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Professor Zsolt Balogh

Professor of Surgery

School of Medicine and Public Health

Career Summary

Biography

Professor Balogh is the Discipline Head of Traumatology and leads the Traumatology Research Group at the University of Newcastle. He is also the Director of Trauma Surgery at the John Hunter Hospital and Hunter New England Local Health District. Apart from a teacher and researcher, he is an active trauma and orthopaedic surgeon with a major interest in complex polytrauma patients and pelvic and acetabulum fracture patients. As the Discipline Head of Traumatology, Professor Balogh is responsible for the Trauma curriculum at the University of Newcastle, which has formal components in years 1,3,4 and 5 in the Medical School. His research covers many areas of trauma care such as orthopaedic trauma, torso trauma and postinjury critical care. He collaborates with academic trauma centres and Universities in Europe, United States and Australia. Professor Balogh supervises the Traumatology PhD program at The University of Newcastle and clinical and research fellowship programs at the John Hunter Hospital.

Research Expertise
Objective Research Measures (May 2014): Cumulative impact factor (based on the year of publication): 411.949 H-score : 24 Citations: 2883 Clinical and laboratory research on major trauma, traumatic shock, postinjury inflammation and its complications. Clinical and laboratory research on major orthopaedic trauma. Clinical research on pelvic fractures. Clinical research on geriatric/fragility fractures. Trauma epidemiology, outcome and trauma score research.

Teaching Expertise
Professor Balogh provides undergraduate and postgraduate education in wide aspects of trauma care, orthopaedics and critical care at local, national and international levels. He has mentored many students, residents, fellows and PhD students who have won awards and scholarships in these areas: 2014 - 83rd RACS Anual Scientific Congress - Best scientified paper: Trauma Research Papers Competition (Dr Daniel McIlroy, PhD student) - Neutrophil extracellular traps formed following trauma and subsequent surgery contain mitochondrial DNA 2011- 1st Prize, Hunter Orthopedic Society Meeting, Best Paper Competition (by Dr Osamu Yoshino, PhD student) – Polytrauma model with femur fracture. 2011 – American Association for the Surgery of Trauma – Medical Student travel scholarship to attend the AAST annual meeting in Chicago, IL, USA (by Benjamin Hardy, medical student, BMed student researcher). 2011 – International Association of Trauma Surgery and Intensive Care (IATSIC) – best paper presentation, Yokohama, Japan (“Blunt polytrauma model with femur fracture” by Dr Osamu Yoshino, resident, PhD student). 2011 – International Society of Surgery – Australasian Chapter – Travelling fellowship to the International Surgical Week in Yokohama, Japan (by Dr Osamu Yoshino, resident, PhD student). 2011 – European Society of Trauma and Emergency Surgery – Young Researcher Travel Award (by Dr Nerida Butcher, senior resident) for the European Society of Trauma and Emergency Surgery conference, Milano, Italy. – Definition of Polytrauma, International consensus initiative. 2010 – 1st Prize, Australian Orthopaedic Registrar Association - Registrar Paper Competition (by Dr Nicole Williams, orthopaedic registrar). Adelaide, SA. – Outcomes of low energy hip fractures in a major trauma centre. 2010 – 1st Prize, Australian Orthopaedic Association (NSW Branch) Registrar Competition (by Dr Nicole Williams, orthopaedic registrar). Sydney, NSW. – Outcomes of low energy hip fractures in a major trauma centre. 2009 – 1st Prize, Royal Australasian College of Surgeons, Annual Trauma Registrar/Fellow Competition (by Dr Andrew Martin, trauma fellow). Adelaide, SA. – Redefinition of haemorrhagic shock for the Australian trauma registries. Delegated to Las Vegas, Nevada in 2010 for the International Competition, to represent the Asia Pacific Region. 2009- 1st Prize, Hunter Orthopedic Society Meeting, Best Paper Competition. (by Dr Laszlo Toth, Trauma Fellow) – Prediction of Arterial bleeding in haemodynamically unstable pelvic fractures. 2008 – 1st Prize, Royal Australasian College of Surgeons, Annual Scientific Congress, Best Trauma Free Paper. (by Tim Arnold, BMed Student), Hong Kong, China – The correlation of arterial and venous base deficit during trauma resuscitation. 2008 – 2nd Prize, Royal Australasian College of Surgeons, Annual Trauma Registrar/Fellow Competition (by Dr Laszlo Toth, Trauma Fellow). Melbourne, Victoria. – The safety and efficacy of pelvic binding. 2008- 1st Prize, Hunter Orthopedic Society Meeting, Best Paper Competition (by Dr Ben Nicholas, Surgical Intern) – Early total care versus damage control orthopaedics: the Australian perspective. 2007 – 1st Prize, Royal Australasian College of Surgeons, Annual Trauma Registrar/Fellow Competition (by Dr David Dewar, Orthopedic Registrar/PhD Student). Melbourne, Victoria. – The epidemiology of postinjury multiple organ failure. Delegated to Washington DC in 2008 for the International Competition, represented the Asia Pacific Region. 2007- 1st Prize, Hunter Orthopedic Society Meeting, Best Paper Competition (by Dr David Dewar, Orthopedic Registrar/PhD Student) – Postinjury MOF for the orthopedic surgeon.

Administrative Expertise
Professor Balogh is the Director of Trauma Services for the John Hunter Hospital and Hunter New England Trauma System. Discipline Head of Traumatology, University of Newcastle Year 5 Orthopaedics/Trauma Co-ordinator.

Collaborations
The Traumatology Research Group has extensive collaborations locally (John Hunter Hospital, University of Newcastle), NSW, Interstate and at International levels. Current and past key collaborating Institutions: Hunter Medical Research Institute University of NSW Queensland University of Technology National Trauma Research Institute / Monash University NSW Institute of Trauma and Injury Management University of Colorado, Denver, USA University of Texas-Houston Medical School, USA Cornell University, The Methodist Hospital, Houston, USA University of Leeds, UK University of Aachen, Germany AO Research Institute, Switzerland.


Keywords

  • Abdominal Compartment Syndrome
  • Behavioural research in trauma patients: alcohol and smoking
  • Fragility / Geriatric Fractures
  • Major Pelvic Fractures
  • Orthopaedic Trauma - timing of fracture fixation, multiple long bone fractures
  • Physiological response to trauma
  • Polytrauma
  • Postinjury Multiple Organ Failure
  • Postinjury immunology/inflammation
  • Trauma Scoring - Polytrauma Definition
  • • Orthopaedics
  • • Pelvic surgery
  • • Postinjury critical care
  • • Trauma care

Fields of Research

CodeDescriptionPercentage
110299Cardiorespiratory Medicine and Haematology not elsewhere classified15
110314Orthopaedics40
111799Public Health and Health Services not elsewhere classified45

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
1/04/2015 - Professor of SurgeryUniversity of Newcastle
School of Medicine and Public Health
Australia
26/07/2014 - 27/07/2014Casual LecturerUniversity of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

DatesTitleOrganisation / Department
1/01/2011 - Editorial Board - The Journal of TraumaThe Journal of Trauma
Australia
1/01/2010 - Asoociate Editor - Surgical Techniques Development Journal Surgical Techniques Development Journal
Australia
1/01/2010 - Fellow - Australian Orthopaedic AssociationAOA Australian Orthopaedic Association
1/01/2010 - Associate Editor-in-Chief - International Journal of Burns and TraumaInternational Journal of Burns and Trauma
Australia
1/01/2010 - Section Editor (Polytrauma) - European Journal of Trauma and Emergency SurgeryEuropean Journal of Trauma and Emergency Surgery
United States
1/05/2009 - Professor of TraumatologyUniversity of Newcastle
School of Medicine and Public Health
Australia
1/01/2009 - Specialty Editor (Trauma) - ANZ Journal of SurgeryANZ Journal of Surgery
Australia
1/01/2009 - Fellow - American College of SurgeonsAmerican College of Surgeons
United States
1/01/2009 - 31/12/2009Editorial Board - World Journal of SurgeryWorld Journal of Surgery
Australia
1/01/2009 - Editorial Board - Clinical Medicine Insights: Trauma and Intensive Medicine JournalClinical Medicine Insights: Trauma and Intensive Medicine Journal
Australia
1/01/2009 - Editorial Board - Journal of Trauma Management and OutcomesJournal of Trauma Management and Outcomes
Australia
1/01/2009 - Membership - Western Trauma Association (USA)Western Trauma Association (USA)
United States
1/01/2008 - 31/12/2008Editorial Board - Current Opinion in Critical Care JournalCurrent Opinion in Critical Care Journal
Australia
1/01/2008 - Editorial Board - World Journal of Emergency SurgeryWorld Journal of Emergency Surgery
Australia
1/01/2007 - Editorial Board - Turkish Journal of Trauma and Emergency SurgeryTurkish Journal of Trauma and Emergency Surgery
Australia
1/01/2006 - Fellow - Royal Australasian College of SurgeonsRoyal Australasian College of Surgeons
1/01/2005 - Director of Trauma ServicesHunter New England Health
John Hunter Hospital
Australia
1/01/2005 - Editorial Board - Injury JournalInjury Journal
Australia

Membership

DatesTitleOrganisation / Department
1/01/2010 - Membership - American Association for the Surgery of TraumaAmerican Association for the Surgery of Trauma
United States
1/01/2010 - Membership - American Academy of Orthopaedic SurgeonsAmerican Academy of Orthopaedic Surgeons
United States
1/01/2010 - Membership - Australasian Trauma SocietyAustralasian Trauma Society
Australia
1/01/2010 - Membership - Australian Medical AssociationAustralian Medical Association
Australia
1/01/2009 - Executive Member - Australian and New Zealand Association for the Surgery of Trauma Australian and New Zealand Association for the Surgery of Trauma
Australia
1/01/2009 - Membership - AO Foundation/AO Trauma (AO Trustee for Australia)AO Foundation/AO Trauma (AO Trustee for Australia)
Australia
1/01/2009 - Membership - Hunter Medical Research InstituteUniversity of Newcastle
Hunter Medical Research Institute
Australia
1/01/2009 - Membership - Hunter Surgical SocietyHunter Surgical Society
Australia
1/01/2009 - Membership - International Association of Trauma Surgery and Intensive CareInternational Association of Trauma Surgery and Intensive Care
Australia
1/01/2009 - Membership - International Society of SurgeryInternational Society of Surgery
Australia
1/01/2009 - Membership - Orthopaedic Trauma Association (USA)Orthopaedic Trauma Association
United States
1/01/2009 - Membership - RACS Section of Academic SurgeryRoyal Australasian College of Surgeons (RACS)
Australia
1/01/2009 - Secretary and Executive Member - World Society of Abdominal Compartment Syndrome World Society of Abdominal Compartment Syndrome
Australia
1/01/2008 - Membership - Hunter Orthopaedic SocietyHunter Orthopaedic Society
Australia
1/01/2008 - Membership - Hungarian Society of TraumatologyHungarian Society of Traumatology
Hungary
1/01/2008 - Membership - RACS Trauma Education and Curriculum Development Sub-CommitteeRoyal Australasian College of Surgeons (RACS)
Australia
1/01/2008 - Secretary and Executive Member - Australian Orthopaedic Trauma Society Australian Orthopaedic Trauma Society
Australia
1/01/2005 - Membership - RACS Definitive Surgical Trauma Management Course CommitteeRoyal Australasian College of Surgeons (RACS)
Australia
1/01/2005 - Membership - RACS Trauma CommitteeRoyal Australasian College of Surgeons (RACS)
Australia
1/01/2003 - Membership - European Association for Trauma and Emergency SurgeryEuropean Association for Trauma and Emergency Surgery
Austria

Professional appointment

DatesTitleOrganisation / Department
1/01/2005 - Orthopaedic Trauma Surgeon and, Trauma SurgeonHunter New England Area Health Service
John Hunter Hospital
Australia

Awards

Recognition

YearAward
2014Excellence in Reviewing
Injury - International Journal of the Care of the Injured
2014Official AOTrauma Fellowship Host Centre
John Hunter Hospital
2013Award for best paper 2010-2011 World Journal of Surgery
International Society of Surgery (ISS) Société Internationale de Chirurgie (SIC)
2013Best Surgeon Innovator
AO Foundation
2012Certificate of Outstanding Service
Royal Australasian College of Surgeons (RACS)
2011Honorary Professor
Peking University
2006Orthopedic consultant/educator of the year
Hunter New England Health

Research Award

YearAward
2014Orthopaedic Research Award
AOA Australian Orthopaedic Association
2014John Mitchell Crouch Fellowship
Royal Australasian College of Surgeons
2010Research Excellence Award
University of Newcastle
2008Staff Achievement Awards
Hunter New England Health
2005Travelling Fellowship
Royal Australasian College of Surgeons (RACS)

Invitations

Distinguished Visitor

YearTitle / Rationale
2011Abdominal compartment syndrome: From recognition to the solution
Organisation: Habilitation Lecture Series, University of Szeged Description: .
2011The organisation of polytrauma care: Initial management, priorities
Organisation: Habilitation Lecture Series, University of Szeged Description: .
2011Trauma nursing in Australia
Organisation: Annual Congress of the Dutch Trauma Society Description: .
2011Abdominal compartment syndrome: From recognition to solution
Organisation: Annual Congress of the Dutch Trauma Society Description: .
2011Damage control orthopaedics: pushing the envelope
Organisation: Annual Congress of the Dutch Trauma Society Description: .
2011How to develop a trauma research centre
Organisation: Annual Congress of the Dutch Trauma Society Description: .
2011The development of a trauma centre: The Newcastle Experience
Organisation: Journal Club of the Gold Coast Hospital Orthopaedic Surgeons Description: .
2011The management of haemodynamically unstable pelvic fractures
Organisation: Annual Trauma Congress of the Peking University Description: .
2009Recent advancements on the management of patients with haemodynamically unstable pelvic fractures
Organisation: National Institute of Traumatology, Peterfy Hospital and Trauma Center - Institutional Trauma Course Description: .
2009Penetrating trauma cases presentation
Organisation: Definitive Surgical Trauma Care Workshop on Trauma to Visceral Organs, European Society for Trauma and Emergency Surgery Description: .
2009Damage control, packing, abdominal compartment syndrome
Organisation: Definitive Surgical Trauma Care Workshop on Trauma to Visceral Organs, European Society for Trauma and Emergency Surgery Description: .
2009Blunt trauma case presentation
Organisation: Definitive Surgical Trauma Care Workshop on Trauma to Visceral Organs, European Society for Trauma and Emergency Surgery Description: .
2009Which diagnostic steps are necessary in visceral trauma?
Organisation: Definitive Surgical Trauma Care Workshop on Trauma to Visceral Organs, European Society for Trauma and Emergency Surgery Description: .

