Dr Olivia Wynne

Research Assistant

School of Nursing and Midwifery

Career Summary

Biography

Research Expertise
My previous research focus was in the area of psychoneuroendocrinology, specifically the effect of early life infection on adult functioning. One particular interest was the influence of sex on health outcomes. Currently, my research work focuses on mental health with an interest on quality of life interventions for people living with dementia and people living with schizophrenia. Also of interest is the influence of gender on mental health and help seeking.

Qualifications

  • PhD, University of Newcastle

Keywords

  • Biological Psychology
  • Gender
  • Mental Health
  • Psychology

Fields of Research

Code Description Percentage
111714 Mental Health 40
170105 Gender Psychology 40
170199 Psychology not elsewhere classified 20

Professional Experience

Academic appointment

Dates Title Organisation / Department
1/04/2013 - 1/09/2013 Safety Officer University of Newcastle
Faculty of Science and Information Technology
Australia
1/09/2011 - 1/11/2012 Postdoctoral Associate Rutgers, The State University of New Jersey
Endocrinology
United States
1/03/2005 - 1/06/2011 Casual Lecturer University of Newcastle
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

Year Citation Altmetrics Link
2013 Wynne OL, Sarkar DK, 'Stress and Neuroendocrine¿Immune Interaction: A Therapeutic Role for Beta-endorphin', The Wiley-Blackwell Handbook of Psychoneuroimmunology, John Wiley & Sons, London 198-211 (2013)

Journal article (6 outputs)

Year Citation Altmetrics Link
2015 Logan RW, Wynne O, Maglakelidze G, Zhang C, O'Connell S, Boyadjieva NI, Sarkar DK, 'beta-Endorphin Neuronal Transplantation Into the Hypothalamus Alters Anxiety-Like Behaviors in Prenatal Alcohol-Exposed Rats and Alcohol-Non-Preferring and Alcohol-Preferring Rats', ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH, 39 146-157 (2015)
DOI 10.1111/acer.12611
2015 Gangisetty O, Wynne O, Jabbar S, Nasello C, Sarkar DK, 'Fetal alcohol exposure reduces dopamine receptor d2 and increases pituitary weight and prolactin production via epigenetic mechanisms', PLoS ONE, 10 (2015)

© 2015 Gangisetty et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and... [more]

© 2015 Gangisetty et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Recent evidence indicated that alcohol exposure during the fetal period increases the susceptibility to tumor development in mammary and prostate tissues. Whether fetal alcohol exposure increases the susceptibility to prolactin-producing tumor (prolactinoma) development in the pituitary was studied by employing the animal model of estradiol-induced prolactinomas in Fischer 344 female rats. We employed an animal model of fetal alcohol exposure that simulates binge alcohol drinking during the first two trimesters of human pregnancy and involves feeding pregnant rats with a liquid diet containing 6.7% alcohol during gestational day 7 to day 21. Control rats were pair-fed with isocaloric liquid diet or fed ad libitum with rat chow diet. Adult alcohol exposed and control female offspring rats were used in this study on the day of estrus or after estrogen treatment. Results show that fetal alcoholexposed rats had increased levels of pituitary weight, pituitary prolactin (PRL) protein and mRNA, and plasma PRL. However, these rats show decreased pituitary levels of dopamine D2 receptor (D2R) mRNA and protein and increased pituitary levels of D2R promoter methylation. Also, they show elevated pituitary mRNA levels of DNA methylating genes (DNMT1, DNMT3b, MeCP2) and histone modifying genes (HDAC2, HDAC4, G9a). When fetal alcohol exposed rats were treated neonatally with a DNA methylation inhibitor 5-Aza deoxycytidine and/or a HDAC inhibitor trichostatin-A their pituitary D2R mRNA, pituitary weights and plasma PRL levels were normalized. These data suggest that fetal alcohol exposure programs the pituitary to increase the susceptibility to the development of prolactinomas possibly by enhancing the methylation of the D2R gene promoter and repressing the synthesis and control of D2R on PRL-producing cells.

