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Career Summary

Biography

Within the School of Biomedical Sciences and Pharmacy I am convenor for Research Higher Degrees and the Student Academic Conduct Officer (SACO). Within the University I am coordinator for the Cardiovascular RQF at the University of Newcastle and I represent the Hunter region on the NSW Cardiovascular Research Network. Currently I serve as Chair of the cardiovascular program within the Hunter Medical Research Institute.

My research aims are shared by Mr Paul Johnson (research assistant), and three PhD students (Ms Kafa Walweel, Ms Jiao Li and Ms Devya Mehra). These aims are also shared by collaborators at several Australian Universities and internationally, with current projects involving researchers in the USA (Dr Ikemoto from Harvard School of Medicine, Dr Knollmann from Vanderbilt University and Dr Shtifman from St. Elizabeth's Medical Center in Boston) and Sweden (Dr. Birnir from Lund University).

I have been a council member and webmaster for Australian Physiological Society since 2000. I am a reviewer for many international journals (e.g. Journal of General Physiology, Biophysical Journal) and for the funding bodies (ARC, NH&MRC and Wellcome trust). I served as a member on peer review panels in Australia and internationally. I have chaired the organising committees for 2 Australian conferences (Curtin Conference 2000, Australian Physiological Society 2007). My research has attracted a number of highly prised fellowships from the ARC, including a Queen Elizabeth II Fellowship, Senior Research Fellowship and a Professorial Fellowship and also a Brawn Senior Fellowship from the University of Newcastle

Qualifications

  • PhD, University of New South Wales, 11/05/1984
  • Bachelor of Science (Honours)(Physics), University of New South Wales, 28/04/1978

Research

Research keywords

  • Membrane transport
  • cardiac muscle
  • ion channels
  • skeletal muscle

Research expertise

The theme to my research career has been the use of biophysical methods to study membrane transport and ion channel function. I use electrophysiolological techniques to measure ion channel function. Channel function is analysed using markov theory to unravel and identify the complex mechanisms that control ion channels within cells.

Fields of Research

CodeDescriptionPercentage
111599Pharmacology And Pharmaceutical Sciences Not Elsewhere Classified60
111699Medical Physiology Not Elsewhere Classified20
029900Other Physical Sciences20

Memberships

Editorial Board.

  • Editor for Clinical and Experimental Pharmacology and Physiology
  • Editor for Clinical and Experimental Pharmacology and Physiology

Learned Academy.

  • Council member 2000-2007

Appointments

ARC - Aust Professorial Fellowship (level D E)
ARC (Australia)
01/01/2006
Prestigious fellowship
Senior Research Fellow (ARC) (Australia)
01/01/1992 - 01/12/2005
Prestigious fellowship
Professorial Research Fellowship (Australia)
01/01/2001 - 01/12/2005

Invitations

Gordon Conference on Muscle
Gordon conferences, Australia (Conference Presentation - non published.)
2006
Gordon conference on excitation contraction coupling
Gordon conference, Australia (Conference Presentation - non published.)
2003
IUPS satelite confernece
IUPS, Australia (Conference Presentation - non published.)
2001
Biomembrane program,
AgResearch, Australia (External Reviewer - Programs.)
2004

Collaboration

I have had a long standing interest in how ion channels are able to be selective to specific ion species and how they can open and close in response to stimuli from within the cell and the external environment. My understanding of ion channel function is primarily built upon biophysical measurement of ion flow through single ion channels using techniques such as patch-clamp of cell membranes and fusion of ion channels with artificially produced lipid membranes.

Since 1995, I have devoted much of my attention to understanding how intracellular calcium and magnesium ions regulate the opening of calcium release channels in cardiac and skeletal muscle. These calcium release channels (called ryanodine receptors) mediate the release of calcium from internal stores within the cells which, in turn, provides the signal for muscle contraction. In the heart, these channels are important for timing of the heart beat and inherited mutations in these channels are known to lead to cardiac arrhythmia and sudden death.

I have discovered several mechanisms by which calcium release channels are regulated by intracellular Ca2+ and Mg2+ and the key differences between those found in cardiac and skeletal muscle. These discoveries have provided insight into mechanisms for cardiac contraction and rythmicity, how their mal regulation leads to cardiac arrhythmias and how pharmacological modulation of the calcium release channels can reverse cardiac arrhythmias arising from congenital heart diseases such as CPVT.

Administrative

Administrative expertise

2004-present Co- Chairman of the Cardiovascular program of the Hunter Medical Research Institute.

Teaching

Teaching keywords

  • Ion channels
  • disease
  • electrophysiology

Teaching expertise

I have lectured and coordinated small undersgraduate courses (20-50 students) in my research area. I have coordinated and run laboratory classes in physiology and physics. I have supervised post graduate and honours students in physiology and biophysics

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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2005Beard NA, Casarotto MG, Wei L, Varsanyi M, Laver DR, Dulhunty AF, 'Regulation of ryanodine receptors by calsequestrin: Effect of high luminal Ca2+ and phosphorylation', Biophysical Journal, 88 3444-3454 (2005) [C1]
2003Haarmann C, Green D, Casarotto MG, Laver DR, Dalhunty AF, 'The Random-Coil 'C' fragment of the dihydropyridine receptor II-III loop can activate or inhibit native skeletal ryanodine receptors', Biochemical journal, 375 305-316 (2003) [C1]
2004Laver DR, O'Neill ER, Lamb GD, 'Luminal Ca2+ - regulated Mg2+ inhibition of skeletal RyRs reconstituted as isolated channels or coupled clusters', J Gen Physiol, 124 741-758 (2004) [C1]
2008Laver DR, Honen BN, 'Luminal Mg2+, a key factor controlling RYR2-mediated Ca2+ release: Cytoplasmic and luminal regulation modeled in a tetrameric channel', Journal of General Physiology, 132 429-446 (2008) [C1]
2007Laver DR, 'Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sites', Biophysical Journal, 92 3541-3555 (2007) [C1]
2007Laver DR, Hamada T, Fessenden JD, Ikemoto N, 'The ryanodine receptor pore blocker neomycin also inhibits channel activity via a previously undescribed high-affinity Ca2+ binding site', Journal of Membrane Biology, 220 11-20 (2007) [C1]
2006Laver DR, Bradley KM, 'Disulfonic stilbene permeation and block of the anion channel from the sarcoplasmic reticulum of rabbit skeletal muscle', American Journal of Physiology-Cell Physiology, 290 C1666-C1677 (2006) [C1]
2005Haarmann CS, Dulhunty AF, Laver DR, 'Regulation of skeletal ryanodine receptors by dihydropyridine receptor II-III loop C-region peptides: relief of Mg2+ inhibition', Biochemical Journal, 387 429-436 (2005) [C1]
2005Lindquist CEL, Laver DR, Birnir B, 'The mechanism of SR95531 inhibition at GABA(A) receptors examined in human alpha(1)beta(1) and alpha(1)beta(1)gamma(2S) receptors', Journal of Neurochemistry, 94 491-501 (2005) [C1]
2009Watanabe H, Chopra N, Laver DR, Hwang HS, Davies SS, Roach DE, et al., 'Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans', Nature Medicine, 15 380-383 (2009) [C1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Book (1 outputs)

