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Biography

Meiosis is the name given to the two cell divisions germ cells go through following DNA replication in order to produce haploid gametes. Our research focuses on mammalian female meiosis where we use imaging based techniques (Fluorescent Protein chimeras) to explore this process in real-time. We argue that this is an important strategy when examining a dynamic process such as the meiotic cell cycle.

Meiosis is important to study because of its unique cell division; in terms of understanding a fundamental cellular developmental biology process; and also because errors in meiotic division lead to aneuploid embryos, the leading cause of early pregnancy loss in humans and the cause of Down's Syndrome.

Research Highlights: The mammalian oocyte spends most of its life arrested at prophase of the first meiotic division and we found that APCcdh1 activity was necessary in order to achieve this arrest (Reis et al., Nature Cell Biology, 2006). Recently we extended these observations to show that APCcdh1 also functioned in prometaphase to prevent aneuploidy in maturing oocytes (Reis et al., Nature Cell Biology, 2007). In the first meiotic division chromosome homologues are separated, a unique cell division, and in 2006 we found that during this division separase is needed to inhibit MPF activity (Gorr et al., Nature Cell Biology, 2006. See Nature Cell Biology, News & Views). Following exit from the first meiotic division the egg re-arrests at metaphase of the second meiotic division until sperm break this arrest with a cytosolic calcium signal. Re-arrest at metaphase of the second meiotic division requires the APC inhibitor Emi2 (Madgwick et al., Journal of Cell Biology, 2006). At fertilization the sister chromatids are separated. Another unequal cell division occurs, and the second polar body is extruded. The fertilized oocyte completes meiosis and forms a zygote.

We are very much interested in how the two meiotic divisions are controlled at a molecular level. Our approach is to over-express and visualise gene products by tagging them with a toolkit of Fluorescent Proteins (Cyan; Cerulean; Yellow, Green; Venus; and Red Fluorescent Proteins) and knock them out using antisense morpholinos.

Qualifications

  • Doctor of Philosophy, University of Liverpool - UK, 11/07/1994
  • Bachelor of Science (Biochemistry)(Honours), University of Leeds - UK, 07/07/1989

Research

Research keywords

  • Cell Cycle
  • Cell Division
  • Chromosomes
  • Female Fertility
  • Meiosis
  • Mitosis
  • Oocytes
  • Ovarian Biology
  • Reproductive Biology

Research expertise

Mammalian reproductive biology, especially female reproduction with emphasis on oocytes and the meiotic divisions. Cell division and early embryo development, such as the transition from meiosis to mitosis, and the embryonic divisions leading up to implantation. Mitotic cell divisions of cultured cells, and the control of M-phase. Mis-segregation of chromosomes that lead to aneuploidy. Control of the meiotic divisions of oocytes with focus on the mechanisms that control faithful chromosome segregation such as the Spindle Assembly Checkpoint.

Fields of Research

CodeDescriptionPercentage
060699Physiology Not Elsewhere Classified45
060100Biochemistry And Cell Biology35
111499Paediatrics And Reproductive Medicine Not Elsewhere Classified20
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.

Click on a category title below to expand the list of citations for that specific category.

Chapter (3 outputs)

YearCitationAltmetricsLink
2013Holt JE, Lane SIR, Jones KT, 'The Control of Meiotic Maturation in Mammalian Oocytes', Gametogenesis, Academic Press, San diego 207-226 (2013) [B1]
2013Jones KT, Lane SIR, Holt JE, 'Start and Stop Signals of Oocyte Meiotic Maturation', Oogenesis, Springer, London 183-193 (2013) [B1]
2011Jones KT, 'Anaphase-promoting complex control in female mouse meiosis', Cell Cycle in Development, Springer, Berlin 343-363 (2011) [B1]

Journal article (50 outputs)

