Staff Profile
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Career Summary
Biography
Dr Spratt leads the stroke translation laboratory within the school of Biomedical Sciences and Pharmacy, and also works as a clinical neurologist at John Hunter Hospital. He sees his role primarily as 'bridging the gap' in translational stroke research, with the aims of moving promising therapies from the laboratory into clinical use, and of answering those important clinical questions best addressed with laboratory research. His group is part of the Hunter Medical Research Institute Centre for Brain and Mental Health stroke stream and work closely with clinical, imaging and epidemiological researchers from this stream.
Qualifications
- PhD (Medicine Denistry & Health Sciences), University of Melbourne, 19/09/2007
- Bachelor of Medicine (Honours), University of Newcastle, 27/04/1995
- Bachelor of Medical Science (Honours), University of Newcastle, 01/05/1993
Research
Research keywords
- Clinical Science
- Enriched Environment
- Experimental Stroke
- Hypothermia
- Neurosciences
- Stroke
- intracranial pressure
Research expertise
- New stroke treatment: Hypothermia
- Intracranial Pressure and CSF flow regulation after stroke
- Leptomeningeal Collateral supply to the stroke ischaemic penumbra - potential therapeutics
- Understanding basic mechanisms of brain injury in stroke role of CaMKII
- Sonothrombolysis for acute stroke.
- Acute stroke clinical trials - new thrombolytics, new therapies for intracranial haemorrhage
- Improved patient selection for stroke therapy with advanced CT imaging
- Evaluation and translation of effective stroke rehabilitation strategies from the laboratory into the rehabilitation hospital:
- Environmental Enrichment
- Improving cardiovascular fitness
Fields of Research
| Code | Description | Percentage |
|---|---|---|
| 110904 | Neurology And Neuromuscular Diseases | 40 |
| 060805 | Animal Neurobiology | 35 |
| 060603 | Animal Physiology - Systems | 25 |
Appointments
| Health Professional Research Fellowship (Part-time) National Health & Medical Research Council (Australia) | 01/01/2007 - 01/01/2011 |
Administrative
Administrative expertise
Course Co-ordinator Yr 1 Semester 2 Medical Science
Co-chair - Stroke Stream - Priority Research Centre for Translational Neuroscience and Mental Health
Teaching
Teaching keywords
- Biomedical Sciences - Neuroscience
- Medical Physiology
- Pharmacy - Stroke
Teaching expertise
Neuroscience - Stroke
Pharmacology of Stroke
Medical Science - Physiology
Edit
- Indicates that the researcher may be seeking students for this project.Greater Charitable Foundation Fellows in Stroke Research$100,000
Enriched Environment in Rehabilitation - A Phase II Trial$80,000
Novel mechanisms of ‘Stroke-in-Progression’: Intracranial pressure elevation and collateral blood vessel failure after minor stroke$20,000
Introduction to research and scientific methods$2,000
An international comparison of systems of care, risk stratification and outcomes in TIA and minor stroke$1,149,593
Short duration hypothermia to prevent subsequent intracranial pressure rise.$429,453
A new paradigm to prevent intracranial hypertension$391,076
Experimental brain imaging to investigate novel protective mechanisms of short duration body cooling after stroke$20,000
Role of CaMKII targeting in neuronal susceptibility to excitotoxic cell death$20,000
Telemetry measurement of Intracranial Pressure in Stroke and Hypothermia$15,000
Fitness Training In Stroke Trial (FiTIST): a randomised controlled assessor blind multicentre cross-over trial$73,736
Role of CaMKII targeting in stroke susceptibility and outcome$18,200
Role of CaMKII targeting in stroke susceptibility and outcome$15,000
HMRI PhD Scholarship Travel Grant, Sponsored by Jennie Thomas$10,000
The effect of stroke on cranial compartment volumes and intracranial pressure$2,600
Testing stroke sonothrombolysis using an improved experimental model of thromboembolic stroke$81,386
Improving patient selection for acute stroke therapies - an experimental model of CT brain perfusion after stroke$50,000
The use of an enriched environment to improve recovery after stroke$20,000
Effects of therapeutic hypothermia and rewarming on intracranial pressure in experimental stroke$2,064
Improving Patient Slection of rHighley Effective Stroke Therapy$240,000
China-Australia therapeutic hypothermia in stroke (CATHS) research program: identification of diagnostic molecular markers and therapeutic targets involved in re-warming related brain injury$230,275
Environmental enrichment post stroke$46,848
Establishing Computed Tomography Perfusion (CTP) imaging in an animal stroke model$20,000
Towards better early imaging in stroke: Use of an experimental model to investigate CT brain perfusion$13,000
A randomised controlled trial of mild hypothermia in acute ischaemic stroke$117,176
Is CaMKII autophosphorylation a mechanism of endogenous neuroprotection after stroke?$14,417
Hypoxic culture chamber and low-pressure gas regulators$11,500
Translation of novel neuroprotection and stroke recovery strategies from the laboratory to the clinic$171,750
Translation of novel neuroprotection and stroke recovery strategies from laboratory to the clinic$60,000
Foundation for High Blood Pressure award.$60,000
Grants and Funding
Summary
| Number of grants | 30 |
|---|---|
| Total funding | $3,485,074 |
For project grants received where the lead institution is other than the University of Newcastle, details are shown in italics.