YearCitationAltmetricsLink
2002Dulhunty AR, Laver DR, A Ca2+-activated anion channel in the sarcoplasmic reticulum of skeletal muscle, ACADEMIC PRESS INC, 22 (2002)

Chapter (2 outputs)

YearCitationAltmetricsLink
2010Laver DR, 'Regulation of RyR Channel Gating by Ca2+, Mg2+ and ATP', Structure and Function of Calcium Release Channels, Academic Press, Waltham 69-89 (2010) [B1]
2009Laver DR, 'Electrical methods for determining surface charge density and electrolyte composition at the lipid bilayer-solution interface', Advances in Planar Lipid Bilayers and Liposomes, Elsevier, Amsterdam 87-105 (2009) [B1]

Journal article (83 outputs)

YearCitationAltmetricsLink
2014van Helden DF, Thomas PA, Dosen PJ, Imtiaz MS, Laver DR, Isbister GK, 'Pharmacological approaches that slow lymphatic flow as a snakebite first aid.', PLoS Negl Trop Dis, 8 e2722 (2014) [C1]
2014Mehra D, Imtiaz MS, van Helden DF, Knollmann BC, Laver DR, 'Multiple modes of ryanodine receptor 2 inhibition by flecainide.', Mol Pharmacol, 86 696-706 (2014)
2014Walweel K, Li J, Molenaar P, Imtiaz MS, Quail A, dos Remedios CG, et al., 'Differences in the regulation of RyR2 from human, sheep, and rat by Ca²¿ and Mg²¿ in the cytoplasm and in the lumen of the sarcoplasmic reticulum.', J Gen Physiol, 144 263-271 (2014)
2014Hwang HS, Nitu FR, Yang Y, Walweel K, Pereira L, Johnson CN, et al., 'Divergent Regulation of Ryanodine Receptor 2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants', CIRCULATION RESEARCH, 114 1114-1124 (2014)
2013Kong CHT, Laver DR, Cannell MB, 'Extraction of Sub-microscopic Ca Fluxes from Blurred and Noisy Fluorescent Indicator Images with a Detailed Model Fitting Approach', PLOS COMPUTATIONAL BIOLOGY, 9 (2013) [C1]
2013Laver DR, Kong CHT, Imtiaz MS, Cannell MB, 'Termination of calcium-induced calcium release by induction decay: An emergent property of stochastic channel gating and molecular scale architecture', JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 54 98-100 (2013) [C1]
2013Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne R, vanHelden DF, Laver DR, 'ß-Adrenergic stimulation increases RyR2 activity via intracellular Ca2+ and Mg2+ regulation.', PLoS One, 8 e58334 (2013) [C1]
2013Cannell MB, Kong CHT, Imtiaz MS, Laver DR, 'Control of Sarcoplasmic Reticulum Ca2+ Release by Stochastic RyR Gating within a 3D Model of the Cardiac Dyad and Importance of Induction Decay for CICR Termination', BIOPHYSICAL JOURNAL, 104 2149-2159 (2013) [C1]
2012Seymour VAL, Curmi JP, Howitt SM, Casarotto MG, Laver DR, Tierney ML, 'Selective modulation of different GABA A receptor isoforms by diazepam and etomidate in hippocampal neurons', International Journal of Biochemistry and Cell Biology, 44 1491-1500 (2012) [C1]
2011Hwang HS, Hasdemir C, Laver DR, Mehra DR, Turhan K, Faggioni M, et al., 'Inhibition of Cardiac Ca2+ Release Channels (RyR2) Determines Efficacy of Class I Antiarrhythmic Drugs in Catecholaminergic Polymorphic Ventricular Tachycardia', Circulation: Arrhythmia and Electrophysiology, 4 128-135 (2011) [C1]
2011Laver DR, Van Helden DF, 'Three independent mechanisms contribute to tetracaine inhibition of cardiac calcium release channels', Journal of Molecular and Cellular Cardiology, 51 357-369 (2011) [C1]
2010Imtiaz MS, Von Der Weid P-Y, Laver DR, Van Helden DF, 'SR Ca2+ store refill-a key factor in cardiac pacemaking', Journal of Molecular and Cellular Cardiology, 49 412-426 (2010) [C1]
2010Hilliard FA, Steele DS, Laver DR, Yang Z, Le Marchand SJ, Chopra N, et al., 'Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass', Journal of Molecular and Cellular Cardiology, 48 293-301 (2010) [C1]
2010Shtifman A, Ward CW, Laver DR, Bannister ML, Lopez JR, Kitazawa M, et al., 'Amyloid-ß protein impairs Ca2+ release and contractility in skeletal muscle', Neurobiology of Aging, 31 2080-2090 (2010) [C1]
2010Van Helden DF, Laver DR, Holdsworth JL, Imtiaz MS, 'Generation and propagation of gastric slow waves', Clinical and Experimental Pharmacology and Physiology, 37 516-524 (2010) [C1]
2010Hwang HS, Hasdemir C, Laver D, Mehra D, Turhan K, Faggioni M, et al., 'Inhibition of Cardiac Ca2+ Release Channels (RyR2) Determines Efficacy of Class I Antiarrhythmic Drugs in Catecholaminergic Polymorphic Ventricular Tachycardia', CIRCULATION, 122 (2010) [C3]
2009Laver DR, 'Luminal Ca2+ activation of cardiac ryanodine receptors by luminal and cytoplasmic domains', European Biophysics Journal, 39 19-26 (2009) [C1]
2009Everitt AB, Seymour VAL, Curmi J, Laver DR, Gage PW, Tierney ML, 'Protein interactions involving the gamma 2 large cytoplasmic loop of GABA(A) receptors modulate conductance', FASEB Journal, 23 4361-4369 (2009) [C1]
2009Chopra N, Laver DR, Davies SS, Knollmann BC, 'Amitriptyline activates cardiac ryanodine channels and causes spontaneous sarcoplasmic reticulum calcium release', Molecular Pharmacology, 75 183-195 (2009) [C1]
2009Watanabe H, Chopra N, Laver DR, Hwang HS, Davies SS, Roach DE, et al., 'Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans', Nature Medicine, 15 380-383 (2009) [C1]
2009Laver D, 'Chapter 4 Electrical Methods for Determining Surface Charge Density and Electrolyte Composition at the Lipid Bilayer-Solution Interface', Advances in Planar Lipid Bilayers and Liposomes, 9 87-105 (2009)
2008Laver DR, Honen BN, Lamb GD, Ikemoto N, 'A domain peptide of the cardiac ryanodine receptor regulates channel sensitivity to luminal Ca2+ via cytoplasmic Ca2+ sites', European Biophysics Journal with Biophysics Letters, 37 455-467 (2008) [C1]
2008Laver DR, Honen BN, 'Luminal Mg2+, a key factor controlling RYR2-mediated Ca2+ release: Cytoplasmic and luminal regulation modeled in a tetrameric channel', Journal of General Physiology, 132 429-446 (2008) [C1]
2007Laver DR, Hamada T, Fessenden JD, Ikemoto N, 'The ryanodine receptor pore blocker neomycin also inhibits channel activity via a previously undescribed high-affinity Ca2+ binding site', Journal of Membrane Biology, 220 11-20 (2007) [C1]
