Dr Frederick Walker

Dr Frederick Walker

Associate Professor

School of Biomedical Sciences and Pharmacy (Anatomy)

Rethinking depression

Associate Professor Rohan Walker is advancing a scientific premise that could transform treatment for mood disorders.

Rohan Walker on stairs 

Associate Professor Rohan Walker is part of a growing international band of scientists whose work is challenging conventional thinking about the neurochemical causes of depression. Walker leads a research group investigating brain cell inflammation as a primary cause of psychological disorders. Their research looks into the role of microglia cells, a key part of the immune defence of the central nervous system, and how those cells can be manipulated to mediate the effects of chronic stress.

Traditional drugs prescribed for severe depression act by adjusting the levels of neurotransmitters in the brain but the specific role neurotransmitters play in the development or treatment of clinical depression is not clearly understood by the medical or scientific fields. Also, these common anti-depressants – taken by an estimated one million Australians – often produce side effects and their efficacy varies considerably.

"As scientists we would like to design better medications but the major roadblock is that there is no solid understanding of the precise changes in the brain that lead to mood disorders," Walker maintains. "What has motivated me to take my research down this new path is the compelling body of evidence emerging from around the world that suggests inflammatory processes are strongly involved in depression."

Walker's interest in inflammatory processes in the brain was inspired by his postdoctoral research into the neurobiological mechanisms of stress and the factors that determine vulnerability to mood disorders. His studies drew a parallel between the behaviours that people display when they have a physical ailment such as a cold and those commonly reported by people who are depressed – symptoms such as fatigue, loss of appetite and libido, disrupted sleep and demotivation.

"It seemed more than a striking coincidence that the two were so similar," Walker says. "We know from previous work that sickness behaviours are influenced by microglia, so that prompted me to start thinking about whether microglia could be involved in regulating depression and psychological illness."

Although only three years into the research program, Walker and his colleagues have already made a novel discovery that has advanced the neuroinflammation hypothesis. Their research established that exposure to chronic stress changes the behaviour of microglia in the brain and that chemically inactivating microglia can reduce stress-related emotional response. Their findings were published last year in the high-level journal Cerebral Cortex, a publication that has increased the international profile of their work and opened up collaborations withresearch groups at other institutions, including the University of Queensland and La Trobe University.

Walker completed both his undergraduate and doctoral studies at the University of Newcastle and has worked full-time in research since being awarded his PhD in 2006. He received a Peter Doherty Early Career Fellowship from the National Health and Medical Research Council (NHMRC) in 2007. He is the convenor of the Affective and Addictive Disorders Program within the University's Centre for Brain and Mental Health and his research into neuroinflammation and novel anti-depressant strategies is supported by a NHMRC grant of more than $346,000.

"The Centre is a fantastic network of more than 100 academics and I collaborate with neuroscience researchers at the University and within the Hunter Medical Research Institute group," Walker states. "It is a very supportive and intellectually challenging environment in which to work."

Find out more

Rohan Walker on stairs

Rethinking depression

Associate Professor Rohan Walker is advancing a scientific premise that could transform treatment for mood disorders.

Read more

Career Summary

Biography

Associate Professor Walker is a senior research fellow based at the Hunter Medical Research Institute. He currently is chief investigator within the University of Newcastle's Priority Research Center in Stroke and Traumatic Brain Injury and a named research fellow for the NHMRC Center of Excellence in Stroke Recovery and Rehabilitation.

Associate Professor Walker obtained his PhD from the Univeristy of Newcastle in the field of Neuroimmunology in 2006. Dr Walker then joined the systems neuroscience laboratory of Professor Trevor Day, in the School of Biomedical Sciences & Pharmacy, as an NHMRC funded postdoctoral researcher. During this time he investigated brain mechanisms that underpin individual differences in vulnerability to psychological stress. In 2007 Dr Walker was awarded an NHMRC Biomedical (Peter Doherty) Postdoctoral Fellowship.  During this time his work became increasingly focused on the role of glia and neuroimmune alterations in mood disturbances. In 2009 he established the Affective Neuroscience and Neuroimmunology research group at the University of Newcastle, Australia. Over the past several years Dr Walker’s research has been focused on the role of neuroinflammation, mood disturbance and dementia. He has established himself as an emerging researcher leader in the field and is regularly invited to speak at national and international conferences, and  called upon to review NHMRC grant applications and scientific manuscripts.  His work is currently supported by the NHMRC and the Hunter Medical Research Institute and several philanthropic societies.

Research Expertise
The primary objective of our research group is to understand the relationship between brain injury, neuroinflammation and cognitive performance. Our research interfaces with a number of disease processes including; stroke; Alzheimers; and depression. Our research makes uses of a large variety of techniques spanning from the analysis of individual genes of interest through to the behavioural level. Our research laboratories, situated at with the School of Biomedical Sciences and Pharmacy, are ideally equipped with state of the art equipment to undertake these multi-level investigations.

Teaching Expertise
I have been fortunate to contribute to the teaching of the following courses: HUBS 1405 - Introduction to Biomedical Statistics HUBS 3403 - Neuroscience HUBS 3410 - Advanced Research Skills MED 2000 - Frontal Lobes and Cognition PSYCH 3040 - Advanced Psychobiology

Administrative Expertise
Member and Animal Services User Advisory Group 2012-2014 Member of the Centre for Translational Neuroscience and Mental Health management committee (Chair of the Affective and Addictive Disorders subgroup)

Collaborations
Dr Murray Cairns (University of Newcastle): Genome wide profiling of stress induced changes within the brain Professor Trevor Day (Deakin University): Neuroninflammatory modulation of mood state Professor Michael Nilsson (University of Newcastle): Glial remodelling in stroke

Qualifications

  • PhD, University of Newcastle
  • Bachelor of Arts (Honours), University of Newcastle

Keywords

  • Biomedical Statistics
  • Depression
  • Learning and Memory
  • Microglia
  • Neuroinflammation
  • Neuron-Glia interactions
  • Neuroscience
  • Psychoneuroimmunology
  • Research Design and Methodology
  • Stress

Fields of Research

Code Description Percentage
110999 Neurosciences not elsewhere classified 100

Professional Experience

UON Appointment

Title Organisation / Department
Associate Professor University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Academic appointment

Dates Title Organisation / Department
1/01/2011 - 1/12/2012 Fellow University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/2011 -  Research Fellow University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia
1/01/2007 - 1/12/2010 Peter Doherty Australian Biomedical Research Fellow NHMRC (National Health & Medical Research Council)
Australia
1/01/2007 - 1/12/2010 Fellow

NHMRC - Early Career Fellowships (Formerly Postdoctoral Training Fellowships)

NHMRC (National Health & Medical Research Council)
1/03/2005 - 1/02/2006 NHRMC Research Officer University of Newcastle
School of Biomedical Sciences and Pharmacy
Australia

Membership

Dates Title Organisation / Department
Conference Chair/ Member - Autonomic Neuroscience Workshop International Society for Autonomic Neuroscience
Australia

Awards

Research Award

Year Award
2005 Psychoneuroimmunology Research Society
Psychoneuroimmunology Research Society (PNIRS)

Invitations

Speaker

Year Title / Rationale
2012 The role of microglia in cognitive disturbance: a new frontier in the neurobiology of stress.
Organisation: University of Neewcastle Description: The Annual Australia and Society in Neuroscience. Symposia on Stress.
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (2 outputs)

