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Associate Professor Mark Lucock

Associate Professor

School of Environmental and Life Sciences (Applied Sciences)

Career Summary

Biography

I arrived at the UoN in 2003. My formative academic years were spent at the University of Leeds, UK, where my lifetimes interest in vitamins, particularly folic acid, emerged out of the seminal work conducted by Leeds Paediatrician, Professor Dick Smithells. His work demonstrated how periconceptional folic acid supplementation could reduce the risk of neural tube defects like spina bifida. His work is considered to be one of the finest contemporary examples of preventative medicine.

Today, my overarching research interest is the role of diet in human ecology. I have established an international reputation in the field of nutritional genetics and epigenetics in relation to genes coding for proteins involved in vitamin D and folate/B vitamin metabolism and function. This is of major significance in defining important clinical phenotypes, and is of evolutionary and developmental relevance. As of June 2017, my authored publication list is 195 articles/chapters/books, and includes several very high impact factor (>20*) research articles (Nature*, Lancet*, BMJ, JNCI, PNAS). My total citation number is 3,036; the highest single paper citation count being 644 and my h index is 27. The scope of publications range from nutrient analysis and nutrient gene interactions to the role of B vitamins and vitamin D in human disease and evolutionary processes. A major theme throughout my career has been on developmental and degenerative conditions related to these vitamins (especially folic acid); in particular, studies have focused on birth defects, pregnancy complications, colon cancer, mood disorders, dementia, autism and cardiovascular disease. I've published several articles in each of these areas.

In 2007 I was sole author of an academic text book for students and researchers titled – Molecular Nutrition and Genomics: Nutrition & the Ascent of Humankind (Wiley). Most importantly, my research publications demonstrate extensive international collaboration (UK, Canada and US), have significant bearing on the fundamental mechanisms underpinning human disease and evolutionary processes, and have been reported in some very high profile journals and media.

Condensing my life's research focus into a single statement it would read: Vitamin biology (B vitamins, and vitamin D) and nutrigenetics, taking a lifecycle approach to human health with a focus on both developmental and degenerative disorders, to include the exposome and how it might interact with genes to alter human biology and disease.

More specific research foci include:

> Role of diet in human ecology (health, disease and evolutionary biology)

> Vitamin chemistry, biochemistry, genetics and evolutionary and health significance

> Vitamins in relation to common developmental and degenerative disorders (nutritional genetic perspective)

> Evolutionary medicine, particularly ancestral genes vs contemporary diet

> Developmental origins of adult disease/epigenetics

> Nutrients and healthy ageing

> Nutritional and natural product pharmacology

> Vitamin D, UV exposure and health

> Folic acid and its dependent genes in human biology

I am a Charted Biologist (CBiol), and an elected Fellow of the Royal Society of Biology (FRSB), London, a measure of esteem broadly equivalent to a DSc. I am also a Fellow of the Royal College of Pathologists (FRCPath), London, which is again a measure of esteem linked to research output.

In the years preceding my move to Australia in July 2003, I held around $450,000 AUD in funding. Since taking up my present position at the UoN, I have received 28 successful grants worth $1,247,181 against a career total of $1,692,701 (as of June 2017).

I have helped lead the establishment of a well equipped PC2 laboratory directed to molecular nutrition that includes real time PCR equipment, dHPLC, LCMS, an imaging platform and other key technologies, and which has recently expanded to include a broad repertoire of tissue culture methodologies. My UoN research/honours students include 10x Honours, 1x Intercalating BMedSci, 1x Masters, 10x PhD, 2xRA and 1x Fellow. Over my career this equates to 10x Honours, 12x PhD, 7x RAs, 7x Intercalating BMedSci students, 1x Masters, 1x Fellow.

Research Expertise

Vitamin Biology with a focus on folic acid and vitamin D. See above for specific research foci.