Keynote Speaker

YearTitle / Rationale
2011The American Trauma System
Organisation: Polytrauma Management Beyond ATLS Description: .
2011Haemorrhage control versus cranial decompression? Debate for haemorrhage control
Organisation: Polytrauma Management Beyond ATLS Description: .
2011Priorities in lifesaving surgical interventions: What comes first?
Organisation: Polytrauma Management Beyond ATLS Description: .
2010Epidemiology of traumatic deaths: Comprehensive population-based assessment
Organisation: 10th International Summit on Trauma, Shock, Infection and Sepsis (TSIS) Description: .
2010The definition of Polytrauma
Organisation: Aachen Polytrauma Summit Description: .
2009Immune modulation in trauma
Organisation: Pre-Congress Instructional Course on Surgical Infections, 10th European Congress of Trauma and Emergency Surgery Description: .
2009Trauma and infection
Organisation: Pre-Congress Instructional Course on Surgical Infections, 10th European Congress of Trauma and Emergency Surgery Description: .
2009Prediction of ACS
Organisation: 4th World Congress Abdominal Compartment Syndrome Description: .
2009When to open/close the abdomen: Interactive case presentations with Dr Ivatury
Organisation: 4th World Congress Abdominal Compartment Syndrome Description: .
2008Ankle fractures
Organisation: International Fall Trauma Symposium Description: .
2008Early management and decision making
Organisation: International Fall Trauma Symposium Description: .
2008Abdominal compartment syndrome: Diagnosis and treatment
Organisation: XXXVI Biennial World Congress of the International College of Surgeons Description: .
2007Abdominal compartment syndrome complicating infection
Organisation: 7th World Congress on Trauma, Shock, Inflammation and Sepsis Description: .
2007Post injury multiple organ failure: History, current trends and future directions
Organisation: Injury 2007 Description: .
2007Management of the complex pelvic fracture
Organisation: Injury 2007 Description: .

Speaker

YearTitle / Rationale
2012Damage control orthopaedics: Quo vadis
Organisation: 12th Co-operative Course Polytrauma Management - Beyond ATLAS Description: .
2012Current management of unstable pelvic fractures
Organisation: 4th Annual Southwest Trauma & Acute Care Symposium Description: .
2012A review of causes for mortality in hip fracture patients
Organisation: Whitlam Orthopaedic Research Centre Symposium Description: .
2012Cornerstones of "The Golden Standard" in Trauma management
Organisation: Partnerships to Better Patient Outcomes Description: .
2012The development of the trauma system in the Hunter and well beyond
Organisation: Critical Care Conference in the Vineyards Description: .
2012Haemodynamically unstable pelvic fractures
Organisation: Kyungpook National University Hospital Description: .
2011Consensus on Polytrauma - no physiological parameters needed for the definition
Organisation: European Society of Trauma and Emergency Surgery Description: .
2011Damage control surgery is an outdated, overused concept
Organisation: SWAN Trauma Conference Description: .
2011Damage control vs definitive care: where is the line?
Organisation: 5th World Congress Abdominal Compartment Syndrome Description: .
2011Postinjury abdominal compartment syndrome
Organisation: International Association of Trauma and Intensive Care Description: .
2010Ethics in acute care
Organisation: Medical Leadership Development Seminar, University of Newcastle Description: .
2006Invited Instructor/Speaker
Organisation: National Trauma Management Course, National Academy of Traumatology Description: .
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (9 outputs)

YearCitationAltmetricsLink
2013Balogh ZJ, Yoshino O, 'Abdominal compartment syndrome', Common Problems in Acute Care Surgery, Springer New York 445-450 (2013)

Abdominal compartment syndrome (ACS) is a life-threatening condition associated with organ dysfunction/failure due to increased intra-abdominal pressure (IAP). Based on consensus,... [more]

Abdominal compartment syndrome (ACS) is a life-threatening condition associated with organ dysfunction/failure due to increased intra-abdominal pressure (IAP). Based on consensus, ACS is defined as IAP > 20 mmHg and vital organ dysfunction related to it. Increased IAP without organ dysfunction is considered intra-abdominal hypertension (IAH) and graded (I: 12-15 mmHg, II: 16-20 mmHg, III: 21-25 mmHg, IV: >25 mmHg) [1, 2]. The physiological compromise from increased IAP was first described in the nineteenth century in the clinical setting, and then during the early twentieth century in the laboratory setting [3, 4]. The avoidance of increased IAP, and its resultant catastrophic respiratory and renal function consequences, was first advocated by pediatric surgeons using silos to close large omphaloceles [5]. The term ACS was coined by Fietsam et al. who described the syndrome as a complication of the management of ruptured abdominal aortic aneurisms [6]. Damage control surgery made it possible to salvage patients from previously irreversible traumatic shock and resuscitate them to reach the intensive care unit (ICU) in critical condition [7, 8]. Among these severe shock/trauma patients, ACS was a frequent cause of death, unplanned returns to the operating room, and prolonged ICU stays [9, 10]. Based on the trauma experience, acute care surgeons have applied the principles of prevention, recognition, and management to acute general surgical patients. In the same time, most surgical and nonsurgical specialties have reported on ACS from their experience.

DOI10.1007/978-1-4614-6123-4_36
CitationsScopus - 1
2012Balogh ZJ, Yoshino O, Sugrue M, 'Abdominal compartment syndrome', Penetrating Trauma: A Practical Guide on Operative Technique and Peri-operative Management, Springer-Verlag, Heidelberg 401-406 (2012) [B2]
2012Bendinelli C, Balogh ZJ, 'Laparoscopy in trauma patients', Advances in Laparoscopic Surgery, InTech, Rijeka, Croatia 43-52 (2012) [B2]
2011Sucher JF, Balogh ZJ, Moore FA, 'Abdominal compartment syndrome and management of the open abdomen', Current Surgical Therapy, Elsevier, Philadelphia, PA 1001-1007 (2011) [B2]
2007Balogh Z, McKinley BA, Moore FA, 'Multiple organ Failure', Perioperative fluid therapy, Informa Healthcare, New York, United States 525-536 (2007) [B2]
2006Balogh ZJ, Moore FA, Goettler CE, Rotondo MF, Schwab CW, Kaplan MJ, 'Surgical management of abdominal compartment syndrome', Abdominal Compartment Syndrome, Landes Bioscience, Georgetown, Texas 266-296 (2006) [B2]
2006Balogh ZJ, Moore FA, 'Postinjury secondary abdominal compartment syndrome', Abdominal Compartment Syndrome, Landes Bioscience, Georgetown, Texas 170-177 (2006) [B2]
2005Balogh ZJ, Moore FA, 'Abdominal compartment syndrome', Textbook of Critical Care, Elsevier, Philadelphia, PA 1469-1475 (2005) [B2]
2000Balogh ZJ, Wolfard A, Szalay L, Simonka JA, Boros M, 'The effects of low-molecular-weight heparin on leukocyte-endothelial cell interactions in hemorrhagic shock and reperfusion.', Trauma, Shock, Inflammation and Sepsis, pathophysiology immune consequences and therapy, Monduzzi Editore, Milan, Italy 315-319 (2000) [B1]
Show 6 more chapters

Journal article (170 outputs)

YearCitationAltmetricsLink
2015McIlroy DJ, Bigland M, White AE, Hardy BM, Lott N, Smith DW, Balogh ZJ, 'Cell necrosis-independent sustained mitochondrial and nuclear DNA release following trauma surgery.', J Trauma Acute Care Surg, 78 282-288 (2015)
DOI10.1097/TA.0000000000000519Author URL
CitationsWeb of Science - 1
Co-authorsDouglas Smith
2015Tarrant SM, Balogh ZJ, 'Low-energy falls.', ANZ J Surg, 85 202-203 (2015)
DOI10.1111/ans.13002Author URL
2015Gunning A, Voskens F, van Heijl M, Balogh Z, Maier R, Leenen L, 'Global Patterns and Outcomes of Patients With Traumatic Brain Injury', JOURNAL OF HEAD TRAUMA REHABILITATION, 30 E87-E87 (2015)
Author URL
2014Butcher NE, D'Este C, Balogh ZJ, 'The quest for a universal definition of polytrauma: a trauma registry-based validation study.', J Trauma Acute Care Surg, 77 620-623 (2014) [C1]
DOI10.1097/TA.0000000000000404Author URL
Co-authorsCatherine Deste
2014Sartelli M, Catena F, Ansaloni L, Coccolini F, Corbella D, Moore EE, et al., 'Complicated intra-abdominal infections worldwide: The definitive data of the CIAOW Study', World Journal of Emergency Surgery, 9 (2014) [C1]

The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a... [more]

The CIAOW study (Complicated intra-abdominal infections worldwide observational study) is a multicenter observational study underwent in 68 medical institutions worldwide during a six-month study period (October 2012-March 2013). The study included patients older than 18 years undergoing surgery or interventional drainage to address complicated intra-abdominal infections (IAIs).1898 patients with a mean age of 51.6 years (range 18-99) were enrolled in the study. 777 patients (41%) were women and 1,121 (59%) were men. Among these patients, 1,645 (86.7%) were affected by community-acquired IAIs while the remaining 253 (13.3%) suffered from healthcare-associated infections. Intraperitoneal specimens were collected from 1,190 (62.7%) of the enrolled patients.827 patients (43.6%) were affected by generalized peritonitis while 1071 (56.4%) suffered from localized peritonitis or abscesses.The overall mortality rate was 10.5% (199/1898).According to stepwise multivariate analysis (PR = 0.005 and PE = 0.001), several criteria were found to be independent variables predictive of mortality, including patient age (OR = 1.1; 95%CI = 1.0-1.1; p < 0.0001), the presence of small bowel perforation (OR = 2.8; 95%CI = 1.5-5.3; p < 0.0001), a delayed initial intervention (a delay exceeding 24 hours) (OR = 1.8; 95%CI = 1.5-3.7; p < 0.0001), ICU admission (OR = 5.9; 95%CI = 3.6-9.5; p < 0.0001) and patient immunosuppression (OR = 3.8; 95%CI = 2.1-6.7; p < 0.0001). © 2014 Sartelli et al.; licensee BioMed Central Ltd.

DOI10.1186/1749-7922-9-37
CitationsScopus - 6Web of Science - 5
2014Weber DG, Bendinelli C, Balogh ZJ, 'Damage control surgery for abdominal emergencies', British Journal of Surgery, 101 (2014) [C1]

Background: Damage control surgery is a management sequence initiated to reduce the risk of death in severely injured patients presenting with physiological derangement. Damage co... [more]

Background: Damage control surgery is a management sequence initiated to reduce the risk of death in severely injured patients presenting with physiological derangement. Damage control principles have emerged as an approach in non-trauma abdominal emergencies in order to reduce mortality compared with primary definitive surgery. Methods: A PubMed/MEDLINE literature review was conducted of data available over the past decade (up to August 2013) to gain information on current understanding of damage control surgery for abdominal surgical emergencies. Future directions for research are discussed. Results: Damage control surgery facilitates a strategy for life-saving intervention for critically ill patients by abbreviated laparotomy with subsequent reoperation for delayed definitive repair after physiological resuscitation. The six-phase strategy (including damage control resuscitation in phase 0) is similar to that for severely injured patients, although non-trauma indications include shock from uncontrolled haemorrhage or sepsis. Minimal evidence exists to validate the benefit of damage control surgery in general surgical abdominal emergencies. The collective published experience over the past decade is limited to 16 studies including a total of 455 (range 3-99) patients, of which the majority are retrospective case series. However, the concept has widespread acceptance by emergency surgeons, and appears a logical extension from pathophysiological principles in trauma to haemorrhage and sepsis. The benefits of this strategy depend on careful patient selection. Damage control surgery has been performed for a wide range of indications, but most frequently for uncontrolled bleeding during elective surgery, haemorrhage from complicated gastroduodenal ulcer disease, generalized peritonitis, acute mesenteric ischaemia and other sources of intra-abdominal sepsis. Conclusion: Damage control surgery is employed in a wide range of abdominal emergencies and is an increasingly recognized life-saving tactic in emergency surgery performed on physiologically deranged patients. © 2013 BJS Society Ltd.

DOI10.1002/bjs.9360
CitationsScopus - 8Web of Science - 4
2014Easton R, Balogh ZJ, 'Peri-operative changes in serum immune markers after trauma: A systematic review', Injury, (2014) [C1]
CitationsScopus - 6Web of Science - 4
2014Lumsdaine W, Easton RM, Lott NJ, White A, Malmanche TLD, Lemmert K, et al., 'Neutrophil oxidative burst capacity for peri-operative immune monitoring in trauma patients', Injury, (2014) [C1]

Background: Post injury immune dysfunction can result in serious complications. Measurement of biomarkers may guide the optimal timing of surgery in clinically borderline patients... [more]

Background: Post injury immune dysfunction can result in serious complications. Measurement of biomarkers may guide the optimal timing of surgery in clinically borderline patients and therefore prevent complications. Aim: peri-operative measurement of neutrophil oxidative burst capacity as an indicator of the immune response to major orthopaedic surgical procedures. Methods: Prospective cohort study of trauma patients aged =16 yrs with pelvic, acetabular, femoral shaft or tibial shaft fractures requiring surgical intervention. Blood samples were taken immediately pre-op and at 30 min, 7, 24 and 72-96 h post-operatively. Neutrophil oxidative burst capacity was measured both with and without stimulation by formyl-methionyl-leucyl-phenylalanine (fMLP, a chemotactic factor). Clinical outcomes measured were mortality, length of stay, MOF, pneumonia, acute respiratory distress syndrome (ARDS) and sepsis. Results: 100 consecutive orthopaedic trauma patients were enrolled over a 16 month period. 78% were male, with a mean age of 42 ± 18 years and an average ISS of 19 ± 13. Neutrophil oxidative burst capacity was significantly elevated at 7 h (p = 0.006) and 24 h (p = 0.022) post operatively. Patients who developed infective complications (pneumonia and sepsis) had higher levels of oxidative burst capacity pre-operatively (pneumonia: 1.52 ± 0.93 v 0.99 ± 0.66 p = 0.032, sepsis: 1.39 ± 0.86 v 0.97 ± 0.56 p = 0.024) and at 24 h post op (pneumonia: 2.72 ± 2.38 v 1.12 ± 0.63 p = <0.001, sepsis: 2.16 ± 2.09 v 1.10 ± 0.54 p = <0.001). When analysed by operation type, no statistical difference was seen between major and minor operations. No correlation was found between length of stay, length of ICU stay, ISS or age and neutrophil oxidative burst capacity at any time point. Conclusions: Neutrophil oxidative burst capacity response to orthopaedic trauma surgery is associated with the infective post injury complications. There was no correlation between magnitude of injury or operation and oxidative burst capacity. These results are promising for the development of tools for prediction of post-operative complications and guidance for optimal timing for surgical intervention. © 2014 Elsevier Ltd. All rights reserved.

