2024 |
Tran DT, Robijn AL, Varney B, Zoega H, Brew BK, Chambers GM, et al., 'Data Resource Profile: The Early Life Course data platform for research on perinatal and early childhood exposures and outcomes in Australia.', Int J Epidemiol, 53 (2024) [C1]
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2024 |
Gong T, Brew BK, Lundholm C, Smew A, Harder A, Kuja-Halkola R, et al., 'Comorbidity Between Inflammatory Bowel Disease and Asthma and Allergic Diseases: A Genetically Informed Study', INFLAMMATORY BOWEL DISEASES, [C1]
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2024 |
Brew BK, Gong T, Ohlin E, Hedman AM, Larsson H, Curman P, et al., 'Maternal mental health disorders and offspring asthma and allergic diseases: The role of child mental health.', Pediatr Allergy Immunol, 35 e14085 (2024) [C1]
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2023 |
Mubanga M, Brew BHH, Karim H, Curman P, Hedman A, Lundholm C, Almqvist C, 'Maternal body mass index in pregnancy and offspring asthma and food allergy', ALLERGY,
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2023 |
Smew AI, Lundholm C, Gong T, Sävendahl L, Lichtenstein P, Brew BK, Almqvist C, 'Maternal depression or anxiety during pregnancy and offspring type 1 diabetes: A population-based family-design cohort study', BMJ Open Diabetes Research and Care, 11 (2023) [C1]
Introduction To investigate the association between maternal depression/anxiety during pregnancy and offspring type 1 diabetes, to assess the specific importance of exposure durin... [more]
Introduction To investigate the association between maternal depression/anxiety during pregnancy and offspring type 1 diabetes, to assess the specific importance of exposure during pregnancy by comparing across different exposure periods before and/or after pregnancy, and to explore potential unmeasured familial confounding. Research design and methods This was a population-based cohort including 1 807 809 offspring born in Sweden 2002-2019. From national registers, data were available on diagnosis or medication prescription for depression/anxiety in and around pregnancy, as well as incident cases of type 1 diabetes defined through diagnosis or insulin treatment. Associations were examined using flexible parametric and Cox regression models. Familial confounding was explored using paternal exposure as a negative control and by comparing offspring exposed to maternal depression/anxiety with their unexposed siblings. Results For exposure during pregnancy, maternal depression/anxiety was associated with an increased risk of offspring type 1 diabetes onset after, but not before, 8 years of age (adjusted HR (aHR) 1.21 (95% CI 1.03 to 1.42]). Exposure occurring only during pregnancy was similarly associated to type 1 diabetes (aHR 1.24 (0.96 to 1.60)), whereas exposure occurring only before pregnancy was not (aHR 0.91 (0.64 to 1.30)). Associations were close to the null for paternal depression/anxiety (aHR 0.95 (0.72 to 1.25)), and point estimates were above 1 in sibling comparisons, although with wide CIs (aHR 1.36 (0.82 to 2.26)). Conclusions Maternal depression/anxiety specifically during pregnancy seems to be associated with offspring type 1 diabetes. Paternal negative control and sibling comparisons indicate that the results cannot entirely be explained by familial confounding.
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2023 |
Mubanga M, Lundholm C, Rohlin ES, Rejnoe G, Brew BK, Almqvist C, 'Mode of delivery and offspring atopic dermatitis in a Swedish nationwide study', PEDIATRIC ALLERGY AND IMMUNOLOGY, 34 (2023) [C1]
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2023 |
Brew BK, Gibberd A, Marks GB, Murphy VE, Jorm L, Chambers GM, et al., 'Maternal asthma in Australian indigenous women and perinatal outcomes: A whole population-linked study.', Int J Gynaecol Obstet, 160 653-660 (2023) [C1]
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Nova |
2023 |
McDonald VM, Archbold G, Beyene T, Brew BK, Franklin P, Gibson PG, et al., 'Asthma and landscape fire smoke: A Thoracic Society of Australia and New Zealand position statement', Respirology, 28 1023-1035 (2023) [C1]
Landscape fires are increasing in frequency and severity globally. In Australia, extreme bushfires cause a large and increasing health and socioeconomic burden for communities and... [more]
Landscape fires are increasing in frequency and severity globally. In Australia, extreme bushfires cause a large and increasing health and socioeconomic burden for communities and governments. People with asthma are particularly vulnerable to the effects of landscape fire smoke (LFS) exposure. Here, we present a position statement from the Thoracic Society of Australia and New Zealand. Within this statement we provide a review of the impact of LFS on adults and children with asthma, highlighting the greater impact of LFS on vulnerable groups, particularly older people, pregnant women and Aboriginal and Torres Strait Islander peoples. We also highlight the development of asthma on the background of risk factors (smoking, occupation and atopy). Within this document we present advice for asthma management, smoke mitigation strategies and access to air quality information, that should be implemented during periods of LFS. We promote clinician awareness, and the implementation of public health messaging and preparation, especially for people with asthma.
