| 2021 |
Powis DA, Munro D, Bore MR, 'Is the UCAT appropriate for selecting undergraduate medical students?', MEDICAL JOURNAL OF AUSTRALIA, 214 77-78 (2021)
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| 2020 |
Powis D, Munro D, Bore M, Eley D, 'Why is it so hard to consider personal qualities when selecting medical students?', Medical Teacher, 42 366-371 (2020) [C1]
Having ¿good¿ doctors is important to everybody. How to select medical students better has been discussed repeatedly for more than seventy years, implying that prevailing methods ... [more] Having ¿good¿ doctors is important to everybody. How to select medical students better has been discussed repeatedly for more than seventy years, implying that prevailing methods could be improved. A significant body of research exists about selection methods and their application in medicine. Yet most medical schools world-wide continue to use prior academic performance and cognitive ability as their major criteria for selection, with minor or no consideration of personal qualities and interpersonal skills (possibly assuming they will develop naturally during training and practice). We describe the main methods available for assessing personal qualities of applicants to medical school and have attempted to identify some reasons and systemic disincentives working against their adoption.
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| 2020 |
Powis D, Munro D, Bore M, Burstal A, 'In-course and career outcomes predicted by medical school selection procedures based on personal qualities', Medical Teacher, 42 944-946 (2020) [C1]
This paper reports a 40-year follow-up of 57 graduates from the initial intake to an Australian medical school who were selected on the basis of either academic criteria alone or ... [more] This paper reports a 40-year follow-up of 57 graduates from the initial intake to an Australian medical school who were selected on the basis of either academic criteria alone or desirable personal qualities as assessed by non-cognitive tests and an interview (with a third small group satisfying both criteria). Both students and teaching staff have remained blind to the basis for selection until the present day. Analysis of their under- and post-graduate careers indicates that ¿academic¿ entrants were more likely to complete an intercalated BMedSci degree and to become specialists, while ¿personal qualities¿ entrants were more likely to graduate with honours, become GPs, and win higher degrees after graduation. However, gender more significantly predicted these outcomes, with female results similar to ¿personal qualities¿ entrants and males¿ similar to ¿academic.¿ The results are interpreted with reference to the aims and structure of the Newcastle medicine curriculum.
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| 2019 |
Fukui Y, Noda S, Okada M, Mihara N, Bore M, Munro D, Powis D, 'Reliability of personality and values tests: The effects of "high stakes" selection conditions, and of four years in medical school.', Medical teacher, 41 591-597 (2019) [C1]
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| 2018 |
Lynagh M, Horton G, Nair BK, Walker M, Kelly B, Powis D, 'Student selection for medicine: Still a Thorny issue', Archives of Medicine and Health Sciences, 6 (2018) [C1]
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| 2017 |
Adam J, Bore M, Childs R, Dunn J, McKendree J, Munro D, Powis D, 'Response to: 'How effective are selection methods in medical education? A systematic review'', MEDICAL EDUCATION, 51 669-669 (2017)
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| 2015 |
Powis D, 'Selecting medical students: An unresolved challenge', Medical Teacher, 37 252-260 (2015) [C1]
Despite the abundant supply of academically outstanding applicants to medical schools in most countries the regularly recurring debate in the academic literature, and indeed somet... [more] Despite the abundant supply of academically outstanding applicants to medical schools in most countries the regularly recurring debate in the academic literature, and indeed sometimes in the popular media, implies that admissions committees are still getting it wrong in a significant number of instances. How can this be so when our procedures are directed unashamedly at selecting the most highly academically and intellectually qualified students in the expectation that they will make the best doctors? Perhaps it is time for a radical change in emphasis. Instead of endeavouring to differentiate among the top ranks of a pool of outstandingly qualified applicants, the selection effort might be better focused on identifying those potentially unsuitable in terms of their non-academic personal qualities to ensure they do not gain entry. The account that follows is an analysis of the problems of medical student selection and offers a potential solution - a solution that was first suggested in the medical literature 70 years ago, but not adopted. It is the present author's contention that the cycle of debate will continue to recur unless such an approach is pursued.
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| 2015 |
Pitt V, Powis D, Levett-Jones T, Hunter S, 'The influence of critical thinking skills on performance and progression in a pre-registration nursing program', Nurse Education Today, 35 125-131 (2015) [C1]
Background: The importance of developing critical thinking skills in preregistration nursing students is recognized worldwide. Yet, there has been limited exploration of how stude... [more] Background: The importance of developing critical thinking skills in preregistration nursing students is recognized worldwide. Yet, there has been limited exploration of how students' critical thinking skill scores on entry to pre-registration nursing education influence their academic and clinical performance and progression. Aim: The aim of this study was to: i) describe entry and exit critical thinking scores of nursing students enrolled in a three year bachelor of nursing program in Australia in comparison to norm scores; ii) explore entry critical thinking scores in relation to demographic characteristics, students' performance and progression. Method: This longitudinal correlational study used the Health Sciences Reasoning Test (HSRT) to measure critical thinking skills in a sample (. n=. 134) of students, at entry and exit (three years later). A one sample t-test was used to determine if differences existed between matched student critical thinking scores between entry and exit points. Academic performance, clinical performance and progression data were collected and correlations with entry critical thinking scores were examined. Results: There was a significant relationship between critical thinking scores, academic performance and students' risk of failing, especially in the first semester of study. Critical thinking scores were predictive of program completion within three years. The increase in critical thinking scores from entry to exit was significant for the 28 students measured. In comparison to norm scores, entry level critical thinking scores were significantly lower, but exit scores were comparable. Critical thinking scores had no significant relationship to clinical performance. Conclusion: Entry critical thinking scores significantly correlate to academic performance and predict students risk of course failure and ability to complete a nursing degree in three years. Students' critical thinking scores are an important determinant of their success and as such can inform curriculum development and selection strategies.
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| 2015 |
Adam J, Bore M, Childs R, Dunn J, Mckendree J, Munro D, Powis D, 'Predictors of professional behaviour and academic outcomes in a UK medical school: A longitudinal cohort study', Medical Teacher, 37 868-880 (2015) [C1]
Background: Over the past 70 years, there has been a recurring debate in the literature and in the popular press about how best to select medical students. This implies that we ar... [more] Background: Over the past 70 years, there has been a recurring debate in the literature and in the popular press about how best to select medical students. This implies that we are still not getting it right: either some students are unsuited to medicine or the graduating doctors are considered unsatisfactory, or both.Aim: To determine whether particular variables at the point of selection might distinguish those more likely to become satisfactory professional doctors, by following a complete intake cohort of students throughout medical school and analysing all the data used for the students selection, their performance on a range of other potential selection tests, academic and clinical assessments throughout their studies, and records of professional behaviour covering the entire five years of the course.Methods: A longitudinal database captured the following anonymised information for every student (n = 146) admitted in 2007 to the Hull York Medical School (HYMS) in the UK: demographic data (age, sex, citizenship); performance in each component of the selection procedure; performance in some other possible selection instruments (cognitive and non-cognitive psychometric tests); professional behaviour in tutorials and in other clinical settings; academic performance, clinical and communication skills at summative assessments throughout; professional behaviour lapses monitored routinely as part of the fitness-to-practise procedures. Correlations were sought between predictor variables and criterion variables chosen to demonstrate the full range of course outcomes from failure to complete the course to graduation with honours, and to reveal clinical and professional strengths and weaknesses.Results: Student demography was found to be an important predictor of outcomes, with females, younger students and British citizens performing better overall. The selection variable "HYMS academic score", based on prior academic performance, was a significant predictor of components of Year 4 written and Year 5 clinical examinations. Some cognitive subtest scores from the UK Clinical Aptitude Test (UKCAT) and the UKCAT total score were also significant predictors of the same components, and a unique predictor of the Year 5 written examination. A number of the non-cognitive tests were significant independent predictors of Years 4 and 5 clinical performance, and of lapses in professional behaviour. First- and second-year tutor ratings were significant predictors of all outcomes, both desirable and undesirable. Performance in Years 1 and 2 written exams did not predict performance in Year 4 but did generally predict Year 5 written and clinical performance.Conclusions: Measures of a range of relevant selection attributes and personal qualities can predict intermediate and end of course achievements in academic, clinical and professional behaviour domains. In this study HYMS academic score, some UKCAT subtest scores and the total UKCAT score, and some non-cognitive tests completed at the outset of studies, together predicted outcomes most comprehensively. Tutor evaluation of students early in the course also identified the more and less successful students in the three domains of academic, clinical and professional performance. These results may be helpful in informing the future development of selection tools.