Teaching Expertise

I am convener for three courses in the Bachelor of Food Science & Human Nutrition Program, all of which I developed and deliver (Micronutrients, Biology of nutrients through the lifecycle, and Functional foods and health claims). In Dec 2005 I was recipient of the Faculty of Science and IT Teaching and Learning Award, and in 2006 I received the Vice Chancellor’s Citation for Outstanding Contributions to Student Learning. I was also a UoN nominee for the National Award of ‘Carrick Citation for Outstanding Contributions to Student Learning’.

Administrative Expertise

I have been Deputy Head of School, SACO, FR&RT & FT&L Committee member and Program Leader.

Collaborations
Many national and International (UK, USA, Canada) collaborators with significant and/or high impact joint research output. The majority of these relate to shared work in my core area of “folic acid chemistry, metabolism and genetics in health and disease”.


Qualifications

  • PhD, University of Leeds - UK
  • Bachelor of Science (Honours), University of Bradford, UK

Keywords

  • Ageing
  • B-Vitamins
  • Birth defects
  • Cancer
  • Developmental Origins
  • Diet in Human Ecology
  • Epigenetics
  • Evolutionary/Darwinian Medicine
  • Folic acid
  • Functional foods and health claims
  • Micronutrients
  • Molecular Nutrition
  • Nutrient bioavailability
  • Nutrition and Human Evolution
  • Nutrition through the lifecycle
  • Nutritional Biochemistry
  • Nutritional Genetics
  • Vascular disease
  • Vitamin B12
  • Vitamin D

Fields of Research

Code Description Percentage
111199 Nutrition and Dietetics not elsewhere classified 30
110399 Clinical Sciences not elsewhere classified 40
060499 Genetics not elsewhere classified 30

Professional Experience

UON Appointment

Title Organisation / Department
Associate Professor University of Newcastle
School of Environmental and Life Sciences
Australia

Academic appointment

Dates Title Organisation / Department
Fellow of the Royal College of Pathologists (FRCPath) Royal College of Pathologists, London
United Kingdom
Fellow of the Royal Society of Biology (FRSB) Royal Society of Biology, London
United Kingdom
1/01/2006 -  Scientific advisor - mandatory fortification of the Australian diet with folic acid FSANZ (Food standards Australia & New Zealand)
Australia

Professional appointment

Dates Title Organisation / Department
Chartered Biologist (CBiol) Royal Society of Biology, London
United Kingdom

Awards

Distinction

Year Award
2006 Vice-Chancellor's Citations for Outstanding Contributions to Student Learning
University of Newcastle

Recognition

Year Award
2005 Faculty of Science & IT Teaching & Learning Award
University of Newcastle

Invitations

Participant

Year Title / Rationale
2007 All invitations relate to folate
Organisation: Several both national and international Description: Invariably based on research expertise and interest in B-vitamins and health
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Grants and Funding

Summary

Number of grants 30
Total funding $1,306,695

Click on a grant title below to expand the full details for that specific grant.


20173 grants / $91,045

Researcher Equipment Grant$49,789

UON 2017 Researcher Equipment Grant

Institution Number: G1701160

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team

Emma Beckett, Chris Scarlett, Jude Weidenhofer, Dean Sculley, Martin Veysey, Zoe Yates, Danielle Bond

Scheme Researcher Equipment Grant
Role Investigator
Funding Start 2017
Funding Finish 2017
GNo
Type Of Funding Internal
Category INTE
UON N

Light Sensitive Vitamins - Relationship with Environmental and Genetic Factors$31,531

Funding body: Central Coast Local Health District

Funding body Central Coast Local Health District
Project Team Associate Professor Mark Lucock, Associate Professor Martin Veysey, Doctor Emma Beckett
Scheme Research Grant
Role Lead
Funding Start 2017
Funding Finish 2020
GNo G1700259
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Taste receptor genetics, the microbiota and metabolic disease risk – a pilot study $9,725

