
Dr Shaun Roman
Senior Lecturer
School of Environmental and Life Sciences (Biological Sciences)
- Email:shaun.roman@newcastle.edu.au
- Phone:(02) 4921 6818
Career Summary
Biography
I am a CI of the Priority Research Centre for Drug Development and a member of the Reproductive Science group at the University of Newcastle. I lead an original research program that is focused on understanding Male Germ Cell Development. This personal niche complements existing research programs in male germ function and ovarian biology within the Reproductive Science Group at the University of Newcastle.
My team is currently addressing the effect of acrylamide on male germ cells. Acrylamide is consumed in food. We have established the detrimental effects of acrylamide and now my team is examining both the consequences of damaging the male germ line and also finding ways to alleviate the effects.
I contribute significant expertise in molecular biology to all programs within the Reproductive Science Group. Consistent with our strategy of being recognised as a leading research-intensive University, I have played an active and successful role in the preparation of grant applications, peer-reviewed publications in high impact journals and presentation at national and international conferences.
In total I have published 2 book chapters and 40 journal articles. I have been a CI on over $17M of competitive research income and $1.5M of equipment grants. Along with Laureate Prof Aitken and Prof McLaughlin, I hold a patent for the tools for germ cell ablation. I have supervised 12 RHD students and 18 Honours students including 4 and 16 as prime supervisor respectively. My students have won awards for their presentations, including at international conferences, and several have been awarded prestigious University or Faculty medals.
I have been a member of the Australian Society for Reproductive Biology since moving to University of Newcastle in 1998 and entering the field of Reproduction. I currently serve on the SRB Council. I have been active in supporting the society in a variety of roles. Since 2007, when I served on the Program Organising Committee, I have reviewed abstracts or been on selection committees for prizes every year.
I review 2-4 grants per annum for the two peak national funding agencies; the ARC and NH&MRC. I perform reviews regularly for many journals. I have recognised media presence and I used as an expert by the Australia Science Media Centre.
I have previously served as an Assistant Dean International & Marketing, a Head of Discipline and a Program Convenor (B Biotech). I am enthusiastic. This is the way I approach science and this leads to strong engagement of RHD students. It is the way I engage undergraduate students in the curriculum.
Qualifications
- PhD, University of New South Wales
- Bachelor of Science, Flinders University
- Bachelor of Science (Honours), Flinders University
Keywords
- Acrylamide
- Cellular Biotechnology
- Gene Expression
- Molecular Biology
- Reproductive Biology
- Signal Transduction
- Spermatogenesis
- Stem Cell Biology
- Toxicology
- Vitamin A metabolism
Fields of Research
Code | Description | Percentage |
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060699 | Physiology not elsewhere classified | 50 |
110199 | Medical Biochemistry and Metabolomics not elsewhere classified | 15 |
060199 | Biochemistry and Cell Biology not elsewhere classified | 35 |
Professional Experience
UON Appointment
Title | Organisation / Department |
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Senior Lecturer | University of Newcastle School of Environmental and Life Sciences Australia |
Academic appointment
Dates | Title | Organisation / Department |
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1/01/2015 - 1/07/2017 | Head of Discipline | University of Newcastle |
1/01/2015 - 1/01/2018 | Assistant Dean International & Marketing | Faculty of Science and Information Technology,The University of Newcastle Australia |
1/05/1999 - 1/12/2004 | Associate Lecturer | University of Newcastle School of Environmental and Life Sciences Australia |
1/06/1998 - 1/05/1999 | Part time Associate Lecturer | University of Newcastle School of Environmental and Life Sciences Australia |
Membership
Dates | Title | Organisation / Department |
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20/09/2016 - | Member of SRB Council | Australian Society for Reproductive Biology Australia |
1/01/2008 - | Member - Aust Society for Medical Research | Australian Society for Medical Research (ASMR) Australia |
1/01/2008 - | Member - Aust Society for Biochemistry & Molecular Biology | Australian Society for Biochemistry and Molecular Biology Australia |
1/01/2007 - 31/12/2007 | Program Organising Committee Member | Australian Society for Reproductive Biology Australia |
Professional appointment
Dates | Title | Organisation / Department |
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1/01/1998 - | Member- Australian Society for Reproductive Biology | Australian Society for Reproductive Biology Australia |
Teaching appointment
Dates | Title | Organisation / Department |
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1/01/2008 - 1/01/2017 | Program Convenor Bachelor of Biotechnology | University of Newcastle |
Invitations
Participant
Year | Title / Rationale |
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2006 |
Cytochrome P450 2E2 Mediates Acrylamide Damage to the Male Germ Line Organisation: Lorne Genome Description: This abstract was chosen for oral presentation at the opening session of the 2006 Lorne Genome Conference. |
2005 |
Science Forum: Endocrine Disruptors: A Human Health Problem? Organisation: Dept of Health and Aging, Office of Chemical Safety Description: Invited to present at briefing session. |
Speaker
Year | Title / Rationale |
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2018 | Environmental toxicants affect the male germ line |
Teaching
Code | Course | Role | Duration |
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BIOL2001 |
Molecular Laboratory Skills for Biological Sciences School of Environmental and Life Sciences, Faculty of Science, The university of Newcastle, Australia Molecular Skills course focusing on biochemistry, immunology and DNA. |
Course Coordinator | 1/01/2006 - 5/08/2049 |
BTEC3251 |
Biotechnology Placement School of Environmental and Life Sciences, Faculty of Science, The university of Newcastle, Australia Students undertake a 10 week full time placement. I coordinate placement. |
Course Coordinator | 1/01/2018 - 5/08/2049 |
BTEC3200 |
Cellular Biotechnology School of Environmental and Life Sciences, Faculty of Science, The university of Newcastle, Australia Students problem solve in groups. |
Course Coordinator | 1/07/1996 - 5/08/2049 |
SCIE3600 |
International Student Experience School of Environmental and Life Sciences, Faculty of Science, The university of Newcastle, Australia Students can undertake an overseas experience. |
Course Coordinator | 1/01/2017 - 5/08/2049 |
BIOL3090 |
Molecular Biology School of Environmental and Life Sciences, Faculty of Science, The university of Newcastle, Australia Third year molecular biology |
Lecturer | 1/01/2003 - 5/08/2049 |
Publications
For publications that are currently unpublished or in-press, details are shown in italics.