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| 2014 |
Skelding KA, Arellano JM, Powis DA, Rostas JA, 'Excitotoxic stimulation of brain microslices as an in vitro model of stroke.', J Vis Exp, e51291 (2014) [C1]
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| 2014 |
Pitt V, Powis D, Levett-Jones T, Hunter S, 'Nursing students' personal qualities: a descriptive study.', Nurse Educ Today, 34 1196-1200 (2014) [C1]
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| 2014 |
Pitt V, Powis D, Levett-Jones T, Hunter S, 'The influence of personal qualities on performance and progression in a pre-registration nursing programme', Nurse Education Today, 34 866-871 (2014) [C1]
Background: Research conducted primarily with psychology and medical students has highlighted that personal qualities play an important role in students' academic performance... [more] Background: Research conducted primarily with psychology and medical students has highlighted that personal qualities play an important role in students' academic performance. In nursing there has been limited investigation of the relationship between personal qualities and performance. Yet, reports of student incivility and a lack of compassion have prompted appeals to integrate the assessment of personal qualities into pre-registration nursing student selection. Before this can be done research is needed to explore the influence of students' personal qualities on programme performance and progression. Aim: This study explores the relationships between students' personal qualities and their academic and clinical performance, behaviours and progression through a pre-registration nursing programme in Australia. Method: This longitudinal descriptive correlational study was undertaken with a sample of Australian pre-registration nursing students (n=138). Students' personal qualities were assessed using three personal qualities assessment (PQA) instruments. Outcome measures included grades in nursing theory and clinical courses, yearly grade point average, final clinical competency, progression (completion), class attendance and levels of life event stress. Results: Significant correlations were found between academic performance and PQA scores for self-control, resilience and traits of aloofness, confidence and involvement. Final clinical competence was predicted by confidence and self-control scores. Students with higher empathy had higher levels of life event stress in their first year and class attendance had a positive correlation with self-control. Completing the programme in three years was weakly predicted by the measure of resilience. No difference was noted between extreme or non-extreme scorers on the PQA scales with respect to performance or progression. Conclusion: This sample of students' personal qualities was found to influence their academic and clinical performance and their ability to complete a pre-registration programme in three years. However, further research is required with larger cohorts to confirm the use of personal qualities assessment during selection. © 2013 Elsevier Ltd.
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| 2014 |
Fukui Y, Noda S, Okada M, Mihara N, Kawakami Y, Bore M, et al., 'Trial Use of the Personal Qualities Assessment (PQA) in the Entrance Examination of a Japanese Medical University: Similarities to the Results in Western Countries', Teaching and Learning in Medicine, 26 357-363 (2014) [C1]
Background: The Personal Qualities Assessment (PQA), developed by the University of Newcastle, Australia to assess the aptitude of future medical professionals, has been used in W... [more] Background: The Personal Qualities Assessment (PQA), developed by the University of Newcastle, Australia to assess the aptitude of future medical professionals, has been used in Western countries. Purposes: The objective was to investigate whether the PQA is appropriate for Japanese medical school applicants. Methods: Two of the PQA tests, Libertarian-Dual-Communitarian moral orientations (Mojac) and Narcissism, Aloofness, Confidence, and Empathy (NACE), were translated into Japanese, and administered at the Tokyo Women's Medical University entrance examinations from 2007 to 2009. Results: The distributions of the applicants¿ Mojac and NACE scores were close to the normal distribution, and the mean scores did not exhibit a large difference from those in Western countries. The only significant difference was that the mean score of the NACE test was slightly lower than the Western norm. Conclusions: The translated PQA tests may be appropriate for use with Japanese applicants, though further research considering cultural differences is required.
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| 2013 |
Hurwitz S, Kelly B, Powis D, Smyth R, Lewin T, 'The desirable qualities of future doctors - A study of medical student perceptions', MEDICAL TEACHER, 35 E1332-E1339 (2013) [C1]
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| 2013 |
Nedjat S, Bore M, Majdzadeh R, Rashidian A, Munro D, Powis D, et al., 'Comparing the cognitive, personality and moral characteristics of high school and graduate medical entrants to the Tehran University of Medical Sciences in Iran', Medical Teacher, 35 e1632-e1637 (2013) [C1]
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| 2013 |
Tsou K-I, Lin C-S, Cho S-L, Powis D, Bore M, Munro D, et al., 'Using Personal Qualities Assessment to Measure the Moral Orientation and Personal Qualities of Medical Students in a Non-Western Culture', EVALUATION & THE HEALTH PROFESSIONS, 36 174-190 (2013) [C1]
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| 2013 |
Pitt V, Powis D, Levett-Jones T, Hunter S, 'Can an existing personal qualities measure be used to examine nursing students' professional and personal attributes?', Focus on Health Professional Education: A Multi-disciplinary Journal, 15 41-54 (2013) [C1]
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| 2012 |
Pitt VL, Powis DA, Levett-Jones TL, Hunter S, 'Factors influencing nursing students' academic and clinical performance and attrition: An integrative literature review', Nurse Education Today, 32 903-913 (2012) [C1]
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| 2012 |
Adam J, Bore MR, McKendree J, Munro D, Powis DA, 'Can personal qualities of medical students predict in-course examination success and professional behaviour? An exploratory prospective cohort study', BMC Medical Education, 12 (2012) [C1]
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| 2011 |
McManus IC, Ferguson E, Wakeford R, Powis DA, James D, 'Response to comments by Emery and Bell, Medical Teacher 33(1): (this issue)', Medical Teacher, 33 60-61 (2011) [C3]
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| 2011 |
McManus IC, Ferguson E, Wakeford R, Powis DA, James D, 'Predictive validity of the Biomedical Admissions Test: An evaluation and case study', Medical Teacher, 33 53-57 (2011) [C1]
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| 2011 |
Prideaux D, Roberts C, Eva K, Centeno A, McCrorie P, McManus C, et al., 'Assessment for selection for the health care professions and specialty training: Consensus statement and recommendations from the Ottawa 2010 Conference', Medical Teacher, 33 215-223 (2011) [C1]
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| 2011 |
Dowell J, Lumsden MA, Powis DA, Munro D, Bore MR, Makubate B, Kumwenda B, 'Predictive validity of the personal qualities assessment for selection of medical students in Scotland', Medical Teacher, 33 E485-E488 (2011) [C1]
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| 2010 |
Powis DA, 'Improving the selection of medical students', British Medical Journal, 340 3 (2010) [C3]
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| 2009 |
James D, Ferguson E, Powis DA, Bore MR, Munro D, Symonds IM, Yates J, 'Graduate entry to medicine: Widening psychological diversity', BMC Medical Education, 9 1-8 (2009) [C1]
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| 2009 |
Bore MR, Munro D, Powis DA, 'A comprehensive model for the selection of medical students', Medical Teacher, 31 1066-1072 (2009) [C1]
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| 2009 |
Powis DA, 'Personality testing in the context of selecting health professionals', Medical Teacher, 31 1045-1046 (2009) [C3]
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| 2008 |
Powis DA, 'Selecting medical students - Reply', MEDICAL JOURNAL OF AUSTRALIA, 189 236-236 (2008) [C3] |
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| 2008 |
