Staff Profile

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Career Summary

Biography

I produced 3 peer-reviewed papers during my postgraduate term. One of them, "BRIP1PALB2, and RAD51C mutation analysis reveals their relative importance as genetic susceptibility factors for breast cancer" was one of the early publications to show that PALB2 germline mutations are involved in the genetic predisposition to famlial breast cancer, and has ben cited 35 times to date, including by other high-impact publications.

The most notable achievements in my academic career was being awarded the HMRI PhD Student Conference Award, the HMRI Research Higher Degree Support Grant in Medical Innovation and receiving the Faculty Medal from the Faculty of Health for graduating with Honours Class I with excellent undergraduate results.

I am also keen on community involvement, as evident by my participation in various HMRI initiatives. I believe in the importance of creating awareness in the general public about the research being conducted at HMRI. 

Qualifications

  • Doctor of Philosophy, University of Newcastle, 13/02/2014
  • Bachelor of Biomedical Sciences, University of Newcastle, 13/07/2007
  • Bachelor of Biomedical Sciences (Hons), University of Newcastle, 11/07/2008

Research

Research keywords

  • Breast Cancer
  • Clinical Genetics
  • Genetics

Research expertise

One of my research strengths is in gene sequencing, from primer design to sequencing analysis. I gained this knowledge during my secondment to the Division of Molecular Genetics at Hunter Area Pathology Service (HAPS). I am currently assisting two undergraduate students with their placement project involving sequencing of several genes involved in cancer.

Languages

  • English
  • Malay

Fields of Research

CodeDescriptionPercentage
110311Medical Genetics (Excl. Cancer Genetics)70
060400Genetics20
111203Cancer Genetics10

Collaboration

I frequently collaborate with the Molecular Genetics laboratory at Hunter Area Pathology Service, Newcastle

Teaching

Teaching keywords

  • Genetics

Teaching expertise

I have previously been a tutor for the Bioinformatics and Functional Genomics (HUBS 2409) course at the University of Newcastle.

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Highlighted Publications

For publications that are currently unpublished or in-press, details are shown in italics.

YearCitationAltmetricsLink
2011Wong-Brown M, Nordfors C, Mossman D, Pecenpetelovska G, Kiejda KA, Talseth-Palmer B, et al., 'BRIP1, PALB2, and RAD51C mutation analysis reveals their relative importance as genetic susceptibility factors for breast cancer', Breast Cancer Research and Treatment, 127 853-859 (2011) [C1]

Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (6 outputs)

YearCitationAltmetricsLink
2014Wong-Brown MW, Avery-Kiejda KA, Bowden NA, Scott RJ, 'Low prevalence of germline PALB2 mutations in Australian triple-negative breast cancer', International Journal of Cancer, 134 301-305 (2014)
2014Avery-Kiejda KA, Morten B, Wong-Brown MW, Mathe A, Scott RJ, 'The relative mRNA expression of p53 isoforms in breast cancer is associated with clinical features and outcome.', Carcinogenesis, 35 586-596 (2014)
2013Wong-Brown MW, McPhillips ML, Hipwell M, Pecenpetelovska G, Dooley S, Meldrum C, Scott RJ, 'cDNA analysis of the BRCA1 unclassified variant c.5194-12G > A', CLINICAL GENETICS, 84 505-506 (2013) [C3]
2011Kiejda KA, Wong-Brown M, Scott R, 'Genetic markers in breast cancer - How far have we come from BRCA1?', Asia-Pacific Journal of Molecular Medicine, 1 1-15 (2011) [C1]
2011Wong-Brown M, Nordfors C, Mossman D, Pecenpetelovska G, Kiejda KA, Talseth-Palmer B, et al., 'BRIP1, PALB2, and RAD51C mutation analysis reveals their relative importance as genetic susceptibility factors for breast cancer', Breast Cancer Research and Treatment, 127 853-859 (2011) [C1]
2011Zacharin M, Bajpai A, Chow CW, Catto-Smith A, Stratakis C, Wong-Brown M, Scott R, 'Gastrointestinal polyps in McCune Albright syndrome', Journal of Medical Genetics, 48 458-461 (2011) [C1]
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Conference (12 outputs)

