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Professor Caroline McMillen

Vice-Chancellor

Office of the Vice-Chancellor

Professor Caroline McMillen, MA, DPhil(Oxon), MB, BChir(Cantab)

Vice-Chancellor Professor Caroline McMillen

Vice-Chancellor and President, University of Newcastle

Professor Caroline McMillen joined the University of Newcastle as Vice-Chancellor and President in October 2011. 

Professor McMillen has dedicated almost 30 years to the higher education sector, holding leadership roles across research, innovation and teaching. She holds a Bachelor of Arts (Hons) and Doctor of Philosophy from Oxford University, and completed her medical training at the University of Cambridge.

In 1983, Professor McMillen moved to Australia to lecture at Monash University. In 1992, she was appointed Professor, Chair and Head of the Department of Physiology at the University of Adelaide. In 2005, she accepted the position of Deputy Vice-Chancellor and Vice President: Research and Innovation at the University of South Australia, a position she held until her move to Newcastle.

As a biomedical researcher, Professor McMillen is internationally recognised for her work into the impact of the nutritional environment before birth on the risk of developing cardiovascular disease and obesity in adult life.

Her research group has been funded continuously for two decades by both the Australian Research Council and the National Health and Medical Research Council. She has published more than 200 publications and been invited to present at more than 70 international and national meetings. Professor McMillen is also currently the Chair of the Endocrinology, Reproduction and Development Commission of the International Union of Physiological Societies - the only Australian Chair on this international body.

Over her career, Professor McMillen has trained more than 50 Honours and PhD students who have gone on to win national honours and fellowships and made significant contributions in diverse careers, including research, industry, medicine, dentistry, veterinary science and education.

She has served on state government groups focused on: building innovation, climate change, manufacturing and the resources industry. Professor McMillen was a member of the Prime Minister's Science, Engineering and Innovation Council Working Group on Aboriginal and Torres Strait Islanders focusing on maternal and peri-natal health. She has served as Chair of the Australian Research Council and National Health and Medical Research Council's grant review panels.

Professor McMillen is committed to building collaborative partnerships between universities, government, industry and communities that directly contribute to the economic, environmental, social and cultural health of Australia.



Prof Caroline McMillen

Professor Caroline McMillen, MA, DPhil(Oxon), MB, BChir(Cantab)

Vice-Chancellor Professor Caroline McMillen has dedicated almost 30 years to higher education, holding leadership roles across research, innovation and teaching

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Career Summary

Biography

Professor Caroline McMillen joined the University of Newcastle as Vice-Chancellor and President in October 2011.

Professor McMillen has dedicated almost 30 years to the higher education sector, holding leadership roles across research, innovation and teaching. She holds a Bachelor of Arts (Hons) and Doctor of Philosophy from Oxford University, and completed her medical training at the University of Cambridge.

In 1983, Professor McMillen moved to Australia to lecture at Monash University. In 1992, she was appointed Professor, Chair and Head of the Department of Physiology at the University of Adelaide. In 2005, she accepted the position of Deputy Vice-Chancellor and Vice President: Research and Innovation at the University of South Australia, a position she held until her move to Newcastle.

As a biomedical researcher, Professor McMillen is internationally recognised for her work into the impact of the nutritional environment before birth on the risk of developing cardiovascular disease and obesity in adult life.

Her research group has been funded continuously for two decades by both the Australian Research Council and the National Health and Medical Research Council. She has published more than 200 publications and been invited to present at more than 70 international and national meetings. Professor McMillen is also currently the Chair of the Endocrinology, Reproduction and Development Commission of the International Union of Physiological Societies - the only Australian Chair on this international body.

Research Expertise

Professor McMillen has an international reputation for her work in development and the impact of the early nutritional environment on the programming of later obesity, insulin resistance and cardiovascular disease. The work of her Early Origins of Health Research Group has been funded by both the NHMRC and ARC since 1990 and she has published 203 research articles (book chapters, edited proceedings and journal papers) with papers published in journals including Physiology Reviews (IF 35.0), Journal of Clinical Investigation (IF 16.56), The FASEB Journal (IF 7.05), Endocrinology (IF 5.0) and the Journal of Physiology (IF 4.65). Her work has been cited more than 4,100 times (h index 35), and she has received invitations to present more than 70 Plenary or Symposia lectures at international and national conferences. She was selected by the NHMRC to contribute to the ‘Great Minds in Health and Medical Research’ podcast series in 2008 and was elected to the Council of the International Union of Physiologists in 2009.



Teaching Expertise

Between 1983-1991 Professor McMillen convened, taught and assessed in a range of second and third year physiology courses in Medicine and Science at Monash University. In 1991 Professor McMillen initiated, designed and tutored the new Clinical and Communication Skills Unit which was singled out for commendation in the subsequent Australian Medical Council Accreditation of the Monash Medical Course. Between 1989 and 1991, Professor McMillen played a major role in the development of the new medical curriculum and was involved in a range of Faculty Working Parties in Curriculum Development.

Professor McMillen convened, taught and assessed in a range of first, second and third year courses in science, medicine and dentistry at the University of Adelaide between 1992-2005. Experience with a range of learning and teaching methods including didactic lectures (50-300 students), journal club style tutorials, problem based learning tutorials with medical students and biomedical students, research project practicals for small (4-6 students) or large (24-28 students) groups and the delivery of a range of non didactic workshops for both Honours and PhD students. She was course coordinator for a range of courses including a third year major course in physiology (~100 students) and the Honours in Physiology program (15-25 students). Her contact time with students was usually around 200–250 hours in any year.



Administrative Expertise



Collaborations

Over her career, Professor McMillen has trained more than 50 Honours and PhD students who have gone on to win national honours and fellowships and made significant contributions in diverse careers, including research, industry, medicine, dentistry, veterinary science and education.

Professor McMillen is a member of the national Automotive Industry Innovation Council and a Board member of the Cooperative Research Centre for Advanced Automotive Technology.

She has served on state government groups focused on: building innovation, climate change, manufacturing and the resources industry. Professor McMillen was a member of the Prime Minister's Science, Engineering and Innovation Council Working Group on Aboriginal and Torres Strait Islanders focusing on maternal and peri-natal health. She has served as Chair of the Australian Research Council and National Health and Medical Research Council's grant review panels.

Professor McMillen is committed to building collaborative partnerships between universities, government, industry and communities that directly contribute to the economic, environmental, social and cultural health of Australia.


Qualifications

  • PhD, University of Oxford - UK
  • Bachelor of Physiological Science (Honours), University of Oxford - UK
  • Master of Arts, University of Oxford - UK
  • Bachelor of Medicine, Bachelor of Surgery, University of Cambridge - UK

Keywords

  • Biology of reproduction
  • Early origins of obesity
  • Endocrinology
  • Paediatric Research
  • Physiology
  • Pregnancy

Fields of Research

CodeDescriptionPercentage
060699Physiology not elsewhere classified20
111699Medical Physiology not elsewhere classified80

Professional Experience

UON Appointment

DatesTitleOrganisation / Department
13/02/2015 - 30/10/2016Vice-ChancellorUniversity of Newcastle
Office of the Vice-Chancellor
Australia
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (2 outputs)

YearCitationAltmetricsLink
2009McMillen IC, Rattanatray L, Duffield JA, Morrison JL, MacLaughlin SM, Gentili S, Muhlhausler BS, 'The early origins of later obesity: Pathways and mechanisms', Early Nutrition Programming and Health Outcomes in Later Life: Obesity and beyond, Springer New York LLC, New York, New York/USA 71-82 (2009) [B1]
DOI10.1007/978-1-4020-9173-5_8
CitationsScopus - 53Web of Science - 54
1979Jenkin G, McMillen IC, Thorburn GD, 'The development of fetal hypothalamic-pituitary gonadal adrenal function', Fetal Endocrinology, S. Karger AG, Basel, Switzerland 58-90 (1979) [B1]
CitationsScopus - 1

Journal article (220 outputs)

YearCitationAltmetricsLink
2015Zhang S, Regnault TR, Barker PL, Botting KJ, McMillen IC, McMillan CM, et al., 'Placental adaptations in growth restriction.', Nutrients, 7 360-389 (2015)
DOI10.3390/nu7010360
2015Padhee M, Zhang S, Lie S, Wang KC, Botting KJ, McMillen IC, et al., 'The periconceptional environment and cardiovascular disease: does in vitro embryo culture and transfer influence cardiovascular development and health?', Nutrients, 7 1378-1425 (2015)
DOI10.3390/nu7031378
2015Hernandez-Medrano JH, Copping KJ, Hoare A, Wapanaar W, Grivell R, Kuchel T, et al., 'Gestational dietary protein is associated with sex specific decrease in blood flow, fetal heart growth and post-natal blood pressure of progeny.', PLoS One, 10 e0125694 (2015)
DOI10.1371/journal.pone.0125694Author URL
2014Lie S, Morrison JL, Williams-Wyss O, Suter CM, Humphreys DT, Ozanne SE, et al., 'Periconceptional Undernutrition Programs Changes in Insulin-Signaling Molecules and MicroRNAs in Skeletal Muscle in Singleton and Twin Fetal Sheep', BIOLOGY OF REPRODUCTION, 90 (2014) [C1]
DOI10.1095/biolreprod.113.109751Author URL
CitationsWeb of Science - 2
2014Lie S, Morrison JL, Williams-Wyss O, Suter CM, Humphreys DT, Ozanne SE, et al., 'Impact of embryo number and maternal undernutrition around the time of conception on insulin signaling and gluconeogenic factors and microRNAs in the liver of fetal sheep', AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 306 E1013-E1024 (2014) [C1]
DOI10.1152/ajpendo.00553.2013Author URL
CitationsWeb of Science - 2
2014Copping KJ, Hoare A, Callaghan M, Mcmillen IC, Rodgers RJ, Perry VEA, 'Fetal programming in 2-year-old calving heifers: Peri-conception and first trimester protein restriction alters fetal growth in a gender-specific manner', Animal Production Science, 54 1333-1337 (2014) [C1]

Protein restriction in early bovine gestation affects post-natal reproduction and production traits in progeny. This experiment evaluated the effects of dietary protein restriction during the peri-conception period and first trimester in yearling heifers on conceptus growth and development; this period of dietary intervention being earlier than any previous bovine fetal programming studies. Three-hundred and sixty primiparous 12-month-old Santa Gertrudis heifers were individually fed high [14% crude protein (CP)] or low (7% CP) diets for 60 days before conception. At 23 days post-conception (dpc), each high (HPERI) or low (LPERI) group was again split into high (HPOST) or low (LPOST) protein groups yielding four treatment groups in a 2 × 2 factorial design. From the end of the first trimester of gestation (98dpc), the pregnant heifers were individually fed a 12% CP diet until parturition. Forty-six fetuses were excised at 98dpc. Sixty-four heifers went on to calve. Conceptus development was assessed via transrectal ultrasound from 36dpc, fetal necropsy at 98dpc and live calf measures at term. At 36dpc, HPERI diet increased fetal crown-rump length (CRL) (P < 0.05) and at the 60dpc scan, biparietal diameter (BPD) tended to be increased by HPOST diet (P < 0.1) though the greater effect upon BPD was still the HPERI diet (P < 0.05). At 60dpc, BPD in the male fetus was affected by the peri-conception diet (P < 0.05), while in females, BPD was not different among nutritional groups. These ultrasound measures of fetal growth were validated by measures of the excised fetus at 98dpc. Fetal weight was heavier (P < 0.01) in those whose mothers were fed the HPOST diet than their LPOST counterparts. Males fetuses were heavier than female fetuses (P < 0.001). Fetal CRL was increased by HPERI diet (P < 0.05) and tended to be increased by HPOST diet (P < 0.1). Fetal BPD tended to be increased by HPERI diet (P < 0.1). In males, BPD tended to be increased in those fetuses whose mothers were fed HPERI (P < 0.1). For females, maternal nutrition during PERI or POST did not affect BPD at 98dpc (P > 0.1). At term, no dietary effect on birthweight was observed (P > 0.1) and males were not heavier than females (P > 0.1). These results suggest that maternal protein intake during the peri-conception (-60 to 23dpc) and first trimester (24-98dpc) may influence early conceptus growth and development in the bovine. The long-term effects on offspring metabolism and post-natal development of this dietary intervention are yet to be determined. © CSIRO 2014.