Powis DA, 'In reply', Medical Journal of Australia, 189 236 (2008) [C3] |
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| 2008 |
Powis DA, 'Selecting medical students', Medical Journal of Australia, 188 323-324 (2008) [C3]
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| 2008 |
Powis DA, 'In Reply [Letter]', Medical Journal of Australia, 189 236 (2008) [C3] |
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| 2008 |
James D, Feguson E, Powis DA, Symonds I, Yates J, 'Graduate entry to medicine: Widening academic and socio-demographic access', Medical Education, 42 294-300 (2008) [C1]
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| 2007 |
Powis DA, James D, Ferguson E, 'Demographic and socio-economic associations with academic attainment (UCAS tariff scores) in applicants to medical school', Medical Education, 41 242-249 (2007) [C1]
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| 2007 |
Gibbons JL, Bore MR, Munro D, Powis DA, 'Using personal quality assessment for selection of social work students', Australian Social Work, 60 210-221 (2007) [C1]
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| 2007 |
Migues PV, Cammarota MP, Kavanagh J, Atkinson RJ, Powis DA, Rostas JA, 'Maturational changes in the subunit composition of AMPA receptors and the functional consequences of their activation in chicken forebrain', Developmental Neuroscience, 29 232-240 (2007) [C1]
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| 2007 |
Powis DA, Hamilton J, McManus IC, 'Widening access by changing the criteria for selecting medical students', Teaching and Teacher Education, 23 1235-1245 (2007) [C1]
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| 2007 |
McManus C, Powis DA, 'Testing medical school selection tests (Editorial)', Medical Journal of Australia, 186 118-119 (2007) [C3]
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| 2006 |
Lyons MJ, Mackenzie LA, Bore MR, Powis DA, 'Framing a set of non-academic selection criteria for occupational therapy students: An Australian study', Australian Occupational Therapy Journal, 53 284-292 (2006) [C1]
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| 2006 |
Powis DA, Bore MR, Munro D, 'Selecting medical students - Evidence based admissions procedures for medical students are being tested (letter)', British Medical Journal, 332 1156-1156 (2006) [C3]
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| 2006 |
Wright B, Scott I, Powis DA, Woloschuk W, Henry R, Turnbull D, Ryan G, 'Career preferences of new medical students at four Australian universities: Rural family medicine versus the rest', Australian Journal of Rural Health, 14 229-230 (2006) [C1]
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| 2005 |
Bore MR, Lyall DG, Dempsey SE, Powis DA, 'Assessment of Personal Qualities in Selection of Medical Radiation Science Students', Journal of Nuclear Medicine Technology, 33 180-185 (2005) [C1]
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| 2005 |
Bore MR, Munro D, Kerridge I, Powis DA, 'Not moral reasoning: A Libertarian - Communitarian dimension of moral orientation adn Schwartz's value types', Australian Journal of Psychology, 57 38-48 (2005) [C1]
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| 2005 |
Munro D, Bore MR, Powis DA, 'Personality factors in professional ethical behaviour: Studies of empathy and narcissism', Australian Journal of Psychology, 57 49-60 (2005) [C1]
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| 2005 |
Lumsden MA, Bore MR, Millar K, Jack R, Powis DA, 'Assessment of personal qualities in relation to admission to medical school', Medical Education, 39 258-265 (2005) [C1]
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| 2005 |
Bore MR, Munro D, Kerridge I, Powis DA, 'Selection of medical students according to their moral orientation', Medical Education, 39 266-275 (2005) [C1]
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| 2005 |
McManus IC, Powis DA, Wakeford R, Ferguson E, James D, Richards P, 'Intellectual aptitude tests and A levels for selecting UK school leaver entrants for medical school', British Medical Journal, 331 555-559 (2005) [C1]
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| 2005 |
Powis DA, Bore MR, Munro D, Lumsden MA, 'Development of the Personal Qualities Assessment as a Tool for Selecting Medical Students', Journal of Adult & Continuing Education, 11 03-14 (2005) [C1]
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| 2004 |
Bore MR, Munro D, Powis DA, 'The Schwartz value model and a three-factor model of morality', Australian Journal of Psychology, 56 58 (2004) [C3]
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| 2004 |
Powis DA, Hamilton J, Gordon J, 'Are graduate entry programmes the answer to recruiting and selecting tomorrow's doctors?', Medical Education, 38 1147-1153 (2004) [C1]
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| 2003 |
Bore MR, Munro D, Kerridge I, Powis DA, 'Libertarian and communitarian moral orientations and Schwartz's individual and collective value types', Australian Journal of Psychology, 55 35 (2003) [C3]
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| 2003 |
Munro D, Bore MR, 'Personality factors in interpersonal behaviour: Explorations with Horney's type theory', Australian Journal of Psychology, 55 54 (2003) [C3]
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| 2003 |
Munro D, Bore MR, Powis DA, 'Personality factors in professional ethical behaviour: Studies of empathy and narcissism', Australian Journal of Psychology, 55 54 (2003) [C3]
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| 2003 |
Powis DA, 'Selecting Medical Students', Medical Education, 37 1064-1065 (2003) [C3]
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| 2003 |
Powis DA, Zerbes M, Herd LM, Dunkley PR, 'Angiotensin II Causes Calcium Entry into Bovine Adrenal Chromaffin Cells via Pathway(s) Activated by Depletion of Intracellular Calcium Stores', Neurochemical Research, 28 1299-1306 (2003) [C1]
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| 2002 |
Powis DA, Marley P, 'Ions, Channels, and Receptors', Annals of the New York Academy of Sciences, 971 95-99 (2002) [C1]
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| 2002 |
Powis DA, Zerbes M, 'In situ Chelation of Ca2+ In Intracellular Stores Induces Capacitative Ca2+ Entry in Bovine Adrenal Chromaffin Cells', Annals of the New York Academy of Sciences, 971 150-152 (2002) [C1]
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| 2001 |
Zerbes M, Clark CL, Powis DA, 'Neurotransmitter release from bovine adrenal chromaffin cells is modulated by capacitative Ca2+ entry driven by depleted internal Ca2+ stores', Cell Calcium, 29(1) 49-58 (2001) [C1]
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| 2001 |
Lowe M, Kerridge I, Bore M, Munro D, Powis DA, 'Is is possible to assess the "ethics" of medical school applicants?', Journal of Medical Ethics, 27 404-408 (2001) [C1]
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| 2001 |
Lowe M, Kerridge I, Bore MR, Munro D, Powis D, 'Is it possible to assess the "ethics" of medical school applicants?', Journal of Medical Ethics, 27 404-408 (2001) [C1]
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| 2001 |
Grey M, Pearson S, Rolfe IE, Kay F, Powis D, 'How do Australian Doctors with Different Pre-medical School Backgrounds Perform as Interns', Education for Health, 14 87-96 (2001) [C1]
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| 2000 |
Roberts-Thomson EL, Saunders H, Palmer SM, Powis DA, Dunkley PR, Bunn SJ, 'Ca2+ influx stimulated phospholipase C activity in bovine adrenal chromaffin cells: responses to K+ depolarization and histamine', European Journal of Pharmacology, 398 199-207 (2000) [C1]
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| 2000 |
Roberts-Thomson EL, Saunders H, Palmer S, Powis DA, Dunkley P, Bunn S, 'Ca2+ influx stimulated phosopholipase C activity in bovine adrenal chromaffin cells: responses to K+ depolarization and histamine', European Journal of Pharmacology, 398 199-207 (2000) [C1] |
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| 2000 |
Marley P, Bales P, Zerbes M, Powis DA, O'Farrell M, 'Mobilizing Store Ca2+ in the Presence of La3+ Evokes Exocytosis in Bovine Chromaffin Cells', Journal of Neurochemistry, 75(3) 1162-1171 (2000) [C1]
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| 2000 |
Roberts-Thomson EL, Palmer S, Powis DA, Bunn S, 'Histamine-stimulated phospholipase C activity in bovine adrenal medullary chromaffin cells: the effect of chloride-channel antagonists and low extracellular chloride concentrations', Neuroscience Letters, 278 93-96 (2000) [C1]
