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Associate Professor Derek Laver

Associate Professor

School of Biomedical Sciences and Pharmacy (Human Physiology)

Career Summary

Biography

Within the School of Biomedical Sciences and Pharmacy I am convenor for Research Higher Degrees and the Student Academic Conduct Officer (SACO). Within the University I am coordinator for the Cardiovascular RQF at the University of Newcastle and I represent the Hunter region on the NSW Cardiovascular Research Network. Currently I serve as Chair of the cardiovascular program within the Hunter Medical Research Institute. My research aims are shared by Mr Paul Johnson (research assistant), and three PhD students (Ms Kafa Walweel, Ms Jiao Li and Ms Devya Mehra). These aims are also shared by collaborators at several Australian Universities and internationally, with current projects involving researchers in the USA (Dr Ikemoto from Harvard School of Medicine, Dr Knollmann from Vanderbilt University and Dr Shtifman from St. Elizabeth's Medical Center in Boston) and Sweden (Dr. Birnir from Lund University). I have been a council member and webmaster for Australian Physiological Society since 2000. I am a reviewer for many international journals (e.g. Journal of General Physiology, Biophysical Journal) and for the funding bodies (ARC, NH&MRC and Wellcome trust). I served as a member on peer review panels in Australia and internationally. I have chaired the organising committees for 2 Australian conferences (Curtin Conference 2000, Australian Physiological Society 2007). My research has attracted a number of highly prised fellowships from the ARC, including a Queen Elizabeth II Fellowship, Senior Research Fellowship and a Professorial Fellowship and also a Brawn Senior Fellowship from the University of Newcastle Research Expertise
The theme to my research career has been the use of biophysical methods to study membrane transport and ion channel function. I use electrophysiolological techniques to measure ion channel function. Channel function is analysed using markov theory to unravel and identify the complex mechanisms that control ion channels within cells.

Teaching Expertise
I have lectured and coordinated small undersgraduate courses (20-50 students) in my research area. I have coordinated and run laboratory classes in physiology and physics. I have supervised post graduate and honours students in physiology and biophysics

Administrative Expertise
2004-present Co- Chairman of the Cardiovascular program of the Hunter Medical Research Institute.

Collaborations
I have had a long standing interest in how ion channels are able to be selective to specific ion species and how they can open and close in response to stimuli from within the cell and the external environment. My understanding of ion channel function is primarily built upon biophysical measurement of ion flow through single ion channels using techniques such as patch-clamp of cell membranes and fusion of ion channels with artificially produced lipid membranes. Since 1995, I have devoted much of my attention to understanding how intracellular calcium and magnesium ions regulate the opening of calcium release channels in cardiac and skeletal muscle. These calcium release channels (called ryanodine receptors) mediate the release of calcium from internal stores within the cells which, in turn, provides the signal for muscle contraction. In the heart, these channels are important for timing of the heart beat and inherited mutations in these channels are known to lead to cardiac arrhythmia and sudden death. I have discovered several mechanisms by which calcium release channels are regulated by intracellular Ca2+ and Mg2+ and the key differences between those found in cardiac and skeletal muscle. These discoveries have provided insight into mechanisms for cardiac contraction and rythmicity, how their mal regulation leads to cardiac arrhythmias and how pharmacological modulation of the calcium release channels can reverse cardiac arrhythmias arising from congenital heart diseases such as CPVT.


Qualifications

  • PhD, University of New South Wales
  • Bachelor of Science (Honours)(Physics), University of New South Wales

Keywords

  • Ion channels
  • Membrane transport
  • cardiac muscle
  • disease
  • electrophysiology
  • ion channels
  • skeletal muscle

Fields of Research

CodeDescriptionPercentage
111599Pharmacology and Pharmaceutical Sciences not elsewhere classified60
111699Medical Physiology not elsewhere classified20
029999Physical Sciences not elsewhere classified20

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/01/2014 - Associate ProfessorUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

DatesTitleOrganisation / Department
1/01/2006 - 1/12/2010ARC - Aust Professorial Fellowship (level D E)ARC
Australia
1/01/2001 - 1/12/2005Prestigious fellowshipProfessorial Research Fellowship
Australia
1/01/2001 - 1/12/2005Professorial Research Fellow (ARC)University of Newcastle
Health
Australia
1/01/1999 - 1/12/2000Senior Research Officer (National Health & Medical Research Council)Australian National University
Biochemistry and Molecular Biology
Australia
1/01/1997 - 1/12/1998Senior Research OfficerAustralian National University
John Curtin School of Medical Research
Australia
1/01/1992 - 1/12/2005Prestigious fellowshipSenior Research Fellow (ARC)
Australia

Invitations

External Reviewer - Programs

YearTitle / Rationale
2004Biomembrane program,
Organisation: AgResearch

Participant

YearTitle / Rationale
2006Gordon Conference on Muscle
Organisation: Gordon conferences Description: Platform presentation at a Gordon conference is restricted to high profile scientists with high impact work
2003Gordon conference on excitation contraction coupling
Organisation: Gordon conference Description: Platform presentation at a Gordon conference is restricted to high profile scientists with high impact work
2001IUPS satelite confernece
Organisation: IUPS
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Book (1 outputs)

YearCitationAltmetricsLink
2002Dulhunty AR, Laver DR, A Ca2+-activated anion channel in the sarcoplasmic reticulum of skeletal muscle, ACADEMIC PRESS INC, 22 (2002)
DOI10.1016/S1063-5823(02)53028-3Author URL

Chapter (2 outputs)

YearCitationAltmetricsLink
2010Laver DR, 'Regulation of RyR Channel Gating by Ca2+, Mg2+ and ATP', Structure and Function of Calcium Release Channels, Academic Press, Waltham 69-89 (2010) [B1]
CitationsScopus - 6Web of Science - 5
2009Laver DR, 'Electrical methods for determining surface charge density and electrolyte composition at the lipid bilayer-solution interface', Advances in Planar Lipid Bilayers and Liposomes, Elsevier, Amsterdam 87-105 (2009) [B1]
DOI10.1016/S1554-4516(09)09004-8

Journal article (88 outputs)

YearCitationAltmetricsLink
2015Nikolaev YA, Dosen PJ, Laver DR, Van Helden DF, Hamill OP, 'Single mechanically-gated cation channel currents can trigger action potentials in neocortical and hippocampal pyramidal neurons', Brain Research, 1608 1-13 (2015)

The mammalian brain is a mechanosensitive organ that responds to different mechanical forces ranging from intrinsic forces implicated in brain morphogenesis to extrinsic forces that can cause concussion and traumatic brain injury. However, little is known of the mechanosensors that transduce these forces. In this study we use cell-attached patch recording to measure single mechanically-gated (MG) channel currents and their affects on spike activity in identified neurons in neonatal mouse brain slices. We demonstrate that both neocortical and hippocampal pyramidal neurons express stretch-activated MG cation channels that are activated by suctions of ~25 mm Hg, have a single channel conductance for inward current of 50-70 pS and show weak selectivity for alkali metal cations (i.e., Na+++). Significantly, single MG channel currents activated on the soma trigger spiking/action potentials in both neocortical and hippocampal pyramidal neurons. Not all neuron types studied here expressed MG channel currents. In particular, locus coeruleus and cerebellar Purkinje neurons showed no detectable MG channel activity. Moreover their robust rhythmic spike activity was resistant to mechanical modulation. Our observation that a single MG channel current can trigger spiking predicates the need for reassessment of the long held view that the impulse output of central neurons depends only upon their intrinsic voltage-gated channels and/or their integrated synaptic input.