Chapter (2 outputs)
Year | Citation | Altmetrics | Link | ||||
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2008 |
Aitken RJ, Roman SD, 'Antioxidant systems and oxidative stress in the testes', Molecular Mechanisms in Spermatogenesis, Landes Bioscience, Austin, Texas 154-171 (2008) [B1]
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2007 |
Aitken RJ, Roman SD, Baker MA, De Iuliis GN, 'Redox regulation of DNA damage in the male germ line', Male-Mediated Developmental Toxicity, Royal Society of Chemistry, London, United Kingdom 197-209 (2007) [B1]
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Journal article (43 outputs)
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2019 |
Xavier MJ, Roman SD, Aitken RJ, Nixon B, 'Transgenerational inheritance: how impacts to the epigenetic and genetic information of parents affect offspring health', HUMAN REPRODUCTION UPDATE, 25 519-541 (2019) [C1]
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2019 |
Ford E, Beckett EL, Roman S, McLaughlin EA, Sutherland J, 'Advances in human primordial follicle activation and premature ovarian insufficiency', Reproduction, (2019)
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2019 |
Xavier MJ, Nixon B, Roman SD, Scott RJ, Drevet JR, Aitken RJ, 'Paternal impacts on development: Identification of genomic regions vulnerable to oxidative DNA damage in human spermatozoa', Human Reproduction, 34 1876-1890 (2019) [C1] © 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For permissions, pleas... [more] © 2019 The Author(s) 2019. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com. STUDY QUESTION: Do all regions of the paternal genome within the gamete display equivalent vulnerability to oxidative DNA damage? SUMMARY ANSWER: Oxidative DNA damage is not randomly distributed in mature human spermatozoa but is instead targeted, with particular chromosomes being especially vulnerable to oxidative stress. WHAT IS KNOWN ALREADY: Oxidative DNA damage is frequently encountered in the spermatozoa of male infertility patients. Such lesions can influence the incidence of de novo mutations in children, yet it remains to be established whether all regions of the sperm genome display equivalent susceptibility to attack by reactive oxygen species. STUDY DESIGN, SIZE, DURATION: Human spermatozoa obtained from normozoospermic males (n = 8) were split into equivalent samples and subjected to either hydrogen peroxide (H2O2) treatment or vehicle controls before extraction of oxidized DNA using a modified DNA immunoprecipitation (MoDIP) protocol. Specific regions of the genome susceptible to oxidative damage were identified by next-generation sequencing and validated in the spermatozoa of normozoospermic males (n = 18) and in patients undergoing infertility evaluation (n = 14). PARTICIPANTS/MATERIALS, SETTING, METHODS: Human spermatozoa were obtained from normozoospermic males and divided into two identical samples prior to being incubated with either H2O2 (5 mm, 1 h) to elicit oxidative stress or an equal volume of vehicle (untreated controls). Alternatively, spermatozoa were obtained from fertility patients assessed as having high basal levels of oxidative stress within their spermatozoa. All semen samples were subjected to MoDIP to selectively isolate oxidized DNA, prior to sequencing of the resultant DNA fragments using a next-generation whole-genomic sequencing platform. Bioinformatic analysis was then employed to identify genomic regions vulnerable to oxidative damage, several of which were selected for real-time quantitative PCR (qPCR) validation. MAIN RESULTS AND THE ROLE OF CHANCE: Approximately 9000 genomic regions, 150-1000 bp in size, were identified as highly vulnerable to oxidative damage in human spermatozoa. Specific chromosomes showed differential susceptibility to damage, with chromosome 15 being particularly sensitive to oxidative attack while the sex chromosomes were protected. Susceptible regions generally lay outside protamine-and histone-packaged domains. Furthermore, we confirmed that these susceptible genomic sites experienced a dramatic (2-15-fold) increase in their burden of oxidative DNA damage in patients undergoing infertility evaluation compared to normal healthy donors. LIMITATIONS, REASONS FOR CAUTION: The limited number of samples analysed in this study warrants external validation, as do the implications of our findings. Selection of male fertility patients was based on high basal levels of oxidative stress within their spermatozoa as opposed to specific sub-classes of male factor infertility. WIDER IMPLICATIONS OF THE FINDINGS: The identification of genomic regions susceptible to oxidation in the male germ line will be of value in focusing future analyses into the mutational load carried by children in response to paternal factors such as age, the treatment of male infertility using ART and paternal exposure to environmental toxicants. STUDY FUNDING/COMPETING INTEREST(S): Project support was provided by the University of Newcastle's (UoN) Priority Research Centre for Reproductive Science. M.J.X. was a recipient of a UoN International Postgraduate Research Scholarship. B.N. is the recipient of a National Health and Medical Research Council of Australia Senior Research Fellowship. Authors declare no conflict of interest.
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2018 |
Xavier MJ, Nixon B, Roman SD, Aitken RJ, 'Improved methods of DNA extraction from human spermatozoa that mitigate experimentally-induced oxidative DNA damage', PLOS ONE, 13 (2018) [C1]
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2017 |
Katen AL, Sipila P, Mitchell LA, Stanger SJ, Nixon B, Roman SD, 'Epididymal CYP2E1 plays a critical role in acrylamide-induced DNA damage in spermatozoa and paternally mediated embryonic resorptions', BIOLOGY OF REPRODUCTION, 96 921-935 (2017) [C1]
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2016 |
Stanger SJ, Law EA, Jamsai D, O'Bryan MK, Nixon B, McLaughlin EA, et al., 'A novel germ cell protein, SPIF (sperm PKA interacting factor), is essential for the formation of a PKA/TCP11 complex that undergoes conformational and phosphorylation changes upon capacitation', FASEB Journal, 30 2777-2791 (2016) [C1] © 2016 FASEB. Spermatozoa require the process of capacitation to enable them to fertilize an egg. PKA is crucial to capacitation and the development of hyperactivated motility. Sp... [more] © 2016 FASEB. Spermatozoa require the process of capacitation to enable them to fertilize an egg. PKA is crucial to capacitation and the development of hyperactivated motility. Sperm PKA is activated by cAMP generated by the germ cell-enriched adenylyl cyclase encoded by Adcy10. Male mice lacking Adcy10 are sterile, because their spermatozoa are immotile. The current studywas designed to identify binding partners of the sperm-specific (Ca2) catalytic subunit of PKA (PRKACA) by using it as the "bait" in a yeast 2-hybrid system. This approach was used to identify a novel germ cell-enriched protein, sperm PKA interacting factor (SPIF), in 25% of the positive clones. Homozygous Spif-nullmice were embryonically lethal. SPIF was coexpressed and coregulated with PRKACA and with t-complex protein (TCP)-11, a protein associated with PKA signaling. We established that these 3 proteins form part of a novel complex in mouse spermatozoa. Upon capacitation, the SPIF protein becomes tyrosine phosphorylatedin > 95% of sperm. Anapparent molecular rearrangement in the complex occurs, bringing PRKACA and TCP11 into proximity. Taken together, these results suggest a role for the novel complex of SPIF, PRKACA, and TCP11 during spermcapacitation, fertilization, and embryogenesis.
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2016 |
Katen AL, Chambers CG, Nixon B, Roman SD, 'Chronic Acrylamide Exposure in Male Mice Results in Elevated DNA Damage in the Germline and Heritable Induction of CYP2E1 in the Testes', BIOLOGY OF REPRODUCTION, 95 (2016) [C1]
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2016 |
Katen AL, Stanger SJ, Anderson AL, Nixon B, Roman SD, 'Chronic acrylamide exposure in male mice induces DNA damage to spermatozoa; Potential for amelioration by resveratrol', REPRODUCTIVE TOXICOLOGY, 63 1-12 (2016) [C1]
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2015 |
Katen AL, Roman SD, 'The genetic consequences of paternal acrylamide exposure and potential for amelioration', Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, 777 91-100 (2015) [C1] © 2015. Acrylamide is a toxin that humans are readily exposed to due to its formation in many carbohydrate rich foods cooked at high temperatures. Acrylamide is carcinogenic, neur... [more] © 2015. Acrylamide is a toxin that humans are readily exposed to due to its formation in many carbohydrate rich foods cooked at high temperatures. Acrylamide is carcinogenic, neurotoxic and causes reproductive toxicity when high levels of exposure are reached in mice and rats. Acrylamide induced effects on fertility occur predominantly in males. Acrylamide exerts its reproductive toxicity via its metabolite glycidamide, a product which is only formed via the cytochrome P450 detoxifying enzyme CYP2E1. Glycidamide is highly reactive and forms adducts with DNA. Chronic low dose acrylamide exposure in mice relevant to human exposure levels results in significantly increased levels of DNA damage in terms of glycidamide adducts in spermatocytes, the specific germ cell stage where Cyp2e1 is expressed. Since cells in the later stages of spermatogenesis are unable to undergo DNA repair, and this level of acrylamide exposure causes no reduction in fertility, there is potential for this damage to persist until sperm maturation and fertilisation. Cyp2e1 is also present within epididymal cells, allowing for transiting spermatozoa to be exposed to glycidamide. This could have consequences for future generations in terms of predisposition to diseases such as cancer, with growing indications that paternal DNA damage can be propagated across multiple generations. Since glycidamide is the major contributor to DNA damage, a mechanism for preventing these effects is inhibiting the function of Cyp2e1. Resveratrol is an example of an inhibitor of Cyp2e1 which has shown success in reducing damage caused by acrylamide treatment in mice.