Year Citation Altmetrics Link
2013 Walker FR, Nalivaiko E, Day TA, 'Stress and inflammation: An emerging story', Nutrition and Physical Activity in Inflammatory Diseases, CABI, Oxfordshire 260-272 (2013) [B1]
Co-authors Eugene Nalivaiko
2012 Day TA, Walker FR, 'An introduction to the neurobiology of emotions and social behavior', The Mouse Nervous System, Academic Press, San Diego 719-725 (2012) [B1]

Journal article (55 outputs)

Year Citation Altmetrics Link
2016 Rohan Walker F, Yirmiya R, 'Microglia, physiology and behavior: A brief commentary', Brain, Behavior, and Immunity, (2016)
DOI 10.1016/j.bbi.2016.03.006
2016 Ji P, Schachtschneider KM, Schook LB, Walker FR, Johnson RW, 'Peripheral viral infection induced microglial sensome genes and enhanced microglial cell activity in the hippocampus of neonatal piglets.', Brain Behav Immun, 54 243-251 (2016)
DOI 10.1016/j.bbi.2016.02.010
2015 Kongsui R, Johnson SJ, Graham BA, Nilsson M, Walker FR, 'A combined cumulative threshold spectra and digital reconstruction analysis reveal structural alterations of microglia within the prefrontal cortex following low-dose LPS administration', Neuroscience, 310 629-640 (2015) [C1]

© 2015 IBRO. Sickness behaviors have become the focus of great interest in recent years as they represent a clear case of how peripheral disturbances in immune signaling can disr... [more]

© 2015 IBRO. Sickness behaviors have become the focus of great interest in recent years as they represent a clear case of how peripheral disturbances in immune signaling can disrupt quite complex behaviors. In the current study, we were interested in examining whether we could identify any significant morphological disturbances in microglia associated with these sickness-like behaviors in adult male Sprague-Dawley rats. We chose lipopolysaccharide (LPS 100 µg/kg/i.p.), to induce sickness-like behaviors as it is the most well-validated approach to do so in rodents and humans. We were particularly interested in examining changes in microglia within the prefrontal cortex (PFC) as several recent neuroimaging studies have highlighted significant functional changes in this region following peripheral LPS administration. Paraformaldehyde-fixed tissue was collected from animals 24 h post LPS administration and labeled immunohistochemically with an antibody directed to bind to Iba-1, a protein known to be involved in the structural remodeling of microglia. To analyze changes, we have made use of two recently described image analysis procedures. The first is known as cumulative threshold spectra (CTS) analysis. The second involves the unsupervised digital reconstruction of microglia. We undertook these complementary analysis of microglial cells in the both the pre- and infralimbic divisions of the PFC. Our results indicated that microglial soma size was significantly enlarged, while cell processes had contracted slightly following LPS administration. To our knowledge this study is to first to definitely demonstrate substantial microglial disturbances within the PFC following LPS delivered at a dose that was sufficient to induce significant sickness-like behavior.

DOI 10.1016/j.neuroscience.2015.09.061
Co-authors Brett Graham, Sarah Johnson
2015 Muccigrosso MM, Ford J, Benner B, Moussa D, Burnsides C, Fenn AM, et al., 'Cognitive deficits develop 1month after diffuse brain injury and are exaggerated by microglia-associated reactivity to peripheral immune challenge', Brain, Behavior, and Immunity, (2015)

© 2016. Traumatic brain injury (TBI) elicits immediate neuroinflammatory events that contribute to acute cognitive, motor, and affective disturbance. Despite resolution of these ... [more]

© 2016. Traumatic brain injury (TBI) elicits immediate neuroinflammatory events that contribute to acute cognitive, motor, and affective disturbance. Despite resolution of these acute complications, significant neuropsychiatric and cognitive issues can develop and progress after TBI. We and others have provided novel evidence that these complications are potentiated by repeated injuries, immune challenges and stressors. A key component to this may be increased sensitization or priming of glia after TBI. Therefore, our objectives were to determine the degree to which cognitive deterioration occurred after diffuse TBI (moderate midline fluid percussion injury) and ascertain if glial reactivity induced by an acute immune challenge potentiated cognitive decline 30. days post injury (dpi). In post-recovery assessments, hippocampal-dependent learning and memory recall were normal 7. dpi, but anterograde learning was impaired by 30. dpi. Examination of mRNA and morphological profiles of glia 30. dpi indicated a low but persistent level of inflammation with elevated expression of GFAP and IL-1ß in astrocytes and MHCII and IL-1ß in microglia. Moreover, an acute immune challenge 30. dpi robustly interrupted memory consolidation specifically in TBI mice. These deficits were associated with exaggerated microglia-mediated inflammation with amplified (IL-1ß, CCL2, TNFa) and prolonged (TNFa) cytokine/chemokine expression, and a marked reactive morphological profile of microglia in the CA3 of the hippocampus. Collectively, these data indicate that microglia remain sensitized 30. dpi after moderate TBI and a secondary inflammatory challenge elicits robust microglial reactivity that augments cognitive decline. Statement of Significance: Traumatic brain injury (TBI) is a major risk factor in development of neuropsychiatric problems long after injury, negatively affecting quality of life. Mounting evidence indicates that inflammatory processes worsen with time after a brain injury and are likely mediated by glia. Here, we show that primed microglia and astrocytes developed in mice 1. month following moderate diffuse TBI, coinciding with cognitive deficits that were not initially evident after injury. Additionally, TBI-induced glial priming may adversely affect the ability of glia to appropriately respond to immune challenges, which occur regularly across the lifespan. Indeed, we show that an acute immune challenge augmented microglial reactivity and cognitive deficits. This idea may provide new avenues of clinical assessments and treatments following TBI.

DOI 10.1016/j.bbi.2016.01.009
2015 Hollins SL, Zavitsanou K, Walker FR, Cairns MJ, 'Alteration of transcriptional networks in the entorhinal cortex after maternal immune activation and adolescent cannabinoid exposure', Brain, Behavior, and Immunity, (2015)

© 2016 Elsevier Inc. Maternal immune activation (MIA) and adolescent cannabinoid exposure (ACE) have both been identified as major environmental risk factors for schizophrenia. W... [more]

© 2016 Elsevier Inc. Maternal immune activation (MIA) and adolescent cannabinoid exposure (ACE) have both been identified as major environmental risk factors for schizophrenia. We examined the effects of these two risk factors alone, and in combination, on gene expression during late adolescence. Pregnant rats were exposed to the viral infection mimic polyriboinosinic-polyribocytidylic acid (poly I:C) on gestational day (GD) 15. Adolescent offspring received daily injections of the cannabinoid HU210 for 14. days starting on postnatal day (PND) 35. Gene expression was examined in the left entorhinal cortex (EC) using mRNA microarrays. We found prenatal treatment with poly I:C alone, or HU210 alone, produced relatively minor changes in gene expression. However, following combined treatments, offspring displayed significant changes in transcription. This dramatic and persistent alteration of transcriptional networks enriched with genes involved in neurotransmission, cellular signalling and schizophrenia, was associated with a corresponding perturbation in the expression of small non-coding microRNA (miRNA). These results suggest that a combination of environmental exposures during development leads to significant genomic remodeling that disrupts maturation of the EC and its associated circuitry with important implications as the potential antecedents of memory and learning deficits in schizophrenia and other neuropsychiatric disorders.