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| 1999 |
Bales P, Zerbes M, Powis DA, Marley P, 'Effect of Gd3+ on bradykinin-induced catecholamine secretion from bovine adrenal chromaffin cells', British Journal of Pharmacology, 128 1435-1444 (1999) [C1]
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| 1999 |
Powis DA, Marley P, Schneider A, 'Ins and Outs of Calcium : a workshop on chromaffin cells', Cell Calcium, 26(3/4) 91-94 (1999) [C1]
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| 1998 |
Powis D, 'Select medical students.', BMJ, 317 1149-1150 (1998)
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| 1998 |
Powis DA, 'How to do it
Select medical students', British Medical Journal, 317 1149-1150 (1998) [C1]
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| 1998 |
Zerbes M, Bunn S, Powis DA, 'Histamine causes Ca2+ entry via both a store-operated and a store-independent pathway in bovine adrenal chromaffin cells', Cell Calcium, 23(6) 379-386 (1998) [C1]
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| 1998 |
Powis DA, Rolfe I, 'Selection and Performance of Medical Students at Newcastle, New South Wales', Education for Health, 11 (1) 15-23 (1998) [C1]
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| 1998 |
Powis D, Rolfe I, 'An evidence-based admissions process at Newcastle (New South Wales) Medical School [1]', Education for Health, 11 409-410 (1998)
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| 1997 |
Rolfe IE, Powis DA, 'Selecting Australian doctors of the future', MEDICAL JOURNAL OF AUSTRALIA, 166 229-230 (1997)
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| 1997 |
Powis DA, Bristow T, 'Top school marks don't necessarily make top medical students', MEDICAL JOURNAL OF AUSTRALIA, 166 613-613 (1997)
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| 1997 |
Rolfe IE, Powis DA, 'Selecting Australian doctors of the future. Will the new selection criteria for entry to medical school affect delivery of health care in Australia?', Medical Journal of Australia, 166 229-230 (1997)
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| 1996 |
Dunkley PR, Cote A, Harrison SM, Herd L, Hall A, Powis DA, 'Tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells - Clonidine stimulates basal but inhibits nicotinic receptor evoked phosphorylation', BIOCHEMICAL PHARMACOLOGY, 51 239-245 (1996)
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| 1996 |
Powis DA, OBrien KJ, Harrison SM, Jarvie PE, Dunkley PR, 'Mn2+ can substitute for Ca2+ in causing catecholamine secretion but not for increasing tyrosine hydroxylase phosphorylation in bovine adrenal chromaffin cells', CELL CALCIUM, 19 419-429 (1996)
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| 1996 |
Powis DA, O'Brien KJ, Harrison SM, Jarvie PE, Dunkley PR, 'Mn
The ability of the divalent cation manganese (Mn2+) to substitute for calcium (Ca2+) both in triggering catecholamine release and in stimulating catecholamine synthesis, as indica... [more] The ability of the divalent cation manganese (Mn2+) to substitute for calcium (Ca2+) both in triggering catecholamine release and in stimulating catecholamine synthesis, as indicated by an increase in tyrosine hydroxylase (TOH) phosphorylation, has been determined in bovine adrenal medullary chromaffin cells maintained in tissue culture. Mn2+ was found to enter chromaffin cells through pathways activated by nicotinic receptor stimulation and potassium depolarisation, and via the Nai:Cao exchange mechanism in Na+-loaded cells. Like Ca2+, entry of Mn2+ through these pathways triggered immediate catecholamine release and, like Ca2+, maintained quantitatively comparable release at least up to 40 min. Unlike Ca2+, Mn2+ did not stimulate an increase in TOH phosphorylation in intact chromaffin cells, even over a prolonged time course, but Mn2+ did stimulate increased TOH phosphorylation in lysed cell preparations showing that its lack of effect in the intact cells was not due to inhibition of the specific phosphorylation pathway. In lysed cell preparations, Mn2+ stimulated also phosphorylation of a different spectrum of proteins to Ca2+, and of the same proteins to different extents. In particular, P80 (MARCKS protein) was more intensely phosphorylated in the presence of Mn2+ than in the presence of Ca2+. Since TOH phosphorylation always occurs when intracellular Ca2+ is increased, the absence of an increase with Mn2+ indicates that none of its intracellular effects could have occurred as a consequence of Mn2+ mobilisation of intracellular Ca2+. In summary, the data show that Mn2+ is a surrogate for Ca2+ in triggering and maintaining catecholamine release, but does not substitute for Ca2+ in stimulating TOH phosphorylation.
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| 1996 |
Broad LM, Powis DA, Taylor CW, 'Differentiation of BC(3)H1 smooth muscle cells changes the bivalent cation selectivity of the capacitative Ca2+ entry pathway', BIOCHEMICAL JOURNAL, 316 759-764 (1996)
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| 1996 |
Powis DA, Clark CL, 'A difference in the cellular mechanisms of secretion of adrenaline and noradrenaline revealed with lanthanum in bovine chromaffin cells', NEUROSCIENCE LETTERS, 203 131-134 (1996)
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| 1996 |
Powis DA, Clark CL, OBrien KJ, 'Depleted internal store-activated Ca2+ entry can trigger neurotransmitter release in bovine chromaffin cells', NEUROSCIENCE LETTERS, 204 165-168 (1996)
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| 1996 |
Powis DA, Clark CL, OBrien KJ, 'Depleted internal store-activated Ca2+ entry can trigger neurotransmitter release in bovine chromaffin cells (vol 204, pg 165, 1996)', NEUROSCIENCE LETTERS, 210 74-74 (1996)
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| 1995 |
ROLFE IE, ANDREN JM, PEARSON S, HENSLEY MJ, GORDON JJ, 'CLINICAL COMPETENCE OF INTERNS', MEDICAL EDUCATION, 29 225-230 (1995)
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| 1995 |
BROAD LM, POWIS DA, TAYLOR CW, 'DIFFERENTIATION OF MOUSE BC3H1 SMOOTH-MUSCLE CELLS CHANGES THE BIVALENT CATION SELECTIVITY OF THE CAPACITATIVE CA2+ ENTRY PATHWAY', JOURNAL OF PHYSIOLOGY-LONDON, 487P P22-P23 (1995) |
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| 1995 |
ROLFE IE, PEARSON S, POWIS DA, SMITH AJ, 'TIME FOR A REVIEW OF ADMISSION TO MEDICAL-SCHOOL', LANCET, 346 1329-1333 (1995)
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| 1994 |
Smith AJ, Barnsley L, Cameron R, Engel CE, Feletti GI, Hazell P, et al., 'Ratings of Performance of Graduates from Traditional and Nontraditional Medical Schools', Teaching and Learning in Medicine, 6 179-184 (1994)
We compared clinical supervisors¿ ratings of intern competence in Newcastle University graduates (whose medical school emphasizes community relevance and interpersonal skills) and... [more] We compared clinical supervisors¿ ratings of intern competence in Newcastle University graduates (whose medical school emphasizes community relevance and interpersonal skills) and in medical graduates of the Universities of Sydney and New South Wales, which have more traditional curricula. A 12-item anchored supervisor rating scale was used to assess the professional competence of 428 interns on five occasions throughout the intern year. Data analysis was performed using two factors of clinical competence and personal characteristics, as well as an average annual total score. linear regression analysis was employed to estimate the adjusted effects of age, sex, and graduating university on the three scores. All three scores were higher for interns who graduated at younger than 25 years, irrespective of university of graduation or sex. Women scored higher on average than men, and Newcastle graduates were rated significantly better on average than Sydney University graduates for the personal characteristics scores. At the beginning of the intern year, Newcastle graduates had higher total scores than graduates from the two other medical schools. By the end of the intern year, there was no difference in total scores for the three universities. The results of this study suggest that age, sex, and curriculum background are factors influencing aspects of performance at entry to the internship year and also the professional development of interns throughout that year. © 1994, Taylor & Francis Group, LLC. All rights reserved.