Click on a grant title below to expand the full details for that specific grant.
2013 (4 grants)
Greater Charitable Foundation Fellows in Stroke Research$100,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Neil Spratt, Professor Mark Parsons, Conjoint Professor Chris Levi | ||
| Scheme | Role | |
| Stroke Research Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $100,000 | 2013 | 2013 |
| GNo:G1300508 | ||
Enriched Environment in Rehabilitation - A Phase II Trial$80,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Ms Heidi Janssen, Doctor Neil Spratt, Professor Michael Nilsson | ||
| Scheme | Role | |
| Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $80,000 | 2013 | 2014 |
| GNo:G1300569 | ||
Novel mechanisms of ‘Stroke-in-Progression’: Intracranial pressure elevation and collateral blood vessel failure after minor stroke$20,000
Funding Body: National Stroke Foundation
| Project Team | ||
|---|---|---|
| Doctor Damian McLeod, Doctor Neil Spratt | ||
| Scheme | Role | |
| Research Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $20,000 | 2013 | 2013 |
| GNo:G1201084 | ||
Introduction to research and scientific methods$2,000
Funding Body: University of Gothenburg
| Project Team | ||
|---|---|---|
| Doctor Neil Spratt | ||
| Scheme | Role | |
| Masters Thesis Project | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $2,000 | 2013 | 2013 |
| GNo:G1201262 | ||
2012 (6 grants)
An international comparison of systems of care, risk stratification and outcomes in TIA and minor stroke$1,149,593
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Conjoint Professor Chris Levi, Conjoint Professor Parker Magin, Dr Daniel Lasserson, Dr Jose Valderas, Associate Professor Helen Dewey, Professor Peter Barber, Professor Peter Rothwell, Doctor Neil Spratt, Dr Dominique Cadilhac, Professor Valery Feigin | ||
| Scheme | Role | |
| Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $1,149,593 | 2012 | 2016 |
| GNo:G1100258 | ||
Short duration hypothermia to prevent subsequent intracranial pressure rise.$429,453
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Doctor Neil Spratt | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $429,453 | 2012 | 2014 |
| GNo:G1100422 | ||
A new paradigm to prevent intracranial hypertension$391,076
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Doctor Neil Spratt | ||
| Scheme | Role | |
| Career Development Fellowships | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $391,076 | 2012 | 2015 |
| GNo:G1100407 | ||
Experimental brain imaging to investigate novel protective mechanisms of short duration body cooling after stroke$20,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Damian McLeod, Doctor Neil Spratt, Professor Mark Parsons, Conjoint Professor Chris Levi | ||
| Scheme | Role | |
| Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $20,000 | 2012 | 2013 |
| GNo:G1101116 | ||
Role of CaMKII targeting in neuronal susceptibility to excitotoxic cell death$20,000
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor John Rostas, Doctor Neil Spratt, Associate Professor Phillip Dickson, Doctor Nikki Verrills | ||
| Scheme | Role | |
| Near Miss Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $20,000 | 2012 | 2012 |
| GNo:G1200673 | ||
Telemetry measurement of Intracranial Pressure in Stroke and Hypothermia$15,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Neil Spratt | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $15,000 | 2012 | 2012 |
| GNo:G1201131 | ||
2011 (5 grants)
Fitness Training In Stroke Trial (FiTIST): a randomised controlled assessor blind multicentre cross-over trial$73,736
Funding Body: National Heart Foundation of Australia
| Project Team | ||
|---|---|---|
| Doctor Neil Spratt, Conjoint Professor Chris Levi, Professor Robin Callister | ||
| Scheme | Role | |
| Postgraduate Biomedical Research Scholarship | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $73,736 | 2011 | 2013 |
| GNo:G1000862 | ||
Role of CaMKII targeting in stroke susceptibility and outcome$18,200
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Professor John Rostas, Doctor Neil Spratt, Doctor Kathryn Skelding | ||
| Scheme | Role | |
| Stroke Research Project Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $18,200 | 2011 | 2011 |
