Dr Emily Hoedt
Postdoctoral Researcher
School of Biomedical Sciences and Pharmacy
- Email:emily.hoedt@newcastle.edu.au
- Phone:(02) 4042 0384
Solving real-world problems with microbial discoveries
Biotechnology graduate and research fellow Dr Emily Hoedt is making exciting discoveries in the field of microbiology. From optimising soldier cognition to improving surgical outcomes, she's showing what a big difference small things can make.
Emily is a trained microbiologist examining microbial communities with computer-based analyses (metagenomics) to study the diversity, roles, and responses of microbes in different environments, focusing on how they function and adapt under various environmental conditions.
She currently works at the University of Newcastle as a member of the Centre of Research (CRE) in Digestive Health team, overseeing all aspects of microbiome research.
The present focus of her efforts is on attempting to understand how to manipulate microbiome ecosystems through nutrient and/or community dynamics.
A big fascination with tiny organisms
“I’ve always found microbiology fascinating,” says Emily.
“The fact that there are these tiny microbes working unseen to make a living in the environment around us (even in the harshest conditions) and within our bodies goes underappreciated.
“Our relationship with microbes is complex and still largely unclear. We can only grow 29 per cent of the microbes that live in our gut, so there’s so much to uncover, and this is what drew me into microbiology. Discovering a new microbe, understanding it and even naming it was very exciting.”
An influencer of microbiology
To date, Emily’s microbiology and microbiome research has influenced fundamental microbiological understandings.
Her development of methods to isolate and culture-specific microbes resulted in the recovery of metabolically novel microbes. It also improved the feasibility of shotgun metagenomics from low microbial load samples—making it easier to study the microbes when there aren’t many in a sample.
This is significant as typically small samples have presented challenges for analysing the genetic material (DNA and RNA) of complex microbial communities.
Emily has also contributed to the understanding of the functional capability of the gut microbiota, and the identification of food-microbiome interactions is influencing dietetic practice in digestive health and wellbeing.
Her work involves collecting biopsies and stool samples from the gut to profile the microbes that live there. Using computer-based analyses, she can then target them for growth and recovery and test how they interact with human cells.
One of her contributions in this area includes the identification of key microbes in Crohn’s disease, which has progressed understanding of inflammatory bowel disease.
From infant formulas to soldier cognition
In 2018, Emily relocated to Ireland to undertake work with APC Microbiome—a role that required her to plan, manage and liaise with an industry partner.
The assignment involved the molecular (DNA) interrogation (in silico-computer based) and manipulation (in vitro-testing DNA function in the lab) of bifidobacterial strains. It also included assessing potential host and microbiota (in vivo- lab model) benefits during gastrointestinal distress (antibiotic and/or pathogen) to determine the commercial viability of the bifidobacterial strains as a probiotic product.
This research contributed to the exciting development of a probiotic formulation that may recover infant gut microbiomes after antibiotic treatment. It also expanded her professional network and experience in international science.
Emily has also collaborated widely on several other projects investigating the broad impact the microbiome has in areas such as digestive health diseases and disorders and brain function and performance.
One is a joint $3.5 million project funded by the Department of Defence.
Harnessing the unique relationship between the gut and brain, this research investigates the gun-brain axis in relation to cognitive performance in soldiers.
"The overall hypothesis is that gut microbiome composition and function is associated with cognitive performance and mental fitness/resilience. And that strategies to modulate the microbiome can be developed to optimise cognitive performance under the extreme pressures of operating in contested/complex environment," says Emily.
Improving colorectal surgical outcomes
One of Emily's major focuses currently is the microbes associated with unsuccessful colorectal resections.
Colorectal resection is the mainstay treatment for many diseases that require surgery. This includes colorectal cancer, diverticular disease, and inflammatory bowel disease.
The rejoining (anastomosis) and healing of the remaining tissue is not always successful and can result in sepsis (intestinal contents escaping into the abdomen: anastomotic leak).
This event has devastating consequences for the patient, says Emily.
"Most have salvage surgery, but some don’t survive the infective insult (~16.4 per cent mortality rate). Despite progress in many aspects of surgical care, leak rates remain high, between 10-15 per cent in large series and cohort studies."
There is indisputable evidence of the gastrointestinal microbiota's role in the host's homeostatic function, gastrointestinal disease, and wound healing.
Therefore, Emily's research aims to identify biomarkers from the tissue microbiota at the site of the anastomosis that are associated with anastomotic leak and design an appropriate intervention to target this biomarker and improve colorectal surgical outcomes (anastomotic leaks).
"This will be achieved using metagenomic shotgun sequencing and metatranscriptomics to inform us of the microbiota community composition, functional capability, and specific microbial gene expression," she continues.