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| 1994 |
POWIS DA, CLARK CL, OBRIEN KJ, 'LANTHANUM CAN BE TRANSPORTED BY THE SODIUM-CALCIUM EXCHANGE PATHWAY AND DIRECTLY TRIGGERS CATECHOLAMINE RELEASE FROM BOVINE CHROMAFFIN CELLS', CELL CALCIUM, 16 377-390 (1994)
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| 1994 |
POWIS DA, 'SELECTING MEDICAL-STUDENTS', MEDICAL EDUCATION, 28 443-469 (1994)
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| 1993 |
HILL CE, POWIS DA, HENDRY IA, 'INVOLVEMENT OF PERTUSSIS-TOXIN-SENSITIVE AND TOXIN-INSENSITIVE MECHANISMS IN ALPHA-ADRENOCEPTOR MODULATION OF NORADRENALINE RELEASE FROM RAT SYMPATHETIC NEURONS IN TISSUE-CULTURE', BRITISH JOURNAL OF PHARMACOLOGY, 110 281-288 (1993)
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| 1993 |
POWIS DA, BRISTOW T, 'IMPROVING ACCESS TO MEDICAL COURSES IN AUSTRALIA FOR STUDENTS FROM GEOGRAPHICALLY ISOLATED AREAS', MEDICAL JOURNAL OF AUSTRALIA, 159 429-429 (1993)
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| 1992 |
POWIS DA, WARING TC, BRISTOW T, OCONNELL DL, 'THE STRUCTURED INTERVIEW AS A TOOL FOR PREDICTING PREMATURE WITHDRAWAL FROM MEDICAL-SCHOOL', AUSTRALIAN AND NEW ZEALAND JOURNAL OF MEDICINE, 22 692-698 (1992)
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| 1992 |
BUNN SJ, OBRIEN KJ, BOYD TL, POWIS DA, 'PERTUSSIS TOXIN INHIBITS NORADRENALINE ACCUMULATION BY BOVINE ADRENAL-MEDULLARY CHROMAFFIN CELLS', NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 346 649-656 (1992)
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| 1992 |
NEAME RLB, POWIS DA, BRISTOW T, 'SHOULD MEDICAL-STUDENTS BE SELECTED ONLY FROM RECENT SCHOOL-LEAVERS WHO HAVE STUDIED SCIENCE', MEDICAL EDUCATION, 26 433-440 (1992)
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| 1992 |
KAVANAGH JM, POWIS DA, DODD PR, ROSTAS JAP, 'NMDA RECEPTOR FUNCTION IN CHICKEN FOREBRAIN DURING MATURATION', MOLECULAR NEUROPHARMACOLOGY, 2 193-195 (1992)
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| 1992 |
Powis DA, McManus IC, Cleave-Hoeg D, 'Selection of Medical Students: Philosophic, Political, Social, and Educational Bases', Teaching and Learning in Medicine, 4 25-34 (1992)
The task of selecting a cohort of medical students from a pool of well-qualified applicants is complex and fraught with ethical dilemmas and organizational difficulties. In this a... [more] The task of selecting a cohort of medical students from a pool of well-qualified applicants is complex and fraught with ethical dilemmas and organizational difficulties. In this article, we identify and attempt to formalize the constraints on the task. In response to a range of pressures (or influences) a medical school creates a selection policy, in which selectors define the ¿necessary characteristics¿ of medical school entrants, such as their personal qualities, aptitudes, demography, and so forth. Implementation of that selection policy then involves choosing a range of selection processes or techniques which can be used to find those candidates within the pool of applicants who satisfy a range of ¿selectable characteristics.¿ Evaluation of the success of the selection policy involves comparison of the selectable characteristics with the necessary characteristics; this essential step can be used iteratively to achieve eventual congruence between selection policy and selection process. Also in this article, we give specific examples of the pressures that school may be subject to, the characteristics that are selectable, and the processes that may be used, and we consider the implications of various selection processes for those selection policies. © 1992, Taylor & Francis Group, LLC. All rights reserved.
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| 1991 |
POWIS DA, OBRIEN KJ, 'ANGIOTENSIN-II INCREASES CATECHOLAMINE RELEASE FROM BOVINE ADRENAL-MEDULLA BUT DOES NOT ENHANCE THAT EVOKED BY K+ DEPOLARIZATION OR BY CARBACHOL', JOURNAL OF NEUROCHEMISTRY, 57 1461-1469 (1991)
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| 1991 |
POWIS DA, OBRIEN KJ, VONGRAFENSTEIN HRK, 'CALCIUM EXPORT BY SODIUM-CALCIUM EXCHANGE IN BOVINE CHROMAFFIN CELLS', CELL CALCIUM, 12 493-504 (1991)
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| 1991 |
ROSTAS JAP, KAVANAGH JM, DODD PR, HEATH JW, POWIS DA, 'MECHANISMS OF SYNAPTIC PLASTICITY - CHANGES IN POSTSYNAPTIC DENSITIES AND GLUTAMATE RECEPTORS IN CHICKEN FOREBRAIN DURING MATURATION', MOLECULAR NEUROBIOLOGY, 5 203-216 (1991)
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| 1991 |
POWIS DA, 'COMPONENTS OF TRANSMEMBRANE POTASSIUM (RB-86(+)) FLUX DURING EVOKED TENSION DEVELOPMENT IN DOG SAPHENOUS-VEIN - CONTRIBUTION OF THE NA+-K+ PUMP', EXPERIMENTAL PHYSIOLOGY, 76 423-436 (1991)
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| 1990 |
TOROK TL, POWIS DA, 'CATECHOLAMINE RELEASE FROM BOVINE CHROMAFFIN CELLS - THE ROLE OF SODIUM CALCIUM EXCHANGE IN OUABAIN-EVOKED RELEASE', EXPERIMENTAL PHYSIOLOGY, 75 573-586 (1990)
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| 1989 |
VONGRAFENSTEIN HRK, POWIS DA, 'CALCIUM IS RELEASED BY EXOCYTOSIS TOGETHER WITH CATECHOLAMINES FROM BOVINE ADRENAL-MEDULLARY CELLS', JOURNAL OF NEUROCHEMISTRY, 53 428-435 (1989)
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| 1989 |
POWIS DA, 'SODIUM-CALCIUM EXCHANGE IN CULTURED BOVINE CHROMAFFIN CELLS', JOURNAL OF PHYSIOLOGY-LONDON, 418 P182-P182 (1989)
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| 1989 |
SMITH AJ, POWIS DA, 'THE POLITICS OF THE SAND-PIT', MEDICAL JOURNAL OF AUSTRALIA, 150 543-544 (1989)
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| 1989 |
POWIS DA, OBRIEN KJ, TOROK TL, 'MULTIPLE EFFECTS OF COCAINE UPON EVOKED SECRETION IN BOVINE ADRENAL-MEDULLARY CHROMAFFIN CELLS - ADDITIONAL INSIGHT INTO THE MECHANISM OF ACTION OF CARDIAC-GLYCOSIDES', NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 339 272-280 (1989)
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| 1989 |
TOROK TL, RACZ D, TOTH PT, AZZIDANI AM, POWIS DA, MAGYAR K, 'A-23187 EVOKED TRANSMITTER RELEASE FROM RABBIT PULMONARY-ARTERY AND ITS INHIBITION BY REACTIVATION OF SODIUM-PUMP', GENERAL PHARMACOLOGY, 20 421-425 (1989)
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| 1989 |
TOROK TL, PAULO T, TOTH PT, AZZIDANI AM, POWIS DA, MAGYAR K, 'SODIUM-AZIDE-EVOKED NORADRENALINE AND CATECHOLAMINE RELEASE FROM PERIPHERAL SYMPATHETIC-NERVES AND CHROMAFFIN CELLS', GENERAL PHARMACOLOGY, 20 143-149 (1989)
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| 1988 |
WAN DCC, POWIS DA, MARLEY PD, LIVETT BG, 'EFFECTS OF ALPHA-ADRENOCEPTOR AND BETA-ADRENOCEPTOR AGONISTS AND ANTAGONISTS ON ATP AND CATECHOLAMINE RELEASE AND DESENSITIZATION OF THE NICOTINIC RESPONSE IN BOVINE ADRENAL CHROMAFFIN CELLS', BIOCHEMICAL PHARMACOLOGY, 37 725-736 (1988)
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| 1988 |
CULLCANDY SG, MATHIE A, POWIS DA, 'ACETYLCHOLINE-RECEPTOR CHANNELS AND THEIR BLOCK BY CLONIDINE IN CULTURED BOVINE CHROMAFFIN CELLS', JOURNAL OF PHYSIOLOGY-LONDON, 402 255-278 (1988)
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| 1988 |
POWIS DA, MADSEN GM, TOROK TL, 'AUGMENTATION OF THE INDIRECT SYMPATHOMIMETIC ACTION OF TYRAMINE BY CARDIOACTIVE STEROIDS IS A CONSEQUENCE OF ELEVATED INTRACELLULAR SODIUM', NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 337 273-278 (1988)
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| 1988 |
POWIS DA, NEAME RLB, BRISTOW T, MURPHY LB, 'THE OBJECTIVE STRUCTURED INTERVIEW FOR MEDICAL-STUDENT SELECTION', BRITISH MEDICAL JOURNAL, 296 765-768 (1988)
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| 1988 |
POWIS DA, NEAME RLB, BRISTOW T, MURPHY LB, 'INTERVIEW FOR MEDICAL-STUDENT SELECTION - REPLY', BRITISH MEDICAL JOURNAL, 296 1261-1261 (1988)
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| 1987 |
POWIS DA, 'ALPHA-2-ADRENOCEPTOR BLOCKADE PREVENTS CARDIAC GLYCOSIDE-EVOKED NEUROTRANSMITTER RELEASE FROM SYMPATHETIC-NERVES IN DOG SAPHENOUS-VEIN', BRITISH JOURNAL OF PHARMACOLOGY, 92 213-220 (1987)
