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Dr Susan Hua

Senior Lecturer

School of Biomedical Sciences and Pharmacy (Pharmacy and Experimental Pharmacology)

Career Summary

Biography

Research Expertise
Dr Hua has established the Therapeutic Targeting Research Group at The University of Newcastle. Her background as a clinical pharmacist has given her a thorough clinical understanding of therapeutics and disease states, and has allowed her to identify promising research avenues in therapeutics and drug delivery. The research focus of Dr Hua's laboratory is on targeted drug delivery using nanomedicines in biomedical applications, which forms the basis of a number of her research collaborations. More specifically, her research group is focused on translational pain research in the areas of peripheral analgesia and inflammation in acute and chronic pain conditions - incl. rheumatoid arthritis, osteoarthritis and acute tissue injury. Dr Hua's research expertise covers the areas of formulation, in vitro studies and preclinical in vivo studies. This expertise provides a solid foundation to formulate and evaluate new drug delivery systems and to apply them to pathological disease states, in order to assess potential clinical applicability and novel mechanistic pathways. Her research provides a platform for the translational development of targeted therapeutics that will ultimately provide a novel therapeutic strategy in clinical disease management.

Teaching Expertise
Dr Hua BPharm (Hons), PhD, MPS is a full time academic at the School of Biomedical Sciences and Pharmacy, Discipline of Pharmacy. She is a registered pharmacist in Australia and has worked a number of years across various facets of pharmacy, including hospital, community and research. Dr Hua is teaching into the areas of Pharmacotherapeutics and Pharmacy Practice in the Bachelor of Pharmacy program at The University of Newcastle. Dr Hua strongly believes in the importance of high quality teaching and positive motivation of pharmacy students and junior pharmacists to sustain the quality use of medicines in the community.

Administrative Expertise
Course coordinator for PHAR2102 - Dermatology and Topical Formulations Course coordinator for PHAR2102 - Cardiovascular and Renal Health Bachelor of Pharmacy - Year 2 Coordinator School Representative on the Faculty of Health Progress and Appeals Committee Pharmacy Advisor on the Institutional Biosafety Committee (IBC)

Keywords

  • Acute and chronic pain
  • Arthritis
  • Inflammation
  • Nano-delivery systems
  • Nanomedicines
  • Opioids
  • Peripheral analgesia
  • Pharmaceutical dosage form design
  • Pharmacotherapeutics
  • Pharmacy Practice
  • Targeted drug delivery

Fields of Research

Code Description Percentage
100709 Nanomedicine 30
110322 Rheumatology and Arthritis 50
111504 Pharmaceutical Sciences 20

Professional Experience

UON Appointment

Title Organisation / Department
Senior Lecturer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Book (1 outputs)

Year Citation Altmetrics Link
2015 Hua SH, Cabot PC, PAIN - Novel Targets and New Technologies, Frontiers in Pharmacology, Switzerland, 95 (2015)

Journal article (19 outputs)

Year Citation Altmetrics Link
2015 Paul J, Hua S, Smith R, 'A Targeted Drug Delivery System for the Uterus', REPRODUCTIVE SCIENCES, 22 57A-57A (2015)
2015 Hua S, Marks E, Schneider JJ, Keely S, 'Advances in oral nano-delivery systems for colon targeted drug delivery in inflammatory bowel disease: Selective targeting to diseased versus healthy tissue.', Nanomedicine, 11 1117-1132 (2015)
DOI 10.1016/j.nano.2015.02.018
Co-authors Jennifer Schneider, Simon Keely
2014 Jobling P, O'Hara K, Hua S, 'Female reproductive tract pain: Targets, challenges, and outcomes', Frontiers in Pharmacology, 5 FEB (2014) [C1]

Pain from the female reproductive tract (FRT) is a significant clinical problem for which there are few effective therapies. The complex neuroanatomy of pelvic organs not only mak... [more]