DOI10.1016/j.brainres.2015.02.051
Co-authorsDirk Vanhelden
2015Zhang H-M, Imtiaz MS, Laver DR, McCurdy DW, Offler CE, Van Helden DF, Patrick JW, 'Polarized and persistent Ca2+ plumes define loci for formation of wall ingrowth papillae in transfer cells', Journal of Experimental Botany, 66 1179-1190 (2015)

Transfer cell morphology is characterized by a polarized ingrowth wall comprising a uniform wall upon which wall ingrowth papillae develop at right angles into the cytoplasm. The hypothesis that positional information directing construction of wall ingrowth papillae is mediated by Ca2+ signals generated by spatiotemporal alterations in cytosolic Ca2+ ([Ca2+]cyt) of cells trans-differentiating to a transfer cell morphology was tested. This hypothesis was examined using Vicia faba cotyledons. On transferring cotyledons to culture, their adaxial epidermal cells synchronously trans-differentiate to epidermal transfer cells. A polarized and persistent Ca2+ signal, generated during epidermal cell trans-differentiation, was found to co-localize with the site of ingrowth wall formation. Dampening Ca2+ signal intensity, by withdrawing extracellular Ca2+ or blocking Ca2+ channel activity, inhibited formation of wall ingrowth papillae. Maintenance of Ca2+ signal polarity and persistence depended upon a rapid turnover (minutes) of cytosolic Ca2+ by co-operative functioning of plasma membrane Ca2+-permeable channels and Ca2+-ATPases. Viewed paradermally, and proximal to the cytosol-plasma membrane interface, the Ca2+ signal was organized into discrete patches that aligned spatially with clusters of Ca2+-permeable channels. Mathematical modelling demonstrated that these patches of cytosolic Ca2+ were consistent with inward-directed plumes of elevated [Ca2+]cyt. Plume formation depended upon an alternating distribution of Ca2+-permeable channels and Ca2+-ATPase clusters. On further inward diffusion, the Ca2+ plumes coalesced into a uniform Ca2+ signal. Blocking or dispersing the Ca2+ plumes inhibited deposition of wall ingrowth papillae, while uniform wall formation remained unaltered. A working model envisages that cytosolic Ca2+ plumes define the loci at which wall ingrowth papillae are deposited.

DOI10.1093/jxb/eru460
CitationsScopus - 1Web of Science - 3
Co-authorsDirk Vanhelden, David Mccurdy, John Patrick
2015Nikolaev YA, Dosen PJ, Laver DR, van Helden DF, Hamill OP, 'Single mechanically-gated cation channel currents can trigger action potentials in neocortical and hippocampal pyramidal neurons.', Brain Res, 1608 1-13 (2015)
DOI10.1016/j.brainres.2015.02.051Author URL
Co-authorsDirk Vanhelden
2015Oo YW, Gomez-Hurtado N, Walweel K, van Helden DF, Imtiaz MS, Knollmann BC, Laver DR, 'Essential Role of Calmodulin in RyR Inhibition by Dantrolene.', Mol Pharmacol, 88 57-63 (2015)
DOI10.1124/mol.115.097691Author URL
Co-authorsDirk Vanhelden
2014Walweel K, Li J, Molenaar P, Imtiaz MS, Quail A, dos Remedios CG, et al., 'Differences in the regulation of RyR2 from human, sheep, and rat by Ca²¿ and Mg²¿ in the cytoplasm and in the lumen of the sarcoplasmic reticulum.', J Gen Physiol, 144 263-271 (2014) [C1]
DOI10.1085/jgp.201311157Author URL
CitationsScopus - 2Web of Science - 1
Co-authorsTony Quail, Dirk Vanhelden
2014van Helden DF, Thomas PA, Dosen PJ, Imtiaz MS, Laver DR, Isbister GK, 'Pharmacological approaches that slow lymphatic flow as a snakebite first aid.', PLoS Negl Trop Dis, 8 e2722 (2014) [C1]
DOI10.1371/journal.pntd.0002722Author URL
Co-authorsDirk Vanhelden, Geoff Isbister
2014Hwang HS, Nitu FR, Yang Y, Walweel K, Pereira L, Johnson CN, et al., 'Divergent Regulation of Ryanodine Receptor 2 Calcium Release Channels by Arrhythmogenic Human Calmodulin Missense Mutants', CIRCULATION RESEARCH, 114 1114-1124 (2014) [C1]
DOI10.1161/CIRCRESAHA.114.303391Author URL
CitationsScopus - 11Web of Science - 10
2014Mehra D, Imtiaz MS, Van Helden DF, Knollmann BC, Laver DR, 'Multiple modes of ryanodine receptor 2 inhibition by flecainide', Molecular Pharmacology, 86 696-706 (2014) [C1]

Catecholaminergic polymorphic ventricular tachycardia (CPVT) causes sudden cardiac death due to mutations in cardiac ryanodine receptors (RyR2), calsequestrin, or calmodulin. Flecainide, a class I antiarrhythmic drug, inhibits Na+ and RyR2 channels and prevents CPVT. The purpose of this study is to identify inhibitory mechanisms of flecainide on RyR2. RyR2 were isolated from sheep heart, incorporated into lipid bilayers, and investigated by singlechannel recording under various activating conditions, including the presence of cytoplasmic ATP (2mM) and a range of cytoplasmic [Ca2+], [Mg2+], pH, and [caffeine]. Flecainide applied to either the cytoplasmic or luminal sides of the membrane inhibited RyR2 by two distinct modes: 1) a fast block consisting of brief substate and closed events with a mean duration of ~1 ms, and 2) a slow block consisting of closed events with a mean duration of ~1 second. Both inhibition modes were alleviated by increasing cytoplasmic pH from 7.4 to 9.5 but were unaffected by luminal pH. The slow block was potentiated in RyR2 channels that had relatively low open probability, whereas the fast block was unaffected by RyR2 activation. These results show that these two modes are independent mechanisms for RyR2 inhibition, both having a cytoplasmic site of action. The slow mode is a closed-channel block, whereas the fast mode blocks RyR2 in the open state. At diastolic cytoplasmic [Ca2+] (100 nM), flecainide possesses an additional inhibitory mechanism that reduces RyR2 burst duration. Hence, multiple modes of action underlie RyR2 inhibition by flecainide.

DOI10.1124/mol.114.094623
CitationsScopus - 1Web of Science - 3
Co-authorsDirk Vanhelden
2014Walweel K, Laver DR, 'Mechanisms of SR calcium release in healthy and failing human hearts', Biophysical Reviews, 7 33-41 (2014)

Normal heart contraction and rhythm relies on the proper flow of calcium ions (Ca2+) into cardiac cells and between their intracellular organelles, and any disruption can lead to arrhythmia and sudden cardiac death. Electrical excitation of the surface membrane activates voltage-dependent L-type Ca2+ channels to open and allow Ca2+ to enter the cytoplasm. The subsequent increase in cytoplasmic Ca2+ concentration activates calcium release channels (RyR2) located at specialised Ca2+ release sites in the sarcoplasmic reticulum (SR), which serves as an intracellular Ca2+ store. Animal models have provided valuable insights into how intracellular Ca2+ transport mechanisms are altered in human heart failure. The aim of this review is to examine how Ca2+ release sites are remodelled in heart failure and how this affects intracellular Ca2+ transport with an emphasis on Ca2+ release mechanisms in the SR. Current knowledge on how heart failure alters the regulation of RyR2 by Ca2+ and Mg2+ and how these mechanisms control the activity of RyR2 in the confines of the Ca2+ release sites is reviewed.