She was recently one of two Newcastle scientists to receive a $500,000 NSW Health Early-Mid Career Researcher Grant to fund this work.
Changing the world with her voice
A discovery Emily is most proud of is when she isolated a new type of methane-producing microbe from a kangaroo that no one else had seen before. She was the first to report on a new way to make methane (ethanol and methanol).
Unfortunately, she didn't get to name this bug.
While her work in microbiology is highly valuable in its approach and applications, Emily admits that she finds it hard to feel like she's changing the world from the lab and by publishing academic papers.
Because of this, she's always keen to accept any opportunity to present her research and excitement about the microbiome to the wider community.
In the past, Emily has spoken at events such as Parkinson's community seminars, Men's Probus Club colorectal cancer seminar, HMRI Healthy Ageing community seminar, HMRI donor events, and GP education events.
Solving real-world problems with microbial discoveries
Dr Emily Hoedt is making exciting discoveries in the field of microbiology. From optimising soldier cognition to improving surgical outcomes, she's showing what a big difference small things can make.
Career Summary
Biography
My Research:
I’m a microbiologist with expertise in studying tiny organisms called microbes. My research focuses on understanding the communities of microbes that reside within our bodies, a field known as microbiome research. I have worked on a range of projects involving these microbes, exploring their roles in areas like digestive health, the development of probiotics, and wound healing. I am proud to be conducting my research within the Centre of Research (CRE) in Digestive Health team. My dedication to advancing science is matched only by my commitment to nurturing collaborations between academia and industry.
Education and Expertise:
My academic foundation includes a BBioTech Hons I and a PhD in Microbiology Biotechnology, both proudly earned from the University of Queensland, Australia in 2017. During my PhD I studied how different types of animal and human methane-making microbes in the gut make a living and how they compare to each other. This groundbreaking study not only expanded our comprehension of these enigmatic organisms but also earned me an Australian Postgraduate Award and an industry top-up scholarship from Meat and Livestock Australia.
Leading the way on evidence for probiotics:
In 2018, following on from my PhD, a new chapter unfolded as in Ireland where I lead an Academic-Industry collaboration at APC Microbiome Ireland. In this role as lead Postdoctoral Researcher, I liaised closely with our industry partner, Danone Nutricia, to drive investigations of the potential of bifidobacterial strains, showing their ability to alleviate gastrointestinal distress and bolster overall well-being. This work didn't just broaden our scientific understanding; it paved a path for probiotic products with tangible commercial viability.
Identifying markers of (un)successful colorectal resections:
One of my current research focuses is the investigation of the intricate world of microbial impact on wound healing in colorectal resections. These surgeries are the mainstay treatment for colorectal cancer and can result in surgical complications where the wound fails to heal, and the intestinal content escapes the join. Despite advances, these leaks continue to pose challenges, with a mortality rate of around 16.4%. My research aims to shed light on this complexity by exploring how the gut's microbial community influences surgical outcomes. By identifying biomarkers within the tissue microbiota at anastomosis sites, I envision targeted interventions to enhance surgical success. Leveraging advanced techniques like metagenomic sequencing, I decode microbial composition, capabilities, and gene expression. Recently, I secured substantial funding—a $500,000 boost from the NSW Health ECR award—to advance this critical work. As I decode the microbial puzzle, my research holds the potential to reshape surgical care, ultimately improving patient outcomes and lives.
Untangling the gut-brain-axis:
My interest also expands to the gut-brain axis in relation to cognitive performance, funded by the Department of Defence. Our overall hypothesis is that gut microbiome composition and function is associated with cognitive performance, and that strategies to modulate the microbiome can be developed to optimise cognitive performance and resilience. This is a multi-institutional project with University of Newcastle, QUT and industry partner Microba Life Sciences.
