Molecular Organic Synthesis

Course code CHEM3310Units 10Level 3000Faculty of Science and Information TechnologySchool of Environmental and Life Sciences

The development of modern synthetic materials, whether they be new drugs for the treatment of cancer or for the latest synthetic fabric, requires a knowledge of molecular organic synthesis. Students will develop pre-existing skills (from CHEM2310) to a higher level examining a range of synthetic transformations for functional group transformations, carbon-carbon bond formation and skeletal rearrangements, emphasising the chemo- and stereo-selectivity and mechanism of these reactions. A logical, applied approach backed up by laboratory work will be utilised to emphasise key concepts. Students will also be introduced to the application of molecular organic synthesis to biological systems. Selected literature classics of chemical synthesis will also be included.

The course forms part of the accredited degree program required for Membership of Royal Australian Chemical Institute Inc. and Chartered Chemist qualifications.

This course has compulsory course components and students must:
1. must participate in and submit laboratory reports for the established minimum requirements and obtain a minimum passing grade of 50%; and
2. obtain a minimum passing grade of 40% in the final, end-of-semester examination for the course.

In order to participate in this course, students must complete a compulsory Health and Safety requirement. Students will receive full information on this compulsory component in the course outline provided by the school.

Available in 2015

Callaghan CampusSemester 1
Previously offered in 2014
ObjectivesOn successful completion of this course, students will be able:

1. to develop expertise relevant to the professional practice of chemistry
2. to provide a greater understanding of the range and reactions of organic compounds
3. to develop an understanding of the processes of synthesis and mechanisms of reactions in organic chemistry
4. to develop an understanding of the role of the chemist in the synthesis of new compounds and study of their reactions
5. to provide an understanding of the concepts of chemoselectivity and stereoselectivity of organic reactions
6. to provide laboratory experience with some methods employed in organic synthesis
7. to extend skills in procedures applied in synthetic tasks and identification of organic compounds
8. to expand skills in the scientific method of planning, developing, conducting, reviewing and reporting experiments
9. to extend understanding of the professional and safety responsibilities residing in working with organic compounds.
ContentThe course involves study of:

1) Functional Group Chemistry:
a) reactions for functional group transformation
b) nucleophilic addition and substitution at carbonyl groups
c) oxidation-reduction reactions

2) Organic Reaction Mechanisms:
a) mechanisms for organic reactions
b) bond-forming and skeletal rearrangement reactions
c) chemoselectivity and stereoselectivity

3) Synthesis:
a) systematic approaches to synthesis
b) protecting groups
c) multistep synthesis and illustrative examples
Replacing Course(s)NA
TransitionNA
Industrial Experience0
Assumed KnowledgeSuccessful completion of CHEM2310
Modes of DeliveryInternal Mode
Teaching MethodsProblem Based Learning
Lecture
Practical
Tutorial
Assessment Items
Essays / Written Assignments
Examination: FormalThis is a compulsory course component. Students must obtain a minimum passing grade of 40% in the final, end-of-semester examination for the course in order to demonstrate that they have fulfilled course objectives relating to the understanding of the material expounded during lectures and/or described in assigned readings.

On achieving a passing grade, a final mark will be given in the course and it will be recorded that the student has satisfied the compulsory course component. Students who fail to satisfy the compulsory course component will be awarded a zero mark and a FF grade, irrespective of their final numeric mark. In such case, the normal avenues of appeal open to them.
Laboratory ExercisesThis course has a compulsory course component in its laboratory component. Students must participate in and submit reports for the established minimum requirements and obtain a passing grade of at least 50% in order to demonstrate that the student has fulfilled course objectives relating to appropriate laboratory skills and professional and safety responsibilities. On achieving the passing grade, a final mark will be given in the course and it will be recorded that the student satisfied the
compulsory course component. For those students who fail to satisfy the
compulsory course component will have the normal avenues of appeal open to them.

Make-up provisions
Students who are unable to complete the required number of laboratory exercises for reasons beyond their control will be offered the opportunity to make up at least one experiment at the discretion of the Discipline of Chemistry.
Contact HoursLaboratory: for 3 hour(s) per Week for Full Term
Tutorial: for 1 hour(s) per Week for Full Term
Lecture: for 2 hour(s) per Week for Full Term
Compulsory Components
Compulsory Course ComponentIn order to meet course objectives aligned with the students' understanding of, and ability to manipulate and apply the theoretical concepts which form the core of the material expounding during lectures and/or described in assigned readings, students must:
1. must participate in and submit laboratory reports for the established minimum requirements and obtain a minimum passing grade of 50%; and
2. obtain a minimum passing grade of 40% in the final, end-of-semester examination for the course.
Compulsory Course ComponentOHS-Safety Induction or Risk Assessment. In order to participate in this course, students must complete a compulsory safety induction.
Compulsory Program ComponentSuccessful completion of CHEM2310
Timetables2015 Course Timetables for CHEM3310