DOI10.1016/j.injury.2014.04.019
2014Tay W-H, de Steiger R, Richardson M, Gruen R, Balogh ZJ, 'Health outcomes of delayed union and nonunion of femoral and tibial shaft fractures', Injury, (2014) [C1]

Introduction: Knowledge about the functional consequences of lower limb long bone fractures is helpful to inform patients, clinicians and employers about their recovery process an... [more]

Introduction: Knowledge about the functional consequences of lower limb long bone fractures is helpful to inform patients, clinicians and employers about their recovery process and prognosis. This study aims to describe the epidemiology and health outcomes of femoral and tibial shaft fractures treated at two level I trauma centres, by comparing the differences between patients with delayed union or nonunion and patients with union. Patients and methods: An analysis of registry data over two years, supplemented with medical record review, was conducted. Fracture healing was retrospectively assessed by clinical and radiological evidence of union, and the need for surgical intervention. SF-12 scores, and work and pain status were prospectively recorded at six and twelve months post injury. Results: 285 fractures progressed to union and 138 fractures developed delayed union or nonunion. There was a significant difference between the two cohorts with regards to the mechanism of injury, association with multi-trauma, open fractures, grade of Gustilo classification, patient fund source, smoking status and presence of comorbidities. The SF-12 physical component score was less than 50 at both six and twelve months with improvement in the union group, but not in the delayed union or nonunion group. 72% of patients with union had returned to work at one year, but 54% continued to have pain. The difference compared to patients with delayed union or nonunion was significant. Discussion: Even patients whose fractures unite in the expectant time-frame will have residual physical disability. Patients with delayed union or nonunion have still poorer outcomes, including ongoing problems with returning to work and pain. It is important to educate patients about their injury so that they have realistic expectations. This is particularly relevant given that the patients most likely to sustain femoral or tibial shaft fractures are working-age healthy adults, and up to a third of fractures may develop delayed union or nonunion. Conclusion: Despite modern treatment, the patient-reported outcomes of lower limb long bone shaft fractures do not return to normal at one year. Patients with delayed union or nonunion can expect poorer outcomes. © 2014 Elsevier Ltd. All rights reserved.

DOI10.1016/j.injury.2014.06.025
2014Tay W-H, De Steiger R, Richardson M, Gruen R, Balogh ZJ, 'Health outcomes of delayed union and nonunion of femoral and tibial shaft fractures', Injury, 45 1653-1658 (2014) [C1]

Introduction: Knowledge about the functional consequences of lower limb long bone fractures is helpful to inform patients, clinicians and employers about their recovery process an... [more]

Introduction: Knowledge about the functional consequences of lower limb long bone fractures is helpful to inform patients, clinicians and employers about their recovery process and prognosis. This study aims to describe the epidemiology and health outcomes of femoral and tibial shaft fractures treated at two level I trauma centres, by comparing the differences between patients with delayed union or nonunion and patients with union. Patients and methods: An analysis of registry data over two years, supplemented with medical record review, was conducted. Fracture healing was retrospectively assessed by clinical and radiological evidence of union, and the need for surgical intervention. SF-12 scores, and work and pain status were prospectively recorded at six and twelve months post injury. Results: 285 fractures progressed to union and 138 fractures developed delayed union or nonunion. There was a significant difference between the two cohorts with regards to the mechanism of injury,association with multi-trauma, open fractures, grade of Gustilo classification, patient fund source, smoking status and presence of comorbidities. The SF-12 physical component score was less than 50 at both six and twelve months with improvement in the union group, but not in the delayed union or nonunion group. 72% of patients with union had returned to work at one year, but 54% continued to have pain. The difference compared to patients with delayed union or nonunion was significant. Discussion: Even patients whose fractures unite in the expectant time-frame will have residual physical disability. Patients with delayed union or nonunion have still poorer outcomes, including ongoing problems with returning to work and pain. It is important to educate patients about their injury so that they have realistic expectations. This is particularly relevant given that the patients most likely to sustain femoral or tibial shaft fractures are working-age healthy adults, and up to a third of fractures may develop delayed union or nonunion. Conclusion: Despite modern treatment, the patient-reported outcomes of lower limb long bone shaft fractures do not return to normal at one year. Patients with delayed union or nonunion can expect poorer outcomes.

DOI10.1016/j.injury.2014.06.025
2014Balogh ZJ, Lumsdaine W, Moore EE, Moore FA, 'Postinjury abdominal compartment syndrome: from recognition to prevention', LANCET, 384 1466-1475 (2014) [C1]
Author URL
CitationsScopus - 1
2014Verbeek DO, Sugrue M, Balogh Z, Cass D, Civil I, Harris I, et al., 'Erratum to: Acute Management of Hemodynamically Unstable Pelvic Trauma Patients: Time for a Change? Multicenter Review of Recent Practice', World Journal of Surgery, (2014) [O1]
DOI10.1007/s00268-014-2657-1
2014McIlroy DJ, Jarnicki AG, Au GG, Lott N, Smith DW, Hansbro PM, Balogh ZJ, 'Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery', Journal of Critical Care, 29 1133.e1-1133.e5 (2014)
DOI10.1016/j.jcrc.2014.07.013
Co-authorsDouglas Smith, Gough Au, Philip Hansbro
2014McIlroy DJ, Jarnicki AG, Au GG, Lott N, Smith DW, Hansbro PM, Balogh ZJ, 'Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery', Journal of Critical Care, 29 1133.e1-1133.e5 (2014) [C1]

Introduction: Neutrophil extracellular traps (NETs) have not been demonstrated after trauma and subsequent surgery. Neutrophil extracellular traps are formed from pure mitochondri... [more]

Introduction: Neutrophil extracellular traps (NETs) have not been demonstrated after trauma and subsequent surgery. Neutrophil extracellular traps are formed from pure mitochondrial DNA (mtDNA) under certain conditions, which is potently proinflammatory. We hypothesized that injury and orthopedic trauma surgery would induce NET production with mtDNA as a structural component. Methods: Neutrophils were isolated 8 trauma patients requiring orthopedic surgery postinjury and up to 5 days postoperatively. Four healthy volunteers provided positive and negative controls. Total hip replacement patients acted as an uninjured surgical control group. Neutrophil extracellular traps were visualized with DNA (Hoechst 33342TM/Sytox Green/MitoSox/MitoTracker) stains using live cell fluorescence microscopy with downstream quantitative polymerase chain reaction analysis of DNA composition. Results: Neutrophil extracellular traps were present after injury in all 8 trauma patients. They persisted for 5 days postoperatively. Delayed surgery resulted in NET resolution, but they reformed postoperatively. Total hip replacement patients developed NETs postoperatively, which resolved by day 5. Quantitative polymerase chain reaction analysis of NET-DNA composition revealed that NETs formed after injury and surgery were made of mtDNA with no detectable nuclear DNA component. Conclusions: Neutrophil extracellular traps formed after major trauma and subsequent surgery contain mtDNA and represent a novel marker of heightened innate immune activation. They could be considered when timing surgery after trauma to prevent systemic NET-induced inflammatory complications.

DOI10.1016/j.jcrc.2014.07.013
CitationsScopus - 3
Co-authorsGough Au, Philip Hansbro, Douglas Smith
2014Toth L, King KL, McGrath B, Balogh ZJ, 'Factors associated with pelvic fracture-related arterial bleeding during trauma resuscitation: A prospective clinical study', Journal of Orthopaedic Trauma, 28 489-495 (2014) [C1]
DOI10.1097/BOT.0000000000000056
2014Neptune D, Bonevski B, Enninghorst N, Balogh ZJ, 'The prevalence of smoking and interest in quitting among surgical patients with acute extremity fractures', Drug and Alcohol Review, (2014) [C1]

Introduction and Aims: We studied the prevalence of smoking, the effect of hospital stay on motivation to quit and the exposure to smoking cessation advice in orthopaedic patients... [more]

Introduction and Aims: We studied the prevalence of smoking, the effect of hospital stay on motivation to quit and the exposure to smoking cessation advice in orthopaedic patients who required surgical intervention for acute extremity fractures. Design and Methods: This cross-sectional study involved a self-administered pen-and-paper survey assessing smoking status, interest and motivation to quit smoking, and current advice to quit among a consecutive cohort of patients aged 18-65 years old with acute extremity fractures. These patients were admitted to the John Hunter Hospital Level 1 trauma facility in New South Wales, Australia, for surgical intervention over a three month period. Results: A total of 183 patients (response rate 98%) completed the survey. Sixty-eight patients (37.2%) reported a current smoking habit. The prevalence of smoking was 42.2% among males and 25.5% among females. A total of 40% of smokers reported that they had not received advice to quit from medical staff during hospital admission. Prior to admission, 12.1% of smokers were interested in smoking cessation; this percentage increased to 26.8% post-admission. Discussion and Conclusions: The prevalence of smoking among surgical patients with extremity fractures was found to be more than twice the prevalence of the population of New South Wales. Hospital admission had a positive impact on the patient's interest in smoking cessation. Our study suggests that the identification of orthopaedic patients who smoke is suboptimal, and the opportunity to encourage smoking cessation during hospital admission is currently being overlooked. © 2014 Australasian Professional Society on Alcohol and other Drugs.

DOI10.1111/dar.12170
Co-authorsBillie Bonevski
2014Balogh ZJ, 'Trauma verification: for the trauma centre or for the trauma system?', ANZ JOURNAL OF SURGERY, 84 499-500 (2014) [C3]
DOI10.1111/ans.12573Author URL
2014Tarrant SM, Hardy BM, Balogh ZJ, 'Repair of traumatic muscle herniation with acellular porcine collagen matrix', ANZ Journal of Surgery, 84 464-467 (2014)
DOI10.1111/ans.12200
2014Tarrant SM, Hardy BM, Balogh ZJ, 'Repair of traumatic muscle herniation with acellular porcine collagen matrix', ANZ Journal of Surgery, 84 464-467 (2014) [C1]

Background: Muscle hernias are uncommon clinical conditions with no uniform solution of repair. Biocompatible mesh allows for repair of hernias without the donor site morbidity an... [more]

Background: Muscle hernias are uncommon clinical conditions with no uniform solution of repair. Biocompatible mesh allows for repair of hernias without the donor site morbidity and complications from direct repair under tension. Methods: Over a 6-month period at a Level 1 Trauma centre, four consecutive symptomatic muscle hernias were identified, two in the forearm and two in the lower limb. Three resulted from high-speed motorbike accidents, one from a mining accident. All patients had hernia repair at a minimum of 4 months post accident. A 10×15cm×1.0mm sheet of acellular collagen matrix was fashioned to fit as an underlay of the fascia defect. Patients were clinically followed at the 2-, 6-, 12- and 26-week mark. Final phone contact was made 18 months post-operatively. Results: All patients were pleased with their cosmetic and functional outcomes. All patients returned to work and sport 3 months after reconstruction. Conclusion: Symptomatic hernias as a result of trauma can be safely reconstructed with a biological mesh implant. This approach can prevent complications from previously described methods and return to active lifestyles with good results. © 2013 Royal Australasian College of Surgeons.

DOI10.1111/ans.12200
2014Butcher NE, Balogh ZJ, 'Update on the definition of polytrauma', European Journal of Trauma and Emergency Surgery, (2014) [C1]

Purpose The definition and use of the term "polytrauma" is inconsistent and lacks validation. This article describes the historical evolution of the term and geographical differen... [more]

Purpose The definition and use of the term "polytrauma" is inconsistent and lacks validation. This article describes the historical evolution of the term and geographical differences in its meaning, examines the challenges faced in defining it adequately in the current context, and summarizes where the international consensus process is heading, in order to provide the trauma community with a validated and universally agreed upon definition of polytrauma. Conclusion A lack of consensus in the definition of "polytrauma" was apparent. According to the international consensus opinion, both anatomical and physiological parameters should be included in the definition of polytrauma. An Abbreviated Injury Scale (AIS) based anatomical definition is the most practical and feasible given the ubiquitous use of the system. Convincing preliminary data show that two body regions with AIS >2 is a good marker of polytrauma-better than other ISS cutoffs, which could also indicate monotrauma. The selection of the most accurate physiological parameters is still underway, but they will most likely be descriptors of tissue hypoxia and coagulopathy. © 2014 Springer-Verlag Berlin Heidelberg.

DOI10.1007/s00068-014-0391-x
2014Tarrant SM, Hardy BM, Byth PL, Brown TL, Attia J, Balogh ZJ, 'Preventable mortality in geriatric hip fracture inpatients', Bone and Joint Journal, 69B 1178-1184 (2014)
DOI10.1302/0301-620X.96B9.32814$2.00
CitationsScopus - 1
Co-authorsJohn Attia
2014Tarrant SM, Hardy BM, Byth PL, Brown TL, Attia J, Balogh ZJ, 'Preventable mortality in geriatric hip fracture inpatients', Bone and Joint Journal, 69B 1178-1184 (2014) [C1]

There is a high rate of mortality in elderly patients who sustain a fracture of the hip. We aimed to determine the rate of preventable mortality and errors during the management o... [more]

There is a high rate of mortality in elderly patients who sustain a fracture of the hip. We aimed to determine the rate of preventable mortality and errors during the management of these patients. A 12 month prospective study was performed on patients aged > 65 years who had sustained a fracture of the hip. This was conducted at a Level 1 Trauma Centre with no orthogeriatric service. A multidisciplinary review of the medical records by four specialists was performed to analyse errors of management and elements of preventable mortality. During 2011, there were 437 patients aged > 65 years admitted with a fracture of the hip (85 years (66 to 99)) and 20 died while in hospital (86.3 years (67 to 96)). A total of 152 errors were identified in the 80 individual reviews of the 20 deaths. A total of 99 errors (65%) were thought to have at least a moderate effect on death; 45 reviews considering death (57%) were thought to have potentially been preventable. Agreement between the panel of reviewers on the preventability of death was fair. A larger-scale assessment of preventable mortality in elderly patients who sustain a fracture of the hip is required. Multidisciplinary review panels could be considered as part of the quality assurance process in the management of these patients.

DOI10.1302/0301-620X.96B9.32814$2.00
CitationsScopus - 4Web of Science - 3
Co-authorsJohn Attia
2014Cryer HG, Rhee P, Dr H, Balogh ZJ, Sauaia A, 'Temporal trends of postinjury multiple-organ failure: Still resource intensive, morbid, and lethal DISCUSSION', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 76 592-593 (2014) [C1]
Author URL
CitationsWeb of Science - 1
2014White AE, Edelman JJB, Lott N, Bannon PG, McElduff P, Curnow JL, Balogh ZJ, 'Characterization of the hypercoagulable state following severe orthopedic trauma', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 77 231-237 (2014) [C1]
DOI10.1097/TA.0000000000000311Author URL
2014Pape H-C, Lefering R, Butcher N, Peitzman A, Leenen L, Marzi I, et al., 'The definition of polytrauma revisited: An international consensus process and proposal of the new 'Berlin definition'', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 77 780-786 (2014) [C1]
DOI10.1097/TA.0000000000000453Author URL
CitationsScopus - 1Web of Science - 1
2014Dewar DC, White A, Attia J, Tarrant SM, King KL, Balogh ZJ, 'Comparison of postinjury multiple-organ failure scoring systems: Denver versus sequential organ failure assessment', Journal of Trauma and Acute Care Surgery, 77 624-629 (2014) [C1]

BACKGROUND: The Denver and Sequential Organ Failure Assessment (SOFA) scores have been used widely to describe the epidemiology of postinjury multiple-organ failure; however, diff... [more]

BACKGROUND: The Denver and Sequential Organ Failure Assessment (SOFA) scores have been used widely to describe the epidemiology of postinjury multiple-organ failure; however, differences in these scores make it difficult to compare incidence, duration, and mortality of multiple-organ failure. The study aim was to compare the performance of the Denver and SOFA scores with respect to the outcomes of mortality, intensive care unit length of stay (ICU LOS), and ventilator days.