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2015 |
Reid AT, Anderson AL, Roman SD, McLaughlin EA, McCluskey A, Robinson PJ, et al., 'Glycogen synthase kinase 3 regulates acrosomal exocytosis in mouse spermatozoa via dynamin phosphorylation', FASEB JOURNAL, 29 2872-2882 (2015) [C1]
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2014 |
Nixon BJ, Katen AL, Stanger SJ, Schjenken JE, Nixon B, Roman SD, 'Mouse spermatocytes express CYP2E1 and respond to acrylamide exposure', PLoS ONE, 9 (2014) [C1] Metabolism of xenobiotics by cytochrome P450s (encoded by the CYP genes) often leads to bio-activation, producing reactive metabolites that interfere with cellular processes and c... [more] Metabolism of xenobiotics by cytochrome P450s (encoded by the CYP genes) often leads to bio-activation, producing reactive metabolites that interfere with cellular processes and cause DNA damage. In the testes, DNA damage induced by xenobiotics has been associated with impaired spermatogenesis and adverse effects on reproductive health. We previously reported that chronic exposure to the reproductive toxicant, acrylamide, produced high levels of DNA damage in spermatocytes of Swiss mice. CYP2E1 metabolises acrylamide to glycidamide, which, unlike acrylamide, readily forms adducts with DNA. Thus, to investigate the mechanisms of acrylamide toxicity in mouse male germ cells, we examined the expression of the CYP, CYP2E1, which metabolises acrylamide. Using Q-PCR and immunohistochemistry, we establish that CYP2E1 is expressed in germ cells, in particular in spermatocytes. Additionally, CYP2E1 gene expression was upregulated in these cells following in vitro acrylamide exposure (1 µM, 18 h). Spermatocytes were isolated and treated with 1 µM acrylamide or 0.5 µM glycidamide for 18 hours and the presence of DNA-adducts was investigated using the comet assay, modified to detect DNA-adducts. Both compounds produced significant levels of DNA damage in spermatocytes, with a greater response observed following glycidamide exposure. A modified comet assay indicated that direct adduction of DNA by glycidamide was a major source of DNA damage. Oxidative stress played a small role in eliciting this damage, as a relatively modest effect was found in a comet assay modified to detect oxidative adducts following glycidamide exposure, and glutathione levels remained unchanged following treatment with either compound. Our results indicate that the male germ line has the capacity to respond to xenobiotic exposure by inducing detoxifying enzymes, and the DNA damage elicited by acrylamide in male germ cells is likely due to the formation of glycidamide adducts. © 2014 Nixon et al.
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2013 |
McIver SC, Roman SD, Nixon B, Loveland KL, McLaughlin EA, 'The rise of testicular germ cell tumours: The search for causes, risk factors and novel therapeutic targets', F1000 Research, 2 1-11 (2013) [C1]
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2013 |
Nixon BJ, Stanger SJ, Nixon B, Roman SD, 'Erratum to Chronic Exposure to Acrylamide Induces DNA Damage in Male Germ Cells of Mice [Toxicological Sciences, 129, 1 (2012) 135-145] doi:10.1093/toxsci/kfs178', Toxicological Sciences, 132 250 (2013)
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2013 |
McIver SC, Loveland KL, Roman SD, Nixon B, Kitazawa R, McLaughlin EA, 'The chemokine CXCL12 and its receptor CXCR4 are implicated in human seminoma metastasis', ANDROLOGY, 1 517-529 (2013) [C1]
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2012 |
Reid AT, Lord T, Stanger SJ, Roman SD, McCluskey A, Robinson PJ, et al., 'Dynamin regulates specific membrane fusion events necessary for acrosomal exocytosis in mouse spermatozoa', Journal of Biological Chemistry, 287 37659-37672 (2012) [C1]
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2012 |
Sutherland JM, Keightley RA, Nixon B, Roman SD, Robker RL, Russell DL, McLaughlin EA, 'Suppressor of cytokine signaling 4 (SOCS4): Moderator of ovarian primordial follicle activation', Journal of Cellular Physiology, 227 1188-1198 (2012) [C1]
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2012 |
Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Jumping the gun: Smoking constituent BaP causes premature primordial follicle activation and impairs oocyte fusibility through oxidative stress', Toxicology and Applied Pharmacology, 260 70-80 (2012) [C1]
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2012 |
Sobinoff AP, Nixon B, Roman SD, McLaughlin EA, 'Staying alive: PI3K pathway promotes primordial follicle activation and survival in response to 3MC-induced ovotoxicity', Toxicological Sciences, 128 258-271 (2012) [C1]
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2012 |
Nixon BJ, Stanger SJ, Nixon B, Roman SD, 'Chronic exposure to acrylamide induces DNA damage in male germ cells of mice', Toxicological Sciences, 129 135-145 (2012) [C1]
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2012 |
McIver SC, Roman SD, Nixon B, McLaughlin EA, 'miRNA and mammalian male germ cells', Human Reproduction Update, 18 44-59 (2012) [C1]
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2012 |
McIver SC, Stanger SJ, Santarelli DMF, Roman SD, Nixon B, McLaughlin EA, 'A unique combination of male germ cell mirnas coordinates gonocyte differentiation', PLoS One, 7 1-14 (2012) [C1]
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2011 |
Sobinoff AP, Mahony M, Nixon B, Roman SD, McLaughlin EA, 'Understanding the villain: DMBA-induced preantral ovotoxicity involves selective follicular destruction and primordial follicle activation through PI3K/Akt and mTOR signaling', Toxicological Sciences, 123 563-575 (2011) [C1]
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2010 |
Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Adding insult to injury: Effects of xenobiotic-induced preantral ovotoxicity on ovarian development and oocyte fusibility', Toxicological Sciences, 118 653-666 (2010) [C1]
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2006 |
Holt JE, Roman SD, Aitken RJ, McLaughlin EA, 'Identification and characterization of a novel Mt-retrotransposon highly represented in the female mouse germline', Genomics, 87 490-499 (2006) [C1]
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2006 |
Aitken RJ, Skakkebaek NE, Roman SD, 'Male reproductive health and the environment (Editorial)', Medical Journal of Australia, 185 414-415 (2006) [C3]
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2006 |
Holt JE, Jackson A, Roman SD, Aitken RJ, Koopman PA, McLaughlin EA, 'CXCR4/SDF1 interaction inhibits the primordial to primary follicle transition in the neonatal mouse ovary', Developmental Biology, 293 449-460 (2006) [C1]
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2006 |
Prabhu SM, Meistrich ML, McLaughlin EA, Roman SD, Warne S, Mendis S, et al., 'Expression of c-Kit receptor mRNA and protein in the developing, adult and irradiated rodent testis', Reproduction, 131 489-499 (2006) [C1]
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2005 |
Baleato R, Aitken RJ, Roman SD, 'Vitamin A regulation of BMP4 expression in the male germ line', Developmental Biology, 286 78-90 (2005) [C1]
