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Conjoint Professor Keith Jones

Conjoint Professor

School of Biomedical Sciences and Pharmacy (Human Physiology)

Career Summary

Biography

Meiosis is the name given to the two cell divisions germ cells go through following DNA replication in order to produce haploid gametes. Our research focuses on mammalian female meiosis where we use imaging based techniques (Fluorescent Protein chimeras) to explore this process in real-time. We argue that this is an important strategy when examining a dynamic process such as the meiotic cell cycle. Meiosis is important to study because of its unique cell division; in terms of understanding a fundamental cellular developmental biology process; and also because errors in meiotic division lead to aneuploid embryos, the leading cause of early pregnancy loss in humans and the cause of Down's Syndrome. Research Highlights: The mammalian oocyte spends most of its life arrested at prophase of the first meiotic division and we found that APCcdh1 activity was necessary in order to achieve this arrest (Reis et al., Nature Cell Biology, 2006). Recently we extended these observations to show that APCcdh1 also functioned in prometaphase to prevent aneuploidy in maturing oocytes (Reis et al., Nature Cell Biology, 2007). In the first meiotic division chromosome homologues are separated, a unique cell division, and in 2006 we found that during this division separase is needed to inhibit MPF activity (Gorr et al., Nature Cell Biology, 2006. See Nature Cell Biology, News & Views). Following exit from the first meiotic division the egg re-arrests at metaphase of the second meiotic division until sperm break this arrest with a cytosolic calcium signal. Re-arrest at metaphase of the second meiotic division requires the APC inhibitor Emi2 (Madgwick et al., Journal of Cell Biology, 2006).

At fertilization the sister chromatids are separated. Another unequal cell division occurs, and the second polar body is extruded. The fertilized oocyte completes meiosis and forms a zygote. We are very much interested in how the two meiotic divisions are controlled at a molecular level. Our approach is to over-express and visualise gene products by tagging them with a toolkit of Fluorescent Proteins (Cyan; Cerulean; Yellow, Green; Venus; and Red Fluorescent Proteins) and knock them out using antisense morpholinos.

Research Expertise
Mammalian reproductive biology, especially female reproduction with emphasis on oocytes and the meiotic divisions. Cell division and early embryo development, such as the transition from meiosis to mitosis, and the embryonic divisions leading up to implantation. Mitotic cell divisions of cultured cells, and the control of M-phase. Mis-segregation of chromosomes that lead to aneuploidy. Control of the meiotic divisions of oocytes with focus on the mechanisms that control faithful chromosome segregation such as the Spindle Assembly Checkpoint.









Qualifications

  • Doctor of Philosophy, University of Liverpool - UK
  • Bachelor of Science (Biochemistry)(Honours), University of Leeds - UK

Keywords

  • Cell Cycle
  • Cell Division
  • Chromosomes
  • Female Fertility
  • Meiosis
  • Mitosis
  • Oocytes
  • Ovarian Biology
  • Reproductive Biology

Fields of Research

Code Description Percentage
060699 Physiology not elsewhere classified 45
111499 Paediatrics and Reproductive Medicine not elsewhere classified 20
060199 Biochemistry and Cell Biology not elsewhere classified 35
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (3 outputs)

Year Citation Altmetrics Link
2013 Jones KT, Lane SIR, Holt JE, 'Start and Stop Signals of Oocyte Meiotic Maturation', Oogenesis, Springer, London 183-193 (2013) [B1]
DOI 10.1007/978-0-85729-826-3_13
Co-authors Janet Holt
2013 Holt JE, Lane SIR, Jones KT, 'The Control of Meiotic Maturation in Mammalian Oocytes', Gametogenesis, Academic Press, San diego 207-226 (2013) [B1]
DOI 10.1016/B978-0-12-416024-8.00007-6
Citations Scopus - 9Web of Science - 9
Co-authors Janet Holt
2011 Jones KT, 'Anaphase-promoting complex control in female mouse meiosis', Cell Cycle in Development, Springer, Berlin 343-363 (2011) [B1]

Journal article (51 outputs)

