Research
With a multi-disciplinary and collaborative approach in mind, the Mark Hughes Foundation Centre for Brain Cancer Research encompasses discovery and clinical research in brain cancer, supported by a number of cross-cutting research themes and platforms ensuring a holistic approach and rapid translation to clinical practice.
Research Themes
Emerging therapeutics
Aiming to identify and test new and established drugs (drug repurposing) and develop sophisticated combination strategies to improve the outcomes of brain cancer patients.
Molecular mechanisms
Focusing on understanding the molecular basis of brain tumours through our research expertise in neuroscience, biochemistry, cancer biology, epigenetics, tumour microenvironment, and immuno-oncology.
Improved monitoring, surveillance and standard of care
Focusing on developing improved and/or novel diagnostic techniques (e.g. MRI, blood-based diagnostic tests) and treatment options (e.g. radiation, surgery) to improve outcomes for brain cancer patients.
Supportive Care
Utilising behavioural and implementation science approaches and our network of Brain Cancer Care Coordinators, we work with clinical and discovery science colleagues to understand and address the experiences of patients and families - including those in regional, rural and remote areas, in coping with the disease and its treatment.
Complementary therapies
Looking at the synergistic effect of complementary approaches (e.g. physical activity, nutrition, natural compounds) on conventional therapies and their potential use to overcome adverse effects in brain cancer patients.
Platforms
Clinical trials
Access to the largest throughput public centre for brain cancer surgery in NSW, providing a unique opportunity for clinical trials of new therapeutics and models of care, across diverse populations and geographic settings including patients from regional and rural centres.
Advanced Technologies
Using advanced and emerging technologies and extensive expertise we support the development and translation of discoveries in brain cancer research
- Genomics/Epigenomics
- Proteomics/Phosphoproteomics
- Nanomedicine/Drug delivery.
Biobanking
A sophisticated brain tissue biobanking platform, that ensures we have the resources necessary for discovery driven science and subsequent transition to translational research protocols.
The University of Newcastle acknowledges the traditional custodians of the lands within our footprint areas: Awabakal, Darkinjung, Biripai, Worimi, Wonnarua, and Eora Nations. We also pay respect to the wisdom of our Elders past and present.