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Emma Beckett, Associate Professor Mark Lucock
Scheme Ourimbah Strategic Pilot Grant
Role Investigator
Funding Start 2017
Funding Finish 2017
GNo G1701265
Type Of Funding Internal
Category INTE
UON Y

20121 grants / $24,500

Phase I and II detoxification genes; the correlation of epigenetic modifications with nutritional status, lifestyle factors, health and disease$24,500

Funding body: CSIRO - Energy Technology

Funding body CSIRO - Energy Technology
Project Team Associate Professor Mark Lucock, Associate Professor Martin Veysey, Doctor Zoe Yates, Miss Emma Beckett, Dr Konsta Duesing
Scheme Postgraduate Research Scholarship
Role Lead
Funding Start 2012
Funding Finish 2015
GNo G1200845
Type Of Funding Other Public Sector - Commonwealth
Category 2OPC
UON Y

20102 grants / $103,420

Vitamin-related nutrigenetic research to support PhD studies$67,056

Consumable budget to support a number of PhD projects on vitamin-related nutrigenetic research

Funding body: Central Coast Health Teaching & Research Unit

Funding body Central Coast Health Teaching & Research Unit
Project Team

Mark Lucock, Martin Veysey

Scheme Postgraduate Research Scholarship
Role Lead
Funding Start 2010
Funding Finish 2017
GNo
Type Of Funding Other Public Sector - State
Category 2OPS
UON N

Is retirement village living good for health: Comparing the health of older adults living in retirement villages and the community$36,364

Funding body: Valhalla Village Pty Ltd

Funding body Valhalla Village Pty Ltd
Project Team Associate Professor Martin Veysey, Dr Peter Lewis, Associate Professor Mark Lucock, Doctor Paul Roach, Dr David Kennedy
Scheme Linkage Projects Partner Funding
Role Investigator
Funding Start 2010
Funding Finish 2011
GNo G1000936
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20091 grants / $61,281

The Association between Folate Nutritional Status and Folate Gene Polymorphisms in an Elderly Australian Population$61,281

Funding body: Central Coast Local Health District

Funding body Central Coast Local Health District
Project Team Associate Professor Martin Veysey, Doctor Zoe Yates, Associate Professor Mark Lucock, Doctor Paul Roach
Scheme Research Sponsorship Scholarship
Role Investigator
Funding Start 2009
Funding Finish 2011
GNo G0190658
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

20084 grants / $685,923

Is retirement village living good for health: Comparing the health of older adults living in retirement villages and the community$390,173

Funding body: ARC (Australian Research Council)

Funding body ARC (Australian Research Council)
Project Team Associate Professor Martin Veysey, Dr Peter Lewis, Associate Professor Mark Lucock, Doctor Paul Roach, Dr David Kennedy
Scheme Linkage Projects
Role Investigator
Funding Start 2008
Funding Finish 2010
GNo G0188386
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Is retirement village living good for health: Comparing the health of older adults living in retirement villages and the community$195,750

Funding body: Central Coast Local Health District

Funding body Central Coast Local Health District
Project Team Associate Professor Martin Veysey, Dr Peter Lewis, Associate Professor Mark Lucock, Doctor Paul Roach, Dr David Kennedy
Scheme Linkage Projects Partner Funding
Role Investigator
Funding Start 2008
Funding Finish 2014
GNo G0188995
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Is retirement village living good for health: Comparing the health of older adults living in retirement villages and the community$85,000

Funding body: UnitingCare Ageing NSW.ACT

Funding body UnitingCare Ageing NSW.ACT
Project Team Associate Professor Martin Veysey, Dr Peter Lewis, Associate Professor Mark Lucock, Doctor Paul Roach, Dr David Kennedy
Scheme Linkage Projects Partner Funding
Role Investigator
Funding Start 2008
Funding Finish 2010
GNo G0189230
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

Is retirement village living good for health: Comparing the health of older adults living in retirement villages and the community$15,000