Year Citation Altmetrics Link
2014 Yun Y, Lane SIR, Jones KT, 'Premature dyad separation in meiosis II is the major segregation error with maternal age in mouse oocytes', DEVELOPMENT, 141 199-208 (2014) [C1]
DOI 10.1242/dev.100206
Citations Scopus - 7Web of Science - 6
2014 Holt JE, Pye V, Boon E, Stewart JL, Garcia-Higuera I, Moreno S, et al., 'The APC/C activator FZR1 is essential for meiotic prophase I in mice', DEVELOPMENT, 141 1354-U327 (2014) [C1]
DOI 10.1242/dev.104828
Citations Scopus - 1Web of Science - 1
Co-authors Janet Holt, Eileen Mclaughlin
2014 Yun Y, Holt JE, Lane SIR, McLaughlin EA, Merriman JA, Jones KT, 'Reduced ability to recover from spindle disruption and loss of kinetochore spindle assembly checkpoint proteins in oocytes from aged mice', Cell Cycle, 13 1938-1947 (2014) [C1]

Currently, maternal aging in women, based on mouse models, is thought to raise oocyte aneuploidy rates, because chromosome cohesion deteriorates during prophase arrest, and Sgo2, ... [more]

Currently, maternal aging in women, based on mouse models, is thought to raise oocyte aneuploidy rates, because chromosome cohesion deteriorates during prophase arrest, and Sgo2, a protector of centromeric cohesion, is lost. Here we show that the most common mouse strain, C57Bl6/J, is resistant to maternal aging, showing little increase in aneuploidy or Sgo2 loss. Instead it demonstrates significant kinetochore-associated loss in the spindle assembly checkpoint protein Mad2 and phosphorylated Aurora C, which is involved in microtubule-kinetochore error correction. Their loss affects the fidelity of bivalent segregation but only when spindle organization is impaired during oocyte maturation. These findings have an impact clinically regarding the handling of human oocytes ex vivo during assisted reproductive techniques and suggest there is a genetic basis to aneuploidy susceptibility. © 2014 Landes Bioscience.

DOI 10.4161/cc.28897
Citations Scopus - 4Web of Science - 3
Co-authors Janet Holt, Eileen Mclaughlin
2014 Lane SIR, Jones KT, 'Non-canonical function of spindle assembly checkpoint proteins after APC activation reduces aneuploidy in mouse oocytes', NATURE COMMUNICATIONS, 5 (2014) [C1]
DOI 10.1038/ncomms4444
Citations Web of Science - 4
2013 Merriman JA, Lane SIR, Holt JE, Jennings PC, Garcia-Higuera I, Moreno S, et al., 'Reduced Chromosome Cohesion Measured by Interkinetochore Distance Is Associated with Aneuploidy Even in Oocytes from Young Mice', Biology of Reproduction, 88 31-31 (2013) [C1]
DOI 10.1095/biolreprod.112.104786
Citations Scopus - 4Web of Science - 4
Co-authors Janet Holt, Eileen Mclaughlin
2013 Lord T, Nixon B, Jones KT, Aitken RJ, 'Melatonin Prevents Postovulatory Oocyte Aging in the Mouse and Extends the Window for Optimal Fertilization In Vitro', Biology of Reproduction, 88 1-9 (2013) [C1]
DOI 10.1095/biolreprod.112.106450
Citations Scopus - 9Web of Science - 6
Co-authors Brett Nixon, John Aitken
2013 Holt JE, Lane SIR, Jones KT, 'Time-lapse epifluorescence imaging of expressed cRNA to cyclin B1 for studying meiosis i in mouse oocytes', Methods in Molecular Biology, 957 91-106 (2013) [C2]

The first meiotic division of mammalian oocytes physiologically occurs in the ovary in the hours preceding ovulation. Fortunately, oocytes removed from their follicular environmen... [more]

The first meiotic division of mammalian oocytes physiologically occurs in the ovary in the hours preceding ovulation. Fortunately, oocytes removed from their follicular environment will readily undergo this process in culture. Their large size, optical transparency, and efficiency in translating exogenous cRNA make mouse oocytes very amenable to study this process in detail using fluorescence imaging-based techniques. Here we describe the process of microinjecting cRNA to proteins of interest that have been coupled to a fluorescent protein using cyclin B1 as an example. © 2013 Springer Science+Business Media, LLC.