YearCitationAltmetricsLink
2014Lane SI, Jones KT, 'Non-canonical function of spindle assembly checkpoint proteins after APC activation reduces aneuploidy in mouse oocytes.', Nat Commun, 5 3444 (2014)
2014Holt JE, Pye V, Boon E, Stewart JL, García-Higuera I, Moreno S, et al., 'The APC/C activator FZR1 is essential for meiotic prophase I in mice.', Development, 141 1354-1365 (2014)
2014Yun Y, Lane SIR, Jones KT, 'Premature dyad separation in meiosis II is the major segregation error with maternal age in mouse oocytes', DEVELOPMENT, 141 199-208 (2014)
2013Lord T, Nixon B, Jones KT, Aitken RJ, 'Melatonin Prevents Postovulatory Oocyte Aging in the Mouse and Extends the Window for Optimal Fertilization In Vitro', Biology of Reproduction, 88 1-9 (2013) [C1]
2013Jamsai D, O'Connor AE, DeBoer KD, Clark BJ, Smith SJ, Browne CM, et al., 'Loss of GGN Leads to Pre-Implantation Embryonic Lethality and Compromised Male Meiotic DNA Double Strand Break Repair in the Mouse', PLOS ONE, 8 (2013) [C1]
2013Merriman JA, Lane SIR, Holt JE, Jennings PC, Garcia-Higuera I, Moreno S, et al., ' Reduced Chromosome Cohesion Measured by Interkinetochore Distance Is Associated with Aneuploidy Even in Oocytes from Young Mice', Biology of Reproduction, 88 31-31 (2013) [C1]
2013Holt JE, Lane SIR, Jones KT, 'Time-lapse epifluorescence imaging of expressed cRNA to cyclin B1 for studying meiosis i in mouse oocytes', Methods in Molecular Biology, 957 91-106 (2013) [C2]
2012Lane SI, Yun Y, Jones KT, 'Timing of anaphase-promoting complex activation in mouse oocytes is predicted by microtubule-kinetochore attachment but not by bivalent alignment or tension', Development (Cambridge), 139 1947-1955 (2012) [C1]
2012Merriman-Jones JA, Jennings PC, McLaughlin EA, Jones KT, 'Effect of aging on superovulation efficiency, aneuploidy rates, and sister chromatid cohesion in mice aged up to 15 months', Biology of Reproduction, 86 1-6 (2012) [C1]

Co-authors: Eileen McLaughlin

2012Yuen WS, Merriman-Jones JA, O'Bryan MK, Jones KT, 'DNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes', PLOS One, 7 e43875 (2012) [C1]
2012Jones KT, Lane SI, 'Chromosomal, metabolic, environmental, and hormonal origins of aneuploidy in mammalian oocytes', Experimental Cell Research, 318 1394-1399 (2012) [C1]
2012Holt JE, Lane SI, Jennings PC, Garcia-Higuera I, Moreno S, Jones KT, 'APC FZR1 prevents nondisjunction in mouse oocytes by controlling meiotic spindle assembly timing', Molecular Biology of the Cell, 23 3970-3981 (2012) [C1]

Co-authors: Janet Holt

2012Seah KYM, Holt JE, Garcia-Higuera I, Moreno S, Jones KT, 'The APC activator fizzy-related-1 (FZR1) is needed for preimplantation mouse embryo development', Journal of Cell Science, 125 6030-6037 (2012) [C1]

Co-authors: Janet Holt

2012Jones KT, Robertson SA, Aitken RJ, 'Reactive oxygen species and sperm function-in sickness and in health', Journal of Andrology, 33 1096-1106 (2012) [C1]