Qualifications
- Doctor of Philosophy, University of Queensland
- Bachelor of Biotechnology, University of Queensland
Keywords
- 16S rRNA amplicon sequencing
- Metagenomic shotgun sequencing
- Microbial genomics
- Microbial isolation
- Microbiome
- Pan-genomics
- methanogens
Languages
- English (Mother)
Fields of Research
Code | Description | Percentage |
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320203 | Clinical microbiology | 30 |
310704 | Microbial genetics | 30 |
310409 | Microbial taxonomy | 40 |
Professional Experience
UON Appointment
Title | Organisation / Department |
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Postdoctoral Researcher | University of Newcastle School of Biomedical Sciences and Pharmacy Australia |
Academic appointment
Dates | Title | Organisation / Department |
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25/6/2018 - 11/9/2020 | Postdoctoral Researcher | University College Cork Ireland |
1/5/2017 - 22/6/2018 | Postdoctoral Researcher | The University of Queensland Medicine Australia |
Awards
Award
Year | Award |
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2023 |
Judge's Choice The Bridgetech Program |
2022 |
People's Choice Award School of Biomedical Sciences and Pharmcy, The University of Newcastle |
2022 |
Best Oral Presentation: ECR winner School of Biomedical Sciences and Pharmcy, The University of Newcastle |
2016 |
CSIRO Agriculture and Food Directors Award; Next Generation category CSIRO - Commonwealth Scientific and Industrial Research Organisation |
2016 |
Travel award to Theo Murphy Australian Frontiers of Science symposium Theo Murphy Australian Frontiers of Science |
2012 |
Australian Postgraduate Award Australian Federal Government |
2012 |
Meat and Livestock Australia Postgraduate award Meat and Livestock Australia (MLA) |
Distinction
Year | Award |
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2011 |
Dean’s Commendation for High Achievement The University of Queensland |
Prize
Year | Award |
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2013 |
QAAFI Animal Science Olympics Elanco Innovation |
Publications
For publications that are currently unpublished or in-press, details are shown in italics.
Chapter (1 outputs)
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2021 |
Hoedt EC, Bongers RS, Bottacini F, Knol J, MacSharry J, van Sinderen D, 'Bifidobacterium Transformation', Methods in Molecular Biology 13-19 (2021) [B1] The protocol presented in this chapter describes a generic method for electrotransformation of Bifidobacterium spp., outlining a technique that is ideal for conferring selective p... [more] The protocol presented in this chapter describes a generic method for electrotransformation of Bifidobacterium spp., outlining a technique that is ideal for conferring selective properties onto strains as well as allowing the user to introduce or knock out/in selected genes for phenotypic characterization purposes. We have generalized on the plasmid chosen for transformation and antibiotic selection marker, but the protocol is versatile in this respect and we are able to achieve transformation efficiencies up to 107¿transformants/µg of DNA.
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Journal article (16 outputs)
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2023 |
Hoedt EC, Hueston CM, Cash N, Bongers RS, Keane JM, van Limpt K, et al., 'A synbiotic mixture of selected oligosaccharides and bifidobacteria assists murine gut microbiota restoration following antibiotic challenge', Microbiome, 11 [C1]
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2023 |
Vishnoi V, Hoedt EC, Gould T, Carroll G, Carroll R, Lott N, et al., 'A pilot study: intraoperative 16S rRNA sequencing versus culture in predicting colorectal incisional surgical site infection', ANZ Journal of Surgery, 93 2464-2472 (2023) [C1] Background: Surgical Site Infection (SSI) of the abdominal incision is a dreaded complication following colorectal surgery. Identifying the intraoperative surgical site microbes m... [more] Background: Surgical Site Infection (SSI) of the abdominal incision is a dreaded complication following colorectal surgery. Identifying the intraoperative surgical site microbes may provide clarity in the pathogenesis of SSIs. Genomic sequencing has revolutionized the ability to identify microbes from clinical samples. Utilization of 16S rRNA amplicon sequencing to characterize the intraoperative surgical site may provide the critical information required to predict and prevent infection in colorectal surgery. Methods: This is a pilot, prospective observational study of 50 patients undergoing elective colorectal resection. At completion of surgery, prior to skin closure, swabs were taken from the subcutaneous tissue of the abdominal incision to investigate the microbial profile. Dual swabs were taken to compare standard culture technique and 16S rRNA sequencing to establish if a microbial profile was associated with postoperative SSI. Results: 8/50 patients developed an SSI, which was more likely in those undergoing open surgery (5/15 33.3% versus 3/35, 8.6%; P = 0.029). 16S rRNA amplicon sequencing was more sensitive in microbial detection compared to traditional culture. Both culture and 16S rRNA demonstrated contamination of the surgical site, predominantly with anaerobes. Culture was not statistically predictive of infection. 16S rRNA amplicon sequencing was not statistically predictive of infection, however, it demonstrated patients with an SSI had an increased biodiversity (not significant) and a greater relative abundance (not significant) of pathogens such as Bacteroidacaea and Enterobacteriaceae within the intraoperative site. Conclusions: 16S rRNA amplicon sequencing has demonstrated a potential difference in the intraoperative microbial profile of those that develop an infection. These findings require validation through powered experiments to determine the overall clinical significance.
