Emeritus Professor Peter Dunkley

Emeritus Professor Peter Dunkley

Emeritus Professor

School of Biomedical Sciences and Pharmacy (Medical Biochemistry)

Career Summary

Biography

Professor Dunkley's research is focused on signal transduction in neuronal and endocrine tissues and especially on protein phosphorylation. Professor Dunkley has published 108 articles in peer reviewed journals and a further 14 refereed reviews and book chapters. His life time citations are 2880, his h-index is 27 and his average number of citations per article is 28. In 2011 the number of citations was over 160. Professor Dunkley was invited by Nature Protocols to write a protocol based on two of his earlier papers which have together been cited 637 times.

Since 2004 he has worked on the activation of tyrosine hydroxylase by protein phosphorylation and his review in J Neurochemistry has been cited 145 times. Professor Dunkley has maintained a strong collaboration and mentoring role with young researchers in Brazil and has published 20 papers with these colleagues. Professor Dunkley has a post-doctoral fellow and two PhD students working with him in 2012. Grants: Professor Dunkley had continuous support from the NHMRC for 31 years until he retired for research in which he was the first named chief investigator. He has also been involved in many other collaborative NHMRC grants as a secondary CI. Professor Dunkley has also had grants from the ARC and many other funding agencies. Recognition: Professor Dunkley has presented his research at 7 overseas conferences over the last 10 years with 5 being invited presentations.

In 2002 Professor Dunkley received the Hunter Medical Research Institute award for research excellence in the form of a $10,000 prize. Professor Dunkley has been the neuroscience representative on the ARC biological sciences panel for 3 years and on an NHMRC RGIC on four occasions, including being the deputy chair of the cellular neuroscience panel in 1999 and deputy chair of the molecular neuroscience panel in 2006. He was on the Medicine and Public Health committee of the ERA in 2010 and the New Zealand PBRF committee in 2012. Professor Dunkley was the President (2002-2003) of the International Society for Neurochemistry (ISN). He still serves as a member of the ISN finance committee. In addition he is a member of the Asian Pacific Society for Neurochemistry (APSN) council. Professor Dunkley was the Foundation Head of The School of Biomedical Sciences at The University of Newcastle (1998-2002) and was the Pro Vice-Chancellor (Health) in 2010-2011. In 2012 he was the Director of the Hunter Medical Research Institute.

Research Expertise

My basic training is that of a protein chemist and I work in the field of cellular and molecular biology. My research focuses on signal transduction mechanisms in neuronal and endocrine tissues and especially on protein phosphorylation. I have focused on a number of key proteins and especially myelin basic protein that is essential for myelin structure, synapsin I that controls neurotransmitter release and tyrosine hydroxylase that is the rate limiting enzyme in catecholamine synthesis. I have investigated these proteins in the context of diseases including Multiple Sclerosis, Parkinsons' disease, depression and anxiety. My focus recently has been on been investigating the phosphorylation of tyrosine hydroxylase at Ser19, Ser31 and Ser40 and tyrosine hydroxylase activity in a number of tissues from the brain and from the adrenal medulla; the tissues have been collected from a range of animal models of stress and from human postmortem Parkinsons' disease patients. I have also had an interest in nutritional biochemistry undertaking occasional studies on the uptake of dissolved nutrients in the Sydney rock oyster; the use of blood glucose monitors in diabetics; the teratogenic and oxidative consequences of ethanol consumption and the effects of vitamin A deficiency on gastrointestinal structure and function.

Teaching Expertise
B Nutrition and Dietetics Professional Skills for Laboratory Scientists-B Biomedical Science Biomedical Sciences Degree and Biomedical Science Hons International Development Programme Visiting Medical Specialist B Medicine

Administrative Expertise
Member of the Griffith and University of Western Sydney Medical School Strategic Advisory Groups Foundation Head, School of Biomedical Sciences Member of the Executive of Faculty of Medicine and Health Sciences Co-ordinator of Space for the Campus University Strategic Planning Task Force elected by Academic Senate Assistant Dean Finance and Personnel/Deputy Director, Medical School University Planning and Resources Committee elected by the University Senate Faculty of Medicine Structure Review Committee Head of Medical Biochemistry (1988-1999).

Qualifications

  • PhD, University of Melbourne
  • Bachelor of Science, University of Melbourne
  • Bachelor of Science (Honours), University of Melbourne

Keywords

  • Biochemistry
  • Catecholamines
  • Depression
  • Medical Biochemistry
  • Neurochemistry
  • Neuroscience
  • Parkinsons' disease
  • Protein chemistry
  • Signal transduction
  • Tyrosine hydroxylase
  • protein phosphorylation

Fields of Research

Code Description Percentage
110199 Medical Biochemistry and Metabolomics not elsewhere classified 10
060199 Biochemistry and Cell Biology not elsewhere classified 40
110999 Neurosciences not elsewhere classified 50

Professional Experience

Academic appointment

Dates Title Organisation / Department
1/01/2007 - 1/12/2007 Invited to Chair Molecular Neuroscience Panel NHMRC (National Health & Medical Research Council)
1/01/2006 - 1/12/2006 Consultant in Restrospective Analysis of Research Grants NHMRC (National Health & Medical Research Council)
1/01/2006 - 1/12/2006 Deputy Chair Molecular Neuroscience Panel NHMRC (National Health & Medical Research Council)
1/01/2005 - 1/07/2005 Consultant in Biomedical Sciences University of Western Sydney
Australia
1/01/2005 - 1/06/2006 Consultant in Biomedical Sciences Griffith University
Australia
1/01/2001 - 1/12/2003 President International Society for Neurochemistry
United Kingdom
1/01/2000 - 1/12/2000 Deputy Chair Neuroscience DP NHMRC (National Health & Medical Research Council)
1/01/1998 - 1/12/2001 Treasurer International Society for Neurochemistry
United Kingdom
1/01/1997 - 1/12/2001 Foundation Head of School of Biomedical Sciences

Biomedical Sciences

University of Newcastle
School of Health
Australia
1/01/1994 - 1/07/2010 Professor of Medical Biochemistry University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/1988 - 1/12/1993 Associate Professor Medical Biochemistry

Medical Biochemistry

University of Newcastle
Faculty of Medicine
Australia
1/01/1982 - 1/12/1987 Senior Lecturer

Medical Biochemistry

University of Newcastle
Faculty of Medicine
Australia
1/02/1978 - 1/12/1981 Foundation Lecturer in Medical Biochemistry University of Newcastle
Faculty of Medicine
Australia
1/09/1976 - 1/02/1978 Research Scientist CSIRO- Plant Biochemistry
Australia
1/01/1975 - 1/09/1976 Exhibition for 1851 Fellow Institute of Psychiatry, London
Biochemistry; Neurochemistry
United Kingdom

Membership

Dates Title Organisation / Department
Member - The American Society for Neurochemistry The American Society for Neurochemistry
United States
Member - International Society for Neurochemistry The International Society for Neurochemistry
Australia
Member - The Australian Society for Biochemistry and Molecular Biology The Australian Society for Biochemistry and Molecular Biology
Australia
1/07/2011 - 1/12/2012 Member New Zealand Performance Based Research Fund
New Zealand
1/01/2010 - 1/12/2010 Member ERA Medicine and Public Health Committee
Australia
1/01/1996 - 31/12/1998 Member - AO Biological Sciences Committee AO Biological Sciences Committee 1996-1998
Australia
1/01/1993 - 31/12/1997 Member - Journal of Neurochemistry Journal of Neurochemistry
Australia
1/01/1992 - 31/12/1995 Member - European Journal of Pharmacology European Journal of Pharmacology
Australia
1/01/1992 - 31/12/1994 Member -NHMRC RGIC Committees NHMRC RGIC Committees
Australia
1/01/1991 - 31/12/1994 Member - Journal of Molecular Neuroscience Journal of Molecular Neuroscience
Australia

Professional appointment

Dates Title Organisation / Department
1/12/2011 - 1/04/2012 Director Hunter Medical Research Institute University of Newcastle
Health
Australia

Teaching appointment

Dates Title Organisation / Department
1/01/1974 - 1/12/1974 Senior Tutor The University of Melbourne
Department of Biochemistry
Australia

Awards

Research Award

Year Award
2002 Award for Research Excellence
HMRI

Invitations

Keynote Speaker

Year Title / Rationale
2011 The Laurie Austin Lecture
Organisation: Australian Neuroscience Society
2008 IBN Lecture
Organisation: Brazil Neuroscience Society

Participant

Year Title / Rationale
2002 Plenary Lecturer
Organisation: Japanese Society for Neurochemistry
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Journal article (143 outputs)