Funding body: Urbis Pty Ltd

Funding body Urbis Pty Ltd
Project Team Associate Professor Martin Veysey, Dr Peter Lewis, Associate Professor Mark Lucock, Doctor Paul Roach, Dr David Kennedy
Scheme Linkage Projects Partner Funding
Role Investigator
Funding Start 2008
Funding Finish 2010
GNo G0189232
Type Of Funding Aust Competitive - Commonwealth
Category 1CS
UON Y

20073 grants / $55,088

The role of folic acid nutritional genetics in common chronic degenerative disorders$29,424

Funding body: Central Coast Local Health District

Funding body Central Coast Local Health District
Project Team Associate Professor Mark Lucock, Mrs Lyndell Boyd
Scheme Research Sponsorship Scholarship
Role Lead
Funding Start 2007
Funding Finish 2009
GNo G0187843
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

Bitter taste phenotype, dietary pattern and nutritional genetics in the aetiopathology of human colonic adenoma/cancer$15,000

AI on UoN Pilot Grant

Funding body: Faculty of Science and IT, University of Newcastle

Funding body Faculty of Science and IT, University of Newcastle
Project Team

Zoe Yates, Mark Lucock

Scheme UoN Pilot Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo
Type Of Funding Internal
Category INTE
UON N

Maternal probiotic treatment protects against colonic and immune dysfunctions induced by neonatal stress$10,664

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Professor Deborah Hodgson, Doctor Michelle Adams, Associate Professor Mark Lucock
Scheme Pilot Grant
Role Investigator
Funding Start 2007
Funding Finish 2007
GNo G0187857
Type Of Funding Internal
Category INTE
UON Y

20053 grants / $50,044

2005 RIBG allocation$31,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Mark Lucock
Scheme Research Infrastructure Block Grant (RIBG)
Role Lead
Funding Start 2005
Funding Finish 2005
GNo G0185844
Type Of Funding Internal
Category INTE
UON Y

Vitamin B12 and Autism$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Doctor Michelle Adams, Associate Professor Mark Lucock
Scheme Project Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0184636
Type Of Funding Internal
Category INTE
UON Y

Central Coast Vascular Health in Retirement Village Residents Study, Phase 1$9,044

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Martin Veysey, Associate Professor Mark Lucock
Scheme Project Grant
Role Investigator
Funding Start 2005
Funding Finish 2005
GNo G0184680
Type Of Funding Internal
Category INTE
UON Y

20048 grants / $177,316

PhD - Physio-chemical properties and genetic factors that influence folic acid bioavailability and metabolism: Implications in health and disease$66,084

Funding body: Central Coast Health Teaching & Research Unit

Funding body Central Coast Health Teaching & Research Unit
Project Team Associate Professor Mark Lucock, Miss Xiaowei Ng
Scheme Postgraduate Research Scholarship
Role Lead
Funding Start 2004
Funding Finish 2007
GNo G0184604
Type Of Funding Other Public Sector - State
Category 2OPS
UON Y

B-vitamin nutrigenomics in risk for, and progression of, dementia-Pfizer Neuroscience Grant$44,000

Pfizer neuroscience research grant funded a BioRad real time PCR machine

Funding body: Pfizer

Funding body Pfizer
Project Team

Jonathan Sturm, Martin Veysey, Mark Lucock

Scheme Pfizer Neuroscience Research Grant
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo
Type Of Funding Grant - Aust Non Government
Category 3AFG
UON N

Centrifugal Evaporator and Solid Phase Vacuum Manifold System$20,534

Funding body: Faculty of Science and Information Technology, The University of Newcastle | Australia

Funding body Faculty of Science and Information Technology, The University of Newcastle | Australia
Scheme Faculty Large Equipment Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo
Type Of Funding Internal
Category INTE
UON N