DOI10.1071/AN14278
CitationsScopus - 2Web of Science - 2
2014Williams-Wyss O, Zhang S, MacLaughlin SM, Kleemann D, Walker SK, Suter CM, et al., 'Embryo number and periconceptional undernutrition in the sheep have differential effects on adrenal epigenotype, growth, and development.', Am J Physiol Endocrinol Metab, 307 E141-E150 (2014) [C1]
DOI10.1152/ajpendo.00051.2012Author URL
2013Nicholas LM, Rattanatray L, MacLaughlin SM, Ozanne SE, Kleemann DO, Walker SK, et al., 'Differential effects of maternal obesity and weight loss in the periconceptional period on the epigenetic regulation of hepatic insulin-signaling pathways in the offspring', FASEB Journal, 27 3786-3796 (2013) [C1]

Our aim was to determine the effect of exposure to maternal obesity or to maternal weight loss around conception on the programming of hepatic insulin signaling in the offspring. We used an embryo transfer model in sheep to investigate the effects of exposure to either maternal obesity or to weight loss in normal and obese mothers preceding and for 1 wk after conception on the expression of hepatic insulin-signaling and gluconeogenic factors and key miRNAs involved in insulin signaling in the offspring. We found that exposure to maternal obesity resulted in increased hepatic miR-29b (P<0.05), miR-103 (P<0.01), and miR-107 (P<0.05) expression, a decrease in IR (P<0.05), phopsho- Akt (P<0.01), and phospho-FoxO1 (P<0.01) abundance, and a paradoxical decrease in 11ßHSD1 (P<0.05), PEPCK-C (P<0.01), and PEPCK-M (P<0.05) expression in lambs. These changes were ablated by a period of moderate dietary restriction imposed during the periconceptional period. Maternal dietary restriction alone also resulted in decreased abundance of a separate subset of hepatic insulin-signaling molecules, namely, IRS1 (P<0.05), PDK1 (P<0.01), phospho-PDK1 (P<0.05), and aPKC ¿ (P<0.05) and in decreased PEPCK-C (P<0.01) and G6Pase (P<0.01) expression in the lamb. Our findings highlight the sensitivity of the epigenome to maternal nutrition around conception and the need for dietary interventions that maximize metabolic benefits and minimize metabolic costs for the next generation.-Nicholas, L. M., Rattanatray, L., MacLaughlin, S. M., Ozanne, S. E., Kleemann, D. O.,Walker, S. K., Morrison, J. L., Zhang, S., Muhlhausler, B. S., Martin-Gronert, M. S., McMillen, I. C. Differential effects of maternal obesity and weight loss in the periconceptional period on the epigenetic regulation of hepatic insulin-signaling pathways in the offspring. © FASEB.

DOI10.1096/fj.13-227918
CitationsScopus - 18Web of Science - 15
2013Zhang S, Morrison JL, Gill A, Rattanatray L, MacLaughlin SM, Kleemann D, et al., 'Maternal Dietary Restriction During the Periconceptional Period in Normal-Weight or Obese Ewes Results in Adrenocortical Hypertrophy, an Up-Regulation of the JAK/STAT and Down-Regulation of the IGF1R Signaling Pathways in the Adrenal of the Postnatal Lamb', ENDOCRINOLOGY, 154 4650-4662 (2013) [C1]
DOI10.1210/en.2013-1414Author URL
CitationsScopus - 1Web of Science - 2
2013Molloy P, Samaras K, Muhlhausler B, McMillen C, 'From the CSIRO Preventative Health Flagship', MEDICAL JOURNAL OF AUSTRALIA, 198 182-182 (2013) [C3]
DOI10.5694/mja13.10098Author URL
2013Wang KCW, Lim CH, McMillen IC, Duffield JA, Brooks DA, Morrison JL, 'Alteration of cardiac glucose metabolism in association to low birth weight: Experimental evidence in lambs with left ventricular hypertrophy', Metabolism: Clinical and Experimental, 62 1662-1672 (2013) [C1]

Objective Intrauterine growth restriction that results in low birth weight (LBW) has been linked to the onset of pathological cardiac hypertrophy. An altered transition from a fetal to an adult energy metabolism phenotype, with increased reliance on glucose rather than fatty acids for energy production, could help explain this connection. We have therefore investigated cardiac metabolism in relation to left ventricular hypertrophy in LBW lambs, at 21 days after birth. Materials/Methods The expression of regulatory molecules involved in cardiac glucose and fatty acid metabolism was measured using real-time PCR and Western blotting. A section of the left ventricle was fixed for Periodic Acid Schiff staining to determine tissue glycogen content. Results There was increased abundance of insulin signalling pathway proteins (phospho-insulin receptor, insulin receptor and phospho-Akt) and the glucose transporter (GLUT)-1, but no change in GLUT-4 or glycogen content in the heart of LBW compared to ABW lambs. There was, however, increased abundance of cardiac pyruvate dehydrogenase kinase 4 (PDK-4) in LBW compared to ABW lambs. There were no significant changes in the mRNA expression of components of the peroxisome proliferator activated receptor regulatory complex or proteins involved in fatty acid metabolism. Conclusion We concluded that LBW induced left ventricular hypertrophy was associated with increased GLUT-1 and PDK-4, suggesting increased glucose uptake, but decreased efficacy for the conversion of glucose to ATP. A reduced capacity for energy conversion could have significant implications for vulnerability to cardiovascular disease in adults who are born LBW. © 2013 Elsevier Inc.

DOI10.1016/j.metabol.2013.06.013
CitationsScopus - 2
2013Lie S, Morrison JL, Williams-Wyss O, Ozanne SE, Zhang S, Walker SK, et al., 'Impact of embryo number and periconceptional undernutrition on factors regulating adipogenesis, lipogenesis, and metabolism in adipose tissue in the sheep fetus', AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 305 E931-E941 (2013) [C1]
DOI10.1152/ajpendo.00180.2013Author URL
CitationsScopus - 3Web of Science - 1
2013Lock M, McGillick EV, Orgeig S, McMillen IC, Morrison JL, 'Regulation of fetal lung development in response to maternal overnutrition', CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 40 803-816 (2013) [C1]
DOI10.1111/1440-1681.12166Author URL
CitationsScopus - 1
2013Zhang S, Morrison JL, Gill A, Rattanatray L, MacLaughlin SM, Kleemann D, et al., 'Dietary restriction in the periconceptional period in normal-weight or obese ewes results in increased abundance of angiotensin-converting enzyme (ACE) and angiotensin type 1 receptor (AT1R) in the absence of changes in ACE or AT1R methylation in the adrenal of the offspring', REPRODUCTION, 146 443-454 (2013) [C1]
DOI10.1530/REP-13-0219Author URL
2013Lie S, Sim SM, McMillen IC, Williams-Wyss O, MacLaughlin SM, Kleemann DO, et al., 'Maternal undernutrition around the time of conception and embryo number each impact on the abundance of key regulators of cardiac growth and metabolism in the fetal sheep heart', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 4 377-390 (2013) [C1]
DOI10.1017/S2040174413000354Author URL
CitationsScopus - 3Web of Science - 3
2013Zhang S, Williams-Wyss O, MacLaughlin SM, Walker SK, Kleemann DO, Suter CM, et al., 'Maternal undernutrition during the first week after conception results in decreased expression of glucocorticoid receptor mRNA in the absence of GR exon 1(7) hypermethylation in the fetal pituitary in late gestation', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 4 391-401 (2013) [C1]
DOI10.1017/S2040174413000378Author URL
CitationsScopus - 3Web of Science - 3
2013Lie S, Duffield JA, McMillen IC, Morrison JL, Ozanne SE, Pilgrim C, Muhlhausler BS, 'The effect of placental restriction on insulin signaling and lipogenic pathways in omental adipose tissue in the postnatal lamb', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 4 421-429 (2013) [C1]
DOI10.1017/S2040174413000202Author URL
CitationsScopus - 2Web of Science - 2
2012Botting KJ, Wang KCW, Padhee M, McMillen IC, Summers-Pearce B, Rattanatray L, et al., 'Early origins of heart disease: Low birth weight and determinants of cardiomyocyte endowment', CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 39 814-823 (2012) [C3]
DOI10.1111/j.1440-1681.2011.05649.xAuthor URL
CitationsScopus - 12Web of Science - 11
2012Wang KCW, Botting KJ, Padhee M, Zhang S, McMillen IC, Suter CM, et al., 'Early origins of heart disease: Low birth weight and the role of the insulin-like growth factor system in cardiac hypertrophy', CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 39 958-964 (2012) [C3]
DOI10.1111/j.1440-1681.2012.05743.xAuthor URL
CitationsScopus - 1Web of Science - 1
2012Morrison JL, Botting KJ, Soo PS, McGillick EV, Hiscock J, Zhang S, et al., 'Antenatal steroids and the IUGR fetus: Are exposure and physiological effects on the lung and cardiovascular system the same as in normally grown fetuses?', Journal of Pregnancy, 2012 (2012) [C3]

Glucocorticoids are administered to pregnant women at risk of preterm labour to promote fetal lung surfactant maturation. Intrauterine growth restriction (IUGR) is associated with an increased risk of preterm labour. Hence, IUGR babies may be exposed to antenatal glucocorticoids. The ability of the placenta or blood brain barrier to remove glucocorticoids from the fetal compartment or the brain is compromised in the IUGR fetus, which may have implications for lung, brain, and heart development. There is conflicting evidence on the effect of exogenous glucocorticoids on surfactant protein expression in different animal models of IUGR. Furthermore, the IUGR fetus undergoes significant cardiovascular adaptations, including altered blood pressure regulation, which is in conflict with glucocorticoid-induced alterations in blood pressure and flow. Hence, antenatal glucocorticoid therapy in the IUGR fetus may compromise regulation of cardiovascular development. The role of cortisol in cardiomyocyte development is not clear with conflicting evidence in different species and models of IUGR. Further studies are required to study the effects of antenatal glucocorticoids on lung, brain, and heart development in the IUGR fetus. Of specific interest are the aetiology of IUGR and the resultant degree, duration, and severity of hypoxemia. © 2012 Janna L. Morrison et al.

