| 2023 |
Van Eeckhoutte HP, Donovan C, Kim RY, Conlon TM, Ansari M, Khan H, Jayaraman R, Hansbro NG, Dondelinger Y, Delanghe T, Beal AM, Geddes B, Bertin J, Vanden Berghe T, De Volder J, Maes T, Vandenabeele P, Vanaudenaerde BM, Deforce D, Skevin S, Van Nieuwerburgh F, Verhamme FM, Joos GF, Idrees S, Schiller HB, Yildirim AO, Faiz A, Bertrand' MJM, Brusselle GG, Hansbro PM, Bracke KR, 'RIPK1 kinase-dependent inflammation and cell death contribute to the pathogenesis of COPD', EUROPEAN RESPIRATORY JOURNAL, 61 (2023) [C1]
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Open Research Newcastle |
| 2022 |
Runtsch MC, Angiari S, Hooftman A, Wadhwa R, Zhang Y, Zheng Y, Spina JS, Ruzek MC, Argiriadi MA, McGettrick AF, Mendez RS, Zotta A, Peace CG, Walsh A, Chirillo R, Hams E, Fallon PG, Jayamaran R, Dua K, Brown AC, Kim RY, Horvat JC, Hansbro PM, Wang C, O'Neill LAJ, 'Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages', CELL METABOLISM, 34, 487-+ (2022) [C1]
The Krebs cycle-derived metabolite itaconate and its derivatives suppress the inflammatory response in pro-inflammatory "M1" macrophages. However, alternative... [more]
The Krebs cycle-derived metabolite itaconate and its derivatives suppress the inflammatory response in pro-inflammatory "M1" macrophages. However, alternatively activated "M2" macrophages can take up itaconate. We therefore examined the effect of itaconate and 4-octyl itaconate (OI) on M2 macrophage activation. We demonstrate that itaconate and OI inhibit M2 polarization and metabolic remodeling. Examination of IL-4 signaling revealed inhibition of JAK1 and STAT6 phosphorylation by both itaconate and OI. JAK1 activation was also inhibited by OI in response to IL-13, interferon-ß, and interferon-¿ in macrophages and in T helper 2 (Th2) cells. Importantly, JAK1 was directly modified by itaconate derivatives at multiple residues, including cysteines 715, 816, 943, and 1130. Itaconate and OI also inhibited JAK1 kinase activity. Finally, OI treatment suppressed M2 macrophage polarization and JAK1 phosphorylation in vivo. We therefore identify itaconate and OI as JAK1 inhibitors, suggesting a new strategy to inhibit JAK1 in M2 macrophage-driven diseases.
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Open Research Newcastle |
| 2022 |
Donovan C, Kim RY, Galvao I, Jarnicki AG, Brown AC, Jones-Freeman B, Gomez HM, Wadhwa R, Hortle E, Jayaraman R, Khan H, Pickles S, Sahu P, Chimankar V, Tu X, Ali MK, Mayall JR, Nguyen DH, Budden KF, Kumar V, Schroder K, Ab Robertson A, Cooper MA, Ab Wark P, Oliver BG, Horvat JC, Hansbro PM, 'Aim2 suppresses cigarette smoke-induced neutrophil recruitment, neutrophil caspase-1 activation and anti-Ly6G-mediated neutrophil depletion', IMMUNOLOGY AND CELL BIOLOGY, 100, 235-249 (2022) [C1]
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Open Research Newcastle |
| 2021 |
Pinkerton JW, Kim RY, Koeninger L, Armbruster NS, Hansbro NG, Brown AC, Jayaraman R, Shen S, Malek N, Cooper MA, Nordkild P, Horvat JC, Jensen BAH, Wehkamp J, Hansbro PM, 'Human ß-defensin-2 suppresses key features of asthma in murine models of allergic airways disease', CLINICAL AND EXPERIMENTAL ALLERGY, 51, 120-131 (2021) [C1]
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Open Research Newcastle |
| 2021 |
Jayaraman Y, Veeraraghavan B, Girish Kumar CP, Sukumar B, Rajkumar P, Kangusamy B, Verghese VP, Varghese R, Jayaraman R, Kapoor AN, Gupta N, Kanagasabai K, David JK, Rajaraman J, Sockalingam G, Khera A, Haldar P, Aggarwal MK, Pillai RK, Manchanda V, Theodore RBJ, Rajahamsan J, Mohan G, Jayalekshmi V, Nedunchelian K, Devasena N, Sridharan S, Selvi R, Ravinder T, Narayana Babu R, Mathevan G, Sugumari C, Sugandhi Rao P, Kini PG, Dwibedi B, Kanga A, Grover N, Narayanan H, Mehendale SM, 'Hospital-based sentinel surveillance for bacterial meningitis in under-five children prior to the introduction of the PCV13 in India', Vaccine, 39, 3737-3744 (2021)
