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Dr Katie Baines

Post-Doctoral Research Fellow

School of Medicine and Public Health

Untangling the web of asthma

Research Fellow Dr Katie Baines is identifying biomarkers and targeting neutrophil extracellular traps with the aim of alleviating severe asthma.

“I work in biomarkers and mechanisms of neutrophilic asthma,” Katie says.

Her research has led to a number of important contributions to the knowledge base particularly the role of neutrophils and gene expression in asthma and chronic obstructive pulmonary disease (COPD).

A major project looking at neutrophilic extracellular traps is about to begin.

Katie is also developing a panel of genes to diagnose and medicate for difference types of asthma, as symptoms can be very similar although caused by different underlying mechanisms.

“We are doing a lot of work to further the six gene biomarkers panel, which show the type of inflammation, obviously with the aim of creating a diagnostic tool,” Katie notes.

“In respiratory research I can explore lab based genetic aspects, but also have access to clinical samples and work on human research. I feel I can have a direct impact on patients by helping improve their health.”

Inflammation and asthma

Australia has one of the highest rates of asthma in the world, and traditional treatments are not universally efficacious.

‘There are different types of asthma and they are driven by different types of inflammation,’ Katie states.

The most common form of asthma is caused by eosinophils, white blood cells created by the immune system to address allergies.

“But at least half of people with asthma do not have these cells in their airways,” Katie says.

Instead, neutrophils, another type of white blood cell created by the immune system, are released into the blood, and find their way to the lungs. When eosinophils or neutrophils become over active or accumulate, they create inflammation in the very area they are trying to protect.

Eosinophilic asthma responds to traditional asthma treatments such as short-acting β2 agonists relievers, and corticosteroid preventers.

Unfortunately, neutrophilic asthma is less responsive to these medications.

“So currently, a patient needs higher and higher doses although it is not working as well as it should.”

“We want to change that.”

Neutrophil extracellular traps

Katie believes that studying neutrophils is the key to better treatment for neutrophilic asthma.

“There are no optimised treatments for neutrophilic asthmatics because we don't know much about the mechanism of neutrophilic inflammation.”

Neutrophils release a meshwork of fibers in a web-like trap called neutrophil extracellular traps (NETs), which are made of the cells’ DNA and other proteins that fight infection.

“These webs are a good thing, they are catching the bugs and doing their job,” Katie says.

“But when they get uncontrolled or they accumulate too much, they can be so inflammatory, and make your mucus really thick and sticky. That would stop you clearing your infection.”

Accordingly, Katie is currently working on a theory that targeting NETs could reduce inflammation in severe asthma.

Pulmozyme, a medication currently used to reduce viscosity of mucus in cystic fibrosis sufferers, will be trialed by Katie to test its ability to breakdown the DNA backbone of NETs.

The magic six biomarkers

Originally a molecular biologist, Katie has worked solidly on identifying gene expression biomarkers. By measuring the activity of a panel of six genes, she can pinpoint what type of inflammation a patient has.

“If for example you had eosinophilic inflammation, three of the genes would be high, and the other ones would be low. But if you have neutrophilic inflammation, the other three will be high. And if you have both, well all genes will be high.”

“By having this panel, we are hoping to be able to say, okay, you've got this type of inflammation, and this treatment will work best for you,” Katie says.

“So we’re making treatment more personalised, and thereby more effective.”

Early Success

Katie studied Biomedical Science at the University of Newcastle, as she always had an interest in how the body works and how it is affected in disease.

As an early career researcher, the significance of Katie’s work has been quickly recognised. Throughout her PhD, she received support from The Asthma Foundation of NSW and The Cooperative Research Centre (CRC) for Asthma and Airways.

Since graduating, she has received research fellowships from the Thoracic Society of Australia and New Zealand, National Asthma Council, Xstrata Coal as well as the Australian Lung Foundation.

Katie is co-supervising eight students and is committed to providing a supportive environment for students to grow and learn the skills that will allow them to be successful in their independent research in the future.

Collaborating with others in the field is a priority, and thus Katie is a principal researcher at UON’s Priority Research Centre for Healthy Lungs. Katie also leads a molecular mechanisms group within VIVA (Viruses, Infections/Immunity, Vaccines and Asthma) at HMRI.

Untangling the web of asthma

Katie is a laboratory based researcher with expertise in many methods, including using molecular techniques to address respiratory disease.