2007Laver DR, 'Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sites', Biophysical Journal, 92 3541-3555 (2007) [C1]
2007Laver DR, 'Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sites', Clinical and Experimental Pharmacology and Physiology, 34 889-896 (2007) [C1]
2006Laver DR, Bradley KM, 'Disulfonic stilbene permeation and block of the anion channel from the sarcoplasmic reticulum of rabbit skeletal muscle', American Journal of Physiology-Cell Physiology, 290 C1666-C1677 (2006) [C1]
2006Laver DR, 'Regulation of ryanodine receptors from skeletal and cardiac muscle during rest and excitation', Clinical and Experimental Pharmacology & Physiology, 33 1107-1113 (2006) [C1]
2006Lindquist CEL, Laver DR, Birnir B, 'The mechanism of SR95531 inhibition at GABA(A) receptors examined in human alpha(1)beta(1) and alpha(1)beta(1)gamma(2S) receptors (vol 94, pg 491, 2005) (Errartum)', Journal of Neurochemistry, 97 302-302 (2006) [C3]
2005Beard NA, Casarotto MG, Wei L, Varsanyi M, Laver DR, Dulhunty AF, 'Regulation of ryanodine receptors by calsequestrin: Effect of high luminal Ca2+ and phosphorylation', Biophysical Journal, 88 3444-3454 (2005) [C1]
2005Haarmann CS, Dulhunty AF, Laver DR, 'Regulation of skeletal ryanodine receptors by dihydropyridine receptor II-III loop C-region peptides: relief of Mg2+ inhibition', Biochemical Journal, 387 429-436 (2005) [C1]
2005Laver DR, 'Coupled calcium release channels and their regulation by luminal and cytosolic ions', European Biophysics Journal with Biophysics Letters, 34 359-368 (2005) [C1]
2005Lindquist CEL, Laver DR, Birnir B, 'The mechanism of SR95531 inhibition at GABA(A) receptors examined in human alpha(1)beta(1) and alpha(1)beta(1)gamma(2S) receptors', Journal of Neurochemistry, 94 491-501 (2005) [C1]
2004Beard NA, Laver DR, Dulhunty AF, 'Calsequestrin and the calcium release challen of skeletal and cardiac muscle', Progress in Biophysics & Molecular Biology, 85 33-69 (2004) [C1]
2004Laver DR, O'Neill ER, Lamb GD, 'Luminal Ca2+ - regulated Mg2+ inhibition of skeletal RyRs reconstituted as isolated channels or coupled clusters', J Gen Physiol, 124 741-758 (2004) [C1]
2003O'Neill ER, Sakowska MM, Laver DR, 'Regulation of the Calcium Release Channel from Skeletal Muscle by Suramin and the Disulfonated Stilbene Derivatives DIDS, DBDS, and DNDS', Biophysical Journal, 84 1674-1689 (2003) [C1]
2003Haarmann C, Green D, Casarotto MG, Laver DR, Dalhunty AF, 'The Random-Coil 'C' fragment of the dihydropyridine receptor II-III loop can activate or inhibit native skeletal ryanodine receptors', Biochemical journal, 375 305-316 (2003) [C1]
2003Honen BN, Saint DA, Laver DR, 'Supression of Calcium Sparks in Rat Ventricular Myocytes and Direct Inhitition of Sheep Cardiac RyR Channels by EPA, DHA and Oleic Acid', Journal of Membrane Biology, 196 95-103 (2003) [C1]
2002Beard NA, Sakowska MM, Dulhunty AF, Laver DR, 'Calsequestrin is an Inhibitor of Skeletal Muscle Ryanodine Receptor Calcium Release Channels', Biophysical Journal, 82 310-320 (2002) [C1]
2002Dulhunty AF, Haarmann CS, Green D, Laver DR, Board PG, Casarotto MG, 'Interactions between dihydropyridine receptors and ryanodine receptors in striated muscle', PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 79 45-75 (2002)
2001Laver DR, Lenz GKE, Dulhunty AF, 'Phosphate ion channels in sarcoplasmic reticulum of rabbit skeletal muscle', JOURNAL OF PHYSIOLOGY-LONDON, 535 715-728 (2001)
2001Laver DR, Lenz GKE, Lamb GD, 'Regulation of the calcium release channel from rabbit skeletal muscle by the nucleotides ATP, AMP, IMP and adenosine', JOURNAL OF PHYSIOLOGY-LONDON, 537 763-778 (2001)
2001Dulhunty AF, Laver D, Curtis SM, Pace S, Haarmann C, Gallant EM, 'Characteristics of irreversible ATP activation suggest that native skeletal ryanodine receptors can be phosphorylated via an endogenous CaMKII', BIOPHYSICAL JOURNAL, 81 3240-3252 (2001)
2001Laver DR, 'The power of single channel recording and analysis: Its application to ryanodine receptors in lipid bilayers', CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 28 675-686 (2001)
2000Laver DR, Eager KR, Taoube L, Lamb GD, 'Effects of cytoplasmic and luminal pH on Ca2+ release channels from rabbit skeletal muscle', BIOPHYSICAL JOURNAL, 78 1835-1851 (2000)
2000Lamb GD, Laver DR, Stephenson DG, 'Perspective - Questions about adaptation in ryanodine receptors', JOURNAL OF GENERAL PHYSIOLOGY, 116 883-890 (2000)
2000Panter S, Thomson R, de Bruxelles G, Laver D, Trevaskis B, Udvardi M, 'Identification with proteomics of novel proteins associated with the peribacteroid membrane of soybean root nodules', MOLECULAR PLANT-MICROBE INTERACTIONS, 13 325-333 (2000)
1999Dulhunty AF, Laver DR, Gallant EM, Casarotto MG, Pace SM, Curtis S, 'Activation and inhibition of skeletal RyR channels by a part of the skeletal DHPR II-III loop: Effects of DHPR Ser(687) and FKBP12', BIOPHYSICAL JOURNAL, 77 189-203 (1999)
1998Laver DR, Lamb GD, 'Inactivation of Ca2+ release channels (ryanodine receptors RyR1 and RyR2) with rapid steps in [Ca2+] and voltage', BIOPHYSICAL JOURNAL, 74 2352-2364 (1998)
1998Ahern GP, Laver DR, 'ATP inhibition and rectification of a Ca2+-activated anion channel in sarcoplasmic reticulum of skeletal muscle', BIOPHYSICAL JOURNAL, 74 2335-2351 (1998)
1997Laver DR, Owen VJ, Junankar PR, Taske NL, Dulhunty AF, Lamb GD, 'Ca2+- and Mg2+-Regulation of Calcium Release Channels from Normal and Malignant Hyperthermia Susceptible Pigs', Biophysical Journal, 73 1913-1924 (1997) [C1]
1997Laver DR, Owen VJ, Junankar PR, Taske NL, Dulhunty AF, Lamb GD, 'Reduced inhibitory effect of Mg2+ on ryanodine receptor Ca2+ release channels in malignant hyperthermia', BIOPHYSICAL JOURNAL, 73 1913-1924 (1997)