Co-authors: John Aitken

2012Liu W, Yin J, Zhao G, Yun Y, Wu S, Jones KT, Lei A, 'Differential regulation of cyclin B1 degradation between the first and second meiotic divisions of bovine oocytes', Theriogenology, 78 1171.e1-1181.e1 (2012) [C1]
2012Jones KT, 'Meiosis: Mouse eggs do their anaphase topsy-turvy', Current Biology, 22 R153-R155 (2012) [C3]
2011Holt JE, Tran SM-T, Stewart JL, Minahan KL, Garcia-Higuera I, Moreno S, Jones KT, 'The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes', Development, 138 905-913 (2011) [C1]
2011Jamsai D, Sarraj MA, Merriner DJ, Drummond AE, Jones KT, McLachlan RI, O'Bryan MK, 'GGN1 in the testis and ovary and its variance within the Australian fertile and infertile male population', International Journal of Andrology, 34 624-632 (2011) [C1]
2011Jennings PC, Merriman-Jones JA, Beckett EL, Hansbro PM, Jones KT, 'Increased zona pellucida thickness and meiotic spindle disruption in oocytes from cigarette smoking mice', Human Reproduction, 26 878-884 (2011) [C1]
2011Chang H-Y, Jennings PC, Stewart JL, Verrills NM, Jones KT, 'Essential role of protein phosphatase 2A in metaphase II arrest and activation of mouse eggs shown by okadaic acid, dominant negative protein phosphatase 2A, and FTY720', Journal of Biological Chemistry, 286 14705-14712 (2011) [C1]
2011Lane SI, Jones KT, 'Phosphorylation of histone H3 in 1- and 2-cell embryos', Cell Cycle, 10 17-18 (2011) [C3]
2010Holt JE, Stewart JL, Jones KT, 'Spatial regulation of APC(Cdh1)-induced cyclin B1 degradation maintains G2 arrest in mouse oocytes', Development, 137 1297-1304 (2010) [C1]
2010Lane SI, Chang H-Y, Jennings PC, Jones KT, 'The Aurora kinase inhibitor ZM447439 accelerates first meiosis in mouse oocytes by overriding the spindle assembly checkpoint', Reproduction, 140 521-530 (2010) [C1]
2010Jones KT, Holt JE, 'BubR1 highlights essential function of Cdh1 in mammalian oocytes', Cell Cycle, 9 1029-1030 (2010) [C3]