Year Citation Altmetrics Link
2014 Ong LK, Guan L, Damanhuri H, Goodchild AK, Bobrovskaya L, Dickson PW, Dunkley PR, 'Neurobiological consequences of acute footshock stress: effects on tyrosine hydroxylase phosphorylation and activation in the rat brain and adrenal medulla', JOURNAL OF NEUROCHEMISTRY, 128 547-560 (2014) [C1]
DOI 10.1111/jnc.12482
Citations Scopus - 3Web of Science - 2
Co-authors Phil Dickson, Linkooi Ong
2014 Stutz B, Lima da Conceicao FS, Santos LE, Cadilhe DV, Fleming RL, Acquarone M, et al., 'Murine dopaminergic Muller cells restore motor function in a model of Parkinson's disease', JOURNAL OF NEUROCHEMISTRY, 128 829-840 (2014) [C1]
DOI 10.1111/jnc.12475
Citations Scopus - 2Web of Science - 2
Co-authors Phil Dickson
2013 Briggs G, Bulley J, Dunkley PR, Dickson PW, 'Structural Basis for Regulation of Tyrosine Hydroxlyase by the Catecholamines 8-9 (2013) [E3]
DOI 10.1016/B978-0-12-800044-1.00006-4
Co-authors Phil Dickson
2013 Bobrovskaya L, Maniam J, Ong LK, Dunkley PR, Morris MJ, 'Early Life Stress and Post-Weaning High Fat Diet Alter Tyrosine Hydroxylase Regulation and AT1 Receptor Expression in the Adrenal Gland in a Sex Dependent Manner', NEUROCHEMICAL RESEARCH, 38 826-833 (2013) [C1]
DOI 10.1007/s11064-013-0985-4
Citations Scopus - 1Web of Science - 2
Co-authors Linkooi Ong
2013 Sominsky L, Fuller EA, Bondarenko E, Ong LK, Averell L, Nalivaiko E, et al., 'Functional Programming of the Autonomic Nervous System by Early Life Immune Exposure: Implications for Anxiety', PLOS ONE, 8 (2013) [C1]
DOI 10.1371/journal.pone.0057700
Citations Scopus - 10Web of Science - 10
Co-authors Linkooi Ong, Eugene Nalivaiko, Deborah Hodgson, Phil Dickson
2012 Dunkley PR, 'Richard Burnard Rodnight, 1921-2012 [Obituary]', Journal of Neurochemistry, 123 199-201 (2012) [C3]
Citations Scopus - 1Web of Science - 1
2012 Ong LK, Sominsky L, Dickson PW, Hodgson DM, Dunkley PR, 'The sustained phase of Tyrosine hydroxylase activation in vivo', Neurochemical Research, 37 1938-1943 (2012) [C1]
Citations Scopus - 6Web of Science - 5
Co-authors Deborah Hodgson, Phil Dickson, Linkooi Ong
2012 Barreto RDA, Walker FR, Dunkley PR, Day TA, Smith DW, 'Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression?', BMC Neuroscience, 13 1-12 (2012) [C1]
Citations Scopus - 7Web of Science - 9
Co-authors Rohan Walker, Douglas Smith
2012 Dayas CV, Smith DW, Dunkley PR, 'An emerging role for the mammalian Target of Rapamycin (mTOR) in 'pathological' protein translation: Relevance to cocaine addiction', Frontiers in Pharmacology, 3 1-12 (2012) [C1]
Citations Scopus - 9Web of Science - 7
Co-authors Douglas Smith, Christopher Dayas
2012 Damanhuri HA, Burke PGR, Ong LK, Bobrovskaya L, Dickson PW, Dunkley PR, Goodchild AK, 'Tyrosine hydroxylase phosphorylation in catecholaminergic brain regions: A marker of activation following acute hypotension and glucoprivation', Plos One, 7 1-19 (2012) [C1]
Citations Scopus - 10Web of Science - 8
Co-authors Linkooi Ong, Phil Dickson
2011 Ong LK, Guan L, Stutz B, Dickson PW, Dunkley PR, Bobrovskaya L, 'The effects of footshock and immobilization stress on tyrosine hydroxylase phosphorylation in the rat locus coeruleus and adrenal gland', Neuroscience, 192 20-27 (2011) [C1]
DOI 10.1016/j.neuroscience.2011.06.087
Citations Scopus - 7Web of Science - 7
Co-authors Phil Dickson, Linkooi Ong
2011 Ong LK, Bobrovskaya L, Walker FR, Day TA, Dickson PW, Dunkley PR, 'The effect of social defeat on tyrosine hydroxylase phosphorylation in the rat brain and adrenal gland', Neurochemical Research, 36 27-33 (2011) [C1]
DOI 10.1007/s11064-010-0255-7
Citations Scopus - 7Web of Science - 7
Co-authors Linkooi Ong, Phil Dickson, Rohan Walker
2010 Bobrovskaya L, Damanhuri HA, Ong LK, Schneider JJ, Dickson PW, Dunkley PR, Goodchild AK, 'Signal transduction pathways and tyrosine hydroxylase regulation in the adrenal medulla following glucoprivation: An in vivo analysis', Neurochemistry International, 57 162-167 (2010) [C1]
DOI 10.1016/j.neuint.2010.05.009
Citations Scopus - 11Web of Science - 11
Co-authors Jennifer Schneider, Phil Dickson, Linkooi Ong
2010 Double KL, Halliday GM, Dunkley PR, Dickson PW, Gerlach M, Riederer P, 'Pigmentation in the human brain and risk of Parkinson's Disease', Annals of Neurology, 67 553-554 (2010) [C3]
Citations Scopus - 2Web of Science - 1
Co-authors Phil Dickson
2010 Posser T, Dunkley PR, Dickson PW, Franco JL, 'Human neuroblastoma cells transfected with tyrosine hydroxylase gain increased resistance to methylmercury-induced cell death', Toxicology in Vitro, 24 1498-1503 (2010) [C1]
DOI 10.1016/j.tiv.2010.07.015
Citations Scopus - 8Web of Science - 9
Co-authors Phil Dickson
2010 Franco JL, Posser T, Gordon SL, Bobrovskaya L, Schneider JJ, Farina M, et al., 'Expression of tyrosine hydroxylase increases the resistance of human neuroblastoma cells to oxidative insults', Toxicological Sciences, 113 150-157 (2010) [C1]
DOI 10.1093/toxsci/kfp245
Citations Scopus - 10Web of Science - 9
Co-authors Jennifer Schneider, Phil Dickson
2009 Posser T, Franco JL, Bobrovskaya L, Leal RB, Dickson PW, Dunkley PR, 'Manganese induces sustained Ser40 phosphorylation and activation of tyrosine hydroxylase in PC12 cells', Journal of Neurochemistry, 110 848-856 (2009) [C1]
DOI 10.1111/j.1471-4159.2009.06185.x
Citations Scopus - 18Web of Science - 14
Co-authors Phil Dickson
2009 Gordon SL, Bobrovskaya L, Dunkley PR, Dickson PW, 'Differential regulation of human tyrosine hydroxylase isoforms 1 and 2 in situ: Isoform 2 is not phosphorylated at Ser35', Biochimica et Biophysica Acta - Molecular Cell Research, 1793 1860-1867 (2009) [C1]
DOI 10.1016/j.bbamcr.2009.10.001
Citations Scopus - 21Web of Science - 21
Co-authors Phil Dickson
2009 Gordon SL, Webb JK, Shehadeh J, Dunkley PR, Dickson PW, 'The low affinity dopamine binding site on tyrosine hydroxylase: The role of the N-Terminus and in situ regulation of enzyme activity', Neurochemical Research, 34 1830-1837 (2009) [C1]
DOI 10.1007/s11064-009-9989-5
Citations Scopus - 7Web of Science - 6
Co-authors Phil Dickson
2009 Franco JL, Posser T, Dunkley PR, Dickson PW, Mattos JJ, Martins R, et al., 'Methylmercury neurotoxicity is associated with inhibition of the antioxidant enzyme glutathione peroxidase', Free Radical Biology and Medicine, 47 449-457 (2009) [C1]
DOI 10.1016/j.freeradbiomed.2009.05.013
Citations Scopus - 70Web of Science - 66
Co-authors Phil Dickson
2008 Dunkley PR, Jarvie P, Robinson PJ, 'A rapid Percoll gradient procedure for preparation of synaptosomes', Nature Protocols, 3 1718-1728 (2008) [C1]
DOI 10.1038/nprot.2008.171
Citations Scopus - 92Web of Science - 87
2008 Gordon SL, Quinsey NS, Dunkley PR, Dickson PW, 'Tyrosine hydroxylase activity is regulated by two distinct dopamine-binding sites', Journal of Neurochemistry, 106 1614-1623 (2008) [C1]
DOI 10.1111/j.1471-4159.2008.05509.x
Citations Scopus - 19Web of Science - 18
Co-authors Phil Dickson
2007 Bobrovskaya L, Gelain DP, Gilligan C, Dickson PW, Dunkley PR, 'PACAP stimulates the sustained phosphorylation of tyrosine hydroxylase at serine 40', Cellular Signalling, 19 1141-1149 (2007) [C1]
DOI 10.1016/j.cellsig.2006.12.006
Citations Web of Science - 33
Co-authors Conor Gilligan, Phil Dickson
2007 Bobrovskaya L, Gilligan C, Bolster EK, Flaherty JJ, Dickson PW, Dunkley PR, 'Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis', Journal of Neurochemistry, 100 479-489 (2007) [C1]
DOI 10.1111/j.1471-4159.2006.04213.x
Citations Scopus - 49Web of Science - 48
Co-authors Phil Dickson, Conor Gilligan
2007 Gelain DP, Moreira JCF, Bevilaqua LRM, Dickson PW, Dunkley PR, 'Retinol activates tyrosine hydroxylase acutely by increasing the phosphorylation of serine40 and then serine31 in bovine adrenal chromaffin cells', Journal of Neurochemistry, 103 2369-2379 (2007) [C1]
DOI 10.1111/j.1471-4159.2007.04935.x
Citations Scopus - 15Web of Science - 14
Co-authors Phil Dickson
2007 Leal RB, Posser T, Rigon AP, Oliveira CS, Goncalves CA, Gelain DP, Dunkley PR, 'Cadmium stimulates MAPKs and Hsp27 phosphorylation in bovine adrenal chromaffin cells', Toxicology, 234 34-43 (2007) [C1]
DOI 10.1016/j.tox.2007.01.023
Citations Web of Science - 19
2006 Lehmann IT, Bobrovskaya L, Gordon SL, Dunkley PR, Dickson PW, 'Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation', Journal of Biological Chemistry, 281 17644-17651 (2006) [C1]
DOI 10.1074/jbc.M512194200
Citations Scopus - 44Web of Science - 45
Co-authors Phil Dickson
2005 Cechin SR, Dunkley PR, Rodnight RB, 'Signal transduction mechanisms involved in the proliferation of C6 glioma cells induced by lysophosphatidic acid', Neurochemical Research, 30 603-611 (2005) [C1]
DOI 10.1007/s11064-005-2747-4
Citations Scopus - 28Web of Science - 26
2005 Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Characterisation of tryptic peptides of phosphorylated tyrosine hydroxylase by high-pressure liquid chromatography electrospray ionisation mass spectrometry', Journal of Electron Spectroscopy and Related Phenomena, 142 271-276 (2005) [C1]
DOI 10.1016/j.elspec.2004.09.008
Citations Scopus - 2Web of Science - 2
Co-authors Ellak, Phil Dickson
2004 Cordova FM, Rodrigues ALS, Giacomelli MBO, Oliveira CS, Posser T, Dunkley PR, Leal RB, 'Lead stimulates ERK1/2 and p38MAPK phosphorylation in the hippocampus of immature rats', Brain Research, 998 65-72 (2004) [C1]
DOI 10.1016/j.brainres.2003.11.012
Citations Scopus - 53Web of Science - 52
2004 Ma FY, Grattan DR, Bobrovskaya L, Dunkley PR, Bunn SJ, 'Angiotensin II regulates tyrosine hydroxylase activity and mRNA expression in rat mediobasal hypothalamic cultures: the role of specific protein kinases', Journal of Neurochemistry, 90 431-441 (2004) [C1]
DOI 10.1111/j.1471-4159.2004.02492.x
Citations Scopus - 14Web of Science - 15
2004 Dunkley PR, Bobrovskaya L, Graham ME, Von Nagy-Felsobuki EI, Dickson PW, 'Tyrosine hydroxylase phosphorylation: regulation and consequences', Journal of Neurochemistry, 91 1025-1043 (2004) [C1]
DOI 10.1111/j.1471-4159.2004.02797.x
Citations Scopus - 229Web of Science - 229
Co-authors Ellak, Phil Dickson
2004 Roberts-Thomson EL, Herd LM, Saunders H, Dunkley PR, Bunn SJ, 'The tryrosine phosphorylation and cytoskeletal translocation of phospholipase Cy1 in bovine adrenal medullary chromaffin cells', Neurochemical Research, 29 1847-1855 (2004) [C1]
DOI 10.1023/B:NERE.0000042211.76499.c6
Citations Scopus - 1Web of Science - 1
Co-authors Lynn Herd
2004 Frizzo JK, Tramontina F, Bortoli E, Gottfried C, Leal RB, Lengyel I, et al., 'S100B-Mediated Inhibition of the Phosphorylation of GFAP Is Prevented by TRTK-12', Neurochemical Research, 29 735-740 (2004) [C1]
DOI 10.1023/B:NERE.0000018844.51009.40
Citations Scopus - 23
2004 Roberts-Thomson EL, Herd LM, Saunders HI, Dunkley PR, Bunn SJ, 'The tyrosine [correction of tryrosine] phosphorylation and cytoskeletal translocation of phospholipase C gamma 1 in bovine adrenal medullary chromaffin cells.', Neurochemical research, 29 1847-1855 (2004)
DOI 10.1023/b:nere.0000042211.76499.c6
2004 Leal RB, Frizzo JK, Tramontina F, Fieuw-Makaroff S, Bobrovskaya L, Dunkley PR, Goncalves CA, 'S1009B protein stimulates calcineurin activity', NEUROREPORT, 15 317-320 (2004)
DOI 10.1097/01.wnr.0000109328.44017e9
Citations Web of Science - 10
2004 Leal RB, Frizzo JK, Tramontina F, Fieuw-Makaroff S, Bobrovskaya L, Dunkley PR, Goncalves C-A, 'S100B protein stimulates calcineurin activity', NeuroReport, 15 317-320 (2004) [C1]
DOI 10.1097/00001756-200402090-00021
Citations Scopus - 11
2003 Cammarota MP, Bevilaqua L, Rostas JA, Dunkley PR, 'Histamine activates tyrosine hydroxylase in bovine adrenal chromaffin cells through a pathway that involves ERK1/2 but not p38 or JNK', Journal of Neurochemistry, 84 453-458 (2003) [C1]
DOI 10.1046/j.1471-4159.2003.01517.x
Citations Scopus - 25Web of Science - 25
Co-authors John Rostas
2003 Bevilaqua L, Cammarota MP, Dickson PW, Sim AT, Dunkley PR, 'Role of protein phosphatase 2C from bovine adrenal chromaffin cells in the dephosphorylation of phospho-serine 40 tyrosine hydroxylase', Journal of Neurochemistry, 85 1368-1373 (2003) [C1]
DOI 10.1046/j.1471-4159.2003.01792.x
Citations Scopus - 18Web of Science - 18
Co-authors Alistair Sim, Phil Dickson
2003 Powis DA, Zerbes M, Herd LM, Dunkley PR, 'Angiotensin II Causes Calcium Entry into Bovine Adrenal Chromaffin Cells via Pathway(s) Activated by Depletion of Intracellular Calcium Stores', Neurochemical Research, 28 1299-1306 (2003) [C1]
DOI 10.1023/A:1024987128090
Co-authors Lynn Herd
2002 Leal R, Cordova F, Herd LM, Bobrovskaya L, Dunkley PR, 'Lead-Stimulated p38 MARK-Dependent Hsp27 Phosphorylation', Toxicology and Applied Pharmacology, 178 44-51 (2002) [C1]
Citations Scopus - 40Web of Science - 40
Co-authors Lynn Herd
2002 Leal R, Sim AT, Goncalves C, Dunkley PR, 'Tyrosine Hydroxylase Dephosphorylation by Protein Phosphatase 2A in Bovine Adrenal Chromaffin Cells', Neurochemical Research, 27, No 3 207-213 (2002) [C1]
Citations Scopus - 23Web of Science - 24
Co-authors Alistair Sim
2002 Warden RA, Noltorp RA, Bell CJ, O'Loughlin EV, Dunkley PR, Garg ML, 'Vitamin A Deficiency Changes Jejunal Mucosal Fatty Acid Profile in Rats', Journal of Clinical Biochemistry and Nutrition, 31 19-26 (2002) [C1]
Citations Scopus - 1Web of Science - 1
Co-authors Manohar Garg
2002 Graham ME, Bevilaqua LRM, Phillip, Dickson W, Dunkley PR, Von Nagy-Felsobuki EI, 'Kinetic monitoring of protein phosphorylation using quantitative electrospray lonization mass spectrometry', Proceedings 50th ASMS Conference on Mass Spectrometry and Allied Topics, 301-302 (2002)

A kinetic model of protein phosphorylation using quantitative electrospray ionization mass spectrometry (ESI-MS) was discussed. Rate constants were determined in the absence of do... [more]

A kinetic model of protein phosphorylation using quantitative electrospray ionization mass spectrometry (ESI-MS) was discussed. Rate constants were determined in the absence of dopamine only. The analysis showed that the rate of serine 40 phosphorylation was two to three times higher when serine 19 was already phosphorylated. The application of quantitative ESI-MS to enzyme kinetics to provide information on protein structure/function was also demonstrated.