DOI10.1097/TA.0000000000000406
Co-authorsJohn Attia
2014McIlroy DJ, Jarnicki AG, Au GG, Lott N, Smith DW, Hansbro PM, Balogh ZJ, 'Mitochondrial DNA neutrophil extracellular traps are formed after trauma and subsequent surgery.', Journal of critical care, 29 1133.e1-1133.e5 (2014) [C1]
DOI10.1016/j.jcrc.2014.07.013
CitationsScopus - 1
Co-authorsGough Au, Douglas Smith, Philip Hansbro
2014Balogh ZJ, 'Publishing trauma-related topics in ANZ Journal of Surgery.', ANZ J Surg, 84 399-400 (2014) [C3]
DOI10.1111/ans.12572Author URL
2014Tarrant SM, Hardy BM, Byth PL, Brown TL, Attia J, Balogh ZJ, 'Preventable mortality in geriatric hip fracture inpatients', Bone and Joint Journal, 96B 1178-1184 (2014) [C1]

There is a high rate of mortality in elderly patients who sustain a fracture of the hip. We aimed to determine the rate of preventable mortality and errors during the management o... [more]

There is a high rate of mortality in elderly patients who sustain a fracture of the hip. We aimed to determine the rate of preventable mortality and errors during the management of these patients. A 12 month prospective study was performed on patients aged > 65 years who had sustained a fracture of the hip. This was conducted at a Level 1 Trauma Centre with no orthogeriatric service. A multidisciplinary review of the medical records by four specialists was performed to analyse errors of management and elements of preventable mortality. During 2011, there were 437 patients aged > 65 years admitted with a fracture of the hip (85 years (66 to 99)) and 20 died while in hospital (86.3 years (67 to 96)). A total of 152 errors were identified in the 80 individual reviews of the 20 deaths. A total of 99 errors (65%) were thought to have at least a moderate effect on death; 45 reviews considering death (57%) were thought to have potentially been preventable. Agreement between the panel of reviewers on the preventability of death was fair. A larger-scale assessment of preventable mortality in elderly patients who sustain a fracture of the hip is required. Multidisciplinary review panels could be considered as part of the quality assurance process in the management of these patients.

DOI10.1302/0301-620X.96B9.32814
Co-authorsJohn Attia
2013Butcher NE, Balogh ZJ, 'The practicality of including the systemic inflammatory response syndrome in the definition of polytrauma: Experience of a level one trauma centre', INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 44 12-17 (2013) [C1]
DOI10.1016/j.injury.2012.04.019Author URL
CitationsScopus - 4Web of Science - 4
2013Lumsdaine W, Enninghorst N, Hardy BM, Balogh ZJ, 'Patterns of CT use and surgical intervention in upper limb periarticular fractures at a level-1 trauma centre', INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 44 471-474 (2013) [C1]
DOI10.1016/j.injury.2012.09.028Author URL
CitationsScopus - 1Web of Science - 1
2013Sisak K, Manolis M, Hardy BM, Enninghorst N, Bendinelli C, Balogh ZJ, 'Acute transfusion practice during trauma resuscitation: Who, when, where and why?', INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 44 581-586 (2013) [C1]
DOI10.1016/j.injury.2012.08.031Author URL
CitationsScopus - 6Web of Science - 7
2013Bendinelli C, Bivard A, Nebauer S, Parsons MW, Balogh ZJ, 'Brain CT perfusion provides additional useful information in severe traumatic brain injury', INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 44 1208-1212 (2013) [C1]
DOI10.1016/j.injury.2013.03.039Author URL
CitationsScopus - 3Web of Science - 1
Co-authorsMark Parsons
2013Soederlund T, Yoshino O, Bendinelli C, Enninghorst N, Balogh ZJ, 'Acute repair of traumatic abdominal muscle avulsion from iliac crest: A mesh-free technique using suture anchors', INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 44 1257-1259 (2013) [C3]
DOI10.1016/j.injury.2013.03.028Author URL
2013Burge K, Balogh Z, 'Striving for excellence', MEDICAL JOURNAL OF AUSTRALIA, 198 C5-C5 (2013) [C3]
Author URL
2013Kirkpatrick AW, Roberts DJ, De Waele J, Jaeschke R, Malbrain MLNG, De Keulenaer B, et al., 'Intra-abdominal hypertension and the abdominal compartment syndrome: updated consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome', INTENSIVE CARE MEDICINE, 39 1190-1206 (2013) [C1]
DOI10.1007/s00134-013-2906-zAuthor URL
CitationsScopus - 91Web of Science - 78
2013Balogh ZJ, McIlroy DJ, Smith DW, Hansbro PM, 'The origin and the role of mitochondrial DNA in postinjury inflammation', Journal of Critical Care, 28 1099-1100 (2013) [C3]
DOI10.1016/j.jcrc.2013.08.027
CitationsScopus - 2Web of Science - 2
Co-authorsPhilip Hansbro, Douglas Smith
2013Sisak K, Manolis M, Hardy BM, Enninghorst N, Balogh ZJ, 'Epidemiology of Acute Transfusions in Major Orthopaedic Trauma', JOURNAL OF ORTHOPAEDIC TRAUMA, 27 413-418 (2013) [C1]
DOI10.1097/BOT.0b013e31827d7f30Author URL
CitationsScopus - 1
2013Mitchell RJ, Curtis K, Holland AJ, Balogh ZJ, Evans J, Wilson KL, 'Acute costs and predictors of higher treatment costs for major paediatric trauma in New South Wales, Australia', Journal of Paediatrics and Child Health, 49 557-563 (2013) [C1]

Aims To describe the costs of acute trauma admissions for children aged =15 years in trauma centres; to identify predictors of higher treatment costs and quantify differences in a... [more]

Aims To describe the costs of acute trauma admissions for children aged =15 years in trauma centres; to identify predictors of higher treatment costs and quantify differences in actual and state-wide average cost in New South Wales (NSW), Australia. Method Admitted trauma patient data provided by 12 trauma centres was linked with financial data for 2008-2009. Demographic, injury details and injury severity scores (ISS) were obtained from trauma registries. Individual patient costs, Australian Refined Diagnostic Related Groups (AR-DRG) and state-wide average costs were obtained. Actual costs incurred by each hospital were compared with state-wide AR-DRG average costs. Multivariate multiple linear regression identified predictors of cost. Results There were 3493 patients with a total cost of AUD$20.2 million. Falls (AUD$6.7 million) and road trauma (AUD$4.4 million) had the highest total expenditure. The reduction in cost between ISS < 9 compared to ISS 9-12 and ISS > 12 was significant (P < 0.0001). The median cost of injury increased with every additional body region injured (P < 0.0001). For each additional day spent in hospital, there was an increased cost of AUD$1898 and patients admitted to an intensive care unit (ICU) cost AUD$7358 more than patients not admitted to ICU. The total costs incurred by trauma centres were AUD$1.4 million above the NSW peer group average cost estimates. Conclusions The high financial cost of paediatric patient treatment highlights the need to ensure prevention remains a priority in Australia. Hospitals tasked with providing trauma care should be appropriately funded and future funding models should consider trauma severity. © 2013 The Authors. Journal of Paediatrics and Child Health © 2013 Paediatrics and Child Health Division (Royal Australasian College of Physicians).

DOI10.1111/jpc.12280
CitationsScopus - 1Web of Science - 1
2013Balogh ZJ, 'Severe trauma in elderly patients', ANZ JOURNAL OF SURGERY, 83 2-3 (2013) [C3]
DOI10.1111/ans.12034Author URL
CitationsWeb of Science - 1
2013Balogh ZJ, Fischer A, 'Potential preventive measures against quad bike injuries', ANZ JOURNAL OF SURGERY, 83 198-198 (2013) [C3]
DOI10.1111/ans.12105Author URL
2013Balogh ZJ, Balogh R, 'Practical Management of Head and Neck Injury. Edited by J. V. Rosenfeld . Sydney: Churchill Livingstone, 2012. Illustrations: > 250 colour and black and whites. Page count: XII and 389 pages. ISBN 9780729539562. Price: $150.00.', ANZ JOURNAL OF SURGERY, 83 393-393 (2013) [C3]
DOI10.1111/ans.12113Author URL
2013Hunt JJ, Lumsdaine W, Attia J, Balogh ZJ, 'AO type-C distal radius fractures: the influence of computed tomography on surgeon's decision-making', ANZ JOURNAL OF SURGERY, 83 676-678 (2013) [C3]
DOI10.1111/j.1445-2197.2012.06311.xAuthor URL
CitationsScopus - 1Web of Science - 1
Co-authorsJohn Attia
2013O'Reilly-Harbidge SC, Balogh ZJ, 'Three-point suture anchor repair of traumatic sternoclavicular joint dislocation', ANZ JOURNAL OF SURGERY, 83 883-886 (2013) [C1]
DOI10.1111/ans.12403Author URL
2013Hardy BM, Chan S, Martin AB, Brieva J, Gallagher A, Sokolowsky A, Balogh ZJ, 'Temperature change in the helicopter transport of trauma patients', ANZ JOURNAL OF SURGERY, 83 894-895 (2013) [C3]
DOI10.1111/ans.12138Author URL
2013Sartelli M, Catena F, Ansaloni L, Moore E, Malangoni M, Velmahos G, et al., 'Complicated intra-abdominal infections in a worldwide context: an observational prospective study (CIAOW Study)', WORLD JOURNAL OF EMERGENCY SURGERY, 8 (2013) [C1]
DOI10.1186/1749-7922-8-1Author URL
CitationsScopus - 9Web of Science - 8
2013Sartelli M, Viale P, Catena F, Ansaloni L, Moore E, Malangoni M, et al., '2013 WSES guidelines for management of intra-abdominal infections', WORLD JOURNAL OF EMERGENCY SURGERY, 8 (2013) [C2]
DOI10.1186/1749-7922-8-3Author URL
CitationsScopus - 24Web of Science - 23
2013Balogh ZJ, Weber DG, 'Polytrauma and Organ Crosstalk', ICU Management, 13 - (2013) [C3]
2013Mitchell RJ, Bambach MR, Muscatello D, McKenzie K, Balogh ZJ, 'Can SNOMED CT as implemented in New South Wales, Australia be used for road trauma injury surveillance in emergency departments?', Health Information Management Journal, 42 4-8 (2013) [C1]

The introduction of Systematized Nomenclature of Medicine - Clinical Terms (SNOMED CT) for diagnosis coding in emergency departments (EDs) in New South Wales (NSW) has implication... [more]

The introduction of Systematized Nomenclature of Medicine - Clinical Terms (SNOMED CT) for diagnosis coding in emergency departments (EDs) in New South Wales (NSW) has implications for injury surveillance abilities. This study aimed to assess the consequences of its introduction, as implemented as part of the ED information system in NSW, for identifying road trauma-related injuries in EDs. It involved a retrospective analysis of road trauma-related injuries identified in linked police, ED and mortality records during March 2007 to December 2009. Of all SNOMED CT codes in the principal provisional diagnosis field, between 53.7% and 78.4% referred to the type of injury or symptom experienced by the individual. Of the road users identified by police, 3.2% of vehicle occupants, 6% of motorcyclists, 10.0% of pedal cyclists and 5.2% of pedestrians were identified using SNOMED CT codes in the principal provisional diagnosis field. The introduction of SNOMED CT may provide flexible terminologies for clinicians. However, unless carefully implemented in information systems, its flexibility can lead to mismatches between the intention and actual use of defined data fields. Choices available in SNOMED CT to indicate symptoms, diagnoses, or injury mechanisms need to be controlled and these three concepts need to be retained in separate data fields to ensure a clear distinction between their classifications in the ED.

2013Williams N, Hardy BM, Tarrant S, Enninghorst N, Attia J, Oldmeadow C, Balogh ZJ, 'Changes in hip fracture incidence, mortality and length of stay over the last decade in an Australian major trauma centre.', Archives of Osteoporosis, 8 (2013) [C1]
DOI10.1007/s11657-013-0150-3
CitationsScopus - 8
Co-authorsJohn Attia, Christopher Oldmeadow
2013Enninghorst N, Hardy BM, Sisak K, Lott N, Balogh ZJ, 'Tissue oxygen saturation changes during intramedullary nailing of lower-limb fractures', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 74 123-127 (2013) [C1]
DOI10.1097/TA.0b013e3182788e6cAuthor URL
2013Dewar DC, Tarrant SM, King KL, Balogh ZJ, 'Changes in the epidemiology and prediction of multiple-organ failure after injury', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 74 774-779 (2013) [C1]
DOI10.1097/TA.0b013e31827a6e69Author URL
CitationsScopus - 11Web of Science - 14
2013Wong TH, Lumsdaine W, Hardy BM, Balogh ZJ, 'The impact of specialist trauma service on major trauma mortality', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 74 780-784 (2013) [C1]
DOI10.1097/TA.0b013e3182826d5fAuthor URL
CitationsScopus - 5Web of Science - 5
2013Butcher NE, Enninghorst N, Sisak K, Balogh ZJ, 'The definition of polytrauma: Variable interrater versus intrarater agreement-A prospective international study among trauma surgeons', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 74 884-889 (2013) [C1]
DOI10.1097/TA.0b013e31827e1badAuthor URL
CitationsScopus - 3Web of Science - 4
2013Enninghorst N, McDougall D, Evans JA, Sisak K, Balogh ZJ, 'Population-based epidemiology of femur shaft fractures', Journal of Trauma and Acute Care Surgery, 74 1516-1520 (2013) [C1]

BACKGROUND: Themanagement of patientswith femoral shaft fractures (FSFs) is often a decisionmaking dilemma (damage-control orthopedics vs. early total care), with equivocal eviden... [more]

BACKGROUND: Themanagement of patientswith femoral shaft fractures (FSFs) is often a decisionmaking dilemma (damage-control orthopedics vs. early total care), with equivocal evidence. The comprehensive, population-based epidemiology of patients with FSF is unknown. The purpose of this prospective study was to describe the epidemiology of patientswith FSF, with special focus on patient physiology and timing of surgery. METHODS: A 12-month prospective population-based study was performed on consecutive patients with FSF in an area with 850,000 population including all ages and prehospital deaths. Patient demographics, mechanism, Injury Severity Score (ISS), shock parameters (systolic blood pressure, base deficit and lactate), transfusion requirement, fracture type [Arbeitsgemeinschaft für Osteosynthesefragen/Orthopaedic Trauma Association classification (OA/OTA)], comorbidities, procedures, and outcomes were recorded. Patients hemodynamic status was described as stable, borderline, unstable, and "in extremis." RESULTS: Atotal of 126 patients (21 per 100,000 per year)with 136 femur fractures (62%male; age, 38 [28] years; ISS, 20 [19]; 51%multiple injuries) were identified in the region. Sixty patients (48.4%) sustained a high-energy injury with 19 (31.1%) of these being polytrauma patients (ISS, 28 [12]; systolic blood pressure, 98 [39]; base deficit, 6.5 [5.8]; lactate 4 [2]).Fifteen polytrauma patients (94%) required massive transfusion (12 [12] U of packed red blood cells, 8 [5] fresh frozen plasma, 1 [0.4] platelet, 13 [8] cryoprecipitate). Twenty-one patients (16.7%) died at the prehospital setting (3.5 per 100,000 per year). From the 105 hospital admissions, 68.3% was stable (14.3 per 100,000 per year), 8.7% was borderline (1.8 per 100,000 per year), 4.0% was unstable (0.8 per 100,000 per year) and 2.4%(0.5 per 100,000 per year)was in extremis. Six patients (5.7%) died. The length of stay (LOS) was 18 (15) days, and the intensive care unit LOS was 5 (6) days. Fourty-five patients sustained a low-energy injury that had in 85%of casesmultiple comorbidities. Eight low-energy patients needed 3 (1) transfusions, and none of the patients died. The LOS was 15 (11) days. CONCLUSION: Patients with low-energy FSF have a hospital admission rate similar to the patients with high-energy FSF. Sixty-eight percent of patients with FSF are complicated (open, compromised physiology, multiple injuries, bilateral, elderly with comorbidities, etc.), requiring major resources and highly specialized care. LEVEL OF EVIDENCE: Epidemiology study, level III. Copyright © 2013 Lippincott Williams & Wilkins.