Read more

Career Summary

Biography

Dr Baines is a post doctoral researcher in the Department of Respiratory and Sleep Medicine, Hunter Medical Research Institute, and the Priority Research Centre for Asthma and Respiratory Disease. Her second 3 year post-doctoral fellowship commenced in January 2012 through The University of Newcastle, and prior to this she received a research fellowship through (2008-11) funded through Xstrata Coal and HMRI. As an early career post doctoral researcher; Dr Baines manages a semi independent molecular mechanisms group within Professor Peter Gibson’s laboratory. Dr Baines interest in respiratory medicine began when she commenced PhD studies in late 2003 (awarded in 2008), on molecular mechanisms involved in the pathogenesis of noneosinophilic asthma, particularly involving neutrophils. Throughout her PhD she was supported with scholarships from The Asthma Foundation of NSW and the Asthma CRC. Dr Baines is committed to furthering a full-time career in medical research. Her research interests surround the role of gene-environment interactions in the development and pathogenesis of respiratory diseases including asthma and COPD. Dr Baines research uses high throughput genomics technologies to understand more about molecular mechanisms, particularly phenotype definition, biomarker identification and the relationship of phenotypes to clinical outcomes and treatment responses. She is also interested in how respiratory disease phenotypes evolve over time, with regard to the impact of medication use such as inhaled corticosteroids and macrolides, and environmental exposures such as diet and microbial infection. Dr Baines research has led to a number of important contributions to the knowledge base particularly the role of neutrophils and gene expression in asthma and COPD. She has shown that airway neutrophils have an impaired innate immune response in asthma; however blood neutrophils are activated in the neutrophilic phenotype of asthma which is associated with systemic inflammation, a key feature of this phenotype. Dr Baines has defined transcriptional phenotypes of asthma using gene expression profiling of induced sputum and blood, proving the existence of phenotypes as well as the involvement of specific pathways (IL1 and TNF) in the pathogenesis of neutrophilic airway inflammation. Dr Baines has recently identified novel immune genes that are associated with rhinovirus infection of airway epithelial cells in COPD. Since 2009 Dr Baines has published >15 journal articles in highly ranked journals (Thorax, ERJ, JACI), that have been cited 138 times at present. She also has 2 book chapters, 1 Australian Provisional Patent and >38 conference abstracts. Dr Baines has obtained several awards, including the New and Emerging Researcher Awards in 2011 from the Australian Lung Foundation and the Thoracic Society of Australia and New Zealand. She has been awarded 7 competitive travel grant awards, including the esteemed Janet Elder Travel Grant in 2011 and the HMRI Pulse Education Prize in 2010. Dr Baines currently co-supervises 3 PhD students, and was primary supervisor to an honours student who received Class 1 honours in 2012. She is committed to providing a supportive environment for students to grow and learn the skills that will allow them to be successful in their independent research in the future.

Research Expertise

Katie is a laboratory based researcher with expertise in many laboratory methods, including using molecular techniques to understand more about the pathogenesis of respiratory diseases, including asthma and chronic obstructive pulmonary disease (COPD). She has particularl interest in using transcriptomics to understand how environmental influences in predisposed individuals can lead to the development of respiratory disease and different phenotypes of disease. She is also particularly interested in the role of inflammatory cells especially neutrophils in asthma and COPD, and the effects of environmental exposures including medications, diet and infection.

Collaborations
Dr Baines is involved in several successful collaborations, both locally and nationally. 1. Prof Anne Chang, Menzies School of Health and University of Queensland: A new multi-site study investigating airway and systemic markers and mechanisms of Protracted Bacterial Bronchitis in children. Subject of an NHMRC funded grant 2013-2016 2. Dr Manuel Ferreira, University of Queensland: Characterisation of the asthma transcriptome using RNA-seq. Subject of a UQ Collaborative Seed Funding Grant 2012. 3. Dr Brian Oliver and Prof Dominik Hartl, Woolcock Research Institute, University of Sydney, and University of Tubingen, Germany. Neutrophil responses to rhinovirus infection in asthma. Subject of a pending NHMRC grant for 2014. Local collaborations: 1. Prof Peter Gibson and Dr Jodie Simpson: Markers and Mechanisms of severe asthma inflammatory phenotypes. Subject of a NHMRC grant 2013-2015. 2. Dr Vanessa McDonald and Prof Peter Gibson: Phenotype based management of severe asthma. Funded by HMRI and John Hunter Hospital Charitable Trust 2012. 2. Dr Lisa Wood: Effects of diet, including antioxidant withdrawal and fatty acids on gene expression in asthma. 3. A/Prof Peter Wark: Rhinovirus infection and changes in gene expression in primary bronchial epithelial cells in COPD and asthma.