1997Laver DR, Cherry CA, Walker NA, 'The actions of calmodulin antagonists W-7 and TFP and of calcium on the gating kinetics of the calcium-activated large conductance potassium channel of the Chara protoplasmic drop: A substate-sensitive analysis', JOURNAL OF MEMBRANE BIOLOGY, 155 263-274 (1997)
1997Laver DR, Gage PW, 'Interpretation of substates in ion channels: Unipores or multipores?', PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 67 99-140 (1997)
1997McCulloch SR, Laver DR, Walker NA, 'Anion channel activity in the Chara plasma membrane: Co-operative subunit phenomena and a model', JOURNAL OF EXPERIMENTAL BOTANY, 48 383-397 (1997)
1997Laver DR, Baynes TM, Dulhunty AF, 'Magnesium inhibition of ryanodine-receptor calcium channels: Evidence for two independent mechanisms', JOURNAL OF MEMBRANE BIOLOGY, 156 213-229 (1997)
1996Laver D, Curtis B, 'Rapid solution change activates ryanodine receptors within 20 ms.', BIOPHYSICAL JOURNAL, 70 WPO48-WPO48 (1996)
1996Dulhunty AF, Junankar PR, Eager KR, Ahern GP, Laver DR, 'Ion channels in the sarcoplasmic reticulum of striated muscle', ACTA PHYSIOLOGICA SCANDINAVICA, 156 375-385 (1996)
1996Kourie JI, Laver DR, Ahern GP, Dulhunty AF, 'A calcium-activated chloride channel in sarcoplasmic reticulum vesicles from rabbit skeletal muscle', AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 270 C1675-C1686 (1996)
1996Kourie JI, Laver DR, Junankar PR, Gage PW, Dulhunty AF, 'Characteristics of two types of chloride channel in sarcoplasmic reticulum vesicles from rabbit skeletal muscle', BIOPHYSICAL JOURNAL, 70 202-221 (1996)
1996Laver DR, Curtis BA, 'Surface potentials measure ion concentrations near lipid bilayers during rapid solution changes', BIOPHYSICAL JOURNAL, 71 722-731 (1996)
1996Laver DR, Curtis BA, 'Response of ryanodine receptor channels to Ca2+ steps produced by rapid solution', BIOPHYSICAL JOURNAL, 71 732-741 (1996)
1995Laver DR, Roden LD, Ahem GP, Eager KR, Junankar PR, Dulhunty AF, 'Cytoplasmic Ca2+ Inhibits the Ryanodine Receptor from Cardiac Muscle', Journal of Membrane Biology, 147 7-22 (1995) [C1]
1994LAVER DR, FAIRLEYGRENOT KA, 'SURFACE-POTENTIALS NEAR THE MOUTH OF THE LARGE-CONDUCTANCE K+ CHANNEL FROM CHARA-AUSTRALIS - A NEW METHOD OF TESTING FOR DIFFUSION-LIMITED ION FLOW', JOURNAL OF MEMBRANE BIOLOGY, 139 149-165 (1994)
1994LAVER DR, 'THE BARREL-STAVE MODEL AS APPLIED TO ALAMETHICIN AND ITS ANALOGS REEVALUATED', BIOPHYSICAL JOURNAL, 66 355-359 (1994)
1992LAVER DR, 'DIVALENT-CATION BLOCK AND COMPETITION BETWEEN DIVALENT AND MONOVALENT CATIONS IN THE LARGE-CONDUCTANCE K+ CHANNEL FROM CHARA-AUSTRALIS', JOURNAL OF GENERAL PHYSIOLOGY, 100 269-300 (1992)
1991LAVER DR, WALKER NA, 'ACTIVATION BY CA2+ AND BLOCK BY DIVALENT IONS OF THE K+-CHANNEL IN THE MEMBRANE OF CYTOPLASMIC DROPS FROM CHARA-AUSTRALIS', JOURNAL OF MEMBRANE BIOLOGY, 120 131-139 (1991)
1991FAIRLEY K, LAVER D, WALKER NA, 'WHOLE-CELL AND SINGLE-CHANNEL CURRENTS ACROSS THE PLASMALEMMA OF CORN SHOOT SUSPENSION CELLS', JOURNAL OF MEMBRANE BIOLOGY, 121 11-22 (1991)
1991LAVER DR, 'A SURGICAL METHOD FOR ACCESSING THE PLASMAMEMBRANE OF CHARA-AUSTRALIS', PROTOPLASMA, 161 79-84 (1991)
1990GENTLE IR, LAVER DR, RITCHIE GLD, 'TEMPERATURE AND PRESSURE-DEPENDENCE OF THE ELECTROOPTICAL KERR EFFECT OF SULFUR-DIOXIDE', JOURNAL OF PHYSICAL CHEMISTRY, 94 3434-3437 (1990)
1990LAVER DR, 'COUPLING OF K+-GATING AND PERMEATION WITH CA-2+ BLOCK IN THE CA-2+-ACTIVATED K+ CHANNEL IN CHARA-AUSTRALIS', JOURNAL OF MEMBRANE BIOLOGY, 118 55-67 (1990)
1989CRAVEN IE, HESLING MR, LAVER DR, LUKINS PB, RITCHIE GLD, VRBANCICH J, 'POLARIZABILITY ANISOTROPY, MAGNETIC-ANISOTROPY, AND QUADRUPOLE-MOMENT OF CYCLOHEXANE', JOURNAL OF PHYSICAL CHEMISTRY, 93 627-631 (1989)
1989GENTLE IR, LAVER DR, RITCHIE GLD, '2ND HYPERPOLARIZABILITY AND STATIC POLARIZABILITY ANISOTROPY OF CARBON-DIOXIDE', JOURNAL OF PHYSICAL CHEMISTRY, 93 3035-3038 (1989)
1989LAVER DR, FAIRLEY KA, WALKER NA, 'ION PERMEATION IN A K+ CHANNEL IN CHARA-AUSTRALIS - DIRECT EVIDENCE FOR DIFFUSION LIMITATION OF ION FLOW IN A MAXI-K CHANNEL', JOURNAL OF MEMBRANE BIOLOGY, 108 153-164 (1989)
1987LAVER DR, WALKER NA, 'STEADY-STATE VOLTAG-DEPENDENT GATING AND CONDUCTION KINETICS OF SINGLE K+ CHANNELS IN THE MEMBRANE OF CYTOPLASMIC DROPS OF CHARA-AUSTRALIS', JOURNAL OF MEMBRANE BIOLOGY, 100 31-42 (1987)
1986COSTER HGL, LAVER DR, 'THE EFFECT OF BENZYL ALCOHOL AND CHOLESTEROL ON THE ACYL CHAIN ORDER AND ALKANE SOLUBILITY OF BIMOLECULAR PHOSPHATIDYLCHOLINE MEMBRANES', BIOCHIMICA ET BIOPHYSICA ACTA, 861 406-412 (1986)
1986COSTER HGL, LAVER DR, 'THE EFFECT OF TEMPERATURE ON LIPID NORMAL-ALKANE INTERACTIONS IN LIPID BILAYERS', BIOCHIMICA ET BIOPHYSICA ACTA, 857 95-104 (1986)
1985LUKINS PB, LAVER DR, BUCKINGHAM AD, RITCHIE GLD, 'COTTON-MOUTON EFFECT, MAGNETIC-ANISOTROPY, AND CHARGE-DISTRIBUTION OF CYCLOPROPANE', JOURNAL OF PHYSICAL CHEMISTRY, 89 1309-1312 (1985)
1985SMITH J, COSTER HGL, LAVER DR, 'THE DEPENDENCE OF THE CONDUCTANCE OF PHOSPHATIDYLCHOLINE BILAYERS UPON THE CONCENTRATION AND COMPOSITION OF THE EXTERNAL ELECTROLYTE', BIOCHIMICA ET BIOPHYSICA ACTA, 812 181-192 (1985)
1984SMITH J, LAVER DR, COSTER HGL, 'THE CONDUCTANCE OF LECITHIN BILAYERS - THE DEPENDENCE UPON TEMPERATURE', CHEMISTRY AND PHYSICS OF LIPIDS, 34 227-236 (1984)
1984LAVER DR, SMITH J, COSTER HGL, 'THE THICKNESS OF THE HYDROPHOBIC AND POLAR-REGIONS OF GLYCEROL MONOOLEATE BILAYERS DETERMINED FROM THE FREQUENCY-DEPENDENCE OF BILAYER CAPACITANCE', BIOCHIMICA ET BIOPHYSICA ACTA, 772 1-9 (1984)
1983ASHCROFT RG, COSTER HGL, LAVER DR, SMITH J, 'THE EFFECTS OF CHOLESTEROL INCLUSION ON THE MOLECULAR-ORGANIZATION OF BIMOLECULAR LIPID-MEMBRANES', BIOCHIMICA ET BIOPHYSICA ACTA, 730 231-238 (1983)
1982COSTER HGL, LAVER DR, SCHOENBORN BP, 'EFFECT OF 2H2O/H2O REPLACEMENT ON THE DIELECTRIC STRUCTURE OF LIPID BILAYER-MEMBRANES', BIOCHIMICA ET BIOPHYSICA ACTA, 686 141-143 (1982)
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Conference (32 outputs)