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2023 |
Volmer JG, Soo RM, Evans PN, Hoedt EC, Astorga Alsina AL, Woodcroft BJ, et al., 'Isolation and characterisation of novel Methanocorpusculum species indicates the genus is ancestrally host-associated', BMC Biology, 21 (2023) [C1] Background: With an increasing interest in the manipulation of methane produced from livestock cultivation, the microbiome of Australian marsupials provides a unique ecological an... [more] Background: With an increasing interest in the manipulation of methane produced from livestock cultivation, the microbiome of Australian marsupials provides a unique ecological and evolutionary comparison with ¿low-methane¿ emitters. Previously, marsupial species were shown to be enriched for novel lineages of Methanocorpusculum, as well as Methanobrevibacter, Methanosphaera, and Methanomassiliicoccales. Despite sporadic reports of Methanocorpusculum from stool samples of various animal species, there remains little information on the impacts of these methanogens on their hosts. Results: Here, we characterise novel host-associated species of Methanocorpusculum, to explore unique host-specific genetic factors and their associated metabolic potential. We performed comparative analyses on 176 Methanocorpusculum genomes comprising 130 metagenome-assembled genomes (MAGs) recovered from 20 public animal metagenome datasets and 35 other publicly available Methanocorpusculum MAGs and isolate genomes of host-associated and environmental origin. Nine MAGs were also produced from faecal metagenomes of the common wombat (Vombatus ursinus) and mahogany glider (Petaurus gracilis), along with the cultivation of one axenic isolate from each respective animal; M. vombati (sp. nov.) and M. petauri (sp. nov.). Conclusions: Through our analyses, we substantially expand the available genetic information for this genus by describing the phenotypic and genetic characteristics of 23 host-associated species of Methanocorpusculum. These lineages display differential enrichment of genes associated with methanogenesis, amino acid biosynthesis, transport system proteins, phosphonate metabolism, and carbohydrate-active enzymes. These results provide insights into the differential genetic and functional adaptations of these novel host-associated species of Methanocorpusculum and suggest that this genus is ancestrally host-associated.
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2022 |
Giri R, Hoedt EC, Khushi S, Salim AA, Bergot A-S, Schreiber V, et al., 'Secreted NF- B suppressive microbial metabolites modulate gut inflammation.', Cell Rep, 39 110646 (2022) [C1]
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2022 |
Cuskelly A, Hoedt EC, Harms L, Talley NJ, Tadros MA, Keely S, Hodgson DM, 'Neonatal immune challenge influences the microbiota and behaviour in a sexually dimorphic manner', BRAIN BEHAVIOR AND IMMUNITY, 103 232-242 (2022) [C1]
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2021 |
Hoedt EC, Bottacini F, Cash N, Bongers RS, van Limpt K, Ben Amor K, et al., 'Broad Purpose Vector for Site-Directed Insertional Mutagenesis in Bifidobacterium breve', Frontiers in Microbiology, 12 (2021) [C1] Members of the genus Bifidobacterium are notoriously recalcitrant to genetic manipulation due to their extensive and variable repertoire of Restriction-Modification (R-M) systems.... [more] Members of the genus Bifidobacterium are notoriously recalcitrant to genetic manipulation due to their extensive and variable repertoire of Restriction-Modification (R-M) systems. Non-replicating plasmids are currently employed to achieve insertional mutagenesis in Bifidobacterium. One of the limitations of using such insertion vectors is the presence within their sequence of various restriction sites, making them sensitive to the activity of endogenous restriction endonucleases encoded by the target strain. For this reason, vectors have been developed with the aim of methylating and protecting the vector using a methylase-positive Escherichia coli strain, in some cases containing a cloned bifidobacterial methylase. Here, we present a mutagenesis approach based on a modified and synthetically produced version of the suicide vector pORI28 (named pFREM28), where all known restriction sites targeted by Bifidobacterium breve R-M systems were removed by base substitution (thus preserving the codon usage). After validating the integrity of the erythromycin marker, the vector was successfully employed to target an a-galactosidase gene responsible for raffinose metabolism, an alcohol dehydrogenase gene responsible for mannitol utilization and a gene encoding a priming glycosyltransferase responsible for exopolysaccharides (EPS) production in B. breve. The advantage of using this modified approach is the reduction of the amount of time, effort and resources required to generate site-directed mutants in B. breve and a similar approach may be employed to target other (bifido)bacterial species.