DOI10.1155/2012/839656
CitationsScopus - 9
2011Zhang S, Rattanatray L, Morrison JL, Nicholas LM, Lie S, McMillen IC, 'Maternal Obesity and the Early Origins of Childhood Obesity: Weighing Up the Benefits and Costs of Maternal Weight Loss in the Periconceptional Period for the Offspring', EXPERIMENTAL DIABETES RESEARCH, (2011) [C3]
DOI10.1155/2011/585749Author URL
CitationsScopus - 18Web of Science - 11
2011Wang KCW, Zhang L, McMillen IC, Botting KJ, Duffield JA, Zhang S, et al., 'Fetal growth restriction and the programming of heart growth and cardiac insulin-like growth factor 2 expression in the lamb', The Journal of Physiology, 589 4709-4722 (2011) [C1]
DOI10.1113/jphysiol.2011.211185
CitationsScopus - 20Web of Science - 17
2011Micke GC, Sullivan TM, McMillen IC, Gentili S, Perry VEA, 'Heifer nutrient intake during early- and mid-gestation programs adult offspring adiposity and mRNA expression of growth-related genes in adipose depots', Reproduction, 141 697-706 (2011) [C1]
DOI10.1530/REP-10-0332
CitationsScopus - 9Web of Science - 9
2011Zhang S, Rattanatray L, McMillen IC, Suter CM, Morrison JL, 'Periconceptional nutrition and the early programming of a life of obesity or adversity', Progress in Biophysics and Molecular Biology, 106 307-314 (2011) [C1]
DOI10.1016/j.pbiomolbio.2010.12.004
CitationsScopus - 20Web of Science - 20
2011Micke GC, Sullivan TM, McMillen IC, Gentili S, Perry VEA, 'Protein intake during gestation affects postnatal bovine skeletal muscle growth and relative expression of IGF1, IGF1R, IGF2 and IGF2R', Molecular and Cellular Endocrinology, 332 234-241 (2011) [C1]
DOI10.1016/j.mce.2010.10.018
CitationsScopus - 14Web of Science - 14
2011Bazargan M, Davey AK, Muhlhausler BS, Morrison JL, McMillen IC, Foster DJR, 'Simple HPLC method for determination of rosiglitazone in sheep plasma and amniotic fluid and its application in a pregnant sheep model', Journal of Pharmaceutical and Biomedical Analysis, 55 360-365 (2011) [C1]
DOI10.1016/j.jpba.2011.01.026
CitationsScopus - 5Web of Science - 6
2010Rattanatray L, MacLaughlin SM, Kleemann DO, Walker SK, Muhlhausler BS, McMillen IC, 'Impact of maternal periconceptional overnutrition on fat mass and expression of adipogenic and lipogenic genes in visceral and subcutaneous fat depots in the postnatal lamb', Endocrinology, 151 5195-5205 (2010) [C1]
DOI10.1210/en.2010-0501
CitationsScopus - 32Web of Science - 32
2010Tosh DN, Fu Q, Callaway CW, McKnight RA, McMillen IC, Ross MG, et al., 'Epigenetics of programmed obesity: Alteration in IUGR rat hepatic IGF1 mRNA expression and histone structure in rapid vs. delayed postnatal catch-up growth', American Journal of Physiology: Gastrointestinal and Liver Physiology, 299 1023-1029 (2010) [C1]
DOI10.1152/ajpgi.00052.2010
CitationsScopus - 34Web of Science - 31
2010MacLaughlin SM, Walker SK, Kleemann DO, Tosh DN, McMillen IC, 'Periconceptional undernutrition and being a twin each alter kidney development in the sheep fetus during early gestation', American Journal of Physiology: Regulatory Integrative and Comparative Physiology, 298 692-699 (2010) [C1]
DOI10.1152/ajpregu.00495.2009
CitationsScopus - 9Web of Science - 9
2010Zhang S, Rattanatray L, MacLaughlin SM, Cropley JE, Suter CM, Molloy L, et al., 'Periconceptional undernutrition in normal and overweight ewes leads to increased adrenal growth and epigenetic changes in adrenal IGF2/H19 gene in offspring', The FASEB Journal, 24 2772-2782 (2010) [C1]
DOI10.1096/fj.09-154294
CitationsScopus - 42Web of Science - 39
2010Morrison JL, Duffield JA, Muhlhausler BS, Gentili S, McMillen IC, 'Fetal growth restriction, catch-up growth and the early origins of insulin resistance and visceral obesity', Pediatric Nephrology, 25 669-677 (2010) [C1]
DOI10.1007/s00467-009-1407-3
CitationsScopus - 66Web of Science - 61
2010Orgeig S, Crittenden TA, Marchant C, McMillen IC, Morrison JL, 'Intrauterine growth restriction delays surfactant protein maturation in the sheep fetus', American Journal of Physiology: Lung Cellular and Molecular Physiology, 298 575-583 (2010) [C1]
DOI10.1152/ajplung.00226.2009
CitationsScopus - 24Web of Science - 16
2009Gentili S, Morrison JL, McMillen IC, 'Intrauterine growth restriction and differential patterns of hepatic growth and expression of IGF1, PCK2, and HSDL1 mRNA in the sheep fetus in late gestation', Biology of Reproduction, 80 1121-1127 (2009) [C1]
DOI10.1095/biolreprod.108.073569
CitationsScopus - 22Web of Science - 22
2009Muhlhausler BS, Morrison JL, McMillen IC, 'Rosiglitazone increases the expression of peroxisome proliferator-activated receptor-y target genes in adipose tissue, liver, and skeletal muscle in the sheep fetus in late gestation', Endocrinology, 150 4287-4294 (2009) [C1]
DOI10.1210/en.2009-0462
CitationsScopus - 19Web of Science - 16
2009Muhlhausler BS, Duffield JA, Ozanne SE, Pilgrim C, Turner N, Morrison JL, McMillen IC, 'The transition from fetal growth restriction to accelerated postnatal growth: A potential role for insulin signalling in skeletal muscle', The Journal of Physiology, 587 4199-4211 (2009) [C1]
DOI10.1113/jphysiol.2009.173161
CitationsScopus - 40Web of Science - 35
2009Duffield JA, Vuocolo T, Tellam R, McFarlane JR, Kauter KG, McMillen IC, Muhlhausler BS, 'Intrauterine growth restriction and the sex specific programming of leptin and peroxisome proliferator-activated receptor y (PPARy) mRNA expression in visceral fat in the lamb', Pediatric Research, 66 59-65 (2009) [C1]
DOI10.1203/PDR.0b013e3181a7c121
CitationsScopus - 19Web of Science - 17
2009Dyer JL, McMillen IC, Warnes KE, Morrison JL, 'No Evidence for an Enhanced Role of Endothelial Nitric Oxide in the Maintenance of Arterial Blood Pressure in the IUGR Sheep Fetus', Placenta, 30 705-710 (2009) [C1]
DOI10.1016/j.placenta.2009.05.003
CitationsScopus - 8Web of Science - 6
2008Muhlhausler BS, Adams CL, McMillen IC, 'Maternal nutrition and the programming of obesity: The brain', Organogenesis, 4 144-152 (2008) [C1]
DOI10.4161/org.4.3.6503
CitationsScopus - 22
2008Szarek E, Farrand K, McMillen IC, Young IR, Houghton D, Schwartz J, 'Hypothalamic input is required for development of normal numbers of thyrotrophs and gonadotrophs, but not other anterior pituitary cells in late gestation sheep', The Journal of Physiology, 586 1185-1194 (2008) [C1]
DOI10.1113/jphysiol.2007.141523
CitationsScopus - 8Web of Science - 5
2008Philp LK, Muhlhausler BS, Janovska A, Wittert GA, Duffield JA, McMillen IC, 'Maternal overnutrition suppresses the phosphorylation of 5'-AMP-activated protein kinase in liver, but not skeletal muscle, in the fetal and neonatal sheep', American Journal of Physiology: Regulatory Integrative and Comparative Physiology, 295 1982-1990 (2008) [C1]
DOI10.1152/ajpregu.90492.2008
CitationsScopus - 11Web of Science - 10
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DOI10.1016/j.domaniend.2008.01.007
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2008McMillen IC, MacLaughlin SM, Muhlhausler BS, Gentili S, Duffield JL, Morrison JL, 'Developmental origins of adult health and disease: The role of periconceptional and foetal nutrition', Basic and Clinical Pharmacology and Toxicology, 102 82-89 (2008) [C1]
DOI10.1111/j.1742-7843.2007.00188.x
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2007Morrison JL, Botting KJ, Dyer JL, Williams SJ, Thornburg KL, McMillen IC, 'Restriction of placental function alters heart development in the sheep fetus', AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 293 R306-R313 (2007) [C1]
DOI10.1152/ajpregu.00798.2006Author URL
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2007Lie S, Muhlhausler BS, Duffield JA, Morrison JL, McMillen IC, 'The effect of birthweight and gender on the expression of AMP-activated kinase (AMPK) in omental adipose tissue in the postnatal lamb', EARLY HUMAN DEVELOPMENT, 83 S49-S49 (2007)
DOI10.1016/S0378-3782(07)70060-9Author URL
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2007Tosh DN, Lane RH, Callaway CW, McKnight RA, McMillen IC, Ross MG, Desai M, 'Maternal food restriction during pregnancy affects hepatic IGF-1 mRNA and chromatin structure in the adult IUGR offspring', EARLY HUMAN DEVELOPMENT, 83 S55-S55 (2007)
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2007Wyss O, MacLaughlin SM, Walker SK, McMillen IC, 'Impact of in vitro embryo culture on fetal adrenal growth and steroidogenic gene expression in the sheep in late gestation', EARLY HUMAN DEVELOPMENT, 83 S76-S76 (2007)
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2007Botting KJ, Gentilli S, McMillen IC, Morrison JL, 'Chronic fetal hypoxia induces HIF1 alpha expression in the sheep fetal heart', EARLY HUMAN DEVELOPMENT, 83 S88-S88 (2007)
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2007Snell AD, McMillen IC, Gentili S, Morrison JL, 'Placental restriction leads to an upregulation of the angiotensin II receptors AT(1)R and AT(2)R mRNA in the aorta of the fetal sheep in late gestation', EARLY HUMAN DEVELOPMENT, 83 S94-S94 (2007)
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2007MacLauglin SM, McMillen IC, 'Impact of periconceptional undernutrition (PCUN) and embryo number on the development of the renin angiotensin (RAS) system in the fetal sheep kidney during early gestation', EARLY HUMAN DEVELOPMENT, 83 S106-S106 (2007)
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2007Gentili S, Morrison JL, McMillen IC, 'The effect of chronic hypoxia on liver growth and HIF1 alpha, IGF1, GLUT1 and G3PDH mRNA expression in the late gestation fetal sheep', EARLY HUMAN DEVELOPMENT, 83 S166-S166 (2007)
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2005Danielson L, McMillen IC, Dyer JL, Morrison JL, 'Restriction of placental growth results in greater hypotensive response to alpha-adrenergic blockade in fetal sheep during late gestation', JOURNAL OF PHYSIOLOGY-LONDON, 563 611-620 (2005) [C1]
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2005Williams SJ, Campbell ME, McMillen IC, Davidge ST, 'Differential effects of maternal hypoxia or nutrient restriction on carotid and femoral vascular function in neonatal rats', AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 288 R360-R367 (2005) [C1]
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2005McMillen IC, Robinson JS, 'Developmental origins of the metabolic syndrome: Prediction, plasticity, and programming', PHYSIOLOGICAL REVIEWS, 85 571-633 (2005) [C1]
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2004Keating DJ, Rychkov GY, Adams MB, Holgert H, McMillen IC, Roberts ML, 'Opioid receptor stimulation suppresses the adrenal medulla hypoxic response in sheep by actions on Ca2+ and K+ channels', JOURNAL OF PHYSIOLOGY-LONDON, 555 489-502 (2004) [C1]
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DOI10.1203/01.PDR.0000113786.35966.2CAuthor URL
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2004Morrison JL, Riggs KW, Chien C, Gruber N, McMillen IC, Rurak DW, 'Chronic maternal fluoxetine infusion in pregnant sheep: effects on the maternal and fetal hypothalamic-pituitary-adrenal axes', PEDIATRIC RESEARCH, 56 40-46 (2004) [C1]
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2004Gatford KL, De Blasio MJ, Thavaneswaran P, Robinson JS, McMillen IC, Owens JA, 'Postnatal ontogeny of glucose homeostasis and insulin action in sheep', AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 286 E1050-E1059 (2004) [C1]
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2004Warnes KE, McMillen IC, Robinson JS, Coulter CL, 'Metyrapone infusion stimulates adrenal growth without activating the cell cycle or the IGF system in the late gestation fetal sheep', ENDOCRINE RESEARCH, 30 535-539 (2004) [C1]
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2004McMillen IC, Schwartz J, Coulter CL, Edwards LJ, 'Early embryonic environment, the fetal pituitary-adrenal axis and the timing of parturition', ENDOCRINE RESEARCH, 30 845-850 (2004) [C1]
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2004Muhlhausler BS, McMillen IC, Rouzaud G, Findlay PA, Marrocco EM, Rhind SM, Adam CL, 'Appetite regulatory neuropeptides are expressed in the sheep hypothalamus before birth', JOURNAL OF NEUROENDOCRINOLOGY, 16 502-507 (2004) [C1]
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2003Muhlhausler BS, Roberts CT, Yuen BSJ, Marrocco E, Budge H, Symonds ME, et al., 'Determinants of fetal leptin synthesis, fat mass, and circulating leptin concentrations in well-nourished ewes in late pregnancy', ENDOCRINOLOGY, 144 4947-4954 (2003) [C1]
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2003Warnes KE, Coulter CL, Robinson JS, McMillen IC, 'The effect of intrafetal infusion of metyrapone on arterial blood pressure and on the arterial blood pressure response to angiotensin II in the sheep fetus during late gestation', JOURNAL OF PHYSIOLOGY-LONDON, 552 621-633 (2003) [C1]
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2003Coulter CL, Salkeld MD, McMillen IC, 'Adrenal TGF beta 1 mRNA levels fall during late gestation and are not regulated by cortisol in the sheep fetus', MOLECULAR AND CELLULAR ENDOCRINOLOGY, 206 85-91 (2003) [C1]
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2003Yuen BSJ, Owens PC, Muhlhausler BS, Roberts CT, Symonds ME, Keisler DH, et al., 'Leptin alters the structural and functional characteristics of adipose tissue before birth', FASEB JOURNAL, 17 1102-+ (2003) [C1]
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2002Edwards L, Peura T, Hartwich K, Rudiger S, McMillen IC, Walker S, 'Postnatal growth and circulating ACTH and cortisol concentrations during the first month of life in cloned lambs', ENDOCRINOLOGY, 143 3699-3702 (2002) [C1]
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2002Butler TG, Schwartz J, McMillen IC, 'Differential effects of the early and late intrauterine environment on corticotrophic cell development', JOURNAL OF CLINICAL INVESTIGATION, 110 783-791 (2002) [C1]
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2002Gatford KL, Clarke IJ, De Blasio MJ, McMillen IC, Robinson JS, Owens JA, 'Perinatal growth and plasma GH profiles in adolescent and adult sheep', JOURNAL OF ENDOCRINOLOGY, 173 151-159 (2002) [C1]
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2002Williams SJ, McMillen IC, Zaragoza DB, Olson DM, 'Placental restriction increases the expression of prostaglandin endoperoxide G/H synthase-2 and EP(2) mRNA in the fetal sheep kidney during late gestation', PEDIATRIC RESEARCH, 52 879-885 (2002) [C1]
DOI10.1203/01.PDR.0000036624.37481.7AAuthor URL
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2002Edwards LJ, Bryce AE, Coulter CL, McMillen IC, 'Maternal undernutrition throughout pregnancy increases adrenocorticotrophin receptor and steroidogenic acute regulatory protein gene expression in the adrenal gland of twin fetal sheep during late gestation', MOLECULAR AND CELLULAR ENDOCRINOLOGY, 196 1-10 (2002) [C1]
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2002Coulter CL, Ross JT, Owens JA, Bennett HPJ, McMillen IC, 'Role of pituitary POMC-peptides and insulin-like growth factor II in the developmental biology of the adrenal gland', Archives of Physiology and Biochemistry, 110 99-105 (2002) [C1]