| GNo:G1001013 | ||
Role of CaMKII targeting in stroke susceptibility and outcome$15,000
Funding Body: Brain Foundation (NSW Branch)
| Project Team | ||
|---|---|---|
| Doctor Neil Spratt, Professor John Rostas | ||
| Scheme | Role | |
| Research Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $15,000 | 2011 | 2011 |
| GNo:G1000716 | ||
HMRI PhD Scholarship Travel Grant, Sponsored by Jennie Thomas$10,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Neil Spratt, Ms Amelia Tomkins | ||
| Scheme | Role | |
| Research Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $10,000 | 2011 | 2012 |
| GNo:G1100898 | ||
The effect of stroke on cranial compartment volumes and intracranial pressure$2,600
Funding Body: National Stroke Foundation
| Project Team | ||
|---|---|---|
| Doctor Damian McLeod, Doctor Neil Spratt | ||
| Scheme | Role | |
| Research Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $2,600 | 2011 | 2011 |
| GNo:G1100727 | ||
2010 (4 grants)
Testing stroke sonothrombolysis using an improved experimental model of thromboembolic stroke$81,386
Funding Body: National Stroke Foundation
| Project Team | ||
|---|---|---|
| Doctor Neil Spratt, Conjoint Professor Chris Levi | ||
| Scheme | Role | |
| Postgraduate Biomedical Scholarship | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $81,386 | 2010 | 2013 |
| GNo:G0190597 | ||
Improving patient selection for acute stroke therapies - an experimental model of CT brain perfusion after stroke$50,000
Funding Body: BellBerry Limited
| Project Team | ||
|---|---|---|
| Professor Mark Parsons, Doctor Neil Spratt, Conjoint Professor Chris Levi, Doctor Damian McLeod, Dr Peter Stanwell | ||
| Scheme | Role | |
| Near Miss | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $50,000 | 2010 | 2012 |
| GNo:G0900222 | ||
The use of an enriched environment to improve recovery after stroke$20,000
Funding Body: National Stroke Foundation
| Project Team | ||
|---|---|---|
| Doctor Neil Spratt | ||
| Scheme | Role | |
| Research Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $20,000 | 2010 | 2010 |
| GNo:G1000381 | ||
Effects of therapeutic hypothermia and rewarming on intracranial pressure in experimental stroke$2,064
Funding Body: National Stroke Foundation
| Project Team | ||
|---|---|---|
| Doctor Damian McLeod, Doctor Neil Spratt, Professor Mike Calford | ||
| Scheme | Role | |
| Honours Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $2,064 | 2010 | 2011 |
| GNo:G1000608 | ||
2009 (5 grants)
Improving Patient Slection of rHighley Effective Stroke Therapy$240,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Neil Spratt | ||
| Scheme | Role | |
| Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $240,000 | 2009 | 2012 |
| GNo:G0190535 | ||
China-Australia therapeutic hypothermia in stroke (CATHS) research program: identification of diagnostic molecular markers and therapeutic targets involved in re-warming related brain injury$230,275
Funding Body: NSW Office for Science & Medical Research
| Project Team | ||
|---|---|---|
| Conjoint Professor Chris Levi, Doctor Mark Baker, Doctor Neil Spratt, Professor John Rostas | ||
| Scheme | Role | |
| China-NSW Collaborative Research Program | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $230,275 | 2009 | 2009 |
| GNo:G0190392 | ||
Environmental enrichment post stroke$46,848
Funding Body: National Stroke Foundation
| Project Team | ||
|---|---|---|
| Doctor Neil Spratt | ||
| Scheme | Role | |
| Research Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $46,848 | 2009 | 2012 |
| GNo:G1000541 | ||
Establishing Computed Tomography Perfusion (CTP) imaging in an animal stroke model$20,000
Funding Body: National Stroke Foundation
| Project Team | ||
|---|---|---|
| Doctor Damian McLeod, Doctor Neil Spratt, Professor Mike Calford, Conjoint Professor Chris Levi, Professor Mark Parsons | ||
| Scheme | Role | |
| Research Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $20,000 | 2009 | 2009 |
| GNo:G0189942 | ||
Towards better early imaging in stroke: Use of an experimental model to investigate CT brain perfusion$13,000
Funding Body: Hunter Medical Research Institute
| Project Team | ||
|---|---|---|
