The University of Newcastle, Australia
Available in 2019

Course handbook

Description

Presents the pathophysiology of altered health states and their management including both pharmacological and non-pharmacological interventions. Specific conditions covered in this course include gastrointestinal and hepatobiliary conditions. The course considers aspects of pharmacy practice including a systematic review of prescription and non-prescription medications and Complementary and Alternate Medicines, which will address the quality use of medicines in the management of these conditions.

The course builds on student's existing knowledge and understanding of physical pharmacy principles and provides students with an understanding of how these principles are applied to the preparation of solid dosage formulations. The stability of these drug products and factors influencing the storage and shelf life of products is included in this course. In considering the formulation of solid dosage formulations and sterile drug products, the clinical application of tablets, capsules and implants will be discussed and expanded upon in this course.

Pharmacokinetic considerations in conditions of the gastrointestinal and hepatobiliary system are covered such as the process of absorption; bioavailability and first pass clearance; and the clearance of substances by the liver.

Application of the knowledge developed in this course will be complemented by clinical skills training.


Availability2019 Course Timetables

Callaghan

  • Semester 2 - 2019

Learning outcomes

On successful completion of the course students will be able to:

1. Describe the pathophysiology and management (pharmacological and non-pharmacological) of gastrointestinal and hepatobiliary conditions.

2. Describe the pathophysiology and management (pharmacological and non-pharmacological) of oral and dental conditions including principles of oral hygiene.

3. Describe the pathophysiology and principles for the treatment of infectious diseases affecting the gastrointestinal tract (gastroenteritis, giardiasis, traveller's diarrhoea, Colorado, campylobacter enteritis, salmonella enteritis, shigellosis, biliary tract infection, intra-abdominal infection, dental infections).

4. Gain an understanding of the signs, symptoms and complications of these common gastrointestinal infections; be aware of the pathogens involved, understand relevant diagnostic tests and be aware of first and second line infective therapy as well as non-pharmacological approaches to the management of these infections.

5. Describe the quality use of medicines' issues surrounding the use of therapeutic agents in the management of these conditions and continue to develop clinical skills and communication skills in the therapeutic management of these conditions.

6. Identify the principles of drug stability and discuss pharmacy practice issues relating to storage of solid oral dosage forms.

7. Describe the formulation and manufacture of solid dosage forms and sterile drug products.

8. Understand the skills required in the preparation of solid pharmaceutical products including tablets and capsules.

9. Describe the role of pharmacodynamics and pharmacokinetic factors as determinants of drug response in gastrointestinal and hepatobiliary conditions.

10. Understand the underlying principles of absorption; bioavailability and first pass clearance; and the clearance of substances by the liver including the concepts of high/low extraction and metabolism.


Content

1. This course will cover the pathophysiology, therapeutic management (pharmacological and non-pharmacological) and pharmacy practice issues in the management of:

- Gastrointestinal conditions (including peptic ulcer disease, reflux, nausea and vomiting and inflammatory bowel disease).

- Hepatobiliary disorders (including cirrhosis, pancreatitis, biliary obstruction).

- Anaemia in the context of Vitamin B12 deficiency.

- Oral and dental health (including dental disorders; periodontal disease; medications used in dental procedures; and oral hygiene).

2. The pathophysiology and principles for the management of the following infectious diseases:

- Gastroenteritis, giardiasis, traveller's diarrhoea, Colorado, campylobacter enteritis, salmonella enteritis, shigellosis, biliary tract infection, intra-abdominal infection.

3. The concept of minor illness and major disease will be discussed, including the use of prescription and non-prescription products, including Complementary and Alternate Medicines. Non-pharmacological approaches to the management of these conditions will also be discussed.

4. The basic underlying principles of good nutrition and healthy eating including supplementation.

5. The course covers advanced concepts in formulation development and design of solid dosage forms including:

- Sterile products, aseptic technique, microbial contamination, spoilage and preservation, principles of sterilisation and storage considerations.

- Dispensing and compounding skills in the preparation of solid dosage forms, including tablets, capsules and implants.

- Factors influencing stability, stability testing and prediction of shelf life including kinetics of chemical decomposition in solution and in the solid state.

6. The course covers all pharmacokinetic considerations for therapeutic agents used in the management of gastrointestinal and hepatobiliary disorders including:

- Principles of absorption; active and passive transport mechanisms and transporter systems/proteins, p-glycoprotein.

- Bioavailability and first pass clearance; an introduction to bioequivalence.

- Clearance of substances by the liver including the concept of high/low extraction and metabolism.

- Genetic variability in pharmacokinetics and pharmacodynamics.


Requisite

This course is only available to students enrolled in the Bachelor of Pharmacy (Honours) program.

Pre-requisite - successful completion of PHAR1101 and PHAR1201


Assumed knowledge

PHAR2203Gastrointestinal Health and Solid Dosage FormulationsPresents the pathophysiology of altered health states and their management including both pharmacological and non-pharmacological interventions. Specific conditions covered in this course include gastrointestinal and hepatobiliary conditions. The course considers aspects of pharmacy practice including a systematic review of prescription and non-prescription medications and Complementary and Alternate Medicines, which will address the quality use of medicines in the management of these conditions.

The course builds on student's existing knowledge and understanding of physical pharmacy principles and provides students with an understanding of how these principles are applied to the preparation of solid dosage formulations. The stability of these drug products and factors influencing the storage and shelf life of products is included in this course. In considering the formulation of solid dosage formulations and sterile drug products, the clinical application of tablets, capsules and implants will be discussed and expanded upon in this course.

Pharmacokinetic considerations in conditions of the gastrointestinal and hepatobiliary system are covered such as the process of absorption; bioavailability and first pass clearance; and the clearance of substances by the liver.