During fetal life, it is critical that there is coordinate regulation of the growth, zonation and differentiation of the fetal adrenal cortex to ensure that cells in key tissues and organs are exposed in a programmed temporal sequence to the actions of glucocorticoids. Glucocorticoids are essential for maturation of key target organs before birth, including the lung, brain, liver, gut, kidney and adrenal, and the prepartum increase in glucocorticoid synthesis and secretion by the fetal adrenal gland is critical for the successful transition to post-natal life. It is also evident that premature or abnormal exposure of embryonic or fetal tissues to glucocorticoids during critical windows of development can irreversibly alter the programmed development of organ systems. Premature or abnormal exposure of the fetus to excess glucocorticoids may occur either as a consequence of endogenous stimulation of the fetal hypothalamo-pituitary-adrenal axis (HPAA) or as a consequence of exposure to exogenous glucocorticoids in a therapeutic context. Administration of synthetic glucocorticoids to women at risk of preterm labour, for example, is a routine clinical practice designed to improve respiratory function and neonatal outcome. It is clearly important to understand what endogenous factors regulate the growth and functional maturation of the adrenal cortex during development and the consequent likelihood of exposure of developing tissues to excess corticosteroids. To date, investigations have centred on the role of ACTH 1-39 in the stimulation of adrenal growth and steroidogenesis in long gestation species, such as the primate and sheep, where maturation and differentiation of organ systems occurs predominantly before birth. In this review, we will focus on the evidence that in addition to ACTH 1-39, other pro-opio-melanocortin (POMC) derived peptides, which are synthesized, processed and secreted by the fetal pituitary, play a role in the coordinate regulation of the specific phases of growth and functional development of the fetal adrenal gland in vivo. We will discuss our recent findings on the direct in vivo actions of N-POMC 1-77 and separately, insulin like growth factor II (IGF-II), as adrenal growth factors. These studies provide an understanding of the separate regulatory mechanisms which control activation of adrenal growth and stimulation of adrenal steroidogenesis in the late gestation fetus.

