Publications

Publications From The Last  5 Years

A list of publications from the Centre for Complex Disease and Precision Medicine staff and students with Prof. Murray Cairns as corresponding author.

Mahmoudi, Ebrahim, and Murray J. Cairns. 2023. ‘CircRNA and Ageing.’ Sub-Cellular Biochemistry 102: 249–70. https://doi.org/10.1007/978-3-031-21410-3_10.

Adams, Danielle M., William R. Reay, and Murray J. Cairns. 2023. ‘Multiomic Prioritisation of Risk Genes for Anorexia Nervosa.’ Psychological Medicine, February, 1–9. https://doi.org/10.1017/S0033291723000235.

Kiltschewskij, Dylan J., William R. Reay, and Murray J. Cairns. 2022. ‘Evidence of Genetic Overlap and Causal Relationships between Blood-Based Biochemical Traits and Human Cortical Anatomy.’ Translational Psychiatry 12 (1): 373. https://doi.org/10.1038/s41398-022-02141-3.

Reay, William R., Dylan J. Kiltschewskij, Michael P. Geaghan, Joshua R. Atkins, Vaughan J. Carr, Melissa J. Green, and Murray J. Cairns. 2022. ‘Genetic Estimates of Correlation and Causality between Blood-Based Biomarkers and Psychiatric Disorders.’ Science Advances 8 (14): eabj8969. https://doi.org/10.1126/sciadv.abj8969.

Reay, William R., Michael P. Geaghan, Joshua R. Atkins, Vaughan J. Carr, Melissa J. Green, and Murray J. Cairns. 2022. ‘Genetics-Informed Precision Treatment Formulation in Schizophrenia and Bipolar Disorder.’ American Journal of Human Genetics 109 (9): 1620–37. https://doi.org/10.1016/j.ajhg.2022.07.011.

Geaghan, Michael P., William R. Reay, and Murray J. Cairns. 2022. ‘MicroRNA Binding Site Variation Is Enriched in Psychiatric Disorders.’ Human Mutation 43 (12): 2153–69. https://doi.org/10.1002/humu.24481.

Greco, Laura A., William R. Reay, Christopher V. Dayas, and Murray J. Cairns. 2022. ‘Pairwise Genetic Meta-Analyses between Schizophrenia and Substance Dependence Phenotypes Reveals Novel Association Signals with Pharmacological Significance.’ Translational Psychiatry 12 (1): 403. https://doi.org/10.1038/s41398-022-02186-4.

Reay, William R., Michael P. Geaghan, and Murray J. Cairns. 2022. ‘The Genetic Architecture of Pneumonia Susceptibility Implicates Mucin Biology and a Relationship with Psychiatric Illness.’ Nature Communications 13 (1): 3756. https://doi.org/10.1038/s41467-022-31473-3.

Reay, William R., and Murray J. Cairns. 2021. ‘Advancing the Use of Genome-Wide Association Studies for Drug Repurposing.’ Nature Reviews. Genetics 22 (10): 658–71. https://doi.org/10.1038/s41576-021-00387-z.

Mahmoudi, Ebrahim, Melissa J. Green, and Murray J. Cairns. 2021. ‘Dysregulation of CircRNA Expression in the Peripheral Blood of Individuals with Schizophrenia and Bipolar Disorder.’ Journal of Molecular Medicine (Berlin, Germany) 99 (7): 981–91. https://doi.org/10.1007/s00109-021-02070-6.

Reay, William R., Sahar I. El Shair, Michael P. Geaghan, Carlos Riveros, Elizabeth G. Holliday, Mark A. McEvoy, Stephen Hancock, et al. 2021. ‘Genetic Association and Causal Inference Converge on Hyperglycaemia as a Modifiable Factor to Improve Lung Function.’ ELife 10 (March). https://doi.org/10.7554/eLife.63115.

Adams, Danielle M., William R. Reay, Michael P. Geaghan, and Murray J. Cairns. 2021. ‘Investigation of Glycaemic Traits in Psychiatric Disorders Using Mendelian Randomisation Revealed a Causal Relationship with Anorexia Nervosa.’ Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 46 (6): 1093–1102. https://doi.org/10.1038/s41386-020-00847-w.