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2021 |
Teh JJ, Berendsen EM, Hoedt EC, Kang S, Zhang J, Zhang F, et al., 'Novel strain-level resolution of Crohn s disease mucosa-associated microbiota via an ex vivo combination of microbe culture and metagenomic sequencing', ISME Journal, 15 3326-3338 (2021) [C1] The mucosa-associated microbiota is widely recognized as a potential trigger for Crohn¿s disease pathophysiology but remains largely uncharacterised beyond its taxonomic compositi... [more] The mucosa-associated microbiota is widely recognized as a potential trigger for Crohn¿s disease pathophysiology but remains largely uncharacterised beyond its taxonomic composition. Unlike stool microbiota, the functional characterisation of these communities using current DNA/RNA sequencing approaches remains constrained by the relatively small microbial density on tissue, and the overwhelming amount of human DNA recovered during sample preparation. Here, we have used a novel ex vivo approach that combines microbe culture from anaerobically preserved tissue with metagenome sequencing (MC-MGS) to reveal patient-specific and strain-level differences among these communities in post-operative Crohn¿s disease patients. The 16 S rRNA gene amplicon profiles showed these cultures provide a representative and holistic representation of the mucosa-associated microbiota, and MC-MGS produced both high quality metagenome-assembled genomes of recovered novel bacterial lineages. The MC-MGS approach also produced a strain-level resolution of key Enterobacteriacea and their associated virulence factors and revealed that urease activity underpins a key and diverse metabolic guild in these communities, which was confirmed by culture-based studies with axenic cultures. Collectively, these findings using MC-MGS show that the Crohn¿s disease mucosa-associated microbiota possesses taxonomic and functional attributes that are highly individualistic, borne at least in part by novel bacterial lineages not readily isolated or characterised from stool samples using current sequencing approaches.
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2021 |
Zhang J, Hoedt EC, Liu Q, Berendsen E, Teh JJ, Hamilton A, et al., 'Elucidation of Proteus mirabilis as a Key Bacterium in Crohn's Disease Inflammation', GASTROENTEROLOGY, 160 317-+ (2021) [C1]
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2018 |
Cuiv PO, Giri R, Hoedt EC, McGuckin MA, Begun J, Morrison M, '&ITEnterococcus faecalis&IT AHG0090 is a Genetically Tractable Bacterium and Produces a Secreted Peptidic Bioactive that Suppresses Nuclear Factor Kappa B Activation in Human Gut Epithelial Cells', FRONTIERS IN IMMUNOLOGY, 9 (2018)
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2018 |
Hoedt EC, Parks DH, Volmer JG, Rosewarne CP, Denman SE, McSweeney CS, et al., 'Culture- and metagenomics-enabled analyses of the Methanosphaera genus reveals their monophyletic origin and differentiation according to genome size', ISME JOURNAL, 12 2942-2953 (2018)
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2016 |
Burman S, Hoedt EC, Pottenger S, Mohd-Najman NS, Ó Cuív P, Morrison M, 'An (Anti)-Inflammatory Microbiota: Defining the Role in Inflammatory Bowel Disease?', Digestive Diseases, 34 64-71 (2016) [C1]
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2016 |
Hoedt EC, Cuív P, Evans PN, Smith WJM, McSweeney CS, Denman SE, Morrison M, 'Differences down-under: Alcohol-fueled methanogenesis by archaea present in Australian macropodids', ISME Journal, 10 2376-2388 (2016) [C1]
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Show 13 more journal articles |
Review (14 outputs)
Year | Citation | Altmetrics | Link | ||||||||
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2024 |
Senanayake T, Makanyengo S, Hoedt EC, Goggins B, Smith SR, Keely S, 'Influence of the bile acid/microbiota axis in ileal surgery: a systematic review', Colorectal Disease (2024) [C1]
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2023 |
Talley NJ, Burns GL, Hoedt EC, Duncanson K, Keely S, 'Beyond Eosinophilic Esophagitis: Eosinophils in Gastrointestinal Disease-New Insights, "New" Diseases.', J Can Assoc Gastroenterol (2023) [C1]
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2023 |
Cameron R, Duncanson K, Hoedt EC, Eslick GD, Burns GL, Nieva C, et al., 'Does the microbiome play a role in the pathogenesis of colonic diverticular disease? A systematic review.', J Gastroenterol Hepatol (2023) [C1]
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2023 |
Eslick GD, Fan K, Nair PM, Burns GL, Hoedt EC, Keely S, Talley NJ, 'Clinical and Pathologic Factors Associated With Colonic Spirochete (Brachyspira pilosicoli and Brachyspira aalborgi) Infection: A Comprehensive Systematic Review and Pooled Analysis.', Am J Clin Pathol (2023) [C1]
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2023 |
Vishnoi V, Morey T, Hoedt EC, Keely S, Pockney P, Smith SR, 'A Systematic Review and Meta-Analysis of Intra-Operative Surgical Site Sampling: Culture versus Culture-Independent Techniques in Predicting Downstream Surgical Site Infection.', Surgical infections (2023) [C1]
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2023 |
Nieva C, Pryor J, Williams GM, Hoedt EC, Burns GL, Eslick GD, et al., 'The Impact of Dietary Interventions on the Microbiota in Inflammatory Bowel Disease: A Systematic Review.', J Crohns Colitis (2023) [C1]
