The clinical toxicology research group focusses on improving understanding of poisoning and envenoming in patients and undertaking studies to determine the effe

CLINICAL TOXICOLOGY
Research Group

Australian Snakebite Project (ASP)

Snake bites are not common in Australia, but cause severe effects and often occur in rural and regional parts of Australia. Antivenoms exist for the treatment of many of these bites and have been used for decades. However, there are still many questions about the effects of different snake venoms and toxins, the effectiveness of antivenom and other treatments, the safety of antivenom and  the exact amount of antivenom that is required for treatment.

ASP is a multicentre study that recruits snakebite cases from all over Australia, collecting clinical information, laboratory investigations and blood samples in all cases. The study measures venom and antivenom concentrations in every patient. The major aim of the study is to better define the clinical and laboratory effects of envenoming by different Australian snakes and the effect of antivenom on these as well as on venom measurements. In addition, a number of interventional studies are included in ASP (see below).

A Randomised Controlled Trial of Antivenom for Red-Bellied Black Snake Envenoming (RBBS)

The purpose of this project is to investigate the effectiveness and safety of early antivenom administration for the treatment of red-bellied black snake bites/envenoming. Red-bellied black snakebites are the most common in Eastern Australia and are not routinely treated with antivenom because they appear to cause minor effects and there is concern about the risk of allergic reactions to antivenom. However, recent work by the ASP investigators suggests that the early use of antivenom will reduce the chance of people developing muscle damage. This study is a randomised controlled trial of one vial of tiger snake antivenom compared to standard care (placebo) and this will provide evidence for or against the early administration of antivenom for muscle damage. The study will also investigate whether antivenom neutralises other effects of RBBS envenoming and determine the frequency of allergic reactions, including anaphylaxis, after antivenom use. In addition to the benefits for Australian snakebite treatment, the results will have global implications because there remains little evidence based on controlled trials for the effectiveness of snake antivenom in general and in particular for muscle damage.