Dr Zakia Sultana
Haggarty Early Career Research Fellow
School of Medicine and Public Health
- Email:zakia.sultana@newcastle.edu.au
- Phone:(02) 402 20351
Career Summary
Biography
Dr Zakia Sultana is a Mid-Career Researcher within the Mother and Babies Research Program at the University of Newcastle. Dr Sultana received a Doctor of Philosophy (PhD) in Reproductive Medicine from the University of Newcastle in August 2018. Dr Sultana's academic journey includes a Bachelor of Pharmacy and a Master of Pharmacy from Rajshahi University, Bangladesh.
During her PhD, Dr Sultana's research was centred on the discovery of potential biomarkers for oxidative damage and aging in placentas during pathologic pregnancies. She developed in vitro models using human placental tissue explants and placental cell lines to investigate the mechanisms underlying oxidative damage and aging in pathologic pregnancies. Her work also unveiled potential therapeutic targets for mitigating oxidative damage and premature aging in high-risk pregnancies. Dr Sultana's findings have been published in prestigious journals, and she received an Early Career Research (ECR) fellowship as the lead investigator for her study on placental aging.
Currently, Dr Sultana's research interests encompass aging and aging-related disorders, where she leverages her expertise in molecular biology and medical biochemistry to advance understanding of the molecular mechanisms involved in the aging process and identify potential therapeutic targets. She leads projects on placental aging, UV radiation and skin damage, and oxidative damage and brain aging, in addition to co-supervising two PhD students.
Dr Sultana possesses a comprehensive research skillset, demonstrating expertise in molecular and cell biology and medical biochemistry. Her proficiency extends to fundamental laboratory techniques, including cell and tissue culture, Real-time qPCR, CRISPR-Cas9, siRNA-based gene silencing, protein analysis, immunohistochemistry, western blotting, ELISA, Confocal laser scanning microscopy, optical microscopy, and animal studies.
Qualifications
- Doctor of Philosophy, University of Newcastle
- Bachelor of Pharmacy (Honours), University of Rajshahi - Bangladesh
- Master of Pharmacy, University of Rajshahi - Bangladesh
Keywords
- Aging
- Biological Sciences
- Cell Biology
- Medical Biochemistry
- Metabolism
- Mitochondria
- Molecular Biology
- Pregnancy
- Reproductive Medicine
- Reproductive Sciences
Languages
- English (Fluent)
- Bengali (Mother)
Fields of Research
Code | Description | Percentage |
---|---|---|
320599 | Medical biochemistry and metabolomics not elsewhere classified | 50 |
321599 | Reproductive medicine not elsewhere classified | 50 |
Professional Experience
UON Appointment
Title | Organisation / Department |
---|---|
Haggarty Early Career Research Fellow | University of Newcastle School of Medicine and Public Health Australia |
Academic appointment
Dates | Title | Organisation / Department |
---|---|---|
1/4/2020 - | Haggarty Early Career Research Fellow | School of Medicine and Public Health, The University of Newcastle Australia |
Professional appointment
Dates | Title | Organisation / Department |
---|---|---|
1/11/2018 - |
First Aid Officer (Volunteer) Provide First Aid |
Hunter Medical Research Institute (HMRI) Australia |
31/1/2018 - 31/3/2020 | Research Assistant | School of Medicine & Public Health, Faculty of Health & Medicine, University of Newcastle | Australia Australia |
Awards
Scholarship
Year | Award |
---|---|
2019 |
Society of Reproductive Investigation Travel Award Society of Reproductive Investigation |
2014 |
University of Newcastle International Postgraduate Research Scholarship (UNIPRS) University of Newcastle - Faculty of Health and Medicine, School of Medicine and Public Health |
2014 |
University of Newcastle Research Central 50/50 (UNRSC5050) University of Newcastle - Faculty of Health and Medicine, School of Medicine and Public Health |
Publications
For publications that are currently unpublished or in-press, details are shown in italics.