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2022 |
Hari S, Burns GL, Hoedt EC, Keely S, Talley NJ, 'Eosinophils, Hypoxia-Inducible Factors, and Barrier Dysfunction in Functional Dyspepsia', Frontiers in Allergy [C1]
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2022 |
Brown G, Hoedt EC, Keely S, Shah A, Walker MM, Holtmann G, Talley NJ, 'Role of the duodenal microbiota in functional dyspepsia', Neurogastroenterology and Motility (2022) [C1] Background: Functional dyspepsia (FD) is a common and debilitating gastrointestinal disorder attributed to altered gut-brain interactions. While the etiology of FD remains unknown... [more] Background: Functional dyspepsia (FD) is a common and debilitating gastrointestinal disorder attributed to altered gut-brain interactions. While the etiology of FD remains unknown, emerging research suggests the mechanisms are likely multifactorial and heterogenous among patient subgroups. Small bowel motor disturbances, visceral hypersensitivity, chronic microinflammation, and increased intestinal tract permeability have all been linked to the pathogenesis of FD. Recently, alterations to the gut microbiome have also been implicated to play an important role in the disease. Changes to the duodenal microbiota may either trigger or be a consequence of immune and neuronal disturbances observed in the disease, but the mechanisms of influence of small intestinal flora on gastrointestinal function and symptomatology are unknown. Purpose: This review summarizes and synthesizes the literature on the link between the microbiota, low-grade inflammatory changes in the duodenum and FD. This review is not intended to provide a complete overview of FD or the small intestinal microbiota, but instead outline some of the key conceptual advances in understanding the interactions between altered gastrointestinal bacterial communities; dietary factors; host immune activation; and stimulation of the gut¿brain axes in patients with FD versus controls. Current and emerging treatment approaches such as dietary interventions and antibiotic or probiotic use that have demonstrated symptom benefits for patients are reviewed, and their role in modulating the host¿microbiota is discussed. Finally, suggested opportunities for diagnostic and therapeutic improvements for patients with this condition are presented.
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2022 |
Fan K, Eslick GD, Nair PM, Burns GL, Walker MM, Hoedt EC, et al., 'Human intestinal spirochetosis, irritable bowel syndrome, and colonic polyps: A systematic review and meta-analysis', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2022) [C1]
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2022 |
Fowler S, Hoedt EC, Talley NJ, Keely S, Burns GL, 'Circadian Rhythms and Melatonin Metabolism in Patients With Disorders of Gut-Brain Interactions', FRONTIERS IN NEUROSCIENCE (2022) [C1]
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2022 |
Almeida KA, Andrade EDQ, Burns G, Hoedt EC, Mattes J, Keely S, Collison A, 'The microbiota in eosinophilic esophagitis: A systematic review', JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY (2022) [C1]
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2021 |
Burns GL, Hoedt EC, Walker MM, Talley NJ, Keely S, 'Physiological mechanisms of unexplained (functional) gastrointestinal disorders', JOURNAL OF PHYSIOLOGY-LONDON (2021) [C1]
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2016 |
Hoedt EC, Cuív P, Morrison M, 'Methane matters: From blue-tinged moos, to boozy roos, and the health of humans too', Animal Frontiers (2016) [C1]
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Show 11 more reviews |
Conference (19 outputs)
Year | Citation | Altmetrics | Link | ||||||||
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2023 |
Wark JA, Burns GL, Hoedt EC, Dowling LR, Soh WS, Sherwin S, et al., 'A NOVEL DUODENAL ISOLATE OF
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2023 |
Thacker N, Collins CE, Duncanson K, O'Loughlin EV, Dutt S, Hoedt EC, et al., 'ANTIBIOTICS, URBAN ENVIRONMENT AND WESTERN DIET PATTERN INCREASE RISK OF PAEDIATRIC INFLAMMATORY BOWEL DISEASE: A META-ANALYSIS', GASTROENTEROLOGY (2023)
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2022 |
Burns GL, Hoedt EC, Jamaluddin MFB, Shanahan E, Lim Y, Teh JJ, et al., 'Seroreactivity to mucosa associated microbiota is associated with T cell gut-homing in functional dyspepsia patients (Withdrawal of Vol 36, 10.1096/FASEBJ.2022.36.S1.R4212, 2022)', FASEB JOURNAL (2022)
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2016 |
Hoedt EC, OCuiv P, Morrison M, 'Methane matters: From blue tinged moos, to boozy roos, and for the health of humans too', JOURNAL OF ANIMAL SCIENCE (2016)
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Show 16 more conferences |
Preprint (1 outputs)
Year | Citation | Altmetrics | Link | ||
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2018 |
Cuív PÓ, Giria R, Hoedt EC, McGuckin MA, Begun J, Morrison M, '
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Grants and Funding
Summary
Number of grants | 7 |
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Total funding | $9,037,975 |
Click on a grant title below to expand the full details for that specific grant.