2001 Bevilaqua L, Graham ME, Dunkley PR, Von Nagy-Felsobuki EI, Dickson PW, 'Phosphorylation of Ser19 Alters the Conformation of Tyrosine Hydroxylase to Increase the Rate of Phosphorylation of Ser40*', The Journal of Biological Chemistry, 276 No. 44 40411-40416 (2001) [C1]
Citations Scopus - 62Web of Science - 63
Co-authors Phil Dickson
2001 Leal RB, Cordova FM, Lynn H, Dunkley PR, 'Lead and cadmium stimulate HSP27 phosphorylation in bovine adrenal chromaffin cells', JOURNAL OF NEUROCHEMISTRY, 78 194-194 (2001)
2001 Bobrovskaya L, Odell AF, Leal RB, Dunkley PR, 'Tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells: the role of MAPKs after angiotensin II stimulation', Journal of Neurochemistry, 78 490-498 (2001) [C1]
Citations Web of Science - 29
2001 Cammarota MP, Bevilaqua L, Dunkley PR, Rostas JA, 'Angiotensin II Promotes the Phosphorylation of Cyclic AMP-Responsive Element Binding Protein (CREB) at Ser133 Through an ERK1/2-Dependent Mechanism', Journal of Neurochemistry, 79 1122-1128 (2001) [C1]
Citations Scopus - 32Web of Science - 31
Co-authors John Rostas
2001 Bevilaqua L, Graham ME, Von Nagy-Felsobuki EI, Dunkley PR, Dickson PW, 'Effect of phosphorylation on tyrosine hydroxylase shape', Journal of Neurochemistry, 78 Supt. 1 143 (2001) [C3]
Co-authors Phil Dickson
2001 Cammarota MP, Bevilaqua L, Dunkley PR, Rostas JA, 'Angiotensin II Promotes a Rapid and Reversible Increase in SRC-Tyrosine Kinase Activity in Bovine Adrenal Chromaffin Cells: Effect on MAPK Pathways', Proceedings of the Australian Neuroscience Society, 12 197 (2001) [C3]
Co-authors John Rostas
2001 Bobrovskaya L, Odell AF, Cheah TB, Dunkley PR, 'The Involvement of MAPKs in Angiotensin II-Stimulated Tyrosine Hydroxylase Phosphorylation in Bovine Adrenal Chromaffin Cells', Proceedings of the Australian Neuroscience Society, 12 85 (2001) [C3]
2001 Graham ME, Bevilaqua L, Dunkley PR, Von Nagy-Felsobuki EI, Dickson PW, 'The Kinetics of CAMKII Phosphorylation of Dopamine Bound-Tyrosine Hydroxylase Determined by Electrospray Mass Spectrometry', ComBio 2001, 0 (2001) [C3]
Co-authors Phil Dickson
2001 Cammarota MP, Bevilaqua L, Dunkley PR, Rostas JA, 'Angiotensin II Promotes a Src and ERK 1/2 Dependent Increase in SER133-CREB Phosphorylation', Journal of Neurochemistry, 78 Supl. 1 143 (2001) [C3]
Co-authors John Rostas
2000 Karl J, Gottfried C, Tramontina F, Dunkley PR, Rodnight R, Goncalves CA, 'GFAP phosphorylation studied in digitonin-permeabilized astrocytes: standardization of conditions', Brain Research, 853 32-40 (2000) [C1]
Citations Web of Science - 15
2000 Roberts-Thomson EL, Saunders H, Palmer SM, Powis DA, Dunkley PR, Bunn SJ, 'Ca2+ influx stimulated phospholipase C activity in bovine adrenal chromaffin cells: responses to K+ depolarization and histamine', European Journal of Pharmacology, 398 199-207 (2000) [C1]
Citations Web of Science - 8
2000 Bobrovskaya L, Cheah TB, Dunkley PR, 'Angiotensin II-stimulated tyrosine hydroxylase activity and phosphorylation in bovine adrenal chromaffin cells', JOURNAL OF NEUROCHEMISTRY, 74 S38-S38 (2000)
2000 Lengyel I, Fieuw-Makaroff S, Hall AL, Sim AT, Rostas JA, Dunkley PR, 'Modulation of the Phosphorylation and Activity of Calcium/Calmodulin-Dependent Protein Kinase II by Zinc', Journal of Neurochemistry, 75 No. 2 594-605 (2000) [C1]
Citations Scopus - 54Web of Science - 51
Co-authors John Rostas, Alistair Sim
2000 Goncalves C-A, Gottfried C, Dunkley PR, 'The Use of Permeabilized Cells to Assay Protein Phosphorylatioon and Catecholamine Release', Neurochemical Research, 25 No. 6 885-894 (2000) [C1]
Citations Web of Science - 8
2000 Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Determination of Phosphorylation Levels of Tyrosine Hydroxylase by Electrospray Mass Spectrometry', Analytical Biochemistry, 280 1-7 (2000) [C1]
Citations Web of Science - 8
Co-authors Phil Dickson, Ellak
1999 Bobrovskaya L, Cheah TB, Dunkley PR, 'Phorbol ester-mediated phosphorylation of tyrosine hydroxylase in bovine adrenal chromaffin cells', JOURNAL OF NEUROCHEMISTRY, 72 S25-S25 (1999)
1999 Lengyel I, Hall AL, Fieuw-Makaroff S, Sim ATR, Rostas JAP, Dunkley PR, 'Characterization of the zinc-dependent autophosphorylation sites on calcium/calmodulin-dependent protein kinase II', JOURNAL OF NEUROCHEMISTRY, 73 S33-S33 (1999)
Co-authors John Rostas
1999 Bobrovskaya L, Dickson P, Cheah TB, Dunkley PR, 'The role of mitogen-activated protein kinase in tyrosine hydroxylase phosphorylation.', JOURNAL OF NEUROCHEMISTRY, 73 S34-S34 (1999)
1999 Roberts-Thomson EL, Saunders HI, Dunkley PR, Bunn SJ, 'The effect of insulin on phospholipase C activity in bovine adrenal medullary chromaffin cells.', JOURNAL OF NEUROCHEMISTRY, 73 S50-S50 (1999)
1999 Cheah TB, Bobrovskaya L, Goncalves C-A, Hall RM, Elliot R, Lengyel I, et al., 'Simultaneous measurement of tyrosine hydroxylase activity and phosphorylation in bovine adrenal chomaffin cells', Journal of Neuroscience Methods, 87 167-174 (1999) [C1]
Citations Scopus - 20Web of Science - 20
1998 Bobrovskaya L, Cheah TB, Bunn SJ, Dunkley PR, 'Angiotensin II-mediated phosphorylation of tyrosine hydroxylase in bovine adrenal chromaffin cells', JOURNAL OF NEUROCHEMISTRY, 71 S60-S60 (1998)
1998 Bobrovskaya L, Cheah TB, Bunn SJ, Dunkley PR, 'Tyrosine hydroxylase in bovine adrenal chromaffin cells: Angiotensin II-stimulated activity and phosphorylation of Ser19, Ser31, and Ser40', Journal of Neurochemistry, 70 2565-2573 (1998) [C1]
Citations Scopus - 30Web of Science - 31
1998 Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Characterisation of the phosphorylation of rat tyrosine hydroxylase using electrospray mass spectrometry', Rapid Communications in Mass Spectrometry, 12 746-748 (1998) [C1]
Co-authors Phil Dickson
1998 Graham ME, Dickson P, Dunkley P, Von Nagy-Felsobuki EI, 'Characterization of the Phosphorylation of Rat Tyrosine Hydroxylase using Electrospray Mass Spectrometry', Rapid Communications in Mass Spectrometry, 12 746-748 (1998) [C1]
Citations Web of Science - 6
Co-authors Ellak, Phil Dickson
1997 Brent PJ, Herd L, Saunders H, Sim ATR, Dunkley PR, 'Protein phosphorylation and calcium uptake into rat forebrain synaptosomes: Modulation by the sigma (F) ligand 1,3-ditolylguanidine.', J.Neurochem, 68 2201-2211 (1997) [C1]
1997 Goncalves CA, Hall A, Sim ATR, Bunn SJ, Marley P, Cheah TB, Dunkley PR, 'Tyrosine hydroxylase phosphorylation in digitonin permeabilised bovine adrenal chromaffin cells: The effect of protein kinase and phosphatase inhibitors on Ser-19 and Ser-40 phosphorylation.', J.Neurochem, 69 2387-2396 (1997) [C1]
Citations Scopus - 14Web of Science - 15
1997 Brent PJ, Herd L, Saunders H, Sim ATR, Dunkley PR, 'Protein phosphorylation and calcium uptake into rat forebrain synaptosomes: Modulation by the sigma (sigma) ligand, 1,3-ditolylguanidine', JOURNAL OF NEUROCHEMISTRY, 69 S206-S206 (1997)
1997 Goncalves CA, Hall A, Sim ATR, Bunn SJ, Marley PD, Cheah TB, Dunkley PR, 'Tyrosine hydroxylase phosphorylation in digitonin-permeabilised bovine adrenal chromaffin cells', JOURNAL OF NEUROCHEMISTRY, 69 S207-S207 (1997)
1997 Warden RA, Noltorp RS, Francis JL, Dunkley PR, OLoughlin EV, 'Vitamin A deficiency exacerbates methotrexate-induced jejunal injury in rats', JOURNAL OF NUTRITION, 127 770-776 (1997)
Citations Scopus - 24Web of Science - 24
1997 Bunn SJ, Dunkley PR, 'Histamine-stimulated phospholipase C signalling in the adrenal chromaffin cell: Effects on inositol phospholipid metabolism and tyrosine hydroxylase phosphorylation', CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 24 624-631 (1997)
DOI 10.1111/j.1440-1681.1997.tb02103.x
Citations Scopus - 10Web of Science - 10
1996 Dunkley PR, Cote A, Harrison SM, Herd L, Hall A, Powis DA, 'Tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells - Clonidine stimulates basal but inhibits nicotinic receptor evoked phosphorylation', BIOCHEMICAL PHARMACOLOGY, 51 239-245 (1996)
DOI 10.1016/0006-2952(95)02128-0
Citations Scopus - 12Web of Science - 12
1996 Warden RA, Strazzari MJ, Dunkley PR, OLoughlin EV, 'Vitamin A-deficient rats have only mild changes in jejunal structure and function', JOURNAL OF NUTRITION, 126 1817-1826 (1996)
Citations Scopus - 25Web of Science - 27
1996 Powis DA, OBrien KJ, Harrison SM, Jarvie PE, Dunkley PR, 'Mn2+ can substitute for Ca2+ in causing catecholamine secretion but not for increasing tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells', CELL CALCIUM, 19 419-429 (1996)
DOI 10.1016/S0143-4160(96)90115-3
Citations Web of Science - 14
1996 Powis DA, O'Brien KJ, Harrison SM, Jarvie PE, Dunkley PR, 'Mn2+ can substitute for Ca2+ in causing catecholamine secretion but not for increasing tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells', Cell Calcium, 19 419-429 (1996)

The ability of the divalent cation manganese (Mn2+) to substitute for calcium (Ca2+) both in triggering catecholamine release and in stimulating catecholamine synthesis, as indica... [more]

The ability of the divalent cation manganese (Mn2+) to substitute for calcium (Ca2+) both in triggering catecholamine release and in stimulating catecholamine synthesis, as indicated by an increase in tyrosine hydroxylase (TOH) phosphorylation, has been determined in bovine adrenal medullary chromaffin cells maintained in tissue culture. Mn2+ was found to enter chromaffin cells through pathways activated by nicotinic receptor stimulation and potassium depolarisation, and via the Nai:Cao exchange mechanism in Na+-loaded cells. Like Ca2+, entry of Mn2+ through these pathways triggered immediate catecholamine release and, like Ca2+, maintained quantitatively comparable release at least up to 40 min. Unlike Ca2+, Mn2+ did not stimulate an increase in TOH phosphorylation in intact chromaffin cells, even over a prolonged time course, but Mn2+ did stimulate increased TOH phosphorylation in lysed cell preparations showing that its lack of effect in the intact cells was not due to inhibition of the specific phosphorylation pathway. In lysed cell preparations, Mn2+ stimulated also phosphorylation of a different spectrum of proteins to Ca2+, and of the same proteins to different extents. In particular, P80 (MARCKS protein) was more intensely phosphorylated in the presence of Mn2+ than in the presence of Ca2+. Since TOH phosphorylation always occurs when intracellular Ca2+ is increased, the absence of an increase with Mn2+ indicates that none of its intracellular effects could have occurred as a consequence of Mn2+ mobilisation of intracellular Ca2+. In summary, the data show that Mn2+ is a surrogate for Ca2+ in triggering and maintaining catecholamine release, but does not substitute for Ca2+ in stimulating TOH phosphorylation.