Qualifications

  • PhD, University of Newcastle
  • Bachelor of Biomedical Sciences, University of Newcastle
  • Bachelor of Biomedical Sciences (Hons), University of Newcastle

Keywords

  • Asthma
  • COPD
  • Epigenetics
  • Gene Expression
  • Inflammation
  • Innate Immunity
  • Neutrophils

Fields of Research

Code Description Percentage
110203 Respiratory Diseases 100

Professional Experience

UON Appointment

Title Organisation / Department
Post-Doctoral Research Fellow University of Newcastle
School of Medicine and Public Health
Australia

Academic appointment

Dates Title Organisation / Department
1/01/2015 -  Fellow UON

UoN Research Fellowship

University of Newcastle
School of Medicine and Public Health
Australia
1/01/2012 -  Post Doctoral Research Fellow University of Newcastle
School of Medicine and Public Health
Australia
1/05/2008 - 1/12/2011 Post Doctoral Fellow University of Newcastle
School of Medicine and Public Health
Australia
1/04/2008 - 1/04/2011 Fellow

Hunter Medical Research Institute:- Project Grant

University of Newcastle
School of Medicine and Public Health
Australia
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Grants and Funding

Summary

Number of grants 41
Total funding $3,308,359

Click on a grant title below to expand the full details for that specific grant.


20174 grants / $669,463

Targeting neutrophil extracellular traps to reduce inflammation in severe asthma$590,463

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Katie Baines, Conjoint Professor Peter Gibson, Professor Jodie Simpson, Professor Dominik Hartl, Professor Vanessa McDonald
Scheme Project Grant
Role Lead
Funding Start 2017
Funding Finish 2019
GNo G1500231
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

UON 2017 Researcher Equipment Grant $50,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Katie Baines
Scheme Researcher Equipment Grants
Role Lead
Funding Start 2017
Funding Finish 2017
GNo G1701163
Type Of Funding Internal
Category INTE
UON Y

Extracellular DNA in pleural fluid as a determinant of empyema pathology and treatment response$20,000

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Scott Twaddell, Doctor Katie Baines
Scheme Research Grant
Role Investigator
Funding Start 2017
Funding Finish 2017
GNo G1700745
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

CoreScan Software - Dual Energy X-ray absorptiometry machine$9,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Bronwyn Berthon, Professor Lisa Wood, Doctor Katie Baines, Professor Vanessa McDonald
Scheme Early and Mid-Career Equipment Grant
Role Investigator
Funding Start 2017
Funding Finish 2017
GNo G1701222
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20163 grants / $600,943

Galectin-3 and phagocyte function in severe asthma$420,943

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Jodie Simpson, Doctor Katie Baines, Doctor Jay Horvat, Dr Johan Bylund
Scheme Project Grant
Role Investigator
Funding Start 2016
Funding Finish 2018
GNo G1500194
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Targeting neutrophil extracellular traps as a novel therapeutic option in COPD$160,000

Funding body: Lung Foundation Australia

Funding body Lung Foundation Australia
Project Team Doctor Katie Baines
Scheme Boehringer Ingelheim Chronic Obstructive Pulmonary Disease Research Fellowship
Role Lead
Funding Start 2016
Funding Finish 2020
GNo G1500407
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

A sputum gene expression signature of 6 biomarkers can predict azithromycin treatment responsiveness and future frequent exacerbations in severe asthma$20,000

Funding body: National Clinical CRE in Severe Asthma

Funding body National Clinical CRE in Severe Asthma
Project Team Doctor Katie Baines
Scheme Seed Research Project
Role Lead
Funding Start 2016
Funding Finish 2016
GNo G1600443
Type Of Funding Internal
Category INTE
UON Y

20153 grants / $155,222

Improving diet quality to reduce risk of asthma attacks in children$120,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Lisa Wood, Professor Joerg Mattes, Conjoint Professor Peter Wark, Doctor Katie Baines, Doctor Megan Jensen
Scheme Project Grant
Role Investigator
Funding Start 2015
Funding Finish 2016
GNo G1500957
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Targeting neutrophil extracellular traps as a novel therapeutic option in COPD$25,222