DOI10.1076/apab.110.1.99.894
CitationsScopus - 21
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2002Buckley P, Schwartz J, Roberts M, McMillen IC, 'Problem based learning increases student confidence in formulating experimental design', FASEB JOURNAL, 16 A753-A753 (2002)
Author URL
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DOI10.1111/j.1469-7793.2001.0561a.xAuthor URL
CitationsScopus - 83Web of Science - 76
2001McMillen IC, Houghton DC, Phillips ID, 'Maturation of cytokine receptors in preparation for birth', BIOCHEMICAL SOCIETY TRANSACTIONS, 29 63-68 (2001) [E1]
Author URL
CitationsScopus - 5Web of Science - 3
2001Adams MB, Brown RE, Gibson C, Coulter CL, McMillen IC, 'Tyrosine hydroxylase protein content in the medulla oblongata of the foetal sheep brain increases in response to acute but not chronic hypoxia', NEUROSCIENCE LETTERS, 316 63-66 (2001) [C1]
DOI10.1016/S0304-3940(01)02381-3Author URL
CitationsScopus - 6Web of Science - 6
2001Phillips ID, Anthony RV, Simonetta G, Owens JA, Robinson JS, McMillen IC, 'Restriction of fetal growth has a differential impact on fetal prolactin and prolactin receptor mRNA expression', JOURNAL OF NEUROENDOCRINOLOGY, 13 175-181 (2001) [C1]
DOI10.1046/j.1365-2826.2001.00608.xAuthor URL
CitationsScopus - 17Web of Science - 13
2001Hudson JN, Buckley P, McMillen IC, 'Linking cardiovascular theory to practice in an undergraduate medical curriculum', ADVANCES IN PHYSIOLOGY EDUCATION, 25 193-201 (2001) [C1]
Author URL
CitationsScopus - 7Web of Science - 5
Co-authorsNicky Hudson
2001Symonds ME, Budge H, Stephenson T, McMillen IC, 'Fetal endocrinology and development - manipulation and adaptation to long-term nutritional and environmental challenges', REPRODUCTION, 121 853-862 (2001) [C1]
Author URL
CitationsScopus - 45Web of Science - 38
2001McMillen IC, Adams MB, Ross JT, Coulter CL, Simonetta G, Owens JA, et al., 'Fetal growth restriction: adaptations and consequences', REPRODUCTION, 122 195-204 (2001) [C1]
DOI10.1530/rep.0.1220195Author URL
CitationsScopus - 132Web of Science - 124
2000Ross JT, McMillen IC, Adams MB, Coulter CL, 'A premature increase in circulating cortisol suppresses expression of 11 beta hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid in the adrenal of the fetal sheep', BIOLOGY OF REPRODUCTION, 62 1297-1302 (2000) [C1]
DOI10.1095/biolreprod62.5.1297Author URL
CitationsScopus - 8Web of Science - 8
2000McMillen IC, Warnes KE, Adams MB, Robinson JS, Owens JA, Coulter CL, 'Impact of restriction of placental and fetal growth on expression of 11 beta-hydroxysteroid dehydrogenase type 1 and type 2 messenger ribonucleic acid in the liver, kidney, and adrenal of the sheep fetus', ENDOCRINOLOGY, 141 539-543 (2000) [C1]
DOI10.1210/en.141.2.539Author URL
CitationsScopus - 32Web of Science - 29
2000Ross JT, Bennett HPJ, James S, McMillen IC, 'Infusion of N-proopiomelanocortin-(1-77) increases adrenal weight and messenger ribonucleic acid levels of cytochrome P-450 17 alpha-hydroxylase in the sheep fetus during late gestation', ENDOCRINOLOGY, 141 2153-2158 (2000) [C1]
DOI10.1210/en.141.6.2153Author URL
CitationsScopus - 19Web of Science - 18
2000Adams MB, McMillen IC, 'Actions of hypoxia on catecholamine synthetic enzyme mRNA expression before and after development of adrenal innervation in the sheep fetus', JOURNAL OF PHYSIOLOGY-LONDON, 529 519-531 (2000) [C1]
DOI10.1111/j.1469-7793.2000.00519.xAuthor URL
CitationsScopus - 10Web of Science - 9
2000Coulter CL, Ross JT, Salkeld MD, Bennett HPJ, James S, McMillen IC, 'N-proopiomelanocortin (1-77) suppresses expression of steroidogenic acute regulatory protein (StAR) mRNA in the adrenal gland of the fetal sheep.', ENDOCRINE RESEARCH, 26 523-529 (2000)
Author URL
CitationsScopus - 7Web of Science - 5
2000Ross JT, Phillips ID, Simonetta G, Owens JA, Robinson JS, McMillen IC, 'Differential effects of placental restriction on IGF-II, ACTH receptor and steroidogenic enzyme mRNA levels in the foetal sheep adrenal', JOURNAL OF NEUROENDOCRINOLOGY, 12 79-85 (2000) [C1]
Author URL
CitationsScopus - 16Web of Science - 14
2000Zhang DY, Lumbers ER, Simonetta G, Wu JJ, Owens JA, Robinson JS, McMillen IC, 'Effects of placental insufficiency on the ovine fetal renin-angiotensin system', EXPERIMENTAL PHYSIOLOGY, 85 79-84 (2000) [C1]
DOI10.1111/j.1469-445X.2000.01939.xAuthor URL
CitationsScopus - 25Web of Science - 22
2000Rigda RS, McMillen IC, Buckley P, 'Bed sharing patterns in a cohort of Australian infants during the first six months after birth', JOURNAL OF PAEDIATRICS AND CHILD HEALTH, 36 117-121 (2000) [C1]
DOI10.1046/j.1440-1754.2000.00468.xAuthor URL
CitationsScopus - 25Web of Science - 23
1999Phillips ID, Anthony RV, Houghton DC, McMillen IC, 'The regulation of prolactin receptor messenger ribonucleic acid levels in the sheep liver before birth: Relative roles of the fetal hypothalamus, cortisol, and the external photoperiod', ENDOCRINOLOGY, 140 1966-1971 (1999) [C1]
DOI10.1210/en.140.5.1966Author URL
CitationsScopus - 11Web of Science - 11
1999Yuen BSJ, McMillen IC, Symonds ME, Owens PC, Bernard SJ, 'Abundance of leptin mRNA in fetal adipose tissue is related to fetal body weight', JOURNAL OF ENDOCRINOLOGY, 163 R1-R4 (1999) [C1]
Author URL
CitationsScopus - 25Web of Science - 27
1999Yuen BSJ, McMillen IC, Symonds ME, Owens PC, 'Abundance of leptin mRNA in fetal adipose tissue is related to fetal body weight (Vol 163, Pg R1, 1999)', JOURNAL OF ENDOCRINOLOGY, 163 R11-R14 (1999) [C1]
DOI10.1677/joe.0.163R011Author URL
CitationsScopus - 43Web of Science - 45
1999Edwards LJ, Simonetta G, Owens JA, Robinson JS, McMillen IC, 'Restriction of placental and fetal growth in sheep alters fetal blood pressure responses to angiotensin II and captopril', JOURNAL OF PHYSIOLOGY-LONDON, 515 897-904 (1999) [C1]
DOI10.1111/j.1469-7793.1999.897ab.xAuthor URL
CitationsScopus - 79Web of Science - 70
1999Butler TG, Schwartz J, McMillen IC, 'Functional heterogeneity of corticotrophs in the anterior pituitary of the sheep fetus', JOURNAL OF PHYSIOLOGY-LONDON, 516 907-913 (1999) [C1]
DOI10.1111/j.1469-7793.1999.0907u.xAuthor URL
CitationsScopus - 10Web of Science - 9
1999Adams MB, Ross JT, Butler TG, McMillen IC, 'Glucocorticoids decrease phenylethanolamine N-methyltransferase mRNA expression in the immature foetal sheep adrenal', JOURNAL OF NEUROENDOCRINOLOGY, 11 569-575 (1999) [C1]
Author URL
CitationsScopus - 10Web of Science - 10
1998Adams MB, Phillips ID, Simonetta G, McMillen IC, 'Differential effects of increasing gestational age and placental restriction on tyrosine hydroxylase, phenylethanolamine N-methyltransferase, and proenkephalin a mRNA levels in the fetal sheep adrenal', JOURNAL OF NEUROCHEMISTRY, 71 394-401 (1998) [C1]
Author URL
CitationsScopus - 18Web of Science - 17
1998Rychkov GY, Adams MB, McMillen IC, Roberts ML, 'Oxygen-sensing mechanisms are present in the chromaffin cells of the sheep adrenal medulla before birth', JOURNAL OF PHYSIOLOGY-LONDON, 509 887-893 (1998) [C1]
DOI10.1111/j.1469-7793.1998.887bm.xAuthor URL
CitationsScopus - 32Web of Science - 30
1998Coulter CL, McMillen IC, Robinson JS, Owens JA, 'Placental restriction alters adrenal medullary development in the midgestation sheep fetus', PEDIATRIC RESEARCH, 44 656-662 (1998) [C1]
DOI10.1203/00006450-199811000-00007Author URL
CitationsScopus - 11Web of Science - 11
1998Warnes KE, Morris MJ, Symonds ME, Phillips ID, Clarke IJ, Owens JA, McMillen IC, 'Effects of increasing gestation, cortisol and maternal undernutrition on hypothalamic neuropeptide Y expression in the sheep fetus', JOURNAL OF NEUROENDOCRINOLOGY, 10 51-57 (1998) [C1]
DOI10.1046/j.1365-2826.1998.00172.xAuthor URL
CitationsScopus - 56Web of Science - 55
1998Symonds ME, Phillips ID, Anthony RV, Owens JA, McMillen IC, 'Prolactin receptor gene expression and foetal adipose tissue', JOURNAL OF NEUROENDOCRINOLOGY, 10 885-890 (1998) [C1]
Author URL
CitationsScopus - 60Web of Science - 58
1997Houghton DC, Young IR, McMillen IC, 'Photoperiodic history and hypothalamic control of prolactin secretion before birth', Endocrinology, 138 1506-1511 (1997) [C1]
DOI10.1210/en.138.4.1506
CitationsScopus - 10Web of Science - 10
1997Phillips ID, Anthony RV, Butler TG, Ross JT, McMillen IC, 'Hepatic prolactin receptor gene expression increases in the sheep fetus before birth and after cortisol infusion', Endocrinology, 138 1351-1354 (1997) [C1]
DOI10.1210/en.138.3.1351
CitationsScopus - 23Web of Science - 22
1997Simonetta G, Rourke AK, Owens JA, Robinson JS, McMillen IC, 'Impact of placental restriction on the development of the sympathoadrenal system', Pediatric Research, 42 805-811 (1997) [C1]
CitationsScopus - 54Web of Science - 53
1997Ross JT, Phillips ID, Owens JA, McMillen IC, 'Cortisol differentially regulates pituitary-adrenal function in the sheep fetus after disconnection of the hypothalamus and pituitary', Journal of Neuroendocrinology, 9 663-668 (1997) [C1]
CitationsScopus - 12Web of Science - 11
1996Phillips ID, Ross JT, Owens JA, Young IR, McMillen IC, 'The peptide ACTH(1-39), adrenal growth and steroidogenesis in the sheep fetus after disconnection of the hypothalamus and pituitary', The Journal of Physiology, 491 871-879 (1996) [C1]
CitationsScopus - 37Web of Science - 36
1996Phillips ID, Simonetta G, Owens JA, Robinson JS, Clarke IJ, McMillen IC, 'Placental restriction alters the functional development of the pituitary-adrenal axis in the sheep fetus during late gestation', Pediatric Research, 40 861-866 (1996) [C1]
CitationsScopus - 83Web of Science - 74
1996Simonetta G, Young IR, McMillen IC, 'Plasma catecholamine and Met-Enkephalin-Arg6-Phe7 responses to hypoxaemia after adrenalectomy in the fetal sheep', Journal of the Autonomic Nervous System, 60 108-114 (1996) [C1]
DOI10.1016/0165-1838(96)00026-4
CitationsScopus - 6Web of Science - 6
1996Simonetta G, Young IR, McMillen IC, 'The role of the pituitary-thyroid axis in the developmental regulation of enkephalin-containing peptides in the superior cervical ganglia and adrenal of the fetal sheep', Journal of the Autonomic Nervous System, 59 34-40 (1996) [C1]
DOI10.1016/0165-1838(96)00005-7
1996Simonetta G, Young IR, McMillen IC, 'Thyroxine replacement after hypophysectomy alters the pattern of enkephalin localisation in the adrenal medulla of the fetal sheep', Journal of the Autonomic Nervous System, 59 60-65 (1996) [C1]
DOI10.1016/0165-1838(96)00007-0
CitationsScopus - 5Web of Science - 4
1996Adams MB, Simonetta G, McMillen IC, 'The non-neurogenic catecholamine response of the fetal adrenal to hypoxia is dependent on activation of voltage sensitive Ca2+ channels', Developmental Brain Research, 94 182-189 (1996) [C1]
CitationsScopus - 20Web of Science - 20
1996Phillips ID, Fielke SL, Young IR, McMillen IC, 'The relative roles of the hypothalamus and cortisol in the control of prolactin gene expression in the anterior pituitary of the sheep fetus', Journal of Neuroendocrinology, 8 929-933 (1996) [C1]
CitationsScopus - 12Web of Science - 10
1995McMillen IC, Houghton DC, Young IR, 'Melatonin and the development of circadian and seasonal rhythmicity.', Reproduction: Supplement, 49 137-146 (1995) [C1]
CitationsScopus - 18
1995Butler TG, Simonetta G, Roberts ML, McMillen IC, 'Impact of gestational age on the catecholamine responses of the fetal sheep adrenal to cholinergic stimulation in vitro', Experimental Physiology, 80 767-777 (1995) [C1]
CitationsScopus - 5Web of Science - 5
1995Houghton DC, Young IR, McMillen IC, 'Evidence for hypothalamic control of the diurnal rhythms in prolactin and melatonin in the fetal sheep during late gestation', Endocrinology, 136 218-223 (1995)
CitationsScopus - 19Web of Science - 19
1995McMillen IC, Merei JJ, White A, Crosby S, Schwartz J, 'Increasing gestational age and cortisol alter the ratio of ACTH precursors:ACTH secreted from the anterior pituitary of the fetal sheep', The Journal of Physiology, 144 569-576 (1995) [C1]
CitationsScopus - 23Web of Science - 18
1995Houghton DC, Young IR, McMillen IC, 'Response of prolactin to different photoperiods after surgical disconnection of the hypothalamus and pituitary in sheep fetuses', Reproduction, 104 199-206 (1995) [C1]
CitationsScopus - 18Web of Science - 17
1994Simonetta G, Young IR, McMillen IC, 'Thyroid hormone replacement restores circulating enkephalin concentrations in hypophysectomized fetal sheep', Journal of Neurochemistry, 63 1386-1391 (1994) [C1]
CitationsScopus - 2Web of Science - 2
1994Fielke SL, Young IR, Walker DW, McMillen IC, 'Effect of two weeks of continuous light on the development of the circadian melatonin rhythm in newborn lambs.', Journal of Pineal Research, 17 118-122 (1994) [C1]
CitationsScopus - 3Web of Science - 1
1993Merei JJ, Rao A, Clarke IJ, McMillen IC, 'Proopiomelanocortin, prolactin and growth hormone messenger ribonucleic acid levels in the fetal sheep pituitary during late gestation', Acta Endocrinologica, 129 263-267 (1993) [C1]
CitationsScopus - 15Web of Science - 19
1993COULTER CL, YOUNG IR, SIMONETTA G, MCMILLEN IC, 'EFFECT OF HYPOPHYSECTOMY ON PLASMA-CATECHOLAMINES AND ENKEPHALINS IN FETAL SHEEP', AMERICAN JOURNAL OF PHYSIOLOGY, 265 E203-E209 (1993)
Author URL
CitationsWeb of Science - 7
1993Coulter CL, Young IR, Simonetta G, McMillen IC, 'Effect of hypophysectomy on plasma catecholamines and enkephalins in fetal sheep.', The American journal of physiology, 265 E203-E209 (1993)
1993Houghton DC, Walker DW, Young IR, McMillen IC, 'Melatonin and the light-dark cycle separately influence daily behavioral and hormonal rhythms in the pregnant ewe and sheep fetus', Endocrinology, 133 90-98 (1993) [C1]
DOI10.1210/en.133.1.90
CitationsScopus - 17Web of Science - 22
1993Simonetta G, Young IR, Coulter CL, Hey NJ, McMillen IC, 'Fetal adrenalectomy does not affect circulating enkephalins in the sheep fetus during late gestation', Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships, 57 408-415 (1993) [C1]
CitationsScopus - 12Web of Science - 15
1993McMillen IC, Merei JJ, 'Effect of gestational age, CRF and cortisol on ACTH secretion from slices of fetal sheep pituitaries in an in vitro perifusion system', Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships, 58 564-569 (1993) [C1]
CitationsWeb of Science - 2
1993McMillen IC, Mulvogue HM, Kok JSM, Deayton JM, Nowak R, Adamson TM, 'Circadian rhythms in sleep and wakefulness and in salivary melatonin and cortisol concentrations in mothers of term and preterm infants', Sleep, 16 624-631 (1993) [C1]
CitationsScopus - 7Web of Science - 6
1993Coulter CL, Young IR, Simonetta G, McMillen IC, 'Effect of hypophysectomy on plasma catecholamines and enkephalins in fetal sheep', American Journal of Physiology: Endocrinology and Metabolism, 265 203-209 (1993) [C1]
CitationsScopus - 5
1992Ozolins IZ, Young IR, McMillen IC, 'Surgical disconnection of the hypothalamus from the fetal pituitary abolishes the corticotrophic response to intrauterine hypoglycemia or hypoxemia in the sheep during late gestation', Endocrinology, 130 2438-2445 (1992) [C1]
DOI10.1210/en.130.5.2438
CitationsScopus - 27Web of Science - 29
1992Coulter CL, Young IR, Browne CA, McMillen IC, 'The effect of fetal hypophysectomy with or without ACTH replacement on the molecular weight profile of enkephalin-containing peptides in the adrenal medulla of the fetal sheep', Journal of Endocrinology, 134 369-375 (1992) [C1]
CitationsScopus - 6Web of Science - 8
1992Antolovich GC, McMillen IC, Robinson PM, Silver M, Young IR, Perry RA, 'Effect of cortisol infusion on the pituitary-adrenal axis of the hypothalamo-pituitary-disconnected fetal sheep', Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships, 56 312-319 (1992) [C1]
CitationsScopus - 10Web of Science - 11
1991Ozolins IZ, Antolovich GC, Browne CA, Perry RA, Robinson PM, Silver M, McMillen IC, 'Effect of adrenalectomy or long term cortisol or adrenocorticotropin (ACTH)-releasing factor infusion on the concentration and molecular weight distribution of ACTH in fetal sheep plasma', Endocrinology, 129 1942-1950 (1991) [C1]
CitationsScopus - 18Web of Science - 31
1991McMillen IC, Walker DW, 'Effects of different lighting regimes on daily hormonal and behavioural rhythms in the pregnant ewe and sheep fetus', The Journal of Physiology, 442 465-476 (1991) [C1]
CitationsScopus - 7Web of Science - 10
1991Anotolovich GC, McMillen IC, Robinson PM, Silver M, Young IR, Perry RA, 'The effect of hypothalamo-pituitary disconnection on the functional and morphologic development of the pituitary-adrenal axis in the fetal sheep in the last third of gestation', Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships, 54 254-261 (1991) [C1]
CitationsScopus - 32Web of Science - 42
1991Coulter CL, Young IR, Browne CA, McMillen IC, 'Different roles of the pituitary and adrenal cortex in the control of enkephalin peptide localization and cortico-medullary interaction in the sheep adrenal during development', Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships, 53 281-286 (1991) [C1]
CitationsScopus - 6Web of Science - 11
1991McMillen IC, Kok JSM, Adamson TM, Deayton JM, Nowak R, 'Development of circadian sleep-wake rhythms in preterm and full-term infants', Pediatric Research, 29 381-384 (1991) [C1]
CitationsScopus - 63Web of Science - 69
1991McMillen IC, Walker DW, Young IR, Nowak R, 'A daily prolactin rhythm persists in the ewe, foetus and newborn lamb after maternal pinealectomy in late gestation', Journal of Neuroendocrinology, 3 369-374 (1991) [C1]
CitationsScopus - 4Web of Science - 11
1991Simonetta G, Walker DW, McMillen IC, 'Effect of feeding on the diurnal rhythm of plasma cortisol and adrenocorticotrophic hormone concentrations in the pregnant ewe and sheep fetus', Experimental Physiology, 76 219-229 (1991) [C1]
CitationsScopus - 22Web of Science - 27
1990DICKSON KA, HOOPER SB, MCMILLEN IC, HARDING R, 'ENDOCRINE AND FLUID-BALANCE RESPONSES TO AMNIOTIC AND ALLANTOIC FLUID LOSS IN SHEEP', AMERICAN JOURNAL OF PHYSIOLOGY, 259 R745-R752 (1990)
Author URL
CitationsWeb of Science - 15
1990Ozolins IZ, Young IR, McMillen IC, 'Effect of cortisol infusion on basal and corticotropin-releasing factor (CRF)-stimulated plasma ACTH concentrations in the sheep fetus after surgical isolation of the pituitary', Endocrinology, 127 1833-1840 (1990) [C1]
CitationsScopus - 22Web of Science - 38
1990Coulter CL, Browne CA, McMillen IC, 'The molecular weight profile of enkephalin-containing peptides in the sheep adrenal gland changes during development', Endocrinology, 127 330-336 (1990) [C1]
CitationsScopus - 10Web of Science - 18
1990Nowak R, Young IR, McMillen IC, 'Emergence of the diurnal rhythm in plasma melatonin concentrations in newborn lambs delivered to intact or pinealectomized ewes', Journal of Endocrinology, 125 97-102 (1990) [C1]
CitationsScopus - 16Web of Science - 22
1990McMillen IC, Antolovich GC, Mercer JE, Perry RA, Silver M, 'Proopiomelanocortin messenger RNA levels are increased in the anterior pituitary of the sheep fetus after adrenalectomy in late gestation', Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships, 52 297-302 (1990) [C1]
CitationsScopus - 24Web of Science - 44
1990Antolovich GC, Clarke IJ, McMillen IC, Perry RA, Robinson PM, Silver M, Young R, 'Hypothalamo-pituitary disconnection in the fetal sheep', Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships, 51 1-9 (1990) [C1]
CitationsScopus - 24Web of Science - 38
1990Jephcott EH, Lynn RD, Thorburn GD, McMillen IC, 'Effects of electroimmobilisation on blood gas and pH status in sheep', Research in Veterinary Science, 48 314-320 (1990) [C1]
CitationsScopus - 1Web of Science - 1
1990Coulter CL, Giraud AS, Hooper SB, Parker L, McMillen IC, 'Fetal asphyxia stimulated an increase in fetal plasma catecholamines and [Met]-enkephalin-arg6-phe7 in the late-gestation sheep fetus', Journal of Developmental Physiology, 14 267-272 (1990) [C2]
CitationsScopus - 7Web of Science - 10
1990Walker DW, Davies AN, McMillen IC, 'Effect of hyperthermia on the plasma concentrations of prolactin and cortisol in the fetal lamb and pregnant ewe during late gestation', Journal of Developmental Physiology, 13 173-177 (1990) [C2]
CitationsScopus - 7Web of Science - 8
1990McMillen IC, Nowak R, Walker DW, Young IR, 'Maternal pinealectomy alters the daily pattern of fetal breathing in sheep', American Journal of Physiology: Regulatory Integrative and Comparative Physiology, 258 284-287 (1990) [C1]
CitationsScopus - 13Web of Science - 17
1990Dickson KA, Hooper SB, McMillen IC, Harding R, 'Endocrine and fluid-balance responses to amniotic and allantoic fluid loss in sheep', American Journal of Physiology: Regulatory Integrative and Comparative Physiology, 259 745-752 (1990) [C1]
CitationsScopus - 9
1990Callea J, McMillen IC, Walker DW, 'Effect of feeding regimen on diurnal variation of breathing movements in late-gestation fetal sheep', Journal of Applied Physiology, 68 1786-1792 (1990) [C1]
CitationsScopus - 3Web of Science - 9
1989McMillen IC, Parkington HC, McCance I, 'Effect of isoprenaline on the output of melatonin from fetal and newborn lamb pineals glands in vitro', Acta Endocrinologica, 121 773-776 (1989) [C1]
CitationsScopus - 4Web of Science - 8
1989Coulter CL, Young IR, Browne CA, McMillen IC, 'Effect of hypophysectomy on the growth and development of the sheep adrenal gland: A morphometric study', Acta Endocrinologica, 120 301-307 (1989) [C1]
CitationsScopus - 6Web of Science - 12
1989Coulter CL, Mulvogue HM, Young IR, Browne CA, McMillen IC, 'Effect of fetal hypophysectomy on the localization of the catecholamine biosynthetic enzymes and enkephalins in the adrenal medulla of the fetal sheep', Journal of Endocrinology, 121 425-430 (1989) [C1]
CitationsScopus - 8Web of Science - 13
1989McMillen IC, Nowak R, 'Maternal pinealectomy abolishes the diurnal rhythm in plasma melatonin concentrations in the fetal sheep and pregnant ewe during late gestation', Journal of Endocrinology, 120 459-464 (1989) [C1]
CitationsScopus - 41Web of Science - 65
1989ANTOLOVICH GC, INGRAM C, MCMILLEN IC, PERRY RA, ROBINSON PM, SILVER M, YOUNG R, 'THE EFFECT OF DISCONNECTION OF THE PITUITARY FROM THE HYPOTHALAMUS IN THE FETAL LAMB UPON ADRENAL-FUNCTION AND GESTATION LENGTH', JOURNAL OF PHYSIOLOGY-LONDON, 417 P152-P152 (1989)
Author URL
CitationsWeb of Science - 3
1989McMillen IC, Jenkin G, Haji-Baba AS, Browne CA, Thorburn GD, 'Effect of y3 or y2 Melanocyte Stimulating Hormone on steroidogenesis in the fetal sheep during late gestation', Life Sciences, 44 563-569 (1989) [C1]
CitationsScopus - 1Web of Science - 1
1989McMillen IC, Deayton JM, 'Effect of morphine and naloxone on plasma prolactin concentrations in the fetal sheep and pregnant ewe during late gstation', Neuroendocrinology: international journal for basic and clinical studies on neuroendocrine relationships, 49 286-290 (1989) [C1]
CitationsScopus - 3Web of Science - 4
1989MCMILLEN IC, NOWAK R, 'THE PRENATAL AND POSTNATAL-DEVELOPMENT OF HORMONAL CIRCADIAN-RHYTHMS', BAILLIERES CLINICAL ENDOCRINOLOGY AND METABOLISM, 3 707-721 (1989)
Author URL
CitationsWeb of Science - 3
1989McMillen IC, Nowak R, 'The pre- and postnatal development of hormonal circadian rhythms', Bailliere's Clinical Endocrinology and Metabolism, 3 707-721 (1989) [C1]
CitationsScopus - 2
1988Zemdegs IZ, McMillen IC, Walker DW, Thorburn GD, Nowak R, 'Diurnal rhythms in plasma melatonin concentrations in the fetal sheep and pregnant ewe during late gestation', Endocrinology, 123 284-289 (1988) [C1]
CitationsScopus - 33Web of Science - 70
1988McMillen IC, Mulvogue HM, Coulter CL, Browne CA, Howe PRC, 'Ontogeny of catecholamine-synthesizing enzymes and enkephalins in the sheep adrenal medulla: An immunocytochemical study', Journal of Endocrinology, 118 221-226 (1988) [C1]
CitationsScopus - 21Web of Science - 38
Co-authorsPeter Howe
1988Jephcott EH, McMillen IC, Congdon P, Thorburn GD, 'Electroimmobilisation and ovine plasma cortisol concentrations: Effect of current intensity, current duration and diazepam', Research in Veterinary Science, 44 21-24 (1988) [C1]
CitationsScopus - 7Web of Science - 13
1988Coulter CL, McMillen IC, Browne CA, 'The catecholamine content of the perinatal rat adrenal gland', General Pharmacology, 19 825-828 (1988) [C1]
CitationsScopus - 8Web of Science - 10
1988McMillen IC, Mercer JE, Thorburn GD, 'Pro-opiomelanocortin mRNA levels fall in the fetal sheep pituitary before birth', Journal of Molecular Endocrinology, 1 141-145 (1988) [C1]
CitationsScopus - 15Web of Science - 33
1987McMillen IC, Thorburn GD, Walker DW, 'Diurnal variations in plasma concentrations of cortisol, prolactin, growth hormone and glucose in the fetal sheep and pregnant ewe during late gestation', Journal of Endocrinology, 114 65-72 (1987) [C1]
CitationsScopus - 34Web of Science - 72
1987Jephcott EH, McMillen IC, Rushen JP, Thorburn GD, 'A comparison of the effects of electroimmobilisation and, or, shearing procedures on ovine plasma concentrations of beta-endorphin/beta-lipoprotein and cortisol', Research in Veterinary Science, 43 97-100 (1987) [C1]
CitationsScopus - 29Web of Science - 43
1987Nowak R, McMillen IC, Redman J, Short RV, 'The correlation between serum and salivary melatonin concentrations and urinary 6-hydroxymelatonin sulphate excretion rates: Two non-invasive techniques for monitoring human circadian rhythmicity', Clinical Endocrinology, 27 445-452 (1987) [C1]
CitationsScopus - 108Web of Science - 107
1987Joseph SA, McMillen IC, Walker DW, 'Effects of naloxone on breathing movements during hypercapnia in the fetal lamb', Journal of Applied Physiology, 62 673-678 (1987) [C1]
CitationsScopus - 2Web of Science - 8
1986Jephcott EH, McMillen IC, Rushen J, Hargreaves A, Thorburn GD, 'Effect of electroimmobilisation on ovine plasma concentrations of beta-endorphin/beta-lipotrophin, cortisol and prolactin', Research in Veterinary Science, 41 371-377 (1986) [C1]
CitationsScopus - 22Web of Science - 32
1986Bocking AD, McMillen IC, Harding R, Thornburn GD, 'Effect of reduced uterine blood flow on fetal and maternal cortisol', Journal of Developmental Physiology, 8 237-245 (1986) [C2]
CitationsScopus - 116Web of Science - 152
1986Mulvogue HM, McMillen IC, Robinson PM, Perry RA, 'Immunocytochemical localization of proyMSH, yMSH, ACTH and ßendorphin/ßlipotrophin in the fetal sheep pituitary; an ontogenetic study', Journal of Developmental Physiology, 8 355-368 (1986) [C1]
CitationsScopus - 20Web of Science - 36
1986McMillen IC, Walker DW, 'Effect of ß-endorphin on fetal breathing movements in sheep', Journal of Applied Physiology, 61 1005-1011 (1986) [C1]
CitationsScopus - 4Web of Science - 7
1985MULVOGUE HW, MCMILLEN IC, ROBINSON PM, PERRY RA, 'IMMUNOHISTOCHEMICAL LOCALIZATION OF PRO-GAMMA-MSH, ACTH AND BETA-ENDORPHIN IN THE ADULT AND FETAL SHEEP PITUITARY', JOURNAL OF ANATOMY, 143 225-226 (1985)
Author URL
1985Perry RA, Mulvogue HM, McMillen IC, Robinson PM, 'Immunohistochemical localization of ACTH in the adult and fetal sheep pituitary', Journal of Developmental Physiology, 7 397-404 (1985) [C2]
CitationsScopus - 25Web of Science - 49
1983McMillen IC, Jenkin G, Robinson JS, Thorburn GD, 'Concentrations of prolactin in the plasma of fetal sheep and in amniotic fluid in late gestation and during dexamethasone-induced parturition', Journal of Endocrinology, 99 107-114 (1983) [C1]
CitationsScopus - 8Web of Science - 19
1983Taylor MJ, McMillen IC, Jenkin G, 'The regulation of ovine placental lactogen: the role of the fetal hypothalamic-pituitary axis', Journal of Developmental Physiology, 5 251-258 (1983) [C2]
CitationsScopus - 2Web of Science - 9
1979GOOD B, BURKE C, COOPER E, KINGSTON EJ, MCMILLEN IC, ROBINSON JS, THORBURN GD, 'DEVELOPMENT OF PITUITARY-THYROID FUNCTION IN THE SHEEP FETUS IN LATE GESTATION', ACTA ENDOCRINOLOGICA, 91 31-31 (1979)
Author URL
1979McMillen IC, Cookson I, Thorburn GD, Robinson JS, 'Lack of effect of morphine and naloxone on plasma concentrations of prolactin and growth hormone in fetal and adult sheep', Acta Endocrinologica - Supplement, 91 78-78 (1979) [C3]
CitationsScopus - 2Web of Science - 3
1979Parry DM, McMillen IC, Robinson JS, Thorburn GD, 'Immunocytochemical localisation of prolactin and growth hormone in the perinatal sheep pituitary. A morphological and quantitative study', Cell and Tissue Research, 197 501-514 (1979) [C1]
CitationsScopus - 1Web of Science - 11
1978McMillen IC, Jenkin G, Thorburn GD, Robinson JS, 'Effect of somatostatin on the concentration of growth hormone in the plasma of foetal sheep', Journal of Endocrinology, 78 453-454 (1978) [C1]
CitationsScopus - 1Web of Science - 10
1978Parry DM, McMillen IC, Willcox DL, 'Immunocytochemical localisation of prolactin and growth hormone in the ovine pituitary. A morphological and quantitative study', Cell and Tissue Research, 194 327-336 (1978) [C1]
CitationsScopus - 3Web of Science - 16
1977McMillen IC, Jenkin G, Robinson JS, 'Prolactin concentrations in foetal and neonatal sheep: effect of thyrotrophin releasing hormone, hypoxia and chlorpromazine', Journal of Endocrinology, 75 54p-55p (1977) [C1]
CitationsScopus - 2Web of Science - 19
Show 217 more journal articles