DOI 10.1016/j.bbi.2016.02.021
Co-authors Murray Cairns
2015 Jones KA, Zouikr I, Patience M, Clarkson AN, Isgaard J, Johnson SJ, et al., 'Chronic stress exacerbates neuronal loss associated with secondary neurodegeneration and suppresses microglial-like cells following focal motor cortex ischemia in the mouse', Brain, Behavior, and Immunity, 48 57-67 (2015) [C1]
DOI 10.1016/j.bbi.2015.02.014
Citations Scopus - 2
Co-authors Neil Spratt, Sarah Johnson
2015 Clarkson AN, Parker K, Nilsson M, Walker FR, Gowing EK, 'Combined ampakine and BDNF treatments enhance poststroke functional recovery in aged mice via AKT-CREB signaling.', J Cereb Blood Flow Metab, 35 1272-1279 (2015) [C1]
DOI 10.1038/jcbfm.2015.33
2015 Mayhew J, Beart PM, Walker FR, 'Astrocyte and microglial control of glutamatergic signalling: a primer on understanding the disruptive role of chronic stress.', J Neuroendocrinol, 27 498-506 (2015) [C1]
DOI 10.1111/jne.12273
Citations Scopus - 4
2015 Iseme RA, McEvoy M, Kelly B, Agnew L, Attia J, Walker FR, et al., 'Autoantibodies are not predictive markers for the development of depressive symptoms in a population-based cohort of older adults', European Psychiatry, 30 694-700 (2015) [C1]
DOI 10.1016/j.eurpsy.2015.06.006
Co-authors John Attia, Brian Kelly, Christopher Oldmeadow, Mark Mcevoy
2014 Iseme RA, McEvoy M, Kelly B, Agnew L, Attia J, Walker FR, 'Autoantibodies and depression. Evidence for a causal link?', Neuroscience and Biobehavioral Reviews, 40 62-79 (2014) [C1]

Depression is a leading contributor to the global burden of diseases. Despite advances in research, challenges still exist in managing this disorder. Sufferers of autoimmune disea... [more]

Depression is a leading contributor to the global burden of diseases. Despite advances in research, challenges still exist in managing this disorder. Sufferers of autoimmune diseases are often observed to suffer from depression more often than healthy individuals, an association that cannot be completely accounted for by the impact of the disease on the individual. An association between autoimmunity and depressive symptoms also appears to exist in populations with subclinical symptoms. Moreover, researchers have successfully developed murine models illustrating the ability of autoantibodies to induce depressive-like symptoms. This paper will provide an overview of the association between autoantibodies and occurrence of depressive symptoms. Though current evidence appears to support a role for autoantibodies in the pathogenesis of depression, the majority of studies have examined this relationship cross-sectionally, therefore failing to establish a temporal association. Nonetheless, this novel theory meshes with older and newer neurochemical theories of depression. A better understanding of the immuno-pathogenesis underlying depression presents opportunities for more targeted treatment approaches and more timely and appropriate measures of detection. © 2014 Elsevier Ltd.

DOI 10.1016/j.neubiorev.2014.01.008
Citations Scopus - 10Web of Science - 4
Co-authors Mark Mcevoy, John Attia, Brian Kelly
2014 Walker FR, Jones KA, Patience MJ, Zhao Z, Nilsson M, 'Stress as necessary component of realistic recovery in animal models of experimental stroke', JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 34 208-214 (2014) [C1]
DOI 10.1038/jcbfm.2013.211
2014 Radler ME, Wright BJ, Walker FR, Hale MW, Kent S, 'Calorie restriction increases lipopolysaccharide-induced neuropeptide Y immunolabeling and reduces microglial cell area in the arcuate hypothalamic nucleus.', Neuroscience, 285 236-247 (2014) [C1]
DOI 10.1016/j.neuroscience.2014.11.014
Citations Scopus - 4Web of Science - 1
2014 Patience MJ, Zouikr I, Jones K, Clarkson AN, Isgaard J, Johnson SJ, et al., 'Photothrombotic Stroke Induces Persistent Ipsilateral and Contralateral Astrogliosis in Key Cognitive Control Nuclei', Neurochemical Research, (2014) [C1]

While astrocytes are recognised to play a central role in repair processes following stroke, at this stage we do not have a clear understanding of how these cells are engaged duri... [more]

While astrocytes are recognised to play a central role in repair processes following stroke, at this stage we do not have a clear understanding of how these cells are engaged during the chronic recovery phase. Accordingly, the principal aim of this study was to undertake a quantitative multi-regional investigation of astrocytes throughout the recovery process. Specifically, we have induced experimental vascular occlusion using cold-light photothrombotic occlusion of the somatosensory/motor cortex in adult male C57B6 mice. Four weeks following occlusion we collected, processed, and immunolabelled tissue using an antibody directed at the glial fibrillary acidic protein (GFAP), an astrocyte specific cytoskeletal protein marker. We investigated GFAP changes in 13 regions in both the contra- and ipsi-lateral hemispheres from control and occluded animals. Specifically, we examined the infra-limbic (A24a), pre-limbic (A25), anterior cingulate (A32), motor (M1 and M2) cortices, the forceps minor fibre tract, as well the shell of the accumbens, thalamus, cingulate cortex (A29c), hippocampus (CA1-3) and lateral hypothalamus. Tissue from occluded animals was compared against sham treated controls. We have identified that the focal occlusion produced significant astrogliosis (p < 0.05), as defined by a marked elevation in GFAP expression, within all 13 sites assessed within the ipsilateral (lesioned) hemisphere. We further observed significant increases in GFAP expression (p < 0.05) in 9 of the 13 contralesional sites examined. This work underscores that both the ipsilateral and contralesional hemispheres, at sites distal to the infarct, are very active many weeks after the initial occlusion, a finding that potentially has significant implications for understanding and improving the regeneration of the damaged brain.

