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Career Summary

Qualifications

  • PhD (Human Physiology), University of Newcastle, 13/03/2008
  • Bachelor of Biomedical Sciences (Hons), University of Newcastle, 15/12/2003

Research

Research keywords

  • Clinical Science
  • Medical Physiology
  • Stroke

Research expertise

  • Stroke / cerebral ischaemia
  • Imaging the ischaemic penumbra using perfusion computed tomography (CTP)
  • Improving outcome and safety for thrombolysis in stroke
  • Mechanisms of hypothermic neuroprotection following ischaemic stroke
  • Effects of therapeutic hypothermia on intracranial pressure following stroke
  • Proteomic changes following stroke and therapeutic hypothermia
  • Cardiovascular and respiratory physiology
  • Neural control of the bronchial circulation during exercise
  • Exercise-induced asthma

Fields of Research

CodeDescriptionPercentage
110300Clinical Sciences100
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Journal article (15 outputs)

YearCitationAltmetricsLink
2014Spratt NJ, Tomkins AJ, Pepperall D, McLeod DD, Calford MB, 'Allopregnanolone and Its Precursor Progesterone Do Not Reduce Injury after Experimental Stroke in Hypertensive Rats - Role of Postoperative Temperature Regulation?', PLoS One, 9 e107752 (2014)
2014Murtha LA, Mcleod DD, Mccann SK, Pepperall D, Chung S, Levi CR, et al., 'Short-duration hypothermia after ischemic stroke prevents delayed intracranial pressure rise', International Journal of Stroke, 9 553-559 (2014)
2014Murtha LA, Yang Q, Parsons MW, Levi CR, Beard DJ, Spratt NJ, McLeod DD, 'Cerebrospinal fluid is drained primarily via the spinal canal and olfactory route in young and aged spontaneously hypertensive rats.', Fluids Barriers CNS, 11 12 (2014)
2013McLeod DD, Beard DJ, Parsons MW, Levi CR, Calford MB, Spratt NJ, 'Inadvertent Occlusion of the Anterior Choroidal Artery Explains Infarct Variability in the Middle Cerebral Artery Thread Occlusion Stroke Model', PLoS ONE, 8 (2013) [C1]
2013Mcleod DD, Hood R, Hiles B, Allen J, Mccann SK, Murtha L, et al., 'Perfusion computed tomography thresholds defining ischemic penumbra and infarct core: Studies in a rat stroke model', International Journal of Stroke, (2013)
2013Murtha LA, Mcleod DD, Mccann SK, Pepperall D, Chung S, Levi CR, et al., 'Short-duration hypothermia after ischemic stroke prevents delayed intracranial pressure rise', International Journal of Stroke, (2013)
2012McLeod DD, Parsons G, Gunther R, Quail AW, Cottee DB, White SW, 'Differential effects of inhaled methacholine on circumferential wall and vascular smooth muscle of third-generation airways in awake sheep', Journal of Applied Physiology, 113 1233-1242 (2012) [C1]

Co-authors: Saxon White, Tony Quail

2011McLeod DD, Parsons MW, Levi CR, Beautement S, Buxton D, Roworth B, Spratt NJ, 'Establishing a rodent stroke perfusion computed tomography model', International Journal of Stroke, 6 284-289 (2011) [C1]
2011McIlveen SA, White SW, Quail AW, McLeod DD, Parsons G, 'Integration of baroreflex and autoregulation control of bronchial blood flow in awake dogs', Acta Physiologica, 203 299-310 (2011) [C1]

Co-authors: Saxon White, Tony Quail

2011Spratt NJ, Donnan GA, McLeod DD, Howells DW, ''Salvaged' stroke ischaemic penumbra shows significant injury: Studies with the hypoxia tracer FMISO', Journal of Cerebral Blood Flow and Metabolism, 31 934-943 (2011) [C1]
2007Parsons G, White SW, Quail AW, McIlveen SA, Bishop R, McLeod DD, et al., 'Autonomic control of bronchial blood flow and airway dimensions during strenuous exercise in sheep', Pulmonary Pharmacology & Therapeutics, 20 190-199 (2007) [C1]
2007Bishop R, McLeod DD, McIlveen SA, Blake RJ, Gunther R, Davis J, et al., 'Effects of graded exercise on bronchial blood flow and airway dimensions in sheep', Pulmonary Pharmacology & Therapeutics, 20 178-189 (2007) [C1]
2003White SW, McIlveen SA, Parsons G, Quail AW, Cottee DB, Gunther R, et al., 'Neural Control of the Bronchial Circulation', Archives of the Physiology and Biochemistry, 111 305-308 (2003) [C1]
2003Quail AW, Cottee DB, McLeod DD, Blake RJ, Bishop R, McIlveen SA, White SW, 'Analysis of Bronchovascular Downstream Blood Pressure Changes in Exercising Sheep', Archives of Physiology and Biochemistry, 111 309-313 (2003) [C1]
2003Bishop R, McLeod DD, McIlveen SA, Blake RJ, Gunther R, Davis J, et al., 'Long-Term Measurement of Bronchial Vascular Resistance in Awake Sheep and Dogs', Archives of Physiology and Biochemistry, 111 315-315 (2003) [C1]
Show 12 more

