Dr Arnab Ghosh

Dr. Arnab Ghosh is a Cancer Institute NSW ECR Fellow at the University of Newcastle. He completed a Bachelor by Honours in Veterinary Surgery, and Master’s by Research in Virology followed by a Ph.D. in Reproductive Biology from the University of Newcastle in 2019. In his PhD research, Dr. Ghosh identified the stem cell of fallopian tube and detailed their role in fallopian tube homeostasis and formation of pre-cancerous lesions in ovarian cancer. He published this finding in one of the most reputed journals in the field named Development in 2017. Dr. Ghosh further advanced his research journey by joining as a post-doctoral research fellow at the University of Newcastle and published another ground-breaking discovery in a high-impact journal named Cell Reports about the role of mesenchymal-epithelial transition in Fallopian Tube and Uterine epithelial homeostasis.

For women, taking control of their health and being proactive includes having early detection and getting accurate treatment for gynaecological diseases to live healthier, happier, and longer life, inspired Dr. Ghosh to pursue his current research which is focused on understanding the role of immune cells in gynaecological diseases such as, Endometriosis, Ovarian Cancer, Endometrial Cancer, Cervical Cancer etc. to develop novel diagnostics and treatments to improve women health.  To pursue his research goals, Dr. Ghosh is using his Veterinary Medicine skills to develop multiple genetically modified mouse lines and patient-derived xenograft mouse model to study gynaecological cancer progression and treatment options. He is one of the leading experts for developing a technology called “organ on a chip” (scientifically known as organoids when developed from healthy tissue and tumoroids when developed from cancer tissue). With this technique Dr. Ghosh develops mini reproductive organs from healthy or cancer tissue to mimic the exact structure and function of the organ inside the patient body. Excitingly, the tiny tumoroids developed from the cancer tissue can match the patient’s response to drug 100% of the time, which means if a drug doesn’t work in his system, and then it will not work in the patient. His recent focus is to add immune cells in these mini tumoroid structure to study the interaction between immunity and cancer cells. Moreover, his expertise also includes flowcytometry, single cell RNA sequencing, qPCR, confocal imaging, rheometer, ECM-based assays, immune-based assays, nucleic acid and protein-based assays etc.

Beside the passion for research, Dr. Ghosh is a strong advocate of women health, which is evident by his active involvement in national and international gynaecological disease research bodies, as Governance Body Member of Global Centre for Gynaecological Diseases, Newcastle, Australia and Cancer Detection and Therapy Research Program, Hunter Medical Research Institute, Newcastle, Australia. In his short career, he put himself in an exemplary category of scientists who can work on both in the laboratory and clinical sciences, which is reflected by numbers of invitations to present his work at the national and international conferences, including Stem Cell Meeting at Melbourne 2019, Society of Reproductive Biology annual meeting at Sydney and Perth in 2019 and 2017 respectively and International Centre for Genetic Engineering and Biotechnology (ICGEB) 2014, Italy. He is also actively involved in teaching the future generations of Australian scientists and currently supervising three PhD students at the University of Newcastle. The quality of his research is reflected by 41 publications in international scientific journals and the proceedings of international and national conferences that includes high-impact journals like, Development, Cell Reports, Cell Stem Cell, PNAS and Cell Reports Medicine.