YearCitationAltmetricsLink
2014Wong-Brown M, Scott RJ, 'Low prevalence of germline PALB2 mutations in Australian triple-negative breast cancer', Abstract booklet, Kingscliff (2014)
2013Wong-Brown M, Avery-Kiejda K, Bowden N, Scott R, 'Prevalence of BRCA1 and BRCA2 germline mutations in triple-negative breast cancer', Programme, Newcastle (2013) [E3]
2013Mathe A, Avery-Kiejda KA, Wong-Brown M, Forbes JF, Braye SG, Scott RJ, 'Integration of microRNA and gene expression profiling in triple negative breast cancer to identify possible biomarkers for metastases.', Breakthrough Breast Cancer TNBC Conference Proceedings, London, UK (2013) [E3]
2013Mathe A, Wong-Brown M, Forbes JF, Braye SG, Scott RJ, Avery-Kiejda KA, 'Identification of biomarkers for metastatic spread in triple negative breast cancer.', Translational Cancer Research Conference Abstract booklet, Newcastle, Australia (2013) [E3]
2013Mathe A, Avery-Kiejda KA, Wong-Brown MW, Forbes JF, Braye SG, Scott RJ, 'Target gene identification of microRNAs associated with lymph node metastases in triple negative breast cancer.', 25th Lorne Cancer Conference Proceedings, Lorne, VIC, Australia (2013) [E3]
2013Wong-Brown M, Li S, Wilkins M, Avery-Kiejda KA, Bowden N, Scott R, 'Targeted resequencing of BRCA1 and BRCA2 in familial breast cancer.', Kathleen Cunningham Foundation Consortium for Research into Familial Aspects of Cancer 2013 Research and Practice Proceedings, Cairns, QLD, Australia. (2013) [E3]
2012Wong-Brown M, Li S, Wilkins M, Kiejda KA, Bowden NA, Scott R, 'Targeted resequencing of BRCA1 and BRCA2 in inherited breast cancer', Cancer Research, San Antonio, Texas (2012) [E3]
2012Gleeson M, Spigelman AD, Meldrum CJ, Dooley S, Wong-Brown M, Young B, et al., 'A case of two mutations in trans in a women diagnosed with breast cancer at the age of 3+0 years', Programme. kConFab Familial Aspects of Cancer: Research & Practice 2012, Kingscliff, NSW (2012) [E3]

Co-authors: RODNEY SCOTT

2012Wong-Brown M, Li S, Wilkins M, Kiejda KA, Bowden NA, Scott R, 'Exploratory targeted resequencing of BRCA1 and BRCA2 in inherited breast cancer', Programme. kConFab Familial Aspects of Cancer: Research & Practice 2012, Kingscliff, NSW (2012) [E3]
2011Wong-Brown M, Scott R, Hibberd A, Trevillian PR, Clark D, Meldrum C, 'Measurement of Foxp3 gene expression in renal transplant recipients', Immunology and Cell Biology, Canberra, Australia (2011) [E3]

Co-authors: RODNEY SCOTT

2010Wong-Brown M, Bowden NA, Kiejda KA, Scott R, 'BRIP1 and PALB2 mutation detection in Hunter-New England familial breast cancer cohort', 27th HUGO-IABCR Congress 2010. Genomics, Biology and Breast Cancer Treatment. Programme & Abstract Book, Biopolis, Singapore (2010) [E3]
2010Wong-Brown M, Bowden NA, Forbes JF, Braye SG, Scott R, 'Microsatellite instability (I) in breast tumours', Sydney Cancer Conference 2010. Profiling Risk, Personalising Treatment and Predicting Outcomes. Conference Program and Abstract Book, Sydney, NSW (2010) [E3]
Show 9 more
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Grants and Funding

Summary

Number of grants2
Total funding$36,000

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2015 (1 grants)

Karen Brown Breast Cancer Research Travel Grant$6,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Michelle Brown
SchemeRole
Karen Brown Breast Cancer Research Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$6,00020152015
GNo:G1401509

2014 (1 grants)

Targeted next-generation sequencing of potential breast cancer susceptibility genes$30,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Michelle Brown, Professor Rodney Scott
SchemeRole
Bridging GrantChief Investigator
Total AmountFunding StartFunding Finish
$30,00020142014
GNo:G1301293
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Research Supervision

Number of current supervisions0

No Supervisions.

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Dr Michelle Brown

Work Phone(02) 4042 0321
Fax(02) 4042 0031
Email
PositionAssociate Lecturer
Centre for Information-Based Medicine
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaMedical Genetics
Office
HMRI Level 3 West,
Hunter Medical Research Institute,
Hunter Medical Research Institute
URL:www.newcastle.edu.au/profile/michelle-wong-brown