YearCitationAltmetricsLink
2014Walweel KD, vanHelden DF, Imtiaz MS, Dos Remedios C, Molenaar P, Laver DR, 'Inhibition of RyR2 from Failing and Non-Failing Human Hearts by Calmodulin', BIOPHYSICAL JOURNAL, San Francisco, CA (2014)
2014Laver DR, Cannell MB, Imtiaz MS, 'Anti-Arrhythmic Block of Ryr2 by Flecainide Versus Pro-Arrhythmic Block by Tetracaine in a 3D Model of a Cardiac Cell', BIOPHYSICAL JOURNAL, San Francisco, CA (2014)
2013Van Heiden DF, Laver DR, Imtiaz MS, Hashitani H, 'Cellular Interactions Controlling Tonic and Peristaltic Contractions of Gastric Smooth Muscle', JOURNAL OF PHYSIOLOGICAL SCIENCES (2013) [E3]
2013Laver DR, Kong CHT, Imtiaz MS, Cannell MB, 'Termination of Calcium Sparks: An Emergent Property from Stochastic RyR Gating and Dyad Geometry', BIOPHYSICAL JOURNAL, Philadelphia, PA (2013) [E3]
2012Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne RF, Van Helden DF, Laver DR, 'Adrenergic stimulation increases RYR2 activity via intracellular Ca2+ and Mg2+ regulation', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
2012Walweel K, Beard NA, Li J, Van Helden DF, Imtiaz MS, Molenaar P, Laver DR, 'Regulation of human RYR2 by intracellular Ca2+ and Mg2+', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]

