Controlling Prostaglandin Metabolism in the pregnant Uterus$7,166
Funding Body: University of Newcastle

Project Team
Conjoint Professor Tam Zakar, Associate Professor Jon Hirst
SchemeRole
Pilot GrantInvestigator
Total AmountFunding StartFunding Finish
$7,16620072007
GNo:G0187886

4th IntMeeting on Steroids and the Nervous System, 17-21 February 2007$1,700
Funding Body: University of Newcastle

Project Team
Associate Professor Jon Hirst
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,70020072007
GNo:G0187374

2006 (3 grants)

PRC - Priority Research Centre for Reproductive Science$544,282
Funding Body: University of Newcastle

Project Team
Laureate Professor John Aitken, Professor Roger Smith, Professor Eileen McLaughlin, Associate Professor Brett Nixon, Doctor Shaun Roman, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Warwick Giles, Associate Professor Jon Hirst, Conjoint Associate Professor Rick Nicholson, Conjoint Professor Ian Symonds
SchemeRole
Priority Research CentreInvestigator
Total AmountFunding StartFunding Finish
$544,28220062013
GNo:G0186945

Neurosteroids in the neonatal brain: potential role in protecting against perinatal brain injury$16,000
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Jon Hirst, Conjoint Associate Professor Vicki Clifton
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$16,00020062006
GNo:G0186100

Strategies for maintaining neurosteroid-mediate brain protection following compromised pregnancies.$15,000
Funding Body: University of Newcastle

Project Team
Associate Professor Jon Hirst
SchemeRole
New Staff GrantChief Investigator
Total AmountFunding StartFunding Finish
$15,00020062006
GNo:G0186743

2005 (2 grants)

Contribution of disturbed blood flow and cerebral metabolism in white matter injury in the perinatal brain $366,000
Funding Body: National Health & Medical Research Council

SchemeRole
Investigator
Total AmountFunding StartFunding Finish
$366,00020052007
GNo:17126159

Neuroactive Steroids in the developing brain: potential for preventing perinatal brain damage$316,500
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Jon Hirst
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$316,50020052006
GNo:G0185607

2002 (1 grants)

Mechanisms controlling prostaglandin synthesis and myometrial activation at labour onset$285,000
Funding Body: National Health & Medical Research Council

SchemeRole
Investigator
Total AmountFunding StartFunding Finish
$285,00020022004
GNo:17126084

2001 (1 grants)

Essential protective role of neuroactive steroids in the fetal and neonatal brain $420,000
Funding Body: National Health & Medical Research Council

SchemeRole
Chief Investigator
Total AmountFunding StartFunding Finish
$420,00020012003
GNo:17126090
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Research Supervision

Number of current supervisions8
Total current UoN PhD EFTSL1.85

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20142018PhD(Experimental Pharmacology)Principal SupervisorNovel Mechanisms Linking Stressful Events in Pregnancy and Behavioural Disorders in Childhood
20132017PhD(Experimental Pharmacology)Principal SupervisorAffect of Prenatal Insults on Long-Term Behaviour and Neurodevelopment; and Potential Neurosteroid Replacement Therapy
20122016PhD(Experimental Pharmacology)Principal SupervisorThe Outcomes of Offspring Exposed to Prenatal Stress: When is Enough Enough?
20102013PhD (Reproductive Medicine)Co-SupervisorEpigenetic Regulation of Prostaglandin Synthesis at Birth
20072007Honours Medical Science
University of Newcastle
Principal Supervisor5a-reductases enzymes with in the brain of compromised fetuses
20072007Honours Medical Science
University of Newcastle
Co-SupervisorEffect of glucocorticoid treatment on neurosteroid synthesis and perinatal brain injury
20072007Honours Medical Science
University of Newcastle
Co-SupervisorExpression of progesterone receptor isoforms in the guinea pig myometrium
20042007PHD Medical Science
Monash University
Co-SupervisorDevelopment of steroid based neuroprotective therapies for the fetus and neonate

Past Supervision

YearProgramSupervisor TypeResearch Title
2012PhD(Experimental Pharmacology)Principal SupervisorPotential Neurosteroid Replacement Therapy Following Premature Birth and Fetal Growth Restriction
2010M Philosophy (Exper Pharmacol)Principal SupervisorBetamethasone: A Neuroactive Steroid Deficit and Adverse Effects in the Brain?
2006Honours Medical Science
Monash University
Co-SupervisorMechanism for reducing perinatal brain injury
2006Honours Accounting
University of Newcastle
Principal SupervisorExpression of 5a-reductases in the fetal brain and placenta
2005PHD Medical Science
Monash University
Principal SupervisorRole of neurosteroids in the fetal and newborn brain
2004Honours Medical Science
Monash University
Co-SupervisorUse of NFKB agonist in the treatment of preterm labour
2004Honours Medical Science
Monash University
Co-SupervisorPregnenolone and pregnenolone sulphate in the fetal brain
2003PHD Medical Science
Monash University
Principal SupervisorNeurosteroids and somnogenic responses to endotoxin and hypoxia in lambs
2002Honours Medical Science
Monash University
Co-SupervisorRole of steroid sulphates in perinatal brain injury
2002PHD Medical Science
Monash University
Co-SupervisorDevelopment of new strategies for teh inhibition of preterm labour
2000PHD Medical Science
Monash University
Principal SupervisorSteroids and GABAA receptors in the developing brain
2000PHD Medical Science
Monash University
Principal SupervisorEffects of pregnane steroids on behavioural parameters in fetal sheep
1950PHD Medical Science
Monash University
Co-SupervisorRegulation of prostaglandin synthesis and receptors during sponanious and induced ovine labour
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Associate Professor Jonathan (Jon) Hirst

Work Phone(02) 40420360
Cell / Mobile Phone0413961638
Fax(02) 4921 7903
Email
PositionAssociate Professor
Mothers and Babies Research Centre
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaPharmacy and Experimental Pharmacology
Office
RM3407,
HMRI,
Callaghan
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/jon-hirst