Dr Roshan Gunathilake

Dr Roshan Gunathilake

Conjoint Lecturer

School of Medicine and Public Health

Career Summary

Biography

I work as a Consultant Geriatrician and General Physician at the John Hunter Hospital with a conjoint appointment with University of Newcastle. I completed my physician training in Queensland and Newcastle, obtaining fellowship with the Royal Australasian College of Physicians (RACP) in 2015. 

In the early stages of my medical career, I was interested in becoming a dermatologist and I was fascinated by human skin biology. I have worked full-time as a postdoctoral research fellow in the University of California San Francisco between 2007 and 2009 before moving to Australia. My postdoctoral studies focused on the stratum corneum barrier function and keratinocyte-melanocyte interactions. After moving to Australia in 2009, I developed a passion for geriatric medicine and continued to research and publish in the field of geriatrics, with special interest in the epidemiology of geriatric syndromes. 

I am involved in teaching undergraduate medical students and basic physician trainees as well as supervising geriatric medicine advanced trainees. I have represented physician trainees in educational committees both in the College and HETI NSW and involved in the development of RACP Online Learning Resources for advanced training research projects.


Qualifications

  • Doctor of Medicine, University of Colombo, Sri Lanka
  • Bachelor of Medicine, Bachelor of Surgery, University of Colombo, Sri Lanka

Keywords

  • Internal Medicine
  • Orthogeriatrics
  • dermatology
  • geriatric medicine
  • geriatrics
  • gerontology

Fields of Research

Code Description Percentage
320210 Geriatrics and gerontology 100

Professional Experience

Academic appointment

Dates Title Organisation / Department
1/1/2017 -  Conjoint Lecturer School of Medicine & Public Health, Faculty of Health & Medicine, University of Newcastle | Australia
Australia

Professional appointment

Dates Title Organisation / Department
1/7/2017 -  Visiting Geriatrician & Consultant Physician Lake Macquarie Private Hospital
Australia
1/2/2016 -  Staff Specialist in General Medicine & Geriatric Medicine John Hunter Hospital
Medicine and Interventional Services
Australia

Awards

Prize

Year Award
2014 Prof Tony Broe Award in Geriatric Medicine
Australia & New Zealand Society of Geriatric Medicine

Scholarship

Year Award
2013 IMSANZ Advanced Trainee Travelling Scholarship
Internal Medicine Society of Australia & New Zealand
2008 World Congress Fund Travel Fellowship
American Academy of Dermatology
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Publications

For publications that are currently unpublished or in-press, details are shown in italics.


Chapter (1 outputs)

Year Citation Altmetrics Link
2018 Gunathilake R, Nair BKR, 'Acute care and geriatric assessment', Geriatric Medicine: A Problem-Based Approach, Springer, Singapore 137-151 (2018) [B1]
DOI 10.1007/978-981-10-3253-0_10
Co-authors Kichu Nair

Journal article (17 outputs)

Year Citation Altmetrics Link
2016 Gunathilake R, Epstein E, McNeill S, Walsh B, 'Factors associated with receiving anti-osteoporosis treatment among older persons with minimal trauma hip fracture presenting to an acute orthogeriatric service', Injury, 47 2149-2154 (2016) [C1]

Background/Aim The aim of this study was to investigate factors that were associated with receiving anti-osteoporosis treatment (AOT) among patients with minimal trauma hip fractu... [more]

Background/Aim The aim of this study was to investigate factors that were associated with receiving anti-osteoporosis treatment (AOT) among patients with minimal trauma hip fracture admitted to an Australian tertiary trauma centre under the Acute Orthogeriatric Service (AOS) over a 6 month period. Design Observational study using prospectively collected data. Methods Demographic and clinical characteristics of 211 patients were extracted from the local hip fracture registry and electronic medical records. The outcome measure was receipt of AOT before separation from the AOS. Binary logistic regression was used to identify factors independently associated with treatment. Results 91 (45%) patients received AOT, including 51 (25.2%) treatment-naive patients. Factors significantly associated with receiving treatment included higher serum vitamin D level (OR 1.44, 95% CI 1.23¿1.70, p¿<¿0.001) and trochanteric vs. cervical fracture (OR 2.67, 95% CI 1.30¿5.49, p¿=¿0.007). Living in a residential aged care facility (RACF) prior to the index fracture (OR 0.2, 95% CI 0.08¿0.54, p¿=¿0.001) and higher American Society of Anaesthesiologists (ASA) physical status score (OR 0.5, 95% CI 0.25¿0.98, p¿=¿0.04) significantly lowered the likelihood of treatment. Age, gender, cognitive impairment, premorbid walking ability, previous fragility fracture and renal impairment did not correlate with treatment. Conclusion A significant proportion (55%) of hip fracture patients did not receive AOT in hospital. The probability of receiving treatment appears to be significantly associated with serum vitamin D level, fracture type, place of residence and comorbidity burden.