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2005 |
Roman SD, Baleato RM, Aitken RJ, 'Interaction between BMP4 and retinoid signaling in mouse spermatogenesis', MECHANISMS OF DEVELOPMENT, 122 S126-S126 (2005)
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2004 |
Baker MA, Hetherington L, Ecroyd HW, Roman SD, Aitken RJ, 'Analysis of the mechanism by which calcium negatively regulates the tyrosine phoshorylation cascade associated with sperm capacitation', Journal of Cell Science, 117 211-222 (2004) [C1]
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2004 |
Curry BJ, Roman SD, Wallace C, Scott RJ, Miriami E, Aitken RJ, 'Identification and characterisation of a novel splice variant of mouse and rat cytochrome b5/cytochrome b5 reductase', Genomics, 83 425-438 (2004) [C1]
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2003 |
Sutton KA, Roman SD, 'Progesterone Responses in Human Spermatozoa', Chemtracts-Biochemistry and Molecular Biology, 183-187 (2003) [C2]
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2003 |
Wade MA, Roman SD, Jones RC, Aitken RJ, 'Adenylyl cyclase isoforms in rat testis and spermatozoa from the cauda epididymidis', Cell and Tissue Research, 314 411-419 (2003) [C1]
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2001 |
Sawyer DE, Roman SD, Aitken RJ, 'Relative susceptibilities of mitochondrial and nuclear DNA to damage induced by hydrogen peroxide in two mouse germ cell lines', Redox Report, 6 No. 3 182-184 (2001) [C1]
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1999 | Lane MA, Chen A, Roman S, Gudas L, 'Retinol metabolism is induced ln embryonic stem cells by the removal of leukemia inhibitory factor.', FASEB JOURNAL, 13 A866-A866 (1999) | ||||||||||
1999 |
Lane MA, Chen AC, Roman SD, Derguini F, Gudas LJ, 'Removal of LIF (leukemia inhibitory factor) results in increased vitamin A (retinol) metabolism to 4-oxoretinol in embryonic stem cells', Proceedings of the National Academy of Sciences of the United States of America, 96 13524-13529 (1999) Retinoids, vitamin A (retinol) and its metabolic derivatives, are required for normal vertebrate development. In murine embryonic stem (ES) cells, which remain undifferentiated wh... [more] Retinoids, vitamin A (retinol) and its metabolic derivatives, are required for normal vertebrate development. In murine embryonic stem (ES) cells, which remain undifferentiated when cultured in the presence of LIF (leukemia inhibitory factor), little metabolism of exogenously added retinol takes place. After LIF removal, ES cells metabolize exogenously added retinol to 4-hydroxyretinol and 4-oxoretinol and concomitantly differentiate. The conversion of retinol to 4-oxoretinol is a high-capacity reaction because most of the exogenous retinol is metabolized rapidly, even when cells are exposed to physiological (¿1 µM) concentrations of retinol in the medium. No retinoic acid or 4-oxoRA synthesis from retinol was detected in ES cells cultured with or without LIF. The cytochrome P450 enzyme CYP26 (retinoic acid hydroxylase) is responsible for the metabolism of retinol to 4-oxoretinol, and CYP26 mRNA is greatly induced (>15-fold) after LIF removal. Concomitant with the expression of CYP26, differentiating ES cells grown in the absence of LIF activate the expression of the differentiation marker gene FGF-5 whereas the expression of the stem cell marker gene FGF-4 decreases. The strong correlation between the production of polar metabolites of retinol and the differentiation of ES cells upon removal of LIF suggests that one important action of LIF in these cells is to prevent retinol metabolism to biologically active, polar metabolites such as 4-oxoretinol.
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Show 40 more journal articles |
Review (1 outputs)
Year | Citation | Altmetrics | Link | ||||
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2013 |
McIver SM, Roman SD, Nixon B, Loveland KL, McLaughlin EA, 'The rise of testicular germ cell tumours: the search for causes, risk factors and novel therapeutic targets', F1000Research (2013)
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Conference (44 outputs)
Year | Citation | Altmetrics | Link | ||||
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2012 |
Sobinoff AP, Beckett EL, Nixon B, Roman SD, Hansbro PM, McLaughlin EA, 'The impact of maternal cigarette smoke exposure on the male germline', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012, Gold Coast, QLD (2012) [E3]
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2012 |
Nixon BJ, Katen AL, Stanger SJ, Nixon B, Roman SD, 'Identifying biomarkers of chronic acrylamide exposure in the male germ line', Abstracts. The Annual Scientific Meeting of the Endocrine Society of Australia and the Society for Reproductive Biology 2012, Gold Coast, QLD (2012) [E3]
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2010 |
Fraser BA, Sobinoff AP, Pye VJ, Roman SD, Hime GR, Siddall NA, et al., 'Targets of RNA-binding protein Musashi-1 in mouse germ cell development', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Australia (2010) [E3]
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2010 |
McIver SC, Roman SD, Nixon B, McLaughlin EA, 'MicroRNA signalling in early male germ cells', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
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2010 |
Nixon BJ, Nixon B, Roman SD, 'The effect of acrylamide exposure on early male germ cells', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
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2010 |
Pye VJ, Sobinoff AP, Nixon B, Roman SD, McLaughlin EA, 'Xenobiotics; influence on long term oocyte viability', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
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2010 |
Reid AT, McEwan K, Campbell DM, Jans DA, Roman SD, 'Consistent nucleosome retention during chromatin packaging in human spermatozoa', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
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2010 |
Reid AT, Roman SD, Aitken RJ, Nixon B, 'Investigation of the role of dynamin in sperm surface remodelling', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
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2010 |
Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Consistent mechanism of primordial follicle activation in neonatal mouse ovotoxicity', OzBio 2010: The Molecules of Life - from Discovery to Biotechnology. Poster Abstracts, Melbourne, Vic (2010) [E3]
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2010 |
Roman SD, Reid AT, McEwan K, Campbell DM, Jans DA, 'Nucleosome Retention During Chromatin Packaging in Spermatozoa', Reproduction, Fertility and Development, Sydney (2010) [E3]
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2010 |
Sobinoff AP, Pye VJ, Nixon B, Roman SD, McLaughlin EA, 'Short Term Xenobiotic Exposure Compromises Long Term Oocyte Viability', Reproduction, Fertility and Development, Sydney (2010) [E3]
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2010 |
McIver SC, Roman SD, Nixon B, McLaughlin EA, 'Microrna and Early Male Germ Cells', Reproduction, Fertility and Development, Sydney (2010) [E3]
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2010 |