DOI 10.1007/978-1-62703-191-2-6
Citations Scopus - 1
Co-authors Janet Holt
2013 Jamsai D, O'Connor AE, DeBoer KD, Clark BJ, Smith SJ, Browne CM, et al., 'Loss of GGN Leads to Pre-Implantation Embryonic Lethality and Compromised Male Meiotic DNA Double Strand Break Repair in the Mouse', PLOS ONE, 8 (2013) [C1]
DOI 10.1371/journal.pone.0056955
Citations Scopus - 2Web of Science - 2
2012 Merriman-Jones JA, Jennings PC, McLaughlin EA, Jones KT, 'Effect of aging on superovulation efficiency, aneuploidy rates, and sister chromatid cohesion in mice aged up to 15 months', Biology of Reproduction, 86 1-6 (2012) [C1]
Citations Scopus - 25Web of Science - 23
Co-authors Eileen Mclaughlin
2012 Jones KT, Lane SI, 'Chromosomal, metabolic, environmental, and hormonal origins of aneuploidy in mammalian oocytes', Experimental Cell Research, 318 1394-1399 (2012) [C1]
Citations Scopus - 22Web of Science - 20
2012 Liu W, Yin J, Zhao G, Yun Y, Wu S, Jones KT, Lei A, 'Differential regulation of cyclin B1 degradation between the first and second meiotic divisions of bovine oocytes', Theriogenology, 78 1171.e1-1181.e1 (2012) [C1]
Citations Web of Science - 1
2012 Jones KT, Robertson SA, Aitken RJ, 'Reactive oxygen species and sperm function-in sickness and in health', Journal of Andrology, 33 1096-1106 (2012) [C1]
Citations Scopus - 44Web of Science - 34
Co-authors John Aitken
2012 Lane SI, Yun Y, Jones KT, 'Timing of anaphase-promoting complex activation in mouse oocytes is predicted by microtubule-kinetochore attachment but not by bivalent alignment or tension', Development (Cambridge), 139 1947-1955 (2012) [C1]
Citations Scopus - 34Web of Science - 34
2012 Jones KT, 'Meiosis: Mouse eggs do their anaphase topsy-turvy', Current Biology, 22 R153-R155 (2012) [C3]
2012 Holt JE, Lane SI, Jennings PC, Garcia-Higuera I, Moreno S, Jones KT, 'APC FZR1 prevents nondisjunction in mouse oocytes by controlling meiotic spindle assembly timing', Molecular Biology of the Cell, 23 3970-3981 (2012) [C1]
Citations Scopus - 10Web of Science - 10
Co-authors Janet Holt
2012 Seah KYM, Holt JE, Garcia-Higuera I, Moreno S, Jones KT, 'The APC activator fizzy-related-1 (FZR1) is needed for preimplantation mouse embryo development', Journal of Cell Science, 125 6030-6037 (2012) [C1]
Co-authors Janet Holt
2012 Yuen WS, Merriman-Jones JA, O'Bryan MK, Jones KT, 'DNA double strand breaks but not interstrand crosslinks prevent progress through meiosis in fully grown mouse oocytes', PLOS One, 7 e43875 (2012) [C1]
Citations Scopus - 10Web of Science - 10
2011 Lane SI, Jones KT, 'Phosphorylation of histone H3 in 1- and 2-cell embryos', Cell Cycle, 10 17-18 (2011) [C3]
DOI 10.4161/cc.10.1.14221
2011 Chang H-Y, Jennings PC, Stewart JL, Verrills NM, Jones KT, 'Essential role of protein phosphatase 2A in metaphase II arrest and activation of mouse eggs shown by okadaic acid, dominant negative protein phosphatase 2A, and FTY720', Journal of Biological Chemistry, 286 14705-14712 (2011) [C1]
DOI 10.1074/jbc.M110.193227
Citations Scopus - 19Web of Science - 18
Co-authors Nikki Verrills
2011 Jamsai D, Sarraj MA, Merriner DJ, Drummond AE, Jones KT, McLachlan RI, O'Bryan MK, 'GGN1 in the testis and ovary and its variance within the Australian fertile and infertile male population', International Journal of Andrology, 34 624-632 (2011) [C1]
Citations Scopus - 4Web of Science - 5
2011 Jennings PC, Merriman-Jones JA, Beckett EL, Hansbro PM, Jones KT, 'Increased zona pellucida thickness and meiotic spindle disruption in oocytes from cigarette smoking mice', Human Reproduction, 26 878-884 (2011) [C1]
DOI 10.1093/humrep/deq393
Citations Scopus - 16Web of Science - 13
Co-authors Philip Hansbro
2011 Holt JE, Tran SM-T, Stewart JL, Minahan KL, Garcia-Higuera I, Moreno S, Jones KT, 'The APC/C activator FZR1 coordinates the timing of meiotic resumption during prophase I arrest in mammalian oocytes', Development, 138 905-913 (2011) [C1]
DOI 10.1242/dev.059022
Citations Scopus - 18Web of Science - 16
Co-authors Janet Holt
2010 Jones KT, Holt JE, 'BubR1 highlights essential function of Cdh1 in mammalian oocytes', Cell Cycle, 9 1029-1030 (2010) [C3]
Co-authors Janet Holt
2010 Holt JE, Stewart JL, Jones KT, 'Spatial regulation of APC(Cdh1)-induced cyclin B1 degradation maintains G2 arrest in mouse oocytes', Development, 137 1297-1304 (2010) [C1]
DOI 10.1242/dev.047555
Citations Scopus - 31Web of Science - 26
Co-authors Janet Holt
2010 Jones KT, 'Cohesin and Cdk1: An anaphase barricade', Nature Cell Biology, 12 106-108 (2010) [C3]
DOI 10.1038/ncb0210-106
Citations Scopus - 3Web of Science - 3
2010 Lane SI, Chang H-Y, Jennings PC, Jones KT, 'The Aurora kinase inhibitor ZM447439 accelerates first meiosis in mouse oocytes by overriding the spindle assembly checkpoint', Reproduction, 140 521-530 (2010) [C1]
DOI 10.1530/REP-10-0223
Citations Scopus - 34Web of Science - 29
2009 Chang H-Y, Minahan KL, Merriman-Jones JA, Jones KT, 'Calmodulin-dependent protein kinase gamma 3 (CamKII[gamma]3) mediates the cell cycle resumption of metaphase II eggs in mouse', Development, 136 4077-4081 (2009) [C1]
DOI 10.1242/dev.042143
Citations Scopus - 29Web of Science - 27
2009 Holt JE, Jones KT, 'Control of homologous chromosome division in the mammalian oocyte', Molecular Human Reproduction, 15 139-147 (2009) [C1]
DOI 10.1093/molehr/gap007
Citations Scopus - 31Web of Science - 31
Co-authors Janet Holt