Co-authors: Dirk vanHelden

2012Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne RF, Van Helden DF, Laver DR, 'Adrenergic stimulation alters RyR2 regulation by Ca2+ and Mg2+', Heart, Lung and Circulation: Abstracts of ISHR Auckland Workshop, Auckland, NZ (2012) [E3]
2012Mehra DR, Van Helden DF, Laver DR, 'Role of cardiac Na+ channel blockers and Mg2+ in inhibiting the cardiac calcium release channel', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]

Co-authors: Dirk vanHelden

2012Imtiaz MS, Allen DG, Van Helden DF, Laver DR, 'Role of intracellular Ca2+ in sinoatrial node pacemaking', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]

Co-authors: Dirk vanHelden

2012Imtiaz MS, Van Helden DF, Laver DR, 'Three-dimensional modeling of Ca2+ dynamics in single cardiac cells', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]

Co-authors: Dirk vanHelden

2011Morris D, Saint D, Laver DR, 'Negative inotropic effect of riluzole: Blockade of the ryanadine receptor?', Heart, Lung and Circulation, Perth, WA (2011) [E3]
2011Walweel K, Li J, Van Helden DF, Imtiaz MS, Molenaar P, Laver DR, 'Regulation of RyRs by intracellular Ca2+ and Mg2+ compared in sheep, rat and human heart', Proceedings of the Australian Physiological Society 2011, Perth (2011) [E3]

Co-authors: Dirk vanHelden

2011Mehra DR, Van Helden DF, Hwang HS, Knollmann B, Laver DR, 'Role of cardiac Na+ channel blockers in inhibiting the cardiac calcium release channel', Proceedings of the Australian Physiological Society 2011, Perth (2011) [E3]

Co-authors: Dirk vanHelden

2009Hollins SL, Johnstone DM, Van Helden DF, Kerr KP, Laver DR, Metelerkamp KM, et al., 'Cardiac gene expression in mouse models of iron loading', ASMR XVII NSW Scientific Meeting: Programme and Abstracts, Sydney, NSW (2009) [E3]
2009Mehra DR, Van Helden DF, Knollmann B, Laver DR, 'Flecainide inhibits CPVT induced cardiac arrhythmias by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass', 33rd Annual Meeting of the Australian Society for Biophysics: Program, Ballarat, VIC (2009) [E3]

Co-authors: Dirk vanHelden

2009Laver DR, Quail AW, Sitsapesan H, Van Helden DF, 'The effect of volatile anaesthetics on the cardiac ryanodine receptor', Biophysical Journal, Boston, MA (2009) [E3]
2009Hollins SL, Johnstone DM, Graham R, Van Helden DF, Kerr KP, Laver DR, et al., 'Cardiac gene expression in mouse models of iron loading disorders', 2009 International Biolron Society Meeting: Program Book, Porto, Portugal (2009) [E3]
2009Hilliard FA, Laver DR, Le Marchand SJ, Piston DW, Knollmann BG, 'Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass', Circulation, Orlando, FL (2009) [E3]
2008Laver DR, Quail AW, Sitsapesan H, Van Helden DF, 'Effect of volatile anaesthetics on the calcium release channel in the heart', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]
2008Van Helden DF, Laver DR, Imtiaz MS, 'Ca2+ phase waves: A fundamental mechanism underlying propagation of gastric slow waves', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]

Co-authors: Dirk vanHelden

2008Chopra N, Watanabe H, Laver DR, Hwang HS, Roden DM, Knollmann BC, 'Flecainide blocks cardiac ryanodine channels and prevents catecholaminergic ventricular tachycardia in cardiac calsequestrin null mice', Circulation, - (2008) [E3]
2007Tierney ML, Everitt AB, Seymour VAL, Laver DR, 'Subunit-specific interactions between gabaa receptors underlie diazepam modulated high conductance gaba channels (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
2007Chopra N, Laver DR, Watanabe H, Nair UB, Stein CM, Knollmann BC, 'Amitriptyline activates cardiac ryanodine receptors independently of its action on cardiac calsequestrin: Role for amitriptyline linked sudden cardiac death', Circulation, Orlando, FL. (2007) [E3]
2007Laver DR, 'Store activation mechanism for cardiac ryanodine receptors', BIOPHYSICAL JOURNAL, Baltimore, MD (2007)
2005Honen BN, Dalton RL, Van Helden DF, Laver DR, 'Acute application of n-3 polyunsaturated fatty acids modify calcium sparks in permeabilised rat cardiac myocytes', Proceedings of the Australian Physiological Society, Canberra (2005) [E3]