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Nova |
2023 |
Hanly M, Brew BK, Austin A, Jorm L, 'Software Application Profile: The daggle app a tool to support learning and teaching the graphical rules of selecting adjustment variables using directed acyclic graphs', International Journal of Epidemiology, 52 1659-1664 (2023)
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2023 |
Brew BK, Donnolley N, Fitzgerald O, Molloy D, Chambers GM, 'Does a public online IVF prediction tool help set patient expectations? A mixed methods evaluation study.', Hum Reprod, 38 1761-1768 (2023) [C1]
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2022 |
Brew BK, Almqvist C, Lundholm C, Andreasson A, Lehto K, Talley NJ, Gong T, 'Comorbidity of atopic diseases and gastro-oesophageal reflux: evidence of a shared cause', Clinical and Experimental Allergy, 52 868-877 (2022) [C1]
Introduction: Gastro-oesophageal reflux disease (GERD) is the most common non-allergic comorbidity in adults with asthma; however, comorbidity with other atopic diseases such as e... [more]
Introduction: Gastro-oesophageal reflux disease (GERD) is the most common non-allergic comorbidity in adults with asthma; however, comorbidity with other atopic diseases such as eczema and hay fever is unclear. The objective was to assess the comorbidity of GERD with asthma and atopic diseases and to investigate possible mechanisms, including genetic and/or affective factors. Methods: A co-twin control study harnessing 46 583 adult twins. Questionnaires on health status were linked to national patient and prescribed drug register data. Analyses tested associations of comorbidity between multiple definitions of atopic diseases (self-report and register-based) with GERD. Comparisons were made between unpaired, monozygotic (MZ) and dizygotic (DZ) twins to assess genetic liability. Affective traits (depression, anxiety and neuroticism) were added to models as possible explanatory factors. Results: The risk of GERD in those with asthma was OR (odds ratio) 1.52 (95% CI 1.38, 1.68), hay fever OR 1.22 (95%CI 1.12, 1.34) and eczema OR 1.23 (95%CI 1.10, 1.38). Adjusting for affective traits completely attenuated the comorbidity associations for hay fever and eczema with GERD, and partly for asthma with GERD. Co-twin control associations attenuated suggesting a shared cause for both GERD and atopic diseases. For example, all twins adjOR 1.32 (95%CI 1.00, 1.74), 0.97 (95% CI 0.76¿1.23) and 1.11 (95%CI 0.85¿1.45) for self-report asthma, hay fever and eczema with GERD respectively. Conclusions: GERD is a common comorbidity in adults with asthma, hay fever and/or eczema. We found evidence for shared mechanisms suggesting common underlying causes that may involve affective traits requiring further investigation.
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Nova |
2022 |
Brew BK, Lundholm C, Osvald EC, Chambers G, Oberg S, Fang F, Almqvist C, 'Early-Life Adversity Due to Bereavement and Inflammatory Diseases in the Next Generation: A Population Study in Transgenerational Stress Exposure', AMERICAN JOURNAL OF EPIDEMIOLOGY, 191 38-48 (2022) [C1]
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2022 |
Osvald EC, Gong T, Lundholm C, Larsson H, Brew BK, Almqvist C, 'Parental socioeconomic status and asthma in children: Using a population-based cohort and family design', CLINICAL AND EXPERIMENTAL ALLERGY, 52 94-103 (2022) [C1]
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2022 |
Brew BK, 'Adverse perinatal outcomes in the Australian Indigenous population, the role of asthma', AUSTRALIAN & NEW ZEALAND JOURNAL OF OBSTETRICS & GYNAECOLOGY, 62 E3-E4 (2022)
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2022 |
Brew BK, Donnolley N, Henry A, Dahlen H, Jalaludin B, Chambers GM, 'Double jeopardy-pregnancy and birth during a catastrophic bushfire event followed by a pandemic lockdown, a natural experiment', Environmental Research, 214 (2022) [C1]
Background: From November 2019 to January 2020, eastern Australia experienced the worst bushfires in recorded history. Two months later, Sydney and surrounds were placed into lock... [more]
Background: From November 2019 to January 2020, eastern Australia experienced the worst bushfires in recorded history. Two months later, Sydney and surrounds were placed into lockdown for six weeks due to the COVID-19 pandemic, followed by ongoing restrictions. Many pregnant women at this time were exposed to both the bushfires and COVID-19 restrictions. Objective: To assess the impact of exposure to bushfires and pandemic restrictions on perinatal outcomes. Methods: The study included 60 054 pregnant women who gave birth between November 2017 and December 2020 in South Sydney. Exposure cohorts were based on conception and birthing dates: 1) bushfire late pregnancy, born before lockdown; 2) bushfires in early-mid pregnancy, born during lockdown or soon after; 3) conceived during bushfires, lockdown in second trimester; 4) conceived after bushfires, pregnancy during restrictions. Exposure cohorts were compared with pregnancies in the matching periods in the two years prior. Associations between exposure cohorts and gestational diabetes, preeclampsia, hypertension, stillbirth, mode of birth, birthweight, preterm birth and small for gestational age were assessed using generalised estimating equations, adjusting for covariates. Results: A decrease in low birth weight was observed for cohort 1 (aOR 0.81, 95%CI 0.69, 0.95). Conversely, cohort 2 showed an increase in low birth weight, and increases in prelabour rupture of membranes, and caesarean sections (aOR 1.18, 95%CI 1.03, 1.37; aOR 1.21, 95%CI 1.07, 1.37; aOR 1.10 (1.02, 1.18) respectively). Cohort 3 showed an increase in unplanned caesarean sections and high birth weight babies (aOR 1.15, 95%CI 1.04, 1.27 and aOR 1.16, 95%CI 1.02, 1.31 respectively), and a decrease in gestational diabetes mellitus was observed for both cohorts 3 and 4. Conclusion: Pregnancies exposed to both severe climate events and pandemic disruptions appear to have increased risk of adverse perinatal outcomes beyond only experiencing one event, but further research is needed.