DOI10.1007/s12551-014-0152-4
2013Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne R, vanHelden DF, Laver DR, 'ß-Adrenergic stimulation increases RyR2 activity via intracellular Ca2+ and Mg2+ regulation.', PLoS One, 8 e58334 (2013) [C1]
DOI10.1371/journal.pone.0058334Author URL
Co-authorsRick Thorne, Dirk Vanhelden
2013Cannell MB, Kong CHT, Imtiaz MS, Laver DR, 'Control of Sarcoplasmic Reticulum Ca2+ Release by Stochastic RyR Gating within a 3D Model of the Cardiac Dyad and Importance of Induction Decay for CICR Termination', BIOPHYSICAL JOURNAL, 104 2149-2159 (2013) [C1]
DOI10.1016/j.bpj.2013.03.058Author URL
CitationsScopus - 14Web of Science - 14
2013Laver DR, Kong CHT, Imtiaz MS, Cannell MB, 'Termination of calcium-induced calcium release by induction decay: An emergent property of stochastic channel gating and molecular scale architecture', JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 54 98-100 (2013) [C1]
DOI10.1016/j.yjmcc.2012.10.009Author URL
CitationsScopus - 19Web of Science - 16
2013Kong CHT, Laver DR, Cannell MB, 'Extraction of Sub-microscopic Ca Fluxes from Blurred and Noisy Fluorescent Indicator Images with a Detailed Model Fitting Approach', PLOS COMPUTATIONAL BIOLOGY, 9 (2013) [C1]
DOI10.1371/journal.pcbi.1002931Author URL
CitationsScopus - 5Web of Science - 4
2012Seymour VAL, Curmi JP, Howitt SM, Casarotto MG, Laver DR, Tierney ML, 'Selective modulation of different GABA A receptor isoforms by diazepam and etomidate in hippocampal neurons', International Journal of Biochemistry and Cell Biology, 44 1491-1500 (2012) [C1]
CitationsScopus - 3Web of Science - 2
2011Hwang HS, Hasdemir C, Laver DR, Mehra DR, Turhan K, Faggioni M, et al., 'Inhibition of Cardiac Ca2+ Release Channels (RyR2) Determines Efficacy of Class I Antiarrhythmic Drugs in Catecholaminergic Polymorphic Ventricular Tachycardia', Circulation: Arrhythmia and Electrophysiology, 4 128-135 (2011) [C1]
CitationsScopus - 51Web of Science - 39
2011Laver DR, Van Helden DF, 'Three independent mechanisms contribute to tetracaine inhibition of cardiac calcium release channels', Journal of Molecular and Cellular Cardiology, 51 357-369 (2011) [C1]
DOI10.1016/j.yjmcc.2011.05.009
CitationsScopus - 5Web of Science - 6
Co-authorsDirk Vanhelden
2010Hwang HS, Hasdemir C, Laver D, Mehra D, Turhan K, Faggioni M, et al., 'Inhibition of Cardiac Ca2+ Release Channels (RyR2) Determines Efficacy of Class I Antiarrhythmic Drugs in Catecholaminergic Polymorphic Ventricular Tachycardia', CIRCULATION, 122 (2010) [C3]
Author URL
2010Imtiaz MS, Von Der Weid P-Y, Laver DR, Van Helden DF, 'SR Ca2+ store refill-a key factor in cardiac pacemaking', Journal of Molecular and Cellular Cardiology, 49 412-426 (2010) [C1]
DOI10.1016/j.yjmcc.2010.03.015
CitationsScopus - 9Web of Science - 7
Co-authorsDirk Vanhelden
2010Hilliard FA, Steele DS, Laver DR, Yang Z, Le Marchand SJ, Chopra N, et al., 'Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass', Journal of Molecular and Cellular Cardiology, 48 293-301 (2010) [C1]
DOI10.1016/j.yjmcc.2009.10.005
CitationsScopus - 101Web of Science - 84
2010Shtifman A, Ward CW, Laver DR, Bannister ML, Lopez JR, Kitazawa M, et al., 'Amyloid-ß protein impairs Ca2+ release and contractility in skeletal muscle', Neurobiology of Aging, 31 2080-2090 (2010) [C1]
DOI10.1016/j.neurobiolaging.2008.11.003
CitationsScopus - 16Web of Science - 12
2010Van Helden DF, Laver DR, Holdsworth JL, Imtiaz MS, 'Generation and propagation of gastric slow waves', Clinical and Experimental Pharmacology and Physiology, 37 516-524 (2010) [C1]
DOI10.1111/j.1440-1681.2009.05331.x
CitationsScopus - 20Web of Science - 17
Co-authorsDirk Vanhelden, John Holdsworth
2009Laver D, 'Chapter 4 Electrical Methods for Determining Surface Charge Density and Electrolyte Composition at the Lipid Bilayer-Solution Interface', Advances in Planar Lipid Bilayers and Liposomes, 9 87-105 (2009)

In this chapter I will review electrical methods for inferring the surface potential and surface charge density on lipid bilayers and the electrolyte composition at the bilayer interface. I will review the early studies which measured electrostatic potentials between the bilayer interior and the external solution. These include methods based on ionophores, open circuit potential measurements, the inner field compensation and measurements of the ionic double-layer capacitance. I will then go on to review two methods which I developed for inferring changes in solute concentrations (solution transients) at a bilayer surface during solution changes which also allows simultaneous measurement of single channel activity. These methods (1) use fast solution changes with induce a shift in bilayer potential that can generate a transient, capacitive current through the bilayer under voltage-clamp conditions and (2) use ion channels embedded in the bilayer to sense solute concentrations during solution exchange. © 2009 Elsevier Inc. All rights reserved.