Co-authors: Dirk vanHelden

2005Laver DR, 'Regulation of ryanodine receptors from skeletal and cardiac muscle by components of the cytoplasm and lumen', Proceedings of the Australian Physiological Society, Canberra (2005) [E3]
2005Laver DR, Lamb GD, 'Regulation of single and coupled RyRs in bilayers by luminal Ca2+', BIOPHYSICAL JOURNAL, Long Beach, CA (2005)
2005Honen BN, Lamb GD, Laver DR, Ikemoto N, 'Aberrant calcium release underlying sudden cardiac death probed with RyR domain peptides', BIOPHYSICAL JOURNAL, Long Beach, CA (2005)
2004Honen BN, Saint DA, Van Helden DF, Laver DR, 'The effects of fatty acids on SR calcium release channels from cardiac muscle', Biophysical Journal, Maryland, USA (2004) [E3]

Co-authors: Dirk vanHelden

2004Haarmann CS, Dulhunty AF, Laver DR, 'The manifold effects of peptide C region of the DHPR II-III loop on RyRs', Biophysical Journal, Maryland, USA (2004) [E3]
2003Kobayashi S, Yamamoto T, Laver DR, Lamb GD, Ikemoto N, 'RyR1 and RyR2 seem to share a common mechanism of cytoplasmic domain-mediated channel regulation: peptide probe studies', BIOPHYSICAL JOURNAL, SAN ANTONIO, TEXAS (2003)
2003O'Neill E, Lamb G, Laver D, 'Magnesium inhibition of skeletal RyRs modified by DIDS, ryanodine and ATP', BIOPHYSICAL JOURNAL, SAN ANTONIO, TEXAS (2003)
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Grants and Funding

Summary

Number of grants37
Total funding$3,232,400

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2015 (1 grants)

Regulation of RyR2 channels by calmodulin in healthy and diseased hearts$594,492
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Bjorn Knollman
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$594,49220152017
GNo:G1400064

2014 (1 grants)

Biophysical Society 58th Annual Meeting, San Fransisco USA, 15-19 February 2014$1,728
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Associate Professor Derek Laver
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,72820142014
GNo:G1400396

2013 (2 grants)

Investigating the basis for diabetes-associated gastric motility disorders$10,000
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden, Associate Professor Derek Laver
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$10,00020132013
GNo:G1300485

Biophysical Society 57th Annual Meeting, Pennsylvania Convention Centre, Philadelphia, 2 - 6 February 2013$2,000
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Associate Professor Derek Laver
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,00020132013
GNo:G1300542

2012 (2 grants)

Gastric Slow Waves and Motility Disorders$20,000
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden, Associate Professor Derek Laver
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020122012
GNo:G1200674

Gordon Research Conference on Muscle, Les Diablerets Conference Center, Les Diablerets Switzerland, 3 - 8 June 2012$2,000
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Associate Professor Derek Laver
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,00020122012
GNo:G1200933

2011 (2 grants)

Ryanodine receptor inhibitors as therapy for Ca2+ store overload induced arrhythmias$536,706
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Bjorn Knollman
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$536,70620112013
GNo:G1000274

Biophysics Society, Baltimore Convention Centre, 5 - 9 March 2011$2,000
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Associate Professor Derek Laver
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,00020112011
GNo:G1100184

2010 (5 grants)

Regulation of calcium release channels (RyR2) in healthy and failing hearts$325,575
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Derek Laver, Dr Nicole Beard, Professor Angela Dulhunty
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$325,57520102012
GNo:G0190194

HMRI MRSP Infrastructure Grant (10-11) - Cardiovascular$76,117
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Eugene Nalivaiko, Associate Professor Liz Milward, Professor Robert Callister, Professor Manohar Garg, Conjoint Professor Tony Quail
SchemeRole
NSW MRSP Infrastructure GrantChief Investigator
Total AmountFunding StartFunding Finish
$76,11720102010
GNo:G1100525

HMRI MRSP Infrastructure Grant 09/10 - Cardiovascular$62,358
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Derek Laver
SchemeRole
NSW MRSP Infrastructure GrantChief Investigator
Total AmountFunding StartFunding Finish
$62,35820102010
GNo:G1000559

ABI 7500 Real Time PCR System $34,000
Funding Body: NHMRC (National Health & Medical Research Council)

Effective anti-arrhythmic drugs: How do they work?$30,000
Funding Body: BellBerry Limited

Project Team
Associate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Bjorn Knollman
SchemeRole
Near MissChief Investigator
Total AmountFunding StartFunding Finish
$30,00020102012
GNo:G0900218

2009 (2 grants)

Propagation and directionality of gastric slow waves$20,000
Funding Body: University of Newcastle

Project Team
Professor Dirk Van Helden, Associate Professor Derek Laver
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020092009
GNo:G0189817

Gordon Conference on Muscle, New Hampshire, USA, 14-19 June 2009$1,175
Funding Body: University of Newcastle

Project Team
Associate Professor Derek Laver
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,17520092009
GNo:G0900243

2008 (2 grants)

The effects of iron status on calcium handling systems in heart and brain$25,000
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Derek Laver, Associate Professor Liz Milward, Professor Dirk Van Helden, Professor Rodney Scott
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$25,00020082008
GNo:G0188463

Biophysics Society, Long Beach Conference Centre, 2/2/2008 - 6/2/2008$2,500
Funding Body: University of Newcastle

Project Team
Associate Professor Derek Laver
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,50020082008
GNo:G0188597

2007 (6 grants)

HMRI - Cardiovascular Research Program$518,556
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Derek Laver, Conjoint Professor Tony Quail, Professor Dirk Van Helden, Professor Manohar Garg, Professor Robin Callister
SchemeRole
NSW MRSP Infrastructure GrantChief Investigator
Total AmountFunding StartFunding Finish
$518,55620072009
GNo:G0187946

High speed/sensitivity CCD camera$30,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Dirk Van Helden, Professor Eileen McLaughlin, Professor Gordon Burns, Doctor Rick Thorne, Dr Marcus Howlett, Doctor Mohammad Imtiaz, Associate Professor Alan Brichta, Professor Robert Callister, Doctor Brett Graham, Associate Professor Derek Laver, Associate Professor Liz Milward, Doctor John Holdsworth
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$30,00020072007
GNo:G0188196

3D Imaging Software/Work station$20,000
Funding Body: Hunter Medical Research Institute

Project Team
Professor David Pow, Doctor Chris Dayas, Doctor Phil Jobling, Associate Professor Derek Laver
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020072007
GNo:G0188026

Magnesium and calcium regulation of calcium release channels in cardiac and skeletal muscle in health and disease$20,000
Funding Body: University of Newcastle