2008 Jones KT, 'Meiosis in oocytes: predisposition to aneuploidy and its increased incidence with age', Human Reproduction Update, 14 143-158 (2008) [C1]
DOI 10.1093/humupd/dmm043
Citations Scopus - 98Web of Science - 95
2008 Nabti I, Reis A, Levasseur M, Stemmann O, Jones KT, 'Securin and not CDK1/cyclin B1 regulates sister chromatid disjunction during meiosis II in mouse eggs', Developmental Biology, 321 379-386 (2008) [C1]
DOI 10.1016/j.ydbio.2008.06.036
Citations Scopus - 16Web of Science - 16
2007 Madgwick S, Jones KT, 'How eggs arrest at metaphase II: MPF stabilisation plus APC/C inhibition equals Cytostatic Factor', Cell Division, 2 1-7 (2007) [C1]
DOI 10.1186/1747-1028-2-4
2007 Reis A, Madgwick S, Chang H-Y, Nabti I, Levasseur M, Jones KT, 'Prometaphase APCcdh1 activity prevents non-disjunction in mammalian oocytes', Nature Cell Biology, 9 1192-1198 (2007) [C1]
DOI 10.1038/ncb1640
2007 Jones KT, Swann K, 'Composition of sea urchin egg homogenate determines its potency to inositol trisphosphate and cyclic ADPRibose-induced Ca2+ release', Biochemical and Biophysical Research Communications, 360 815-820 (2007) [C1]
DOI 10.1016/j.bbrc.2007.06.134
2007 Levasseur M, Carroll M, Jones KT, McDougall A, 'A novel mechanism controls the Ca2+ oscillations triggered by activation of ascidian eggs and has an absolute requirement for Cdk1 activity', Journal of Cell Science, 120 1763-1771 (2007) [C1]
DOI 10.1242/jcs.003012
2007 Gardner AJ, Knott JG, Jones KT, Evans JP, 'CaMKII can participate in but is not sufficient for the establishment of the membrane block to polyspermy in mouse eggs', Journal of Cellular Physiology, 212 275-280 (2007) [C1]
DOI 10.1002/jcp.21046
Citations Scopus - 15
2007 Jones KT, 'Intracellular calcium in the fertilization and development of mammalian eggs', Journal of Cellular Physiology, 34 1084-1089 (2007) [C1]
DOI 10.1111/j.1440-1681.2007.04726.x
2006 Madgwick S, Hansen DV, Levasseur M, Jackson PK, Jones KT, 'Mouse Emi2 Is Required to Enter Meiosis II by Reestablishing Cyclin B1 During Interkinesis', The Journal of Cell Biology, 174 791-801 (2006) [C1]
DOI 10.1083/jcb.200604140
2006 Gorr IH, Reis A, Boos D, Wühr M, Madgwick S, Jones KT, Stemmann O, 'Essential CDK1-inhibitory role for separase during meiosis I in vertebrate oocytes', Nature Cell Biology, 8 1035-1037 (2006) [C1]
DOI 10.1038/ncb1467
2006 Reis A, Chang H-Y, Levasseur M, Jones KT, 'APCcdh1 activity in mouse oocytes prevents entry into the first meiotic division', Nature Cell Biology, 8 539-540 (2006) [C1]
2006 Reis A, Levasseur M, Chang H-Y, Elliot DJ, Jones KT, 'The CRY box: A second APCcdh1-dependent degron in mammalian cdc20', EMBO Reports, 7 1040-1045 (2006) [C1]
DOI 10.1038/sj.embor.7400772
2006 Knott JG, Gardner AJ, Madgwick S, Jones KT, Williams CJ, Schultz RM, 'Calmodulin-dependent protein kinase II triggers mouse egg activation and embryo development in the absence of Ca2+ oscillations', Developmental Biology, 296 388-395 (2006) [C1]
DOI 10.1016/j.ydbio.2006.06.004
Citations Scopus - 43
2005 Madgwick S, Levasseur M, Jones KT, 'Calmodulin-dependent protein kinase II, and not protein kinase C, is sufficient for triggering cell-cycle resumption in mammalian eggs', Journal of Cell Science, 118 3849-3859 (2005) [C1]
DOI 10.1242/jcs.02506
2005 Coward K, Ponting CP, Chang H-Y, Hibbitt O, Savolainen P, Jones KT, Parrington J, 'Phospholipase C{zeta}, the trigger of egg activation in mammals, is present in a non-mammalian species', Reproduction, 130 157-163 (2005) [C1]
DOI 10.1530/rep.1.00707
2005 Jones KT, 'Mammalian egg activation: from Ca2+ spiking to cell cycle progression', Reproduction, 130 813-823 (2005) [C1]
DOI 10.1530/rep.1.00710
2004 Hyslop LA, Nixon VL, Levasseur M, Chapman F, Chiba K, McDougall A, et al., 'Ca2+-promoted cyclin B1 degradation in mouse oocytes requires the establishment of a metaphase arrest', Developmental Biology, 269 206-219 (2004) [C1]
DOI 10.1016/j.ydbio.2004.01.030
2004 Madgwick S, Nixon VL, Chang H-Y, Herbert M, Levassuer M, Jones KT, 'Maintenance of sister chromatid attachment in mouse eggs through maturation-promoting factor activity', Developmental Biology, 275 68-81 (2004) [C1]
DOI 10.1016/j.ydbio.2004.07.024
2004 Chang H-Y, Levasseur M, Jones KT, 'Degradation of APCcdc20 and APCcdh1 substrates during the second meiotic division in mouse eggs', Journal of Cell Science, 117 6289-6296 (2004) [C1]
DOI 10.1242/jcs.01567
2004 Venables JP, Dalgliesh C, Paronetto MP, Skitt L, Thornton JK, Saunders PT, et al., 'SIAH1 targets the alternative splicing factor T-STAR for degradation by the proteasome', Human Molecular Genetics, 13 1525-1534 (2004) [C1]
DOI 10.1093/hmg/ddh165
2004 Jones KT, 'Turning it on and off: M-phase promoting factor during meiotic maturation and fertilization', Molecular Human Reproduction, 10 1-5 (2004) [C1]
DOI 10.1093/molehr/gah009
2003 Carroll M, Levasseur M, Whitaker M, Jones KT, McDougall A, 'Exploring the mechanism of action of the sperm-triggered calcium-wave pacemaker in ascidian zygotes', Journal of Cell Science, 116 4997-5004 (2003) [C1]
DOI 10.1242/jcs.00846
2003 Soeller C, Jacobs MD, Donaldson PJ, Cannell MB, Jones KT, Ellis-Davies GCR, 'Application of two-photon flash photolysis to reveal intercellular communication and intracellular Ca2+ movements.', Journal of Biomedical Optics, 8 418-427 (2003) [C1]
DOI 10.1117/1.1582468
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Conference (5 outputs)