| Doctor Neil Spratt, Professor Mark Parsons, Doctor Damian McLeod, Conjoint Professor Chris Levi | ||
| Scheme | Role | |
| Stroke Research Project Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $13,000 | 2009 | 2009 |
| GNo:G0189810 | ||
2008 (3 grants)
A randomised controlled trial of mild hypothermia in acute ischaemic stroke$117,176
Funding Body: National Heart Foundation of Australia
| Project Team | ||
|---|---|---|
| Conjoint Professor Chris Levi, Professor Mark Parsons, Dr C Bladin, Doctor Neil Spratt | ||
| Scheme | Role | |
| Grant-In-Aid | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $117,176 | 2008 | 2009 |
| GNo:G0187644 | ||
Is CaMKII autophosphorylation a mechanism of endogenous neuroprotection after stroke?$14,417
Funding Body: University of Newcastle
| Project Team | ||
|---|---|---|
| Professor John Rostas, Doctor Neil Spratt | ||
| Scheme | Role | |
| Pilot Grant | Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $14,417 | 2008 | 2008 |
| GNo:G0189110 | ||
Hypoxic culture chamber and low-pressure gas regulators$11,500
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Doctor Neil Spratt, Professor John Rostas, Professor Mike Calford | ||
| Scheme | Role | |
| Equipment Grant | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $11,500 | 2008 | 2008 |
| GNo:G0188544 | ||
2007 (2 grants)
Translation of novel neuroprotection and stroke recovery strategies from the laboratory to the clinic$171,750
Funding Body: NHMRC (National Health & Medical Research Council)
| Project Team | ||
|---|---|---|
| Doctor Neil Spratt | ||
| Scheme | Role | |
| Training (Postdoctoral) Fellowships - Health Professional Research Fellowship (Part-time) | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $171,750 | 2007 | 2011 |
| GNo:G0186772 | ||
Translation of novel neuroprotection and stroke recovery strategies from laboratory to the clinic$60,000
Funding Body: Sylvia & Charles Viertel Charitable Foundation
| Project Team | ||
|---|---|---|
| Doctor Neil Spratt | ||
| Scheme | Role | |
| Medical Program - Viertel Clinical Investigators | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $60,000 | 2007 | 2008 |
| GNo:G0187573 | ||
2006 (1 grants)
Foundation for High Blood Pressure award.$60,000
Funding Body: Royal Australasian College of Physicians
| Project Team | ||
|---|---|---|
| Doctor Neil Spratt | ||
| Scheme | Role | |
| Research and Education Foundation | Chief Investigator | |
| Total Amount | Funding Start | Funding Finish |
| $60,000 | 2006 | 2006 |
| GNo:G0187214 | ||
Edit
Research Supervision
| Number of current supervisions | 6 |
|---|---|
| Total current UoN PhD EFTSL | 3.9 |
For supervisions undertaken at an institution other that the University of Newcastle, details are shown in italics, and the institution name is listed below the program name.
Current Supervision
| Commenced | Proposed Completion | Program | Supervisor Type | Research Title |
|---|---|---|---|---|
| 2012 | 2016 | PhD (Physiotherapy) | Co-Supervisor | Prevention of Stroke Through Improving Fitness |
| 2011 | 2015 | PhD (Human Physiology) | Principal Supervisor | The Effects and Mechanisms of Therapeutic Hypothermia on Intracranial Pressure following Ischaemic Stroke in Rats |
| 2011 | 2015 | PhD (Human Physiology) | Principal Supervisor | Increasing Perfusion to Ischaemic Brain Through Ieptomeningeal Collaterals: A Potential New Treatment For Stroke |
| 2011 | 2015 | PhD (Medicine) | Principal Supervisor | Fitness Training in Stroke Trial |
| 2010 | 2014 | PhD (Human Physiology) | Principal Supervisor | Testing Stroke Sonothrombolysis Using an Improved Experimental Model of Thromboembolic Stroke |
| 2009 | 2013 | PhD (Human Physiology) | Principal Supervisor | Use of an Enriched Environment Post-Stroke: Translating from Bench to Bedside |
Edit
Dr Neil Spratt
| Work Phone | (02) 4921 6171 |
|---|---|
| Cell / Mobile Phone | 0403363981 |
| Fax | (02) 4921 7406 |
| Neil.Spratt@newcastle.edu.au | |
| Position | Senior Lectuer School of Biomedical Sciences and Pharmacy Faculty of Health and Medicine |
| Focus Area | Human Physiology |
| Office | MS502a, Medical Sciences , Callaghan University Drive Callaghan NSW 2308 Australia |
| URL: | www.newcastle.edu.au/profile/neil-spratt |