Vitamin B12 and gene interactions in autism$20,000

Funding body: Hunter Children`s Research Foundation

Funding body Hunter Children`s Research Foundation
Project Team Doctor Michelle Adams, Associate Professor Mark Lucock, Conjoint Associate Professor John Stuart
Scheme Research Grant
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo G0184142
Type Of Funding Contract - Aust Non Government
Category 3AFC
UON Y

Equipment Funding for a Leica Inverted Microscope$10,000

Funding body: Faculty of Science and Information Technology, University of Newcastle

Funding body Faculty of Science and Information Technology, University of Newcastle
Scheme Small Research Grants
Role Lead
Funding Start 2004
Funding Finish 2004
GNo
Type Of Funding Internal
Category INTE
UON N

Equipment Grant for Bio-Tek Absorbance Microplate Reader$9,164

IGS Funding for a microplate reader

Funding body: Faculty of Science and IT, University of Newcastle

Funding body Faculty of Science and IT, University of Newcastle
Scheme Strategic Small Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo
Type Of Funding Internal
Category INTE
UON N

Salary for Vitamin B12 and Autism Study$5,000

Salary for a Research Assistant

Funding body: Faculty of Science and IT, University of Newcastle

Funding body Faculty of Science and IT, University of Newcastle
Project Team

Dr Michelle Adams, Mark Lucock

Scheme Funded through the School of Applied Sciences
Role Investigator
Funding Start 2004
Funding Finish 2004
GNo
Type Of Funding Internal
Category INTE
UON N

Equipment Grant-RIB for Microfuge$2,534

RIB Grant to purchase a Microfuge

Funding body: University of Newcastle

Funding body University of Newcastle
Scheme RIB Grant
Role Lead
Funding Start 2004
Funding Finish 2004
GNo
Type Of Funding Internal
Category INTE
UON N

20035 grants / $58,078

3 months salary for research assistant$15,000

Salary for visiting research scholar

Funding body: Faculty of Science and Information Technology, University of Newcastle

Funding body Faculty of Science and Information Technology, University of Newcastle
Project Team

Mark Lucock and Zoe Yates

Scheme Small Research Grants
Role Lead
Funding Start 2003
Funding Finish 2004
GNo
Type Of Funding Internal
Category INTE
UON N

School Start up funds for Nutritional Genetics Study$13,078

Funding body: Faculty of Science and Information Technology, University of Newcastle

Funding body Faculty of Science and Information Technology, University of Newcastle
Project Team

Mark Lucock

Scheme Faculty Strategic Small Grant
Role Lead
Funding Start 2003
Funding Finish 2004
GNo
Type Of Funding Internal
Category INTE
UON N

B-vitamin nutrition and genetics in degenerative and development disorders: A study of nutrient-nutrient, nutrient-gene and gene-gene interactions$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Project Team Associate Professor Mark Lucock
Scheme New Staff Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo G0183548
Type Of Funding Internal
Category INTE
UON Y

Effect of Proton Pump Inhibitors and Genetic Variation on B-Vitamin Bioavailability $10,000

Funding body: Central Coast Health

Funding body Central Coast Health
Project Team

Martin Veysey

Scheme Research Grant
Role Investigator
Funding Start 2003
Funding Finish 2003
GNo
Type Of Funding External
Category EXTE
UON N

B-vitamin nutrition and genetics in degenerative and development disorders: A study of nutrient-nutrient, nutrient-gene and gene-gene interactions$10,000

Funding body: University of Newcastle

Funding body University of Newcastle
Scheme New Staff Grant
Role Lead
Funding Start 2003
Funding Finish 2003
GNo
Type Of Funding Internal
Category INTE
UON N
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Research Supervision