DOI10.1016/S1554-4516(09)09004-8
2009Chopra N, Laver DR, Davies SS, Knollmann BC, 'Amitriptyline activates cardiac ryanodine channels and causes spontaneous sarcoplasmic reticulum calcium release', Molecular Pharmacology, 75 183-195 (2009) [C1]
DOI10.1124/mol.108.051490
CitationsScopus - 15Web of Science - 15
2009Laver DR, 'Luminal Ca2+ activation of cardiac ryanodine receptors by luminal and cytoplasmic domains', European Biophysics Journal, 39 19-26 (2009) [C1]
DOI10.1007/s00249-009-0417-1
CitationsScopus - 19Web of Science - 18
2009Everitt AB, Seymour VAL, Curmi J, Laver DR, Gage PW, Tierney ML, 'Protein interactions involving the gamma 2 large cytoplasmic loop of GABA(A) receptors modulate conductance', FASEB Journal, 23 4361-4369 (2009) [C1]
DOI10.1096/fj.09-137042
CitationsScopus - 10Web of Science - 10
2009Watanabe H, Chopra N, Laver DR, Hwang HS, Davies SS, Roach DE, et al., 'Flecainide prevents catecholaminergic polymorphic ventricular tachycardia in mice and humans', Nature Medicine, 15 380-383 (2009) [C1]
DOI10.1038/nm.1942
CitationsScopus - 242Web of Science - 192
2008Laver DR, Honen BN, 'Luminal Mg2+, a key factor controlling RYR2-mediated Ca2+ release: Cytoplasmic and luminal regulation modeled in a tetrameric channel', Journal of General Physiology, 132 429-446 (2008) [C1]
DOI10.1085/jgp.200810001
CitationsScopus - 24Web of Science - 25
2008Laver DR, Honen BN, Lamb GD, Ikemoto N, 'A domain peptide of the cardiac ryanodine receptor regulates channel sensitivity to luminal Ca2+ via cytoplasmic Ca2+ sites', European Biophysics Journal with Biophysics Letters, 37 455-467 (2008) [C1]
DOI10.1007/s00249-007-0238-z
CitationsScopus - 7Web of Science - 7
2007Laver DR, 'Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sites', Clinical and Experimental Pharmacology and Physiology, 34 889-896 (2007) [C1]
DOI10.1111/j.1440-1681.2007.04708.x
CitationsScopus - 35Web of Science - 38
2007Laver DR, 'Ca2+ stores regulate ryanodine receptor Ca2+ release channels via luminal and cytosolic Ca2+ sites', Biophysical Journal, 92 3541-3555 (2007) [C1]
DOI10.1529/biophysj.106.099028
CitationsScopus - 62Web of Science - 64
2007Laver DR, Hamada T, Fessenden JD, Ikemoto N, 'The ryanodine receptor pore blocker neomycin also inhibits channel activity via a previously undescribed high-affinity Ca2+ binding site', Journal of Membrane Biology, 220 11-20 (2007) [C1]
DOI10.1007/s00232-007-9067-3
CitationsScopus - 5Web of Science - 5
2006Laver DR, 'Regulation of ryanodine receptors from skeletal and cardiac muscle during rest and excitation', Clinical and Experimental Pharmacology & Physiology, 33 1107-1113 (2006) [C1]
DOI10.1111/j.1440-1681.2006.04500.x
CitationsScopus - 10Web of Science - 10
2006Laver DR, Bradley KM, 'Disulfonic stilbene permeation and block of the anion channel from the sarcoplasmic reticulum of rabbit skeletal muscle', American Journal of Physiology-Cell Physiology, 290 C1666-C1677 (2006) [C1]
DOI10.1152/ajpcell.00299.2005
CitationsScopus - 7Web of Science - 6
2006Lindquist CEL, Laver DR, Birnir B, 'The mechanism of SR95531 inhibition at GABA(A) receptors examined in human alpha(1)beta(1) and alpha(1)beta(1)gamma(2S) receptors (vol 94, pg 491, 2005) (Errartum)', Journal of Neurochemistry, 97 302-302 (2006) [C3]
DOI10.1111/j.1471-4159.2005.03240.x
CitationsScopus - 8Web of Science - 8
2005Haarmann CS, Dulhunty AF, Laver DR, 'Regulation of skeletal ryanodine receptors by dihydropyridine receptor II-III loop C-region peptides: relief of Mg2+ inhibition', Biochemical Journal, 387 429-436 (2005) [C1]
DOI10.1042/BJ20040786
CitationsScopus - 12Web of Science - 12
2005Laver DR, 'Coupled calcium release channels and their regulation by luminal and cytosolic ions', European Biophysics Journal with Biophysics Letters, 34 359-368 (2005) [C1]
DOI10.1007/s00249-005-0483-y
CitationsScopus - 20Web of Science - 19
2005Lindquist CEL, Laver DR, Birnir B, 'The mechanism of SR95531 inhibition at GABA(A) receptors examined in human alpha(1)beta(1) and alpha(1)beta(1)gamma(2S) receptors', Journal of Neurochemistry, 94 491-501 (2005) [C1]
2005Beard NA, Casarotto MG, Wei L, Varsanyi M, Laver DR, Dulhunty AF, 'Regulation of ryanodine receptors by calsequestrin: Effect of high luminal Ca2+ and phosphorylation', Biophysical Journal, 88 3444-3454 (2005) [C1]
DOI10.1529/biophysj.104.051441
CitationsScopus - 66Web of Science - 61
2004Laver DR, O'Neill ER, Lamb GD, 'Luminal Ca2+ - regulated Mg2+ inhibition of skeletal RyRs reconstituted as isolated channels or coupled clusters', J Gen Physiol, 124 741-758 (2004) [C1]
DOI10.1085/jgp.200409092
CitationsScopus - 50Web of Science - 51
2004Beard NA, Laver DR, Dulhunty AF, 'Calsequestrin and the calcium release challen of skeletal and cardiac muscle', Progress in Biophysics & Molecular Biology, 85 33-69 (2004) [C1]
DOI10.1016/j.pbiomolbio.2003.07.001
CitationsScopus - 154Web of Science - 145
2003O'Neill ER, Sakowska MM, Laver DR, 'Regulation of the Calcium Release Channel from Skeletal Muscle by Suramin and the Disulfonated Stilbene Derivatives DIDS, DBDS, and DNDS', Biophysical Journal, 84 1674-1689 (2003) [C1]
DOI10.1016/S0006-3495(03)74976-5
CitationsScopus - 23Web of Science - 22
2003Honen BN, Saint DA, Laver DR, 'Supression of Calcium Sparks in Rat Ventricular Myocytes and Direct Inhitition of Sheep Cardiac RyR Channels by EPA, DHA and Oleic Acid', Journal of Membrane Biology, 196 95-103 (2003) [C1]
DOI10.1007/s00232-003-0628-9
CitationsScopus - 41Web of Science - 37
2003Haarmann C, Green D, Casarotto MG, Laver DR, Dalhunty AF, 'The Random-Coil 'C' fragment of the dihydropyridine receptor II-III loop can activate or inhibit native skeletal ryanodine receptors', Biochemical journal, 375 305-316 (2003) [C1]
DOI10.1042/BJ20021763
CitationsScopus - 30Web of Science - 31
2002Dulhunty AF, Haarmann CS, Green D, Laver DR, Board PG, Casarotto MG, 'Interactions between dihydropyridine receptors and ryanodine receptors in striated muscle', PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 79 45-75 (2002)
DOI10.1016/S0079-6107(02)00013-5Author URL
CitationsScopus - 55Web of Science - 60
2002Beard NA, Sakowska MM, Dulhunty AF, Laver DR, 'Calsequestrin is an Inhibitor of Skeletal Muscle Ryanodine Receptor Calcium Release Channels', Biophysical Journal, 82 310-320 (2002) [C1]
CitationsWeb of Science - 87
2001Dulhunty AF, Laver D, Curtis SM, Pace S, Haarmann C, Gallant EM, 'Characteristics of irreversible ATP activation suggest that native skeletal ryanodine receptors can be phosphorylated via an endogenous CaMKII', BIOPHYSICAL JOURNAL, 81 3240-3252 (2001)
Author URL
CitationsWeb of Science - 37
2001Laver DR, Lenz GKE, Dulhunty AF, 'Phosphate ion channels in sarcoplasmic reticulum of rabbit skeletal muscle', JOURNAL OF PHYSIOLOGY-LONDON, 535 715-728 (2001)
DOI10.1111/j.1469-7793.2001.t01-1-00715.xAuthor URL
CitationsWeb of Science - 17
2001Laver DR, Lenz GKE, Lamb GD, 'Regulation of the calcium release channel from rabbit skeletal muscle by the nucleotides ATP, AMP, IMP and adenosine', JOURNAL OF PHYSIOLOGY-LONDON, 537 763-778 (2001)
Author URL
CitationsWeb of Science - 38
2001Laver DR, 'The power of single channel recording and analysis: Its application to ryanodine receptors in lipid bilayers', CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 28 675-686 (2001)
DOI10.1046/j.1440-1681.2001.03503.xAuthor URL
CitationsWeb of Science - 9
2000Laver DR, Eager KR, Taoube L, Lamb GD, 'Effects of cytoplasmic and luminal pH on Ca2+ release channels from rabbit skeletal muscle', BIOPHYSICAL JOURNAL, 78 1835-1851 (2000)
Author URL
CitationsWeb of Science - 21
2000Lamb GD, Laver DR, Stephenson DG, 'Perspective - Questions about adaptation in ryanodine receptors', JOURNAL OF GENERAL PHYSIOLOGY, 116 883-890 (2000)
DOI10.1085/jgp.116.6.883Author URL
CitationsWeb of Science - 11
2000Panter S, Thomson R, de Bruxelles G, Laver D, Trevaskis B, Udvardi M, 'Identification with proteomics of novel proteins associated with the peribacteroid membrane of soybean root nodules', MOLECULAR PLANT-MICROBE INTERACTIONS, 13 325-333 (2000)
DOI10.1094/MPMI.2000.13.3.325Author URL
CitationsWeb of Science - 86
1999Dulhunty AF, Laver DR, Gallant EM, Casarotto MG, Pace SM, Curtis S, 'Activation and inhibition of skeletal RyR channels by a part of the skeletal DHPR II-III loop: Effects of DHPR Ser(687) and FKBP12', BIOPHYSICAL JOURNAL, 77 189-203 (1999)
DOI10.1016/S0006-3495(99)76881-5Author URL
CitationsWeb of Science - 71