Conference (31 outputs)

YearCitationAltmetricsLink
2013Beard D, McLeod D, Spratt N, 'The collateral circulation: key to outcome in mice and men', INTERNATIONAL JOURNAL OF STROKE (2013) [E3]
2012White SW, McLeod DD, Parsons G, Gunther R, Cottee DB, Quail AW, 'Selective effects of inhaled methacholine on 3rd generation bronchial blood flow and airway dimensions in awake sheep', FASEB Journal, San Diego, CA (2012) [E3]

Co-authors: Saxon White, Tony Quail

2012Murtha LA, McLeod DD, Spratt NJ, 'The effects of therapeutic hypothermia on intracranial pressure after experimental ischemic stroke', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]

Co-authors: Neil Spratt

2012Quail AW, Cottee DB, McLeod DD, Hamut M, White SW, 'Comparative effects of isoflurane, sevoflurane and desflurane on resting airway dimensions in the sheep', ANZCA ASM 2012. Evolution: Grow Develop Thrive: ePoster Sessions 2012, Perth, WA (2012) [E3]

Co-authors: Saxon White, Tony Quail

2012McLeod DD, Beard DJ, Imtiaz MS, Spratt NJ, 'Validating a novel method for measuring leptomeningeal collateral flow in experimental stroke', The Stroke Interventionalist, Los Angeles, CA (2012) [E3]

Co-authors: Neil Spratt

2012Arulampalam A, McLeod DD, Spratt NJ, 'Fluid shifts in the rat brain after ischaemic stroke', Abstracts. Australian Neuroscience Society 32nd Annual Meeting, Gold Coast, Queensland (2012) [E3]

Co-authors: Neil Spratt

2012McLeod DD, Murtha LA, Pitsillides K, 'A new method of attaching a solid-state pressure sensor for measurement of chronic intracranial pressure in freely moving rats using biotelemetry', FASEB Journal, San Diego, CA (2012) [E3]
2012Beard DJ, McLeod DD, Imtiaz MS, Spratt NJ, 'Quantitative assessment of leptomeningeal collateral flow in experimental stroke', The Stroke Interventionalist, Los Angeles, CA (2012) [E3]

Co-authors: Neil Spratt

2011White SW, McLeod DD, Parsons GH, Gunther RA, Cottee DB, Quail AW, 'Inhaled and intravenous methacholine evoke differential effects on bronchial blood flow and 3rd generation airway dimensions in awake sheep', Proceedings of the Australian Physiological Society 2011, Perth (2011) [E3]

Co-authors: Saxon White, Tony Quail

2011Murtha LA, McLeod DD, McCann S, Pepperall D-G, Spratt NJ, 'Short duration hypothermia results in sustained prevention of intracranial pressure elevation following experimental stroke', International Journal of Stroke, Adelaide, SA (2011) [E3]

Co-authors: Neil Spratt

2011Hamut M, Quail AW, Seah PW, McLeod DD, Cottee DB, White SW, 'Mammalian differences in vagal-cholinoceptor control of coronary conductance', The FASEB journal, Washington, DC (2011) [E3]

Co-authors: Saxon White, Tony Quail

2009McLeod DD, 'Evaluation of a modified airways internal diameter assessment: Sonomicrometer for analysis of third generation airway reflexes in anesthetized and awake sheep', ISAN Satellite Meeting. Autonomic Adjustments to Environmental Challenges. Final Program, Newcastle, NSW (2009) [E3]
2009McLeod DD, Spratt NJ, Levi CR, Beautement S, Roworth B, Buxton D, et al., 'Perfusion computed tomography for acute stroke: A model for experimental validation', Cerebrovascular Diseases, Stockholm, Sweden (2009) [E3]
2009McLeod DD, Spratt NJ, Levi CR, Beautement S, Roworth B, Buxton D, et al., 'Experimental validation of perfusion computed tomography in acute middle cerebral artery occlusion', ACBRC 2009 Abstracts, Tianjin, China (2009) [E3]
2009McLeod DD, Parsons MW, Levi CR, Beautement S, Roworth B, Buxton D, et al., 'An experimental model to investigate CT brain perfusion after stroke', ANS 2009 Abstracts: Posters, Canberra, ACT (2009) [E3]
2008McLeod DD, Gunther R, Seah PW, Quail AW, Cottee DB, Parsons G, White SW, 'Integrated autonomic control of the bronchial circulation and 3rd generation bronchus in the exercising sheep', American Journal of Respiratory and Critical Care Medicine, Toronto, ONT (2008) [E3]