Citations Scopus - 16
1996 Brent PJ, Saunders H, Dunkley PR, 'Intrasynaptosomal free calcium levels in rat forebrain synaptosomes: Modulation by sigma (sigma) receptor ligands', NEUROSCIENCE LETTERS, 211 138-142 (1996)
DOI 10.1016/0304-3940(96)12711-7
Citations Scopus - 12Web of Science - 12
1996 Lengyel I, Nichol KA, Sim ATR, Bennett MR, Dunkley PR, Rostas JAP, 'Characterization of protein kinase and phosphatase systems in chick ciliary ganglion', NEUROSCIENCE, 70 577-588 (1996)
DOI 10.1016/0306-4522(95)00356-8
Citations Scopus - 8Web of Science - 9
Co-authors John Rostas
1996 Amini SA, Dunkley PR, Murdoch RN, 'Teratogenic effects of ethanol in the Quackenbush Special mouse', DRUG AND ALCOHOL DEPENDENCE, 41 61-69 (1996)
DOI 10.1016/0376-8716(96)01231-8
Citations Scopus - 5Web of Science - 5
1996 Amini SA, Dunstan RH, Dunkley PR, Murdoch RN, 'Oxidative stress and the fetotoxicity of alcohol consumption during pregnancy', FREE RADICAL BIOLOGY AND MEDICINE, 21 357-365 (1996)
DOI 10.1016/0891-5849(96)00027-5
Citations Scopus - 28Web of Science - 23
Co-authors Hugh Dunstan
1995 BRENT PJ, HAYNES H, JARVIE PE, MUDGE L, SIM ATR, DUNKLEY PR, 'PHOSPHORYLATION OF SYNAPSIN I AND DYNAMIN IN RAT FOREBRAIN SYNAPTOSOMES - MODULATION BY SIGMA (SIGMA) LIGANDS', NEUROSCIENCE LETTERS, 191 71-74 (1995)
DOI 10.1016/0304-3940(95)11562-1
Citations Scopus - 8Web of Science - 6
1995 SITGES M, DUNKLEY PR, CHIN LM, 'A ROLE FOR CALCIUM/CALMODULIN KINASE(S) IN THE REGULATION OF GABA EXOCYTOSIS', NEUROCHEMICAL RESEARCH, 20 245-252 (1995)
DOI 10.1007/BF00969539
Citations Scopus - 14Web of Science - 10
1995 Jarvie PE, Dunkley PR, 'Characterization of calcium/calmodulin-stimulated protein kinase II.', Methods in molecular biology (Clifton, N.J.), 41 239-259 (1995)
Citations Scopus - 15
1995 Amini SA, Walsh K, Dunstan R, Dunkley PR, Murdoch RN, 'Maternal hepatic, endometrial, and embryonic levels of Zn, Mg, Cu, and Fe following alcohol consumption during pregnancy in QS mice', RESEARCH COMMUNICATIONS IN ALCOHOL AND SUBSTANCES OF ABUSE, 16 207-219 (1995)
Citations Scopus - 1Web of Science - 1
1995 WARDEN R, FRANCIS L, DUNKLEY P, OLOUGHLIN E, 'VITAMIN-A-DEFICIENCY POTENTIATES METHOTREXATE (MTX) ENTEROPATHY IN RATS', GASTROENTEROLOGY, 108 A762-A762 (1995)
1995 BUNN SJ, SIM ATR, HERD LM, AUSTIN LM, DUNKLEY PR, 'TYROSINE-HYDROXYLASE PHOSPHORYLATION IN BOVINE ADRENAL CHROMAFFIN CELLS - THE ROLE OF INTRACELLULAR CA2+ IN THE HISTAMINE H-1 RECEPTOR-STIMULATED PHOSPHORYLATION OF SER(8), SER(19), SER(31), AND SER(40)', JOURNAL OF NEUROCHEMISTRY, 64 1370-1378 (1995)
Citations Scopus - 34Web of Science - 36
1995 DUNKLEY PR, BUNN SJ, SIM ATR, AUSTIN L, HERD L, HALL A, BUCKENHAM AJ, 'INTRACELLULAR CALCIUM-DEPENDENT PHOSPHORYLATION OF TYROSINE-HYDROXYLASE IN BOVINE ADRENAL CHROMAFFIN CELLS', JOURNAL OF NEUROCHEMISTRY, 65 S5-S5 (1995)
1995 BRENT PJ, MUDGE L, DUNKLEY PR, 'MODULATION OF PROTEIN-PHOSPHORYLATION BY THE SELECTIVE SIGMA-LIGAND DTG IN RAT CORTICAL SYNAPTOSOMES IS CALCIUM-DEPENDENT AND INHIBITED BY THE SIGMA-ANTAGONIST RIMCAZOLE', JOURNAL OF NEUROCHEMISTRY, 65 S14-S14 (1995)
Citations Web of Science - 1
1995 BUCKENHAM AJ, GONCALVES CA, HALL A, DUNKLEY PR, 'CALCIUM/CALMODULIN-DEPENDENT PROTEIN-KINASE-II IN INTACT BOVINE ADRENAL CHROMAFFIN CELLS', JOURNAL OF NEUROCHEMISTRY, 65 S16-S16 (1995)
1995 SITGES M, DUNKLEY PR, CHIU LM, 'A ROLE FOR CALCIUM-CALMODULIN KINASE(S) IN THE REGULATION OF GABA EXOCYTOSIS', JOURNAL OF NEUROCHEMISTRY, 65 S19-S19 (1995)
1995 BUNN SJ, SAUNDERS HI, DUNKLEY PR, 'HISTAMINE-STIMULATED INOSITOL PHOSPHOLIPID-METABOLISM IN BOVINE ADRENAL-MEDULLARY CELLS - A KINETIC-ANALYSIS', JOURNAL OF NEUROCHEMISTRY, 65 626-635 (1995)
Citations Scopus - 14Web of Science - 11
1994 WARDEN RA, STRAZZARI MJ, DUNKLEY PR, OLOUGHLIN EV, 'THE EFFECT OF VITAMIN-A-DEFICIENCY ON INTESTINAL STRUCTURE AND FUNCTION', GASTROENTEROLOGY, 106 A639-A639 (1994)
1993 BUNN SJ, BOYD TE, DUNKLEY PR, 'KINETIC-ANALYSIS OF HISTAMINE-STIMULATED INOSITOL PHOSPHOLIPID-METABOLISM IN BOVINE ADRENAL CHROMAFFIN CELLS', JOURNAL OF NEUROCHEMISTRY, 61 S104-S104 (1993)
1993 SIM ATR, RATCLIFFE E, DUNKLEY PR, ROSTAS JAP, 'MEMBRANE-BOUND FORMS OF PROTEIN PHOSPHATASE TYPE-1 AND TYPE-2A HAVE LOWER ACTIVITY THAN CYTOSOLIC FORMS IN BRAIN', JOURNAL OF NEUROCHEMISTRY, 61 S136-S136 (1993)
Co-authors John Rostas
1993 BUNN SJ, AUSTIN LM, HERD LM, DUNKLEY PR, 'HISTAMINERGIC PHOSPHORYLATION OF TYROSINE-HYDROXYLASE IN BOVINE ADRENAL CHROMAFFIN CELLS', JOURNAL OF NEUROCHEMISTRY, 61 S153-S153 (1993)
1993 LENGYEL I, NICHOL KA, BENNETT MR, ROSTAS JAP, DUNKLEY PR, 'PROTEIN-PHOSPHORYLATION IN CHICK CILIARY GANGLION', JOURNAL OF NEUROCHEMISTRY, 61 S221-S221 (1993)
Co-authors John Rostas
1993 SIM ATR, LLOYD HGE, JARVIE PE, MORRISON M, ROSTAS JAP, DUNKLEY PR, 'SYNAPTOSOMAL AMINO-ACID RELEASE - EFFECT OF INHIBITING PROTEIN PHOSPHATASES WITH OKADAIC ACID', NEUROSCIENCE LETTERS, 160 181-184 (1993)
DOI 10.1016/0304-3940(93)90408-D
Citations Scopus - 17Web of Science - 19
Co-authors John Rostas
1992 KIDD GJ, HEATH JW, TRAPP BD, DUNKLEY PR, 'MYELIN SHEATH SURVIVAL AFTER GUANETHIDINE-INDUCED AXONAL DEGENERATION', JOURNAL OF CELL BIOLOGY, 116 395-403 (1992)
DOI 10.1083/jcb.116.2.395
Citations Scopus - 2Web of Science - 5
1992 BUNN SJ, HARRISON SM, DUNKLEY PR, 'PROTEIN-PHOSPHORYLATION IN BOVINE ADRENAL-MEDULLARY CHROMAFFIN CELLS - HISTAMINE-STIMULATED PHOSPHORYLATION OF TYROSINE-HYDROXYLASE', JOURNAL OF NEUROCHEMISTRY, 59 164-174 (1992)
DOI 10.1111/j.1471-4159.1992.tb08887.x
Citations Scopus - 17Web of Science - 18
1992 ROSTAS JAP, DUNKLEY PR, 'MULTIPLE FORMS AND DISTRIBUTION OF CALCIUM/CALMODULIN-STIMULATED PROTEIN KINASE-II IN BRAIN', JOURNAL OF NEUROCHEMISTRY, 59 1191-1202 (1992)
DOI 10.1111/j.1471-4159.1992.tb08428.x
Citations Scopus - 40Web of Science - 49
Co-authors John Rostas
1992 PRESEK P, JESSEN S, DREYER F, JARVIE PE, FINDIK D, DUNKLEY PR, 'TETANUS TOXIN INHIBITS DEPOLARIZATION-STIMULATED PROTEIN-PHOSPHORYLATION IN RAT CORTICAL SYNAPTOSOMES - EFFECT ON SYNAPSIN-I PHOSPHORYLATION AND TRANSLOCATION', JOURNAL OF NEUROCHEMISTRY, 59 1336-1343 (1992)
DOI 10.1111/j.1471-4159.1992.tb08445.x
Citations Scopus - 21Web of Science - 20
1992 CAMPBELL EM, REDMAN S, DUNKLEY PR, MOFFITT PS, 'THE USE OF PORTABLE BLOOD-GLUCOSE MONITORS BY TRAINED LAY OPERATORS', MEDICAL JOURNAL OF AUSTRALIA, 157 446-448 (1992)
Citations Scopus - 3Web of Science - 3
1991 BUNN SJ, DUNKLEY PR, 'OPIOID INHIBITION OF NICOTINE-INDUCED CA-45(2+)-UPTAKE INTO CULTURED BOVINE ADRENAL-MEDULLARY CELLS', BIOCHEMICAL PHARMACOLOGY, 41 715-722 (1991)
DOI 10.1016/0006-2952(91)90071-C
Citations Scopus - 12Web of Science - 15
1991 Thorne B, Wonnacott S, Dunkley PR, 'Isolation of hippocampal synaptosomes on percoll gradients: Cholinergic markers and ligand binding sites', Journal of Neurochemistry, 56 479-484 (1991)

The S1 Percoll procedure, devised empirically for cortical tissue, provides highly purified, functionally viable synaptosomes on a four-step Percoll gradient. Here, for the first ... [more]

The S1 Percoll procedure, devised empirically for cortical tissue, provides highly purified, functionally viable synaptosomes on a four-step Percoll gradient. Here, for the first time, the procedure has been applied to rat hippocampus, and the gradient fractions have been analysed with respect to cholinergic markers and the synaptosomal index, lactate dehydrogenase. The presynaptic cholinergic markers choline acetyltransferase and [3H]choline uptake were most enriched in fraction 4. In contrast, acetylcholinesterase activity was broadly distributed across the gradient, consistent with the separation of synaptic plasma membranes (in fractions 1 and 2) from synaptosomes (in fractions 3 and 4). This is supported by the recovery of muscarinic binding sites labelled with [3H]quinuclidinylbenzilate in fractions 1 and 2. (-)-[3H]-Nicotine binding sites, however, were most enriched in fraction 4, consistent with their predominantly presynaptic localisation in the CNS. These results demonstrate the applicability of the S1 Percoll method to discrete brain regions for the recovery of homogeneous and viable synaptosome fractions. The separation of presynaptic terminals from postsynaptic membranes is a further advantage of this technique.