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| 1987 |
Powis DA, 'a
The effect of a-adrenoceptor antagonists upon neurotransmitter release evoked by cardiac glycosides from sympathetic nerve terminals has been investigated in dog saphenous vein. I... [more] The effect of a-adrenoceptor antagonists upon neurotransmitter release evoked by cardiac glycosides from sympathetic nerve terminals has been investigated in dog saphenous vein. In rings of saphenous vein preloaded with [3H]-noradrenaline, acetylstrophanthidin (ACS) caused a concentration-dependent efflux of 3H (EC50 ca. 4.4 µm) that was attenuated by phentolamine and yohimbine but not by prazosin. In helical strips of saphenous vein superfused with ACS at EC50 the efflux of 3H-compounds in general, and of [3H]-noradrenaline in particular, occurred after a short delay and increased with time to a maximum reached at 75 min. Phentolamine and phenoxybenzamine, but not prazosin reduced the efflux of [3H]-noradrenaline and of total 3H-compounds throughout the time-course of the ACS-evoked effect. In helical strips of saphenous vein the glycoside ouabain also caused an increase in [3H]-noradrenaline and in total 3H-efflux that was attenuated by phentolamine. By contrast with the above, in bovine adrenal medullary chromaffin cells, which appear to have no functional a-adrenoceptors, ACS caused a small, but significant increase in 3H-efflux which was not prevented by phentolamine. Phentolamine, at concentrations that attenuate markedly the ouabain-or ACS-evoked increase in 3H-efflux from dog saphenous vein, did not cause significant inhibition of cocaine-sensitive [3H]-noradrenaline uptake nor did it reduce the extent of the 3H-efflux evoked either by tyramine or by reduced extracellular Na+. These findings imply that phentolamine does not affect ACS-evoked neurotransmitter release by an action on the catecholamine uptake mechanism. It is concluded that the cardiac glycoside-evoked increase in neurotransmitter release from noradrenergic nerve terminals of dog saphenous vein is modulated by a mechanism that involves an a2-adrenoceptor. 1987 British Pharmacological Society
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| 1986 |
Powis DA, Madsen GM, 'Unsuitability of the
(Na+ + K+)-ATPase activity was estimated by 86Rb+ uptake in dog saphenous vein to determine the validity of the technique in tissues that have a sympathetic innervation. When saph... [more] (Na+ + K+)-ATPase activity was estimated by 86Rb+ uptake in dog saphenous vein to determine the validity of the technique in tissues that have a sympathetic innervation. When saphenous vein rings were incubated at 37°C in Krebs' solution containing 86Rb+, the cardenolide acetylstrophanthidin caused a concentration-dependent inhibition of Rb+ uptake. The threshold for inhibition was approx. 10 nM acetylstrophanthidin and the maximum effect was obtained at 9 µM. In the upper part of this concentration range (> 1 µM) acetylstrophanthidin released noradrenaline from the sympathetic nerve terminals associated with the tissue. In this upper part of the acetylstrophanthidin concentration range the a-adrenoceptor antagonist phentolamine (8 µM) reduced, by up to 25%, the degree of 86Rb+ uptake inhibition caused by the cardenolide. In other experiments, saphenous vein strips were loaded with 86Rb+ and perifused with Krebs' solution containing acetylstrophanthidin. At concentrations which release noradrenaline, acetylstrophanthidin increased the efflux of 86Rb+. Phentolamine (8 µM) prevented the acetylstrophanthidin-evoked efflux of the isotope as did prior in vitro denervation of 86Rb+ loaded strips with 6-hydroxydopamine. Exogenous noradrenaline (1-100 µM) added to the perifusing fluid also caused an efflux of 86Rb+ that was attenuated by phentolamine. The data indicate for dog saphenous vein that with low concentrations of acetylstrophanthidin the extent of 86Rb+ accumulation might accurately reflect prevailing (Na+ + K+)-ATPase activity. At higher concentrations of acetylstrophanthidin, however, noradrenaline is released from the nerve endings and causes 86Rb+ efflux from the smooth muscle cells consequent upon a-adrenoceptor activation. Since this efflux reduces the extent of Rb+ accumulation, measurement of the latter does not adequately reflect uptake mediated by the activity of (Na+ + K+)-ATPase. This is significant because in most applications of the 86Rb+ uptake method it is the estimate of Rb+ accumulation made in the presence of a high concentration of cardenolide that forms the basis of all subsequent calculations with respect to (Na+ + K+)- ATPase activity. © 1986.
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| 1986 |
POWIS DA, MADSEN GM, 'UNSUITABILITY OF THE RB-86(+) UPTAKE METHOD FOR ESTIMATION OF (NA+ + K+)-ATPASE ACTIVITY IN INNERVATED TISSUES', BIOCHIMICA ET BIOPHYSICA ACTA, 861 251-258 (1986)
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| 1986 |
CULLCANDY SG, MATHIE A, POWIS DA, 'INFLUENCE OF THE ALPHA-ADRENOCEPTOR AGONIST CLONIDINE ON SINGLE ACETYLCHOLINE-RECEPTOR CHANNELS IN BOVINE CHROMAFFIN CELLS', JOURNAL OF PHYSIOLOGY-LONDON, 371 P157-P157 (1986)
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| 1986 |
POWIS DA, BAKER PF, 'ALPHA-2-ADRENOCEPTORS DO NOT REGULATE CATECHOLAMINE SECRETION BY BOVINE ADRENAL-MEDULLARY CELLS - A STUDY WITH CLONIDINE', MOLECULAR PHARMACOLOGY, 29 134-141 (1986)
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| 1986 |
POWIS DA, MADSEN GM, 'ALPHA-ADRENOCEPTOR-MEDIATED INCREASE IN TENSION AND EFFLUX OF RB-86 IN DOG SAPHENOUS-VEIN', BLOOD VESSELS, 23 95-96 (1986)
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| 1986 |
ROSTAS JAP, BRENT VA, HEATH JW, NEAME RLB, POWIS DA, WEINBERGER RP, DUNKLEY PR, 'THE SUBCELLULAR-DISTRIBUTION OF A MEMBRANE-BOUND CALMODULIN-STIMULATED PROTEIN-KINASE', NEUROCHEMICAL RESEARCH, 11 253-268 (1986)
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| 1986 |
Powis DA, Baker PF, 'a
Experiments have been performed with perfused bovine adrenal glands, with freshly isolated chromaffin cells, and with chromaffin cells maintained in tissue culture to investigate ... [more] Experiments have been performed with perfused bovine adrenal glands, with freshly isolated chromaffin cells, and with chromaffin cells maintained in tissue culture to investigate the suggestion that there are a-adrenoceptors present which regulate catecholamine secretion. Only one set of observations has lent support to this suggestion: the rather specific a2-adrenoceptor agonist clonidine inhibits catecholamine secretion evoked by the physiological secretogogue, acetylcholine, and by the related nicotinic agonists, carbachol and nicotine. All other observations detract from this suggestion. Other a-adrenoceptor agonists (noradrenaline, adrenaline, tramazoline, phenylephrine, and a-methyl-noradrenaline) are virtually ineffective at inhibiting secretion evoked by carbachol. In addition, the a-adrenoceptor antagonists phentolamine, phenoxybenzamine, and yohimbine not only fail to enhance the secretion of catecholamines evoked by carbachol but also fail to offset the inhibitory action of clonidine. The data suggest that functional a2-adrenoceptors of the classical type are not present upon bovine chromaffin cells and that, in this tissue, clonidine must act in some other way. In the bovine adrenal medullary chromaffin cell clonidine probably acts at the nicotinic receptor because it does not reduce catecholamine secretion evoked by depolarizing concentrations of potassium or veratridine but does reduce the carbachol-evoked influx of 22Na that can be measured in the presence of tetrodotoxin and ouabain and which probably reflects entry through the nicotinic channel. Furthermore, clonidine can abolish, in reversible fashion, the acetylcholine-activated inward current determined with patch-clamp.