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2022 |
Choi SKY, Gordon A, Hilder L, Henry A, Hyett JA, Brew BK, et al., 'Performance of Six Birth-Weight and Estimated-Fetal-Weight Standards for Predicting Adverse Perinatal Outcome: A 10-Year Nationwide Population-Based Study', OBSTETRICAL & GYNECOLOGICAL SURVEY, 77 69-70 (2022)
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2022 |
Lundholm C, Rejno G, Brew B, Smew A, Saltvedt S, Almqvist C, 'Associations Between Maternal Distress, Cortisol Levels, and Perinatal Outcomes', PSYCHOSOMATIC MEDICINE, 84 288-296 (2022) [C1]
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2022 |
Byberg KK, Lundholm C, Brew BK, Rejnö G, Almqvist C, 'Pre-eclampsia and risk of early-childhood asthma: A register study with sibling comparison and an exploration of intermediate variables', International Journal of Epidemiology, 51 749-758 (2022) [C1]
Background: We aimed to study whether pre-eclampsia is associated with childhood asthma, allergic and non-Allergic asthma, accounting for family factors and intermediate variables... [more]
Background: We aimed to study whether pre-eclampsia is associated with childhood asthma, allergic and non-Allergic asthma, accounting for family factors and intermediate variables. Methods: The study population comprised 779 711 children born in 2005-2012, identified from Swedish national health registers (n = 14 823/7410 exposed to mild/moderate and severe pre-eclampsia, respectively). We used Cox regression to estimate the associations of mild/moderate and severe pre-eclampsia with incident asthma, before and after age 2 years. Cox regressions were controlled for familial factors using sibling comparisons, then stratified on high and low risk for intermediate variables: caesarean section, prematurity and small for gestational age. We used logistic regression for allergic and non-Allergic prevalent asthma at 6 years as a measure of more established asthma. Results: The incidence of asthma in children was 7.7% (n = 60 239). The associations varied from adjusted hazard ratio (adjHR) 1.11, 95% confidence interval (CI): 1.00, 1.24 for mild/moderate pre-eclampsia and asthma at >2 years age, to adjHR 1.78, 95% CI: 1.64, 1.95 for severe pre-eclampsia and asthma at <2 years age. Sibling comparisons attenuated most estimates except for the association between severe pre-eclampsia and asthma at <2 years age (adjHR 1.45, 95% CI: 1.10, 1.90), which also remained when stratifying for the risk of intermediates. Mild/moderate and severe pre-eclampsia were associated with prevalent non-Allergic (but not allergic) asthma at 6 years, with adjusted odds ratio (adjOR) 1.17, 95% CI: 1.00, 1.36 and adjOR 1.51, 95% CI: 1.23, 1.84, respectively. Conclusions: We found evidence that severe, but not mild/moderate, pre-eclampsia is associated with asthma regardless of familial factors and confounders.