Citations Scopus - 18
1991 KIDD GJ, HEATH JW, TRAPP BD, LITTLE GJ, DUNKLEY PR, 'MYELIN SHEATH MAINTENANCE IN THE ABSENCE OF AXONS', ANNALS OF THE NEW YORK ACADEMY OF SCIENCES, 633 549-549 (1991)
1991 SIM ATR, DUNKLEY PR, JARVIE PE, ROSTAS JAP, 'MODULATION OF SYNAPTOSOMAL PROTEIN-PHOSPHORYLATION DEPHOSPHORYLATION BY CALCIUM IS ANTAGONIZED BY INHIBITION OF PROTEIN PHOSPHATASES WITH OKADAIC ACID', NEUROSCIENCE LETTERS, 126 203-206 (1991)
DOI 10.1016/0304-3940(91)90554-7
Citations Scopus - 23Web of Science - 29
Co-authors John Rostas
1991 HEATH JW, KIDD GJ, TRAPP BD, DUNKLEY PR, 'MYELIN MAINTENANCE BY SCHWANN-CELLS IN THE ABSENCE OF AXONS', NEUROSCIENCE LETTERS, 128 277-280 (1991)
DOI 10.1016/0304-3940(91)90279-3
Citations Scopus - 2Web of Science - 6
1991 JEITNER TM, JARVIE PE, COSTA M, ROSTAS JAP, DUNKLEY PR, 'PROTEIN-PHOSPHORYLATION IN GUINEA-PIG MYENTERIC GANGLIA AND BRAIN - PRESENCE OF CALMODULIN KINASE-II, PROTEIN-KINASE-C AND CYCLIC-AMP KINASE AND CHARACTERIZATION OF MAJOR PHOSPHOPROTEINS', NEUROSCIENCE, 40 555-569 (1991)
DOI 10.1016/0306-4522(91)90141-A
Citations Scopus - 9Web of Science - 14
Co-authors John Rostas
1991 DUNKLEY PR, 'AUTOPHOSPHORYLATION OF NEURONAL CALCIUM CALMODULIN-STIMULATED PROTEIN KINASE-II', MOLECULAR NEUROBIOLOGY, 5 179-202 (1991)
DOI 10.1007/BF02935545
Citations Scopus - 17Web of Science - 11
1991 DUNKLEY PR, COTE A, HARRISON SM, 'AUTOPHOSPHORYLATION OF CALMODULIN-STIMULATED PROTEIN KINASE-II IN INTACT SYNAPTOSOMES', JOURNAL OF MOLECULAR NEUROSCIENCE, 2 193-201 (1991)
Citations Scopus - 4Web of Science - 6
1989 O'Dea K, Dunkley P, MacMahon B, Seal J, Birkbeck J, Court J, et al., 'Methods and models for introducing nutrition into the medical curriculum', Medical Journal of Australia, 151 (1989)
1989 ROSTAS JAP, BRENT VA, SECCOMBE M, WEINBERGER RP, DUNKLEY PR, 'PURIFICATION AND CHARACTERIZATION OF CALMODULIN-STIMULATED PROTEIN KINASE-II FROM 2-DAY AND ADULT CHICKEN FOREBRAIN', JOURNAL OF MOLECULAR NEUROSCIENCE, 1 93-104 (1989)
DOI 10.1007/BF02918895
Citations Scopus - 8Web of Science - 10
Co-authors John Rostas
1989 Rostas JAP, Brent VA, Seccombe M, Weinberger RP, Dunkley PR, 'Purification and characterization of calmodulin-stimulated protein kinase II from two-day and adult chicken forebrain', Journal of Molecular Neuroscience, 1 93-104 (1989)

Soluble calmodulin-stimulated protein kinase II has been purified from 2-day and adult chicken forebrain At both ages the holoenzyme eluted from a Superose-6B column with an appar... [more]

Soluble calmodulin-stimulated protein kinase II has been purified from 2-day and adult chicken forebrain At both ages the holoenzyme eluted from a Superose-6B column with an apparent molecular weight of approximately 700,000 daltons and contained three subunits. The subunits were found to be the counterparts of the alpha, beta, and betá subunits of the enzyme purified from adult rat brain in that they had one-dimensional phosphopeptide maps that were indistinguishable from those of the corresponding subunit in the rat enzyme and they migrated in SDS-polyacrylamide gels with the same apparent molecular weights. However, the doublet formed by the beta subunit was much more clearly resolved in the chicken enzyme and the betá subunit, which was much more abundant in the adult chicken than in the adult rat, was also found to be a doublet. The ratio of the concentrations of the alpha and beta subunits changed during development. By autoradiography following autophosphorylation, the alpha:beta ratios of the 2-day and adult enzymes were 0.89±0.07 and 1.92±0.26, reapectively; by silver staining the alpha:beta ratios were 0.95±0.11 and 1.85±0.17, respectively. The concentration of the betá subunit was equal to that of the beta subunit at both ages. Autophosphorylation produced a decrease in the electrophoretic mobility of the alpha and beta subunits in SDS-polyacrylamide gels and a marked decrease in the calcium dependence of the substrate phosphorylation activity of the enzyme at both ages. The purified enzyme from chicken brain appeared to be more stable under standard in vitro assay conditions than the rat enzyme, and this was particularly so for the enzyme from 2-day forebrain. © 1989 Humana Press Inc.

DOI 10.1007/BF02918895
Co-authors John Rostas
1988 DUNKLEY PR, HEATH JW, HARRISON SM, JARVIE PE, GLENFIELD PJ, ROSTAS JAP, 'A RAPID PERCOLL GRADIENT PROCEDURE FOR ISOLATION OF SYNAPTOSOMES DIRECTLY FROM AN S-1 FRACTION - HOMOGENEITY AND MORPHOLOGY OF SUBCELLULAR-FRACTIONS', BRAIN RESEARCH, 441 59-71 (1988)
DOI 10.1016/0006-8993(88)91383-2
Citations Scopus - 279Web of Science - 316
Co-authors John Rostas
1988 HARRISON SM, JARVIE PE, DUNKLEY PR, 'A RAPID PERCOLL GRADIENT PROCEDURE FOR ISOLATION OF SYNAPTOSOMES DIRECTLY FROM AN S-1 FRACTION - VIABILITY OF SUBCELLULAR-FRACTIONS', BRAIN RESEARCH, 441 72-80 (1988)
DOI 10.1016/0006-8993(88)91384-4
Citations Scopus - 29Web of Science - 38
1988 DUNKLEY PR, JARVIE PE, ROSTAS JAP, 'DISTRIBUTION OF CALMODULIN-STIMULATED AND CYCLIC AMP-STIMULATED PROTEIN-KINASES IN SYNAPTOSOMES', JOURNAL OF NEUROCHEMISTRY, 51 57-68 (1988)
DOI 10.1111/j.1471-4159.1988.tb04835.x
Citations Scopus - 9Web of Science - 20
Co-authors John Rostas
1988 THORNE B, IRONS J, LUNT GG, WONNACOTT S, DUNKLEY PR, 'COMPARISON OF METHODS FOR RAPID ISOLATION OF SYNAPTOSOMES FROM BRAIN-REGIONS, FOR UPTAKE AND RELEASE STUDIES', BIOCHEMICAL SOCIETY TRANSACTIONS, 16 309-310 (1988)
Citations Web of Science - 8
1987 ROBINSON PJ, DUNKLEY PR, 'ALTERED PROTEIN-PHOSPHORYLATION IN INTACT RAT CORTICAL SYNAPTOSOMES AFTER INVIVO ADMINISTRATION OF FLUPHENAZINE', BIOCHEMICAL PHARMACOLOGY, 36 2203-2208 (1987)
DOI 10.1016/0006-2952(87)90151-1
Citations Scopus - 3Web of Science - 2
1987 ROBINSON PJ, HAUPTSCHEIN R, LOVENBERG W, DUNKLEY PR, 'DEPHOSPHORYLATION OF SYNAPTOSOMAL PROTEINS P96 AND P139 IS REGULATED BY BOTH DEPOLARIZATION AND CALCIUM, BUT NOT BY A RISE IN CYTOSOLIC CALCIUM ALONE', JOURNAL OF NEUROCHEMISTRY, 48 187-195 (1987)
DOI 10.1111/j.1471-4159.1987.tb13146.x
Citations Web of Science - 46
1987 Rostas JAP, Brent V, Dunkley PR, 'The effect of calmodulin and autophosphorylation on the activity of calmodulin-stimulated protein kinase II', Neuroscience Research Communications, 1 3-8 (1987)
Citations Scopus - 5
Co-authors John Rostas
1986 DUNKLEY PR, JARVIE PE, HEATH JW, KIDD GJ, ROSTAS JAP, 'A RAPID METHOD FOR ISOLATION OF SYNAPTOSOMES ON PERCOLL GRADIENTS', BRAIN RESEARCH, 372 115-129 (1986)
DOI 10.1016/0006-8993(86)91464-2
Citations Scopus - 280Web of Science - 366
Co-authors John Rostas
1986 KIDD GJ, HEATH JW, DUNKLEY PR, 'SELECTIVE DEGENERATION OF MYELINATED SYMPATHETIC-NERVES FOLLOWING TREATMENT WITH GUANETHIDINE', JOURNAL OF ANATOMY, 149 250-250 (1986)
1986 DUNKLEY PR, BAKER CM, ROBINSON PJ, 'DEPOLARIZATION-DEPENDENT PROTEIN-PHOSPHORYLATION IN RAT CORTICAL SYNAPTOSOMES - CHARACTERIZATION OF ACTIVE PROTEIN-KINASES BY PHOSPHOPEPTIDE ANALYSIS OF SUBSTRATES', JOURNAL OF NEUROCHEMISTRY, 46 1692-1703 (1986)
Citations Scopus - 33Web of Science - 60
1986 DUNKLEY PR, ROBINSON PJ, 'DEPOLARIZATION-DEPENDENT PROTEIN-PHOSPHORYLATION IN SYNAPTOSOMES - MECHANISMS AND SIGNIFICANCE', PROGRESS IN BRAIN RESEARCH, 69 273-293 (1986)
DOI 10.1016/S0079-6123(08)61065-1
Citations Scopus - 31Web of Science - 60
1986 ROSTAS JAP, WEINBERGER RP, DUNKLEY PR, 'MULTIPLE POOLS AND MULTIPLE FORMS OF CALMODULIN-STIMULATED PROTEIN-KINASE DURING DEVELOPMENT - RELATIONSHIP TO POSTSYNAPTIC DENSITIES', PROGRESS IN BRAIN RESEARCH, 69 355-371 (1986)
DOI 10.1016/S0079-6123(08)61070-5
Citations Scopus - 15Web of Science - 26
Co-authors John Rostas
1986 KIDD GJ, HEATH JW, DUNKLEY PR, 'DEGENERATION OF MYELINATED SYMPATHETIC-NERVE FIBERS FOLLOWING TREATMENT WITH GUANETHIDINE', JOURNAL OF NEUROCYTOLOGY, 15 561-572 (1986)
DOI 10.1007/BF01611857
Citations Scopus - 8Web of Science - 13
1986 ROSTAS JAP, BRENT VA, HEATH JW, NEAME RLB, POWIS DA, WEINBERGER RP, DUNKLEY PR, 'THE SUBCELLULAR-DISTRIBUTION OF A MEMBRANE-BOUND CALMODULIN-STIMULATED PROTEIN-KINASE', NEUROCHEMICAL RESEARCH, 11 253-268 (1986)
DOI 10.1007/BF00967973
Citations Scopus - 14Web of Science - 23
Co-authors John Rostas
1985 ROBINSON PJ, DUNKLEY PR, 'DEPOLARIZATION-DEPENDENT PROTEIN-PHOSPHORYLATION AND DEPHOSPHORYLATION IN RAT CORTICAL SYNAPTOSOMES IS MODULATED BY CALCIUM', JOURNAL OF NEUROCHEMISTRY, 44 338-348 (1985)
DOI 10.1111/j.1471-4159.1985.tb05422.x
Citations Scopus - 41Web of Science - 65
1984 ROBINSON PJ, JARVIE PE, DUNKLEY PR, 'DEPOLARIZATION-DEPENDENT PROTEIN-PHOSPHORYLATION IN RAT CORTICAL SYNAPTOSOMES IS INHIBITED BY FLUPHENAZINE AT A STEP AFTER CALCIUM ENTRY', JOURNAL OF NEUROCHEMISTRY, 43 659-667 (1984)
DOI 10.1111/j.1471-4159.1984.tb12785.x
Citations Scopus - 13Web of Science - 21
1984 NELL JA, DUNKLEY PR, 'EFFECTS OF TEMPERATURE, NUTRITIONAL FACTORS AND SALINITY ON THE UPTAKE OF L-METHIONINE BY THE SYDNEY ROCK OYSTER SACCOSTREA-COMMERCIALIS', MARINE BIOLOGY, 80 335-339 (1984)
DOI 10.1007/BF00392829
Citations Scopus - 8Web of Science - 11
1984 ROBINSON PJ, DUNKLEY PR, 'IS THERE A ROLE FOR CALCIUM-STIMULATED PROTEIN-PHOSPHORYLATION IN NEUROTRANSMITTER RELEASE', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 16 S40-S40 (1984)
1984 WEINBERGER RP, DUNKLEY PR, ROSTAS JAP, 'DEVELOPMENTAL ACCUMULATION OF A CALMODULIN STIMULATED PROTEIN-KINASE IN SYNAPTIC-MEMBRANES', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 16 87-87 (1984)
Citations Web of Science - 1
Co-authors John Rostas
1983 ROBINSON PJ, DUNKLEY PR, 'DEPOLARIZATION-DEPENDENT PROTEIN-PHOSPHORYLATION IN RAT CORTICAL SYNAPTOSOMES - FACTORS DETERMINING THE MAGNITUDE OF THE RESPONSE', JOURNAL OF NEUROCHEMISTRY, 41 909-918 (1983)
DOI 10.1111/j.1471-4159.1983.tb09034.x
Citations Scopus - 49Web of Science - 84
1983 NELL JA, SKEEL ME, DUNKLEY P, 'UPTAKE OF SOME DISSOLVED ORGANIC NUTRIENTS BY THE SYDNEY ROCK OYSTER SACCOSTREA-COMMERCIALIS', MARINE BIOLOGY, 74 313-318 (1983)
DOI 10.1007/BF00403457
Citations Scopus - 8Web of Science - 8
1983 ROBINSON PJ, DUNKLEY PR, 'DEPOLARIZATION-DEPENDENT PROTEIN-PHOSPHORYLATION IN RAT CORTICAL SYNAPTOSOMES - THE EFFECTS OF CALCIUM, STRONTIUM AND BARIUM', NEUROSCIENCE LETTERS, 43 85-90 (1983)
DOI 10.1016/0304-3940(83)90133-7
Citations Scopus - 21Web of Science - 32
1983 ROSTAS JAP, BRENT VA, DUNKLEY PR, 'THE MAJOR CALMODULIN-STIMULATED PHOSPHOPROTEIN OF SYNAPTIC JUNCTIONS AND THE MAJOR POST-SYNAPTIC DENSITY PROTEIN ARE DISTINCT', NEUROSCIENCE LETTERS, 43 161-165 (1983)
DOI 10.1016/0304-3940(83)90181-7
Citations Scopus - 8Web of Science - 18
Co-authors John Rostas
1983 DUNKLEY PR, ROBINSON PJ, 'THE INVITRO PHOSPHORYLATION OF ACTIN FROM RAT CEREBRAL-CORTEX', NEUROCHEMICAL RESEARCH, 8 865-871 (1983)
DOI 10.1007/BF00964547
Citations Scopus - 5Web of Science - 13
1981 DUNKLEY PR, ROBINSON PJ, 'CALCIUM-STIMULATED PROTEIN-KINASES FROM RAT CEREBRAL-CORTEX ARE INACTIVATED BY PRE-INCUBATION', BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 102 1196-1202 (1981)
DOI 10.1016/S0006-291X(81)80138-6
Citations Scopus - 13Web of Science - 25
1981 DUNKLEY PR, ROBINSON PJ, 'PREINCUBATION OF SUB-CELLULAR FRACTIONS FROM RAT CEREBRAL-CORTEX INACTIVATES PROTEIN-PHOSPHORYLATION', BIOCHEMICAL JOURNAL, 199 269-272 (1981)
Citations Web of Science - 13
1980 DUNKLEY PR, 'IS PROTEIN-PHOSPHORYLATION INVOLVED IN NEUROTRANSMISSION IN THE CENTRAL NERVOUS-SYSTEM', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 13 Q5-Q5 (1980)
1980 DUNKLEY PR, 'PHOSPHORYLATION OF SYNAPTOSOMAL PROTEINS INVITRO - THE EFFECT OF HYPOTONIC LYSIS AND TRITON X-100', PROCEEDINGS OF THE AUSTRALIAN BIOCHEMICAL SOCIETY, 13 118-118 (1980)
Show 140 more journal articles