Project Team
Associate Professor Derek Laver
SchemeRole
Near Miss GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020072007
GNo:G0187200

(93) Hunter Medical Research Institute - Cardiovascular$3,551
Funding Body: University of Newcastle

Project Team
Associate Professor Derek Laver
SchemeRole
Publication Performance GrantChief Investigator
Total AmountFunding StartFunding Finish
$3,55120072008
GNo:G0187978

Biophysics Society, Baltimore Conference Centre, 3/3/2007 - 7/3/2007$2,500
Funding Body: University of Newcastle

Project Team
Associate Professor Derek Laver
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,50020072007
GNo:G0187324

2006 (3 grants)

Mechanisms of action of w-3 fatty acids in control of atrial arrhythmias $16,000
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Derek Laver, Professor Dirk Van Helden, Doctor Bonny Honen
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$16,00020062006
GNo:G0186102

Regulation of calcium release channels by Ca2+ store load and phosphorylation$10,000
Funding Body: University of Newcastle

Project Team
Associate Professor Derek Laver
SchemeRole
Near Miss GrantChief Investigator
Total AmountFunding StartFunding Finish
$10,00020062006
GNo:G0186579

Biophysics Society 18-22 Feb 2006$1,500
Funding Body: University of Newcastle

Project Team
Associate Professor Derek Laver
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,50020062006
GNo:G0186562

2005 (2 grants)

Intrinsic properties of the pore forming domain of the Ryanodine Receptor Calcium Channel$135,000
Funding Body: ARC (Australian Research Council)

Project Team
Associate Professor Derek Laver
SchemeRole
Discovery ProjectsChief Investigator
Total AmountFunding StartFunding Finish
$135,00020052007
GNo:G0185058

2005 Annual meeting of the Biophysical Society, 12-16 Feb 2005, USA$2,278
Funding Body: University of Newcastle

Project Team
Associate Professor Derek Laver
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,27820052005
GNo:G0185126

2004 (1 grants)

Regulation of normal and diseased cardiac Ca+ channels$12,903
Funding Body: NIH National Institutes of Health

Project Team
Associate Professor Derek Laver
SchemeRole
Collaborative NIH Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$12,90320042004
GNo:G0185411

2003 (4 grants)

Aberrant behaviour of cardiac calcium release channels induced by ryanodine receptor peptide probes$160,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Derek Laver
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$160,00020032005
GNo:G0183037

Mechanisms of action of omega-3 fatty acids in reduction of hypertension.$17,000
Funding Body: Hunter Medical Research Institute

Project Team
Associate Professor Derek Laver, Professor Dirk Van Helden
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$17,00020032003
GNo:G0182641

C. elegans as an expression system for proteins that govern calcium release from internal stores.$11,000
Funding Body: University of Newcastle

Project Team
Associate Professor Derek Laver
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$11,00020032003
GNo:G0182453

Gordon Conference on Muscle Contraction, New London, NH, USA 8 - 13 June, 2003$2,500
Funding Body: University of Newcastle

Project Team
Associate Professor Derek Laver
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,50020032003
GNo:G0182761

2002 (4 grants)

Mechanisms governing regulation of ryanodine receptors function.$292,000
Funding Body: ARC (Australian Research Council)

Project Team
Associate Professor Derek Laver
SchemeRole
Australian Senior Research FellowshipChief Investigator
Total AmountFunding StartFunding Finish
$292,00020022005
GNo:G0181740

Mechanisms governing regulation of ryanodine receptors function.$110,861
Funding Body: ARC (Australian Research Council)

Project Team
Associate Professor Derek Laver
SchemeRole
Large GrantChief Investigator
Total AmountFunding StartFunding Finish
$110,86120022003
GNo:G0181739

Role of calcium stores and phosphate channells in muscular fatigue.$107,100
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Associate Professor Derek Laver
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$107,10020022004
GNo:G0181815

Dynamic Regulation Mechanisms of IP3-Receptor Calcium Release Channels$14,000
Funding Body: University of Newcastle

Project Team
Associate Professor Derek Laver
SchemeRole
New Staff GrantChief Investigator
Total AmountFunding StartFunding Finish
$14,00020022002
GNo:G0182022
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Research Supervision

Number of current supervisions3
Total current UoN Masters EFTSL0.5
Total current UoN PhD EFTSL0.5

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20132015M Philosophy (Human Physiolog)Principal SupervisorMechanosensitivity of TRPC6 Channels and its Role in Mechanoelectric Feedback of the Heart
20122016PhD (Human Physiology)Co-SupervisorEffects of Calmodulin on Function of Cardiac Ryanodine Receptor
20112015PhD (Human Physiology)Co-SupervisorThe Lymphatic Function in Diabetes

Past Supervision

YearProgramSupervisor TypeResearch Title
2014PhD (Human Physiology)Principal SupervisorMechanisms of Cardiac Ryanodine Receptor Inhibition by Anti Arrhythmic Drugs
2014PhD (Human Physiology)Principal SupervisorRegulation of Calcium Release Channels (RyR2) in Healthy and Failing Human Hearts
2013PhD (Human Physiology)Principal SupervisorRegulation of Cardiac Calcium Release Channels During Acute Beta-Adrenergic Stimulation
2004Honours Biol Sc Not Elsewhere Classifd
University of Newcastle
Co-SupervisorThe effect of poly unstaturated fatty acids on Ca2+ sparks
2003PHD Biol Sc Not Elsewhere Classifd
Australian National University
Co-SupervisorThe effects of protein-protein interactions on the functioning of ryanodine receptors
2003PHD Biol Sc Not Elsewhere Classifd
Australian National University
Co-SupervisorA study of the effect of ryanodine receptor oxidation on its regulation by myoplasmic substances
2000PHD Biol Sc Not Elsewhere Classifd
Australian National University
Co-SupervisorA study of desensitization in GABAA receptors
1950PHD Biol Sc Not Elsewhere Classifd
Australian National University
Co-SupervisorDeterminates of GABAA receptor single channel conductance
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Associate Professor Derek Laver

Work Phone(02) 4921 8732
Fax(02) 4921 7406
Email
PositionAssociate Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaHuman Physiology
Office
MS407,
Medical Sciences,
Callaghan
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/derek-laver