1998Ahern GP, Laver DR, 'ATP inhibition and rectification of a Ca2+-activated anion channel in sarcoplasmic reticulum of skeletal muscle', BIOPHYSICAL JOURNAL, 74 2335-2351 (1998)
Author URL
CitationsWeb of Science - 22
1998Laver DR, Lamb GD, 'Inactivation of Ca2+ release channels (ryanodine receptors RyR1 and RyR2) with rapid steps in [Ca2+] and voltage', BIOPHYSICAL JOURNAL, 74 2352-2364 (1998)
Author URL
CitationsWeb of Science - 47
1997Laver DR, Owen VJ, Junankar PR, Taske NL, Dulhunty AF, Lamb GD, 'Reduced inhibitory effect of Mg2+ on ryanodine receptor Ca2+ release channels in malignant hyperthermia', BIOPHYSICAL JOURNAL, 73 1913-1924 (1997)
Author URL
CitationsWeb of Science - 76
1997Laver DR, Owen VJ, Junankar PR, Taske NL, Dulhunty AF, Lamb GD, 'Ca2+- and Mg2+-Regulation of Calcium Release Channels from Normal and Malignant Hyperthermia Susceptible Pigs', Biophysical Journal, 73 1913-1924 (1997) [C1]
1997McCulloch SR, Laver DR, Walker NA, 'Anion channel activity in the Chara plasma membrane: Co-operative subunit phenomena and a model', JOURNAL OF EXPERIMENTAL BOTANY, 48 383-397 (1997)
DOI10.1093/jxb/48.Special_Issue.383Author URL
CitationsWeb of Science - 8
1997Laver DR, Cherry CA, Walker NA, 'The actions of calmodulin antagonists W-7 and TFP and of calcium on the gating kinetics of the calcium-activated large conductance potassium channel of the Chara protoplasmic drop: A substate-sensitive analysis', JOURNAL OF MEMBRANE BIOLOGY, 155 263-274 (1997)
DOI10.1007/s002329900179Author URL
CitationsWeb of Science - 15
1997Laver DR, Baynes TM, Dulhunty AF, 'Magnesium inhibition of ryanodine-receptor calcium channels: Evidence for two independent mechanisms', JOURNAL OF MEMBRANE BIOLOGY, 156 213-229 (1997)
DOI10.1007/s002329900202Author URL
CitationsWeb of Science - 147
1997Laver DR, Gage PW, 'Interpretation of substates in ion channels: Unipores or multipores?', PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY, 67 99-140 (1997)
DOI10.1016/S0079-6107(97)00008-4Author URL
CitationsWeb of Science - 19
1996Dulhunty AF, Junankar PR, Eager KR, Ahern GP, Laver DR, 'Ion channels in the sarcoplasmic reticulum of striated muscle', ACTA PHYSIOLOGICA SCANDINAVICA, 156 375-385 (1996)
DOI10.1046/j.1365-201X.1996.193000.xAuthor URL
CitationsWeb of Science - 22
1996Kourie JI, Laver DR, Junankar PR, Gage PW, Dulhunty AF, 'Characteristics of two types of chloride channel in sarcoplasmic reticulum vesicles from rabbit skeletal muscle', BIOPHYSICAL JOURNAL, 70 202-221 (1996)
Author URL
CitationsWeb of Science - 57
1996Laver D, Curtis B, 'Rapid solution change activates ryanodine receptors within 20 ms.', BIOPHYSICAL JOURNAL, 70 WPO48-WPO48 (1996)
Author URL
1996Laver DR, Curtis BA, 'Surface potentials measure ion concentrations near lipid bilayers during rapid solution changes', BIOPHYSICAL JOURNAL, 71 722-731 (1996)
Author URL
CitationsWeb of Science - 9
1996Laver DR, Curtis BA, 'Response of ryanodine receptor channels to Ca2+ steps produced by rapid solution', BIOPHYSICAL JOURNAL, 71 732-741 (1996)
Author URL
CitationsWeb of Science - 31
1996Kourie JI, Laver DR, Ahern GP, Dulhunty AF, 'A calcium-activated chloride channel in sarcoplasmic reticulum vesicles from rabbit skeletal muscle', AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 270 C1675-C1686 (1996)
Author URL
CitationsWeb of Science - 30
1995Laver DR, Roden LD, Ahem GP, Eager KR, Junankar PR, Dulhunty AF, 'Cytoplasmic Ca2+ Inhibits the Ryanodine Receptor from Cardiac Muscle', Journal of Membrane Biology, 147 7-22 (1995) [C1]
CitationsWeb of Science - 124
1994LAVER DR, 'THE BARREL-STAVE MODEL AS APPLIED TO ALAMETHICIN AND ITS ANALOGS REEVALUATED', BIOPHYSICAL JOURNAL, 66 355-359 (1994)
Author URL
CitationsWeb of Science - 21
1994LAVER DR, FAIRLEYGRENOT KA, 'SURFACE-POTENTIALS NEAR THE MOUTH OF THE LARGE-CONDUCTANCE K+ CHANNEL FROM CHARA-AUSTRALIS - A NEW METHOD OF TESTING FOR DIFFUSION-LIMITED ION FLOW', JOURNAL OF MEMBRANE BIOLOGY, 139 149-165 (1994)
Author URL
CitationsWeb of Science - 10
1992LAVER DR, 'DIVALENT-CATION BLOCK AND COMPETITION BETWEEN DIVALENT AND MONOVALENT CATIONS IN THE LARGE-CONDUCTANCE K+ CHANNEL FROM CHARA-AUSTRALIS', JOURNAL OF GENERAL PHYSIOLOGY, 100 269-300 (1992)
DOI10.1085/jgp.100.2.269Author URL
CitationsWeb of Science - 22
1991LAVER DR, WALKER NA, 'ACTIVATION BY CA2+ AND BLOCK BY DIVALENT IONS OF THE K+-CHANNEL IN THE MEMBRANE OF CYTOPLASMIC DROPS FROM CHARA-AUSTRALIS', JOURNAL OF MEMBRANE BIOLOGY, 120 131-139 (1991)
DOI10.1007/BF01872396Author URL
CitationsWeb of Science - 31
1991FAIRLEY K, LAVER D, WALKER NA, 'WHOLE-CELL AND SINGLE-CHANNEL CURRENTS ACROSS THE PLASMALEMMA OF CORN SHOOT SUSPENSION CELLS', JOURNAL OF MEMBRANE BIOLOGY, 121 11-22 (1991)
DOI10.1007/BF01870647Author URL
CitationsWeb of Science - 29
1991LAVER DR, 'A SURGICAL METHOD FOR ACCESSING THE PLASMAMEMBRANE OF CHARA-AUSTRALIS', PROTOPLASMA, 161 79-84 (1991)
DOI10.1007/BF01322720Author URL
CitationsWeb of Science - 22
1990LAVER DR, 'COUPLING OF K+-GATING AND PERMEATION WITH CA-2+ BLOCK IN THE CA-2+-ACTIVATED K+ CHANNEL IN CHARA-AUSTRALIS', JOURNAL OF MEMBRANE BIOLOGY, 118 55-67 (1990)
DOI10.1007/BF01872204Author URL
CitationsWeb of Science - 24
1990GENTLE IR, LAVER DR, RITCHIE GLD, 'TEMPERATURE AND PRESSURE-DEPENDENCE OF THE ELECTROOPTICAL KERR EFFECT OF SULFUR-DIOXIDE', JOURNAL OF PHYSICAL CHEMISTRY, 94 3434-3437 (1990)
DOI10.1021/j100372a016Author URL
CitationsWeb of Science - 16
1989LAVER DR, FAIRLEY KA, WALKER NA, 'ION PERMEATION IN A K+ CHANNEL IN CHARA-AUSTRALIS - DIRECT EVIDENCE FOR DIFFUSION LIMITATION OF ION FLOW IN A MAXI-K CHANNEL', JOURNAL OF MEMBRANE BIOLOGY, 108 153-164 (1989)
DOI10.1007/BF01871026Author URL
CitationsWeb of Science - 29
1989CRAVEN IE, HESLING MR, LAVER DR, LUKINS PB, RITCHIE GLD, VRBANCICH J, 'POLARIZABILITY ANISOTROPY, MAGNETIC-ANISOTROPY, AND QUADRUPOLE-MOMENT OF CYCLOHEXANE', JOURNAL OF PHYSICAL CHEMISTRY, 93 627-631 (1989)
DOI10.1021/j100339a026Author URL
CitationsWeb of Science - 40
1989GENTLE IR, LAVER DR, RITCHIE GLD, '2ND HYPERPOLARIZABILITY AND STATIC POLARIZABILITY ANISOTROPY OF CARBON-DIOXIDE', JOURNAL OF PHYSICAL CHEMISTRY, 93 3035-3038 (1989)
DOI10.1021/j100345a033Author URL
CitationsWeb of Science - 21
1987LAVER DR, WALKER NA, 'STEADY-STATE VOLTAG-DEPENDENT GATING AND CONDUCTION KINETICS OF SINGLE K+ CHANNELS IN THE MEMBRANE OF CYTOPLASMIC DROPS OF CHARA-AUSTRALIS', JOURNAL OF MEMBRANE BIOLOGY, 100 31-42 (1987)
DOI10.1007/BF02209138Author URL
CitationsWeb of Science - 42
1986COSTER HGL, LAVER DR, 'THE EFFECT OF TEMPERATURE ON LIPID NORMAL-ALKANE INTERACTIONS IN LIPID BILAYERS', BIOCHIMICA ET BIOPHYSICA ACTA, 857 95-104 (1986)
DOI10.1016/0005-2736(86)90102-1Author URL
CitationsWeb of Science - 10
1986COSTER HGL, LAVER DR, 'THE EFFECT OF BENZYL ALCOHOL AND CHOLESTEROL ON THE ACYL CHAIN ORDER AND ALKANE SOLUBILITY OF BIMOLECULAR PHOSPHATIDYLCHOLINE MEMBRANES', BIOCHIMICA ET BIOPHYSICA ACTA, 861 406-412 (1986)
DOI10.1016/0005-2736(86)90448-7Author URL
CitationsWeb of Science - 18
1985SMITH J, COSTER HGL, LAVER DR, 'THE DEPENDENCE OF THE CONDUCTANCE OF PHOSPHATIDYLCHOLINE BILAYERS UPON THE CONCENTRATION AND COMPOSITION OF THE EXTERNAL ELECTROLYTE', BIOCHIMICA ET BIOPHYSICA ACTA, 812 181-192 (1985)
DOI10.1016/0005-2736(85)90537-1Author URL
CitationsWeb of Science - 16
1985LUKINS PB, LAVER DR, BUCKINGHAM AD, RITCHIE GLD, 'COTTON-MOUTON EFFECT, MAGNETIC-ANISOTROPY, AND CHARGE-DISTRIBUTION OF CYCLOPROPANE', JOURNAL OF PHYSICAL CHEMISTRY, 89 1309-1312 (1985)
DOI10.1021/j100253a050Author URL
CitationsWeb of Science - 29
1984LAVER DR, SMITH J, COSTER HGL, 'THE THICKNESS OF THE HYDROPHOBIC AND POLAR-REGIONS OF GLYCEROL MONOOLEATE BILAYERS DETERMINED FROM THE FREQUENCY-DEPENDENCE OF BILAYER CAPACITANCE', BIOCHIMICA ET BIOPHYSICA ACTA, 772 1-9 (1984)
DOI10.1016/0005-2736(84)90511-XAuthor URL
CitationsWeb of Science - 25
1984SMITH J, LAVER DR, COSTER HGL, 'THE CONDUCTANCE OF LECITHIN BILAYERS - THE DEPENDENCE UPON TEMPERATURE', CHEMISTRY AND PHYSICS OF LIPIDS, 34 227-236 (1984)
DOI10.1016/0009-3084(84)90057-4Author URL
CitationsWeb of Science - 30
1983ASHCROFT RG, COSTER HGL, LAVER DR, SMITH J, 'THE EFFECTS OF CHOLESTEROL INCLUSION ON THE MOLECULAR-ORGANIZATION OF BIMOLECULAR LIPID-MEMBRANES', BIOCHIMICA ET BIOPHYSICA ACTA, 730 231-238 (1983)
DOI10.1016/0005-2736(83)90338-3Author URL
CitationsWeb of Science - 52
1982COSTER HGL, LAVER DR, SCHOENBORN BP, 'EFFECT OF 2H2O/H2O REPLACEMENT ON THE DIELECTRIC STRUCTURE OF LIPID BILAYER-MEMBRANES', BIOCHIMICA ET BIOPHYSICA ACTA, 686 141-143 (1982)
DOI10.1016/0005-2736(82)90161-4Author URL
CitationsWeb of Science - 7
Show 85 more journal articles