Year Citation Altmetrics Link
2010 Chang H-Y, Jennings PC, Jones KT, 'The use of okadaic acid and FTY720 to examine the role of PP2A in the metaphase II arrest of mouse eggs', The American Society for Cell Biology 50th Annual Meeting Abstracts, Phildelphia, PA (2010) [E3]
2010 Jones KT, 'CDH1: A cell cycle protein involved in female meiosis and prevention of aneuploidy', Reproduction, Fertility and Development, Sydney (2010) [E3]
DOI 10.1071/SRB10Abs032
2010 Hopkins LA, Pye VJ, Fraser BA, Holt JE, Jones KT, McLaughlin EA, 'The Role of Fizzy Related 1 in Male Meiosis', Reproduction, Fertility and Development, Sydney (2010) [E3]
Co-authors Eileen Mclaughlin, Janet Holt
2010 Jennings PC, Jones KT, 'Investigating the Role of Cyclin A2 During Oocyte Meiosis', Reproduction, Fertility and Development, Sydney (2010) [E3]
2009 Jones KT, Weaver J, Holt JE, 'The mechanism by which fizzy-related (Fzr1) controls pro-phase 1 arrest in mouse oocytes', Biology of Reproduction, Pittsburgh, PA (2009) [E3]
Co-authors Janet Holt
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Grants and Funding