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2022 |
Brew BK, Osvald EC, Gong T, Hedman AM, Holmberg K, Larsson H, et al., 'Paediatric asthma and non-allergic comorbidities: A review of current risk and proposed mechanisms', CLINICAL AND EXPERIMENTAL ALLERGY, 52 1035-1047 (2022) [C1]
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2022 |
Fitzpatrick SJ, Brew BK, Handley T, Perkins D, 'Men, suicide, and family and interpersonal violence: A mixed methods exploratory study', SOCIOLOGY OF HEALTH & ILLNESS, 44 991-1008 (2022) [C1]
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Nova |
2022 |
Rhedin S, Lundholm C, Horne A, Smew AI, Osvald EC, Haddadi A, et al., 'Risk factors for multisystem inflammatory syndrome in children - A population-based cohort study of over 2 million children.', Lancet Reg Health Eur, 19 100443 (2022) [C1]
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2021 |
Fitzpatrick SJ, Handley T, Powell N, Read D, Inder KJ, Perkins D, Brew BK, 'Suicide in rural Australia: A retrospective study of mental health problems, health-seeking and service utilisation.', PLoS One, 16 (2021) [C1]
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Nova |
2021 |
Murphy VE, Karmaus W, Mattes J, Brew BK, Collison A, Holliday E, et al., 'Exposure to Stress and Air Pollution from Bushfires during Pregnancy: Could Epigenetic Changes Explain Effects on the Offspring?', INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH, 18 (2021) [C1]
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Nova |
2021 |
Slob EMA, Brew BK, Vijverberg SJH, Dijs T, van Beijsterveldt CEM, Koppelman GH, et al., 'Early-life antibiotic use and risk of attention-deficit hyperactivity disorder and autism spectrum disorder: results of a discordant twin study', INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 50 475-484 (2021) [C1]
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2021 |
Choi SKY, Gordon A, Hilder L, Henry A, Hyett JA, Brew BK, et al., 'Performance of six birth-weight and estimated-fetal-weight standards for predicting adverse perinatal outcome: a 10-year nationwide population-based study', ULTRASOUND IN OBSTETRICS & GYNECOLOGY, 58 264-277 (2021) [C1]
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2021 |
Stock SJ, Zoega H, Brockway M, Mulholland RH, Miller JE, Been JV, et al., 'The international Perinatal Outcomes in the Pandemic (iPOP) study: Protocol', Wellcome Open Research, 6 (2021)
Preterm birth is the leading cause of infant death worldwide, but the causes of preterm birth are largely unknown. During the early COVID-19 lockdowns, dramatic reductions in pret... [more]
Preterm birth is the leading cause of infant death worldwide, but the causes of preterm birth are largely unknown. During the early COVID-19 lockdowns, dramatic reductions in preterm birth were reported; however, these trends may be offset by increases in stillbirth rates. It is important to study these trends globally as the pandemic continues, and to understand the underlying cause(s). Lockdowns have dramatically impacted maternal workload, access to healthcare, hygiene practices, and air pollution - all of which could impact perinatal outcomes and might affect pregnant women differently in different regions of the world. In the international Perinatal Outcomes in the Pandemic (iPOP) Study, we will seize the unique opportunity offered by the COVID-19 pandemic to answer urgent questions about perinatal health. In the first two study phases, we will use population-based aggregate data and standardized outcome definitions to: 1) Determine rates of preterm birth, low birth weight, and stillbirth and describe changes during lockdowns; and assess if these changes are consistent globally, or differ by region and income setting, 2) Determine if the magnitude of changes in adverse perinatal outcomes during lockdown are modified by regional differences in COVID-19 infection rates, lockdown stringency, adherence to lockdown measures, air quality, or other social and economic markers, obtained from publicly available datasets. We will undertake an interrupted time series analysis covering births from January 2015 through July 2020. The iPOP Study will involve at least 121 researchers in 37 countries, including obstetricians, neonatologists, epidemiologists, public health researchers, environmental scientists, and policymakers. We will leverage the most disruptive and widespread 'natural experiment' of our lifetime to make rapid discoveries about preterm birth. Whether the COVID-19 pandemic is worsening or unexpectedly improving perinatal outcomes, our research will provide critical new information to shape prenatal care strategies throughout (and well beyond) the pandemic.
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2021 |
Brew B, Gibberd A, Marks GB, Strobel N, Allen CW, Jorm L, et al., 'Identifying preventable risk factors for hospitalised asthma in young Aboriginal children: A whole-population cohort study', Thorax, 76 539-546 (2021) [C1]
Background Australia has one of the highest rates of asthma worldwide. Indigenous children have a particularly high burden of risk determinants for asthma, yet little is known abo... [more]
Background Australia has one of the highest rates of asthma worldwide. Indigenous children have a particularly high burden of risk determinants for asthma, yet little is known about the asthma risk profile in this population. Aim To identify and quantify potentially preventable risk factors for hospitalised asthma in Australian Aboriginal children (1-4 years of age). Methods Birth, hospital and emergency data for all Aboriginal children born 2003-2012 in Western Australia were linked (n=32 333). Asthma was identified from hospitalisation codes. ORs and population attributable fractions were calculated for maternal age at birth, remoteness, area-level disadvantage, prematurity, low birth weight, maternal smoking in pregnancy, mode of delivery, maternal trauma and hospitalisations for acute respiratory tract infection (ARTI) in the first year of life. Results There were 705 (2.7%) children hospitalised at least once for asthma. Risk factors associated with asthma included: being hospitalised for an ARTI (OR 4.06, 95% CI 3.44 to 4.78), area-level disadvantage (OR 1.58, 95% CI 1.28 to 1.94), being born at <33 weeks' gestation (OR 3.30, 95% CI 2.52 to 4.32) or birth weight <1500 g (OR 2.35, 95% CI 1.39 to 3.99). The proportion of asthma attributable to an ARTI was 31%, area-level disadvantage 18%, maternal smoking 5%, and low gestational age and birth weight were 3%-7%. We did not observe a higher risk of asthma in those children who were from remote areas. Conclusion Improving care for pregnant Aboriginal women as well as for Aboriginal infants with ARTI may help reduce the burden of asthma in the Indigenous population.