DOI10.1097/TA.0b013e31828c3dc9
CitationsScopus - 3Web of Science - 3
2012Butcher NE, Balogh ZJ, 'AIS > 2 in at least two body regions: A potential new anatomical definition of polytrauma', Injury, 43 196-199 (2012) [C1]
CitationsScopus - 15Web of Science - 15
2012Van Wessem KJP, Mackay PJ, King KL, Balogh ZJ, 'Selective faecal diversion in open pelvic fractures: Reassessment based on recent experience', Injury-International Journal of the Care of the Injured, 43 522-525 (2012) [C3]
2012Toth L, King KL, McGrath B, Balogh ZJ, 'Efficacy and safety of emergency non-invasive pelvic ring stabilisation', Injury: International Journal of the Care of the Injured, 43 1330-1334 (2012) [C1]
CitationsScopus - 1Web of Science - 1
2012Easton RM, Bendinelli C, Sisak K, Enninghorst N, Regan D, Evans J, Balogh ZJ, 'Recalled pain scores are not reliable after acute trauma', Injury: International Journal of the Care of the Injured, 43 1029-1032 (2012) [C1]
CitationsScopus - 3Web of Science - 2
2012Koller H, Balogh ZJ, 'Single training session for first time pelvic C-clamp users: Correct pin placement and frame assembly', Injury: International Journal of the Care of the Injured, 43 436-439 (2012) [C1]
CitationsScopus - 4Web of Science - 4
2012Yoshino O, Quail AW, Oldmeadow CJ, Balogh ZJ, 'The interpretation of intra-abdominal pressures from animal models: The rabbit to human example', Injury: International Journal of the Care of the Injured, 43 169-173 (2012) [C1]
CitationsScopus - 4Web of Science - 2
Co-authorsChristopher Oldmeadow, Tony Quail
2012Curtis KA, Mitchell RJ, Chong SS, Balogh ZJ, Reed DJ, Clark PT, et al., 'Injury trends and mortality in adult patients with major trauma in New South Wales', Medical Journal of Australia, 197 233-237 (2012) [C1]
CitationsScopus - 16Web of Science - 17
2012Gruen RL, Brohi K, Schreiber M, Balogh ZJ, Pitt V, Narayan M, Maier RV, 'Haemorrhage control in severely injured patients', Lancet, 380 1099-1108 (2012) [C1]
CitationsScopus - 51Web of Science - 47
2012Balogh ZJ, Reumann MK, Gruen RL, Mayer-Kuckuk P, Schuetz MA, Harris IA, et al., 'Advances and future directions for management of trauma patients with musculoskeletal injuries', Lancet, 380 1109-1119 (2012) [C1]
CitationsScopus - 18Web of Science - 12
2012Puchwein P, Enninghorst N, Sisak K, Ortner T, Schildhauer TA, Balogh ZJ, Pichler W, 'Percutaneous fixation of acetabular fractures: Computer-assisted determination of safe zones, angles and lengths for screw insertion', Archives of Orthopaedic and Trauma Surgery, 132 805-811 (2012) [C1]
CitationsScopus - 8Web of Science - 7
2012Sisak K, Soeyland K, McLeod MG, Jansen M, Enninghorst N, Martin A, Balogh ZJ, 'Massive transfusion in trauma: Blood product ratios should be measured at 6 hours', ANZ Journal of Surgery, 82 161-167 (2012) [C1]
CitationsScopus - 7Web of Science - 7
2012Easton RM, Sisak K, Balogh ZJ, 'Time to computed tomography scanning for major trauma patients: The Australian reality', ANZ Journal of Surgery, 82 644-647 (2012) [C1]
CitationsScopus - 3Web of Science - 3
2012Alrahbi R, Easton RM, Bendinelli C, Enninghorst N, Sisak K, Balogh ZJ, 'Intercostal catheter insertion: Are we really doing well?', ANZ Journal of Surgery, 82 392-394 (2012) [C1]
CitationsScopus - 7Web of Science - 6
2012Bendinelli C, Martin A, Nebauer SD, Balogh ZJ, 'Strangulated intercostal liver herniation subsequent to blunt trauma. First report with review of the world literature', World Journal of Emergency Surgery, 7 23 (2012) [C3]
CitationsScopus - 3Web of Science - 3
2012Pape HC, Balogh ZJ, 'Physician involvement in the care of multiply injured patients: The role of guidelines and subspecialties', European Journal of Trauma and Emergency Surgery, 38 209-210 (2012) [C3]
2012Hofman M, Sellei R, Peralta R, Balogh ZJ, Wong TH, Evans JA, et al., 'Trauma systems: Models of prehospital and inhospital care', European Journal of Trauma and Emergency Surgery, 38 253-260 (2012) [C1]
CitationsScopus - 2Web of Science - 3
2012Livingston D, Gilani R, Balogh Z, Burlew CC, Thorson CM, 'Operating room or angiography suite for hemodynamically unstable pelvic fractures? DISCUSSION', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 72 371-372 (2012) [C3]
Author URL
CitationsWeb of Science - 1
2012Barquist E, Lucas CE, Cohen MJ, Balogh ZJ, Wohlauer MV, 'Acute kidney injury and posttrauma multiple organ failure: The canary in the coal mine DISCUSSION', JOURNAL OF TRAUMA AND ACUTE CARE SURGERY, 72 379-380 (2012) [C3]
Author URL
CitationsWeb of Science - 1
2012Arnold TDW, Balogh ZJ, 'Re: Bland-Altman plot agreement: It is time to stop the stab', Journal of Trauma and Acute Care Surgery, 72 1452-1453 (2012) [C3]
2012Easton RM, Bendinelli C, Sisak K, Enninghorst N, Balogh ZJ, 'Prehospital nausea and vomiting after trauma: Prevalence, risk factors, and development of a predictive scoring system', Journal of Trauma and Acute Care Surgery, 72 1249-1253 (2012) [C1]
CitationsScopus - 1Web of Science - 1
2011Balogh ZJ, Pape HC, 'The challenges and advances of polytrauma care in 2012', European Journal of Trauma and Emergency Surgery, 37 537-538 (2011) [C3]
2011Sisak K, Dewar D, Butcher N, King K, Evans J, Miller M, et al., 'The treatment of traumatic shock: Recent advances and unresolved questions', European Journal of Trauma and Emergency Surgery, 37 567-575 (2011) [C1]
CitationsScopus - 1Web of Science - 1
2011Enninghorst N, Peralta R, Yoshino O, Pfeifer R, Pape HC, Hardy BM, et al., 'Physiological assessment of the polytrauma patient: initial and secondary surgeries', European Journal of Trauma and Emergency Surgery, 37 559-566 (2011) [C1]
CitationsScopus - 1Web of Science - 1
2011Dewar D, Balogh ZJ, 'The epidemiology of multiple-organ failure: A definition controversy', Acta Anaesthesiologica Scandinavica, 55 248-249 (2011) [C3]
DOI10.1111/j.1399-6576.2010.02352.x
CitationsScopus - 3Web of Science - 3
2011Balogh ZJ, Leppaniemi A, 'Patient populations at risk for intra-abdominal hypertension and abdominal compartment syndrome', American Surgeon, 77 S12-S16 (2011) [C1]
CitationsScopus - 5Web of Science - 3
2011Balogh ZJ, Malbrain M, 'Resuscitation in intra-abdominal hypertension and abdominal compartment syndrome', American Surgeon, 77 S31-S33 (2011) [C1]
CitationsScopus - 6Web of Science - 3
2011Balogh ZJ, Martin A, Van Wessem KP, King KL, Mackay P, Havill K, 'Mission to eliminate postinjury abdominal compartment syndrome', Archives of Surgery, 146 938-943 (2011) [C1]
DOI10.1001/archsurg.2011.73
CitationsScopus - 18Web of Science - 13
2011Harrigan PW, Balogh ZJ, 'Quality trauma research and major trauma registries', Injury, 42 38-39 (2011) [C3]
DOI10.1016/j.injury.2010.11.034
CitationsScopus - 1Web of Science - 1
2011Cohen MJ, Lottenberg L, Cryer HG, Balogh Z, Moore EE, Kaplan LJ, Cotton BA, 'Rapid Thrombelastography Delivers Real-Time Results That Predict Transfusion Within 1 Hour of Admission DISCUSSION', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 71 414-417 (2011) [C3]
Author URL
CitationsWeb of Science - 24
2011Arnold TDW, Miller MK, Van Wessem KP, Evans JA, Balogh ZJ, 'Base deficit from the first peripheral venous sample: A surrogate for arterial base deficit in the trauma bay', Journal of Trauma - Injury, Infection and Critical Care, 71 793-797 (2011) [C1]
CitationsScopus - 9Web of Science - 7
2011Balogh ZJ, 'Editorial comment', Journal of Trauma - Injury, Infection and Critical Care, 71 590 (2011) [C3]
DOI10.1097/TA.0b013e318224cd62
2011Enninghorst N, McDougall D, Hunt JJ, Balogh ZJ, 'Open tibia fractures: Timely debridement leaves injury severity as the only determinant of poor outcome', Journal of Trauma-Injury Infection and Critical Care, 70 352-356 (2011) [C1]
DOI10.1097/ta.0b013e31820b4285
CitationsScopus - 9Web of Science - 7
2011Bhandari M, Guyatt G, Jeray K, Balogh ZJ, King KL, Flow Investigators, 'Fluid lavage of open wounds (FLOW): A multicenter, blinded, factorial pilot trial comparing alternative irrigating solutions and pressures in patients with open fractures', Journal of Trauma-Injury Infection and Critical Care, 71 596-606 (2011) [C1]
DOI10.1097/ta.0b013e3181f6f2e8
CitationsScopus - 13Web of Science - 9
2011Balogh ZJ, 'Traumatic shock resuscitation with a 1:1 plasma to packed red blood cell ratio: Is it to please ourselves or the injured?', Critical Care Medicine, 39 1597-1598 (2011) [C3]
DOI10.1097/ccm.0b013e3182148a6a
2011Crash-2 Collaborators, Balogh ZJ, 'The importance of early treatment with tranexamic acid in bleeding trauma patients: An exploratory analysis of the CRASH-2 randomised controlled trial', The Lancet, 377 1096.e2-1101.e2 (2011) [C1]
DOI10.1016/S0140-6736(11)60278-X
CitationsScopus - 238Web of Science - 190
2011Nicholas B, Toth L, Van Wessem K, Evans J, Enninghorst N, Balogh ZJ, 'Borderline femur fracture patients: Early total care or damage control orthopaedics?', ANZ Journal of Surgery, 81 148-153 (2011) [C1]
DOI10.1111/j.1445-2197.2010.05582.x
CitationsScopus - 7Web of Science - 6
2011Fick AEA, Raychaudhuri P, Bear J, Roy G, Balogh ZJ, Kumar R, 'Factors predicting the need for splenectomy in children with blunt splenic trauma', ANZ Journal of Surgery, 81 717-719 (2011) [C1]
DOI10.1111/j.1445-2197.2010.05591.x
CitationsScopus - 2Web of Science - 1
2011Balogh ZJ, 'Solutions for complex upper extremity trauma', ANZ Journal of Surgery, 81 567-568 (2011) [C3]
2011Dewar D, Butcher NE, King KL, Balogh ZJ, 'Post injury multiple organ failure', Trauma, 13 81-91 (2011) [C1]
DOI10.1177/1460408610386657
CitationsScopus - 3
2010De Waele JJ, Cheatham ML, Balogh ZJ, Bjorck M, D'Amours S, De Keulenaer B, et al., 'Intra-abdominal pressure measurement using a U-Tube technique: Caveat emptor', Annals of Surgery, 252 890-891 (2010) [C3]
DOI10.1097/SLA.0b013e3181fded35
CitationsScopus - 1Web of Science - 1
2010Balogh ZJ, Martin AB, 'Prospective cohorts and risk adjusted outcomes for trauma', Injury-International Journal of the Care of the Injured, 41S 24-26 (2010) [C2]
DOI10.1016/j.injury.2010.03.034
CitationsScopus - 2Web of Science - 2
2010Balogh ZJ, Wiles CE, Mullins R, Bosse MJ, 'Skeletal Traction Versus External Fixation in the Initial Temporization of Femoral Shaft Fractures in Severely Injured Patients DISCUSSION', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 68 638-639 (2010) [C3]
Author URL
2010Hoyt DB, Balogh ZJ, Kozar RA, Cook A, 'Acute Definitive Internal Fixation of Pelvic Ring Fractures in Polytrauma Patients: A Feasible Option DISCUSSION', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 68 939-941 (2010) [C3]
Author URL
2010Coimbra R, Billiar TR, Balogh Z, Poggetti RS, Huynh TT, 'Reducing Leukocyte Trafficking Preserves Hepatic Function After Sepsis DISCUSSION', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 69 366-367 (2010) [C3]
Author URL
2010Balogh ZJ, 'Discussion', Journal of Trauma, 68 638-640 (2010) [C3]
DOI10.1097/TA.0b013e3181d27b48
2010Balogh ZJ, 'Editorial comment', Journal of Trauma - Injury, Infection and Critical Care, 68 638-640 (2010) [C3]
DOI10.1097/TA.0b013e3181cef471
2010Enninghorst N, Toth L, King KL, McDougall D, Mackenzie S, Balogh ZJ, 'Acute definitive internal fixation of pelvic ring fractures in polytrauma patients: A feasible option', Journal of Trauma - Injury, Infection and Critical Care, 68 935-939 (2010) [C1]
DOI10.1097/TA.0b013e3181d27b48
CitationsScopus - 21Web of Science - 18
2010Toth L, Balogh ZJ, 'Isolated unilateral sacroiliac dislocation without anterior pelvic ring disruption', Journal of Trauma-Injury Infection and Critical Care, 68 E83-E86 (2010) [C3]
DOI10.1097/TA.0b013e3181cf7ff1
2010Balogh ZJ, 'Skeletal traction versus external fixation in the initial temporization of femoral shaft fractures in severely injured patients. Editorial Comment', Journal of Trauma-Injury Infection and Critical Care, 68 639-640 (2010) [C3]
2010Balogh ZJ, Butcher N, 'Compartment syndromes from head to toe', Critical Care Medicine, 38 S445-S451 (2010) [C1]
DOI10.1097/CCM.0b013e3181ec5d09
CitationsScopus - 15Web of Science - 8
2010Shakur H, Roberts I, Bautista R, Caballero J, Coats T, Dewan Y, et al., 'Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial', LANCET, 376 23-32 (2010) [C1]