Highlighted grants and funding
Using metagenomic shotgun sequencing to identify the impact of peri-operative measures on the microbiota to prevent anastomotic leaks in colorectal surgeries$499,987
Funding body: NSW Ministry of Health
Funding body | NSW Ministry of Health |
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Project Team | Doctor Emily Hoedt, Doctor Alexandra Adams, Professor Guy Eslick, Professor Simon Keely, Doctor Peter Pockney |
Scheme | Early-Mid Career Researcher Grant |
Role | Lead |
Funding Start | 2023 |
Funding Finish | 2025 |
GNo | G2300020 |
Type Of Funding | C2400 – Aust StateTerritoryLocal – Other |
Category | 2400 |
UON | Y |
Optimising the Warfighter cognobiome: novel microbiome interventions to improve the cognitive performance of Warfighters$3,503,200
Funding body: Department of Defence
Funding body | Department of Defence |
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Project Team | Laureate Professor Nick Talley, Professor Simon Keely, Doctor Emily Hoedt, Doctor Grace Burns, Professor Ami Eidels, Doctor Kerith Duncanson, Professor Scott Brown, Gene Tyson, Professor Gene Tyson, Professor Mark Morrison, Professor Gerald Holtmann, Robert Speight, Professor Robert Speight, Tony Kenna, Lutz Krause, Ottmar Lipp, Yi-Chin Toh, Paraic O Cuiv, Professor Ottmar Lipp, Associate Professor Tony Kenna, Associate Professor Yi-Chin Toh |
Scheme | Breakthrough Human Performance Research Call |
Role | Investigator |
Funding Start | 2021 |
Funding Finish | 2024 |
GNo | G2100173 |
Type Of Funding | C1500 - Aust Competitive - Commonwealth Other |
Category | 1500 |
UON | Y |
A web-based interface for diet-microbiome-disease models$30,000
Funding body: NHMRC Centre of Research Excellence in Digestive Health
Funding body | NHMRC Centre of Research Excellence in Digestive Health |
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Project Team | Kerith Duncanson, Emily C. Hoedt |
Scheme | 2020 Pilot Grant |
Role | Investigator |
Funding Start | 2021 |
Funding Finish | 2022 |
GNo | |
Type Of Funding | C1100 - Aust Competitive - NHMRC |
Category | 1100 |
UON | N |
20232 grants / $3,423,096
The Australian Human Microbiome Biobank $2,923,109
Funding body: Medical Research Futures Fund (MRFF)
Funding body | Medical Research Futures Fund (MRFF) |
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Project Team | Professor Gene William Tyson, Professor Trent Munro, Professor Fiona Melanie Wood, Professor Gerald Holtman, Doctor Páraic Ó'CuÍv, Doctor Asha Bowen, Professor Benjamin Howden, Doctor Nicola Angel, Doctor Simon Jon McIlroy, Doctor Elise Sarah Pelzer, Doctor Emily Hoedt, Doctor Allison Skinner McInnes, Doctor James Gregory Volmer |
Scheme | National Critical Research Infrastructure |
Role | Investigator |
Funding Start | 2023 |
Funding Finish | 2026 |
GNo | |
Type Of Funding | C1300 - Aust Competitive - Medical Research Future Fund |
Category | 1300 |
UON | N |
Using metagenomic shotgun sequencing to identify the impact of peri-operative measures on the microbiota to prevent anastomotic leaks in colorectal surgeries$499,987
Funding body: NSW Ministry of Health
Funding body | NSW Ministry of Health |
---|---|
Project Team | Doctor Emily Hoedt, Doctor Alexandra Adams, Professor Guy Eslick, Professor Simon Keely, Doctor Peter Pockney |
Scheme | Early-Mid Career Researcher Grant |
Role | Lead |
Funding Start | 2023 |
Funding Finish | 2025 |
GNo | G2300020 |
Type Of Funding | C2400 – Aust StateTerritoryLocal – Other |
Category | 2400 |
UON | Y |
20215 grants / $5,614,879
Optimising the Warfighter cognobiome: novel microbiome interventions to improve the cognitive performance of Warfighters$3,503,200
Funding body: Department of Defence
Funding body | Department of Defence |
---|---|
Project Team | Laureate Professor Nick Talley, Professor Simon Keely, Doctor Emily Hoedt, Doctor Grace Burns, Professor Ami Eidels, Doctor Kerith Duncanson, Professor Scott Brown, Gene Tyson, Professor Gene Tyson, Professor Mark Morrison, Professor Gerald Holtmann, Robert Speight, Professor Robert Speight, Tony Kenna, Lutz Krause, Ottmar Lipp, Yi-Chin Toh, Paraic O Cuiv, Professor Ottmar Lipp, Associate Professor Tony Kenna, Associate Professor Yi-Chin Toh |
Scheme | Breakthrough Human Performance Research Call |
Role | Investigator |
Funding Start | 2021 |
Funding Finish | 2024 |
GNo | G2100173 |