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2021 |
Fitzpatrick SJ, Read D, Brew BK, Perkins D, 'A sociological autopsy lens on older adult suicide in rural Australia: Addressing health, psychosocial factors and care practices at the intersection of policies and institutions.', Social Science and Medicine, 284 (2021) [C1]
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Nova |
2020 |
Osvald EC, Bower H, Lundholm C, Larsson H, Brew BK, Almqvist C, 'Asthma and all-cause mortality in children and young adults: a population-based study', THORAX, 75 1040-1046 (2020) [C1]
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2020 |
Brew BK, Gong T, 'Modelling paternal exposure as a negative control', INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 49 1053-1054 (2020)
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2020 |
Slob EMA, Brew BK, Vijverberg SJH, Kats CJAR, Longo C, Pijnenburg MW, et al., 'Early-life antibiotic use and risk of asthma and eczema: results of a discordant twin study', EUROPEAN RESPIRATORY JOURNAL, 55 (2020) [C1]
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2020 |
Lundholm C, Brew BK, D'Onofrio BM, Osvald EC, Larsson H, Almqvist C, 'Asthma and subsequent school performance at age 15-16 years: A Swedish population-based sibling control study', SCIENTIFIC REPORTS, 10 (2020) [C1]
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2020 |
Robijn AL, Brew BK, Jensen ME, Rejnö G, Lundholm C, Murphy VE, Almqvist C, 'Effect of maternal asthma exacerbations on perinatal outcomes: a population-based study.', ERJ open research, 6 1-10 (2020) [C1]
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Nova |
2019 |
Ferreira MAR, Mathur R, Vonk JM, Szwajda A, Brumpton B, Granell R, et al., 'Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct', AMERICAN JOURNAL OF HUMAN GENETICS, 104 665-684 (2019) [C1]
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2019 |
Shaheen SO, Lundholm C, Brew BK, Almqvist C, 'Prescribed analgesics in pregnancy and risk of childhood asthma', EUROPEAN RESPIRATORY JOURNAL, 53 (2019) [C1]
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2019 |
Lehto K, Pedersen NL, Almqvist C, Lu Y, Brew BK, 'Asthma and affective traits in adults: a genetically informative study', EUROPEAN RESPIRATORY JOURNAL, 53 (2019)
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2019 |
Brew BK, Soderberg J, Lundholm C, Afshar S, Holmberg K, Almqvist C, 'Academic achievement of adolescents with asthma or atopic disease', CLINICAL AND EXPERIMENTAL ALLERGY, 49 892-899 (2019) [C1]
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2019 |
Floyd T, Martensson S, Bailey J, Kay D, McGarity B, Brew BK, 'The MOWER (middle of the week everyone gets a re-chart) pilot study: reducing in-hospital charting error with a multi-intervention', BMC HEALTH SERVICES RESEARCH, 19 (2019) [C1]
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2019 |
Brew BK, Chiesa F, Lundholm C, Ortqvist A, Almqvist C, 'A modern approach to identifying and characterizing child asthma and wheeze phenotypes based on clinical data', PLOS ONE, 14 (2019) [C1]
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2019 |
Rejno G, Lundholm C, Oberg S, Lichtenstein P, Larsson H, D'Onofrio B, et al., 'Maternal anxiety, depression and asthma and adverse pregnancy outcomes - a population based study', SCIENTIFIC REPORTS, 9 (2019) [C1]
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2019 |
Fitzpatrick SJ, Brew BK, Read DMY, Inder KJ, Hayes A, Perkins D, 'Rethinking Suicide in Rural Australia: A Study Protocol for Examining and Applying Knowledge of the Social Determinants to Improve Prevention in Non-Indigenous Populations', International Journal of Environmental Research and Public Health, 16 2944-2944 (2019)
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2018 |
Brew BK, Almqvist C, 'Acid Suppressant Use in Pregnancy and Asthma in Offspring: Should We Be Worried?', PEDIATRICS, 141 (2018)
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2018 |
Brew BK, Lundholm C, Viktorin A, Lichtenstein P, Larsson H, Almqvist C, 'Longitudinal depression or anxiety in mothers and offspring asthma: a Swedish population-based study', INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 47 166-174 (2018) [C1]
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2018 |
Garden FL, Toelle BG, Mihrshahi S, Webb KL, Almqvist C, Tovey ER, et al., 'Cohort profile: The Childhood Asthma Prevention Study (CAPS)', INTERNATIONAL JOURNAL OF EPIDEMIOLOGY, 47 1736-+ (2018)
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2018 |
Flanigan C, Sheikh A, DunnGalvin A, Brew BK, Almqvist C, Nwaru BI, 'Prenatal maternal psychosocial stress and offspring's asthma and allergic disease: A systematic review and meta-analysis', CLINICAL AND EXPERIMENTAL ALLERGY, 48 403-414 (2018) [C1]