Conference (33 outputs)

YearCitationAltmetricsLink
2014Laver DR, Cannell MB, Imtiaz MS, 'Anti-Arrhythmic Block of Ryr2 by Flecainide Versus Pro-Arrhythmic Block by Tetracaine in a 3D Model of a Cardiac Cell', BIOPHYSICAL JOURNAL, San Francisco, CA (2014) [E3]
Author URL
2014Walweel KD, vanHelden DF, Imtiaz MS, Dos Remedios C, Molenaar P, Laver DR, 'Inhibition of RyR2 from Failing and Non-Failing Human Hearts by Calmodulin', BIOPHYSICAL JOURNAL, San Francisco, CA (2014) [E3]
Author URL
Co-authorsDirk Vanhelden
2014Cannell MB, Kong CHT, Laver DR, 'Ryanodine receptor cluster organisation and consequences for EC coupling', CARDIOVASCULAR RESEARCH, Barcelona, SPAIN (2014) [E3]
DOI10.1093/cvr/cvu091.74Author URL
2013Laver DR, Kong CHT, Imtiaz MS, Cannell MB, 'Termination of Calcium Sparks: An Emergent Property from Stochastic RyR Gating and Dyad Geometry', BIOPHYSICAL JOURNAL, Philadelphia, PA (2013) [E3]
Author URL
2013Van Heiden DF, Laver DR, Imtiaz MS, Hashitani H, 'Cellular Interactions Controlling Tonic and Peristaltic Contractions of Gastric Smooth Muscle', JOURNAL OF PHYSIOLOGICAL SCIENCES (2013) [E3]
Author URL
Co-authorsDirk Vanhelden
2012Imtiaz MS, Van Helden DF, Laver DR, 'Three-dimensional modeling of Ca2+ dynamics in single cardiac cells', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
Co-authorsDirk Vanhelden
2012Imtiaz MS, Allen DG, Van Helden DF, Laver DR, 'Role of intracellular Ca2+ in sinoatrial node pacemaking', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
Co-authorsDirk Vanhelden
2012Mehra DR, Van Helden DF, Laver DR, 'Role of cardiac Na+ channel blockers and Mg2+ in inhibiting the cardiac calcium release channel', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
Co-authorsDirk Vanhelden
2012Walweel K, Beard NA, Li J, Van Helden DF, Imtiaz MS, Molenaar P, Laver DR, 'Regulation of human RYR2 by intracellular Ca2+ and Mg2+', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
Co-authorsDirk Vanhelden
2012Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne RF, Van Helden DF, Laver DR, 'Adrenergic stimulation increases RYR2 activity via intracellular Ca2+ and Mg2+ regulation', Sydney 2012 Joint AuPS/PSNZ/ASB Meeting. Programme, Sydney, NSW (2012) [E3]
CitationsScopus - 6Web of Science - 6
Co-authorsDirk Vanhelden, Rick Thorne
2012Li J, Imtiaz MS, Beard NA, Dulhunty AF, Thorne RF, Van Helden DF, Laver DR, 'Adrenergic stimulation alters RyR2 regulation by Ca2+ and Mg2+', Heart, Lung and Circulation: Abstracts of ISHR Auckland Workshop, Auckland, NZ (2012) [E3]
Co-authorsRick Thorne, Dirk Vanhelden
2011Walweel K, Li J, Van Helden DF, Imtiaz MS, Molenaar P, Laver DR, 'Regulation of RyRs by intracellular Ca2+ and Mg2+ compared in sheep, rat and human heart', Proceedings of the Australian Physiological Society 2011, Perth (2011) [E3]
Co-authorsDirk Vanhelden
2011Mehra DR, Van Helden DF, Hwang HS, Knollmann B, Laver DR, 'Role of cardiac Na+ channel blockers in inhibiting the cardiac calcium release channel', Proceedings of the Australian Physiological Society 2011, Perth (2011) [E3]
Co-authorsDirk Vanhelden
2011Morris D, Saint D, Laver DR, 'Negative inotropic effect of riluzole: Blockade of the ryanadine receptor?', Heart, Lung and Circulation, Perth, WA (2011) [E3]
2009Hollins SL, Johnstone DM, Graham R, Van Helden DF, Kerr KP, Laver DR, et al., 'Cardiac gene expression in mouse models of iron loading disorders', 2009 International Biolron Society Meeting: Program Book, Porto, Portugal (2009) [E3]
Co-authorsRodney Scott, Liz Milward, Dirk Vanhelden, Karen Kerr
2009Mehra DR, Van Helden DF, Knollmann B, Laver DR, 'Flecainide inhibits CPVT induced cardiac arrhythmias by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass', 33rd Annual Meeting of the Australian Society for Biophysics: Program, Ballarat, VIC (2009) [E3]
Co-authorsDirk Vanhelden
2009Hollins SL, Johnstone DM, Van Helden DF, Kerr KP, Laver DR, Metelerkamp KM, et al., 'Cardiac gene expression in mouse models of iron loading', ASMR XVII NSW Scientific Meeting: Programme and Abstracts, Sydney, NSW (2009) [E3]
Co-authorsDirk Vanhelden, Rodney Scott, Liz Milward, Karen Kerr
2009Laver DR, Quail AW, Sitsapesan H, Van Helden DF, 'The effect of volatile anaesthetics on the cardiac ryanodine receptor', Biophysical Journal, Boston, MA (2009) [E3]
Co-authorsDirk Vanhelden, Tony Quail
2009Hilliard FA, Laver DR, Le Marchand SJ, Piston DW, Knollmann BG, 'Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass', Circulation, Orlando, FL (2009) [E3]
2008Laver DR, Quail AW, Sitsapesan H, Van Helden DF, 'Effect of volatile anaesthetics on the calcium release channel in the heart', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]
Co-authorsDirk Vanhelden, Tony Quail
2008Van Helden DF, Laver DR, Imtiaz MS, 'Ca2+ phase waves: A fundamental mechanism underlying propagation of gastric slow waves', Proceedings of the Australian Physiological Society, Melbourne, VIC (2008) [E3]
Co-authorsDirk Vanhelden
2008Chopra N, Watanabe H, Laver DR, Hwang HS, Roden DM, Knollmann BC, 'Flecainide blocks cardiac ryanodine channels and prevents catecholaminergic ventricular tachycardia in cardiac calsequestrin null mice', Circulation, - (2008) [E3]
2007Tierney ML, Everitt AB, Seymour VAL, Laver DR, 'Subunit-specific interactions between gabaa receptors underlie diazepam modulated high conductance gaba channels (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
2007Chopra N, Laver DR, Watanabe H, Nair UB, Stein CM, Knollmann BC, 'Amitriptyline activates cardiac ryanodine receptors independently of its action on cardiac calsequestrin: Role for amitriptyline linked sudden cardiac death', Circulation, Orlando, FL. (2007) [E3]
2007Laver DR, 'Store activation mechanism for cardiac ryanodine receptors', BIOPHYSICAL JOURNAL, Baltimore, MD (2007)
Author URL
2005Honen BN, Lamb GD, Laver DR, Ikemoto N, 'Aberrant calcium release underlying sudden cardiac death probed with RyR domain peptides', BIOPHYSICAL JOURNAL, Long Beach, CA (2005)
Author URL
2005Laver DR, Lamb GD, 'Regulation of single and coupled RyRs in bilayers by luminal Ca2+', BIOPHYSICAL JOURNAL, Long Beach, CA (2005)
Author URL
2005Honen BN, Dalton RL, Van Helden DF, Laver DR, 'Acute application of n-3 polyunsaturated fatty acids modify calcium sparks in permeabilised rat cardiac myocytes', Proceedings of the Australian Physiological Society, Canberra (2005) [E3]
Co-authorsDirk Vanhelden
2005Laver DR, 'Regulation of ryanodine receptors from skeletal and cardiac muscle by components of the cytoplasm and lumen', Proceedings of the Australian Physiological Society, Canberra (2005) [E3]
2004Honen BN, Saint DA, Van Helden DF, Laver DR, 'The effects of fatty acids on SR calcium release channels from cardiac muscle', Biophysical Journal, Maryland, USA (2004) [E3]
Co-authorsDirk Vanhelden
2004Haarmann CS, Dulhunty AF, Laver DR, 'The manifold effects of peptide C region of the DHPR II-III loop on RyRs', Biophysical Journal, Maryland, USA (2004) [E3]
2003O'Neill E, Lamb G, Laver D, 'Magnesium inhibition of skeletal RyRs modified by DIDS, ryanodine and ATP', BIOPHYSICAL JOURNAL, SAN ANTONIO, TEXAS (2003)
Author URL
2003Kobayashi S, Yamamoto T, Laver DR, Lamb GD, Ikemoto N, 'RyR1 and RyR2 seem to share a common mechanism of cytoplasmic domain-mediated channel regulation: peptide probe studies', BIOPHYSICAL JOURNAL, SAN ANTONIO, TEXAS (2003)
Author URL
Show 30 more conferences
Edit