DOI 10.1371/journal.pone.0140699
2013 Logan RW, Wynne O, Levitt D, Price D, Sarkar DK, 'Altered Circadian Expression of Cytokines and Cytolytic Factors in Splenic Natural Killer Cells of Per1(-/-) Mutant Mice', JOURNAL OF INTERFERON AND CYTOKINE RESEARCH, 33 108-114 (2013)
DOI 10.1089/jir.2012.0092
Citations Web of Science - 10
2012 Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Effect of neonatal respiratory infection on adult BALB/c hippocampal glucocorticoid and mineralocorticoid receptors', Developmental Psychobiology, 54 568-575 (2012) [C1]
Citations Scopus - 2Web of Science - 1
Co-authors Jay Horvat, Roger Smith, Philip Hansbro, Deborah Hodgson, Vicki Clifton
2011 Wynne OL, Horvat JC, Kim RY, Ong LK, Smith R, Hansbro PM, et al., 'Neonatal respiratory infection and adult re-infection: Effect on glucocorticoid and mineralocorticoid receptors in the hippocampus in BALB/c mice', Brain Behavior and Immunity, 25 1214-1222 (2011) [C1]
DOI 10.1016/j.bbi.2011.03.014
Citations Scopus - 3Web of Science - 3
Co-authors Deborah Hodgson, Vicki Clifton, Philip Hansbro, Roger Smith, Jay Horvat, Linkooi Ong
2011 Wynne OL, Horvat JC, Osei-Kumah A, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Early life infection alters adult BALB/c hippocampal gene expression in a sex specific manner', Stress-the International Journal on the Biology of Stress, 14 247-261 (2011) [C1]
DOI 10.3109/10253890.2010.532576
Citations Scopus - 9Web of Science - 9
Co-authors Deborah Hodgson, Vicki Clifton, Philip Hansbro, Roger Smith, Jay Horvat
Show 3 more journal articles

Conference (10 outputs)

Year Citation Altmetrics Link
2014 Sarkar DK, Maglakelidze G, Wynne O, 'A COMBINED OPIATE AGONIST AND ANTAGONIST TRETMENT REDUCES PITUTARY TUMOR GROWTH IN FETAL ALCOHOL-EXPOSED RATS: A STUDY CONDUCTED BY USING MAGNETIC RESONACE IMAGING', ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2014) [E3]
2014 Sarkar DK, Zhang C, Bekdash R, Wynne O, 'TRANSGENERATIONAL EPIGENETIC EFFECTS OF FETAL ALCOHOL EXPOSURE ON THE NEUROENDOCRINE-IMMUNE AXIS', ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2014) [E3]
2013 Gangisetty O, Wynne O, Radl DB, Maglakelidze G, Sarkar DK, 'FETAL ALCOHOL EXPOSURES EPIGENETICALLY PROGRAM THE GROWTH REGULATORY MECHANISM AND INCREASE THE SUSCEPTIBILITY TO PROLACTIN-SECRETING PITUITARY TUMOR', ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2013)
Citations Web of Science - 1
2012 Logan RW, Zhang C, O'Connell S, Ortiguela M, Boyadjeiva N, Wynne O, Sarkar DK, 'BETA-ENDORPHIN NEURON TRANSPLANTATION IN THE HYPOTHALAMUS ATTENUATES CORTICOSTERONE RESPONSE AND ANXIETY-LIKE BEHAVIORS IN FETAL ALCOHOL EXPOSED RATS', ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH (2012)
2011 Wynne OL, Bromley AR, Dunstan RH, Hodgson DM, 'Prenatal LPS determines the effect of anandamide on behaviour and endocrine functions in adulthood', Brain, Behavior, and Immunity (2011) [E3]
Co-authors Hugh Dunstan, Deborah Hodgson
2008 Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal glucocorticoid receptor, mineralocorticoid receptor and corticotrophin releasing hormone mRNA abundance', Proceedings of the Australian Neuroscience Society (2008) [E3]
Co-authors Deborah Hodgson, Jay Horvat, Roger Smith, Philip Hansbro, Vicki Clifton
2008 Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal glucocorticoid receptor and mineralocorticoid receptor abundance', 15th Annual Meeting of the Psychoneuroimmunology Research Society: Program (2008) [E3]
Co-authors Vicki Clifton, Jay Horvat, Roger Smith, Philip Hansbro, Deborah Hodgson
2007 Wynne OL, Horvat JC, Smith R, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of neonatal infection on adult hippocampal corticosterone receptor abundance and circulating corticosterone', Early Human Development (2007) [E3]
Co-authors Roger Smith, Deborah Hodgson, Philip Hansbro, Jay Horvat, Vicki Clifton
2007 Wynne OL, Horvat JC, Hansbro PM, Clifton VL, Hodgson DM, 'Impact of postnatal stress on neuroendocrine development and function in adulthood in the mouse', Fetal & Neonatal Workshop of Australia and New Zealand 21st Annual Meeting. Abstracts (2007) [E3]
Co-authors Philip Hansbro, Deborah Hodgson, Jay Horvat, Vicki Clifton
2005 Wynne OL, Clifton VL, Murphy VE, Hodyl NA, Krivanek K, Smith D, et al., 'The Effects of Prenatal Endotoxin Exposure on Placental 11-HSD2 Activity and the Developing HPA Axis in the Fischer 344 Rat', Australian Neuroscience Society: Proceedings of the 25th Annual (2005) [E3]
Co-authors Philip Hansbro, Deborah Hodgson, Vanessa Murphy, Vicki Clifton
Show 7 more conferences
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Dr Olivia Wynne

Position

Research Assistant
School of Nursing and Midwifery
Faculty of Health and Medicine

Contact Details

Email olivia.wynne@newcastle.edu.au
Phone (02) 4921 5158
Fax (02) 4931 6301

Office

Room RW141
Building Richardson Wing
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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