Mahmoudi, Ebrahim, Joshua R. Atkins, Yann Quidé, William R. Reay, Heath M. Cairns, Chantel Fitzsimmons, Vaughan J. Carr, Melissa J. Green, and Murray J. Cairns. 2021. ‘The MIR137 VNTR Rs58335419 Is Associated With Cognitive Impairment in Schizophrenia and Altered Cortical Morphology.’ Schizophrenia Bulletin 47 (2): 495–504. https://doi.org/10.1093/schbul/sbaa123.

Kiltschewskij, Dylan J., Michael P. Geaghan, and Murray J. Cairns. 2020. ‘Characterising the Transcriptional and Translational Impact of the Schizophrenia-Associated MiR-1271-5p in Neuronal Cells.’ Cells 9 (4). https://doi.org/10.3390/cells9041014.

Khavari, Behnaz, and Murray J. Cairns. 2020. ‘Epigenomic Dysregulation in Schizophrenia: In Search of Disease Etiology and Biomarkers.’ Cells 9 (8). https://doi.org/10.3390/cells9081837.

Khavari, Behnaz, Ebrahim Mahmoudi, Michael P. Geaghan, and Murray J. Cairns. 2020. ‘Oxidative Stress Impact on the Transcriptome of Differentiating Neuroblastoma Cells: Implication for Psychiatric Disorders.’ International Journal of Molecular Sciences 21 (23). https://doi.org/10.3390/ijms21239182.

Reay, William R., and Murray J. Cairns. 2020a. ‘Pairwise Common Variant Meta-Analyses of Schizophrenia with Other Psychiatric Disorders Reveals Shared and Distinct Gene and Gene-Set Associations.’ Translational Psychiatry 10 (1): 134. https://doi.org/10.1038/s41398-020-0817-7.

Reay, William R., Joshua R. Atkins, Vaughan J. Carr, Melissa J. Green, and Murray J. Cairns. 2020. ‘Pharmacological Enrichment of Polygenic Risk for Precision Medicine in Complex Disorders.’ Scientific Reports 10 (1): 879. https://doi.org/10.1038/s41598-020-57795-0.

Reay, William R., Joshua R. Atkins, Yann Quidé, Vaughan J. Carr, Melissa J. Green, and Murray J. Cairns. 2020. ‘Polygenic Disruption of Retinoid Signalling in Schizophrenia and a Severe Cognitive Deficit Subtype.’ Molecular Psychiatry 25 (4): 719–31. https://doi.org/10.1038/s41380-018-0305-0.

Reay, William R., and Murray J. Cairns. 2020b. ‘The Role of the Retinoids in Schizophrenia: Genomic and Clinical Perspectives.’ Molecular Psychiatry 25 (4): 706–18. https://doi.org/10.1038/s41380-019-0566-2.

Kiltschewskij, Dylan J., and Murray J. Cairns. 2020. ‘Transcriptome-Wide Analysis of Interplay between MRNA Stability, Translation and Small RNAs in Response to Neuronal Membrane Depolarization.’ International Journal of Molecular Sciences 21 (19). https://doi.org/10.3390/ijms21197086.

Liu, Xiaoman, Siew-Kee Low, Joshua R. Atkins, Jing Qin Wu, William R. Reay, Heath M. Cairns, Melissa J. Green, et al. 2020. ‘Wnt Receptor Gene FZD1 Was Associated with Schizophrenia in Genome-Wide SNP Analysis of the Australian Schizophrenia Research Bank Cohort.’ The Australian and New Zealand Journal of Psychiatry 54 (9): 902–8. https://doi.org/10.1177/0004867419885443.

Geaghan, Michael P., Joshua R. Atkins, Alan M. Brichta, Paul A. Tooney, Rodney J. Scott, Vaughan J. Carr, and Murray J. Cairns. 2019. ‘Alteration of MiRNA-MRNA Interactions in Lymphocytes of Individuals with Schizophrenia.’ Journal of Psychiatric Research 112 (May): 89–98. https://doi.org/10.1016/j.jpsychires.2019.02.023.

Mahmoudi, Ebrahim, Chantel Fitzsimmons, Michael P. Geaghan, Cynthia Shannon Weickert, Joshua R. Atkins, Xi Wang, and Murray J. Cairns. 2019. ‘Circular RNA Biogenesis Is Decreased in Postmortem Cortical Gray Matter in Schizophrenia and May Alter the Bioavailability of Associated MiRNA.’ Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology 44 (6): 1043–54. https://doi.org/10.1038/s41386-019-0348-1.