DOI 10.1007/s11064-014-1487-8
Citations Scopus - 1Web of Science - 1
Co-authors Sarah Johnson
2014 Walker FR, Beynon SB, Jones KA, Zhao Z, Kongsui R, Cairns M, Nilsson M, 'Dynamic structural remodelling of microglia in health and disease: A review of the models, the signals and the mechanisms', BRAIN BEHAVIOR AND IMMUNITY, 37 1-14 (2014) [C1]
DOI 10.1016/j.bbi.2013.12.010
Citations Scopus - 26Web of Science - 18
Co-authors Murray Cairns
2014 Kongsui R, Beynon SB, Johnson SJ, Mayhew J, Kuter P, Nilsson M, Walker FR, 'Chronic stress induces prolonged suppression of the P2X7 receptor within multiple regions of the hippocampus: A cumulative threshold spectra analysis', Brain, Behavior, and Immunity, 42 69-80 (2014) [C1]
DOI 10.1016/j.bbi.2014.05.017
Citations Scopus - 3Web of Science - 1
Co-authors Sarah Johnson
2014 Hollins SL, Goldie BJ, Carroll AP, Mason EA, Walker FR, Eyles DW, Cairns MJ, 'Ontogeny of small RNA in the regulation of mammalian brain development', BMC GENOMICS, 15 (2014) [C1]
DOI 10.1186/1471-2164-15-777
Citations Scopus - 3Web of Science - 3
Co-authors Murray Cairns
2014 Hollins SL, Zavitsanou K, Walker FR, Cairns MJ, 'Alteration of imprinted Dlk1-Dio3 miRNA cluster expression in the entorhinal cortex induced by maternal immune activation and adolescent cannabinoid exposure.', Transl Psychiatry, 4 e452 (2014) [C1]
DOI 10.1038/tp.2014.99
Citations Scopus - 8Web of Science - 3
Co-authors Murray Cairns
2014 James MH, Campbell EJ, Walker FR, Smith DW, Richardson HN, Hodgson DM, Dayas CV, 'Exercise reverses the effects of early life stress on orexin cell reactivity in male but not female rats', Frontiers in Behavioral Neuroscience, 8 (2014) [C1]
DOI 10.3389/fnbeh.2014.00244
Citations Scopus - 4Web of Science - 2
Co-authors Deborah Hodgson, Christopher Dayas, Douglas Smith
2014 Kongsui R, Beynon SB, Johnson SJ, Walker FR, 'Quantitative assessment of microglial morphology and density reveals remarkable consistency in the distribution and morphology of cells within the healthy prefrontal cortex of the rat', JOURNAL OF NEUROINFLAMMATION, 11 (2014) [C1]
DOI 10.1186/s12974-014-0182-7
Citations Web of Science - 1
Co-authors Sarah Johnson
2014 Walker FR, James MH, Hickie IB, McGorry PD, 'Clinical staging: a necessary step in the development of improved animal models of mood disturbance?', Int J Neuropsychopharmacol, 17 491-495 (2014) [C1]
DOI 10.1017/S1461145713001107
Citations Scopus - 1Web of Science - 1
2013 Tynan RJ, Beynon SB, Hinwood M, Johnson SJ, Nilsson M, Woods JJ, Walker FR, 'Chronic stress-induced disruption of the astrocyte network is driven by structural atrophy and not loss of astrocytes', Acta Neuropathologica, 126 75-91 (2013) [C1]
DOI 10.1007/s00401-013-1102-0
Citations Scopus - 24Web of Science - 15
Co-authors Sarah Johnson, Madeleine Hinwood
2013 Walker FR, 'A critical review of the mechanism of action for the selective serotonin reuptake inhibitors: Do these drugs possess anti-inflammatory properties and how relevant is this in the treatment of depression?', NEUROPHARMACOLOGY, 67 304-317 (2013) [C1]
DOI 10.1016/j.neuropharm.2012.10.002
Citations Scopus - 32Web of Science - 23
2013 Hinwood M, Tynan RJ, Charnley JL, Beynon SB, Day TA, Walker FR, 'Chronic Stress Induced Remodeling of the Prefrontal Cortex: Structural Re-Organization of Microglia and the Inhibitory Effect of Minocycline', CEREBRAL CORTEX, 23 1784-1797 (2013) [C1]
DOI 10.1093/cercor/bhs151
Citations Scopus - 35Web of Science - 20
Co-authors Madeleine Hinwood
2013 Walker FR, Nilsson M, Jones K, 'Acute and Chronic Stress-Induced Disturbances of Microglial Plasticity, Phenotype and Function', Current Drug Targets, 14 1262-1276 (2013) [C1]
Citations Scopus - 25Web of Science - 16
2013 Bobrovskaya L, Beard D, Bondarenko E, Beig MI, Jobling P, Walker FR, et al., 'Does exposure to chronic stress influence blood pressure in rats?', AUTONOMIC NEUROSCIENCE-BASIC & CLINICAL, 177 217-223 (2013) [C1]
DOI 10.1016/j.autneu.2013.05.001
Citations Scopus - 6Web of Science - 4
Co-authors Phillip Jobling, Daniel J Beard, Eugene Nalivaiko
2012 Sominsky Bar L, Walker AK, Ong LK, Tynan R, Walker FR, Hodgson DM, 'Increased microglial activation in the rat brain following neonatal exposure to a bacterial mimetic', Behavioural Brain Research, 226 351-356 (2012) [C1]
DOI 10.1016/j.bbr.2011.08.038
Citations Scopus - 23Web of Science - 18
Co-authors Deborah Hodgson, Linkooi Ong
2012 Beynon SB, Walker FR, 'Microglial activation in the injured and healthy brain: What are we really talking about? Practical and theoretical issues associated with the measurement of changes in microglial morphology', Neuroscience, 225 162-171 (2012) [C1]
Citations Scopus - 33Web of Science - 28
2012 Tynan R, Weidenhofer JC, Hinwood M, Cairns MJ, Day TA, Walker FR, 'A comparative examination of the anti-inflammatory effects of SSRI and SNRI antidepressants on LPS stimulated microglia', Brain Behavior and Immunity, 26 469-479 (2012) [C1]
Citations Scopus - 74Web of Science - 56
Co-authors Murray Cairns, Madeleine Hinwood, Judith Weidenhofer
2012 Hinwood M, Morandini J, Day TA, Walker FR, 'Evidence that microglia mediate the neurobiological effects of chronic psychological stress on the medial prefrontal cortex', Cerebral Cortex, 22 1442-1454 (2012) [C1]
Citations Scopus - 102Web of Science - 82
Co-authors Madeleine Hinwood
2012 Barreto RDA, Walker FR, Dunkley PR, Day TA, Smith DW, 'Fluoxetine prevents development of an early stress-related molecular signature in the rat infralimbic medial prefrontal cortex. Implications for depression?', BMC Neuroscience, 13 1-12 (2012) [C1]
Citations Scopus - 12Web of Science - 9
Co-authors Douglas Smith, Peter Dunkley
2011 Beig MI, Callister R, Saint DA, Bondarenko E, Walker FR, Day TA, Nalivaiko E, 'Voluntary exercise does not affect stress-induced tachycardia, but improves resistance to cardiac arrhythmias in rats', Clinical and Experimental Pharmacology and Physiology, 38 19-26 (2011) [C1]
DOI 10.1111/j.1440-1681.2010.05456.x
Citations Scopus - 3Web of Science - 3
Co-authors Eugene Nalivaiko, Robin Callister
2011 Carnevali L, Bondarenko E, Sgoifo A, Walker FR, Head GA, Lukoshkova EV, et al., 'Metyrapone and fluoxetine suppress enduring behavioral but not cardiac effects of subchronic stress in rats', American Journal of Physiology-Regulatory Integrative and Comparative Physiology, 301 R1123-R1131 (2011) [C1]
Citations Scopus - 5Web of Science - 5
Co-authors Eugene Nalivaiko
2011 Ong LK, Bobrovskaya L, Walker FR, Day TA, Dickson PW, Dunkley PR, 'The effect of social defeat on tyrosine hydroxylase phosphorylation in the rat brain and adrenal gland', Neurochemical Research, 36 27-33 (2011) [C1]
DOI 10.1007/s11064-010-0255-7
Citations Scopus - 7Web of Science - 7
Co-authors Peter Dunkley, Phil Dickson, Linkooi Ong