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2018 |
Brew BK, Lundholm C, Gong T, Larsson H, Almqvist C, 'The familial aggregation of atopic diseases and depression or anxiety in children', CLINICAL AND EXPERIMENTAL ALLERGY, 48 703-711 (2018) [C1]
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2018 |
Hedman AM, Gong T, Lundholm C, Dahlen E, Ullemar V, Brew BK, Almqvist C, 'Agreement between asthma questionnaire and health care register data', PHARMACOEPIDEMIOLOGY AND DRUG SAFETY, 27 1139-1146 (2018) [C1]
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2017 |
Bailey J, Dutton T, Payne K, Wilson R, Brew BK, 'Farm Safety Practices and Farm Size in New South Wales', JOURNAL OF AGROMEDICINE, 22 229-234 (2017) [C1]
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2017 |
Medsker BH, Brew BK, Forno E, Olsson H, Lundholm C, Han Y-Y, et al., 'Maternal depressive symptoms, maternal asthma, and asthma in school-aged children', ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 118 55-U146 (2017) [C1]
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2017 |
Gong T, Brew B, Sjolander A, Almqvist C, 'Towards non-conventional methods of designing register-based epidemiological studies: An application to pediatric research', SCANDINAVIAN JOURNAL OF PUBLIC HEALTH, 45 30-35 (2017) [C1]
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2017 |
Brew BK, Gong T, Williams DM, Larsson H, Almqvist C, 'Using fathers as a negative control exposure to test the Developmental Origins of Health and Disease Hypothesis: A case study on maternal distress and offspring asthma using Swedish register data', SCANDINAVIAN JOURNAL OF PUBLIC HEALTH, 45 36-40 (2017)
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2016 |
Brew B, Inder K, Allen J, Thomas M, Kelly B, 'The health and wellbeing of Australian farmers: a longitudinal cohort study', BMC PUBLIC HEALTH, 16 (2016) [C1]
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Nova |
2015 |
Brew BK, Toelle BG, Webb KL, Almqvist C, Marksfor GB, 'Omega-3 supplementation during the first 5 years of life and later academic performance: a randomised controlled trial', EUROPEAN JOURNAL OF CLINICAL NUTRITION, 69 419-424 (2015)
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2015 |
Tall JA, Brew BK, Saurman E, Jones TC, 'Implementing an anti-smoking program in rural-remote communities: challenges and strategies', RURAL AND REMOTE HEALTH, 15 (2015)
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2015 |
Inder KJ, Hussain R, Allen J, Brew B, Lewin TJ, Attia J, Kelly BJ, 'Factors associated with personal hopefulness in older rural and urban residents of New South Wales', Advances in Mental Health, 13 43-57 (2015) [C1]
Background: As research focuses on the concept of resilience, evidence suggests that greater levels of personal hope may have a mitigating effect on the mental health impact of ad... [more]
Background: As research focuses on the concept of resilience, evidence suggests that greater levels of personal hope may have a mitigating effect on the mental health impact of adversity. In view of the adversity affecting rural communities, a better understanding of factors influencing personal hope may help identify foci for mental health promotion and mental illness prevention research and interventions. Aim: To explore the relationship between demographic, socioeconomic and mental health factors and personal hopefulness, including the influence of locality and remoteness. Method: Using data from two community-based longitudinal cohorts from New SouthWales ¿ one urban and one rural ¿ we analysed cross-sectional relationships between a range of factors and personal hopefulness using logistic regression techniques, as part of a common follow-up. Personal hopefulness was measured using a 12-item scale and scores were categorised as low (<2.5), medium (2.5¿3.4) and high (=3.5). Results: Of 2774 participants (53% female, mean age 69.1 years [SD 7.3, range 58¿91 years], 36% living outside metropolitan areas) 32% had low, 51% had medium and 17% had high personal hopefulness scores. Several factors displayed univariate associations with personal hopefulness. In the multivariate model, five factors were independently associated with lower personal hopefulness: being older, having lower perceived prosperity, less frequent socialisation, experiencing high psychological distress or psychological impairment. Hopefulness was not associated with geographical location. Conclusion: The impact of current psychological distress and aspects of adversity on personal hopefulness over time should be further investigated in longitudinal research. Personal hopefulness did not differ across geographical location.