Mahmoudi, E., and M. J. Cairns. 2019. ‘Circular RNAs Are Temporospatially Regulated throughout Development and Ageing in the Rat.’ Scientific Reports 9 (1): 2564. https://doi.org/10.1038/s41598-019-38860-9.

Mahmoudi, Ebrahim, Dylan Kiltschewskij, Chantel Fitzsimmons, and Murray J. Cairns. 2019. ‘Depolarization-Associated CircRNA Regulate Neural Gene Expression and in Some Cases May Function as Templates for Translation.’ Cells 9 (1). https://doi.org/10.3390/cells9010025.

Santarelli, Danielle M., Adam P. Carroll, Heath M. Cairns, Paul A. Tooney, and Murray J. Cairns. 2019. ‘Schizophrenia-Associated MicroRNA-Gene Interactions in the Dorsolateral Prefrontal Cortex.’ Genomics, Proteomics & Bioinformatics 17 (6): 623–34. https://doi.org/10.1016/j.gpb.2019.10.003.

Cairns, Murray J. 2019. ‘Small RNA Regulators of Social Behaviour in Eutherian Mammals.’ EMBO Reports 20 (2). https://doi.org/10.15252/embr.201947663.

Kiltschewskij, Dylan, and Murray J. Cairns. 2019. ‘Temporospatial Guidance of Activity-Dependent Gene Expression by MicroRNA: Mechanisms and Functional Implications for Neural Plasticity.’ Nucleic Acids Research 47 (2): 533–45. https://doi.org/10.1093/nar/gky1235.

Highly Cited Articles Published By Our Collaborators

These highly cited publications are the result of collaborations between Centre for Complex Disease and Precision Medicine personnel and other researchers.

Anttila, V., et al., (2018). Analysis of shared heritability in common disorders of the brain. Science (New York, N.Y.), 360(6395). https://doi.org/10.1126/science.aap8757

Bipolar Disorder and Schizophrenia Working Group of the Psychiatric Genomics Consortium.  (2018). Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes. Cell, 173(7), 1705-1715.e16. https://doi.org/10.1016/j.cell.2018.05.046

Cross-Disorder Group of the Psychiatric Genomics Consortium. (2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell, 179(7), 1469-1482.e11. https://doi.org/10.1016/j.cell.2019.11.020

Grasby, K. L. et al., (2020). The genetic architecture of the human cerebral cortex. Science (New York, N.Y.), 367(6484). https://doi.org/10.1126/science.aay6690

Kamitaki, N. et al., (2020). Complement genes contribute sex-biased vulnerability in diverse disorders. Nature, 582(7813), 577–581. https://doi.org/10.1038/s41586-020-2277-x

Mullins, N. et al., (2021). Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology. Nature Genetics, 53(6), 817–829. https://doi.org/10.1038/s41588-021-00857-4

Mullins, N. et al., (2022). Dissecting the Shared Genetic Architecture of Suicide Attempt, Psychiatric Disorders, and Known Risk Factors. Biological Psychiatry, 91(3), 313–327. https://doi.org/10.1016/j.biopsych.2021.05.029

Radua, J. et al., (2020). Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA. NeuroImage, 218, 116956. https://doi.org/10.1016/j.neuroimage.2020.116956

Trubetskoy, V. et al., (2022). Mapping genomic loci implicates genes and synaptic biology in schizophrenia. Nature, 604(7906), 502–508. https://doi.org/10.1038/s41586-022-04434-5

van Erp, T. G. M. et al., (2018). Cortical Brain Abnormalities in 4474 Individuals With Schizophrenia and 5098 Control Subjects via the Enhancing Neuro Imaging Genetics Through Meta Analysis  (ENIGMA) Consortium. Biological Psychiatry, 84(9), 644–654. https://doi.org/10.1016/j.biopsych.2018.04.023

Wang, X., Cairns, M. J., & Yan, J. (2019). Super-enhancers in transcriptional regulation and genome organization. Nucleic Acids Research, 47(22), 11481–11496. https://doi.org/10.1093/nar/gkz1038