2011 Hinwood M, Tynan R, Day TA, Walker FR, 'Repeated social defeat selectively increases DeltaFosB expression and histone H3 acetylation in the infralimbic medial prefrontal cortex', Cerebral Cortex, 21 262-271 (2011) [C1]
DOI 10.1093/cercor/bhq080
Citations Scopus - 24Web of Science - 15
Co-authors Madeleine Hinwood
2010 Hodyl NA, Walker FR, Krivanek K, Clifton VL, Hodgson DM, 'Prenatal endotoxin exposure alters behavioural pain responses to lipopolysaccharide in adult offspring', Physiology & Behavior, 100 143-147 (2010) [C1]
DOI 10.1016/j.physbeh.2010.02.013
Citations Scopus - 6Web of Science - 7
Co-authors Deborah Hodgson, Vicki Clifton
2010 Kabir MM, Beig MI, Baumert M, Trombini M, Mastorci F, Sgoifo A, et al., 'Respiratory pattern in awake rats: Effects of motor activity and of alerting stimuli', Physiology and Behavior, 101 22-31 (2010) [C1]
DOI 10.1016/j.physbeh.2010.04.004
Citations Scopus - 24Web of Science - 22
Co-authors Eugene Nalivaiko
2010 Mackenzie LJ, Nalivaiko E, Beig MI, Day TA, Walker FR, 'Ability of predator odour exposure to elicit conditioned versus sensitised post traumatic stress disorder-like behaviours, and forebrain dFosB expression, in rats', Neuroscience, 169 733-742 (2010) [C1]
DOI 10.1016/j.neuroscience.2010.05.005
Citations Scopus - 15Web of Science - 14
Co-authors Lisa Mackenzie, Eugene Nalivaiko
2010 Tynan R, Naicker S, Hinwood M, Nalivaiko E, Buller KM, Pow DV, et al., 'Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions', Brain Behavior and Immunity, 24 1058-1068 (2010) [C1]
DOI 10.1016/j.bbi.2010.02.001
Citations Scopus - 107Web of Science - 89
Co-authors Eugene Nalivaiko, Madeleine Hinwood
2009 Walker FR, Hodyl NA, Hodgson DM, 'Neonatal bacterial endotoxin challenge interacts with stress in the adult male rat to modify KLH specific antibody production but not KLH stimulated ex vivo cytokine release', Journal of Neuroimmunology, 207 57-65 (2009) [C1]
DOI 10.1016/j.jneuroim.2008.11.012
Citations Scopus - 17Web of Science - 14
Co-authors Deborah Hodgson
2009 Walker FR, Masters LM, Dielenberg R, Day TA, 'Coping with defeat: Acute glucocorticoid and forebrain responses to social defeat vary with defeat episode behaviour', Neuroscience, 162 244-253 (2009) [C1]
DOI 10.1016/j.neuroscience.2009.04.041
Citations Scopus - 27Web of Science - 25
2009 Beig MI, Baumert M, Walker FR, Day TA, Nalivaiko E, 'Blockade of 5-HT2A receptors suppresses hyperthermic but not cardiovascular responses to psychosocial stress in rats', Neuroscience, 159 1185-1191 (2009) [C1]
DOI 10.1016/j.neuroscience.2009.01.038
Citations Scopus - 5Web of Science - 4
Co-authors Eugene Nalivaiko
2009 Walker FR, Naicker S, Hinwood M, Dunn N, Day TA, 'Strain differences in coping behaviour, novelty seeking behaviour, and susceptibility to socially conditioned fear: A comparison between Wistar and Sprague Dawley rats', Stress: The International Journal on the Biology of Stress, 12 507-516 (2009) [C1]
DOI 10.3109/10253890802673134
Citations Scopus - 9Web of Science - 6
Co-authors Madeleine Hinwood
2008 Walker FR, Knott BG, Hodgson DM, 'Neonatal endotoxin exposure modifies the acoustic startle response and circulating levels of corticosterone in the adult rat but only following acute stress', Journal of Psychiatric Research, 42 1094-1103 (2008) [C1]
DOI 10.1016/j.jpsychires.2007.12.006
Citations Scopus - 28Web of Science - 28
Co-authors Deborah Hodgson
2008 Walker FR, Hinwood M, Masters LM, Dielenberg R, Day TA, 'Individual differences predict susceptibility to conditioned fear arising from psychosocial trauma', Journal of Psychiatric Research, 42 371-383 (2008) [C1]
DOI 10.1016/j.jpsychires.2007.01.007
Citations Scopus - 17Web of Science - 13
Co-authors Madeleine Hinwood
2007 Day TA, Walker FR, 'More appraisal please: A commentary on Pfaff et al. (2007) 'Relations between mechanisms of CNS arousal and mechanisms of stress'', Stress: The International Journal on the Biology of Stress, 10 311-313 (2007) [C1]
DOI 10.1080/10253890701638204
Citations Scopus - 7Web of Science - 9
2007 Hodyl NA, Walker FR, Krivanek K, Clifton VL, Hodgson DM, 'Modelling prenatal bacterial infection: Functional consequences of altered hypothalamic pituitary adrenal axis development', Behavioral Brain Research, 178 108-114 (2007) [C1]
DOI 10.1016/j.bbr.2006.12.008
Citations Scopus - 8Web of Science - 8
Co-authors Deborah Hodgson, Vicki Clifton
2006 Walker FR, Owens J, Ali S, Hodgson DM, 'Individual differences in glucose homeostasis: Do our early life interactions with bacteria matter?', Brain Behavior and Immunity, 20 401-409 (2006) [C1]
DOI 10.1016/j.bbi.2005.11.004
Citations Scopus - 21Web of Science - 18
Co-authors Deborah Hodgson
2006 Walker FR, Hodyl NA, Krivanek K, Hodgson DM, 'Early life host-bacteria relations and development: Long-term individual differences in neuroimmune function following neonatal endotoxin challenge', Physiology & Behavior, 87 126-134 (2006) [C1]
DOI 10.1016/j.physbeh.2005.09.008
Citations Scopus - 34Web of Science - 35
Co-authors Deborah Hodgson
2004 Walker FR, Hodgson DM, 'Interactions between the newborn and the early life microbial environment alter the development of anxiety-like behaviour in the Fischer 344 Rat', Australian Journal of Psychology, 56 232 (2004) [C3]
Co-authors Deborah Hodgson
2004 Walker FR, Brogan AE, Smith R, Hodgson DM, 'A profile of the immediate endocrine, metabolic and behavioural responses following a dual exposure to endotoxin in early life', Physiology & Behavior, 83 495-504 (2004) [C1]
DOI 10.1016/j.physbeh.2004.08.030
Citations Scopus - 20Web of Science - 19
Co-authors Deborah Hodgson, Roger Smith
2004 Walker FR, March JR, Hodgson DM, 'Endotoxin exposure in early life alters the development of anxiety-like behaviour in the Fischer 344 rat', Behavioural Brain Research, 154 63-69 (2004) [C1]
DOI 10.1016/j.bbr.2004.01.019
Citations Scopus - 53Web of Science - 53
Co-authors Deborah Hodgson
2004 Walker FR, Hodyl NA, Hodgson DM, 'The effect of postnatal endotoxin exposure on nociception in adulthood: hyper-analgesia following immune challenge', Brain, Behavior, and Immunity, 18 CD (2004) [C3]
Co-authors Deborah Hodgson
2004 Hodyl NA, Walker FR, Mears CEP, Hume KA, Hodgson DM, 'Prenatal exposure to endotoxin in the Fischer 344 rat: consequences for neuroendocrine and immune function, and nocieptive thresholds in the offspring', Brian, Behavior, and Immunity, 18 CD (2004) [C3]
Co-authors Deborah Hodgson
2003 Hodyl NA, Walker FR, Hodgson DM, 'Prenatal exposure to bacteria alters foetal hypothalamic-pituitary-adrenal development', Australian Journal of Psychology, 55 215 (2003) [C3]
Co-authors Deborah Hodgson
2001 Hodgson DM, Knott BG, Walker FR, 'Neonatal Endotoxin Exposure Influences HPA Responsivity and Impairs Tumour Immunity in Fischer 344 Rats in Adulthood', Pediatric Research, 50:6 750-755 (2001) [C1]
Citations Scopus - 67Web of Science - 69
Co-authors Deborah Hodgson
Show 52 more journal articles