Number of supervisions

Completed12
Current5

Total current UON EFTSL

PhD0.85

Current Supervision

Commenced Level of Study Research Title Program Supervisor Type
2017 PhD Light Sensitive Vitamins' Relationship with Environmental and Genetic Factors PhD (Food Science), Faculty of Science, The University of Newcastle Principal Supervisor
2017 PhD Determinants of Sour Taste and Consequences for Dietary Habits PhD (Food Science), Faculty of Science, The University of Newcastle Principal Supervisor
2007 PhD The role of folic acid nutritional genetics in common chronic degenerative disorders Food Science & Biotechnology, University of Newcastle Co-Supervisor
2004 PhD Physico-chemical Properties and Genetic Factors that influence the Bioavailability and Metabolism of Folic Acid: Implications in Health and Disease Food Science & Biotechnology, University of Newcastle Principal Supervisor
2003 PhD Investigation of Anti-inflammatory Properties in Dodonaea Species Food Science & Biotechnology, University of Newcastle Co-Supervisor

Past Supervision

Year Level of Study Research Title Program Supervisor Type
2016 PhD Folate and Vitamin D: The Role of Nutritional Status and Nutrigenetics in Predicting Levels of Extracellular microRNA and Circulating DNA Methylation Status PhD (Food Science), Faculty of Science, The University of Newcastle Principal Supervisor
2016 PhD Genotype-Phenotype Relationships Relevant to the Lifecycle with Special Reference to Vitamin Nutrition PhD (Food Science), Faculty of Science, The University of Newcastle Co-Supervisor
2014 PhD The Role of Folic Acid Related Nutritional Genetics in Common Chronic Degenerative Disorders PhD (Food Science), Faculty of Science, The University of Newcastle Principal Supervisor
2014 PhD In Vitro and In Vivo Approaches to the Examination of Folate-Related Nutritional Genetics in Health and Disease PhD (Food Science), Faculty of Science, The University of Newcastle Co-Supervisor
2009 PhD Physico-Chemical Properties and Genetic Factors That Influence the Bioavailability and Metabolism of Folic Acid: Implications in Health and Diseases PhD (Food Science), Faculty of Science, The University of Newcastle Principal Supervisor
2009 PhD Flavonoid Profile and Bioactivity of Dodonaea Viscosa (Australian Hop Bush) - An Indigenous Shrub PhD (Food Science), Faculty of Science, The University of Newcastle Co-Supervisor
2008 PhD The Effect of Temperature Management on the Quality of Broccoli and Table Grapes Exported from Australia PhD (Food Science), Faculty of Science, The University of Newcastle Co-Supervisor
2007 PhD Optimisation Of Polysaccharides from Echinacea Purpurea PhD (Food Science), Faculty of Science, The University of Newcastle Co-Supervisor
2006 Honours THE EFFECT OF NUTRITION AND GENETIC VARIANTS OF VITAMIN B12 METABOLISM ON BIOCHEMICAL AND CLINICAL PHENOTYPE IN AN ELDERLY POPULATION Food Science & Biotechnology, University of Newcastle Co-Supervisor
2006 Honours The effect of temperature on (-)-epigallochatechin gallate, the major catechin in green tea Food Science & Biotechnology, University of Newcastle Co-Supervisor
2005 Honours Does the G80A reduced folate carrier variant alter the cellular level of folate and as a consequence plasma homocysteine, and is this influenced by folate intake Food Prcessing Technology, University of Newcastle Co-Supervisor
2005 Honours Is cognitive function related to plasma thiol disposition in an elderly population Food Science & Biotechnology, University of Newcastle Co-Supervisor
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News

Health Check

Health check: antioxidants vs free radicals

October 9, 2013

Health Check: the untrue story of antioxidants vs free radicals

Associate Professor Mark Lucock

Position

Associate Professor
Human Molecular Nutrition
School of Environmental and Life Sciences
Faculty of Science

Focus area

Applied Sciences

Contact Details

Email mark.lucock@newcastle.edu.au
Phone (02) 4348 4109
Fax (02) 4348 4145

Office

Room E1.25
Building Science Offices.
Location Ourimbah
10 Chittaway Road
Ourimbah, NSW 2258
Australia
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