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| 1985 |
POWIS DA, 'FAILURE OF CALCIUM TO STIMULATE NA,K-ATPASE IN THE PRESENCE OF EDTA', EXPERIENTIA, 41 1048-1051 (1985)
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| 1985 |
VONGRAFENSTEIN HRK, POWIS DA, 'EXOCYTOSIS AS AN EXPORT ROUTE FOR CALCIUM FROM BOVINE CHROMAFFIN CELLS', JOURNAL OF PHYSIOLOGY-LONDON, 358 P66-P66 (1985) |
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| 1985 |
POWIS DA, 'CLONIDINE INHIBITS CATECHOLAMINE RELEASE FROM BOVINE ADRENAL-MEDULLARY CELLS BUT APPARENTLY NOT VIA ALPHA-2-ADRENOCEPTORS', JOURNAL OF PHYSIOLOGY-LONDON, 358 P87-P87 (1985)
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| 1985 |
TAN CM, POWIS DA, 'CARDIAC-GLYCOSIDES, CALCIUM AND THE RELEASE OF NEUROTRANSMITTER FROM PERIPHERAL NORADRENERGIC NERVES', NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 329 1-8 (1985)
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| 1985 |
POWIS DA, 'THE EFFECT OF COOLING ON THE RESPONSES OF SPLENIC CAPSULAR AND VASCULAR SMOOTH-MUSCLE TO NERVE-STIMULATION IN THE DOG', PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 403 334-336 (1985)
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| 1983 |
POWIS DA, 'CARDIAC-GLYCOSIDES AND AUTONOMIC NEUROTRANSMISSION', JOURNAL OF AUTONOMIC PHARMACOLOGY, 3 127-154 (1983)
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| 1983 |
POWIS DA, ANDERSON TA, JACKSON H, WATTUS GD, 'STIMULATION OF NEURONAL NA+,K+-ATPASE BY CALCIUM', BIOCHEMICAL PHARMACOLOGY, 32 1219-1227 (1983)
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| 1983 |
TAN CM, POWIS DA, 'CARDIAC-GLYCOSIDES, CALCIUM AND THE RELEASE OF NEUROTRANSMITTER FROM PERIPHERAL NORADRENERGIC NERVES', BIOCHEMICAL PHARMACOLOGY, 32 3491-3494 (1983)
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| 1981 |
POWIS DA, 'DOES NA,K-ATPASE PLAY A ROLE IN THE REGULATION OF NEUROTRANSMITTER RELEASE BY PREJUNCTIONAL ALPHA-ADRENOCEPTORS', BIOCHEMICAL PHARMACOLOGY, 30 2389-2397 (1981)
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| 1981 |
POWIS DA, WATTUS GD, 'THE STIMULATORY EFFECT OF CALCIUM ON NA,K-ATPASE OF NERVOUS-TISSUE', FEBS LETTERS, 126 285-288 (1981)
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| 1981 |
NEAME RLB, POWIS DA, 'TOWARD INDEPENDENT LEARNING - CURRICULAR DESIGN FOR ASSISTING STUDENTS TO LEARN HOW TO LEARN', JOURNAL OF MEDICAL EDUCATION, 56 886-893 (1981)
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| 1981 |
POWIS DA, NEAME RLB, 'THE WAY WE TEACH - THE CARDIOVASCULAR-SYSTEM', MEDICAL TEACHER, 3 131-137 (1981)
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| 1981 |
Powis DA, Neame RLB, 'The cardiovascular system', Medical Teacher, 3 131-137 (1981)
In the last issue of this journal an approach to the construction of integrated, multidisciplinary course units was described (Neame 1981). This approach is illustrated in relatio... [more] In the last issue of this journal an approach to the construction of integrated, multidisciplinary course units was described (Neame 1981). This approach is illustrated in relation to the cardiovascular system course unit developed for use early in the second year of the five-year curriculum at the Faculty of Medicine, The University of Newcastle, New South Wales. © 1981 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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| 1981 |
Neame RL, Powis DA, 'Toward independent learning: Curricular design for assisting students to learn how to learn', Academic Medicine, 56 886-893 (1981)
It must be acknowledged that a university course in medicine cannot hope to present its students with everything they need to know in order to practice a lifetime's career in... [more] It must be acknowledged that a university course in medicine cannot hope to present its students with everything they need to know in order to practice a lifetime's career in the profession. Even were the course years longer, increasing the content of factual knowledge would not equip the graduate for the practice of medicine. In part this is due to the fact that medical knowledge is continually changing or being reevaluated; in addition, facts alone cannot be correlated with practical application, and the process of how to use the facts is an essential part of the study and practice of medicine. It is essential, therefore, that an undergraduate medical course, among other things, teach the students to take responsibility for and to be able to structure their own learning. If the process of continual active learning is fostered during undergraduate days, it may readily be continued by the graduate alone in the absence of his teachers. The curriculum at the new medical school at Newcastle, New South Wales, Australia, is being developed with this priority in view. This paper describes some of the principles underpinning this philosophy and how such principles are being applied. © 1981 Association of American Medical Colleges.
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| 1980 |
LORENZ RR, POWIS DA, VANHOUTTE PM, SHEPHERD JT, 'THE EFFECTS OF ACETYLSTROPHANTHIDIN AND OUABAIN ON THE SYMPATHETIC ADRENERGIC NEUROEFFECTOR JUNCTION IN CANINE VASCULAR SMOOTH-MUSCLE', CIRCULATION RESEARCH, 47 845-854 (1980)
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| 1980 |
POWIS DA, WATTUS GD, 'INVOLVEMENT OF NA, K-ATPASE IN THE ALPHA-ADRENOCEPTOR MEDIATED NORADRENALINE RELEASE REGULATION MECHANISM OF SYMPATHETIC-NERVES', BLOOD VESSELS, 17 159-159 (1980) |
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| 1979 |
IMMS FJ, NEAME RLB, POWIS DA, 'SUBDIVISION OF BETA-ADRENOCEPTORS IN THE CARDIOVASCULAR-SYSTEM OF THE RAT', BRITISH JOURNAL OF PHARMACOLOGY, 67 367-370 (1979)
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| 1979 |
LORENZ RR, POWIS DA, SHEPHERD JT, 'MODE OF ACTION OF ACETYLSTROPHANTHIDIN ON SYMPATHETIC-NERVE TERMINALS IN VASCULAR SMOOTH-MUSCLE', CIRCULATION, 60 198-198 (1979) |
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| 1979 |
LORENZ RR, POWIS DA, SHEPHERD JT, 'PREJUNCTIONAL ALPHA-ADRENOCEPTORS IN VASCULAR SMOOTH-MUSCLE', BLOOD VESSELS, 16 217-217 (1979) |
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| 1979 |
NEAME RLB, POWIS DA, IMMS FJ, 'CARDIOVASCULAR EFFECTS OF HYPOXIA IN ADRENAL INSUFFICIENCY IN RATS', ANAESTHESIA AND INTENSIVE CARE, 7 81-82 (1979) |
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| 1979 |
Powis DA, Donald DE, 'Involvement of renal alpha- and beta-adrenoceptors in release of renin by carotid baroreflex.', The American journal of physiology, 236 (1979)
In anesthetized vagotomized dogs with renal arterial pressure constant, carotid sinus hypotension (BCO) caused a reflex rise in systemic arterial pressure, a fall in renal blood f... [more] In anesthetized vagotomized dogs with renal arterial pressure constant, carotid sinus hypotension (BCO) caused a reflex rise in systemic arterial pressure, a fall in renal blood flow, and a similar increase in renin release from both kidneys. Unilateral alpha-adrenoceptor blockade with phenoxybenzamine resulted in an increase in basal renal blood flow, a depression of basal renin release, and an abolition of the responses to BCO in the treated kidney. The untreated kidney responsed to BCO as before. Nonblocked and alpha-blocked kidneys released similar amounts of renin when renal blood flow was mechanically reduced by aortic constriction. Administration of propranolol to the nonblocked kidney prevented the release of renin but not the hemodynamic changes resulting from BCO. The experiments demonstrated that under certain conditions carotid sinus hypotension produced alpha-adrenoceptor-mediated changes in the kidney sufficient to cause increased renin release. A step in the renin release mechanism subsequent to the alpha-adrenoceptor-mediated changes in sensitive to propranolol.