Pain from the female reproductive tract (FRT) is a significant clinical problem for which there are few effective therapies. The complex neuroanatomy of pelvic organs not only makes diagnosis of pelvic pain disorders difficult but represents a challenge to development of targeted therapies. A number of potential therapeutic targets have been identified on sensory neurons supplying the FRT but our knowledge on the basic neurophysiology of these neurons is limited compared with other viscera. Until this is addressed we can only guess if the new experimental therapies proposed for somatic, gastrointestinal, or bladder pain will translate to the FRT. Once suitable therapeutic targets become clear, the next challenge is drug delivery. The FRT represents a promising system for topical drug delivery that could be tailored to act locally or systemically depending on formulation. Development of these therapies and their delivery systems will need to be done in concert with more robust in vivo and in vitro models of FRT pain. © 2014 Jobling, O'Hara and Hua.

DOI 10.3389/fphar.2014.00017
Citations Scopus - 1Web of Science - 2
Co-authors Phillip Jobling
2014 Hua S, 'Comparison of in vitro dialysis release methods of loperamide-encapsulated liposomal gel for topical drug delivery', International Journal of Nanomedicine, 9 735-744 (2014) [C1]

Background: The purpose of this study was to determine the most appropriate dialysis equilibrium method to assess liposomal gel formulations containing hydrophobic drugs, to give ... [more]

Background: The purpose of this study was to determine the most appropriate dialysis equilibrium method to assess liposomal gel formulations containing hydrophobic drugs, to give the most accurate indication of drug release. Methods: Loperamide hydrochloride-encapsulated liposomes, composed of L-a-phosphatidylcholine and cholesterol (molar ratio of 2:1), were prepared according to the method of dried lipid film hydration. The liposomes were incorporated into a carbopol gel (0.5%, weight/weight). The release of the drug from the nanoparticles was assessed using a number of variations of the dialysis technique, taking into account solubility parameters and formulation. Method 1 (below saturation point) and Method 2 (above saturation point) used a dilution method to evaluate how drug concentration and solubility affects the in vitro drug-release profile of loperamide hydrochloride, while Methods 3 (below saturation point) and 4 (above saturation point) evaluated how drug concentration and the gel base affect the release profile. Results: In Method 1, the liposomes showed a rapid release of just over 60% in the first 3 hours and then a slower, sustained release to just over 70% at 24 hours. Method 2 showed a gradual, sustained release profile with the liposomes with 55% release at 24 hours. In Method 3, the liposomes showed a rapid burst release of 98% at 2 hours. In Method 4, the liposomal gel had a rapid release of 60% within 3 hours and then a more gradual, sustained release with 86% release at 24 hours. The free drug suspension in Methods 2 and 4 showed a limited release across the dialysis membrane, in comparison to Methods 1 and 3, which showed a complete release in a timely manner. Conclusion: This study has demonstrated that the actual method used for equilibrium dialysis plays a significant role in determining the true characteristics of a topical nanoformulation, with Method 3 providing the most accurate indication of the release of a hydrophobic drug from a topical liposomal formulation. © 2014 Hua.