Co-authors: Janet Holt

2010Jones KT, 'Cohesin and Cdk1: An anaphase barricade', Nature Cell Biology, 12 106-108 (2010) [C3]
2009Holt JE, Jones KT, 'Control of homologous chromosome division in the mammalian oocyte', Molecular Human Reproduction, 15 139-147 (2009) [C1]
2009Chang H-Y, Minahan KL, Merriman-Jones JA, Jones KT, 'Calmodulin-dependent protein kinase gamma 3 (CamKII[gamma]3) mediates the cell cycle resumption of metaphase II eggs in mouse', Development, 136 4077-4081 (2009) [C1]
2008Jones KT, 'Meiosis in oocytes: predisposition to aneuploidy and its increased incidence with age', Human Reproduction Update, 14 143-158 (2008) [C1]
2008Nabti I, Reis A, Levasseur M, Stemmann O, Jones KT, 'Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in mouse eggs', Developmental Biology, 321 379-386 (2008) [C1]
2007Jones KT, Swann K, 'Composition of sea urchin egg homogenate determines its potency to inositol trisphosphate and cyclic ADPRibose-induced Ca2+ release', Biochemical and Biophysical Research Communications, 360 815-820 (2007) [C1]
2007Levasseur M, Carroll M, Jones KT, McDougall A, 'A novel mechanism controls the Ca2+ oscillations triggered by activation of ascidian eggs and has an absolute requirement for Cdk1 activity', Journal of Cell Science, 120 1763-1771 (2007) [C1]
2007Jones KT, 'Intracellular calcium in the fertilization and development of mammalian eggs', Journal of Cellular Physiology, 34 1084-1089 (2007) [C1]
2007Madgwick S, Jones KT, 'How eggs arrest at metaphase II: MPF stabilisation plus APC/C inhibition equals Cytostatic Factor', Cell Division, 2 1-7 (2007) [C1]
2007Gardner AJ, Knott JG, Jones KT, Evans JP, 'CaMKII can participate in but is not sufficient for the establishment of the membrane block to polyspermy in mouse eggs', Journal of Cellular Physiology, 212 275-280 (2007) [C1]
2007Reis A, Madgwick S, Chang H-Y, Nabti I, Levasseur M, Jones KT, 'Prometaphase APCcdh1 activity prevents non-disjunction in mammalian oocytes', Nature Cell Biology, 9 1192-1198 (2007) [C1]
2006Knott JG, Gardner AJ, Madgwick S, Jones KT, Williams CJ, Schultz RM, 'Calmodulin-dependent protein kinase II triggers mouse egg activation and embryo development in the absence of Ca2+ oscillations', Developmental Biology, 296 388-395 (2006) [C1]
2006Reis A, Chang H-Y, Levasseur M, Jones KT, 'APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division', Nature Cell Biology, 8 539-540 (2006) [C1]
2006Gorr IH, Reis A, Boos D, Wühr M, Madgwick S, Jones KT, Stemmann O, 'Essential CDK1-inhibitory role for separase during meiosis I in vertebrate oocytes', Nature Cell Biology, 8 1035-1037 (2006) [C1]
2006Madgwick S, Hansen DV, Levasseur M, Jackson PK, Jones KT, 'Mouse Emi2 Is Required to Enter Meiosis II by Reestablishing Cyclin B1 During Interkinesis', The Journal of Cell Biology, 174 791-801 (2006) [C1]
2006Reis A, Levasseur M, Chang H-Y, Elliot DJ, Jones KT, 'The CRY box: A second APCcdh1-dependent degron in mammalian cdc20', EMBO Reports, 7 1040-1045 (2006) [C1]
2005Madgwick S, Levasseur M, Jones KT, 'Calmodulin-dependent protein kinase II, and not protein kinase C, is sufficient for triggering cell-cycle resumption in mammalian eggs', Journal of Cell Science, 118 3849-3859 (2005) [C1]
2005Coward K, Ponting CP, Chang H-Y, Hibbitt O, Savolainen P, Jones KT, Parrington J, 'Phospholipase C{zeta}, the trigger of egg activation in mammals, is present in a non-mammalian species', Reproduction, 130 157-163 (2005) [C1]
2005Jones KT, 'Mammalian egg activation: from Ca2+ spiking to cell cycle progression', Reproduction, 130 813-823 (2005) [C1]
2004Venables JP, Dalgliesh C, Paronetto MP, Skitt L, Thornton JK, Saunders PT, et al., 'SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome', Human Molecular Genetics, 13 1525-1534 (2004) [C1]
2004Madgwick S, Nixon VL, Chang H-Y, Herbert M, Levasseur M, Jones KT, 'Maintenance of sister chromatid attachment in mouse eggs through maturation-promoting factor activity', Developmental Biology, 275 68-81 (2004) [C1]
2004Hyslop LA, Nixon VL, Levasseur M, Chapman F, Chiba K, McDougall A, et al., 'Ca2+-promoted cyclin B1 degradation in mouse oocytes requires the establishment of a metaphase arrest', Developmental Biology, 269 206-219 (2004) [C1]
2004Jones KT, 'Turning it on and off: M-phase promoting factor during meiotic maturation and fertilization', Molecular Human Reproduction, 10 1-5 (2004) [C1]
2004Chang H-Y, Levasseur M, Jones KT, 'Degradation of APCcdc20 and APCcdh1 substrates during the second meiotic division in mouse eggs', Journal of Cell Science, 117 6289-6296 (2004) [C1]
2003Soeller C, Jacobs MD, Donaldson PJ, Cannell MB, Jones KT, Ellis-Davies GCR, 'Application of two-photon flash photolysis to reveal intercellular communication and intracellular Ca2+ movements.', Journal of Biomedical Optics, 8 418-427 (2003) [C1]
2003Carroll M, Levasseur M, Whitaker M, Jones KT, McDougall A, 'Exploring the mechanism of action of the sperm-triggered calcium-wave pacemaker in ascidian zygotes', Journal of Cell Science, 116 4997-5004 (2003) [C1]
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Conference (5 outputs)