Grants and Funding

Summary

Number of grants38
Total funding$3,245,011

Click on a grant title below to expand the full details for that specific grant.


20152 grants / $607,103

Regulation of RyR2 channels by calmodulin in healthy and diseased hearts$605,103

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Bjorn Knollman
SchemeProject Grant
RoleLead
Funding Start2015
Funding Finish2015
GNoG1400064
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Biophysical Society 59th Annual Meeting, Maryland USA, 7-11 Feb 2015$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamAssociate Professor Derek Laver
SchemeTravel Grant
RoleLead
Funding Start2015
Funding Finish2016
GNoG1500429
Type Of FundingInternal
CategoryINTE
UONY

20141 grants / $1,728

Biophysical Society 58th Annual Meeting, San Fransisco USA, 15-19 February 2014$1,728

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamAssociate Professor Derek Laver
SchemeTravel Grant
RoleLead
Funding Start2014
Funding Finish2014
GNoG1400396
Type Of FundingInternal
CategoryINTE
UONY

20132 grants / $12,000

Investigating the basis for diabetes-associated gastric motility disorders$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden, Associate Professor Derek Laver
SchemeNear Miss Grant
RoleInvestigator
Funding Start2013
Funding Finish2013
GNoG1300485
Type Of FundingInternal
CategoryINTE
UONY

Biophysical Society 57th Annual Meeting, Pennsylvania Convention Centre, Philadelphia, 2 - 6 February 2013$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamAssociate Professor Derek Laver
SchemeTravel Grant
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300542
Type Of FundingInternal
CategoryINTE
UONY

20122 grants / $22,000

Gastric Slow Waves and Motility Disorders$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden, Associate Professor Derek Laver
SchemeNear Miss Grant
RoleInvestigator
Funding Start2012
Funding Finish2012
GNoG1200674
Type Of FundingInternal
CategoryINTE
UONY

Gordon Research Conference on Muscle, Les Diablerets Conference Center, Les Diablerets Switzerland, 3 - 8 June 2012$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamAssociate Professor Derek Laver
SchemeTravel Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1200933
Type Of FundingInternal
CategoryINTE
UONY

20112 grants / $538,706

Ryanodine receptor inhibitors as therapy for Ca2+ store overload induced arrhythmias$536,706

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Bjorn Knollman
SchemeProject Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1000274
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Biophysics Society, Baltimore Convention Centre, 5 - 9 March 2011$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding bodyUniversity of Newcastle - Faculty of Health and Medicine
Project TeamAssociate Professor Derek Laver
SchemeTravel Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1100184
Type Of FundingInternal
CategoryINTE
UONY

20105 grants / $528,050

Regulation of calcium release channels (RyR2) in healthy and failing hearts$325,575

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Derek Laver, Dr Nicole Beard, Professor Angela Dulhunty
SchemeProject Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG0190194
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

HMRI MRSP Infrastructure Grant (10-11) - Cardiovascular$76,117

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Eugene Nalivaiko, Associate Professor Liz Milward, Professor Robert Callister, Professor Manohar Garg, Conjoint Professor Tony Quail
SchemeNSW MRSP Infrastructure Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG1100525
Type Of FundingOther Public Sector - State
Category2OPS
UONY

HMRI MRSP Infrastructure Grant 09/10 - Cardiovascular$62,358

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Derek Laver
SchemeNSW MRSP Infrastructure Grant
RoleLead
Funding Start2010
Funding Finish2010
GNoG1000559
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

ABI 7500 Real Time PCR System $34,000

Funding body: NHMRC (National Health & Medical Research Council)

Effective anti-arrhythmic drugs: How do they work?$30,000

Funding body: BellBerry Limited

Funding bodyBellBerry Limited
Project TeamAssociate Professor Derek Laver, Professor Dirk Van Helden, Associate Professor Bjorn Knollman
SchemeNear Miss
RoleLead
Funding Start2010
Funding Finish2010
GNoG0900218
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