Co-authors: Saxon White, Tony Quail

2008Hamut M, Quail AW, Cottee DB, Seah PW, McLeod DD, Blake RJ, White SW, 'Effects of evoked acute and steady-state high blood pressure on control of right and left coronary blood flow and conductance in awake sheep', Journal of Hypertension, Berlin, Germany (2008) [E3]

Co-authors: Saxon White, Tony Quail

2007Quail AW, Cottee DB, Seah PW, McLeod DD, Blake RJ, White SW, 'Evolutionary aspects of neural control of coronary blood flow', Proceedings of the Australian Physiological Society, Newcastle, N.S.W. (2007) [E3]

Co-authors: Saxon White, Tony Quail

2007Hamut M, Quail AW, Cottee DB, Seah PW, McLeod DD, Blake RJ, White SW, 'Baroreflex-autonomic control of regional coronary blood flow conductance in awake sheep', Proceedings of the Australian Physiological Society, Newcastle, N.S.W. (2007) [E3]

Co-authors: Saxon White, Tony Quail

2007White SW, Parsons G, MacTaggart G, McLeod DD, Hamut M, Cottee DB, Quail AW, 'Controversy: Exercise-induced pulmonary haemorrhage in the horse', Proceedings of the Australian Physiological Society, Newcastle, N.S.W. (2007) [E3]

Co-authors: Saxon White, Tony Quail

2007Robinson S, McLeod DD, Gunther R, Quail AW, White SW, Parsons G, 'High frequency oscillatory ventilation (HFOV) effects on airway blood flow and airway caliber in sheep', American Journal of Respiratory and Critical Care Medicine, San Francisco, Calif. (2007) [E3]

Co-authors: Saxon White, Tony Quail

2007McLeod DD, Gunther R, Seah PW, Quail AW, Cottee DB, Parsons G, White SW, 'Integrated autonomic control of the bronchial circulation and 3rd generation airway dimensions during exercise in awake sheep', Proceedings of the Australian Physiological Society, Newcastle, N.S.W. (2007) [E3]

Co-authors: Saxon White, Tony Quail

2007McLeod DD, Robinson S, Gunther R, Quail AW, Cottee DB, Seah P, et al., 'Effects of graded PEEP on bronchial blood flow and dimensions', American Journal of Respiratory and Critical Care Medicine, San Francisco, Calif. (2007) [E3]

Co-authors: Saxon White, Tony Quail

2006Hamut M, Quail AW, Cottee DB, Seah PW, Blake RJ, White SW, et al., 'Development of a chronic sheepp model for the study of regional coronary control mechanisms', Experimental Biology 2006: Meeting Abstracts, San Francisco (2006) [E3]

Co-authors: Saxon White, Tony Quail

2006White SW, McLeod DD, McIlveen SA, Bishop R, Gunther R, Cottee DB, Parsons G, 'Autonomic control of bronchial blood flow, airway circumference and airway wall thickness during strenuous exercise in sheep (Poster presentation)', Abstracts of the Experimental Biology 2006 Meeting (FASEB Journal vol 20, no 5), San Francisco, CA (2006) [E3]

Co-authors: Saxon White

2006McLeod DD, Bastian F, Parsons G, Gunther R, Quail AW, Cottee DB, White SW, 'Graded exercise evokes bronchovascular and lower airway smooth muscle constriction', Abstracts from AuPS/Combio Brisbane 2006 (Proceedings of the Australian Physiological Society Vol 37), Brisbane (2006) [E3]

Co-authors: Saxon White, Tony Quail

2006White SW, McLeod DD, Parsons G, Gunther R, McIlveen SA, Bishop R, et al., 'Autonomic control of airways vascular and wall smooth muscle during exercise', Proceedings of the Australian Physiological Society, Brisbane (2006) [E3]

Co-authors: Saxon White, Tony Quail

2006McLeod DD, Parsons G, Bishop R, McIlveen SA, Gunther R, Cottee DB, et al., 'Effects of graded exercise on bronchial blood flow and airway dimensions in sheep', Experimental Biology 2006: Meeting Abstracts, San Francisco (2006) [E3]

Co-authors: Saxon White, Tony Quail

2005McLeod DD, Parsons G, Gunther R, McIlveen SA, Bishop R, White SW, et al., 'Neural factors controlling bronchial blood flow during exercise', The FASEB Journal, San Diego, USA (2005) [E3]

Co-authors: Saxon White, Tony Quail

2004Quail AW, Cottee DB, McLeod DD, Blake RJ, Bishop R, McIlveen SA, et al., 'Neural and pressure gradient factors controlling bronchial blood flow in exercising sheep', -, Royal North Shore Hospital, Sydney (2004) [E1]