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Katie Baines, Conjoint Professor Peter Gibson
Scheme Research Grant
Role Lead
Funding Start 2015
Funding Finish 2015
GNo G1500570
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

(PROJECT)$10,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Vanessa McDonald, Mrs Netsanet Negewo, Conjoint Professor Peter Gibson, Doctor Katie Baines
Scheme Jennie Thomas Medical Research Travel Grant
Role Investigator
Funding Start 2015
Funding Finish 2015
GNo G1501430
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20146 grants / $269,397

Greenland Study$140,000

Funding body: Bispebjerg Hospital

Funding body Bispebjerg Hospital
Project Team Conjoint Professor Peter Gibson, Doctor Katie Baines, Professor Vibeke Backer
Scheme International Collaboration
Role Investigator
Funding Start 2014
Funding Finish 2016
GNo G1400539
Type Of Funding International - Non Competitive
Category 3IFB
UON Y

Identifying biomarkers that predict severe asthma exacerbations during pregnancy$60,000

Funding body: Thoracic Society of Australia and New Zealand

Funding body Thoracic Society of Australia and New Zealand
Project Team Doctor Katie Baines
Scheme TSANZ/National Asthma Council Australia - Asthma and Airways Career Development Fellowship
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400730
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Identifying biomarkers that predict severe asthma exacerbations during pregnancy$27,512

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Katie Baines, Emeritus Professor Michael Hensley
Scheme Research Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400631
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

The role of comorbidities and inflammation in Chronic Obstructive Pulmonary Disease (COPD)$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Mrs Netsanet Negewo, Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Doctor Katie Baines
Scheme Postgraduate Research Scholarship
Role Investigator
Funding Start 2014
Funding Finish 2015
GNo G1401393
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Predicting who is at risk of worsening lung disease in Cystic Fibrosis$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Peter Wark, Doctor Katie Baines, Professor Vanessa McDonald, Conjoint Professor Peter Gibson, Associate Professor Scott Bell, Associate Professor David Reid
Scheme Project Grant
Role Investigator
Funding Start 2014
Funding Finish 2014
GNo G1401410
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Thoracic Society of Australia and New Zealand, Adelaide Australia, 4-9 April 2014$1,885

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Katie Baines
Scheme Travel Grant
Role Lead
Funding Start 2014
Funding Finish 2014
GNo G1400186
Type Of Funding Internal
Category INTE
UON Y

20135 grants / $598,830

Gene Expression Biomarkers Predict Severe Asthma Inflammatory Phenotype, Activation Mechanisms and Treatment Response$465,629

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Katie Baines, Conjoint Professor Peter Gibson, Professor Jodie Simpson
Scheme Project Grant
Role Lead
Funding Start 2013
Funding Finish 2015
GNo G1200188
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Protracted bacterial bronchitis: long term outcomes, systemic and airway predictors of recurrence$86,526

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Anne Chang, Professor John Upham, Conjoint Professor Peter Gibson, Dr Stephanie Yerkovich, Doctor Katie Baines, Dr Sandra Hodge, Mrs Susan Pizzuto, Associate Professor Ian Masters, Dr Helen Buntain
Scheme Project Grant
Role Investigator
Funding Start 2013
Funding Finish 2016
GNo G1200534
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

BD FACSCanto II Violet Laser (405nm) upgrade including Trigon and 2 photomultiplier tubes (PMTs)$25,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Wark, Doctor Alan Hsu, Doctor Katie Baines, Professor Jodie Simpson, Conjoint Professor Peter Gibson, Ms Hayley See
Scheme Equipment Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1201180
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

DP73 Digital colour and monochrome camera + cellSens software + Xcite120 fluorescence lamp illuminator$20,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Laureate Professor Paul Foster, Doctor Alan Hsu, Professor Phil Hansbro, Professor Joerg Mattes, Doctor Katie Baines, Professor Jodie Simpson, Professor Rakesh Kumar, Doctor Nicole Hansbro, Doctor Steven Maltby, Doctor Ming Yang, Doctor Gerard Kaiko, Doctor Jay Horvat, Associate Professor Simon Keely, Doctor Andrew Jarnicki, Doctor Michael Fricker
Scheme Equipment Grant
Role Investigator
Funding Start 2013
Funding Finish 2013
GNo G1201186
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Thoracic Society of Australia and New Zealand$1,675