Review (7 outputs)

YearCitationAltmetricsLink
2006McMillen IC, Edwards LJ, Duffield J, Muhlhausler BS, 'Regulation of leptin synthesis and secretion before birth: implications for the early programming of adult obesity', REPRODUCTION (2006) [D1]
DOI10.1530/rep.1.00303Author URL
CitationsScopus - 57Web of Science - 51
2006MacLaughlin SM, Mühlhäusler BS, Gentili S, McMillen IC, 'When in gestation do nutritional alterations exert their effects? A focus on the early origins of adult disease', Current Opinion in Endocrinology and Diabetes (2006) [D1]

PURPOSE OF REVIEW: Whilst the 'early origins of adult disease' hypothesis has focused primarily on the impact of early undernutrition, an increased fat and energy intake has recently become a dominant characteristic of the human diet. This review presents a summary of recent developments in understanding of how maternal overnutrition and undernutrition during critical windows of development program adult metabolic and cardiovascular disease. RECENT FINDINGS: Recent evidence suggests that exposure to maternal overnutrition results in changes in the development of the energy balance regulating system that may be 'maladaptive' for life and result in an intergenerational cycle of obesity. Whilst activation of the fetal hypothalamo-pituitary-adrenal axis in response to a poor nutritional environment confers an early fitness advantage, it also incurs delayed health costs. Recent findings highlight that such tradeoffs may be anticipated from conception as changes in the periconceptional nutritional environment program the developmental trajectory of the hypothalamo-pituitary- adrenal axis. SUMMARY: A better understanding of the long-term impact of overnutrition in early life and of changes in the nutritional environment of the embryo will provide insights into the timing and type of maternal dietary interventions required to improve metabolic health in adult life. © 2006 Lippincott Williams & Wilkins, Inc.