Summary

Number of grants 28
Total funding $5,058,322

Click on a grant title below to expand the full details for that specific grant.


20123 grants / $652,134

Pregnancy and Reproduction MRSP 2011-12 $369,134

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Roger Smith, Laureate Professor John Aitken, Conjoint Professor Keith Jones
Scheme NSW MRSP Infrastructure Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1101192
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Project EVA: an environmentally responsible facility for interdisciplinary supercomputing applications$263,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Pablo Moscato, Laureate Professor Jon Borwein, Conjoint Professor Keith Jones, Conjoint Professor Chris Levi, Professor Mark Parsons, Professor Michael Ostwald, Professor Hugh Craig, Conjoint Professor Peter Greer, Associate Professor Stephan Chalup, Associate Professor Regina Berretta
Scheme Equipment Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1100627
Type Of Funding Internal
Category INTE
UON Y

Regulation of the cell cycle by phosphorylation dependent targeting of CaMKII$20,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Nikki Verrills, Doctor Kathryn Skelding, Emeritus Professor John Rostas, Associate Professor Phillip Dickson, Conjoint Professor Keith Jones
Scheme Near Miss Grant
Role Investigator
Funding Start 2012
Funding Finish 2012
GNo G1200679
Type Of Funding Internal
Category INTE
UON Y

20117 grants / $960,000

Gamete-specific knockout of Fizzy-Related to examine its meiotic role in oocytes and sperm$600,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Professor Sergio Moreno
Scheme Discovery Projects
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1000020
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

An Advanced Mass Spectrometer for Applications in Phospho-Proteomics, Glycomics and Top-Down Sequencing of Proteins$250,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Doctor Mark Baker, Laureate Professor John Aitken, Professor Roger Smith, Conjoint Professor Keith Jones, Conjoint Professor Ray Rose, Professor Lois Salamonsen
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1000632
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

SCIREQ FlexiVentFX system + FlexiVentFX extension$45,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Phil Hansbro, Laureate Professor Paul Foster, Professor Joerg Mattes, Doctor Simon Keely, Doctor Jay Horvat, Doctor Nicole Hansbro, Doctor Ming Yang, Doctor Catherine Ptaschinski, Doctor Kelly Asquith, Doctor Gough Au, Conjoint Professor Peter Wark, Laureate Professor John Aitken, Conjoint Professor Keith Jones, Professor Roger Smith, Professor Judith Black, Professor Rakesh Kumar, Professor Paul Hertzog
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100037
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Factors affecting the quality of mammalian eggs when females age.$25,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Conjoint Professor Keith Jones
Scheme Near Miss Grant
Role Lead
Funding Start 2011
Funding Finish 2011
GNo G1001042
Type Of Funding Internal
Category INTE
UON Y

Eppendorf mastercycler pro with thermomixer comfort and 5430R centrifuge$15,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Eileen McLaughlin, Professor Peter Lewis, Professor Adam McCluskey, Conjoint Professor Keith Jones, Associate Professor Brett Nixon, Doctor Shaun Roman, Doctor Jennette Sakoff, Doctor Ian Grainge, Doctor Janet Holt, Doctor Xiao Yang
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100028
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