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Katie Baines
Scheme Travel Grant
Role Lead
Funding Start 2013
Funding Finish 2013
GNo G1300405
Type Of Funding Internal
Category INTE
UON Y

20125 grants / $435,832

2011 Research Fellowship - PRCARD$333,302

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Katie Baines
Scheme Research Fellowship
Role Lead
Funding Start 2012
Funding Finish 2014
GNo G1200356
Type Of Funding Internal
Category INTE
UON Y

Phenotype based management of severe persistent asthma$34,454

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Professor Vanessa McDonald, Doctor Katie Baines, Conjoint Professor Peter Gibson
Scheme Research Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200211
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Body plethysmograph respiratory function system$33,076

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Conjoint Professor Peter Wark, Professor Lisa Wood, Professor Jodie Simpson, Doctor Katie Baines, Doctor Vanessa Murphy, Doctor Jeffrey Pretto, Emeritus Professor Michael Hensley, Ms Jenny Mackney
Scheme Equipment Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100973
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Phenotype based management of severe persistent asthma$20,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Vanessa McDonald, Doctor Katie Baines, Conjoint Professor Peter Gibson
Scheme Research Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1101169
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Gene expression markers, mechanisms and steroid response of neutrophilic asthma$15,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Katie Baines
Scheme Fellowship Grant
Role Lead
Funding Start 2012
Funding Finish 2012
GNo G1200082
Type Of Funding Internal
Category INTE
UON Y

20117 grants / $92,989

Transcriptional Phenotyping of COPD and the relationship between neutrophilic airway inflammation, airway infection and activation of proinflammatory pathways$24,000

Funding body: John Hunter Hospital Charitable Trust

Funding body John Hunter Hospital Charitable Trust
Project Team Doctor Katie Baines, Conjoint Professor Peter Gibson, Professor Jodie Simpson
Scheme Research Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1100635
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Identification of a specific biomarker signature that identifies asthma phenotype $23,700

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Katie Baines, Professor Jodie Simpson, Conjoint Professor Peter Gibson
Scheme Project Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1001054
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Transcriptional Phenotyping of COPD and the relationship between neutrophilic airway inflammation, airway infection and activation of proinflammatory pathways$20,000

Funding body: Lung Foundation Australia

Funding body Lung Foundation Australia
Project Team Doctor Katie Baines
Scheme Grant-In-Aid for New and Emerging Researchers
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1000976
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Epigenetic changes in infants associated with maternal asthma during pregnancy$10,000

Funding body: Thoracic Society of Australia and New Zealand

Funding body Thoracic Society of Australia and New Zealand
Project Team Doctor Katie Baines
Scheme Grant-in-aid (supported by Merck Sharp & Dohme)
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1000991
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

Lung Function (Spirometry) testing and sputum induction equipment - establishing 3 new clinical workstations. Medgraphics CPFS/d USB spirometer with breezesuite software (x3). Laptop computer (x3). Ul$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Peter Gibson, Professor Jodie Simpson, Professor Lisa Wood, Doctor Katie Baines, Conjoint Professor Peter Wark, Doctor Vanessa Murphy
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100038
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

PULSE Education Prize$4,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Doctor Katie Baines
Scheme PULSE Education Prize
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1100342
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Thoracic Society of Australia and New Zealand, Perth Convention and Exhibition Centre, 2 - 6 April 2011$1,289

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Doctor Katie Baines
Scheme Travel Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1100297
Type Of Funding Internal
Category INTE
UON Y

20101 grants / $34,000

Real time PCR machine (Mastercycler ep realplex2 from Epprndorf) $34,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Jodie Simpson, Conjoint Professor Peter Gibson, Conjoint Professor Peter Wark, Professor Lisa Wood, Doctor Vanessa Murphy, Doctor Robert Scott, Doctor Katie Baines
Scheme Equipment Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000056
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20091 grants / $63,354

Epigenetic regulation of airways inflammation in non-eosinophilic asthma$63,354

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Conjoint Professor Peter Gibson, Doctor Katie Baines, Professor Jodie Simpson
Scheme PhD Scholarships
Role Investigator
Funding Start 2009
Funding Finish 2011
GNo G0189748
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON Y