YearCitationAltmetricsLink
2010Hopkins LA, Pye VJ, Fraser BA, Holt JE, Jones KT, McLaughlin EA, 'The Role of Fizzy Related 1 in Male Meiosis', Reproduction, Fertility and Development, Sydney (2010) [E3]
2010Chang H-Y, Jennings PC, Jones KT, 'The use of okadaic acid and FTY720 to examine the role of PP2A in the metaphase II arrest of mouse eggs', The American Society for Cell Biology 50th Annual Meeting Abstracts, Phildelphia, PA (2010) [E3]
2010Jones KT, 'CDH1: A cell cycle protein involved in female meiosis and prevention of aneuploidy', Reproduction, Fertility and Development, Sydney (2010) [E3]
2010Jennings PC, Jones KT, 'Investigating the Role of Cyclin A2 During Oocyte Meiosis', Reproduction, Fertility and Development, Sydney (2010) [E3]
2009Jones KT, Weaver J, Holt JE, 'The mechanism by which fizzy-related (Fzr1) controls pro-phase 1 arrest in mouse oocytes', Biology of Reproduction, Pittsburgh, PA (2009) [E3]

Co-authors: Janet Holt

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Grants and Funding

Summary

Number of grants28
Total funding$5,058,322

- Indicates that the researcher may be seeking students for this project.

Click on a grant title below to expand the full details for that specific grant.

2012 (3 grants)

Pregnancy and Reproduction MRSP 2011-12 $369,134
Funding Body: Hunter Medical Research Institute

Project Team
Professor Roger Smith, Laureate Professor John Aitken, Conjoint Professor Keith Jones
SchemeRole
NSW MRSP Infrastructure GrantInvestigator
Total AmountFunding StartFunding Finish
$369,13420122012
GNo:G1101192

Project EVA: an environmentally responsible facility for interdisciplinary supercomputing applications$263,000
Funding Body: University of Newcastle

Regulation of the cell cycle by phosphorylation dependent targeting of CaMKII$20,000
Funding Body: University of Newcastle

Project Team
Doctor Nikki Verrills, Doctor Kathryn Skelding, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Conjoint Professor Keith Jones
SchemeRole
Near Miss GrantInvestigator
Total AmountFunding StartFunding Finish
$20,00020122012
GNo:G1200679

2011 (7 grants)

Gamete-specific knockout of Fizzy-Related to examine its meiotic role in oocytes and sperm$600,000
Funding Body: ARC (Australian Research Council)

Project Team
Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Professor Sergio Moreno
SchemeRole
Discovery ProjectsInvestigator
Total AmountFunding StartFunding Finish
$600,00020112014
GNo:G1000020

An Advanced Mass Spectrometer for Applications in Phospho-Proteomics, Glycomics and Top-Down Sequencing of Proteins$250,000
Funding Body: ARC (Australian Research Council)

Project Team
Doctor Mark Baker, Laureate Professor John Aitken, Professor Roger Smith, Conjoint Professor Keith Jones, Conjoint Professor Ray Rose, Professor Lois Salamonsen
SchemeRole
Linkage Infrastructure Equipment & Facilities (LIEF)Investigator
Total AmountFunding StartFunding Finish
$250,00020112011
GNo:G1000632

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Phil Hansbro, Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$45,00020112011
GNo:G1100037

Factors affecting the quality of mammalian eggs when females age.$25,000
Funding Body: University of Newcastle

Project Team
Conjoint Professor Keith Jones
SchemeRole
Near Miss GrantChief Investigator
Total AmountFunding StartFunding Finish
$25,00020112011
GNo:G1001042