Conference (45 outputs)

Year Citation Altmetrics Link
2014 Ong LK, Briggs GD, Dunkley PR, Dickson PW, 'The role of inflammation and dopamine synthesis in Parkinson's disease', JOURNAL OF NEUROCHEMISTRY, Kaohsiung, TAIWAN (2014) [E3]
Co-authors Phil Dickson, Linkooi Ong
2013 Guan L, Werno M, Gordon SL, Dunkley P, Dickson PW, 'The effect of tyrosine hydroxylase on alpha-synuclein aggregation', JOURNAL OF NEUROCHEMISTRY, Cancun, MEXICO (2013) [E3]
Co-authors Phil Dickson
2013 Dickson P, Shehadeh J, Double K, Bobrovskaya L, Reyes S, Dunkley P, Halliday G, 'Analysis of Tyrosine Hydroxylase Isoforms and Phosphorylation in Parkinson's Disease' (2013) [E3]
DOI 10.1016/B978-0-12-800044-1.00011-8
2012 Sominsky Bar L, Fuller AE, Bondarenko E, Ong LK, Clark VR, Bobrovskaya L, et al., 'Neonatal programming of the autonomic nervous system by immunological challenge: Implications for anxiety', Abstracts of the 21st Annual Meeting of the International Behavioral Neuroscience Society, Kona, Hawaii (2012) [E3]
Co-authors Linkooi Ong, Deborah Hodgson, Eugene Nalivaiko
2012 Guan L, Werno M, Gordon SL, Dunkley PR, Dickson PW, 'Effect of tyrosine hydroxylase on alphasynuclein aggregation', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authors Phil Dickson
2012 James MH, Charnley JL, Levi EM, Dunkley PR, Smith DW, Dickson PW, Dayas CV, 'A role for the mTOR pathway in the development of addiction', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]
Co-authors Christopher Dayas, Phil Dickson, Douglas Smith
2012 Ong LK, Guan L, Bobrovskaya L, Dickson PW, Dunkley PR, 'Neurobiological consequences of acute footshock stress', Journal of Neurochemistry, Kobe, Japan (2012) [E3]
Co-authors Linkooi Ong, Phil Dickson
2012 Sominsky Bar L, Fuller EA, Bondarenko E, Ong LK, Clark VR, Bobrovskaya L, et al., 'Neonatal immune challenge induces anxiety in adulthood and is associated with functional alterations to the autonomic nervous system', Brain, Behavior, and Immunity, San Diego, CA (2012) [E3]
Co-authors Deborah Hodgson, Linkooi Ong, Eugene Nalivaiko
2011 Barreto RDA, Walker FR, Dunkley PR, Day TA, Smith DW, 'Alteration of neurotrophic factor pathway gene expression in the rat infralimbic medial prefrontal cortex by subchronic restraint stress is reversed by fluoxetine', Posters. Australian Neuroscience Society 31st Annual Meeting, Auckland, New Zealand (2011) [E3]
Co-authors Douglas Smith, Rohan Walker
2011 Damanhuri H, Bobrovskaya L, Dunkley P, Goodchild A, 'Effect of barodenervation on tyrosine hydroxylase phosphorylation in rat brain following hypotension', FASEB JOURNAL, Washington, DC (2011) [E3]
2010 Damanhuri H, Bobrovskaya L, Dunkley PR, Goodchild AK, 'Effect of glucoprivation and hypotension on tyrosine hydroxylase phosphorylation in different catecholmine cell groups in the rat brainstem', Journal of Neurochemistry, Phuket, Thailand (2010) [E3]
2010 Ong LK, Guan L, Stutz B, Dickson PW, Dunkley PR, Bobrovskaya L, 'Tyrosine hydroxylase phosphorylation in response to footshock and restraint stress', Journal of Neurochemistry, Phuket, Thailand (2010) [E3]
DOI 10.1093/jac/dkq221
Citations Scopus - 1
Co-authors Phil Dickson, Linkooi Ong
2009 Bobrovskaya L, Damanhuri H, Ong LK, Dickson PW, Dunkley PR, Goodchild AK, 'The effect of glucoprivation on tyrosine hydroxylase phosphorylation in adrenals of Sprague-Dawley rats', Autonomic Neuroscience: Basic and Clinical, Sydney, NSW (2009) [E3]
DOI 10.1016/j.autneu.2009.05.191
Co-authors Linkooi Ong, Phil Dickson
2009 Damanhuri H, Ong LK, Bobrovskaya L, Dunkley PR, Goodchild AK, 'Activation of tyrosine hydroxylase in the A8, A9 and A10 cell groups following hypotension and glucoprivation in Sprague Dawley rat', Autonomic Neuroscience: Basic and Clinical, Sydney, NSW (2009) [E3]
DOI 10.1016/j.autneu.2009.05.228
Co-authors Linkooi Ong
2009 Ong LK, Maniam J, Dunkley PR, Bobrovskaya L, Morris MJ, 'The effect of voluntary exercise and high fat diet on tyrosine hydroxylase phosphorylation in male Sprague-Dawley rats exposed to early life stress', Autonomic Neuroscience: Basic and Clinical, Sydney, NSW (2009) [E3]
DOI 10.1016/j.autneu.2009.05.192
Co-authors Linkooi Ong
2009 Bobrovskaya L, Ong LK, Walker RA, Day TA, Dickson PW, Dunkley PR, 'The effect of social stress on tyrosine hydroxylase phosphorylation', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authors Linkooi Ong, Phil Dickson
2009 Gordon SL, Dunkley PR, Dickson PW, 'The low affinity dopamine binding site regulates tyrosine hydroxylase activity in situ: Implications for the regulation of cytosolic catecholamine levels', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authors Phil Dickson
2009 Briggs GD, Gordon SL, Dunkley PR, Dickson PW, 'Localisation of the low affinity catecholamine binding site in tyrosine hydroxylase', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
Co-authors Phil Dickson
2009 Gordon SL, Bobrovskaya L, Dunkley PR, Dickson PW, 'Differential regulation of the two major isoforms of human tyrosine hydroxylase in situ', Journal of Neurochemistry, Busan, Korea (2009) [E3]
DOI 10.1111/j.1471-4159.2009.06242.x
Co-authors Phil Dickson
2009 Ong LK, Bobrovskaya L, Walker FR, Day TA, Dickson PW, Dunkley PR, 'The effect of social conflict on tyrosine hydroxylase phosphorylation in catecholamine-producing cells from sprague-dawley rats', Journal of Neurochemistry, Busan, Korea (2009) [E3]
DOI 10.1111/j.1471-4159.2009.06242.x
Co-authors Linkooi Ong, Rohan Walker, Phil Dickson
2009 Dickson PW, Shehadeh J, Double KL, Bobrovskaya L, Reyes S, Dunkley PR, Halliday GM, 'Distribution of tyrosine hydroxylase isoforms in the human brain', Journal of Neurochemistry, Busan, Korea (2009) [E3]
DOI 10.1111/j.1471-4159.2009.06239.x
Co-authors Phil Dickson
2009 Shehadeh J, Double K, Murphy K, Bobrovskaya L, Reyes S, Dunkley PR, et al., 'Differential distribution of tyrosine hydroxylase isoforms in the human brain', Parkinsonism & Related Disorders, Miami Beach, FL (2009) [E3]
Co-authors Phil Dickson
2008 Gelain DP, Mareira JC, Bevilaqua LRM, Dickson PW, Dunkley PR, 'Retinol stimulates tyrosine hydroxylase activity by increasing ser40 phosphorylation in bovine adrenal chromaffin cells', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authors Phil Dickson
2008 Lonergan T, Bobrovskaya L, Dunkley PR, Dickson PW, Pilowsky PM, Goodchild A, 'Intracellular signaling pathways in catecholaminergic cells activitated by glucoprivation', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authors Phil Dickson
2008 Posser T, Franco JL, Bobrovskaya L, Leal RB, Dickson PW, Dunkley PR, 'Sustained tyrosine hydroxylase phosphorylation in pc12 cells exposed to manganese', Proceedings of the Australian Neuroscience Society, Hobart, TAS (2008) [E3]
Co-authors Phil Dickson
2008 Gelain DP, Moreira JC, Bevilaqua LRM, Dickson PW, Dunkley PR, 'Retinol stimulates tyrosine hydroxylase activity by increasing ser40 and then ser 31 phosphorylation in bovine adrenal chromaffin cells', Journal of Neurochemistry, Shanghai, China (2008) [E3]
Co-authors Phil Dickson
2007 Bobrovskaya L, Gelain D, Gilligan C, Flaherty J, Bolster EK, Dickson PW, Dunkley PR, 'Nicotine and Pacap stimulate the sustained phosphorylation of tyrosine hydroxylase at serine 40 (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
Co-authors Conor Gilligan, Phil Dickson
2007 Gordon SL, Quinsey NS, Dunkley PR, Dickson PW, 'Tyrosine hydroxylase activity is regulated by two distinct dopamine binding sites (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program, Melbourne (2007) [E3]
Co-authors Phil Dickson
2007 Gelain DP, Moreira JC, Bevilaqua LR, Dickson PW, Dunkley PR, 'Retinol stimulates tyrosine hydroxylase activity by increasing Ser40 phosphorylation in bovine adrenal chromaffin cells', JOURNAL OF NEUROCHEMISTRY, Cancun, MEXICO (2007)
Co-authors Phil Dickson
2006 Dunkley PR, 'Sustained phosphorylation of tyrosine hydroxylase at serine 40: a novel mechanism for maintenance of catecholamine synthesis', Journal of Neurochemistry, Singapore (2006) [E3]
2006 Dunkley PR, Bobrovskaya L, Gilligan C, Bolster EK, Flaherty J, Dickson PW, 'Sustained phosphorylation of tyrosine hydroxylase at serine 40 is inhibited by the antidepressant imipramine', Proceedings of the Australian Neuroscience Society, Sydney, NSW (2006) [E3]
Co-authors Phil Dickson, Conor Gilligan
2006 Lehmann IT, Bobrovskaya L, Dunkley PR, Dickson PW, 'Differential regulation of the human tyrosine hydroxylase isoforms via hierarchical phosphorylation', Proceedings of the Australian Neuroscience Society, Sydney (2006) [E3]
Co-authors Phil Dickson
2005 Dunkley PR, Bobrovskaya L, Gilligan C, Soster E, Dickson PW, 'Sustained phosphorylation of tyrosine hydroxylase at Ser40', JOURNAL OF NEUROCHEMISTRY, Innsbruck, AUSTRIA (2005) [E1]
Co-authors Phil Dickson, Conor Gilligan
2005 Lehmann IT, Bobrovskaya L, Dunkley PR, Dickson PW, 'Phosphorylation of Ser31 increases the activation of tyrosine hydroxylase via hierarchical phosphorylation', JOURNAL OF NEUROCHEMISTRY, Innsbruck, AUSTRIA (2005) [E1]
Co-authors Phil Dickson
2004 Bobrovskaya L, Dunkley PR, Dickson PW, 'Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells', Journal of Neurochemistry, England (2004) [E1]
DOI 10.1111/j.1471-4159.2004.02550.x
Citations Scopus - 40Web of Science - 42
Co-authors Phil Dickson
2004 Bobrovskaya L, Bolster EK, Dickson PW, Dunkley PR, 'Angiotensin II-Stimulated phosphorylation of tyrosine hydroxylase in bovine adrenal chromaffin cells: The role of PKC isozymes', Proceedings of the Australian Neuroscience Society, Melbourne, Australia (2004) [E3]
Co-authors Phil Dickson
2004 Cechin SR, Jacques-Silva MC, Dunkley PR, Rodnight RB, 'Involvement of RhoA pathway and the Na+/H+ exchanger in the LPA-induced proliferation of the C6 glioma cells', Journal of Neurochemistry, Hong Kong (2004) [E3]
2004 Dunkley PR, Bobrovskaya L, Dickson PW, Rose J, Lehmann IT, 'Hierarchical phosphorylation of tyrosine hydroxylase in bovine adrenal chromaffin cells', Journal of Neurochemistry, Hong Kong (2004) [E3]
Co-authors Phil Dickson
2003 Bobrovskaya L, Dickson PW, Dunkley PR, 'Hierarchical Phosphorylation of SER19 and SER40 on Tyrosine Hydroxylase in Bovine Adrenal Chromaffin Cells', Proccedings of the Australian Neuroscience Society, Adelaide, Australia (2003) [E3]
Co-authors Phil Dickson
2003 Bobrovskaya L, Dunkley PR, Dickson PW, 'Phosphorylation of Ser19 increases both Ser40 phosphorylation and enzyme activity of tyrosine hydroxylase in intact cells', JOURNAL OF NEUROCHEMISTRY, WANCHAI, PEOPLES R CHINA (2003) [E1]
Co-authors Phil Dickson
2001 Graham ME, Dickson PW, Dunkley PR, Von Nagy-Felsobuki EI, 'Quantification of phosphorylation levels of tyrosine hydroxylase utilkizing protein cleavage and electrospray mass spectrometry', Advances in Mass Spectrometry, Barcelona, Spain (2001) [E3]
Co-authors Ellak, Phil Dickson
2001 Bobrovskaya L, Odell A, Dunkley PR, 'Tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells: the involvement of MAPKs after angiotensin II stimulation', JOURNAL OF NEUROCHEMISTRY (2001) [E3]
Citations Scopus - 30
1996 Warden RA, Noltorp RS, Bell CJ, Dunkley PR, OLoughlin EV, 'Intestinal permeability in vitamin A deficient rats', PROCEEDINGS OF THE NUTRITION SOCIETY OF AUSTRALIA, VOL 20, SYDNEY, AUSTRALIA (1996)
1996 Warden RA, Noltorp R, Francis L, Dunkley PR, OLoughlin EV, 'Vitamin A deficiency potentiates methotrexate-induced enteropathy', EUROPEAN JOURNAL OF CLINICAL NUTRITION, MIJDRECHT, NETHERLANDS (1996)
Citations Scopus - 1
1994 WARDEN RA, STRAZZARI MJ, DUNKLEY PR, OLOUGHLIN EV, 'Vitamin A deficiency and gastrointestinal structure and function', PROCEEDINGS OF THE NUTRITION SOCIETY OF AUSTRALIA, VOL 18, NEWCASTLE, AUSTRALIA (1994)
Show 42 more conferences
Edit