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Nova |
2014 |
Brew BK, Marks GB, Almqvist C, Cistulli PA, Webb K, Marshall NS, 'Breastfeeding and Snoring: A Birth Cohort Study', PLOS ONE, 9 (2014)
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Nova |
2012 |
Brew BK, Kull I, Garden F, Almqvist C, Bergstrom A, Lind T, et al., 'Breastfeeding, asthma, and allergy: a tale of two cities', PEDIATRIC ALLERGY AND IMMUNOLOGY, 23 75-82 (2012)
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Nova |
2012 |
Brew BK, Marks GB, 'Perinatal factors and respiratory health in children', CLINICAL AND EXPERIMENTAL ALLERGY, 42 1621-1629 (2012)
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Nova |
2011 |
Brew BK, Allen CW, Toelle BG, Marks GB, 'Systematic review and meta-analysis investigating breast feeding and childhood wheezing illness', PAEDIATRIC AND PERINATAL EPIDEMIOLOGY, 25 507-518 (2011)
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Nova |
1998 |
Johnson DW, Saunders HJ, Brew BK, Poronnik P, Cook DI, Field MJ, Pollock CA, 'TGF-beta(1) dissociates human proximal tubule cell growth and Na+-H+ exchange activity', KIDNEY INTERNATIONAL, 53 1601-1607 (1998)
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Nova |
1997 |
Johnson DW, Brew BK, Poronnik P, Cook DI, Gyory AZ, Field MJ, Pollock CA, 'Transport characteristics of human proximal tubule cells in primary culture', NEPHROLOGY, 3 183-194 (1997)
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1997 |
Johnson DW, Brew BK, Poronnik P, Cook DI, Field MJ, Gyory AZ, Pollock CA, 'Insulin-like growth factor I stimulates apical sodium/hydrogen exchange in human proximal tubule cells', AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 272 F484-F490 (1997)
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Nova |
1997 |
Johnson DW, Brew BK, Poronnik P, Cook DI, Field MJ, Györy AZ, Pollock CA, 'Insulin-like growth factor i stimulates apical sodium/hydrogen exchange in human proximal tubule cells', American Journal of Physiology, 272 (1997)
To determine whether insulin-like growth factor I (IGF-I) stimulated apical sodium/hydrogen exchange (NHE), confluent primary human proximal tubule cells (PTC) were incubated for ... [more]
To determine whether insulin-like growth factor I (IGF-I) stimulated apical sodium/hydrogen exchange (NHE), confluent primary human proximal tubule cells (PTC) were incubated for 48 h in serum-free media in the presence or absence of 100 ng/ml IGF-I. Cells incubated in IGF-I demonstrated significant increases in thymidine incorporation (181.2 ± 30.3% of control values; n = 12, P = 0.01) and in resting intracellular pH (pHi) (7.52 ± 0.08 vs. 7.30 ± 0.06; n = 20, P < 0.05), as determined by 2',7'-bis(carboxyethyl)-5(6)-carboxyfluorescein quantitative microspectrofluorometry. Following intracellular acid loading, ethylisopropylamiloride (EIPA)-inhibitable H+ efflux and 22Na+ influx after 1 min were both significantly enhanced in IGF-I-treated cells compared with controls (8.78 ± 1.69 vs. 3.03 ± 0.72 mM/min and 3.47 ± 0.49 vs. 1.55 ± 0.35 nmol · mg protein-1 · min-1, respectively). 22Na+ uptake studies in PTC grown on permeable supports demonstrated preferential stimulation of apical vs. basolateral NHE. The 50% inhibitory concentrations (IC50) in IGF-I-treated and control cells for EIPA (0.5 and 1.1 pM, respectively) and for HOE-694 (4.0 and 10.0 µM, respectively) were also consistent with predominant activation of apical, rather than basolateral, NHE activity. Kinetic analysis revealed an increase in maximal transport velocity (Vmax, 15.50 ± 1.50 vs. 7.26 ± 3.07 mM/min; n = 10, P < 0.05), without a significant change in antiporter affinity for extracellular Na+. Incubation of PTC with 100 ng/ml IGF-I produced an acute, reversible, and EIPA-inhibitable pH; increase of 0.05 ± 0.01 pH units (n = 5, P < 0.05). The results suggest that IGF-I may contribute to the metachronous stimulation of apical NHE and PTC growth observed in many physiological and pathological conditions involving the human kidney. Copyright © 1997 the American Physiological Society.