DOI 10.2147/IJN.S55805
Citations Scopus - 3Web of Science - 1
2014 Iwaszkiewicz KS, Hua S, 'Development of an effective topical liposomal formulation for localized analgesia and antiinflammatory actions in the Complete Freund¿s Adjuvant rodent model of acute inflammatory pain', Pain Physician, 17 E719-E735 (2014) [C1]
2014 Jobling P, O'Hara K, Hua S, 'Female reproductive tract pain: targets, challenges, and outcomes.', Front Pharmacol, 5 17 (2014) [C1]
DOI 10.3389/fphar.2014.00017
Citations Scopus - 1Web of Science - 1
Co-authors Phillip Jobling
2014 Hua S, Cabot PJ, 'PAIN - Novel targets and new technologies', Frontiers in Pharmacology, 5 (2014) [C3]
DOI 10.3389/fphar.2014.00211
2014 Hua S, 'Orally administered liposomal formulations for colon targeted drug delivery', Frontiers in Pharmacology, 5 JUN 1-4 (2014) [C2]
DOI 10.3389/fphar.2014.00138
Citations Scopus - 2
2013 Hua S, 'Targeting sites of inflammation: intercellular adhesion molecule-1 as a target for novel inflammatory therapies.', Front Pharmacol, 4 127 (2013) [C1]
DOI 10.3389/fphar.2013.00127
Citations Scopus - 14Web of Science - 13
2013 Iwaszkiewicz KS, Schneider JJ, Hua S, 'Targeting peripheral opioid receptors to promote analgesic and anti-inflammatory actions.', Front Pharmacol, 4 132 (2013) [C1]
DOI 10.3389/fphar.2013.00132
Citations Scopus - 9Web of Science - 8
Co-authors Jennifer Schneider
2013 Hua S, Wu SY, 'The use of lipid-based nanocarriers for targeted pain therapies', Frontiers in Pharmacology, 4 NOV (2013) [C1]
DOI 10.3389/fphar.2013.00143
Citations Scopus - 7Web of Science - 7
2013 Iwaszkiewicz KS, Schneider JJ, Hua S, 'Targeting peripheral opioid receptors to promote analgesic and anti-inflammatory actions', FRONTIERS IN PHARMACOLOGY, 4 (2013) [C1]
DOI 10.3389/fphar.2013.00132
Citations Web of Science - 6
Co-authors Jennifer Schneider
2013 Hua S, Cabot PJ, 'Targeted Nanoparticles that Mimic Immune Cells in Pain Control Inducing Analgesic and Anti-inflammatory Actions: A Potential Novel Treatment of Acute and Chronic Pain Conditions', PAIN PHYSICIAN, 16 E199-E216 (2013) [C1]
Citations Scopus - 12Web of Science - 12
2011 Witting PK, Song C, Hsu K, Hua S, Parry SN, Rye K, et al., 'The acute phase protein serum amyloid A induces endothelial dysfunction that is inhibited by high-density lipoprotein.', Free Radical Biology and Medicine, 51 1390-1398 (2011) [C1]
Citations Scopus - 16Web of Science - 17
2011 Hua S, Chang H-I, Davies N, Cabot PJ, 'Targeting of ICAM-1-directed immunoliposomes specifically to activated endothelial cells with low cellular uptake: use of an optimized procedure for the coupling of low concentrations of antibody to liposomes.', Journal of Liposome Research, 21 95-105 (2011) [C1]
Citations Scopus - 7Web of Science - 6
2010 Hua S, Cabot PJ, 'Mechanisms of peripheral immune-cell-mediated analgesia in inflammation: Clinical and therapeutic implications', Trends in Pharmacological Sciences, 31 427-433 (2010) [C1]
DOI 10.1016/j.tips.2010.05.008
Citations Scopus - 26Web of Science - 24
2009 Rayner BS, Hua S, Sabaretnam T, Witting PK, 'Nitric oxide stimulates myoglobin gene and protein expression in vascular smooth muscle.', Biochemical Journal, 423 169-177 (2009) [C1]
Citations Scopus - 12Web of Science - 11
2009 Hua S, Geczy CL, Freedman SB, Witting PK, 'A role for acute-phase serum amyloid A and high-density lipoprotein in oxidative stress, endothelial dysfunction and atherosclerosis.', Redox Report, 14 187-196 (2009) [C1]
Citations Scopus - 23Web of Science - 20
2006 Hua S, Hermanussen S, Tang L, Monteith GR, Cabot PJ, 'The neural cell adhesion molecule antibody blocks cold water swim stress-induced analgesia and cell adhesion between lymphocytes and cultured dorsal root ganglion neurons', Anesthesia and Analgesia, 103 1558-1564 (2006) [C1]
DOI 10.1213/01.ane.0000243410.61451.c1
Citations Scopus - 19Web of Science - 18
Show 16 more journal articles

Conference (4 outputs)