An Advanced Mass Spectrometer for Applications in Phospho-Proteomics, Glycomics and Top-Down Sequencing of Proteins$15,000
Funding Body: Prince Henry's Institute of Medical Research

Project Team
Doctor Mark Baker, Laureate Professor John Aitken, Professor Roger Smith, Conjoint Professor Keith Jones, Conjoint Professor Ray Rose, Professor Lois Salamonsen
SchemeRole
Linkage Infrastructure Equipment & Facilities (LIEF) Partner fundingInvestigator
Total AmountFunding StartFunding Finish
$15,00020112011
GNo:G1100844

Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Eileen McLaughlin, Professor Peter Lewis, Professor Adam McCluskey, Conjoint Professor Keith Jones, Associate Professor Brett Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge, Doctor Janet Holt, Doctor Xiao Yang
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$15,00020112011
GNo:G1100028

IMPLEN NanoPhotometer pearl$10,000
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Associate Professor Alan Brichta, Emeritus Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Professor Ulli Schall, Associate Professor Phillip Dickson, Doctor Frederick Walker, Doctor Rick Thorne, Doctor Chris Dayas, Doctor Nikki Verrills, Doctor Janet Holt, Doctor Severine Roselli, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Associate Professor Liz Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Mr Dan Johnstone, Ms Belinda Goldie, Ms Natalie Beveridge
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$10,00020112011
GNo:G1100030

2010 (5 grants)

HMRI MRSP Infrastructure Grant (10-11) - PREGNANCY & REPRODUCTION$362,277
Funding Body: Hunter Medical Research Institute

Project Team
Professor Roger Smith, Laureate Professor John Aitken, Conjoint Professor Keith Jones
SchemeRole
NSW MRSP Infrastructure GrantInvestigator
Total AmountFunding StartFunding Finish
$362,27720102010
GNo:G1100474

Laser microdissection microscopy system for cell and development biology$350,000
Funding Body: ARC (Australian Research Council)

Laser microdissection microscopy system for cell and development biology$215,000
Funding Body: University of Newcastle

ABI 7500 Real Time PCR System $34,000
Funding Body: NHMRC (National Health & Medical Research Council)

Electron Multiplier Charge-Coupled Device Camera. Hamamatsu EM-CCD Camera C9100-13$29,079
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Keith Jones, Professor Eileen McLaughlin, Professor Dirk Van Helden, Doctor Rick Thorne
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$29,07920102010
GNo:G1000052

2009 (9 grants)

The role of the Anaphase-Promoting Complex activator Cdh1 in mammalian oocytes and aneuploidy$506,250
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Keith Jones, Professor Eileen McLaughlin
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$506,25020092011
GNo:G0188850

An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$495,000
Funding Body: ARC (Australian Research Council)

Elucidation of the signalling pathways during fertilization in mammals$325,000
Funding Body: ARC (Australian Research Council)

Project Team
Conjoint Professor Keith Jones, Dr Olaf Stemmann
SchemeRole
Discovery ProjectsChief Investigator
Total AmountFunding StartFunding Finish
$325,00020092011
GNo:G0188824

HMRI MRSP Infrastructure Grant (09-10) Pregnancy and Reproduction$296,789
Funding Body: Hunter Medical Research Institute

Project Team
Professor Roger Smith, Laureate Professor John Aitken, Conjoint Professor Keith Jones
SchemeRole
NSW MRSP Infrastructure GrantInvestigator
Total AmountFunding StartFunding Finish
$296,78920092009
GNo:G1000642

Confocal Laser Scanning Microscopy for Live Cell Imaging$275,000
Funding Body: ARC (Australian Research Council)

Aging eggs: understanding the molecular mechanisms of declining female fertility$79,489
Funding Body: Hunter Medical Research Institute

Project Team
Conjoint Professor Keith Jones, Professor Eileen McLaughlin
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$79,48920092010
GNo:G0189795