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| 1979 |
Powis DA, Donald DE, 'Involvement of renal a- and ß-adrenoceptors in release of renin by carotid baroreflex', American Journal of Physiology - Heart and Circulatory Physiology, 5 (1979)
In anesthetized vagotomized dogs with renal arterial pressure constant, carotid sinus hypotension (BCO) caused a reflex rise in systemic arterial pressure, a fall in renal blood f... [more] In anesthetized vagotomized dogs with renal arterial pressure constant, carotid sinus hypotension (BCO) caused a reflex rise in systemic arterial pressure, a fall in renal blood flow, and a similar increase in renin release from both kidneys. Unilateral a-adrenoceptor blockade with phenoxybenzamine resulted in an increase in basal renal blood flow, a depression of basal renin release, and an abolition of the responses to BCO in the treated kidney. The untreated kidney responded to BCO as before. Nonblocked and a-blocked kidneys released similar amounts of renin when renal blood flow was mechanically reduced by aortic constriction. Administration of propranolol to the nonblocked kidney prevented the release of renin but not the hemodynamic changes resulting from BCO. The experiments demonstrated that under certain conditions carotid sinus hypotension produced a-adrenoceptor-mediated changes in the kidney sufficient to cause increased renin release. A step in the renin release mechanism subsequent to the a-adrenoceptor-mediated changes is sensitive to propranolol.
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| 1978 |
DAVIES BN, POWIS DA, WITHRINGTON PG, 'DIFFERENTIAL EFFECT OF COOLING ON RESPONSES OF SPLENIC CAPSULAR AND VASCULAR SMOOTH-MUSCLE TO NERVE-STIMULATION AND NORADRENALINE', PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 377 87-94 (1978)
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| 1978 |
Lorenz RR, Powis DA, Shepherd JT, 'Effect of acetylstrophanthidin on adrenergic neurotransmission in vascular smooth muscle', Federation Proceedings, 37 (1978) |
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| 1977 |
IMMS FJ, NEAME RLB, POWIS DA, 'RESPONSES OF CARDIOVASCULAR-SYSTEM OF RAT TO ALPHA-ADRENOCEPTOR AND BETA-ADRENOCEPTOR AGONISTS', BRITISH JOURNAL OF PHARMACOLOGY, 60 107-114 (1977)
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| 1977 |
IMMS FJ, NEAME RLB, POWIS DA, 'RESPONSES OF CARDIOVASCULAR-SYSTEM OF RAT TO NORADRENALINE INFUSIONS AND THEIR MODIFICATION BY ADRENOCEPTOR BLOCKING-AGENTS', BRITISH JOURNAL OF PHARMACOLOGY, 60 115-122 (1977)
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| 1977 |
IMMS FJ, NEAME RLB, POWIS DA, 'SUBDIVISION OF BETA-ADRENOCEPTORS IN CARDIOVASCULAR-SYSTEM OF RAT', JOURNAL OF PHYSIOLOGY-LONDON, 268 P20-P21 (1977) |
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| 1977 |
NEAME RLB, POWIS DA, IMMS FJ, 'CONSTRUCTION OF THERMISTOR PROBES SUITABLE FOR ESTIMATION OF CARDIAC-OUTPUT BY THERMODILUTION METHOD IN SMALL ANIMALS', MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING, 15 43-48 (1977)
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| 1976 |
POWIS DA, RICHARDSON PDI, 'EFFECTS OF NASAL STIMULATION ON SMALL INTESTINAL VASCULATURE OF ANESTHETIZED CAT', JOURNAL OF PHYSIOLOGY-LONDON, 254 P53-P54 (1976) |
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| 1976 |
NEAME RLB, POWIS DA, 'METHOD FOR CONSTRUCTION OF MINIATURE THERMAL PROBES SUITABLE FOR USE IN SMALL MAMMALS', JOURNAL OF PHYSIOLOGY-LONDON, 259 P6-P7 (1976) |
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| 1976 |
ALLISON DJ, POWIS DA, 'EARLY AND LATE HIND-LIMB VASCULAR-RESPONSES TO STIMULATION OF RECEPTORS IN NOSE OF RABBIT', JOURNAL OF PHYSIOLOGY-LONDON, 262 301-317 (1976)
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| 1976 |
IMMS FJ, NEAME RLB, POWIS DA, 'PARADOXICAL RISE IN BLOOD-PRESSURE DURING PROPRANOLOL TREATMENT', BRITISH MEDICAL JOURNAL, 1 218-219 (1976)
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| 1976 |
Imms FJ, Powis DA, 'Letter: Paradoxical Rise In Blood Pressure During Propranolol Treatment', British Medical Journal, 1 218-219 (1976)
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| 1975 |
IMMS FJ, NEAME RLB, POWIS DA, 'SYMPATHETIC NERVOUS ACTIVITY AFTER ADRENALECTOMY IN RAT', JOURNAL OF ENDOCRINOLOGY, 64 P2-P3 (1975) |
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| 1975 |
ANGELLJAMES JE, POWIS DA, 'ADRENAL WEIGHT AND CATECHOLAMINE CONTENT IN RENAL AND CALCIFEROL-INDUCED HYPERTENSION IN RABBITS', CLINICAL SCIENCE AND MOLECULAR MEDICINE, 49 183-186 (1975)
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| 1974 |
POWIS DA, 'COMPARISON OF EFFECTS OF STIMULATION OF SYMPATHETIC VASOMOTOR NERVES AND ADRENAL MEDULLARY CATECHOLAMINES ON HIND LIMB BLOOD-VESSELS OF RABBIT', JOURNAL OF PHYSIOLOGY-LONDON, 240 135-151 (1974)
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| 1974 |
IMMS FJ, NEAME RLB, POWIS DA, 'EFFECTS OF BETA-ADRENERGIC-BLOCKADE UPON CARDIOVASCULAR-RESPONSES OF RAT TO NORADRENALINE INFUSIONS', JOURNAL OF PHYSIOLOGY-LONDON, 241 P47-P49 (1974)
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| 1971 |
DAVIES BN, POWIS DA, WITHRINGTON PG, 'EFFECTS OF LOWERED TEMPERATURE ON RESPONSES OF SMOOTH MUSCLE OF ISOLATED, BLOOD-PERFUSED DOGS SPLEEN TO SYMPATHETIC NERVE STIMULATION', JOURNAL OF PHYSIOLOGY-LONDON, 212 P18-+ (1971)
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| 1971 |
ALLISON DJ, POWIS DA, 'ADRENAL CATECHOLAMINE SECRETION DURING STIMULATION OF NASAL MUCOUS MEMBRANE IN RABBIT', JOURNAL OF PHYSIOLOGY-LONDON, 217 327-+ (1971)
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| 1971 |
Vinson GP, Whitehouse BJ, Allison DJ, Powis DA, 'Species variation in adrenocortical function: The secretion of cortisol by normal rabbit adrenal tissue in vivo and in vitro', Journal of Steroid Biochemistry, 2 299-305 (1971)
Using paper, thin layer and gas Chromatographic methods, it was shown that normal rabbit adrenal tissue has the capacity to form and secrete cortisol from endogenous precursors in... [more] Using paper, thin layer and gas Chromatographic methods, it was shown that normal rabbit adrenal tissue has the capacity to form and secrete cortisol from endogenous precursors in vitro, and in vivo under pentobarbitone anaesthesia. The identity of the extracted cortisol was confirmed by gas chromatography/mass spectrometry of 4-androstene-3,11,17-trione formed from the cortisol by chromic acid oxidation. Levels of cortisol in vivo were 21 ± 4µg per 100 ml of whole adrenal vein blood, compared with figures of 155 ± 11µg/100 ml for corticosterone, 18 ± 3µg/100 ml for deoxycorticosterone and 3 ± 1µg/100ml for aldostcrone. Cortisol formed from endogenous precursors in vitro was secreted in slightly higher amounts relative to corticosterone. These findings conflict with those of other authors who have been unable to detect cortisol as a secretion product of the normal rabbit adrenal (although it may be produced by glands maximally stimulated with ACTH). Further experiments showed that in incubations where appreciable amounts of cortisol were formed from endogenous precursors, negligible amounts were produced from radioactive pregnenolone and progesterone. It is suggested that in unstimulated rabbit adrenal tissue incubated in vitro, the radioactive precursors may not penetrate the endogenous precursor pool. © 1971.
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Lynagh M, Kelly B, Horton G, Walker B, Powis D, Bore M, et al., 'Have we got the selection process right? The validity of selection tools for predicting academic performance in the first year of undergraduate medicine', MedEdPublish, 6
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