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| 2019 |
Jayaraman R, Varghese R, Kumar JL, Neeravi A, Shanmugasundaram D, Ralph R, Thomas K, Veeraraghavan B, 'Invasive pneumococcal disease in Indian adults: 11 years' experience', Journal of Microbiology, Immunology and Infection, 52, 736-742 (2019)
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| 2018 |
Manoharan A, Jayaraman R, 'Pneumococcal Vaccines', Indian Journal of Medical Microbiology, 36, 465-474 (2018)
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| 2018 |
Jayaraman Y, Mehendale S, Jayaraman R, Varghese R, Chethrapilly Purushothaman GK, Rajkumar P, Sukumar B, Pillai RK, Mohan G, Radhakrishnan DN, Sridharan S, Babu N, Ganesapillai M, Rao SP, Kar SK, Manchanda V, Kanga A, Verghese VP, Veeraraghavan B, 'Immunochromatography in CSF improves data on surveillance of S. pneumoniae meningitis in India', Journal of Infection and Public Health, 11, 735-738 (2018)
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| 2018 |
Veeraraghavan B, Lal B, Devanga Ragupathi NK, Neeravi IR, Jeyaraman R, Varghese R, Paul MM, Baskaran A, Ranjan R, 'First genome report on novel sequence types of Neisseria meningitidis: ST12777 and ST12778', Journal of Global Antimicrobial Resistance, 12, 117-118 (2018)
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| 2017 |
Varghese R, Jayaraman R, Veeraraghavan B, 'Current challenges in the accurate identification of Streptococcus pneumoniae and its serogroups/serotypes in the vaccine era', Journal of Microbiological Methods, 141, 48-54 (2017)
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| 2017 |
Verghese VP, Veeraraghavan B, Jayaraman R, Varghese R, Neeravi A, Jayaraman Y, Thomas K, Mehendale SM, 'Increasing Incidence of Penicillin- and Cefotaxime-resistant Streptococcus pneumoniae Causing Meningitis in India: Time for Revision of Treatment Guidelines?', Indian Journal of Medical Microbiology, 35, 228-236 (2017)
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| 2016 |
Veeraraghavan B, Jayaraman R, John J, Varghese R, Neeravi A, Verghese VP, Thomas K, 'Customized sequential multiplex PCR for accurate and early determination of invasive pneumococcal serotypes found in India', Journal of Microbiological Methods, 130, 133-135 (2016)
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| 2016 |
Gopi T, Ranjith J, Anandan S, Balaji V, 'Epidemiological characterisation of Streptococcus pneumoniae from India using multilocus sequence typing', Indian Journal of Medical Microbiology, 34, 17-21 (2016)
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| 2015 |
Balaji V, Jayaraman R, Verghese V, Baliga PR, Kurien T, 'Pneumococcal serotypes associated with invasive disease in under five children in India & implications for vaccine policy', Indian Journal of Medical Research, 142, 286-286 (2015)
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| 2015 |
Deodhar D, Varghese G, Balaji V, John J, Rebekah G, Janardhanan J, Jeyaraman R, Jasmine S, Mathews P, 'Prevalence of toxin genes among the clinical isolates of Staphylococcus aureus and its clinical impact', Journal of Global Infectious Diseases, 7, 97-97 (2015)
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| 2013 |
Molander V, Elisson C, Balaji V, Backhaus E, John J, Vargheese R, Jayaraman R, Andersson R, 'Invasive pneumococcal infections in Vellore, India: clinical characteristics and distribution of serotypes', BMC Infectious Diseases, 13 (2013)
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