An Advanced Mass Spectrometry Facility for Applications in Proteomics and Organic Chemistry$50,000
Funding Body: ARC (Australian Research Council)

Leica VT1200S - Fully automated vibrating blade microtome$16,209
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Professor Robert Callister, Associate Professor Alan Brichta, Conjoint Professor Keith Jones, Associate Professor Jon Hirst, Doctor Brett Graham, Associate Professor Philip Bolton, Doctor Phil Jobling, Associate Professor Paul Tooney, Doctor Angela McPherson, Doctor Rebecca Lim, Doctor Ramatis De Oliveira, Mr Matthew Walsh
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$16,20920092009
GNo:G0189842

GRC Fertilization and Egg Activation, Plymouth USA, 12-17 July 2009$1,700
Funding Body: University of Newcastle - Faculty of Health and Medicine

Project Team
Conjoint Professor Keith Jones
SchemeRole
Travel GrantChief Investigator
Total AmountFunding StartFunding Finish
$1,70020092009
GNo:G0190133

2008 (4 grants)

The function of gametogenenin in male fertility and embryo genesis$230,500
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Keith Jones, Dr M O'Bryan
SchemeRole
Project GrantChief Investigator
Total AmountFunding StartFunding Finish
$230,50020082010
GNo:G0188417

Olympus Fluoview FV1000-IX81 Microscope$141,970
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Conjoint Professor Keith Jones
SchemeRole
Equipment GrantChief Investigator
Total AmountFunding StartFunding Finish
$141,97020082008
GNo:G0188673

Colibri high-performance LED illumination system for fluorescence live cell microscopy$23,225
Funding Body: NHMRC (National Health & Medical Research Council)

Project Team
Doctor Rick Thorne, Dr Charles De Bock, Professor Xu Dong Zhang, Doctor Lisa Lincz, Professor Gordon Burns, Conjoint Professor Peter Hersey, Professor Dirk Van Helden, Conjoint Professor Keith Jones, Professor Roger Smith
SchemeRole
Equipment GrantInvestigator
Total AmountFunding StartFunding Finish
$23,22520082008
GNo:G0188545

Programmed mammalian oocyte activation: the production line model of primordial follicle development$14,700
Funding Body: University of Newcastle

Project Team
Professor Eileen McLaughlin, Conjoint Professor Keith Jones
SchemeRole
Pilot GrantInvestigator
Total AmountFunding StartFunding Finish
$14,70020082008
GNo:G0189084
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Research Supervision

Number of current supervisions1
Total current UoN PhD EFTSL0.25

For supervisions undertaken at an institution other that the University of Newcastle, the institution name is listed below the program name.

Current Supervision

CommencedProposed
Completion
ProgramSupervisor TypeResearch Title
20102014PhD (Human Physiology)Co-SupervisorSusceptibility of Mammalian Oocytes to Chromosome Segregation Errors with Maternal Aging

Past Supervision

YearProgramSupervisor TypeResearch Title
2013PhD (Human Physiology)Principal SupervisorRole of Fzr1 in Embryogenesis
2013PhD (Human Physiology)Principal SupervisorDNA Repair and the Fanconi Anemia Pathway: Insights into Female Meiosis and Mitosis
2012M Philosophy (Human Physiolog)Principal SupervisorCharacterisation of an Oocyte Specific Knockout Model of Cdh1
2012PhD (Human Physiology)Principal SupervisorControl of Chromosome Segregation in Mouse Oocytes
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Conjoint Professor Keith Jones

Work Phone(02) 4921 6682
Fax(02) 4921 7903
Email
PositionConjoint Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine
The University of Newcastle, Australia
Focus AreaHuman Physiology
Office
MS612,
Medical Sciences,
Callaghan
University Drive
Callaghan NSW 2308
Australia
URL:www.newcastle.edu.au/profile/keith-jones