DOI 10.1016/j.injury.2016.07.034
Citations Scopus - 2Web of Science - 2
2016 Gunathilake R, Oldmeadow C, McEvoy M, Inder KJ, Schofield PW, Nair BR, Attia J, 'The Association Between Obesity and Cognitive Function in Older Persons: How Much Is Mediated by Inflammation, Fasting Plasma Glucose, and Hypertriglyceridemia?', J Gerontol A Biol Sci Med Sci, 71 1603-1608 (2016) [C1]
DOI 10.1093/gerona/glw070
Citations Scopus - 15Web of Science - 11
Co-authors Christopher Oldmeadow, Peter Schofield, Mark Mcevoy, Kerry Inder, John Attia, Kichu Nair
2015 Gunathilake R, 'The human epidermal antimicrobial barrier: Current knowledge, clinical relevance and therapeutic implications', Recent Patents on Anti-Infective Drug Discovery, 10 84-97 (2015) [C1]

Most of the defensive functions of the human skin are localized to the stratum corneum (SC), the outermost layer of the epidermis consisting of several layers of cornified keratin... [more]

Most of the defensive functions of the human skin are localized to the stratum corneum (SC), the outermost layer of the epidermis consisting of several layers of cornified keratinocytes embedded in a lipid matrix. Included in the armamentarium of the epidermal barrier against microbial invasion are surface pH, SC lipids, specialized antimicrobial peptides such as defensins and cathelicidins, enzymes and enzyme inhibitors, chemokines, and epidermal Toll-like receptors. Multiple epidermal defensive mechanisms are co-localized, coregulated, and intertwined. The purpose of this review is to discuss patents and to describe the current knowledge that concerns the role of the epidermis as an antimicrobial barrier, outlining potential clinical and therapeutic implications.

DOI 10.2174/1574891X10666150623093446
Citations Scopus - 4
2015 Gunathilake R, Verma A, Caffery M, Sowden S, 'Pasteurella Multocida Peritonitis After Cat Scratch in a Patient with Cirrhotic Ascites.', Infectious disease reports, 7 5937 (2015) [C3]
DOI 10.4081/idr.2015.5937
Citations Scopus - 3Web of Science - 4
2014 Gunathilake R, Krishnamurthy V, Oldmeadow C, Kerr E, Padmakumar C, Attia J, et al., 'Relationships between age, other predictive variables, and the 90-day functional outcome after intravenous thrombolysis for acute ischemic stroke', AUSTRALASIAN JOURNAL ON AGEING, 33 19-19 (2014) [E3]
Co-authors Mark Parsons, Christopher Levi, Christopher Oldmeadow, John Attia
2014 Gunathilake R, Krishnamurthy V, Oldmeadow C, Kerr E, Padmakumar C, Attia J, et al., 'Relationships between age, other predictive variables, and the 90-day functional outcome after intravenous thrombolysis for acute ischemic stroke', International Journal of Stroke, 9 E36-E37 (2014) [O1]
DOI 10.1111/ijs.12347
Citations Scopus - 1Web of Science - 1
Co-authors Christopher Oldmeadow, Christopher Levi, John Attia, Mark Parsons
2014 Gunathilake R, Perera P, Sirimanna G, 'Curvularia lunata: A rare cause of black-grain eumycetoma', Journal de Mycologie Medicale, 24 158-160 (2014) [C3]

Curvularia lunata is a dematiaceous fungus that rarely causes cutaneous infections in immunocompetent humans. We describe a case of mycetoma pedis caused by Curvularia lunata in a... [more]

Curvularia lunata is a dematiaceous fungus that rarely causes cutaneous infections in immunocompetent humans. We describe a case of mycetoma pedis caused by Curvularia lunata in a 50-year-old woman from a rural farming community who had prolonged morbidity due to diagnostic delay. She improved with antifungal therapy, showing a satisfactory clinical response after 12. months of treatment. © 2013 Elsevier Masson SAS.