Grants and Funding

Summary

Number of grants 73
Total funding $8,408,345

Click on a grant title below to expand the full details for that specific grant.


20141 grants / $245,679

Role of infection in the development of Parkinson's Disease $245,679

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1301295
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20121 grants / $354,601

Human tyrosine hydroxylase isoforms and susceptibility of dopaminergic neurons to degeneration in Parkinson's disease$354,601

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Associate Professor Kay Double
Scheme Project Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100113
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20111 grants / $25,000

Brain Mechanisms Conferring Psychostimulant Addiction$25,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Chris Dayas, Emeritus Professor Peter Dunkley, Doctor Doug Smith
Scheme Near Miss Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1001052
Type Of Funding Internal
Category INTE
UON Y

20101 grants / $24,686

The central neural pathway that controls the release of catecholaines from the adrenal medulla: It is impaired in hypertension?$24,686

Funding body: Hunter Children`s Research Foundation

Funding body Hunter Children`s Research Foundation
Project Team Doctor Larisa Bobrovskaya, Associate Professor Ann Goodchild, Emeritus Professor Peter Dunkley
Scheme Research Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0900143
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20092 grants / $545,000

20083 grants / $559,204

Dopamine mechanisms conferring resilience to depression: A new antidepressant target$538,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Trevor Day, Emeritus Professor Peter Dunkley, Professor David Pow, Doctor Doug Smith
Scheme Project Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0187604
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Neurobiology of sustained phosphorylation$18,800

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Larisa Bobrovskaya, Emeritus Professor Peter Dunkley
Scheme Pilot Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0189081
Type Of Funding Internal
Category INTE
UON Y

Asian Pacific Society for Neurochemistry Biennial Meeting, Hope Island, Shanghai, China, 23/6/2008 - 26/6/2008$1,904

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley
Scheme Travel Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188912
Type Of Funding Internal
Category INTE
UON Y

20074 grants / $771,575

Heat Shock Proteins in Myometrium$437,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Roger Smith, Emeritus Professor Peter Dunkley, Professor Alistair Sim, Conjoint Associate Professor Andrew Bisits
Scheme Project Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0186406
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Differential regulation of human tyrosine hydroxylase isoforms and the development of Parkinson's disease$312,750

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Associate Professor Kay Double
Scheme Project Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0186394
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Vulnerability to depression: the role of dopamine pathways$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Trevor Day, Emeritus Professor Peter Dunkley, Doctor Doug Smith, Professor David Pow
Scheme Near Miss Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187196
Type Of Funding Internal
Category INTE
UON Y

7th International Brain Research Organisation World Congress of Neuroscience, Melbourne, 12/7/2007 - 17/7/2007$1,075

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley
Scheme Travel Grant
Role Lead
Funding Start 2007
Funding Finish 2007
GNo G0187748
Type Of Funding Internal
Category INTE
UON Y

20066 grants / $2,007,868

Advanced technology for transcriptomics, genomics and gene mapping$850,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Rodney Scott, Professor Ian Dawes, Professor Ronald Trent, Professor Nicholas Hunt, Emeritus Professor Peter Bergquist, Professor Mark Baker, Emeritus Professor Peter Dunkley, Dr Ruby Lin, Conjoint Professor Peter Gibson, Professor Alistair Sim
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0185547
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

PRC - Priority Research Centre for Brain & Mental Health Research (CBMHR)$524,282

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Chris Levi, Professor Amanda Baker, Professor Mike Calford, Professor Trevor Day, Emeritus Professor Peter Dunkley, Professor Michael Hazelton, Professor Andrew Heathcote, Professor Brian Kelly, Conjoint Professor Vaughan Carr, Emeritus Professor Patricia Michie, Professor David Pow, Emeritus Professor John Rostas, Professor Ulli Schall, Professor Alistair Sim, Professor Mike Startup
Scheme Priority Research Centre
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186947
Type Of Funding Internal
Category INTE
UON Y

Differential regulation of human tyrosine hydroxyase isoforms and susceptibility of dopaminergic neurons to degeneration$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Associate Professor Kay Double
Scheme Near Miss Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0186079
Type Of Funding Internal
Category INTE
UON Y

Asian Pacific Society for Neurochemistry (APSN), 2-5 July 2006$1,448

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley
Scheme Travel Grant
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0186518
Type Of Funding Internal
Category INTE
UON Y

BioRad Mini-PROTEAN3 Electrophoresis system$995

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Emeritus Professor Leonie Ashman, Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Professor Judith Scott, Professor Alistair Sim, Doctor Nikki Verrills
Scheme Equipment Grant
Role Investigator
Funding Start 2006
Funding Finish 2006
GNo G0187280
Type Of Funding Not Known
Category UNKN
UON Y

20054 grants / $576,189

A novel mechanism for the maintenance of catecholamine synthesis$351,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
Scheme Project Grant
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0184211
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Control of Dopamine synthesis and Parkinsons' disease$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
Scheme Project Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0185977
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Regulation of Human Tyrosine Hydroxylase Isoforms by Hierarchical Phosphorylation$8,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
Scheme Project Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0184779
Type Of Funding Internal
Category INTE
UON Y

20041 grants / $187,341

Biacore3000-Expansion of Proteomics Facility$187,341

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Alistair Sim, Laureate Professor John Aitken, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Emeritus Professor Leonie Ashman, Professor Roger Smith, Professor Gordon Burns, Professor Adam McCluskey, Associate Professor Paul Tooney, Dr Fraser Ross, Conjoint Professor Ray Rose
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0183030
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

20034 grants / $170,000

Hierarchical Phosphorylation of Tyrosine Hydroxylase is Dependent on the Activation Sequence of Signaling Pathways.$135,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
Scheme Discovery Projects
Role Investigator
Funding Start 2003
Funding Finish 2003
GNo G0182096
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Molecular Mechanisms of Lead-Induced Neurotoxicity$15,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley, Dr Perry Hartfield
Scheme Project Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0182478
Type Of Funding Internal
Category INTE
UON Y

Signal transduction in clutured astrocytes in relation to morphology and intracellular hydrogen ion concentration (pHi)$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Richard Rodnight, Emeritus Professor Peter Dunkley
Scheme Project Grant
Role Investigator
Funding Start 2003
Funding Finish 2003
GNo G0182429
Type Of Funding Internal
Category INTE
UON Y

Sparke Helmore Prime Television Corporate Triathlon Award for Research Excellence$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Emeritus Professor Peter Dunkley
Scheme Research Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0182732
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

20024 grants / $777,647

Proteomic and Genomic Analysis Facility.$473,332

Funding body: Wellcome Trust

Funding body Wellcome Trust
Project Team Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Professor Rodney Scott, Emeritus Professor Leonie Ashman
Scheme Major Equipment Award
Role Investigator
Funding Start 2002
Funding Finish 2002
GNo G0181527
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Control of catecholamine synthesis and secretion by angiotensin II$270,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
Scheme Project Grant
Role Lead
Funding Start 2002
Funding Finish 2002
GNo G0180883
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Peltier Thermal Cycler and associated equipment essential for establishing cDNA Retroviral Libraries$21,315

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Leonie Ashman, Dr Petranel Ferrao, Professor Gordon Burns, Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Professor Dirk Van Helden, Dr Perry Hartfield
Scheme Equipment Grant
Role Investigator
Funding Start 2002
Funding Finish 2002
GNo G0181919
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Heat Shock Protein Function in Nerve Cell Death$13,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Dr Perry Hartfield, Emeritus Professor Peter Dunkley
Scheme Project Grant
Role Investigator
Funding Start 2002
Funding Finish 2002
GNo G0181348
Type Of Funding Internal
Category INTE
UON Y

20014 grants / $62,540

The Effect of Lead on Cells$26,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Emeritus Professor Peter Dunkley, Dr Perry Hartfield
Scheme NIB Hunter Golf Professionals Charity Golf Day
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0180752
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Control of Catecholamine Synthesis by Tyrosine Hydroxylase.$13,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Emeritus Professor Ellak Von Nagy-Felsobuki, Professor Alistair Sim
Scheme Project Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0180125
Type Of Funding Internal
Category INTE
UON Y

Thermocycler with 96 well sample block for PCR reactions. Class II Biological Safety Cabinet. Liquid Nitrogen storage Dewar & Transport Dewar$11,770

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Peter Dunkley, Professor Alistair Sim, Professor Dirk Van Helden, Professor Robert Callister
Scheme Equipment Grant
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0181178
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Thermocycler with 96 well sample block for PCR reactions. Class II Biological Safety Cabinet. Liquid Nitrogen storage Dewar & Transport Dewar$11,770

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley, Professor Alistair Sim, Professor Dirk Van Helden, Professor Robert Callister
Scheme University/NHMRC Equipment Grant Funds
Role Lead
Funding Start 2001
Funding Finish 2001
GNo G0181179
Type Of Funding Internal
Category INTE
UON Y

20004 grants / $64,000

Neurolucida Imaging System.$24,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Loris Chahl, Associate Professor Paul Tooney, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas
Scheme Equipment Grant
Role Investigator
Funding Start 2000
Funding Finish 2000
GNo G0179167
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Control of Catecholamine Synthesis by Tyrosine Hydroxylase.$14,500

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson, Emeritus Professor Ellak Von Nagy-Felsobuki
Scheme Small Grant
Role Lead
Funding Start 2000
Funding Finish 2000
GNo G0178980
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Regulating the Regulator: Using Immunochemical Tools to Reveal How CaMPK-II is Controlled by Phosporylation In Vivo.$13,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Dr Martin Cammarota, Dr Sabine Fieuw-Makaroff
Scheme Project Grant
Role Investigator
Funding Start 2000
Funding Finish 2000
GNo G0178869
Type Of Funding Internal
Category INTE
UON Y