Nixon BJ, Nixon B, Roman SD, 'The Consequences of Acrylamide Exposure on the Male Germline', Reproduction, Fertility and Development, Sydney (2010) [E3]
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2010 |
Tannock SJ, McLaughlin EA, Aitken RJ, Roman SD, 'SPIF - A Novel Testis-Specific Gene and its Interaction with PKA', Reproduction, Fertility and Development, Sydney (2010) [E3]
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2010 |
Reid AT, Roman SD, Aitken RJ, Nixon B, 'Characterisation of the GTPASE dynamin throughout murine sperm maturation', Reproduction, Fertility and Development, Sydney, NSW (2010) [E3]
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2009 | Campbell DM, Roman SD, 'Chromatin packaging in human spermatozoa', Chromatin: Histones, Nucleosomes, Chromosomes & Genomes: Program & Abstract Book, Singapore (2009) [E3] | ||||||
2009 |
Roman SD, Stanger SJ, Borg Z, Low JL, McClymont SL, McLaughlin EA, 'Characterisation of spermatogonial stem cells', Regulatory Networks in Stem Cells: Program & Abstract Book, Singapore (2009) [E3]
|
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2008 |
Fraser BA, Sobinoff A, Hime G, Siddall N, Roman SD, McLaughlin EA, 'The role of the RNA-binding protein, Musashi-1 in murine spermatogonial stem cell maintenance', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction., Kailua-Kona, Hawaii (2008) [E3]
|
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2008 |
McLaughlin EA, Gunter KM, Woollett K, Roman SD, 'Chemokines: Role in germ cell migration and survival', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction. "Reproductive Biology: Basic Discoveries that Affect Our Lives", Kailua-Kona, Hawaii (2008) [E3]
|
||||||
2008 |
Aitken RJ, De Iuliis GN, Nixon B, Roman SD, 'Causes and clinical significance of DNA damage in the male germ line', Proceedings of 41st Annual Meeting of the Society for the Study of Reproduction. "Reproductive Biology: Basic Discoveries that Affect Our Lives", Kailua-Kona, Hawaii (2008) [E3]
|
||||||
2008 | Roman SD, Nixon BJ, Stanger SJ, Schjenken JE, 'Expression and activity of phase I detoxifying enzymes in the male germ line of the mouse', Biology of Reproduction, Kailua-Kona, Hawaii (2008) [E3] | ||||||
2007 |
Gunter KM, Fraser BA, Holt JE, Stanger SJ, Aitken RJ, Roman SD, McLaughlin EA, 'CXCR4/SDF1 interaction in the neonatal mouse testes', 7th Hunter Cellular Biology Meeting. Program, Hunter Valley, NSW (2007) [E3]
|
||||||
2007 |
Schjenken JE, Stanger SJ, Smith V, Douglas A, De Iuliis GN, Depaz I, et al., 'Expression and activity of phase 1 detoxifying enzymes in the male sperm line of the mouse', 7th Hunter Cellular Biology Meeting. Program, Hunter Valley, NSW (2007) [E3]
|
||||||
2007 | Campbell DM, Roman SD, 'Use of chromatin immunoprecipitation (CHIP) on the genomes of human spermatozoa', Combined Conference Abstracts - ComBio 2007 Conference, Sydney (2007) [E3] | ||||||
2007 | Roman SD, 'Expression and activity of phase 1 detoxifying enzymes in the male germ line of the mouse', Proceedings of the Thirty-Eighth Annual Conference Society for Reproductive Biology, Christchurch, New Zealand (2007) [E3] | ||||||
2007 |
Roman SD, Stanger SJ, Fraser BA, Borg Z, Low JL, McClymont SL, McLaughlin EA, 'Isolating and genotyping spermatogonial stem cells', Proceedings of the Thirty-Eighth Annual Conference Society for Reproductive Biology, Christchurch, New Zealand (2007) [E3]
|
||||||
2006 |
Fraser BA, Holt JE, Andrew J, Roman SD, Stanger SJ, Aitken RJ, et al., 'CXCR4/SDF1 Interactionin the Embryonic and Neonatal Mpise Testes', Abstracts, Brisbane Convention Centre, QLD, Australia (2006) [E3]
|
||||||
2006 |
McLaughlin EA, Dorey RA, Roman SD, Aitken RJ, 'Xenobiotis and Fertility: Expression Profiling of Defence Mechanisms Present in Murine Ovary', Abstract Book, Lorne, VIC, Australia (2006) [E3]
|
||||||
2006 |
Schjenken JE, Gilliam E, Borg Z, Aitken RJ, McLaughlin EA, Roman SD, 'Cytocrome P450 2E2 Mediates Acrylamide Damage to the Male Germ Line', Abstract Book, Lorne, VIC, Australia (2006) [E3]
|
||||||
2006 |
Holt JE, Andrew J, Roman SD, Stanger SJ, Aitken RJ, Peter K, McLaughlin EA, 'CXCR4/SDF-1 interaction in the embryonic and neonatal mouse tests', Book of Abstracts, Chicago, Illinois (2006) [E3]
|
||||||
2005 |
Holt JE, Aitken RJ, Roman SD, McLaughlin E, 'Use of RNA interference for the functional analysis of genes involved in ovarian development', MECHANISMS OF DEVELOPMENT (2005) [E3]
|
||||||
2005 |
Hime G, Marriner N, McLaughlin E, Roman S, Loveland K, Siddall N, 'The RNA-binding protein musashi is required for stem cell maintenance in the Drosophila testis', MECHANISMS OF DEVELOPMENT (2005) [E3]
|
||||||
2004 |
Holt JE, Aitken RJ, Roman SD, McLaughlin EA, 'Expression of the Chemokine CXCL12 and its receptor CXCR4 in the activating Mammalian Ovarian follicle', Reproduction, Fertility and Development, Sydney (2004) [E3]
|
||||||
2004 |
Baleato R, Aitken RJ, Roman SD, 'Interaction between bone morphogenetic protein 4 and retinoid signalling in mouse spermatogenesis', Reproduction, Fettility and Development, Darling Harbour, NSW, Australia (2004) [E3]
|
||||||
2004 |
Roman SD, McLaughlin EA, 'Peer pressure and performance: meaningful team work', Proceedings of Scholarly Inquiry into Science Teaching and Leaning, University of Sydney (2004) [E3]
|
||||||
2003 |
Holt JE, Aitken RJ, Roman SD, McLaughlin EA, 'Gene expression in the activating mammalian ovarian follicle', ComBio Combined Conference Abstracts, Melbourne (2003) [E3]
|
||||||
2003 |
Baker MA, Hetherington L, Ecroyd HW, Roman SD, Aitken RJ, 'Analysis of the mechanism by which calcium negatively regulates the tyrosine phosphorylation cascade associated with sperm capacitation', ComBio Combined Conference Abstracts, Melbourne (2003) [E3]
|
||||||
2003 |
Baleato R, Aitken RJ, Roman SD, 'Regulation of gene expression in mouse germ cells by retinoids', ComBio Combined Conference Abstracts, Melbourne (2003) [E3]
|
||||||
2003 |
Roman SD, Baleato R, Aitken RJ, 'Retinoid responsiveness of the murine spermatogonial cell line GC-1', Functional Genomics of Male Reproductions, Phoenix, Arizona (2003) [E3]
|
||||||
2003 |
Wade MA, Roman SD, Jones RC, Aitken RJ, 'Gene Expression of Adenylyl Cyclase in Rat Testis', The Third International Conference on the Epididymis, Charlottesville, Virginia (2003) [E3]
|
||||||
2002 |
Wade MA, Roman SD, Jones RC, Aitken RJ, 'Gene expression of adenylyl cyclase in rat testis and caudal epididymal sperm', Reproduction, Fertility and Development, Adelaide, SA (2002) [E3]
|
||||||
2002 |
Baleato R, Aitken RJ, Roman SD, 'Retinoid Responsiveness of Adult Murine Germ Cells', Proceedings of the Australian Society for Biochemistry and Molecular Biology, Sydney, NSW (2002) [E3]
|
||||||
2002 |
Sutton KA, Wallace C, Aitken RJ, Roman SD, 'Identifying markers of the mammalian male germ line using subtractive hybridisation', Proceedings of the Australian Society for Biochemistry and Molecular Biology, Sydney, NSW (2002) [E3]
|
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Show 41 more conferences |
Grants and Funding
Summary
Number of grants | 42 |
---|---|
Total funding | $23,638,668 |
Click on a grant title below to expand the full details for that specific grant.
