The University of Newcastle, Australia

NHMRC funding success 2016

Tuesday, 10 November 2015

Professor Darryl Knight has been awarded more than $845,000 in NHMRC Project Grant funding commencing in 2016 for his research project Fibroblast Senescence as a driver of pulmonary fibrosis.


About the project

Idiopathic pulmonary fibrosis (IPF) has no cure. Currently we think that IPF develops like normal wound healing, but the normal "braking" mechanisms in the myofibroblasts (the cells that produce the connective tissue) don't work, such that too much connective tissue is produced and oxygen transfer to the blood is stopped. We have identified a protein we think stops, the myofibroblasts from dying. Reducing the activation of this protein should return the myofibroblasts function to normal.

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