DOI10.1097/MED.0b013e328010ca30
CitationsScopus - 5
2000Robinson JS, Moore VM, Owens JA, McMillen IC, 'Origins of fetal growth restriction', EUROPEAN JOURNAL OF OBSTETRICS GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2000) [D1]
DOI10.1016/S0301-2115(00)00421-8Author URL
CitationsScopus - 75Web of Science - 62
1997McMillen IC, Simonetta G, Roberts ML, Adams MB, 'Catecholamines, enkephalins and the response of the fetal adrenal medulla to hypoxaemia.', Equine Veterinary Journal. Supplement (1997) [D1]
DOI10.1111/j.2042-3306.1997.tb05081.x
1997Symonds ME, Heasman L, Clarke L, Firth K, Owens JA, McMillen IC, 'Maternal nutrition in late gestation and placental growth', Contemporary Reviews in Obstetrics and Gynaecology (1997) [D1]
CitationsScopus - 4
1995McMillen IC, Phillips ID, Ross JT, Robinson JS, Owens JA, 'Chronic stress--the key to parturition?', Reproduction, Fertility and Development (1995) [D1]
CitationsScopus - 30Web of Science - 29
1986McMillen IC, 'Opioid peptides: A role in Sudden Infant Death Syndrome?', Australian Paediatric Journal (1986) [D2]
CitationsScopus - 4Web of Science - 3
Show 4 more reviews

Conference (71 outputs)

YearCitationAltmetricsLink
2012Wang KCW, Botting KJ, McMillen IC, Thornburg KL, Brooks DA, Morrison JL, 'PATHWAYS FROM BEING SMALL OR PRETERM TO A VULNERABLE HEART', HYPERTENSION, Perth, AUSTRALIA (2012) [E3]
Author URL
2012McMillen IC, Nicholas LM, Rattanatray L, Zhang S, Lei S, Morrison JL, 'Perinatal nutrition and implications for lifelong health lessons from animal model studies', Australasian Medical Journal, Wollongong, Australia (2012) [E3]
2011Lie S, Morrison JL, Wyss O, Zhang S, McMillen CI, 'Periconceptional and Early Preimplantational Undernutrition Alters Gene Expression of Metabolic and Gluconeogenic Regulating Factors in the Liver', REPRODUCTIVE SCIENCES (2011) [E3]
Author URL
2011Wang KCW, Zhang L, McMillen CI, Duffield JA, Zhang S, Suter CM, et al., 'IUGR Results in Increased Cardiac IGF2 mRNA Expression before and after Birth in the Absence of an Increase in Methylation in the Differentially Methylated Region of IGF2/H19', REPRODUCTIVE SCIENCES (2011) [E3]
Author URL
2011Nicholas L, Rattanatray L, Morrison JL, Zhang S, McLaughlin S, Kleeman D, et al., 'Maternal Overnutrition and Weight Loss in the Periconceptional Period Leads to Differential Changes in Hepatic Expression and Epigenetic Modification of IGF2 in the Offspring', REPRODUCTIVE SCIENCES (2011) [E3]
Author URL
2011Zhang S, Wyss O, McMillen IC, Morrison JL, 'Maternal Undernutrition during the Periconceptional Period and Fetal Number Have a Differential Effect on TSH, GH and Prolactin mRNA Expression in the Anterior Pituitary of the Late Gestation Sheep Fetus', REPRODUCTIVE SCIENCES (2011) [E3]
Author URL
2011Poudel R, McMillen CI, Dunn S, Morrison JL, 'IUGR Fetuses Have Increased Adrenal Blood Flow and Decreased Cardiac Blood Flow in the Absence of a Change in Cerebral Blood Flow', REPRODUCTIVE SCIENCES (2011) [E3]
Author URL
2011Gugescheff J, Morrison JL, McMillen CI, Muhlhausler BS, 'Prenatal Activation of PPAR gamma Stimulates NPY Expression in the Fetal Hypothalamus and Promotes Milk Intake in the Lamb', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011) [E3]
Author URL
2011Lie S, Morrison JL, Wyss O, Ozanne SE, Zhang S, McMillen C, 'Periconceptional Undernutrition Alters Insulin Signalling in Muscle from Late Gestation Sheep Fetus', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011) [E3]
Author URL
2011Zhang S, Wyss O, McMillen IC, Morrison JL, 'Maternal Periconceptional Undernutrition and Fetal Number Have Differential Effects on TSH, PRL and GH mRNA Expression in the Anterior Pituitary of the Late Gestation Sheep Fetus', JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE (2011) [E3]
Author URL
2011Poudel R, McMillen IC, Dunn SL, Morrison JL, 'CARDIOVASCULAR RESPONSES TO HYPOVOLEMIA IN THE IUGR FETUS', HYPERTENSION, Melbourne, AUSTRALIA (2011) [E3]
Author URL
2010Nicholas L, Rattanatray L, McLaughlin S, Muhlhausler B, Kleeman D, Walker S, et al., 'Maternal Overnutrition in the Periconceptional Period Results in Altered Expression of Hepatic Metabolic Genes in the Postnatal Lamb', REPRODUCTIVE SCIENCES, Orlando, FL (2010) [E3]
Author URL
2010Zhang S, Wyss O, MacLaughlin SM, Morrison JL, McMillen IC, 'Impact of Maternal Undernutrition during the Periconceptional Period and Fetal Number on Gene Expression in the Fetal Anterior Pituitary during Late Gestation', REPRODUCTIVE SCIENCES, Orlando, FL (2010) [E3]
Author URL
2010Wong AM, McMillen C, Snell A, Morrison JL, 'NGF Gene Expression Is Elevated in the Coronary Artery of Growth Restricted Fetuses and Is Not Related to Endothelin Receptor Expression', REPRODUCTIVE SCIENCES, Orlando, FL (2010) [E3]
Author URL
2010Wang KWC, Zhang L, Brooks DA, Botting KJ, McMillen C, Morrison JL, 'Impact of Intrauterine Growth Restriction on the Insulin-Like Growth Factor System in the Heart of the Fetus and Lamb', REPRODUCTIVE SCIENCES, Orlando, FL (2010) [E3]
Author URL
2010Zhang S, Rattanatray L, MacLaughlin SM, Cropley JE, Suter CM, Molloy L, et al., 'Increased Adrenal Growth and Decreased Methylation of the Adrenal Igf2/H19 Differentially Methylated Region after Exposure to Periconceptional Undernutrition.', REPRODUCTIVE SCIENCES, Orlando, FL (2010) [E3]
Author URL
2010Wong AM, McMillen IC, Snell A, Morrison JL, 'HEART RATE, BUT NOT BLOOD PRESSURE, RESPONSE TO ENDOTHELIN-1 RECEPTOR BLOCKADE IS GREATER IN GROWTH RESTRICTED FETUSES', HYPERTENSION, Sydney, AUSTRALIA (2010) [E3]
Author URL
2010Schwartz J, Sandhu M, Farrand K, Szarek E, McMillen C, Houghton D, et al., 'Effect of surgical isolation of pituitary from hypothalamic influences on corticotroph development in fetal sheep', FASEB JOURNAL (2010) [E3]
Author URL
2009McMillen C, Duffield JA, Muhlhausler BS, Rattanatray L, Gentili S, Morrison JL, 'EARLY PATTERNS OF NUTRITION, GROWTH AND METABOLIC HEALTH', JOURNAL OF PHYSIOLOGICAL SCIENCES (2009) [E3]
Author URL
2009Morrison JL, Botting KJ, McMillen C, 'ROLE OF ANGIOTENSIN RECEPTORS IN CARDIAC HYPERTROPHY INDUCED BY INTRAUTERINE GROWTH RESTRICTION', JOURNAL OF PHYSIOLOGICAL SCIENCES (2009) [E3]
Author URL
2009Morrison JL, Wang KCW, Botting KJ, Brooks DA, McMillen C, 'IMPACT OF INTRAUTERINE GROWTH RESTRICTION ON THE INSULIN-LIKE GROWTH FACTOR SYSTEM IN FETAL SHEEP HEART DEVELOPMENT', JOURNAL OF PHYSIOLOGICAL SCIENCES (2009) [E3]
Author URL
2009Morrison JL, Orgeig S, Crittenden TA, McMillen CI, 'IMPACT OF INTRAUTERINE GROWTH RESTRICTION ON PULMONARY SURFACTANT PROTEIN mRNA EXPRESSION IN THE SHEEP FETUS', JOURNAL OF PHYSIOLOGICAL SCIENCES (2009) [E3]
Author URL
2009Butting KJ, McMillen CI, Gentili S, Morrison JL, 'The Heart's Response to Chronic Hypoxemia in Late Gestation: A Role for HIF-1 alpha', REPRODUCTIVE SCIENCES, Glasgow, SCOTLAND (2009) [E3]
Author URL
2008McMillen IC, Rattanatray L, Bos P, Muhhausler BS, Morrison JL, Gentili S, MacLaughlin SM, 'Nutritional Programming and an Intergenerational Cycle of Obesity', JOURNAL OF NUTRIGENETICS AND NUTRIGENOMICS (2008) [E3]
Author URL
2008Muhlhausler BS, Duffield JA, Morrison JL, McMillen IC, 'Intrauterine growth restriction increases myocellular expression of PGC-1 alpha in male lambs in early postnatal life', REPRODUCTIVE SCIENCES, San Diego, CA (2008) [E3]
Author URL
2008Gentili S, Morrison JL, McMillen IC, 'Maintenance of liver growth in the hypoxic growth restricted fetal sheep: A role for intrahepatic GLUT1?', REPRODUCTIVE SCIENCES, San Diego, CA (2008) [E3]
Author URL
2008Snell AD, McMillen IC, Gentili S, Morrison JL, 'The effect of hypoxia on NGF expression in the aorta and femoral artery in the growth restricted sheep', REPRODUCTIVE SCIENCES, San Diego, CA (2008) [E3]
Author URL
2008Rattanatray L, Muhlhausler BS, McMillen IC, 'Maternal overnutrition does not upregulate hepatic 11 beta HSD1 mRNA expression of the fetal and postnatal lamb.', REPRODUCTIVE SCIENCES, San Diego, CA (2008) [E3]
Author URL
2008Tosh D, Lane RH, Fu Q, Callaway CW, McKnight RA, McMillen IC, et al., 'Delayed postnatal catch-up growth prevents changes in hepatic IGF-1 mRNA and chromatin structure: Epigenetic mechanisms for the prevention of obesity.', REPRODUCTIVE SCIENCES, San Diego, CA (2008) [E3]
Author URL
2008Tosh D, Lane RH, Fu Q, Callaway CW, McKnight RA, McMillen IC, et al., 'Epigenetic mechanisms for diet-induced versus programmed obesity: Effect of high-fat diet on hepatic IGF-1 mRNA and chromatin structure', REPRODUCTIVE SCIENCES, San Diego, CA (2008) [E3]
Author URL
2008Ucinek C, Gentili S, MacLaughlin SM, McMillen IC, 'Effect of gender on adrenal growth and IGF expression in the fetal sheep during late gestation', REPRODUCTIVE SCIENCES, San Diego, CA (2008) [E3]
Author URL
2007MacLaughlin SM, McMillen IC, 'The impact of maternal undernutrition and the presence of multiple embryos during the periconceptional period based on expression of IGFs and GLUTs during early gestation in the sheep', PLACENTA, Kingston, CANADA (2007)
Author URL
2006Schwartz J, Farrand K, McMillen IC, Young IR, Houghton D, Szarek E, 'Effect of hypothalamo-pituitary disconnection on the development of anterior pituitary cells in late gestation ovine fetuses', FASEB JOURNAL, San Francisco, CA (2006)
Author URL
2005Muhlhausler BS, Duffield JA, McMillen IC, 'Maternal overnutrition in late gestation increases peripheral fat deposition in the postnatal lamb', FASEB JOURNAL, San Diego, CA (2005)
Author URL
2005Duffield JA, Tellam R, Vuocolo T, McFarlane JR, Kanter KG, Muhlhausler BS, McMillen IC, 'Impact of low birth weight and gender on PPAR7, leptin and adiponectin expression in the subcutaneous fat of lambs', FASEB JOURNAL, San Diego, CA (2005)
Author URL
2005Williams SJ, McMillen IC, Davidge ST, 'Maternal hypoxia increases constriction to phenylephrine and endothelin-1 in small mesenteric arteries of adult male rat offspring', FASEB JOURNAL, San Diego, CA (2005)
Author URL
2005MacLaughlin SM, Walker SK, McMillen IC, 'Periconceptional undernutrition and fetal brain growth during early gestation in the sheep', FASEB JOURNAL, San Diego, CA (2005)
Author URL
2005Gentili S, Waters MJ, McMillen IC, 'Tissue specific expression of suppressor of cytokine signalling (SOCS)-3 during fetal development', FASEB JOURNAL, San Diego, CA (2005)
Author URL
2005Duffield JA, Vuocolo T, Tellam R, McFarlane JR, Kauter KG, Muhlhausler BS, McMillen IC, 'Differential impact of low birth weight on PPAR gamma and leptin expression in perirenal fat in male and female lambs.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Los Angeles, CA (2005)
Author URL
2005Williams SJ, Hemmings DG, McMillen IC, Davidge ST, 'Maternal hypoxia during late gestation reduces nitric oxide modulation of endothelial-dependent relaxation in mesenteric arteries from seven-month old male rat offspring.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Los Angeles, CA (2005)
Author URL
2005Gentili S, Schwartz J, Waters MJ, McMillen IC, 'The fetal adrenal is a novel prolactin target: Prolactin stimulates expression of suppressor of cytokine signalling-3 (SOCS-3) in the fetal adrenal during late gestation.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Los Angeles, CA (2005)
Author URL
2005MacLaughlin SM, Walker SK, McMillen IC, 'Impact of periconceptional maternal undernutrition on fetal kidney and heart growth during early pregnancy in the sheep.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Los Angeles, CA (2005)
Author URL
2005Tosh DN, Sibbons JP, MacLaughlin SM, Walker SK, McMillen IC, 'Impact of in vitro embryo culture on the expression of insulin like growth factor(IGF)1, IGF2, IGF2R and leptin in adipose tissue in the sheep fetus.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Los Angeles, CA (2005)
Author URL
2005MacLaughlin SM, Walker SK, Roberts CT, Kleemann DO, McMillen IC, 'Periconceptional undernutrition alters the relationship between maternal body weight and fetoplacental growth in the sheep during early gestation.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Los Angeles, CA (2005)
Author URL
2005MacLaughlin SM, Walker SK, McMillen IC, 'Impact of superovulation, artificial insemination, embryo transfer, and in vitro culture on fetoplacental growth in the sheep in late gestation', PEDIATRIC RESEARCH, Toronto, CANADA (2005)
Author URL
2005Williams SJ, Davidge ST, Morrison JL, McMillen IC, 'Chronic hypoxia increases sensitivity to noradrenaline in small mesenteric arteries from fetal sheep in late gestation', PEDIATRIC RESEARCH, Toronto, CANADA (2005)
Author URL
2005Morrison JL, McMillen IC, 'Maintenance of mean arterial blood pressure in chronically hypoxic fetal sheep is not dependent on post ganglionic sympathetic activation', PEDIATRIC RESEARCH, Toronto, CANADA (2005)
Author URL
2005Muhlhausler BS, Adam BL, Findlay PA, Duffield JA, McMillen IC, 'Increased maternal nutrition increases hypothalamic expression of the appetite inhibitor proopiomelanocortin in the postnatal lamb', PEDIATRIC RESEARCH, Toronto, CANADA (2005)
Author URL
2004McMillen IC, Muhlhausler BS, Duffield JA, Yuen BSJ, 'Prenatal programming of postnatal obesity: fetal nutrition and the regulation of leptin synthesis and secretion before birth', PROCEEDINGS OF THE NUTRITION SOCIETY, Brighton, ENGLAND (2004) [E1]
DOI10.1079/PNS2004370Author URL
CitationsScopus - 71Web of Science - 61
2004Edwards LJ, McFarlane JR, Kauter KG, McMillen IC, 'Impact of periconceptional undernutrition in the sheep on maternal and fetal leptin in singleton and twin pregnancies during late gestation.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Houston, TX (2004)
Author URL
2004McMillen IC, Houghton DC, McFarlane J, Kauter KG, Young IR, 'Evidence for hypothalamic control of fetal leptin secretion during late gestation.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Houston, TX (2004)
Author URL
2004Muhlhausler BS, Adam CL, Findlay PA, Marrocco E, McMillen IC, 'Glucose increases the expression of POMC mRNA in the hypothalamus of the fetal sheep in late gestation.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Houston, TX (2004)
Author URL
2004Williams S, Ngo JTV, Campbell ME, McMillen IC, Davidge ST, 'Differential effects of maternal hypoxia and maternal nutrient restriction on carotid and femoral artery function in neonatal rats.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Houston, TX (2004)
Author URL
2004Williams SJ, Hemmings DG, McMillen IC, Davidge ST, 'Maternal hypoxia during late gestation in rats impairs endothelium-dependent relaxation in mesenteric arteries from four month old male offspring.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Houston, TX (2004)
Author URL
2004Gentili S, Waters MJ, McMillen IC, 'Differential expression of SOCS-3 in fetal tissues during late gestation and the regulation of organ growth.', JOURNAL OF THE SOCIETY FOR GYNECOLOGIC INVESTIGATION, Houston, TX (2004)
Author URL
2003Rosenfeld CR, Liu X, Cox BE, McMillen IC, 'Fetal growth restriction (FGR) induces precocious expression of type-1 angiotensin II (ANG II) receptors (AT(1)R) in fetal vascular smooth muscle (VSM)', PEDIATRIC RESEARCH, SEATTLE, WASHINGTON (2003)
Author URL
2003Warnes KE, Coulter CL, Robinson JS, McMillen IC, 'Infusion of metyrapone transiently suppresses cortisol biosynthesis at 125D gestation and results in a decreased response of fetal arterial blood pressure to angiotensin II after 135D gestation', PEDIATRIC RESEARCH, BRIGHTON, ENGLAND (2003)
Author URL
2003Muhlhausler BS, Schultz C, Chatterton BE, McMillen IC, 'Adiposity is positively correlated with weight gain over the first 6 months of postnatal life in female sheep', PEDIATRIC RESEARCH, BRIGHTON, ENGLAND (2003)
Author URL
2003De Blasio M, Walker MR, Gafford KL, Fielke SL, McMillen IC, Robinson JS, Owens JA, 'Placental restriction of fetal growth decreases size at birth and increases postnatal growth rate and adiposity in the neonatal lamb', PEDIATRIC RESEARCH, BRIGHTON, ENGLAND (2003)
Author URL
2003Gatford KL, De Blasio ML, Thavaneswaran P, McMillen IC, Robinson JS, Owens JA, 'Restricted fetal growth and neonatal catchup growth are associated with sexually dimorphic outcomes for insulin secretion in the young adult sheep', PEDIATRIC RESEARCH, BRIGHTON, ENGLAND (2003)
Author URL
2003Buckley P, Muscat V, McMillen IC, 'Increased maternal contact in early life alters adiposity and changes the relationship between birth phenotype and cortisol in the young adult male guinea pig', PEDIATRIC RESEARCH, BRIGHTON, ENGLAND (2003)
Author URL
2001Schwartz J, McMillen IC, 'Fetal hypothalamus-pituitary-adrenal axis on the road to parturition', CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, AUSTRALIA (2001) [E1]
DOI10.1046/j.1440-1681.2001.03412.xAuthor URL
CitationsScopus - 12Web of Science - 10
2001McMillen IC, Owens JA, Coulter CL, Robinson JS, 'Introduction: Moving on from controversies to mechanisms', CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY (2001) [E1]
Author URL
CitationsScopus - 2
2001Edwards LJ, Coulter CL, Symonds ME, McMillen IC, 'Prenatal undernutrition, glucocorticoids and the programming of adult hypertension', CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, SYDNEY, AUSTRALIA (2001) [E1]
DOI10.1046/j.1440-1681.2001.03553.xAuthor URL
CitationsScopus - 47Web of Science - 40
1998Kerswell J, Symonds ME, Owens JA, Mundy L, Warnes K, McMillen IC, 'Maternal nutrition during late gestation and placental weight and conformation in sheep', Early Human Development (1998) [E3]
1998Robinson JS, McMillen IC, Fielke S, Evans L, Lok F, Owens JA, 'Role of placenta: Development and function', Equine Veterinary Journal (1998) [E3]
CitationsScopus - 7
1998Owens JA, McMillen C, Gatford K, Moore V, Robinson J, Kind K, Clifton P, 'Prenatal programming of metabolic homeostasis: Comparative studies in the guinea pig, sheep and human', Equine Veterinary Journal (1998) [E3]
1997Symonds ME, Phillips ID, Anthony RV, McMillen IC, 'Ontogenic and nutritional influences on prolactin receptor mRNA in perirenal adipose tissue from the sheep fetus', Early Human Development, London, UK (1997) [E3]
CitationsScopus - 2
1993MCMILLEN IC, LIM MEH, ADAMSON TM, MULVOGUE HM, 'DEVELOPMENT OF CIRCADIAN SLEEP-WAKE RHYTHMS IN TERM AND PRETERM INFANTS - INFLUENCE OF EXPOSURE TO LIGHT-DARK CYCLES IN A PRETERM NURSERY', SECOND SIDS INTERNATIONAL CONFERENCE AND FIRST SIDS GLOBAL STRATEGY MEETING, SYDNEY, AUSTRALIA (1993)
Author URL
1993MCMILLEN IC, YOUNG IR, HOUGHTON D, WALKER DW, 'FETAL RHYTHMS', PROGRESS IN ENDOCRINOLOGY, NICE, FRANCE (1993)
Author URL
1991MCMILLEN IC, WALKER DW, 'CHANGES IN THE EXTERNAL LIGHTING REGIME ALTER DAILY BEHAVIORAL AND HORMONAL RHYTHMS IN THE PREGNANT EWE AND SHEEP FETUS DURING LATE GESTATION', ADVANCES IN PINEAL RESEARCH : 6, BOWRAL, AUSTRALIA (1991)
Author URL
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News