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1997 |
Johnson DW, Brew BK, Poronnik P, Cook DI, Field MJ, Györy AZ, Pollock CA, 'Insulin-like growth factor I stimulates apical sodium/hydrogen exchange in human proximal tubule cells', American Journal of Physiology - Renal Physiology, 272 (1997)
To determine whether insulin-like growth factor I (IGF-I) stimulated epical sodium/hydrogen exchange (NHE), confluent primary human proximal tubule cells (PTC) were incubated for ... [more]
To determine whether insulin-like growth factor I (IGF-I) stimulated epical sodium/hydrogen exchange (NHE), confluent primary human proximal tubule cells (PTC) were incubated for 48 h in serum-free media in the presence or absence of 100 ng/ml IGF-I. Cells incubated in IGF-I demonstrated significant increases in thymidine incorporation (181.2 ± 30.3% of control values; n = 12, P = 0.01) and in resting intracellular pH (pH(i)) (7.52 ± 0.08 vs. 7.30 ± 0.06; n = 20, P < 0.05), as determined by 2',7'- bis(carboxyethyl)-5(6)-carboxyfluorescein quantitative microspectrofluorometry. Following intracellular acid loading, ethylisopropylamiloride (EIPA)-inhibitable H+ efflux and 22Na+ influx after 1 min were both significantly enhanced in IGF-I-treated cells compared with controls (8.78 ± 1.69 vs. 3.03 ± 0.72 mM/min and 3.47 ± 0.49 vs. 1.55 ± 0.35 nmol·mg protein-1-·min-1, respectively). 22Na+ uptake studies in PTC grown on permeable supports demonstrated preferential stimulation of epical vs. basolateral NHE. The 50% inhibitory concentrations (IC50) in IGF-I-treated and control cells for EIPA (0.5 and 1.1 µM, respectively) and for HOE-694 (4.0 and 10.0 µM, respectively) were also consistent with predominant activation of epical, rather than basolateral, NHE activity. Kinetic analysis revealed an increase in maximal transport velocity (V(max), 15.50 ± 1.50 vs. 7.26 ± 3.07 mM/min; n = 10, P < 0.05), without a significant change in antiporter affinity for extracellular Na+. Incubation of PTC with 100 ng/ml IGF-I produced an acute, reversible, and EIPA-inhibitable PH(i) increase of 0.05 ± 0.01 pH units (n = 5, P < 0.05). The results suggest that IGF-I may contribute to the metachronous stimulation of epical NHE and PTC growth observed in many physiological and pathological conditions involving the human kidney.
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1997 |
Johnson DW, Brew BK, 'Insulin-like growth factor i stimulates apical sodium/hydrogen exchange in human proximal tubule cells', American Journal of Physiology - Heart and Circulatory Physiology, 41 (1997)
To determine whether insulin-like erowth factor I (IGF-I) stimulated apical sodium/hydrogen exchange (NHE), confluent primary human proximal tubule cells (PTC) were incubated for ... [more]
To determine whether insulin-like erowth factor I (IGF-I) stimulated apical sodium/hydrogen exchange (NHE), confluent primary human proximal tubule cells (PTC) were incubated for 48 h in serum-free media in the presence or absence of 100 ng/ml IGF-I. Cells incubated in IGF-I demonstrated significant increases in thymidine incorporation (181.2 ±30.3% of control values; n = 12, P = 0.01) and in resting intracellular pH (pH;) (7.52 ±0.08 vs. 7.30 ±0.06; n = 20, P < 0.05), as determined by 2', 7'-bis(carboxyethyl)-5(6)carboxyfluorescein quantitative microspectrofluorometry. Following intracellular acid loading, ethylisopropylamiloride (EIPA)-inhibitable H+ efflux and 22Na+ influx after l min were both significantly enhanced in IGF-I-treated cells compared with controls (8.78 ±1.69 vs. 3.03 ±0.72 mM/min and 3.47 ±0.49 vs. 1.55 ±0.35 nmol-mg protein"1-min-1, respectively). 22Na+ uptake studies in PTC grown on permeable supports demonstrated preferential stimulation of apical vs. basolateral NHE. The 50% inhibitory concentrations (IC50) in IGF-I-treated and control cells for EIPA(0.5 and 1.1 pM, respectively) and for HOE-694 (4.0 and 10.0 uM, respectively) were also consistent with predominant activation of apical, rather than basolateral, NHE activity. Kinetic analysis revealed an increase in maximal transport velocity (Fmax, 15.50 ±1.50 vs. 7.26 ±3.07 mM/min; n = 10, P < 0.05), without a significant change in antiporter affinity for extracellular Na+. Incubation of PTC with 100 ng/ml IGF-I produced an acute, reversible, and EIPA-inhibitable pH; increase of 0.05 ±0.01 pH units (n = 5, P < 0.05). The results suggest that IGF-I may contribute to the metachronous stimulation of apical NHE arid PTC growth observed in many physiological and pathological conditions involving the human kidney. Copyright ©1997 the American Physiological Society.
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1997 |
Johnson DW, Saunders HJ, Brew BK, Ganesan A, Baxter RC, Poronnik P, et al., 'Human renal fibroblasts modulate proximal tubule cell growth and transport via the TGF-I axis', KIDNEY INTERNATIONAL, 52 1486-1496 (1997)
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