Type Of Funding | C1500 - Aust Competitive - Commonwealth Other |
Category | 1500 |
UON | Y |
Wheat proteins, the duodenal microbiome and immune activation in the aetiopathogenesis of non-coeliac gluten sensitivity and functional dyspepsia$2,052,979
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Simon Keely, Doctor Kerith Duncanson, Doctor Michael Potter, Doctor Natasha Koloski, Dr Emily Hoedt, Doctor Emily Hoedt, Miss Cheenie Nieva |
Scheme | Ideas Grants |
Role | Investigator |
Funding Start | 2021 |
Funding Finish | 2023 |
GNo | G2000682 |
Type Of Funding | C1100 - Aust Competitive - NHMRC |
Category | 1100 |
UON | Y |
A web-based interface for diet-microbiome-disease models$30,000
Funding body: NHMRC Centre of Research Excellence in Digestive Health
Funding body | NHMRC Centre of Research Excellence in Digestive Health |
---|---|
Project Team | Kerith Duncanson, Emily C. Hoedt |
Scheme | 2020 Pilot Grant |
Role | Investigator |
Funding Start | 2021 |
Funding Finish | 2022 |
GNo | |
Type Of Funding | C1100 - Aust Competitive - NHMRC |
Category | 1100 |
UON | N |
The developing microbiome as predictor of autism spectrum disorders - NEW1000 HMRI $23,750
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Simon Keely, Doctor Annalisa Cuskelly, Professor Guy Eslick, Doctor Emily Hoedt, Professor Craig Pennell, Laureate Professor Nick Talley |
Scheme | Research Grant |
Role | Investigator |
Funding Start | 2021 |
Funding Finish | 2022 |
GNo | G2101271 |
Type Of Funding | C3300 – Aust Philanthropy |
Category | 3300 |
UON | Y |
Pilot data collection for analysis of the microbiome and pregnancy outcomes in the Newcastle 1000 study.$4,950
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Doctor Emily Hoedt, Doctor Grace Burns, Doctor Tegan Grace |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2021 |
Funding Finish | 2021 |
GNo | G2100165 |
Type Of Funding | C3300 – Aust Philanthropy |
Category | 3300 |
UON | Y |
Research Supervision
Number of supervisions
Current Supervision
Commenced | Level of Study | Research Title | Program | Supervisor Type |
---|---|---|---|---|
2022 | PhD | Investigating The Influence Of Prebiotic Fibres On Microbiological Factors That Mediate Cognition. | PhD (Nutritional Biochemistry), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2022 | PhD | Investigating Circadian Rhythms and Melatonin Metabolism in Patients with Functional Gastrointestinal Disorders | PhD (Immunology & Microbiol), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2021 | PhD | Immune Screening as a Predictor of Food Triggers for Relapse in Crohn’s Disease. | PhD (Immunology & Microbiol), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2021 | PhD | A Mouse Model of Ileocolic Resection and the Changes in Microbiome and Bile Acid Physiology | PhD (Surgical Science), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2020 | PhD | Microbiome and Immune-Phenotyping of Dietary Wheat Sensitivity | PhD (Immunology & Microbiol), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
Past Supervision
Year | Level of Study | Research Title | Program | Supervisor Type |
---|---|---|---|---|
2023 | PhD | Investigating Colonic Spirochaetosis in Association with Irritable Bowel Syndrome | PhD (Immunology & Microbiol), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2023 | PhD | The Microbiota of the Abdominal Wall Surgical Site in Colorectal Surgery | PhD (Anatomy), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
News
News • 31 Jul 2023
$1m supports immunology and microbiology researchers
Two Newcastle scientists are among six promising researchers recognised with a prestigious NSW Government grant designed to support and build health and medical research talent in NSW.
News • 10 Dec 2021
Research investigates how the gut wages war on the brains of soldiers
Harnessing the unique relationship between the gut and brain, new research will interrogate Australian soldiers’ gut microbiome to optimise their cognitive and psychological performance in combat.
Dr Emily Hoedt
Position
Postdoctoral Researcher
Nick Talley
School of Biomedical Sciences and Pharmacy
College of Health, Medicine and Wellbeing
Contact Details
emily.hoedt@newcastle.edu.au | |
Phone | (02) 4042 0384 |
Office
Room | HMRI Building, Level 3 East Wing, Desk 167 |
---|---|
Building | HMRI |
Location | HMRI, New Lambton Heights, New South Wales , |