An Advanced Mass Spectrometer for Applications in Phospho-Proteomics, Glycomics and Top-Down Sequencing of Proteins$15,000

Funding body: Prince Henry's Institute of Medical Research

Funding body Prince Henry's Institute of Medical Research
Project Team Doctor Mark Baker, Laureate Professor John Aitken, Professor Roger Smith, Conjoint Professor Keith Jones, Conjoint Professor Ray Rose, Professor Lois Salamonsen
Scheme Linkage Infrastructure Equipment & Facilities (LIEF) Partner funding
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100844
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

IMPLEN NanoPhotometer pearl$10,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Professor Alan Brichta, Emeritus Professor John Rostas, Emeritus Professor Patricia Michie, Conjoint Professor Keith Jones, Professor Ulli Schall, Associate Professor Phillip Dickson, Doctor Frederick Walker, Doctor Rick Thorne, Doctor Chris Dayas, Doctor Nikki Verrills, Doctor Janet Holt, Doctor Severine Roselli, Doctor Kathryn Skelding, Doctor Jude Weidenhofer, Associate Professor Liz Milward, Doctor Charles De Bock, Doctor Julie Merriman-Jones, Doctor Jing Qin Wu, Doctor Bing Liu, Mr Dan Johnstone, Ms Belinda Goldie, Doctor Natalie Beveridge
Scheme Equipment Grant
Role Investigator
Funding Start 2011
Funding Finish 2011
GNo G1100030
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20105 grants / $990,356

HMRI MRSP Infrastructure Grant (10-11) - PREGNANCY & REPRODUCTION$362,277

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Roger Smith, Laureate Professor John Aitken, Conjoint Professor Keith Jones
Scheme NSW MRSP Infrastructure Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1100474
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Laser microdissection microscopy system for cell and development biology$350,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Professor Eileen McLaughlin, Conjoint Professor Keith Jones, Laureate Professor John Aitken, Associate Professor Brett Nixon, Doctor Shaun Roman, Professor Alan Brichta, Doctor Rick Thorne, Doctor Doug Smith, Associate Professor David McCurdy, Conjoint Professor Ray Rose, Professor Christopher Grof, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Doctor Brett Graham, Associate Professor Paul Tooney, Professor Roger Smith, Laureate Professor Paul Foster, Professor Trevor Day, Professor Robert Callister
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G0190369
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

ABI 7500 Real Time PCR System $34,000

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Rick Thorne, Doctor Nikki Verrills, Conjoint Associate Professor Murray Cairns, Associate Professor Paul Tooney, Doctor Doug Smith, Professor Gordon Burns, Emeritus Professor Leonie Ashman, Conjoint Professor Keith Jones, Doctor Charles De Bock, Doctor Chris Dayas, Doctor Brett Graham, Doctor Martin Horan, Doctor Rebecca Lim, Doctor Severine Roselli, Doctor Larisa Bobrovskaya, Doctor Kathryn Skelding, Doctor Frederick Walker, Doctor Jude Weidenhofer, Associate Professor Philip Bolton, Professor Alan Brichta, Professor Robert Callister, Professor Trevor Day, Associate Professor Phillip Dickson, Professor Manohar Garg, Doctor Phil Jobling, Associate Professor Derek Laver, Associate Professor Eugene Nalivaiko, Emeritus Professor John Rostas
Scheme Equipment Grant
Role Investigator
Funding Start 2010
Funding Finish 2010
GNo G1000055
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Electron Multiplier Charge-Coupled Device Camera. Hamamatsu EM-CCD Camera C9100-13$29,079

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Keith Jones, Professor Eileen McLaughlin, Professor Dirk Van Helden, Doctor Rick Thorne
Scheme Equipment Grant
Role Lead
Funding Start 2010
Funding Finish 2010
GNo G1000052
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20099 grants / $2,045,437

The role of the Anaphase-Promoting Complex activator Cdh1 in mammalian oocytes and aneuploidy$506,250

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Keith Jones, Professor Eileen McLaughlin
Scheme Project Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0188850
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Elucidation of the signalling pathways during fertilization in mammals$325,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Conjoint Professor Keith Jones, Dr Olaf Stemmann
Scheme Discovery Projects
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0188824
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

HMRI MRSP Infrastructure Grant (09-10) Pregnancy and Reproduction$296,789

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Professor Roger Smith, Laureate Professor John Aitken, Conjoint Professor Keith Jones
Scheme NSW MRSP Infrastructure Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G1000642
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Confocal Laser Scanning Microscopy for Live Cell Imaging$275,000