20083 grants / $311,655

Molecular mechanisms and treatment of non-eosinophilic asthma$300,000

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Jodie Simpson, Doctor Katie Baines
Scheme Project Grant
Role Investigator
Funding Start 2008
Funding Finish 2010
GNo G0188825
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Molecular subtypes of asthma defined by gene expression profiling$9,955

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Katie Baines
Scheme Early Career Researcher Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0189618
Type Of Funding Internal
Category INTE
UON Y

American Thoracic Society, Metro Toronto Convention Centre, 16/5/2008 - 21/5/2008$1,700

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Katie Baines
Scheme Travel Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188599
Type Of Funding Internal
Category INTE
UON Y

20061 grants / $18,837

Molecular Pathogenesis of Non-Eosinophilic Asthma$18,837

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Doctor Katie Baines, Conjoint Professor Peter Gibson
Scheme PhD Scholarships
Role Lead
Funding Start 2006
Funding Finish 2006
GNo G0185985
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

20041 grants / $37,837

Molecular Pathogensis of Non-Eosinphilic Asthma$37,837

Funding body: Asthma Foundation of New South Wales

Funding body Asthma Foundation of New South Wales
Project Team Conjoint Professor Peter Gibson, Laureate Professor Rodney Scott, Doctor Katie Baines
Scheme PhD Scholarships
Role Investigator
Funding Start 2004
Funding Finish 2005
GNo G0183715
Type Of Funding Donation - Aust Non Government
Category 3AFD
UON Y

1 grants / $20,000

Gene expression profiling – a novel and efficient method for phenotyping severe asthma? $20,000

Funding body: National Clinical CRE in Severe Asthma

Funding body National Clinical CRE in Severe Asthma
Project Team Mr Marcus Christensen, Doctor Katie Baines
Scheme Seed Research Project
Role Lead
Funding Start
Funding Finish
GNo G1700752
Type Of Funding Internal
Category INTE
UON Y
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Research Supervision

Number of supervisions

Completed3
Current8

Total current UON EFTSL

PhD1.65

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2017 PhD Extracellular DNA (eDNA) in Pleural Fluid as a Determinant of Pathology and Treatment Response PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 PhD Investigating Aberrant Inflammatory Signaling in Asthma PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2016 PhD Dietary Fibre As A Modulator of Inflammation In Asthma PhD (Nutritional Biochemistry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2016 PhD Fruit and Vegetable Extract for the Reduction of Obesity-Induced Inflammation PhD (Nutritional Biochemistry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2015 PhD The effects of Galectin-3 on alveolar macrophage function in asthma PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2015 PhD Characterization of neutrophil subtypes in obstructive airway disease. PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2015 PhD Molecular and Cellular Characterisation of Severe Asthma PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2015 PhD Inflammatory gene expression profiling during pregnancy to predict future asthma exacerbations and poor maternal and neonatal outcomes PhD (Reproductive Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2017 PhD The Role of Comorbidities and Inflammation in COPD PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2017 PhD Fatty Acids and the Innate Immune Response PhD (Nutritional Biochemistry), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
2014 PhD Epigenetic Regulation of Airway Inflammation in Asthma PhD (Medicine), Faculty of Health and Medicine, The University of Newcastle Co-Supervisor
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News

NHMRC

NHMRC funding success 2016

November 13, 2015

Dr Katie Baines has been awarded more than $585,000 in NHMRC Project Grant funding commencing in 2016 for her research project Targeting neutrophil extracellular traps to reduce inflammation in severe asthma.

New study to examine fibre effect on asthma

June 15, 2015

Respiratory researchers from the University of Newcastle and HMRI are looking into whether a high-fibre diet can reduce airway inflammation in people with asthma.

Associate Professor Lisa Wood

Fruit-and-veg capsule set to combat obesity impacts

March 24, 2014

Hunter Medical Research Institute researchers are examining whether a simple fruit-and-vegetable supplement, taken in capsule form, can reduce inflammation produced by fat cells and thereby lower the risk of heart disease, diabetes, asthma and cancers in overweight people.

Dr Katie Baines

Position

Post-Doctoral Research Fellow
Respiratory Medicine
School of Medicine and Public Health
Faculty of Health and Medicine

Contact Details

Email katherine.baines@newcastle.edu.au
Phone (02) 40420090
Fax (02) 40420046

Office

Room Room 2109 Level 2 West Wing
Building Hunter Medical Research Institute
Location HMRI Building

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