20191 grants / $227,700
New Colombo Plan: Malaysia Interships Consortium$227,700
Funding body: New Colombo Plan Student Mobility Project, Australian Government
Funding body | New Colombo Plan Student Mobility Project, Australian Government |
---|---|
Project Team | UNSW (lead), UON (myself), UOW, The Global Student, |
Scheme | New Columbo Plan Mobility Grant |
Role | Investigator |
Funding Start | 2019 |
Funding Finish | 2022 |
GNo | |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | N |
20171 grants / $2,500
Effects of acrylamide on the male germline$2,500
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Doctor Shaun Roman, Professor Brett Nixon, Miss Caitlin Chambers |
Scheme | HMRI Student Association 'Future' Postgraduate Medical Research Scholarship |
Role | Lead |
Funding Start | 2017 |
Funding Finish | 2017 |
GNo | G1700585 |
Type Of Funding | C3120 - Aust Philanthropy |
Category | 3120 |
UON | Y |
20141 grants / $10,000
Ameliorating the DNA damaging effects of acrylamide on the male germline.$10,000
Funding body: University of Newcastle - Faculty of Science & IT
Funding body | University of Newcastle - Faculty of Science & IT |
---|---|
Project Team | Doctor Shaun Roman |
Scheme | Strategic Initiative Research Fund (SIRF) |
Role | Lead |
Funding Start | 2014 |
Funding Finish | 2014 |
GNo | G1401044 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20132 grants / $26,000
NucleoCounter SP100$14,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Laureate Professor John Aitken, Professor Brett Nixon, Doctor Shaun Roman, Associate Professor Mark Baker, Doctor Geoffry De Iuliis, Doctor Lisa Mitchell, Doctor Matthew Jobling, Doctor Zamira Gibb, Mr Nenad Naumovski |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2013 |
Funding Finish | 2013 |
GNo | G1201175 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
Ameliorating male germline toxicology.$12,000
Funding body: University of Newcastle - Faculty of Science & IT
Funding body | University of Newcastle - Faculty of Science & IT |
---|---|
Project Team | Doctor Shaun Roman |
Scheme | Strategic Small Grant |
Role | Lead |
Funding Start | 2013 |
Funding Finish | 2013 |
GNo | G1401070 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20123 grants / $37,000
BMG SPECTROstar Nano$15,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Laureate Professor John Aitken, Professor Eileen McLaughlin, Ms Belinda Nixon, Doctor Shaun Roman, Associate Professor Mark Baker, Doctor Geoffry De Iuliis, Doctor Lisa Mitchell, Doctor Matthew Jobling |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2012 |
Funding Finish | 2012 |
GNo | G1100971 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
Developing a model to assess the effects of chronic chemical exposure on the male germ line$12,000
Funding body: University of Newcastle - Faculty of Science & IT
Funding body | University of Newcastle - Faculty of Science & IT |
---|---|
Project Team | Doctor Shaun Roman |
Scheme | Strategic Small Grant |
Role | Lead |
Funding Start | 2012 |
Funding Finish | 2012 |
GNo | G1401104 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Ultrasonic Homogenizer System and -80 ºC Freezers for chemical and biological sample storage$10,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Adam McCluskey, Professor Eileen McLaughlin, Professor Peter Lewis, Ms Belinda Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Associate Professor Ian Grainge |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2012 |
Funding Finish | 2012 |
GNo | G1100986 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
20112 grants / $459,961
Chemical Biology$444,961
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Adam McCluskey, Doctor Warwick Belcher, Associate Professor Ian Grainge, Professor Christopher Grof, Professor Peter Lewis, Professor Eileen McLaughlin, Doctor Shaun Roman, Emeritus Professor Ray Rose, Doctor Jennette Sakoff, Associate Professor Nikki Verrills |
Scheme | Priority Research Centre |
Role | Investigator |
Funding Start | 2011 |
Funding Finish | 2013 |
GNo | G1100052 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Eileen McLaughlin, Professor Peter Lewis, Professor Adam McCluskey, Conjoint Professor Keith Jones, Professor Brett Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Associate Professor Ian Grainge, Doctor Janet Bristow, Doctor Xiao Yang |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2011 |
Funding Finish | 2011 |
GNo | G1100028 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
20107 grants / $2,111,472
Sex Ratio and Sterility for Commercial animal production - round 5 Cluster$700,000
Funding body: CSIRO - Commonwealth Scientific and Industrial Research Organisation
Funding body | CSIRO - Commonwealth Scientific and Industrial Research Organisation |
---|---|
Project Team | Laureate Professor John Aitken, Professor Eileen McLaughlin, Doctor Shaun Roman |
Scheme | National Research Flagship Cluster |
Role | Investigator |
Funding Start | 2010 |
Funding Finish | 2011 |
GNo | G1000045 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$500,000
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Professor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Phillip Robinson, Professor Eileen McLaughlin, Emeritus Professor Geoffrey Lawrance, Emeritus Professor Marcel Maeder, Professor Hugh Dunstan, Doctor Shaun Roman, Conjoint Professor Rob Atkin, Associate Professor Clovia Holdsworth, Associate Professor Mark Baker, Associate Professor Nikki Verrills, Professor Gottfried Otting, Professor Brett Nixon, Doctor Xiaojing Zhou, Ms Megan Chircop, Doctor Warwick Belcher |
Scheme | Linkage Infrastructure Equipment & Facilities (LIEF) |
Role | Investigator |
Funding Start | 2010 |
Funding Finish | 2010 |
GNo | G0190402 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
Laser microdissection microscopy system for cell and development biology$350,000
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Laureate Professor John Aitken, Professor Brett Nixon, Doctor Shaun Roman, Professor Alan Brichta, Doctor Rick Thorne, Associate Professor Doug Smith, Associate Professor David McCurdy, Emeritus Professor Ray Rose, Professor Christopher Grof, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Associate Professor Brett Graham, Associate Professor Paul Tooney, Laureate Professor Roger Smith, Laureate Professor Paul Foster, Professor Trevor Day, Conjoint Professor Robert Callister |
Scheme | Linkage Infrastructure Equipment & Facilities (LIEF) |
Role | Investigator |
Funding Start | 2010 |
Funding Finish | 2010 |
GNo | G0190369 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
An Integrated LC-MS-NMR facility for Applications in Proteomics and Organic Chemistry$280,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Adam McCluskey, Laureate Professor John Aitken, Professor Paul Dastoor, Professor Phillip Robinson, Professor Eileen McLaughlin, Emeritus Professor Geoffrey Lawrance, Emeritus Professor Marcel Maeder, Professor Hugh Dunstan, Doctor Shaun Roman, Conjoint Professor Rob Atkin, Associate Professor Clovia Holdsworth, Associate Professor Mark Baker, Associate Professor Nikki Verrills, Professor Gottfried Otting, Professor Brett Nixon, Doctor Xiaojing Zhou, Ms Megan Chircop, Doctor Warwick Belcher |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2010 |
Funding Finish | 2010 |
GNo | G1000873 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Laser microdissection microscopy system for cell and development biology$215,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Laureate Professor John Aitken, Professor Brett Nixon, Doctor Shaun Roman, Professor Alan Brichta, Doctor Rick Thorne, Associate Professor Doug Smith, Associate Professor David McCurdy, Emeritus Professor Ray Rose, Professor Christopher Grof, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Associate Professor Brett Graham, Associate Professor Paul Tooney, Laureate Professor Roger Smith, Laureate Professor Paul Foster, Professor Trevor Day, Conjoint Professor Robert Callister |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2010 |
Funding Finish | 2010 |
GNo | G1000874 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Laser microdissection microscopy system for cell and development biology (HMRI contribution towards 2010 ARC LIEF grant)$50,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Laureate Professor John Aitken, Professor Brett Nixon, Doctor Shaun Roman, Professor Alan Brichta, Doctor Rick Thorne, Associate Professor Doug Smith, Associate Professor David McCurdy, Emeritus Professor Ray Rose, Professor Christopher Grof, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Associate Professor Brett Graham, Associate Professor Paul Tooney, Laureate Professor Roger Smith, Laureate Professor Paul Foster, Professor Trevor Day, Conjoint Professor Robert Callister |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2010 |
