ARC Discovery Project funding success
Laureate Professor John Aitken and Associate Professor Brett Nixon have been awarded more than $403,000 in ARC Discovery Project funding commencing in 2015 for their research project Use of quinone adducted peptides in the regulation of fertility.
About the project
This project describes a novel strategy for the non-surgical induction of sterility in male and female mammals with applications in the fields of biotechnology, veterinary medicine and the humane control of pest animal species. The approach is dependent upon the known sensitivity of the germ line to oxidative stress. The strategy rests upon the demonstration that quinone-adducted peptides will selectively bind to non-renewable cell types in the ovary and testis and redox cycle at the cell surface generating a highly localised state of oxidative stress. This stress will then recapitulate the impact of radiation on reproductive tissues by selectively compromising the viability of the germ line, inducing a state of sterility.