Journal article (16 outputs)
Year | Citation | Altmetrics | Link | ||||||||
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2024 |
Paul N, Maiti K, Sultana Z, Fisher JJ, Zhang H, Cole N, et al., 'Human placenta releases extracellular vesicles carrying corticotrophin releasing hormone mRNA into the maternal blood', Placenta, 146 71-78 (2024) [C1]
|
Nova | |||||||||
2023 |
Paul N, Sultana Z, Fisher JJ, Maiti K, Smith R, 'Extracellular vesicles- crucial players in human pregnancy.', Placenta, 140 30-38 (2023) [C1]
|
Nova | |||||||||
2023 |
Sultana Z, Qiao Y, Maiti K, Smith R, 'Involvement of oxidative stress in placental dysfunction, the pathophysiology of fetal death and pregnancy disorders.', Reproduction, 166 R25-R38 (2023) [C1]
|
Nova | |||||||||
2020 |
Qiao Y, Maiti K, Sultana Z, Fu L, Smith R, 'Inhibition of vertebrate aldehyde oxidase as a therapeutic treatment for cancer, obesity, aging and amyotrophic lateral sclerosis', European Journal of Medicinal Chemistry, 187 (2020) [C1]
|
Nova | |||||||||
2018 |
Sultana Z, Maiti K, Dedman L, Smith R, 'Is there a role for placental senescence in the genesis of obstetric complications and fetal growth restriction?', American Journal of Obstetrics and Gynecology, 218 S762-S773 (2018) [C1]
|
Nova | |||||||||
2017 |
Maiti K, Sultana Z, Aitken RJ, Morris J, Park F, Andrew B, et al., 'Evidence that fetal death is associated with placental aging.', American journal of obstetrics and gynecology, 217 441.e1-441.e14 (2017) [C1]
|
Nova | |||||||||
2017 |
Sultana Z, Maiti K, Aitken J, Morris J, Dedman L, Smith R, 'Oxidative stress, placental ageing-related pathologies and adverse pregnancy outcomes', AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 77 (2017) [C1]
|
Nova | |||||||||
2014 |
Begum MM, Sultana Z, Ershad Ali M, Jami MSI, Khondkar P, Khan MM, Haque MM, 'Additive effect of lipid lowering drug (simvastatin) in combination with antidiabetic drug (glibenclamide) on alloxan induced diabetic rats with long term dyslipidemia.', Indian J Clin Biochem, 29 452-461 (2014)
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Show 13 more journal articles |
Conference (10 outputs)
Year | Citation | Altmetrics | Link | ||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
2023 |
Paul N, Smith R, Maiti K, Sultana Z, 'Release of Placental Corticotropin-Releasing Hormone mRNA within Extracellular Vesicles is Inhibited by Nitric Oxide', Reproductive Sciences, Brisbane, QLD (2023)
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2021 |
Paul N, Maiti K, Sultana Z, Smith R, 'Human placental release of Corticotropin-Releasing Hormone (CRH) mRNA within extracellular vesicles (EVs) is inhibited by nitric oxide', Placenta, Virtual (2021)
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2021 |
Maiti K, Foteva V, Sultana Z, Qiao Y, Smith R, 'Molybdenum and molybdoenzymes in placental physiology and pathology', Placenta, Virtual (2021)
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2015 |
Maiti K, Sultana Z, Aitken J, Smith R, 'THE HUMAN PLACENTA AT 41 WEEKS OF GESTATION SHOWS EVIDENCE OF AGING WITH SHORTENED TELOMERES, DNA OXIDATION AND CHANGES IN IGFR2, AUTOPHAGY AND MTOR', PLACENTA (2015) [E3]
|
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2015 |
Maiti K, Aitken J, Smith R, 'The Human Placenta at 41 Weeks of Gestation Shows Evidence of Aging With Shortened Telomeres, DNA Oxidation and Changes in IGFR2, Autophagy and the mTOR', REPRODUCTIVE SCIENCES (2015) [E3]
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2015 |
Sultana Z, Maiti K, Smith R, 'USE OF AN IN VITRO HUMAN PLACENTAL EXPLANT CULTURE MODEL TO INTERROGATE THE EFFECTS OF STARVATION ON PLACENTAL FUNCTION', PLACENTA (2015) [E3]
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Show 7 more conferences |
Grants and Funding
Summary
Number of grants | 9 |
---|---|
Total funding | $1,270,841 |
Click on a grant title below to expand the full details for that specific grant.