Conference (44 outputs)

Year Citation Altmetrics Link
2015 Walker FR, 'Improvement of classical methods and development of high throughput automated methods for the analysis of glial morphology', GLIA (2015) [E3]
2015 Walker FR, 'Chronic stress exacerbates neuronal loss associated with secondary neurodegeneration and suppresses microglial-like cells following focal motor cortex ischemia in the mouse', JOURNAL OF NEUROCHEMISTRY (2015) [E3]
2015 Walker FR, Jones K, Zouikr I, Patience M, Clarkson A, Isgaard J, et al., 'Understanding "Stress X Microglial interactions" in stroke-induced secondary neurodegeneration: a major opportunity for the preser', JOURNAL OF NEUROCHEMISTRY (2015) [E3]
Co-authors Neil Spratt
2015 Walker FR, Zouikr I, Patience M, Clarkson A, Isgaard J, Johnson S, et al., 'Chronic stress exacerbates neuronal loss associated with secondary neurodegeneration and suppresses microglial-like cells following focal motor cortex ischemia in the mouse', GLIA (2015) [E3]
Co-authors Sarah Johnson, Neil Spratt
2015 Turley JA, Nilsson M, Walker FR, Johnson SJ, 'A comparison of signal processing techniques for Intrinsic Optical Signal imaging in mice', Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS (2015) [E1]

© 2015 IEEE. Intrinsic Optical Signal imaging is a technique which allows the visualisation and mapping of activity related changes within the brain with excellent spatial and te... [more]

© 2015 IEEE. Intrinsic Optical Signal imaging is a technique which allows the visualisation and mapping of activity related changes within the brain with excellent spatial and temporal resolution. We analysed a variety of signal and image processing techniques applied to real mouse imaging data. The results were compared in an attempt to overcome the unique issues faced when performing the technique on mice and improve the understanding of post processing options available.

DOI 10.1109/EMBC.2015.7319828
Co-authors Sarah Johnson
2013 Tynan R, Beynon S, Nilsson M, Walker F, 'CHRONIC STRESS INDUCES PROFOUND STRUCTURAL REMODELLING OF ASTROCYTES WITHIN THEPREFRONTAL CORTEX: A CHARACTERIZATION OF THE RELATIONSHIP BETWEEN ASTROCYTE MORPHOLOGYAND DENSITY', GLIA (2013) [E3]
2012 Walker FR, 'The role of microglia in the regulation of mood state and cognitive function', Abstracts of the 21st Annual Meeting of the International Behavioral Neuroscience Society (2012) [E3]
2012 Walker FR, Tynan R, Day TA, 'More than just reuptake inhibitors: A comparative examination of the antiinflammatory effects of SSRI and SNRI antidepressants on microglia', Abstracts. Australian Neuroscience Society 32nd Annual Meeting (2012) [E3]
2012 Walker FR, Tynan R, Hinwood M, Woodworth SB, 'The role of microglia in cognitive disturbance: A new frontier in the neurobiology of stress', Brain, Behavior, and Immunity (2012) [E3]
Co-authors Madeleine Hinwood
2011 Sominsky Bar L, Walker AK, Ong LK, Tynan R, Walker FR, Hodgson DM, 'Epigenetic inheritance of anxiety-like behaviour in rats - Role of early life exposure to a bacterial mimetic', Journal of Developmental Origins of Health and Disease (2011) [E3]
Co-authors Linkooi Ong, Deborah Hodgson
2011 Carnevali L, Bondarenko E, Sgoifo A, Walker FR, Day TA, Nalivaiko E, 'Fluoxetine and metyrapone block behavioural but not cardiac effects of subchronic stress', Oral abstracts. Australian Neuroscience Society Annual Meeting (2011) [E3]
Co-authors Eugene Nalivaiko
2011 Bondarenko E, Carnevali L, McPherson AE, Walker FR, Day TA, Hodgson DM, Nalivaiko E, 'Respiratory, but not cardiac, responses to acoustic stimulation are attenuated by diazepam pre-treatment: A novel index of anxiety in rats', Oral abstracts. Australian Neuroscience Society Annual Meeting (2011) [E3]
Co-authors Eugene Nalivaiko, Deborah Hodgson
2011 Barreto RDA, Walker FR, Dunkley PR, Day TA, Smith DW, 'Alteration of neurotrophic factor pathway gene expression in the rat infralimbic medial prefrontal cortex by subchronic restraint stress is reversed by fluoxetine', Posters. Australian Neuroscience Society 31st Annual Meeting (2011) [E3]
Co-authors Douglas Smith, Peter Dunkley
2011 Walker FR, Tynan R, Day TA, Ng A, Hinwood M, 'What have microglia got to do with it? New directions in the neurobiology of depression', Brain, Behavior, and Immunity (2011) [E3]
Co-authors Madeleine Hinwood
2011 Nalivaiko E, Carnevali L, Bondarenko E, Sgoifo A, Walker FR, Day TA, 'Metyrapone and fluoxetine suppress behavioural but not cardiac effects of sub-chronic stress in rats', FASEB JOURNAL (2011) [E3]
Co-authors Eugene Nalivaiko
2011 Tynan RJ, Day TA, Brichta AM, Walker FR, 'Not Just Reuptake. Selective serotonin reuptake inhibitors attenuate LPS induced microglial pro-inflammatory cytokine production', Society of Neuroscience (2011) [E3]
Co-authors Alan Brichta
2010 Walker FR, 'The role of microglia in the regulation of mood state: Implications for depression', Proceedings of the Australasian Society for Psychiatric Research (ASPR) 2010 Conference (2010) [E3]
2010 Nalivaiko E, Beard D, Bondarenko E, Beig MI, Jobling P, Walker FR, et al., 'CHRONIC FOOTSHOCK STRESS CAUSES ENDURING CHANGES IN CIRCADIAN RHYTHMS, WITHOUT PROVOKING HYPERTENSION IN RATS', FASEB JOURNAL (2010) [E3]
Co-authors Phillip Jobling, Eugene Nalivaiko
2009 Tynan R, Naicker S, Day TA, Walker FR, 'The impact of chronic restraint stress on regulating behavioural and glial changes in the adult rat', ANS 2009 Abstracts: Posters (2009) [E3]
2009 Ong LK, Bobrovskaya L, Walker FR, Day TA, Dickson PW, Dunkley PR, 'The effect of social conflict on tyrosine hydroxylase phosphorylation in catecholamine-producing cells from sprague-dawley rats', Journal of Neurochemistry (2009) [E3]
DOI 10.1111/j.1471-4159.2009.06242.x
Co-authors Phil Dickson, Peter Dunkley, Linkooi Ong
2007 Hinwood M, Walker FR, Day TA, 'Characterisation of fosB response in rat forebrain following exposure to chronic social stress (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program (2007) [E3]
Co-authors Madeleine Hinwood
2007 Masters LM, Walker FR, Dielenberg R, Day TA, 'Psychosocial stress: individual differences in coping behaviour, hpa axis activation and limbic system activation patterns (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program (2007) [E3]
2007 Walker FR, Hinwood M, Masters LM, Dielenberg R, Day TA, 'Individual differences predict susceptibility to conditioned fear arising from psychosocial trauma (Poster)', 7th IBRO 2007 World Congress of Neuroscience Program (2007) [E3]
Co-authors Madeleine Hinwood
2006 Walker FR, Masters LM, Dielenberg R, Day TA, 'Individual differences in coping strategy predict glucocorticoid responses to psychosocial stress', Proceedings of the Australian Neuroscience Society (2006) [E3]
2005 Beck AK, Hodyl NA, Krivanek K, Knott BG, Walker FR, Hodgson DM, 'Impact of Neonatal Endotoxin Exposure on Nociception in the F344 Rat: A Developmental Perspective', Australian Neuroscience Society: Proceedings of the 25th Annual "Silver Jubilee" Meeting (2005) [E3]
Co-authors Deborah Hodgson
2005 Hodyl NA, Krivanek K, Walker FR, Feltis BB, Hodgson DM, 'A Developmental Profile of the Effects of Prenatal Endotoxin Exposure on Neuroendocrine and Immune Function', Australian Neuroscience Society: Proceedings of the 25th Annual "Silver Jubilee" Meeting (2005) [E3]
Co-authors Deborah Hodgson
2005 Krivanek K, Hodyl NA, Walker FR, Hodgson DM, 'Maternal and Foetal Immune and Neuroendocrine Response to Type 1 and Type 2 Immune Stimuli', "Before and Beyond Birth" Perinatal Society of Australia and New Zealand 9th Annual Congress (2005) [E3]
Co-authors Deborah Hodgson
2005 Hodyl NA, Krivanek K, Walker FR, Hodgson DM, 'Neuroendocrine, Immune and Nociceptive Responses in Offspring Exposed to an Immune Challenge Prenatally', "Before and Beyond Birth" Perinatal Society of Australia and New Zealand 9th Annual Congress (2005) [E3]
Co-authors Deborah Hodgson
2005 Knott BG, Walker FR, Hodgson DM, 'Postnatal Bacterial Infection as a Predictor of Post Traumatic Stress Disorder: Physiological and Behavioural Correlates in the Rodent', Pediatric Research: Placenta and Intrauterine Growth, V58(5) suppl: Proceedings of 3rd International Congress on Developmental Origins of Health & Disease (2005) [E3]
Co-authors Deborah Hodgson
2003 Walker FR, Brogan AE, Hodgson DM, 'Neonatal endotoxin exposure alters mother-pup interactions and is associated with anxiety-like behaviour in adulthood', Brain Behaviour, and Immunity (2003) [E3]
Co-authors Deborah Hodgson
2003 Hodgson DM, Mears CEP, Walker FR, 'Impact of immune activation during pregnancy on offspring's endocrine and immune responses in adulthood', Brain, Behavior, and Immunity (2003) [E3]
Co-authors Deborah Hodgson
2003 Hodgson DM, Mears CEP, Walker FR, 'Immune activation during pregnancy alters offspring's endocrine and immune responses in adulthood', Pediatric Research (2003) [E3]
Co-authors Deborah Hodgson
2003 Walker FR, Hodgson DM, 'Neonatal endotoxin exposure alters metabolic and immune responses in adulthood', Pediatric Research (2003) [E3]
Co-authors Deborah Hodgson
2003 Hodyl NA, Walker FR, Owens J, Hodgson DM, 'Exposure to a Bacterial Infection During Pregancy alters Fetal Development with Consequences for Glucose Metabolism', The Endocrine Society of Australia Proceedings 2003 (2003) [E3]
Co-authors Deborah Hodgson
2003 Walker FR, Hodyl NA, Hodgson DM, 'Neonatal Bacterial Endotoxin Exposure Alters Glucose Metabolism, Leptin Production and Body Mass Index Across Development in the Fischer 344 Rat', The Endocrine Society of Australia Proceedings 2003 (2003) [E3]
Co-authors Deborah Hodgson
2002 Hodyl NA, Walker FR, Hodgson DM, 'Prenatal endotoxin exposure reduces stress response of pre-weaned guinea pigs in sex-specific manner', Conference Supplements : The Endocrine Society of Australia (2002) [E3]
Co-authors Deborah Hodgson
2002 Hodgson DM, Hodyl NA, Walker FR, 'Neuroendocrine programming of cancer: the role of pre natal and postnatal physiological stressors', Conference supplements: The Endocrine Society of Australia (2002) [E3]
Co-authors Deborah Hodgson
2002 Hodgson DM, March JR, Walker FR, 'Neonatal Exposure to Bacterial Endotoxin is Associated with Increased Anxiety-Related Behavior and Altered Metabolic Responsivity in Adulthood', Brain, Behavior, and Immunity vol 16, no.2, April 2002 (2002) [E3]
Co-authors Deborah Hodgson
2002 Hodgson DM, Brown A, Walker FR, 'Exposure to bacterial endotoxin in early life alters immunological responsivity in adulthood', Brain, Behavior, and Immunity vol 16, no.2, April 2002 (2002) [E3]
Co-authors Deborah Hodgson
2002 Walker FR, Hodgson DM, 'Neonatal Bacterial endotoxin exposure alters pro-inflammatory and febrile responses in adult rodents', The Endocrine Society of Australia (2002) [E3]
Co-authors Deborah Hodgson
2001 Hodgson DM, Knott BG, Walker FR, Allen T, 'Neonatal Stress Potentiates HPA Activity and Enhances Tumor Metastasis in Adult Rodents', The Endocrine Society of Australia: Proceedings 2001 (2001) [E3]
Co-authors Deborah Hodgson
2000 Hodgson DM, Rosengren SM, Walker FR, 'Neonatal stress potentiates hypothalmic-pituitary-adrenal (HPA) responsivity and impairs wound healing and tumor resistance in the adult rat', Brain Behavior and Immunity (2000) [E3]
Co-authors Deborah Hodgson
2000 Hodgson DM, Rosengren SM, Walker FR, 'Exposure to neonatal stress potentiates hypothalmic-pituitary-adrenal (HPA) responsivity and impairs tumor immunity and wound healing in the adult rat', International Journal of Behavioural Medicine (2000) [E3]
Co-authors Deborah Hodgson
2000 Hodgson DM, Rosengren SM, Walker FR, 'Neonatal stress exposure impairs wound healing and tumor immunity in the adult rat', Psychoneuroendocronology (2000) [E3]
Co-authors Deborah Hodgson
Show 41 more conferences
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Grants and Funding