20092 grants / $21,175

Propagation and directionality of gastric slow waves$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Dirk Van Helden, Associate Professor Derek Laver
SchemeNear Miss Grant
RoleInvestigator
Funding Start2009
Funding Finish2009
GNoG0189817
Type Of FundingInternal
CategoryINTE
UONY

Gordon Conference on Muscle, New Hampshire, USA, 14-19 June 2009$1,175

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Derek Laver
SchemeTravel Grant
RoleLead
Funding Start2009
Funding Finish2009
GNoG0900243
Type Of FundingInternal
CategoryINTE
UONY

20082 grants / $27,500

The effects of iron status on calcium handling systems in heart and brain$25,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Derek Laver, Associate Professor Liz Milward, Professor Dirk Van Helden, Professor Rodney Scott
SchemeProject Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188463
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Biophysics Society, Long Beach Conference Centre, 2/2/2008 - 6/2/2008$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Derek Laver
SchemeTravel Grant
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188597
Type Of FundingInternal
CategoryINTE
UONY

20076 grants / $594,607

HMRI - Cardiovascular Research Program$518,556

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Derek Laver, Conjoint Professor Tony Quail, Professor Dirk Van Helden, Professor Manohar Garg, Professor Robin Callister
SchemeNSW MRSP Infrastructure Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187946
Type Of FundingOther Public Sector - State
Category2OPS
UONY

High speed/sensitivity CCD camera$30,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamProfessor Dirk Van Helden, Professor Eileen McLaughlin, Professor Gordon Burns, Doctor Rick Thorne, Dr Marcus Howlett, Doctor Mohammad Imtiaz, Professor Alan Brichta, Professor Robert Callister, Doctor Brett Graham, Associate Professor Derek Laver, Associate Professor Liz Milward, Doctor John Holdsworth
SchemeEquipment Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188196
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Magnesium and calcium regulation of calcium release channels in cardiac and skeletal muscle in health and disease$20,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Derek Laver
SchemeNear Miss Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187200
Type Of FundingInternal
CategoryINTE
UONY

3D Imaging Software/Work station$20,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor David Pow, Doctor Chris Dayas, Doctor Phil Jobling, Associate Professor Derek Laver
SchemeEquipment Grant
RoleInvestigator
Funding Start2007
Funding Finish2007
GNoG0188026
Type Of FundingOther Public Sector - State
Category2OPS
UONY

(93) Hunter Medical Research Institute - Cardiovascular$3,551

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Derek Laver
SchemePublication Performance Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187978
Type Of FundingInternal
CategoryINTE
UONY

Biophysics Society, Baltimore Conference Centre, 3/3/2007 - 7/3/2007$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Derek Laver
SchemeTravel Grant
RoleLead
Funding Start2007
Funding Finish2007
GNoG0187324
Type Of FundingInternal
CategoryINTE
UONY

20063 grants / $27,500

Mechanisms of action of w-3 fatty acids in control of atrial arrhythmias $16,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Derek Laver, Professor Dirk Van Helden, Doctor Bonny Honen
SchemeProject Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186102
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

Regulation of calcium release channels by Ca2+ store load and phosphorylation$10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Derek Laver
SchemeNear Miss Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186579
Type Of FundingInternal
CategoryINTE
UONY

Biophysics Society 18-22 Feb 2006$1,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Derek Laver
SchemeTravel Grant
RoleLead
Funding Start2006
Funding Finish2006
GNoG0186562
Type Of FundingInternal
CategoryINTE
UONY

20052 grants / $137,278

Intrinsic properties of the pore forming domain of the Ryanodine Receptor Calcium Channel$135,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamAssociate Professor Derek Laver
SchemeDiscovery Projects
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185058
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

2005 Annual meeting of the Biophysical Society, 12-16 Feb 2005, USA$2,278

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Derek Laver
SchemeTravel Grant
RoleLead
Funding Start2005
Funding Finish2005
GNoG0185126
Type Of FundingInternal
CategoryINTE
UONY

20041 grants / $12,903

Regulation of normal and diseased cardiac Ca+ channels$12,903

Funding body: NIH National Institutes of Health

Funding bodyNIH National Institutes of Health
Project TeamAssociate Professor Derek Laver
SchemeCollaborative NIH Research Grant
RoleLead
Funding Start2004
Funding Finish2004
GNoG0185411
Type Of FundingNot Known
CategoryUNKN
UONY

20034 grants / $190,500

Aberrant behaviour of cardiac calcium release channels induced by ryanodine receptor peptide probes$160,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Derek Laver
SchemeProject Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0183037
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Mechanisms of action of omega-3 fatty acids in reduction of hypertension.$17,000

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamAssociate Professor Derek Laver, Professor Dirk Van Helden
SchemeResearch Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182641
Type Of FundingContract - Aust Non Government
Category3AFC
UONY

C. elegans as an expression system for proteins that govern calcium release from internal stores.$11,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Derek Laver
SchemeProject Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182453
Type Of FundingInternal
CategoryINTE
UONY

Gordon Conference on Muscle Contraction, New London, NH, USA 8 - 13 June, 2003$2,500

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Derek Laver
SchemeTravel Grant
RoleLead
Funding Start2003
Funding Finish2003
GNoG0182761
Type Of FundingInternal
CategoryINTE
UONY

20024 grants / $523,961

Mechanisms governing regulation of ryanodine receptors function.$292,000

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamAssociate Professor Derek Laver
SchemeAustralian Senior Research Fellowship
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181740
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Mechanisms governing regulation of ryanodine receptors function.$110,861

Funding body: ARC (Australian Research Council)

Funding bodyARC (Australian Research Council)
Project TeamAssociate Professor Derek Laver
SchemeLarge Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181739
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Role of calcium stores and phosphate channells in muscular fatigue.$107,100

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Derek Laver
SchemeProject Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0181815
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Dynamic Regulation Mechanisms of IP3-Receptor Calcium Release Channels$14,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamAssociate Professor Derek Laver
SchemeNew Staff Grant
RoleLead
Funding Start2002
Funding Finish2002
GNoG0182022
Type Of FundingInternal
CategoryINTE
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2015Mechanosensitivity of TRPC6 Channels and its Role in Mechanoelectric Feedback of the Heart
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2012Effects of Calmodulin on Function of Cardiac Ryanodine Receptor
Human Biology, Faculty of Health and Medicine
Co-Supervisor
2011The Lymphatic Function in Diabetes
Human Biology, Faculty of Health and Medicine
Co-Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2014Mechanisms of Cardiac Ryanodine Receptor Inhibition by Anti Arrhythmic Drugs
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2014Regulation of Calcium Release Channels (RyR2) in Healthy and Failing Human Hearts
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2013Regulation of Cardiac Calcium Release Channels During Acute Beta-Adrenergic Stimulation
Human Biology, Faculty of Health and Medicine
Principal Supervisor
2006Determinates of GABAA receptor single channel conductance
Biol Sc Not Elsewhere Classifd, Australian National University
Co-Supervisor
2004The effect of poly unstaturated fatty acids on Ca2+ sparks
Biol Sc Not Elsewhere Classifd, University of Newcastle
Co-Supervisor
2002A study of the effect of ryanodine receptor oxidation on its regulation by myoplasmic substances
Biol Sc Not Elsewhere Classifd, Australian National University
Co-Supervisor
2002The effects of protein-protein interactions on the functioning of ryanodine receptors
Biol Sc Not Elsewhere Classifd, Australian National University
Co-Supervisor
1999A study of desensitization in GABAA receptors
Biol Sc Not Elsewhere Classifd, Australian National University
Co-Supervisor
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News

Cardiology Riddle solved in 3D heartbeat

Cardiology riddle solved in 3D heartbeat

June 21, 2013

Using sophisticated computer modelling, a University of Newcastle researcher has helped find the missing piece to a 20-year cardiology puzzle – working out precisely how the heart regulates its beat.

Associate Professor Derek Laver

Position

Associate Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Human Physiology

Contact Details

Emailderek.laver@newcastle.edu.au
Phone(02) 4921 8732
Fax(02) 4921 7406

Office

RoomMS407
BuildingMedical Sciences
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
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