Co-authors: Saxon White, Tony Quail

2004White SW, McIlveen SA, Bishop R, McLeod DD, Blake RJ, Gunther R, et al., 'Mechanisms controlling airways circulation during exercise', Proccedings of the Australian Health and Medical Research Congress 2004, Sydney (2004) [E3]

Co-authors: Saxon White, Tony Quail

Show 28 more
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Grants and Funding

Summary

Number of grants12
Total funding$153,139

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2014 (1 grants)

Cooling the brain via the skin to prevent intracranial pressure elevation after stroke$19,275
Funding Body: National Stroke Foundation

Project Team
Doctor Damian McLeod, Doctor Neil Spratt
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$19,27520142014
GNo:G1301145

2013 (2 grants)

Novel mechanisms of ‘Stroke-in-Progression’: Intracranial pressure elevation and collateral blood vessel failure after minor stroke$20,000
Funding Body: National Stroke Foundation

Project Team
Doctor Damian McLeod, Doctor Neil Spratt
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020132013
GNo:G1201084

The XXVth International Symposium on Cerebral Blood flow, Metabolism and function & XIth International Conference on Quantification of Brain Function with PET, Shanghai, China, 20 - 23 May 2013$1,500
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Damian McLeod
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,50020132013
GNo:G1300541

2012 (2 grants)

Experimental brain imaging to investigate novel protective mechanisms of short duration body cooling after stroke$20,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Damian McLeod, Doctor Neil Spratt, Professor Mark Parsons, Conjoint Professor Chris Levi
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020122012
GNo:G1101116

International Symposium of Collaterals to the Brain, Los Angeles, California, USA, 6 - 8 November 2012$1,500
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Damian McLeod
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,50020122012
GNo:G1200951

2011 (2 grants)

The effect of stroke on cranial compartment volumes and intracranial pressure$2,600
Funding Body: National Stroke Foundation

Project Team
Doctor Damian McLeod, Doctor Neil Spratt
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,60020112011
GNo:G1100727

XXVth International Symposium on Cerebral Blood Flow, Metabolism and Function and the Xth International Conference on Quantification of Brain Function with PET$1,500
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Damian McLeod
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,50020112011
GNo:G1100304

2010 (2 grants)

Improving patient selection for acute stroke therapies - an experimental model of CT brain perfusion after stroke$50,000
Funding Body: BellBerry Limited

Project Team
Professor Mark Parsons, Doctor Neil Spratt, Conjoint Professor Chris Levi, Doctor Damian McLeod, Dr Peter Stanwell
SchemeRole
Near MissInvestigator
Total AmountFunding StartFunding Finish
$50,00020102012
GNo:G0900222

Effects of therapeutic hypothermia and rewarming on intracranial pressure in experimental stroke$2,064
Funding Body: National Stroke Foundation

Project Team
Doctor Damian McLeod, Doctor Neil Spratt, Professor Mike Calford
SchemeRole
Honours GrantChief Investigator
Total AmountFunding StartFunding Finish
$2,06420102010
GNo:G1000608

2009 (3 grants)

Establishing Computed Tomography Perfusion (CTP) imaging in an animal stroke model$20,000
Funding Body: National Stroke Foundation

Project Team
Doctor Damian McLeod, Doctor Neil Spratt, Professor Mike Calford, Conjoint Professor Chris Levi, Professor Mark Parsons
SchemeRole
Research GrantChief Investigator
Total AmountFunding StartFunding Finish
$20,00020092009
GNo:G0189942

Towards better early imaging in stroke: Use of an experimental model to investigate CT brain perfusion$13,000
Funding Body: Hunter Medical Research Institute

Project Team
Doctor Neil Spratt, Professor Mark Parsons, Doctor Damian McLeod, Conjoint Professor Chris Levi
SchemeRole
Stroke Research Project GrantInvestigator
Total AmountFunding StartFunding Finish
$13,00020092009
GNo:G0189810

XVII European Stroke Conference, Stockholm Sweden, 26-29 May 2009$1,700
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Doctor Damian McLeod
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,70020092009
GNo:G0190140
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Research Supervision

Number of current supervisions2
Total current UoN PhD EFTSL0.3

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20112015PhD (Human Physiology)Co-SupervisorThe Effects and Mechanisms of Therapeutic Hypothermia on Intracranial Pressure Regulation Following Ischaemic Stroke in Rats
20112015PhD (Human Physiology)Co-SupervisorIncreasing Perfusion to Ischaemic Brain Through Ieptomeningeal Collaterals: A Potential New Treatment For Stroke
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Dr Damian McLeod

Work Phone(02) 4921 7856
Fax(02) 4921 7903
Email
PositionPostdoctoral Fellow
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaHuman Physiology
Office
MS503,
Medical Sciences,
Callaghan
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/damian-mcleod