Summary

Number of grants 24
Total funding $2,259,626

Click on a grant title below to expand the full details for that specific grant.


20161 grants / $20,000

Development and implementation of improved monitoring of psychological stress loads in patients recovering from stroke$20,000

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Conjoint Associate Professor Michael Pollack, Professor Michael Nilsson, Doctor Frederick Walker, Doctor Lin Kooi Ong
Scheme Research Grant
Role Investigator
Funding Start 2016
Funding Finish 2017
GNo G1600724
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20153 grants / $47,000

Maintaining our cognitive abilities as we grow old: preventing the effects of ageing on the brain$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Doug Smith, Doctor Frederick Walker
Scheme Project Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1500078
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Blocking the negative effects of stress on the brain to promote better healing of the brain after stroke$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Frederick Walker, Doctor Lin Kooi Ong, Doctor Ming Yang, Associate Professor Sarah Johnson
Scheme Project Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1501384
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

International Society for Psychoneuroimmunology, Seattle US, 3-6 June 2015$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Frederick Walker
Scheme Travel Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1500726
Type Of Funding Internal
Category INTE
UON Y

20144 grants / $1,187,330

Modelling schizophrenia-associated changes in mir-137 expression$567,044

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Associate Professor Murray Cairns, Doctor Frederick Walker
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2017
GNo G1300360
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Microglia as primary drivers of stress-induced changes in neuronal connectivity$460,037

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Frederick Walker, Associate Professor Brett Graham
Scheme Project Grant
Role Lead
Funding Start 2014
Funding Finish 2016
GNo G1300330
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Investigating the neuroprotective effects of growth hormone$110,750

Funding body: University of Gothenburg

Funding body University of Gothenburg
Project Team Doctor Frederick Walker, Professor Michael Nilsson, Professor Jorgen Isgaard
Scheme Research Grant
Role Lead
Funding Start 2014
Funding Finish 2016
GNo G1301437
Type Of Funding International - Non Competitive
Category 3IFB
UON Y

CATCH IT: Developing a safe and ultra-reliable measure of chronic stress to prevent stress-related complications in recovery from stroke$49,499

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Frederick Walker
Scheme Project Grant
Role Lead
Funding Start 2014
Funding Finish 2016
GNo G1500634
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20135 grants / $110,000