DOI10.1016/S0140-6736(10)60835-5Author URL
CitationsScopus - 505Web of Science - 453
2010Balogh ZJ, Evans JA, 'Epidemiology of trauma deaths: Volume, methodology, and comparability-Reply to Letter', World Journal of Surgery, 34 1722-1723 (2010) [C3]
DOI10.1007/s00268-010-0539-8
2010Balogh ZJ, Evans JA, 'Epidemiology of trauma deaths: Location, location, location! Reply', World Journal of Surgery, 34 1722-1723 (2010) [C3]
2010Evans JA, Van Wessem KJP, McDougall D, Lee KA, Lyons TJ, Balogh ZJ, 'Epidemiology of traumatic deaths: Comprehensive population-based assessment', World Journal of Surgery, 34 158-163 (2010) [C1]
DOI10.1007/s00268-009-0266-1
CitationsScopus - 89Web of Science - 83
2010Balogh ZJ, 'Traumatology in Australia: Provision of clinical care and trauma system development', ANZ Journal of Surgery, 80 119-121 (2010) [C3]
DOI10.1111/j.1445-2197.2010.05221.x
CitationsScopus - 5Web of Science - 4
2009De Waele JJ, Cheatham ML, Malbrain MLNG, Kirkpatrick AW, Sugrue M, Balogh ZJ, et al., 'Recommendations for research from the international conference of experts on intra-abdominal hypertension and abdominal compartment syndrome', Acta Clinica Belgica, 64 203-209 (2009) [C1]
CitationsScopus - 24Web of Science - 17
2009Cheatham M, De Waele J, Kirkpatrick A, Sugrue M, Malbrain MLN, Ivatury RR, et al., 'Criteria for a diagnosis of abdominal compartment syndrome', Canadian Journal of Surgery, 52 315-316 (2009) [C3]
CitationsScopus - 7Web of Science - 6
2009Dewar D, Moore FA, Moore EE, Balogh ZJ, 'Postinjury multiple organ failure', Injury, 40 912-918 (2009) [C1]
DOI10.1016/j.injury.2009.05.024
CitationsScopus - 96Web of Science - 87
2009Tan SLE, Balogh ZJ, 'Indications and limitations of locked plating', Injury, 40 683-691 (2009) [C1]
DOI10.1016/j.injury.2009.01.003
CitationsScopus - 45Web of Science - 36
2009Butcher N, Balogh ZJ, 'The definition of polytrauma: The need for international consensus', Injury - International Journal of the Care of the Injured, 40S4 S12-S22 (2009) [C1]
DOI10.1016/j.injury.2009.10.032
CitationsScopus - 38Web of Science - 31
2009Sekine K, Holcomb JB, Moore FA, Duchesne J, Schreiber M, Hawkins ML, et al., 'Predefined Massive Transfusion Protocols are Associated With a Reduction in Organ Failure and Postinjury Complications DISCUSSION', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 66 48-49 (2009) [C3]
Author URL
CitationsWeb of Science - 18
2009Croce MA, Livingston DH, Duane TM, Asensio JA, McQuay N, Balogh ZJ, Dabbs DN, 'Major Hepatic Necrosis: A Common Complication After Angioembolization for Treatment of High-Grade Liver Injuries Discussion', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 66 627-629 (2009) [C3]
Author URL
CitationsWeb of Science - 2
2009Sekine K, Holcomb JB, Moore FA, Duchesne J, Schreiber M, Hawkins ML, et al., 'Discussion', Journal of Trauma - Injury, Infection and Critical Care, 66 48-49 (2009) [C3]
DOI10.1097/TA.0b013e31819313bb
2009Croce MA, Livingston DH, Duane TM, Asensio JA, McQuay Jr N, Balogh ZJ, Dabbs DN, 'Discussion', Journal of Trauma - Injury, Infection and Critical Care, 66 627-629 (2009) [C3]
DOI10.1097/TA.0b013e31819919f2
2009Balogh ZJ, Leppaniemi A, 'The neglected (abdominal) compartment: What is new at the beginning of the 21st century?', World Journal of Surgery, 33 1109 (2009) [C3]
DOI10.1007/s00268-009-0001-y
CitationsScopus - 5Web of Science - 3
2009Balogh ZJ, Van Wessem K, Yoshino O, Moore FA, 'Postinjury abdominal compartment syndrome: Are we winning the battle?', World Journal of Surgery, 33 1134-1141 (2009) [C1]
DOI10.1007/s00268-009-0002-x
CitationsScopus - 26Web of Science - 22
2009Dewar D, Mackay P, Balogh ZJ, 'Epidemiology of post-injury multiple organ failure in an Australian trauma system', ANZ Journal of Surgery, 79 431-436 (2009) [C1]
DOI10.1111/j.1445-2197.2009.04968.x
CitationsScopus - 7Web of Science - 6
2008Lameire N, Balogh Z, Lumb P, 'Editorial introductions', Current Opinion in Critical Care, 14 (2008) [C3]
2008Balogh ZJ, 'Section editor', Current Opinion in Critical Care, 14 (2008) [C2]
2008Bendinelli C, Balogh ZJ, 'Postinjury thromboprophylaxis', Current Opinion in Critical Care, 14 673-678 (2008) [C1]
DOI10.1097/mcc.0b013e3283196538
CitationsScopus - 7Web of Science - 4
2008Sugrue M, Balogh ZJ, Lynch J, Bardsley J, Sisson G, Weigelt J, 'Guidelines for the management of haemodynamically stable patients with stab wounds [Letter]', ANZ Journal of Surgery, 78 106-107 (2008) [C3]
DOI10.1111/j.1445-2197.2007.04380.x
2008Sugrue M, Balogh ZJ, Lynch J, Bardsley J, Sisson G, Weigelt J, 'Re: Guidelines for the management of haemodynamically stable patients with stab wounds to the anterior abdomen [Letter]', ANZ Journal of Surgery, 78 111 (2008) [C3]
DOI10.1111/j.1445-2197.2007.04380.x
2008Balogh ZJ, 'Australian trauma care: Time for change', ANZ Journal of Surgery, 78 935-936 (2008) [C3]
CitationsScopus - 3Web of Science - 3
2008Balogh ZJ, Bendinelli C, Pollitt T, Kozar RA, Moore FA, 'Postinjury primary abdominal compartment syndrome', European Journal of Trauma and Emergency Surgery, 34 369-377 (2008) [C1]
DOI10.1007/s00068-008-8106-9
CitationsScopus - 2Web of Science - 2
2008Cameron P, Phillips L, Balogh Z, Joseph A, Pearce A, Parr M, Jankelowitz G, 'The use of recombinant activated factor VII in trauma patients: Experience from the Australian and New Zealand haemostasis registry (vol 38, pg 1030, 2007)', INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 39 138-139 (2008) [C3]
DOI10.1016/j.injury.2007.09.006Author URL
CitationsWeb of Science - 1
2008Collins JP, Civil ID, Sugrue M, Balogh ZJ, Chehade MJ, 'Surgical education and training in Australia and New Zealand', World Journal of Surgery, 32 2138-2144 (2008) [C1]
DOI10.1007/s00268-008-9680-z
CitationsScopus - 17Web of Science - 14
2008Verbeek D, Sugrue M, Balogh ZJ, Cass D, Civil I, Harris I, et al., 'Acute management of hemodynamically unstable pelvic trauma patients: Time for a change? Multicenter review of recent practice', World Journal of Surgery, 32 1874-1882 (2008) [C1]
DOI10.1007/s00268-008-9591-z
CitationsScopus - 48Web of Science - 38
2007Cheatham ML, Malbrain M, Kirkpatrick A, Sugrue M, Parr M, Dewaele J, et al., 'Results from the International Conference of Experts on Intra-Abdominal Hypertension and Abdominal Compartment Syndrome. II. Recommendations', Intensive Care Medicine, 33 951-962 (2007) [C1]
DOI10.1007/s00134-007-0592-4
CitationsScopus - 414Web of Science - 372
2007Moore F, McKinley B, Balogh Z, 'The problem: Coagulopathy of posttraumatic massive transfusion (PMT)', INFLAMMATION RESEARCH, 56 S187-S188 (2007)
Author URL
2007Bodnar Z, Sipka S, Szentkereszty Z, Hajdu Z, Balogh Z, 'The gold standard technique for intra-abdominal pressure monitoring in septic patients: Continuous intra-abdominal pressure monitoring (CIAPM)', INFLAMMATION RESEARCH, 56 S213-S214 (2007)
Author URL
2007Balogh Z, Bodnar Z, Moore F, 'Abdominal compartment syndrome complicating infection', INFLAMMATION RESEARCH, 56 S240-S240 (2007)
Author URL
2007Sugrue M, Balogh ZJ, Lynch J, Bardsley J, Sisson G, Weigelt J, 'Guidelines for the management of haemodynamically stable patients with stab wounds to the anterior abdomen', ANZ Journal of Surgery, 77 614-620 (2007) [C1]
DOI10.1111/j.1445-2197.2007.04173.x
CitationsScopus - 14Web of Science - 13
2007Balogh Z, 'Continuous intra-abdominal pressure monitoring', ACTA CLINICA BELGICA, 62 234-234 (2007)
Author URL
2007Mackay P, van Wessem K, Balogh Z, 'Post-injury abdominal compartment syndrome: Is it still a problem?', ACTA CLINICA BELGICA, 62 293-293 (2007)
Author URL
2007Balogh ZJ, De Waele JJ, Malbrain M, 'Continuous intra-abdominal pressure monitoring', Acta Clinica Belgica, 62 26-32 (2007) [C1]
CitationsScopus - 38Web of Science - 22
2007Cameron P, Phillips L, Balogh ZJ, Joseph A, Pearce A, Parr M, Jankelowitz G, 'The use of recombinant activated factor VII in trauma patients: Experience from the Australian and New Zealand haemostasis registry', Injury, 38 1030-1038 (2007) [C1]
DOI10.1016/j.injury.2007.05.003
CitationsScopus - 18Web of Science - 18
2007Balogh ZJ, Moore FA, Moore EE, Biffl WL, 'Secondary abdominal compartment syndrome: A potential threat for all trauma clinicians', Injury - International Journal of the Care of the Injured, 38 272-279 (2007) [C1]
DOI10.1016/j.injury.2006.02.026
CitationsScopus - 34Web of Science - 26
2007Peitzman AB, Balogh Z, Hauser C, 'The epidemiology of pelvic ring fractures: A population-based study - Discussion', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 63 1072-1073 (2007)
Author URL
CitationsWeb of Science - 2
2007Balogh ZJ, Evans JA, Seah PW, King KL, 'Supraclavicular cyanosis: Clinical sign of acute blunt traumatic pericardial tamponade', Journal of Trauma - Injury, Infection and Critical Care, 63 245 (2007) [C3]
2007Balogh Z, King KL, Mackay P, McDougall D, Mackenzie S, Evans JA, et al., 'The epidemiology of pelvic ring fractures: A population-based study', Journal of Trauma-Injury Infection and Critical Care, 63 1066-1073 (2007) [C1]
DOI10.1097/TA.0b013e3181589fa4
CitationsScopus - 45Web of Science - 35
2007Balogh ZJ, De Waele JJ, Kirkpatrick A, Cheatham M, D'Amours S, Malbrain M, 'Intra-abdominal pressure measurement and abdominal compartment syndrome: The opinion of the World Society of the Abdominal Compartment Syndrome (Letter)', Critical Care Medicine, 35 677-678 (2007) [C3]
CitationsScopus - 3Web of Science - 2
2006Malbrain MLNG, Cheatham ML, Kirkpatrick A, Sugrue M, Parr M, De Waele J, et al., 'Results from the International Conference of Experts on Intra-abdominal Hypertension and Abdominal Compartment Syndrome. I. Definitions', Intensive Care Medicine, 32 1722-1732 (2006) [C1]
DOI10.1007/s00134-006-0349-5
CitationsScopus - 553Web of Science - 514
2006Balogh Z, Kirkpatrick AW, Ball CG, Zygun D, 'The secondary abdominal compartment syndrome: Iatrogenic or unavoidable?', JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 203 406-407 (2006)
DOI10.1016/j.jamcollsurg.2006.06.007Author URL
CitationsScopus - 3
2006Kirkpatrick AW, Balogh ZJ, Ball CG, Ahmed N, Chun R, McBeth P, et al., 'The secondary abdominal compartment syndrome: Iatrogenic or unavoidable?', Journal of the American College of Surgeons, 202 668-679 (2006) [C1]
DOI10.1016/j.jamcollsurg.2005.11.020
CitationsScopus - 82Web of Science - 72
2006Ollerton JE, Sugrue M, Balogh Z, D'Amours SK, Giles A, Wyllie P, 'Prospective study to evaluate the influence of FAST on trauma patient management', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 60 785-791 (2006)
DOI10.1097/01.ta.0000214583.21492.e8Author URL
CitationsScopus - 53Web of Science - 40
2005Balogh Z, Moore FA, 'Intra-abdominal hypertension: Not just a surgical critical care curiosity', CRITICAL CARE MEDICINE, 33 447-449 (2005)
DOI10.1097/01.CCM.0000153411.35214.91Author URL
CitationsScopus - 8Web of Science - 8
2005Balogh Z, Caldwell E, Heetveld M, D'Amours S, Schlaphoff G, Harris I, Sugrue M, 'Institutional practice guidelines on management of pelvic fracture-related hemodynamic instability: Do they make a difference?', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 58 778-782 (2005)
DOI10.1097/01.TA.0000158251.40760.B2Author URL
CitationsScopus - 77Web of Science - 69
2004Cribari C, Balogh Z, Moore F, Kuhls D, 'Continuous intra-abdominal pressure measurement technique - Discussion', AMERICAN JOURNAL OF SURGERY, 188 683-684 (2004)
Author URL
2004Balogh Z, Moore FA, McKinley BA, 'Supranormal trauma resuscitation and abdominal compartment syndrome - In reply', ARCHIVES OF SURGERY, 139 226-227 (2004)
DOI10.1001/archsurg.139.2.226Author URL
CitationsWeb of Science - 2
2004Heetveld MJ, Harris I, Schlaphoff G, Balogh Z, D'Amours SK, Sugrue M, 'Hemodynamically unstable pelvic fractures: Recent care and new guidelines', WORLD JOURNAL OF SURGERY, 28 904-909 (2004)
DOI10.1007/s00268-004-7357-9Author URL
CitationsScopus - 49Web of Science - 45
2004Balogh Z, Moore FA, 'Recent advances in the characterisation of post-injury abdominal compartment syndrome', International Journal of Intensive Care, 11 30-42 (2004)