Mechanisms of ATP-stimulated phosphorylation and activation of tyrosine hydroxylase.$12,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Dr Tat Cheah, Emeritus Professor Peter Dunkley, Conjoint Professor David Powis
Scheme Project Grant
Role Investigator
Funding Start 2000
Funding Finish 2000
GNo G0178904
Type Of Funding Internal
Category INTE
UON Y

19994 grants / $241,816

Mechanisms of angiotensin-stimulated phosphorylation & activation of tyrosine hydroxylase$203,316

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Peter Dunkley, Conjoint Professor David Powis, Dr Tat Cheah
Scheme Project Grant
Role Lead
Funding Start 1999
Funding Finish 1999
GNo G0178348
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

FPLC Protein Purification System$16,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alistair Sim, Emeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Associate Professor Phillip Dickson
Scheme Equipment Grant
Role Investigator
Funding Start 1999
Funding Finish 1999
GNo G0180790
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Determination of the Phosphorylation States of Tyrosine Hyroxylase in Bovine Adrenal Chromaffin Cells by Electrospray Mass Spectrometry.$13,500

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Emeritus Professor Ellak Von Nagy-Felsobuki, Emeritus Professor Peter Dunkley
Scheme Small Grant
Role Investigator
Funding Start 1999
Funding Finish 1999
GNo G0178016
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Development of a cellular model to study regulation of neurotransmitter synthesis$9,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Phillip Dickson, Emeritus Professor Peter Dunkley
Scheme Project Grant
Role Investigator
Funding Start 1999
Funding Finish 1999
GNo G0178050
Type Of Funding Internal
Category INTE
UON Y

19983 grants / $66,000

Molecular Dynamics Storm 860 Tri-mode Analysis System$35,000

Funding body: Ramaciotti Foundations

Funding body Ramaciotti Foundations
Project Team Professor Alistair Sim, Emeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Dr Stephen Bunn, Dr Tat Cheah, Conjoint Professor Kenneth Beagley, Conjoint Professor Ray Rose, Professor Judith Scott, Doctor Cheng Chan, Professor Roger Smith
Scheme Research Grant
Role Investigator
Funding Start 1998
Funding Finish 1998
GNo G0177453
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Identification of protein phosphatases acting on Tyrosine Hydroxylase in bovine adrenal chromaffin cells.$19,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley, Professor Alistair Sim, Dr Tat Cheah
Scheme Project Grant
Role Lead
Funding Start 1998
Funding Finish 1998
GNo G0177219
Type Of Funding Internal
Category INTE
UON Y

Determination of the Phoshorylation States of Tyrosine Hydroxylase in Bovine Adrenal Chromaffin Cells by Electrospray Mass Spectrometry$12,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Emeritus Professor Ellak Von Nagy-Felsobuki, Emeritus Professor Peter Dunkley
Scheme Small Grant
Role Investigator
Funding Start 1998
Funding Finish 1998
GNo G0177304
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

19976 grants / $557,193

Newcastle Protein - A Protein Sequencing and Analysis Unit of the Newcastle Biomolecular Research Facility.$200,000

Funding body: Department of Education, Training & Youth Affairs

Funding body Department of Education, Training & Youth Affairs
Project Team Emeritus Professor Peter Dunkley
Scheme Research Infrastructure Equipment & Facilities (RIEF)
Role Lead
Funding Start 1997
Funding Finish 1997
GNo G0176524
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Role of Protein Phosphorylation in the Control of Glutamate Release from Nerve Terminals.$178,409

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Peter Dunkley, Dr B Walmsley, Professor Alistair Sim, Dr Stephen Bunn
Scheme Project Grant
Role Lead
Funding Start 1997
Funding Finish 1997
GNo G0176252
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Exocytosis and the Calcium Regulation of Phospholipase C Isozymes$143,284

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Peter Dunkley, Dr Stephen Bunn
Scheme Project Grant
Role Lead
Funding Start 1997
Funding Finish 1997
GNo G0176253
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Modulation of Neurotransmitted Release by Carboxyl-methylation and tyrosine Phosphorylation of Protein Phosphatase type 2A.$18,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Alistair Sim, Doctor Paul Brent, Emeritus Professor Peter Dunkley
Scheme Small Grant
Role Investigator
Funding Start 1997
Funding Finish 1997
GNo G0176731
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Biomedical applications using an electrospray mass spectrometer$15,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Emeritus Professor Ellak Von Nagy-Felsobuki, Emeritus Professor Peter Dunkley
Scheme Small Grant
Role Investigator
Funding Start 1997
Funding Finish 1997
GNo G0176739
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

International society for Neurochemistry, Boston, USA, 20-25 July 1997$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley
Scheme Travel Grant
Role Lead
Funding Start 1997
Funding Finish 1997
GNo G0179452
Type Of Funding Internal
Category INTE
UON Y

19963 grants / $66,000

Microscope and infra-red camera$42,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Dr Pankaj Sah, Dr B Walmsley, Emeritus Professor Peter Dunkley, Professor Dirk Van Helden
Scheme Equipment Grant
Role Investigator
Funding Start 1996
Funding Finish 1996
GNo G0175473
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Establishment of techniques for preparing genetically engineered molecules to study the regulation of neuronal and cellular function$12,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Professor Robert Callister
Scheme Project Grant
Role Investigator
Funding Start 1996
Funding Finish 1996
GNo G0175744
Type Of Funding Internal
Category INTE
UON Y

Effects of angiotensin II on tyrosine hydroxylase activity and phosphorylation in bovine adrenal chromaffin cells.$12,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley, Dr Tat Cheah, Dr Stephen Bunn
Scheme Project Grant
Role Lead
Funding Start 1996
Funding Finish 1996
GNo G0175838
Type Of Funding Internal
Category INTE
UON Y

19956 grants / $401,743

The mechanism and significance of tyrosine hydroxylase phosphorylation.$166,805

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Peter Dunkley, Dr Stephen Bunn, Dr Tat Cheah
Scheme Project Grant
Role Lead
Funding Start 1995
Funding Finish 1995
GNo G0174549
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Regulation of signal transduction pathways by sigma ligands: mechanisms and significance.$144,626

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Paul Brent, Emeritus Professor Peter Dunkley
Scheme Project Grant
Role Investigator
Funding Start 1995
Funding Finish 1995
GNo G0174539
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Neuroscience Group$59,000

Funding body: Department of Education, Training & Youth Affairs

Funding body Department of Education, Training & Youth Affairs
Project Team Emeritus Professor Peter Dunkley
Scheme Research Infrastructure Block Grant (RIBG)
Role Lead
Funding Start 1995
Funding Finish 1995
GNo G0175584
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

95APP. High resolution purification of intra-cellular signalling proteins from brain by FPLC.$20,000

Funding body: Ramaciotti Foundations

Funding body Ramaciotti Foundations
Project Team Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas
Scheme Research Grant
Role Investigator
Funding Start 1995
Funding Finish 1995
GNo G0174696
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Establishment of new model systems and techniques for studying neurotransmision$9,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Dr B Walmsley
Scheme Project Grant
Role Lead
Funding Start 1995
Funding Finish 1995
GNo G0174902
Type Of Funding Internal
Category INTE
UON Y

15th Biennial Mtg of Intern. Society for Neurochemistry, Japan, 2-7 July$2,312

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley
Scheme Travel Grant
Role Lead
Funding Start 1995
Funding Finish 1995
GNo G0176857
Type Of Funding Internal
Category INTE
UON Y

19945 grants / $58,000

Mechanism of Nitric Oxide Modulation of Secretion in Autonomic Ganglia$22,500

Funding body: National Heart Foundation of Australia

Funding body National Heart Foundation of Australia
Project Team Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas
Scheme Grant-In-Aid
Role Lead
Funding Start 1994
Funding Finish 1994
GNo G0175235
Type Of Funding Aust Competitive - Non Commonwealth
Category 1NS
UON Y

Establishment of new model systems and techniques for studying neurotransmission$13,500

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Emeritus Professor John Rostas, Emeritus Professor Peter Dunkley, Dr B Walmsley
Scheme Small Grant
Role Investigator
Funding Start 1994
Funding Finish 1994
GNo G0174822
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

94 APP The effect of Vitamin A deficiency on intestinal structure, function and mucosal repair$11,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Ms Rosemary Warden, Ted O'Loughlin, Emeritus Professor Peter Dunkley
Scheme Project Grant
Role Investigator
Funding Start 1994
Funding Finish 1994
GNo G0174784
Type Of Funding Internal
Category INTE
UON Y

The control of tyrosine hydroxylase activity by protein phosphorylation.$6,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley, Dr Stephen Bunn, Professor Alistair Sim
Scheme Project Grant
Role Lead
Funding Start 1994
Funding Finish 1994
GNo G0174737
Type Of Funding Internal
Category INTE
UON Y

Do sigma binding site ligands modulate neurotransmission by molecular mechanisms involving protein phosphorylation in neuronal tissue$5,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Paul Brent, Emeritus Professor Peter Dunkley, Professor Alistair Sim
Scheme Project Grant
Role Investigator
Funding Start 1994
Funding Finish 1994
GNo G0174732
Type Of Funding Internal
Category INTE
UON Y

19932 grants / $245,861

Autophosphorylation of Calcium/Calmodulin-stimulated Protein Kinase II.$243,361

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Peter Dunkley
Scheme Project Grant
Role Lead
Funding Start 1993
Funding Finish 1993
GNo G0173162
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

'Intern. Society for Neurochemistry', Montpellier, France, 22 - 27 August 1993$2,500

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Emeritus Professor Peter Dunkley
Scheme Travel Grant
Role Lead
Funding Start 1993
Funding Finish 1993
GNo G0174385
Type Of Funding Internal
Category INTE
UON Y

19922 grants / $317,024

92,93,94GRANT. The Regulation Of Protein Phosphatases In The Brain$183,006

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Alistair Sim, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas
Scheme Project Grant
Role Investigator
Funding Start 1992
Funding Finish 1992
GNo G0174274
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

The Role Of Inositol (1,4,5) Trisphosphate In The Adrenal Chromaffin Cell$134,018

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Dr Stephen Bunn, Emeritus Professor Peter Dunkley
Scheme Project Grant
Role Investigator
Funding Start 1992
Funding Finish 1992
GNo G0174260
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

19912 grants / $83,378

Calmodulin Kinases: Roles in Hormone and Neurotransmitter Release.$45,826

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Emeritus Professor Peter Dunkley
Scheme Project Grant
Role Lead
Funding Start 1991
Funding Finish 1991
GNo G0173950
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Beta Scintillation Spectrometer$37,552

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor David Powis, Emeritus Professor Peter Dunkley, Emeritus Professor John Rostas, Emeritus Professor Anthony Smith
Scheme Equipment Grant
Role Investigator
Funding Start 1991
Funding Finish 1991
GNo G0173965
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y
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Research Supervision

Number of supervisions

Completed17
Current2

Total current UON EFTSL

PhD0.4

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2015 PhD Role of Inflammation in Parkinson's Disease
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2007 Honours Catecholamine binding sites on tyrosine hydroxylase
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2015 PhD Regulation of Tyrosine Hydroxylase in Stress and Parkinson's Disease
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2013 PhD Investigation of Catecholamine Inhibition in Tyrosine Hydroxylase
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2012 PhD Neurobiological Consequences of Stress: Tyrosine Hydroxylase Phosphorylation in Response to Stress
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2012 PhD Dopaminergic Pathway Imbalance in the Neurobiology of Depression
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2010 PhD Differential Distribution of Tyrosine Hydroxylase Isoforms and Phosphorylation in Parkinson Disease
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2009 PhD Acute Regulation of Tyrosine Hydroxylase
Medical Science, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2005 Honours The effects of antidepressant drugs on catecholamine synthesis
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor
2004 Honours A model for the sustained activation of tyrosine hydroxylase
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor
2004 Honours Catecholamine binding sites in tyrosine hydroxylase
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor
2003 Honours Regulation of tyrosine hydroxylase phosphorylation by Angiotensin II
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor
2002 Honours The regulation of tyrosine hydroxylase
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor
2001 PhD Characterisation of tyrosine hydroxylase phosphorylation by mass spectrosopy
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor
2000 Honours The control of tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells
Biochemistry & Cell Biology, University of Newcastle
Sole Supervisor
1999 Masters The regulation of phospholipase c1 in bovine adrenal chromaffin cells
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor
1999 PhD Angiotensin II-stimulated tyrosine hydroxylase activity and phosphorylation in bovine adrenal chromaffin cells
Biochemistry & Cell Biology, University of Newcastle
Sole Supervisor
1997 PhD Vitamin A deficiency and intestinal structure and function in the rat
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor
1996 PhD Embryo-fetotoxicity of prenatal alcohol exposure and its relationship to oxidative stress
Biochemistry & Cell Biology, University of Newcastle
Co-Supervisor
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Emeritus Professor Peter Dunkley

Positions

Emeritus Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

One Off - Casual Lecturer
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Medical Biochemistry

Contact Details

Email peter.dunkley@newcastle.edu.au
Phone (02) 4921 5600
Fax (02) 4921 6903

Office

Room MSB506
Building Medical Sciences Building
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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