Health and Medical Sciences Academy

Academy honour for UON leaders

March 26, 2015

Two University of Newcastle (UON) research leaders are among the distinguished health and medical scientists elected this week as Fellows of the Australian Academy of Health and Medical Sciences (AAHMS).

New Colombo Plan Fellows

New Colombo Plan Scholars

June 27, 2014

Three of UON's best and brightest undergraduates have been awarded prestigious scholarships under the Australian Government's New Colombo Plan to study in the Asia Pacific region.

CEO Sleepout

June 16, 2014

University of Newcastle Vice-Chancellor, Professor Caroline McMillen, will again trade her bed for cardboard sheets to raise awareness and funds for homeless Australians as part of Vinnies CEO Sleepout on Thursday 19 June.

pathways

UON welcomes greater support for entry pathways

April 14, 2014

University of Newcastle Vice-Chancellor, Professor Caroline McMillen, has welcomed the report of the review of the Demand Driven Funding System released by the Australian Government, and the recommendations for the expansion and improvement of the system.

Equity

Equity Education

November 14, 2013

The University of Newcastle is proposing targeted support for institutions providing first-rate education for students from equity groups in response to the recently announced Review of the Demand Driven System.

The Conversation

A Vice-Chancellor’s defence of the uncapped university system

September 26, 2013

By Caroline McMillen.

As the new government settles in, there has been heated speculation around major changes to the higher education system. Education minister Christopher Pyne's comments to the media have raised questions across the sector about the Coalition's vision for universities in Australia.

Top 200 QS Ranking

Disciplines ranked in top 200 in the world

May 8, 2013

The University of Newcastle has ten disciplines which feature in the top 200 in the world, according to new QS World University Rankings published today.

Healthy University Fair

Professor Caroline McMillen opens Newcastle's Healthy University Fair

May 8, 2013

The University of Newcastle Vice-Chancellor Professor Caroline McMillen opened the University's inaugural Health Fair today to promote healthy lifestyles that enhance learning.

Lecture theatre with students

UoN backs unified higher education vision

February 27, 2013

The University of Newcastle said today's release of the university sector's first comprehensive higher education policy agenda was an important step in building Australia's future productivity and economic growth.

Professor Caroline McMillen

Position

Vice-Chancellor
Office of the Vice-Chancellor
Vice-Chancellor's Division

Contact Details

Emailcaroline.mcmillen@newcastle.edu.au
Phone(02) 4921 5101
Fax(02) 4921 5115

Office

BuildingThe Chancellery
LocationCallaghan
University Drive
Callaghan, NSW 2308
Australia
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