Abdominal compartment syndrome (ACS) is defined as intra-abdominal pressure (IAP) higher than 25 mmHg with organ dysfunction (cardiac, respiratory, renal) if the organ dysfunction... [more]

Abdominal compartment syndrome (ACS) is defined as intra-abdominal pressure (IAP) higher than 25 mmHg with organ dysfunction (cardiac, respiratory, renal) if the organ dysfunction improves after abdominal decompression. ACS is the imbalance between abdominal volume and abdominal content where the abdominal volume is defined by the least tensile component of the abdominal compartment (i.e. the fascia). Increasing abdominal content or decreasing volume causes ACS, which impairs abdominal organ perfusion, as in other well recognised 'compartment' conditions of increased intra-cranial pressure, pericardial tamponade, tension pneumothorax or extremity compartment syndromes.

2004Sugrue M, Balogh Z, Malbrain M, 'Intra-abdominal hypertension and renal failure', ANZ JOURNAL OF SURGERY, 74 78-78 (2004)
DOI10.1046/j.1445-1433.2003.02896.xAuthor URL
CitationsScopus - 13Web of Science - 11
2003Balogh ZJ, 'Supra-normal trauma resuscitation causes more cases of abdominal compartment syndrome', Archives of Surgery, 637-642 (2003) [C1]
CitationsScopus - 282Web of Science - 233
2003Balogh Z, Voros E, Suveges G, Simonka JA, 'Stent graft treatment of an external iliac artery injury associated with pelvic fracture - A case report', JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 85A 919-922 (2003)
Author URL
CitationsScopus - 1Web of Science - 1
2003Reilly P, Balogh Z, Shackford SR, Wang D, 'Both primary and secondary abdominal compartment syndrome can be predicted early and are harbingers of multiple organ failure - Discussion', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 54 859-861 (2003)
Author URL
CitationsWeb of Science - 30
2003Miller CC, Balogh Z, McKinley BA, Moore FA, 'Letter to the Editor - The Author's Reply', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 55 1004-1005 (2003)
Author URL
2003Balogh ZJ, Varga E, Tomka J, Suveges G, Toth L, Simonka JA, 'The new injury severity score is a better predictor of extended hospitalization and intensive care unit admission than the injury severity score in patients with multiple orthopaedic injuries', JOURNAL OF ORTHOPAEDIC TRAUMA, 17 508-512 (2003)
DOI10.1097/00005131-200308000-00006Author URL
CitationsScopus - 29Web of Science - 24
2003Balogh Z, McKinley BA, Cox CS, Allen SJ, Cocanour CS, Kozar RA, et al., 'Abdominal compartment syndrome: The cause or effect of postinjury multiple organ failure', SHOCK, 20 483-492 (2003)
DOI10.1097/01.shk.0000093346.68755.43Author URL
CitationsScopus - 117Web of Science - 105
2003Bowling WM, Miller CC, Balogh Z, McKinley BA, Moore FA, 'Letter to the editor [1] (multiple letters)', Journal of Trauma - Injury, Infection and Critical Care, 55 1004-1005 (2003)
DOI10.1097/01.TA.0000094212.36512.78
2002Balogh Z, Wolfard A, Szalay L, Orosz E, Simonka JA, Boros M, 'Dalteparin sodium treatment during resuscitation inhibits hemorrhagic shock-induced leukocyte rolling and adhesion in the mesenteric microcirculation', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 52 1062-1069 (2002)
DOI10.1097/00005373-200206000-00007Author URL
CitationsScopus - 8Web of Science - 7
2002Burch J, Balogh Z, Smith S, 'Secondary abdominal compartment syndrome is an elusive early complication of traumatic shock resuscitation - Discussion', AMERICAN JOURNAL OF SURGERY, 184 543-544 (2002)
Author URL
CitationsWeb of Science - 12
2000Balogh Z, Offner PJ, Moore EE, Biffl WL, 'NISS predicts postinjury multiple organ failure better than the ISS', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 48 624-627 (2000)
DOI10.1097/00005373-200004000-00007Author URL
CitationsScopus - 57Web of Science - 42
2000Osler TM, West A, Hauser CJ, Lewis FR, Balogh Z, 'NISS predicts postinjury multiple organ failure better than the ISS - Discussion', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 48 627-628 (2000)
Author URL
CitationsWeb of Science - 5
1999Wolfard A, Kaszaki J, Szabo C, Balogh Z, Nagy S, Boros M, 'Effects of selective nitric oxide synthase inhibition in hyperdynamic endotoxemia in dogs', EUROPEAN SURGICAL RESEARCH, 31 314-323 (1999)
DOI10.1159/000008708Author URL
CitationsScopus - 8Web of Science - 8
1997Wolfárd A, Kaszaki J, Szabó C, Balogh Z, Nagy S, 'Effects of nitric oxide synthase inhibition on the hemodynamic changes in hyperdynamic endotoxemia.', Acta chirurgica Hungarica, 36 393-394 (1997)

In this study we compared the circulatory effects of the arginine analogue non-specific nitric oxide synthase (NOS) inhibitor N omega-nitro-L-arginine (NNA), and the specific indu... [more]

In this study we compared the circulatory effects of the arginine analogue non-specific nitric oxide synthase (NOS) inhibitor N omega-nitro-L-arginine (NNA), and the specific inducible NOS (iNOS) inhibitor S-methylisothiourea (SMT) and S-(2-aminoethyl)-isothiourea (AEST) in a hyperdynamic endotoxemic dog model. Mean arterial pressure (MAP), cardiac output (CO), and myocardial contractility (MC) were measured. A hyperdynamic circulatory response was elicited with a 2-h infusion of a total dose of 5.3 micrograms/kg E. coli endotoxin (ETX). NOS inhibitory treatment (2 mg/kg) was administrated from the 45th min of endotoxemia. ETX induced a hyperdynamic circulatory response, and a significant myocardial depression. NNA induced a prolonged, SMT a transient increase in MC, both drugs elevated MAP, but decreased CO. AEST significantly prolonged the elevation in CO, but did not affect MAP. Selective inhibition of the iNOS may be a beneficial in sepsis.

CitationsScopus - 1
Show 167 more journal articles

Conference (39 outputs)

YearCitationAltmetricsLink
2015McIlroy DJ, Bigland M, White AE, Hardy BM, Lott N, Smith DW, Balogh ZJ, 'Cell necrosis-independent sustained mitochondrial and nuclear DNA release following trauma surgery', Journal of Trauma and Acute Care Surgery (2015)

Background: Mitochondrial DNA (mtDNA), a potent proinflammatory damage-associated molecular pattern, is released in large titers following trauma. The effect of trauma surgery on ... [more]

Background: Mitochondrial DNA (mtDNA), a potent proinflammatory damage-associated molecular pattern, is released in large titers following trauma. The effect of trauma surgery on mtDNA concentration is unknown. We hypothesized that mtDNA and nuclear DNA (nDNA) levels would increase proportionately with the magnitude of surgery and both would then decrease rapidly. Methods: In this prospective pilot, plasma was sampled from 35 trauma patients requiring orthopedic surgical intervention at six perioperative time points. Healthy control subjects (n = 20)were sampled.DNAwas extracted, and the mtDNA and nDNAwere assessed using quantitative polymerase chain reaction. Markers of cell necrosis were also assayed (creatine kinase, lactate dehydrogenase, and aspartate aminotransferase). Results: The free plasma mtDNA and nDNA levels (ng/mL) were increased in trauma patients compared with healthy controls at all time points (mtDNA: preoperative period, 108 [46-284]; postoperative period, 96 [29-200]; 7 hours postoperatively, 88 [43-178]; 24 hours, 79 [36-172]; 3 days, 136 [65-263]; 5 days, 166 [101-434] [healthy controls, 11 (5-19)]) (nDNA: preoperative period, 52 [25-130]; postoperative period, 100 [35-208]; 7 hours postoperatively, 75 [36-139]; 24 hours postoperatively, 85 [47-133]; 3 days, 79 [48-117]; 5 days, 99 [41-154] [healthy controls, 29 (16-54)]). Elevated DNA levels did not correlate with markers of cellular necrosis. mtDNA was significantly elevated compared with nDNA at preoperative period (p = 0.003), 3 days (p = 0.003), and 5 days (p = 0.0014). Preoperative mtDNA levelswere greater with shorter time from injury to surgery (p = 0.0085). Postoperative mtDNA level negatively correlated with intraoperative crystalloid infusion (p = 0.0017). Major pelvic surgery (vs. minor) was associated with greater mtDNA release 5 days postoperatively (p G 0.05). Conclusion: This pilot of heterogeneous orthopedic trauma patients showed that the release of mtDNA and nDNA is sustained for 5 days following orthopedic trauma surgery. Postoperative, circulating DNA is not associated with markers of tissue necrosis but is associated with surgical invasiveness and is inversely related to intraoperative fluid administration. Sustained elevation of mtDNA levels could be of inflammatory origin and may contribute to postinjury dysfunctional inflammation. Level of Evidence: Prospective study, level III.

DOI10.1097/TA.0000000000000519
CitationsScopus - 1
2015Duchesne JC, Kaplan LJ, Balogh ZJ, Malbrain MLNG, 'Role of permissive hypotension, hypertonic resuscitation and the global increased permeability syndrome in patients with severe haemorrhage: Adjuncts to damage control resuscitation to prevent intra-abdominal hypertension', Anaesthesiology Intensive Therapy (2015)

Secondary intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are closely related to fluid resuscitation. IAH causes major deterioration of the cardiac fun... [more]

Secondary intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are closely related to fluid resuscitation. IAH causes major deterioration of the cardiac function by affecting preload, contractility and afterload. The aim of this review is to discuss the different interactions between IAH, ACS and resuscitation, and to explore a new hypothesis with regard to damage control resuscitation, permissive hypotension and global increased permeability syndrome. The recognition of the association between the development of ACS and resuscitation urged the need for new approach in traumatic shock management. Over a decade after wide spread application of damage control surgery damage control resuscitation was developed. DCR differs from previous resuscitation approaches by attempting an earlier and more aggressive correction of coagulopathy, as well as metabolic derangements like acidosis and hypothermia, often referred to as the 'deadly triad' or the 'bloody vicious cycle'. Permissive hypotension involves keeping the blood pressure low enough to avoid exacerbating uncontrolled haemorrhage while maintaining perfusion to vital end organs. The potential detrimental mechanisms of early, aggressive crystalloid resuscitation have been described. Limitation of fluid intake by using colloids, hypertonic saline (HTS) or hyperoncotic albumin solutions have been associated with favourable effects. HTS allows not only for rapid restoration of circulating intravascular volume with less administered fluid, but also attenuates post-injury oedema at the microcirculatory level and may improve microvascular perfusion. Capillary leak represents the maladaptive, often excessive, and undesirable loss of fluid and electrolytes with or without protein into the interstitium that generates oedema. The global increased permeability syndrome (GIPS) has been articulated in patients with persistent systemic inflammation failing to curtail transcapillary albumin leakage and resulting in increasingly positive net fluid balances. GIPS may represent a third hit after the initial insult and the ischaemia reperfusion injury. Novel markers like the capillary leak index, extravascular lung water and pulmonary permeability index may help the clinician in guiding appropriate fluid management. Capillary leak is an inflammatory condition with diverse triggers that results from a common pathway that includes ischaemia-reperfusion, toxic oxygen metabolite generation, cell wall and enzyme injury leading to a loss of capillary endothelial barrier function. Fluid overload should be avoided in this setting.

DOI10.5603/AIT.a2014.0052
2014Duchesne JC, Kaplan LJ, Balogh ZJ, Malbrain MLNG, 'Role of permissive hypotension, hypertonic resuscitation and the global increased permeability syndrome in patients with severe haemorrhage: Adjuncts to damage control resuscitation to prevent intra-abdominal hypertension', Anaesthesiology Intensive Therapy (2014)

Secondary intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are closely related to fluid resuscitation. IAH causes major deterioration of the cardiac fun... [more]

Secondary intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) are closely related to fluid resuscitation. IAH causes major deterioration of the cardiac function by affecting preload, contractility and afterload. The aim of this review is to discuss the different interactions between IAH, ACS and resuscitation, and to explore a new hypothesis with regard to damage control resuscitation, permissive hypotension and global increased permeability syndrome. The recognition of the association between the development of ACS and resuscitation urged the need for new approach in traumatic shock management. Over a decade after wide spread application of damage control surgery damage control resuscitation was developed. DCR differs from previous resuscitation approaches by attempting an earlier and more aggressive correction of coagulopathy, as well as metabolic derangements like acidosis and hypothermia, often referred to as the 'deadly triad' or the 'bloody vicious cycle'. Permissive hypotension involves keeping the blood pressure low enough to avoid exacerbating uncontrolled haemorrhage while maintaining perfusion to vital end organs. The potential detrimental mechanisms of early, aggressive crystalloid resuscitation have been described. Limitation of fluid intake by using colloids, hypertonic saline (HTS) or hyperoncotic albumin solutions have been associated with favourable effects. HTS allows not only for rapid restoration of circulating intravascular volume with less administered fluid, but also attenuates post-injury oedema at the microcirculatory level and may improve microvascular perfusion. Capillary leak represents the maladaptive, often excessive, and undesirable loss of fluid and electrolytes with or without protein into the interstitium that generates oedema. The global increased permeability syndrome (GIPS) has been articulated in patients with persistent systemic inflammation failing to curtail transcapillary albumin leakage and resulting in increasingly positive net fluid balances. GIPS may represent a third hit after the initial insult and the ischaemia reperfusion injury. Novel markers like the capillary leak index, extravascular lung water and pulmonary permeability index may help the clinician in guiding appropriate fluid management. Capillary leak is an inflammatory condition with diverse triggers that results from a common pathway that includes ischaemia-reperfusion, toxic oxygen metabolite generation, cell wall and enzyme injury leading to a loss of capillary endothelial barrier function. Fluid overload should be avoided in this setting.