Year Citation Altmetrics Link
2015 Nguyen TS, Nguyen TLH, Hua S, Li SC, 'Enhancing the role of hospital pharmacists in a developing country - the current scenario in Vietnam', ACCP, Bangkok, Thailand (2015)
2014 Hua S, 'The use of lipid-based nanocarriers for targeting sites of inflammation', 4th Annual Symposium of Drug Delivery Systems, Suzhou, China (2014) [E3]
2014 Hua SH, 'Targeting peripheral opioid receptors to induce analgesic and anti-inflammatory actions', 5th Annual International Congress of Medichem, Suzhou, China (2014) [E3]
2012 Hua S, Cabot PJ, 'Loperamide-formulated immunoliposomes directed towards intercellular adhesion molecule-1 (ICAM-1): A potential tool for specific drug delivery to peripheral inflammatory pain', Abstracts of the 39th Annual Meeting and Exposition of the Controlled Release Society, Quebec, ON (2012) [E3]
Show 1 more conference
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Grants and Funding

Summary

Number of grants 10
Total funding $758,711

Click on a grant title below to expand the full details for that specific grant.


20143 grants / $98,674

JuLI Stage $71,674

Funding body: NHMRC (National Health & Medical Research Council)

Achieving Targeted Delivery of Drugs to Uterine Muscle in Women for the Prevention of Preterm Labour$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Jonathan Paul, Doctor Susan Hua, Professor Roger Smith
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1401504
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

The 4th Annual Symposium of drug Delivery System 2014 (SDDS-2014), Suzhou China, 17 - 20 November 2014$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Susan Hua
Scheme Travel Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400807
Type Of Funding Internal
Category INTE
UON Y

20132 grants / $612,956

Understanding the regulation of hERG potassium channel in the myometrium at the time of labour$577,956

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Roger Smith, Professor Nick Europe-Finner, Doctor Susan Hua
Scheme Project Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1200367
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20122 grants / $21,500

Peripheral immune-derived analgesia: A new target for the treatment of rheumatoid arthritis$20,000

Funding body: Pharmacy Research Trust of NSW

Funding body Pharmacy Research Trust of NSW
Project Team Doctor Susan Hua
Scheme Research Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1101131
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

The 39th Annual Meeting and Exposition of the Controlled Release Society, Quebec City, Canada, 15 - 18 July 2012$1,500

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Susan Hua
Scheme Travel Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200581
Type Of Funding Internal
Category INTE
UON Y

20111 grants / $15,581

Development of novel targeted drug delivery systems specifically to sites of inflammation and its application to peripheral analgesia and inflammation in chronic arthritic pathologies$15,581

Funding body: Rebecca L Cooper Medical Research Foundation Ltd

Funding body Rebecca L Cooper Medical Research Foundation Ltd
Project Team Doctor Susan Hua
Scheme Research Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1000741
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20102 grants / $10,000

Development of Novel Targeted Drug Delivery Systems to Sites of Inflammation$7,395

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Susan Hua
Scheme Early Career Researcher Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G1000970
Type Of Funding Internal
Category INTE
UON Y

Development of Novel Targeted Drug Delivery Systems to Sites of Inflammation$2,605

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Susan Hua
Scheme Early Career Researcher (Equipment) Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G1000683
Type Of Funding Internal
Category INTE
UON Y
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Research Supervision

Current Supervision

Commenced Research Title / Program / Supervisor Type
2014 Improvement of Quality Use of Medicine in Chronic Respiratory Diseases
Pharmacy, Faculty of Health and Medicine
Co-Supervisor
2014 Peripheral Opioid Receptor Targeting for the Relief of Pain, Inflammation and Disease Progression in Rheumatoid Arthritis
Pharmacy, Faculty of Health and Medicine
Principal Supervisor
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Dr Susan Hua

Position

Senior Lecturer
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Pharmacy and Experimental Pharmacology

Contact Details

Email susan.hua@newcastle.edu.au
Phone (02) 49854063
Fax (02) 49217903

Office

Room MS126
Building Medical Science Building
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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