20231 grants / $14,767
Preventing UV-induced DNA damage, aging and cancer in the skin$14,767
Funding body: Hunter New England Local Health District
Funding body | Hunter New England Local Health District |
---|---|
Project Team | Doctor Zakia Sultana, Laureate Professor Roger Smith |
Scheme | John Hunter Hospital Charitable Trust Grant |
Role | Lead |
Funding Start | 2023 |
Funding Finish | 2023 |
GNo | G2301028 |
Type Of Funding | C2400 – Aust StateTerritoryLocal – Other |
Category | 2400 |
UON | Y |
20221 grants / $9,853
Development of targeted liposomes to localize abnormal parathyroid glands$9,853
Funding body: School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of newcastle
Funding body | School of Medicine and Public Health, College of Health, Medicine and Wellbeing, University of newcastle |
---|---|
Project Team | Yixue Qiao, Zakia Sultana |
Scheme | School of Medicine & Public Health Pilot Grant |
Role | Investigator |
Funding Start | 2022 |
Funding Finish | 2022 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
20211 grants / $18,182
Mechanisms of release of placental extracellular vesicles containing corticotropin releasing hormone messenger RNA into maternal blood.$18,182
Funding body: John Hunter Hospital Charitable Trust
Funding body | John Hunter Hospital Charitable Trust |
---|---|
Project Team | Zakia Sultana, Rajyalakshmi Kasi |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2021 |
Funding Finish | 2021 |
GNo | |
Type Of Funding | C3112 - Aust Not for profit |
Category | 3112 |
UON | N |
20202 grants / $1,202,310
Placental Aging and Adverse Pregnancy Outcomes: Understanding the Biochemical Pathway and the Mechanism of Aging of the Placenta Following Oxidative Stress$1,190,148
Funding body: The Haggarty Foundation
Funding body | The Haggarty Foundation |
---|---|
Project Team | Doctor Zakia Sultana |
Scheme | Research Funding |
Role | Lead |
Funding Start | 2020 |
Funding Finish | 2027 |
GNo | G2000485 |
Type Of Funding | C3200 – Aust Not-for Profit |
Category | 3200 |
UON | Y |
Placental Aging and Adverse Pregnancy Outcomes: Understanding the Biochemical Pathway and the Mechanism of Aging of Placental Cells Following Oxidative Stress$12,162
Funding body: John Hunter Hospital Charitable Trust
Funding body | John Hunter Hospital Charitable Trust |
---|---|
Project Team | Zakia Sultana, Rajyalakshmi Kasi |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2020 |
Funding Finish | 2020 |
GNo | |
Type Of Funding | C3112 - Aust Not for profit |
Category | 3112 |
UON | N |
20194 grants / $25,729
Understanding the Biochemistry and Molecular Mechanism of Aging of the Placenta in Pathologic Pregnancy$20,063
Funding body: John Hunter Hospital Charitable Trust
Funding body | John Hunter Hospital Charitable Trust |
---|---|
Project Team | Doctor Zakia Sultana, Dr Felicity Park |
Scheme | Research Grant |
Role | Lead |
Funding Start | 2019 |
Funding Finish | 2019 |
GNo | G1901078 |
Type Of Funding | C3200 – Aust Not-for Profit |
Category | 3200 |
UON | Y |
Novel inhibitors of Aldehyde Oxidase 1 to prevent ultraviolet light induced skin aging and cancer$4,000
Funding body: University of Newcastle - Faculty of Health and Medicine, School of Medicine and Public Health
Funding body | University of Newcastle - Faculty of Health and Medicine, School of Medicine and Public Health |
---|---|
Scheme | Small Grant Funding 2019 |
Role | Lead |
Funding Start | 2019 |
Funding Finish | 2019 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
Priority Research Centre for Reproductive Science Strategic Support$1,000
Funding body: PRC for Reproductive Science, University of Newcastle
Funding body | PRC for Reproductive Science, University of Newcastle |
---|---|
Scheme | Travel support |
Role | Lead |
Funding Start | 2019 |
Funding Finish | 2019 |
GNo | |
Type Of Funding | Internal |
Category | INTE |
UON | N |
Society of Reproductive Investigation Travel Award $666
Funding body: Society for Reproductive Investigation
Funding body | Society for Reproductive Investigation |
---|---|
Scheme | Travel support |
Role | Lead |
Funding Start | 2019 |
Funding Finish | 2019 |
GNo | |
Type Of Funding | International - Competitive |
Category | 3IFA |
UON | N |
Research Supervision
Number of supervisions
Current Supervision
Commenced | Level of Study | Research Title | Program | Supervisor Type |
---|---|---|---|---|
2021 | PhD | The Development of Aldehyde Oxidase 1 Inhibitors | PhD (Clinical Pharm), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
2019 | PhD | Placental Release of Extracellular Vesicles Containing Corticotrophin Releasing Hormone mRNA during Human Pregnancy | PhD (Reproductive Medicine), College of Health, Medicine and Wellbeing, The University of Newcastle | Co-Supervisor |
Research Collaborations
The map is a representation of a researchers co-authorship with collaborators across the globe. The map displays the number of publications against a country, where there is at least one co-author based in that country. Data is sourced from the University of Newcastle research publication management system (NURO) and may not fully represent the authors complete body of work.
Country | Count of Publications | |
---|---|---|
Australia | 15 | |
Bangladesh | 2 | |
United Kingdom | 2 | |
China | 1 | |
United States | 1 |
Dr Zakia Sultana
Position
Haggarty Early Career Research Fellow
Mothers and Babies Research Centre
School of Medicine and Public Health
College of Health, Medicine and Wellbeing
Contact Details
zakia.sultana@newcastle.edu.au | |
Phone | (02) 402 20351 |
Fax | (02) 4920351 |
Office
Room | HMRI 3401 (Level 3 East) |
---|---|
Building | Hunter Medical Research Institute |
Location | Hunter Medical Research Institute , |