DOI10.5603/AIT.a2014.0052
2012Hardy BM, Yoshino O, Quail AW, Balogh ZJ, 'Influence of the timing of internal fixation of femur fractures during shock resuscitation on remote organ damage', ANZ Journal of Surgery, Kuala Lumpur, Malaysia (2012) [E3]
Co-authorsTony Quail
2011Koller H, Uranues S, Balogh ZJ, 'Single training session for first time pelvic C-clamp users: What to expect?', World Journal of Surgery, Yokohama, Japan (2011) [E3]
2011Yoshino O, Matthys R, Balogh ZJ, 'Blunt polytrauma model with femur fracture', World Journal of Surgery, Yokohama, Japan (2011) [E3]
2011Sisak K, Balogh ZJ, Bendinelli C, Enninghorst N, 'Acute transfusion practice during trauma resuscitation: Who, when and why?', ANZ Journal of Surgery, Adelaide, SA (2011) [E3]
2011Enninghorst N, McDougall D, Sisak K, Balogh ZJ, 'The epidemiology of femoral shaft fractures in an inclusive trauma system', ANZ Journal of Surgery, Adelaide, SA (2011) [E3]
2011Easton RM, Bendinelli C, Enninghorst N, Sisak K, Regan D, Balogh ZJ, 'Prehospital nausea and vomiting revisited', ANZ Journal of Surgery, Adelaide, SA (2011) [E3]
2011Chan S, Martin A, Hardy BM, Gallagher A, Sokolowsky A, Balogh ZJ, 'Temperature change in the helicopter retrieval of trauma patients', ANZ Journal of Surgery, Adelaide, SA (2011) [E3]
2011Easton RM, Bendinelli C, Powell A, Enninghorst N, Sisak K, Binks D, Balogh ZJ, 'Recall of pain after acute trauma', ANZ Journal of Surgery, Adelaide, SA (2011) [E3]
2011Alrahbri R, Bendinelli C, Sisak K, Enninghorst N, Balogh ZJ, 'Intercostal catheter insertion: Are we really doing well?', ANZ Journal of Surgery, Adelaide, SA (2011) [E3]
2010De Waele J, Balogh Z, Bjorck M, Cheatham M, Ivatury R, Kirkpatrick A, Malbrain M, 'AWARENESS OF AND ATTITUDES REGARDING INTRA-ABDOMINAL HYPERTENSION AND ABDOMINAL COMPARTMENT SYNDROME: RESULTS FROM AN INTERNATIONAL SURVEY (WSACS STUDY 003)', INTENSIVE CARE MEDICINE, Barcelona, SPAIN (2010) [E3]
Author URL
2010Balogh ZJ, De Malmanche T, Estens JL, 'Immune monitoring in polytrauma: Report of a pilot study', ANZ Journal of Surgery, Perth, WA (2010) [E3]
2009Tjeuw MH-Y, Oakley SP, Balogh ZJ, Major GA, 'Bisphosphonate use increases risk of transverse minimal trauma fracture of femoral diaphysis', Arthritis & rheumatism, Philadelphia, Pennsylvania (2009) [E3]
2009Balogh ZJ, 'Prediction models for Abdominal Compartment Syndrome', Acta Clinica Belgica, Dublin, Ireland (2009) [E3]
2009Yoshino O, Quail AW, Balogh ZJ, 'Secondary intra-abdominal hypertension: New animal model', Acta Clinica Belgica, Dublin, Ireland (2009) [E3]
Co-authorsTony Quail
2009Van Wessem K, King KL, Mackay P, Havill K, Balogh ZJ, 'The effect of retroperitoneal haematoma on intra-abdominal hypertension', Acta Clinica Belgica, Dublin, Ireland (2009) [E3]
2009Balogh ZJ, Martin A, King KL, Van Wessem K, Mackay P, Havill K, 'The clinical significance of postinjury intra-abdominal hypertension', Acta Clinica Belgica, Dublin, Ireland (2009) [E3]
2009Yoshino O, Quail AW, Balogh ZJ, 'Clinically Relevant Model for Secondary Abdominal Compartment Syndrome', The American Society for the Surgery of Trauma 2009 Poster Abstracts, Pittsburgh, PA (2009) [E3]
Co-authorsTony Quail
2009Tjeuw M, Oakley S, Van Der Kallen JA, Tan E, Balogh ZJ, Major GA, 'Transverse sub-trochanteric minimal trauma fractures: A relationship to bisphosphonate therapy', Internal Medicine Journal, Wellington, NZ (2009) [E3]
2009Van Der Kallen JA, McGrath B, Balogh ZJ, Major GA, 'Bisphosphonates reduce refracture rates in patients after neck of femure fractures', Internal medicine journal, Wellington, NZ (2009) [E3]
2007Mackay P, King KE, Mackenzie S, McDougall D, Evans JA, Balogh ZJ, 'The epidemiology of pelvic fractures: The whole picture', ANZ Journal of Surgery, Whyalla, SA (2007) [E3]
2007Van Wessem KJP, Mackay PJ, Balogh ZJ, 'Prospective validation of the independent predictors for postinjury intra-abdominal hypertension', ANZ Journal of Surgery, Whyalla, SA (2007) [E3]
2007Dewar DC, Balogh ZJ, Mackay P, 'Post injury multiple organ failure: The Australian context', ANZ Journal of Surgery, Whyalla, SA (2007) [E3]
2005McKinley BA, Balogh Z, Kozar RA, Valdivia A, Moore FA, 'GI tonometry is a monitor of onset of ACS', SHOCK, Marco Isl, FL (2005)
Author URL
2005Sugrue M, Balogh ZJ, Jamesraj J, Jones F, D'Amours S, 'Continuous abdominal perfusion pressure measurement: New technique', ANZ Journal of Surgery, Noosa, Queensland (2005) [E3]
2005Balogh ZJ, Jones F, D'Amours S, Parr M, Sugrue M, 'Continuous intra-abdominal pressure measurement technique: A new gold standard', ANZ Journal of Surgery, Noosa, Queensland (2005) [E3]
2005Peters K, Jones F, Sugrue M, Bauman A, Parr M, Balogh ZJ, 'How reliable is intra-abdominal pressure measurement in Intensive Care?', ANZ Journal of Surgery, Noosa, Queensland (2005) [E3]
2005Jones F, Peters K, Sugrue M, Balogh ZJ, Frost S, Hillman K, 'Simplified intra-abdominal pressure measurement: Is it valid?', ANZ Journal of Surgery, Noosa, Queensland (2005) [E3]
2004Balogh Z, Jones F, D'Amours S, Parr M, Sugrue M, 'Continuous intra-abdominal pressure measurement technique', AMERICAN JOURNAL OF SURGERY, Monterey, CA (2004)
DOI10.1016/j.amjsurg.2004.08.052Author URL
CitationsScopus - 107Web of Science - 90
2004Balogh Z, McKinley BA, Moore FA, 'Gastric tonometry is an early independent predictor of abdominal compartment syndrome', SHOCK, Munich, GERMANY (2004)
Author URL
2004Moore FA, Balogh Z, McKinley B, 'Computerized decision support (CDS) for shock resuscitation', SHOCK, Munich, GERMANY (2004)
Author URL
2004Balogh Z, Moore FA, McKinley BA, 'The prediction and management of post-injury primary and secondary compartment syndrome', SHOCK, Munich, GERMANY (2004)
Author URL
2003Balogh Z, McKinley BA, Cocanour CS, Kozar RA, Cox CS, Moore FA, 'Patients with impending, abdominal compartment syndrome do not respond to early volume loading', AMERICAN JOURNAL OF SURGERY, TUCSON, ARIZONA (2003)
DOI10.1016/j.amjsurg.2003.09.002Author URL
CitationsScopus - 50Web of Science - 44
2003Balogh Z, McKinley BA, Holcomb JB, Miller CC, Cocanour CS, Kozar RA, et al., 'Both primary and secondary abdominal compartment syndrome can be predicted early and are harbingers of multiple organ failure', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, ORLANDO, FLORIDA (2003)
DOI10.1097/01.TA.0000070166.29649.F3Author URL
CitationsScopus - 256Web of Science - 211
2003Suliburk JW, Ware DN, Balogh Z, McKinley BA, Cocanour CS, Kozar RA, Moore FA, 'Vacuum-assisted wound closure achieves early fascial closure of open abdomens after severe trauma', JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, SNOWBIRD, UTAH (2003)
DOI10.1097/01.TA.0000100218.03754.6AAuthor URL
CitationsScopus - 113Web of Science - 104
2002Balogh Z, McKinley BA, Cocanour CS, Kozar RA, Holcomb JB, Ware DN, Moore FA, 'Secondary abdominal compartment syndrome is an elusive early complication of traumatic shock resuscitation', AMERICAN JOURNAL OF SURGERY, CORONADO, CALIFORNIA (2002)
DOI10.1016/S0002-9610(02)01050-4Author URL
CitationsScopus - 132Web of Science - 108
1995Kaszaki J, Wolfard A, Balogh ZJ, Parratt JR, Nagy S, 'The role of nitric oxide in the early hemodynamic changes in hyperdynamic endotoxemia', Shock, Vienna, Austria (1995) [E3]
Show 36 more conferences

Other (4 outputs)

YearCitationAltmetricsLink
2014Balogh ZJ, 'Trauma Surgery - Forward', ( pp.vii-viii). Verlag, Italy: Springer (2014)
2013Curtis KA, Mitchell RJ, Chong SS, Balogh ZJ, Clark PT, D'Amours S, et al., 'Injury trends and mortality in adult patients with major trauma in New South Wales REPLY', ( issue.9 pp.481-481): AUSTRALASIAN MED PUBL CO LTD (2013) [C3]
DOI10.5694/mja12.11623Author URL
CitationsWeb of Science - 1
2013Balogh ZJ, 'Mastering Orthopedic Techniques: Intra-articular Fractures - Forward', ( pp.xiii). New Delhi, India: Jaypee (2013)
2013Balogh ZJ, 'Damian John McMahon, MBBS, FRACS: Trauma surgeon and patient advocate (1958-2012) IN MEMORIAM', ( issue.2 pp.701-702): LIPPINCOTT WILLIAMS & WILKINS (2013) [O1]
DOI10.1097/TA.0b013e31827e22b9Author URL
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Grants and Funding

Summary

Number of grants13
Total funding$1,442,852

Click on a grant title below to expand the full details for that specific grant.


20152 grants / $186,532

HMRI MRSP Infrastructure (15-16) - Traumatology$161,310

Funding body: Hunter Medical Research Institute

Funding bodyHunter Medical Research Institute
Project TeamProfessor Zsolt Balogh
SchemeNSW MRSP Infrastructure Grant
RoleLead
Funding Start2015
Funding Finish2015
GNoG1500827
Type Of FundingOther Public Sector - State
Category2OPS
UONY

John Hunter Hospital Charitable Trust Grant Round 2015$25,222

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Funding body: John Hunter Hospital, Newcastle

Funding bodyJohn Hunter Hospital, Newcastle
Project Team
Schemetrust grant
RoleLead
Funding Start2015
Funding Finish2015
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

20142 grants / $374,658

Evaluation of a tailored online hospital and post-discharge smoking cessation program for orthopaedic trauma surgery patients$364,658

Funding body: NHMRC (National Health & Medical Research Council)

Funding bodyNHMRC (National Health & Medical Research Council)
Project TeamAssociate Professor Billie Bonevski, Professor Zsolt Balogh, Professor Amanda Baker, Professor Ian Harris, Professor John Attia, Conjoint Professor Christopher Doran, Dr Johnson George, Doctor Luke Wolfenden
SchemePartnership Projects
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1300686
Type Of FundingAust Competitive - Commonwealth
Category1CS
UONY

Neurochemical dysfunction following concussion and mild traumatic brain injury in 10-16 year olds $10,000

Funding body: University of Newcastle

Funding bodyUniversity of Newcastle
Project TeamProfessor Carolyn Mountford, Professor Zsolt Balogh, Doctor Saadallah Ramadan
SchemeNear Miss Grant
RoleInvestigator
Funding Start2014
Funding Finish2014
GNoG1301397
Type Of FundingInternal
CategoryINTE
UONY

20132 grants / $98,959

The role of mitochondrial DNA in the post-injury inflammatory response following major trauma$73,959

Funding body: Hunter New England Local Health District

Funding bodyHunter New England Local Health District
Project TeamProfessor Zsolt Balogh, Dr Daniel Mcilroy
SchemeTrauma Education and Research Fund Scholarship
RoleLead
Funding Start2013
Funding Finish2013
GNoG1300217
Type Of FundingOther Public Sector - State
Category2OPS
UONY

Australian Orthopaedic Association Research Foundation Grant$25,000

Funding body: AOA Australian Orthopaedic Association

Funding bodyAOA Australian Orthopaedic Association
Project Team
SchemeResearch Grant
RoleLead
Funding Start2013
Funding Finish2013
GNo
Type Of FundingNot Known
CategoryUNKN
UONY

20122 grants / $46,368

Peri-operative immune-monitoring post trauma$37,500

Funding body: AOA Australian Orthopaedic Association

Funding bodyAOA Australian Orthopaedic Association
Project TeamProfessor Zsolt Balogh
SchemeResearch Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1101115
Type Of FundingGrant - Aust Non Government
Category3AFG
UONY

Tissue oxygenation saturation (StO2) changes during intramedullary nailing of lower limb fractures$8,868

Funding body: AOTrauma Asia Pacific

Funding bodyAOTrauma Asia Pacific
Project TeamProfessor Zsolt Balogh
SchemeResearch Grant
RoleLead
Funding Start2012
Funding Finish2012
GNoG1101134
Type Of FundingInternational - Competitive
Category3IFA
UONY

20112 grants / $38,393

The immunological impact of orthopaedic trauma operative procedures$30,000

Funding body: John Hunter Hospital Charitable Trust Fund

Funding bodyJohn Hunter Hospital Charitable Trust Fund
Project Team
SchemeResearch Grant
RoleLead
Funding Start2011
Funding Finish2013
GNo
Type Of FundingOther Public Sector - Commonwealth
Category2OPC
UONY

Australian Pelvic & Acetabular Fracture Database$8,393

Funding body: AOTrauma Asia Pacific

Funding bodyAOTrauma Asia Pacific
Project TeamProfessor Zsolt Balogh
SchemeResearch Grant
RoleLead
Funding Start2011
Funding Finish2011
GNoG1001023
Type Of FundingInternational - Competitive
Category3IFA
UONY

20101 grants / $600,000

Education and Research$600,000

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Funding body: Xstrata Coal Australia Pty Ltd

Funding bodyXstrata Coal Australia Pty Ltd
Project Team
SchemeEducational Research Grant
RoleLead
Funding Start2010
Funding Finish2012
GNo
Type Of FundingOther Public Sector - Local
Category2OPL
UONY

20081 grants / $60,942

The effects of resuscitation fluids on intra-abdominal pressure$60,942

Funding body: Hunter New England Area Health Service

Funding bodyHunter New England Area Health Service
Project TeamProfessor Zsolt Balogh
SchemeTrauma Education and Research Fund Scholarship
RoleLead
Funding Start2008
Funding Finish2008
GNoG0188616
Type Of FundingOther Public Sector - State
Category2OPS
UONY

20051 grants / $37,000

Safe driving initative$37,000

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Funding body: NRMA Foundation Pty Ltd

Funding bodyNRMA Foundation Pty Ltd
Project Team
SchemeDonation to the John Hunter Trauma Service
RoleLead
Funding Start2005
Funding Finish2005
GNo
Type Of FundingDonation - Aust Non Government
Category3AFD
UONY
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Research Supervision

Current Supervision

CommencedResearch Title / Program / Supervisor Type
2014Defining the Immune System and Preventable Mortality in Geriatric Hip Fractures
Surgery, Faculty of Health and Medicine
Principal Supervisor
2012The Role of Mitochondrial DNA in the Post-Injury "Inflammatory" Response Following Major Trauma
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2011Understanding the Role of Prehospital Intubation and Advanced Brain Imaging in Patients Suffering from Severe Traumatic Brain Injury
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2010The Definition of Polytrauma - The Need for International Consensus
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2008Post Injury Multiple Organ Failure
Surgery, Faculty of Health and Medicine
Principal Supervisor

Past Supervision

YearResearch Title / Program / Supervisor Type
2014The Optimal Timing of Surgical Fracture Stabilization in Trauma Patients
General Medicine, Faculty of Health and Medicine
Principal Supervisor
2011The Effects of Fluid Resuscitation on Intra-Abdominal Pressure
Surgery, Faculty of Health and Medicine
Principal Supervisor
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News

second hit

Multiple Organ Failure - The Second Hit

August 8, 2014

Professor Zsolt Balogh's trauma research was featured on the ABC's Catalyst program last night.

Professor Zsolt Balogh

Organ failure syndrome

December 18, 2013

The battle to save accident victims in Intensive Care often extends beyond treating the original injury, with multiple organ failure (MOF) presenting a constant threat. While the precise cause of the body's sequential 'shut down' is unknown, results from a recent Hunter Medical Research Institute (HMRI) study may help to solve the puzzle.

Professor Zsolt Balogh

Position

Professor of Surgery
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Emailzsolt.balogh@newcastle.edu.au
Phone4921 4259
Fax4985 5545

Office

BuildingJohn Hunter Hospital
LocationRoyal Newcastle Centre, Bone & Joint Institute, Level 3, Lookout Road, New Lambton Heights NSW 2305

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