Application of the knowledge developed in this course will be complemented by clinical skills training.FHEALFaculty of Health and Medicine671School of Biomedical Sciences and Pharmacy1020005980Semester 2 - 2019CALLAGHANCallaghan2019PHAR1101 Introduction to Pharmacy and Formulation Sciences, PHAR1201 Introduction to Formulation Sciences or equivalent1. This course will cover the pathophysiology, therapeutic management (pharmacological and non-pharmacological) and pharmacy practice issues in the management of:- Gastrointestinal conditions (including peptic ulcer disease, reflux, nausea and vomiting and inflammatory bowel disease).- Hepatobiliary disorders (including cirrhosis, pancreatitis, biliary obstruction).- Anaemia in the context of Vitamin B12 deficiency.- Oral and dental health (including dental disorders; periodontal disease; medications used in dental procedures; and oral hygiene).2. The pathophysiology and principles for the management of the following infectious diseases:- Gastroenteritis, giardiasis, traveller's diarrhoea, Colorado, campylobacter enteritis, salmonella enteritis, shigellosis, biliary tract infection, intra-abdominal infection.3. The concept of minor illness and major disease will be discussed, including the use of prescription and non-prescription products, including Complementary and Alternate Medicines. Non-pharmacological approaches to the management of these conditions will also be discussed.4. The basic underlying principles of good nutrition and healthy eating including supplementation.5. The course covers advanced concepts in formulation development and design of solid dosage forms including:- Sterile products, aseptic technique, microbial contamination, spoilage and preservation, principles of sterilisation and storage considerations.- Dispensing and compounding skills in the preparation of solid dosage forms, including tablets, capsules and implants.- Factors influencing stability, stability testing and prediction of shelf life including kinetics of chemical decomposition in solution and in the solid state.6. The course covers all pharmacokinetic considerations for therapeutic agents used in the management of gastrointestinal and hepatobiliary disorders including:- Principles of absorption; active and passive transport mechanisms and transporter systems/proteins, p-glycoprotein.- Bioavailability and first pass clearance; an introduction to bioequivalence.- Clearance of substances by the liver including the concept of high/low extraction and metabolism.- Genetic variability in pharmacokinetics and pharmacodynamics. NOn successful completion of this course, students will be able to:1Describe the pathophysiology and management (pharmacological and non-pharmacological) of gastrointestinal and hepatobiliary conditions.2Describe the pathophysiology and management (pharmacological and non-pharmacological) of oral and dental conditions including principles of oral hygiene.3Describe the pathophysiology and principles for the treatment of infectious diseases affecting the gastrointestinal tract (gastroenteritis, giardiasis, traveller's diarrhoea, Colorado, campylobacter enteritis, salmonella enteritis, shigellosis, biliary tract infection, intra-abdominal infection, dental infections).4Gain an understanding of the signs, symptoms and complications of these common gastrointestinal infections; be aware of the pathogens involved, understand relevant diagnostic tests and be aware of first and second line infective therapy as well as non-pharmacological approaches to the management of these infections.5Describe the quality use of medicines' issues surrounding the use of therapeutic agents in the management of these conditions and continue to develop clinical skills and communication skills in the therapeutic management of these conditions.6Identify the principles of drug stability and discuss pharmacy practice issues relating to storage of solid oral dosage forms.7Describe the formulation and manufacture of solid dosage forms and sterile drug products.8Understand the skills required in the preparation of solid pharmaceutical products including tablets and capsules.9Describe the role of pharmacodynamics and pharmacokinetic factors as determinants of drug response in gastrointestinal and hepatobiliary conditions.10Understand the underlying principles of absorption; bioavailability and first pass clearance; and the clearance of substances by the liver including the concepts of high/low extraction and metabolism. This course is only available to students enrolled in the Bachelor of Pharmacy (Honours) program.

Pre-requisite - successful completion of PHAR1101 and PHAR1201Formal Examination: Written exam *Practical Demonstration: Laboratory/Practical assessments *In Term Test: Written Exam -Mid-Term ** This assessment has a compulsory requirement.CallaghanLectureFace to Face On Campus3hour(s)per Week for12Weeks0PracticalFace to Face On Campus3hour(s)per Week for4Weeks0TutorialFace to Face On Campus1hour(s)per Week for12Weeks0In order to pass this course, each student must complete ALL of the following compulsory requirements:General Course Requirements:Practical: Attendance Requirement - Students must attend a minimum number of these sessions.Course Assessment Requirements:Practical Demonstration: Attempt / Submission Requirement - Students must attempt/submit this assessment item to pass the course.In Term Test: Pass Requirement - Students must pass this assessment item to pass the course.Formal Examination: Pass Requirement - Students must pass this assessment item to pass the course.


Assessment items

Formal Examination: Written exam *

Practical Demonstration: Laboratory/Practical assessments *

In Term Test: Written Exam -Mid-Term *

* This assessment has a compulsory requirement.


Compulsory Requirements

In order to pass this course, each student must complete ALL of the following compulsory requirements:

General Course Requirements:

  • Practical: Attendance Requirement - Students must attend a minimum number of these sessions.

Course Assessment Requirements:

  • Practical Demonstration: Attempt / Submission Requirement - Students must attempt/submit this assessment item to pass the course.
  • In Term Test: Pass Requirement - Students must pass this assessment item to pass the course.
  • Formal Examination: Pass Requirement - Students must pass this assessment item to pass the course.

Contact hours

Callaghan

Lecture

Face to Face On Campus 3 hour(s) per Week for 12 Weeks

Practical

Face to Face On Campus 3 hour(s) per Week for 4 Weeks

Tutorial

Face to Face On Campus 1 hour(s) per Week for 12 Weeks