Funding Finish | 2010 |
GNo | G1000144 |
Type Of Funding | Other Public Sector - State |
Category | 2OPS |
UON | Y |
Identifying vulnerable sites in the male genome$16,472
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Doctor Shaun Roman |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2010 |
Funding Finish | 2010 |
GNo | G0900133 |
Type Of Funding | Contract - Aust Non Government |
Category | 3AFC |
UON | Y |
20094 grants / $845,000
An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$495,000
Funding body: ARC (Australian Research Council)
Confocal Laser Scanning Microscopy for Live Cell Imaging$275,000
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Conjoint Professor Keith Jones, Professor Eileen McLaughlin, Laureate Professor John Aitken, Emeritus Professor Ray Rose, Emeritus Professor John Patrick, Conjoint Professor Christina Offler, Associate Professor David McCurdy, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Professor Dirk Van Helden, Associate Professor Nikki Verrills, Professor Brett Nixon, Doctor Shaun Roman, Professor Yong-Ling Ruan, Doctor Rick Thorne, Professor Mike Calford |
Scheme | Linkage Infrastructure Equipment & Facilities (LIEF) |
Role | Investigator |
Funding Start | 2009 |
Funding Finish | 2009 |
GNo | G0189038 |
Type Of Funding | Scheme excluded from IGS |
Category | EXCL |
UON | Y |
An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$50,000
Funding body: ARC (Australian Research Council)
LAS-4000 Chemiluminescence imaging system$25,000
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Eileen McLaughlin, Laureate Professor John Aitken, Professor Peter Lewis, Professor Brett Nixon, Doctor Shaun Roman |
Scheme | Equipment Grant |
Role | Investigator |
Funding Start | 2009 |
Funding Finish | 2009 |
GNo | G0189852 |
Type Of Funding | Other Public Sector - Commonwealth |
Category | 2OPC |
UON | Y |
20083 grants / $9,659,764
Centre for Biotechnology and Development$8,999,866
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Laureate Professor John Aitken, Dr Gary Hime, Professor M Holland, Professor D Jans, Professor P Koopman, Dr Kate Loveland, Professor Eileen McLaughlin, Dr M O'Bryan, Doctor Shaun Roman, Assoc. Prof A Sinclair |
Scheme | ARC Centres of Excellence |
Role | Investigator |
Funding Start | 2008 |
Funding Finish | 2010 |
GNo | G0188624 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Xenobiotics - ocidative stress in the mammalian ovary$362,625
Funding body: NHMRC (National Health & Medical Research Council)
Funding body | NHMRC (National Health & Medical Research Council) |
---|---|
Project Team | Professor Eileen McLaughlin, Professor Brett Nixon, Doctor Shaun Roman |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2008 |
Funding Finish | 2010 |
GNo | G0187620 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
Centre for Biotechnology and Development$297,273
Funding body: NSW Department of State and Regional Development
Funding body | NSW Department of State and Regional Development |
---|---|
Project Team | Laureate Professor John Aitken, Dr Gary Hime, Professor M Holland, Professor D Jans, Professor P Koopman, Dr Kate Loveland, Professor Eileen McLaughlin, Dr M O'Bryan, Doctor Shaun Roman, Assoc. Prof A Sinclair |
Scheme | ARC Centres of Excellence Partner Funding |
Role | Investigator |
Funding Start | 2008 |
Funding Finish | 2010 |
GNo | G0189183 |
Type Of Funding | Other Public Sector - State |
Category | 2OPS |
UON | Y |
20073 grants / $117,920
Centre for Biotechnology and Development.$96,220
Funding body: NSW Department of State and Regional Development
Funding body | NSW Department of State and Regional Development |
---|---|
Project Team | Laureate Professor John Aitken, Dr Kate Loveland, Professor P Koopman, Assoc. Prof A Sinclair, Professor D De Krester, Dr M O'Bryan, Dr Gary Hime, Professor D Jans, Doctor Shaun Roman, Professor Eileen McLaughlin, Professor C Goodnow, Professor M Holland |
Scheme | ARC Centres of Excellence Partner Funding |
Role | Investigator |
Funding Start | 2007 |
Funding Finish | 2007 |
GNo | G0187937 |
Type Of Funding | Other Public Sector - State |
Category | 2OPS |
UON | Y |
Chemokines and spermatogenesis: roles of SDF-1 and CXCR-4 in the establishment of spermatogenesis$20,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Professor Eileen McLaughlin, Doctor Shaun Roman, Professor Brett Nixon |
Scheme | Near Miss Grant |
Role | Investigator |
Funding Start | 2007 |
Funding Finish | 2007 |
GNo | G0187197 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Annual Scientific Meeting of the Society for Reproductive Biology, Christchurch NZ, 2/9/2007 - 5/9/2007$1,700
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Doctor Shaun Roman |
Scheme | Travel Grant |
Role | Lead |
Funding Start | 2007 |
Funding Finish | 2007 |
GNo | G0188087 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20063 grants / $571,555
PRC - Priority Research Centre for Reproductive Science$544,282
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Laureate Professor John Aitken, Laureate Professor Roger Smith, Professor Eileen McLaughlin, Professor Brett Nixon, Doctor Shaun Roman, Conjoint Associate Professor Vicki Clifton, Conjoint Professor Warwick Giles, Professor Jon Hirst, Conjoint Associate Professor Rick Nicholson, Professor Ian Symonds |
Scheme | Priority Research Centre |
Role | Investigator |
Funding Start | 2006 |
Funding Finish | 2013 |
GNo | G0186945 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Environmental impacts on female fertility and the menopause$17,273
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Professor Eileen McLaughlin, Laureate Professor John Aitken, Doctor Shaun Roman |
Scheme | Research Grant |
Role | Investigator |
Funding Start | 2006 |
Funding Finish | 2006 |
GNo | G0186620 |
Type Of Funding | Contract - Aust Non Government |
Category | 3AFC |
UON | Y |
Elucidating the mechanics of transgenerational toxicity in the ageing male$10,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Doctor Shaun Roman, Professor John Attia, Dr Elizabeth Gillam |
Scheme | Near Miss Grant |
Role | Lead |
Funding Start | 2006 |
Funding Finish | 2006 |
GNo | G0186080 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20051 grants / $15,000
Gene profiling of the detoxifying enzymes in the male germ line$15,000
Funding body: Hunter Medical Research Institute
Funding body | Hunter Medical Research Institute |
---|---|
Project Team | Doctor Shaun Roman, Laureate Professor John Aitken |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2005 |
Funding Finish | 2005 |
GNo | G0184897 |
Type Of Funding | Contract - Aust Non Government |
Category | 3AFC |
UON | Y |
20041 grants / $8,000
In vivo regulation of spermatogonial gene expression by Vitamin A$8,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Doctor Shaun Roman, Laureate Professor John Aitken |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2004 |
Funding Finish | 2004 |
GNo | G0183416 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20034 grants / $9,495,296
Centre for Biotechnology and Development.$9,458,900
Funding body: ARC (Australian Research Council)
Funding body | ARC (Australian Research Council) |
---|---|
Project Team | Laureate Professor John Aitken, Dr Kate Loveland, Professor P Koopman, Assoc. Prof A Sinclair, Professor D De Krester, Dr M O'Bryan, Dr Gary Hime, Professor D Jans, Doctor Shaun Roman, Professor Eileen McLaughlin, Professor C Goodnow, Professor M Holland |
Scheme | ARC Centres of Excellence |
Role | Investigator |
Funding Start | 2003 |
Funding Finish | 2007 |
GNo | G0182214 |
Type Of Funding | Aust Competitive - Commonwealth |
Category | 1CS |
UON | Y |
The origin and control of oxidative stress in the placenta$29,666
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Laureate Professor John Aitken, Laureate Professor Roger Smith, Doctor Shaun Roman |
Scheme | Multi-Year Project Grant Scholarship |
Role | Investigator |
Funding Start | 2003 |
Funding Finish | 2005 |
GNo | G0182393 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Profiling germ cell gene expression during spermatogonial differentiation$5,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Doctor Shaun Roman, Professor Eileen McLaughlin |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2003 |
Funding Finish | 2003 |
GNo | G0182402 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
American Society of Andrology annual Meeting and associated workshops, Phoenix, Arizona, USA 26 March - 2 April, 2003$1,730