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Conjoint Professor Keith Jones, Professor Eileen McLaughlin, Laureate Professor John Aitken, Conjoint Professor Ray Rose, Emeritus Professor John Patrick, Conjoint Professor Christina Offler, Associate Professor David McCurdy, Emeritus Professor Leonie Ashman, Professor Gordon Burns, Professor Dirk Van Helden, Doctor Nikki Verrills, Associate Professor Brett Nixon, Doctor Shaun Roman, Associate Professor Yong-Ling Ruan, Doctor Rick Thorne, Professor Mike Calford
Scheme Linkage Infrastructure Equipment & Facilities (LIEF)
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0189038
Type Of Funding Scheme excluded from IGS
Category EXCL
UON Y

Aging eggs: understanding the molecular mechanisms of declining female fertility$79,489

Funding body: Hunter Medical Research Institute

Funding body Hunter Medical Research Institute
Project Team Conjoint Professor Keith Jones, Professor Eileen McLaughlin
Scheme Project Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0189795
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Leica VT1200S - Fully automated vibrating blade microtome$16,209

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Professor Robert Callister, Professor Alan Brichta, Conjoint Professor Keith Jones, Professor Jon Hirst, Doctor Brett Graham, Associate Professor Philip Bolton, Doctor Phil Jobling, Associate Professor Paul Tooney, Doctor Angela McPherson, Doctor Rebecca Lim, Doctor Ramatis De Oliveira, Mr Matthew Walsh
Scheme Equipment Grant
Role Investigator
Funding Start 2009
Funding Finish 2009
GNo G0189842
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

GRC Fertilization and Egg Activation, Plymouth USA, 12-17 July 2009$1,700

Funding body: University of Newcastle - Faculty of Health and Medicine

Funding body University of Newcastle - Faculty of Health and Medicine
Project Team Conjoint Professor Keith Jones
Scheme Travel Grant
Role Lead
Funding Start 2009
Funding Finish 2009
GNo G0190133
Type Of Funding Internal
Category INTE
UON Y

20084 grants / $410,395

The function of gametogenenin in male fertility and embryo genesis$230,500

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Keith Jones, Dr M O'Bryan
Scheme Project Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188417
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Olympus Fluoview FV1000-IX81 Microscope$141,970

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Conjoint Professor Keith Jones
Scheme Equipment Grant
Role Lead
Funding Start 2008
Funding Finish 2008
GNo G0188673
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Colibri high-performance LED illumination system for fluorescence live cell microscopy$23,225

Funding body: NHMRC (National Health & Medical Research Council)

Funding body NHMRC (National Health & Medical Research Council)
Project Team Doctor Rick Thorne, Dr Charles De Bock, Professor Xu Dong Zhang, Doctor Lisa Lincz, Professor Gordon Burns, Conjoint Professor Peter Hersey, Professor Dirk Van Helden, Conjoint Professor Keith Jones, Professor Roger Smith
Scheme Equipment Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0188545
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

Programmed mammalian oocyte activation: the production line model of primordial follicle development$14,700

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Eileen McLaughlin, Conjoint Professor Keith Jones
Scheme Pilot Grant
Role Investigator
Funding Start 2008
Funding Finish 2008
GNo G0189084
Type Of Funding Internal
Category INTE
UON Y
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Research Supervision

Number of supervisions

Completed5
Current0

Past Supervision

Year Level of Study Research Title / Program / Supervisor Type
2015 PhD Susceptibility of Mammalian Oocytes to Chromosome Segregation Errors with Maternal Aging
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Co-Supervisor
2013 PhD Role of Fzr1 in Embryogenesis
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2013 PhD DNA Repair and the Fanconi Anemia Pathway: Insights into Female Meiosis and Mitosis
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2012 PhD Control of Chromosome Segregation in Mouse Oocytes
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
2012 Masters Characterisation of an Oocyte Specific Knockout Model of Cdh1
Human Biology, Faculty of Health and Medicine, The University of Newcastle
Principal Supervisor
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Conjoint Professor Keith Jones

Position

Conjoint Professor
School of Biomedical Sciences and Pharmacy
Faculty of Health and Medicine

Focus area

Human Physiology

Contact Details

Email keith.jones@newcastle.edu.au
Phone (02) 4921 6682
Fax (02) 4921 7903

Office

Room MS612
Building Medical Sciences
Location Callaghan
University Drive
Callaghan, NSW 2308
Australia
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