DOI 10.1016/j.mycmed.2013.09.005
Citations Scopus - 5Web of Science - 1
2014 Gunathilake R, Lowe D, Wills J, Knight A, Braude P, 'Implementation of a multicomponent intervention to optimise patient safety through improved oxygen prescription in a rural hospital', AUSTRALIAN JOURNAL OF RURAL HEALTH, 22 328-333 (2014) [C1]
DOI 10.1111/ajr.12115
Citations Scopus - 6Web of Science - 4
Co-authors Anne Knight
2013 Gunathilake R, Oldmeadow C, McEvoy M, Kelly B, Inder K, Schofield P, Attia J, 'Mild Hyponatremia Is Associated With Impaired Cognition And Falls In Community-Dwelling Older Persons', Journal of the American Geriatrics Society, 61 1838-1839 (2013) [C1]
DOI 10.1111/jgs.12468
Citations Scopus - 40Web of Science - 39
Co-authors Mark Mcevoy, Peter Schofield, Christopher Oldmeadow, Kerry Inder, John Attia, Brian Kelly
2013 Gunathilake R, Boyce LE, Knight AT, 'Pregabalin-associated rhabdomyolysis', MEDICAL JOURNAL OF AUSTRALIA, 199 624-625 (2013) [C3]
DOI 10.5694/mja13.10769
Citations Scopus - 6Web of Science - 8
Co-authors Anne Knight
2013 Gunathilake R, 'Tap water iontophoresis versus glycopyrrolate iontophoresis', AUSTRALIAN FAMILY PHYSICIAN, 42 441-441 (2013)
Citations Scopus - 1Web of Science - 1
2010 Gunathilake R, Schmuth M, Scharschmidt TC, Gruber R, Grabher D, Leslie KS, et al., 'Epidermal Barrier Dysfunction in Non-Atopic HIV: Evidence for an "Inside-to-Outside'' Pathogenesis', JOURNAL OF INVESTIGATIVE DERMATOLOGY, 130 1185-1188 (2010)
DOI 10.1038/jid.2009.367
Citations Scopus - 13Web of Science - 9
2009 Gunathilake R, Schurer NY, Shoo BA, Celli A, Hachem J-P, Crumrine D, et al., 'pH-Regulated Mechanisms Account for Pigment-Type Differences in Epidermal Barrier Function', JOURNAL OF INVESTIGATIVE DERMATOLOGY, 129 1719-1729 (2009)
DOI 10.1038/jid.2008.442
Citations Scopus - 96Web of Science - 77
2009 Scharschmidt TC, Man M-Q, Hatano Y, Crumrine D, Gunathilake R, Sundberg JP, et al., 'Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens', JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 124 496-U164 (2009)
DOI 10.1016/j.jaci.2009.06.046
Citations Scopus - 203Web of Science - 180
2008 Elias PM, Arbiser J, Brown BE, Rossiter H, Man M-Q, Cerimele F, et al., 'Epidermal vascular endothelial growth factor production is required for permeability barrier homeostasis, dermal angiogenesis, and the development of epidermal hyperplasia - Implications for the pathogenesis of psoriasis', AMERICAN JOURNAL OF PATHOLOGY, 173 689-699 (2008)
DOI 10.2353/ajpath.2008.080088
Citations Scopus - 70Web of Science - 60
2007 Gunathilake HMDR, Sirimanna GMP, Schürer NY, 'The pH of commercially available rinse-off products in Sri Lanka and their effect on skin pH.', The Ceylon medical journal, 52 125-129 (2007)
DOI 10.4038/cmj.v52i4.913
2001 Thalwattegedera CC, Gunathilake HM, Weerasuriya K, 'Direct to consumer advertising; the right tool in the wrong hands?', The Ceylon medical journal, 46 37-39 (2001)
DOI 10.4038/cmj.v46i2.6486
Show 14 more journal articles

Conference (6 outputs)

Year Citation Altmetrics Link
2017 Hayes H, Gunathilake R, Epstein E, McNeill S, 'Does orthogeriatric care improve the diagnosis and management of delirium in older persons with hip fracture?', AUSTRALASIAN JOURNAL ON AGEING (2017)
2014 Gunathilake R, Krishnamurthy V, Oldmedow C, Kerr E, Padmakumar C, Attia J, et al., 'Relationships between age, other predictive variables and the 90-day functional outcome after intravenous thrombolysis for acute ischemic stroke', INTERNATIONAL JOURNAL OF STROKE (2014) [E3]
Co-authors Christopher Oldmeadow, John Attia, Christopher Levi, Mark Parsons
2009 Gunathilake R, Schmuth M, Scharschmidt TC, Mauro TM, Maurer TA, Kieron LS, Elias PM, 'Epidermal barrier dysfunction in HIV: Relationship to immune status, antiretroviral therapy, and atopy', JOURNAL OF INVESTIGATIVE DERMATOLOGY, Montreal, CANADA (2009)
2009 Gruber R, Crumrine D, Sandilands A, Gunathilake R, Hachem JP, Presland RB, et al., 'Decreased filaggrin expression results in impaired epidermal barrier function in ichthyosis vulgaris', JOURNAL OF INVESTIGATIVE DERMATOLOGY, Budapest, HUNGARY (2009)
2009 'Abstracts of the 39th Annual European Society for Dermatological Research (ESDR) Meeting. September 9-12, 2009. Budapest, Hungary.', The Journal of investigative dermatology (2009)
DOI 10.1038/jid.2009.232
2008 Elias PM, Arbiser J, Brown BE, Rossiter H, Man M, Cerimele F, et al., 'Epidermal VEGF is required for permeability barrier homeostasis, dermal angiogenesis and development of epidermal hyperplasia: implications for the provocation of psoriasis', JOURNAL OF INVESTIGATIVE DERMATOLOGY, Kyoto, JAPAN (2008)
Citations Web of Science - 1
Show 3 more conferences
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Dr Roshan Gunathilake

Position

Conjoint Lecturer
School of Medicine and Public Health
College of Health, Medicine and Wellbeing

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