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Doctor Shaun Roman |
Scheme | Travel Grant |
Role | Lead |
Funding Start | 2003 |
Funding Finish | 2003 |
GNo | G0182915 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20022 grants / $13,000
Regulation of gene expression during spermatogonial development$8,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Doctor Shaun Roman |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2002 |
Funding Finish | 2002 |
GNo | G0181441 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Characterisation of a non-genomic progesterone receptor in round spermatids$5,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Doctor Shaun Roman, Laureate Professor John Aitken |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2002 |
Funding Finish | 2002 |
GNo | G0181445 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20011 grants / $8,500
Interaction of Smad and Retinoid signalling pathways.$8,500
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Doctor Shaun Roman |
Scheme | Project Grant |
Role | Lead |
Funding Start | 2001 |
Funding Finish | 2001 |
GNo | G0180093 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
20001 grants / $10,000
Molecular basis of spermatogenesis$10,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Dr Keith Sutton, Laureate Professor John Aitken, Doctor Shaun Roman |
Scheme | Project Grant |
Role | Investigator |
Funding Start | 2000 |
Funding Finish | 2000 |
GNo | G0178860 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
19992 grants / $20,000
Culture and genetic manipulation of male germ-line stem cells$11,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Doctor Shaun Roman |
Scheme | New Staff Grant |
Role | Lead |
Funding Start | 1999 |
Funding Finish | 1999 |
GNo | G0178424 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Isolation of genetic markers to follow male germ cell progression from birth to spermatocyte.$9,000
Funding body: University of Newcastle
Funding body | University of Newcastle |
---|---|
Project Team | Doctor Shaun Roman |
Scheme | Early Career Researcher Grant |
Role | Lead |
Funding Start | 1999 |
Funding Finish | 1999 |
GNo | G0179147 |
Type Of Funding | Internal |
Category | INTE |
UON | Y |
Research Supervision
Number of supervisions
Current Supervision
Commenced | Level of Study | Research Title | Program | Supervisor Type |
---|---|---|---|---|
2019 | PhD | The Role of Autophagy in Oocyte Development and Ageing | PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle | Co-Supervisor |
2018 | Honours | The Effect of DNA Damage in Sperm on Fertilization and Embryo Development | Biological Sciences, School of Environmental and Life Sciences, Faculty of Science, The university of Newcastle, Australia | Principal Supervisor |
2018 | Honours | Exploring protein aggregation in the male germ line in response to toxicant induced stress. | Biological Sciences, School of Environmental & Life Sciences - Faculty of Science & IT - The University of Newcastle | Australia | Co-Supervisor |
2017 | PhD | Primordial Follicle Activation in Premature Ovarian Failure: Understanding and Managing Fertility | PhD (Medical Biochemistry), Faculty of Health and Medicine, The University of Newcastle | Co-Supervisor |
2017 | PhD | Epididymosomes and Environmental Epigenetic Inheritance | PhD (Biological Sciences), Faculty of Science, The University of Newcastle | Co-Supervisor |
2016 | PhD | The Impact of the Environmental Hazard, Acrylamide, on the Male Reproductive Tract and Transgenerational Phenotype | PhD (Biological Sciences), Faculty of Science, The University of Newcastle | Principal Supervisor |
2007 | PhD | The role of SDF-1/CXCR4 in spermatogenesis | Biological Sciences, University of Newcastle | Co-Supervisor |
Past Supervision
Year | Level of Study | Research Title | Program | Supervisor Type |
---|---|---|---|---|
2018 | PhD | Post-Meiotic DNA Damage in Spermatozoa and Consequences to Offspring | PhD (Biological Sciences), Faculty of Science, The University of Newcastle | Co-Supervisor |
2017 | PhD | The Consequences of Paternal Acrylamide Exposure and Potential for Amelioration | PhD (Biological Sciences), Faculty of Science, The University of Newcastle | Principal Supervisor |
2015 | PhD | The Influence of Peroxisomes on Reactive Oxygen Species Regulation and Regeneration Induction in Plants | PhD (Biological Sciences), Faculty of Science, The University of Newcastle | Co-Supervisor |
2015 | PhD | Functional Characterisation of Dynamin in Mouse Spermatozoa | PhD (Biological Sciences), Faculty of Science, The University of Newcastle | Co-Supervisor |
2015 | Honours | DNA damage and expression of Cyp2e1 in the male reproductive tract | Biological Sciences, The University of Newcastle | Sole Supervisor |
2014 | PhD | The Consequences of Acrylamide Exposure of the Male Germ Line | PhD (Biological Sciences), Faculty of Science, The University of Newcastle | Principal Supervisor |
2013 | PhD | Regulation of the Transition from Gonocytes to Spermatogonia | PhD (Biological Sciences), Faculty of Science, The University of Newcastle | Co-Supervisor |
2013 | PhD | Investigation of the Transcription Complex in Acinetobacter baylyi ADP1 and the Identification of the Novel Small Acidic Transcription Factor AtfA | PhD (Biological Sciences), Faculty of Science, The University of Newcastle | Co-Supervisor |
2012 | Honours | Amelioration of acrylamide toxicity in the male germ line | Biological Sciences, The University of Newcastle, Australia | Sole Supervisor |
2012 | PhD | Xenobiotics; Effects on Female Fertility | PhD (Biological Sciences), Faculty of Science, The University of Newcastle | Co-Supervisor |
2011 | Honours | An assessment of DNA packaging in human sperm | Biological Sciences, The University of Newcastle, NSW | Sole Supervisor |
2009 | PhD | The Nature of Chromatin Packaging in Human Spermatozoa | PhD (Biological Sciences), Faculty of Science, The University of Newcastle | Principal Supervisor |
2009 | Honours | Chromatin packaging in human spermatozoa | Biological Sciences, Univeristy of Newcastle | Sole Supervisor |
2008 | Honours | Acrylamide toxicity in the male germ line | Biological Sciences, The University of Newcastle | Sole Supervisor |
2008 | Honours | BMP4 signalling in spermatogenesis | Biological Sciences, The University of Newcastle | Sole Supervisor |
2008 | Honours | The role of retinoids in the male germ line | Biological Sciences, The University of Newcastle, NSW | Sole Supervisor |
2007 | Honours | SDF-1/CXCR4 signalling in the testis | Biological Sciences, Univeristy of Newcastle | Principal Supervisor |
2006 | PhD | Gene Expression During Development of the Mammalian Ovarian Primordial Follicle | PhD (Biological Sciences), Faculty of Science, The University of Newcastle | Co-Supervisor |
2005 | Honours | Cytochrome P450 gene expression in the male germ line | Biological Sciences, University of Newcastle | Sole Supervisor |
2005 | PhD | The Regulation of Gene Expression by Vitamin A during Mouse Spermatogenesis | PhD (Biological Sciences), Faculty of Science, The University of Newcastle | Sole Supervisor |
2004 | Honours | SOCS expression in the ovary | Biological Sciences, University of Newcastle | Co-Supervisor |
2003 | PhD | Sperm Motility | Biol Sc Not Elsewhere Classifd, University of Newcastle | Co-Supervisor |
2003 | Honours | Characterisation of the sperm progesterone receptor | Biological Sciences, University of Newcastle | Co-Supervisor |
2003 | Honours | DNA damage and chromatin packaging in human spermatozoa | Biological Sciences, University of Newcastle | Co-Supervisor |
2001 | Honours | TGF-b signalling | Biological Sciences, University of Newcastle | Principal Supervisor |
2000 | Honours | Foetal Organ Culture | Biological Sciences, University of Newcastle | Co-Supervisor |
2000 | Honours | Factors Regulating Spermatogenesis | Biological Sciences, University of Newcastle | Co-Supervisor |
2000 | Honours | Oxidases in Aradopsis | Biological Sciences, University of Newcastle | Co-Supervisor |
1999 | Honours | Oxidases in Wallaby Spermatozoa | Biological Sciences, University of Newcastle | Co-Supervisor |
1999 | Honours | Mammalian Sex Determination | Biological Sciences, University of Newcastle | Co-Supervisor |
News
Sperm decline an early warning sign rather than a crisis alert
July 26, 2017
Dr Shaun Roman
Position
Senior Lecturer
School of Environmental and Life Sciences
Faculty of Science
Focus area
Biological Sciences
Contact Details
shaun.roman@newcastle.edu.au | |
Phone | (02) 4921 6818 |
Fax | (02) 4921 6923 |
Office
Room | LS4-37 |
---|---|
Building | Life Sciences. |
Location | Callaghan University Drive Callaghan, NSW 2308 Australia |