Functional characterisation of schizophrenia-associated neurodevelopmental dysfunction of miR-137$25,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Associate Professor Murray Cairns, Doctor Frederick Walker, Professor Alan Brichta, Doctor Natalie Beveridge
Scheme Near Miss Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300468
Type Of Funding Internal
Category INTE
UON Y

Functional characterisation of schizophrenia-associated neurodevelopmental dysfunction of miR-137$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Associate Professor Murray Cairns, Doctor Frederick Walker, Professor Alan Brichta, Doctor Natalie Beveridge
Scheme Near Miss
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300801
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

microRNA and translation dynamics of synaptic plasticity$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Associate Professor Murray Cairns, Professor Alan Brichta, Doctor Frederick Walker
Scheme Near Miss Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1300463
Type Of Funding Internal
Category INTE
UON Y

Understanding the role of microglia in stress-induced changes in neuronal connectivity$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Frederick Walker
Scheme Near Miss Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300486
Type Of Funding Internal
Category INTE
UON Y

Understanding the role of microglia in stress-induced changes in neuronal connectivity$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Frederick Walker
Scheme Near Miss
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300799
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20121 grants / $15,000

2011 Emerging Research Leaders Program$15,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Frederick Walker
Scheme Emerging Research Leaders Program
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200470
Type Of Funding Internal
Category INTE
UON Y

20115 grants / $482,296

A new target for antidepressant treatment: microglia mediated neuroinflammation$346,980

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Frederick Walker
Scheme Project Grant
Role Lead
Funding Start 2011
Funding Finish 2013
GNo G1000245
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

2007 Research Fellowship$108,316

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Frederick Walker
Scheme Postdoctoral Research Fellowship
Role Lead
Funding Start 2011
Funding Finish 2012
GNo G1000609
Type Of Funding Internal
Category INTE
UON Y

Establishing the effectiveness of anti-neuroinflammatory agents in the fight against depression$15,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Frederick Walker, Professor Trevor Day
Scheme Project Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1001007
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

IMPLEN NanoPhotometer pearl$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Professor Alan Brichta, Emeritus Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Professor Ulli Schall, Associate Professor Phillip Dickson, Doctor Frederick Walker, Doctor Rick Thorne, Associate Professor Chris Dayas, Doctor Nikki Verrills, Doctor Janet Bristow, Doctor Severine Roselli, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Associate Professor Liz Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Dr DAN Johnstone, Ms BELINDA Goldie, Doctor Natalie Beveridge
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100030
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Annual Psychoneuroimmunology Research Society Meeting, Hilton Indian Lakes Resort, Chicago, Illnois, 7 - 12 June 2011$2,000

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Frederick Walker
Scheme Travel Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1100430
Type Of Funding Internal
Category INTE
UON Y

20102 grants / $84,000

Targeting neuroinflammation to improve the efficacy of antidepressant drugs$50,000

Funding body: BellBerry Limited

Funding body BellBerry Limited
Project Team Doctor Frederick Walker, Dr Kathryn Buller, Associate Professor Paul Tooney
Scheme Near Miss
Role Lead
Funding Start 2010
Funding Finish 2012
GNo G0900219
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

ABI 7500 Real Time PCR System $34,000

Funding body: NHMRC (National Health & Medical Research Council)

20082 grants / $40,000

A novel approach to developing new treatments for anxiety: Identification of neural pathways underlying resistance and susceptibility to anxiety disorders.$25,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Frederick Walker
Scheme Project Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188476
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

2007 Research Fellowship Project grant $15,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Frederick Walker
Scheme Research Fellowship
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0187128
Type Of Funding Internal
Category INTE
UON Y

20071 grants / $274,000

New treatments for depression: Identification of neural pathways underlying resistance and susceptibility to depression$274,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Frederick Walker
Scheme Training (Postdoctoral) Fellowships - Peter Doherty Biomedical Fellowship (Australia)
Role Lead
Funding Start 2007
Funding Finish 2010
GNo G0186786
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y
Edit

Research Supervision

Number of supervisions

Completed2
Current15

Total current UON EFTSL

Masters0.5
PhD5.25

Current Supervision

Commenced Level of Study Research Title / Program / Supervisor Type
2016 PhD Investigating Mechanisms of Post-Transcriptional Regulation of Neuronal Translation
PhD (Medical Genetics), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2015 PhD Application of Image Processing in Glial Cell Microscopy Image Analysis
PhD (Electrical Engineering), Faculty of Engineering and Built Environment, The University of Newcastle
Co-Supervisor
2014 PhD Investigating changes in cerebrospinal fluid dynamics as a potential cause for intracranial pressure elevation after stroke
PhD (Human Physiology), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2014 Masters The Design and Construction of an Intrinsic Optical Signal Brain Imaging System Combined with a Virtual Reality Setup to Investigate the Effects of Stroke in Mice
M Philosophy(Elec Engineering), Faculty of Engineering and Built Environment, The University of Newcastle
Co-Supervisor
2014 PhD Examining the Role of Stress, Glia and Cognitive Function
PhD (Anatomy), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD Development of an Intrinsic Optical Signal Imaging Pipeline to Investigate Cortical Re-organisation Following Experimental Stroke
PhD (Anatomy), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2014 PhD Environmental determinants of microglial motility
PhD (Anatomy), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2013 PhD Characterizing Changes in the Orexin System in Models of Neuropsychiatric Disease
PhD (Anatomy), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2013 PhD The Effect of Chronic Stress on Stroke Recovery
PhD (Anatomy), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2013 PhD Environmental Enrichment to Improve Outcome After Stroke - What are the Key Contributory Factors?
PhD (Anatomy), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2012 PhD The Role of Autoantibodies in the Development of Depression
PhD (CommunityMed & ClinEpid), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2011 PhD An Examination of How Environmental Disturbances Alter Microglia Morphology and Function Within the CNS
PhD (Human Physiology), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2011 PhD The Role of miRNA and Post-Transcriptional Gene Silencing in Mediating the Mammalian Brains Response to Environmental Stress During Development and Ageing
PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2007 PhD Role of dopamine in the medial pre-frontal cortex
Medical Science, University of Newcastle
Co-Supervisor
2007 Honours Individual differences in susceptibility to fear related pathology
Psychology, University of Newcastle
Sole Supervisor

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2014 PhD The Impact of Stress on Glia: A Characterisation of the Chronic Stress-Induced Density and Morphological Alterations Observed in Astrocytes and Microglia
PhD (Anatomy), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2013 PhD Neurobiological Alterations in the Rat Medial Prefrontal Cortex following Exposure to Chronic Psychological Stress
PhD (Anatomy), Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
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Research Collaborations

The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.

Country Count of Publications
Australia 67
New Zealand 4
United States 4
Italy 3
Sweden 3
More...
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News

World-first stroke trial led by UON researchers

World-first stroke trial led by University of Newcastle researchers underway in the Hunter

February 15, 2016

Stroke survivors who sit for long periods throughout the day could improve their health simply by performing short but frequent bouts of light physical activity.

Rohan Walker

neuroscientist awarded

November 12, 2013

Hunter Medical Research Institute neuroscientist Dr Rohan Walker was named the Newcastle Business Club's Young Business Person of the Year this afternoon, edging out fellow HMRI researcher Dr Luke Wolfenden and federal Liberal candidate Jaimie Abbott.

Dr Frederick Walker

Position

Associate Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Anatomy

Contact Details

Email rohan.walker@newcastle.edu.au
Phone (02) 4921 5012
Fax (02) 4921 5141

Office

Room MSB306 OR Level 3 EAST HMRI
Building Medical Sciences
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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